locus-tag	class	description
C4N11_RS00010	COG0592	DNA-directed DNA polymerase activity
C4N11_RS00020	COG0012	GTP binding
C4N11_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4N11_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4N11_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4N11_RS00135	COG0582	viral genome integration into host DNA
C4N11_RS00140	COG0582	viral genome integration into host DNA
C4N11_RS00195	COG0756	dUTP diphosphatase activity
C4N11_RS00205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4N11_RS00220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4N11_RS00235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4N11_RS00235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4N11_RS00240	COG1832	CoA-binding protein
C4N11_RS00250	COG2855	membrane
C4N11_RS00255	COG0436	Aminotransferase
C4N11_RS00270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4N11_RS00285	COG2274	protein secretion by the type I secretion system
C4N11_RS00290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4N11_RS00300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4N11_RS00305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4N11_RS00315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4N11_RS00330	COG0151	Belongs to the GarS family
C4N11_RS00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4N11_RS00360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4N11_RS00365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4N11_RS00365	COG3583	domain protein
C4N11_RS00365	COG3064	Membrane
C4N11_RS00380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS00385	COG3715	PTS system
C4N11_RS00390	COG3716	PTS system mannose fructose sorbose family IID component
C4N11_RS00400	COG2222	sugar isomerase
C4N11_RS00410	COG2514	catechol 2,3-dioxygenase activity
C4N11_RS00415	COG1937	Protein conserved in bacteria
C4N11_RS00450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4N11_RS00455	COG0569	domain protein
C4N11_RS00465	COG1215	transferase activity, transferring glycosyl groups
C4N11_RS00485	COG5002	protein histidine kinase activity
C4N11_RS00515	COG4209	transmembrane transport
C4N11_RS00520	COG0395	ABC-type sugar transport system, permease component
C4N11_RS00560	COG1695	Transcriptional regulator
C4N11_RS00590	COG0546	phosphoglycolate phosphatase activity
C4N11_RS00595	COG1760	l-serine dehydratase
C4N11_RS00600	COG1760	l-serine dehydratase
C4N11_RS00630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N11_RS00690	COG0494	nUDIX hydrolase
C4N11_RS00695	COG0445	tRNA wobble uridine modification
C4N11_RS00730	COG1214	PFAM Peptidase M22, glycoprotease
C4N11_RS00805	COG1396	sequence-specific DNA binding
C4N11_RS00835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N11_RS00840	COG1464	Belongs to the NlpA lipoprotein family
C4N11_RS00845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N11_RS00850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4N11_RS00870	COG2972	Histidine kinase
C4N11_RS00875	COG2207	Transcriptional regulator
C4N11_RS00875	COG4753	response regulator
C4N11_RS00885	COG1780	Probably involved in ribonucleotide reductase function
C4N11_RS00925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4N11_RS00925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4N11_RS00945	COG2818	Glycosylase
C4N11_RS00970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4N11_RS00975	COG0006	proline dipeptidase activity
C4N11_RS00985	COG1393	Belongs to the ArsC family
C4N11_RS01010	COG0285	dihydrofolate synthase activity
C4N11_RS01020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4N11_RS01085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4N11_RS01110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4N11_RS01150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4N11_RS01165	COG0201	protein transport
C4N11_RS01175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4N11_RS01180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4N11_RS01190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4N11_RS01195	COG0202	RNA polymerase activity
C4N11_RS01205	COG3830	Belongs to the UPF0237 family
C4N11_RS01235	COG3842	ATPase activity
C4N11_RS01250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4N11_RS01255	COG1349	DNA-binding transcription factor activity
C4N11_RS01265	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4N11_RS01270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N11_RS01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N11_RS01280	COG1882	Formate acetyltransferase
C4N11_RS01325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4N11_RS01330	COG4589	Belongs to the CDS family
C4N11_RS01335	COG0750	zinc metalloprotease
C4N11_RS01345	COG2723	6-phospho-beta-galactosidase activity
C4N11_RS01350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4N11_RS01360	COG1523	belongs to the glycosyl hydrolase 13 family
C4N11_RS01385	COG2176	DNA-directed DNA polymerase activity
C4N11_RS01410	COG2309	aminopeptidase activity
C4N11_RS01415	COG2261	transglycosylase associated protein
C4N11_RS01425	COG1187	pseudouridine synthase activity
C4N11_RS01435	COG3579	cysteine-type endopeptidase activity
C4N11_RS01440	COG3716	PTS system mannose fructose sorbose family IID component
C4N11_RS01445	COG3715	PTS system
C4N11_RS01455	COG1064	alcohol dehydrogenase
C4N11_RS01460	COG0561	phosphatase activity
C4N11_RS01465	COG2252	PERMEase
C4N11_RS01475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4N11_RS01480	COG0285	dihydrofolate synthase activity
C4N11_RS01490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4N11_RS01490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4N11_RS01500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4N11_RS01530	COG0386	Belongs to the glutathione peroxidase family
C4N11_RS01535	COG5492	domain, Protein
C4N11_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
C4N11_RS01575	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C4N11_RS01580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS01585	COG3715	PTS system
C4N11_RS01590	COG3716	PTS system mannose fructose sorbose family IID component
C4N11_RS01605	COG1609	Transcriptional regulator
C4N11_RS01630	COG4839	cell division protein FtsL
C4N11_RS01635	COG0768	penicillin binding
C4N11_RS01665	COG0366	Alpha amylase catalytic
C4N11_RS01670	COG4166	transmembrane transport
C4N11_RS01685	COG4464	protein tyrosine phosphatase activity
C4N11_RS01690	COG3944	biosynthesis protein
C4N11_RS01695	COG0489	protein tyrosine kinase activity
C4N11_RS01715	COG1216	Glycosyl transferase, family 2
C4N11_RS01715	COG1442	glycosyl transferase family 8
C4N11_RS01735	COG0371	Dehydrogenase
C4N11_RS01740	COG1213	nucleotidyl transferase
C4N11_RS01745	COG0647	UMP catabolic process
C4N11_RS01750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4N11_RS01760	COG1088	dTDP-glucose 4,6-dehydratase activity
C4N11_RS01765	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4N11_RS01785	COG4166	transmembrane transport
C4N11_RS01795	COG0366	Alpha amylase catalytic
C4N11_RS01800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4N11_RS01825	COG0116	Belongs to the methyltransferase superfamily
C4N11_RS01835	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4N11_RS01840	COG0745	RESPONSE REGULATOR receiver
C4N11_RS01900	COG4585	Histidine kinase
C4N11_RS01905	COG2197	response regulator
C4N11_RS01945	COG2213	PTS system mannitol-specific
C4N11_RS01950	COG3711	transcriptional antiterminator
C4N11_RS01955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N11_RS01975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4N11_RS01980	COG0681	Belongs to the peptidase S26 family
C4N11_RS02005	COG1115	amino acid carrier protein
C4N11_RS02030	COG0527	aspartate kinase activity
C4N11_RS02040	COG1024	Enoyl-CoA hydratase
C4N11_RS02045	COG1846	Transcriptional regulator
C4N11_RS02055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4N11_RS02065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4N11_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
C4N11_RS02075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4N11_RS02090	COG0439	Biotin carboxylase
C4N11_RS02095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4N11_RS02155	COG1442	glycosyl transferase family 8
C4N11_RS02160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4N11_RS02170	COG1461	Dihydroxyacetone kinase
C4N11_RS02175	COG0028	Belongs to the TPP enzyme family
C4N11_RS02180	COG0440	acetolactate synthase activity
C4N11_RS02200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4N11_RS02220	COG0765	amino acid transport
C4N11_RS02240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4N11_RS02250	COG1882	Formate acetyltransferase
C4N11_RS02280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4N11_RS02285	COG0569	domain protein
C4N11_RS02300	COG1122	ATPase activity
C4N11_RS02315	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C4N11_RS02320	COG0671	phosphoesterase, PA-phosphatase related
C4N11_RS02330	COG1247	-acetyltransferase
C4N11_RS02340	COG0504	CTP synthase activity
C4N11_RS02345	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4N11_RS02365	COG0789	Transcriptional regulator
C4N11_RS02370	COG0174	glutamine synthetase
C4N11_RS02390	COG0732	type I restriction modification DNA specificity domain
C4N11_RS02400	COG4974	Belongs to the 'phage' integrase family
C4N11_RS02450	COG0484	heat shock protein binding
C4N11_RS02470	COG0537	adenosine 5'-monophosphoramidase activity
C4N11_RS02475	COG1131	(ABC) transporter
C4N11_RS02505	COG3290	protein histidine kinase activity
C4N11_RS02515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4N11_RS02520	COG2274	protein secretion by the type I secretion system
C4N11_RS02595	COG1266	CAAX protease self-immunity
C4N11_RS02615	COG0195	Participates in both transcription termination and antitermination
C4N11_RS02620	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C4N11_RS02685	COG0519	Catalyzes the synthesis of GMP from XMP
C4N11_RS02695	COG0525	valine-tRNA ligase activity
C4N11_RS02720	COG3711	transcriptional antiterminator
C4N11_RS02725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS02725	COG1263	PTS System
C4N11_RS02725	COG2190	(PTS) system
C4N11_RS02740	COG0456	acetyltransferase
C4N11_RS02745	COG0072	phenylalanine-tRNA ligase activity
C4N11_RS02745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N11_RS02760	COG3620	sequence-specific DNA binding
C4N11_RS02765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4N11_RS02785	COG1045	serine acetyltransferase
C4N11_RS02800	COG0215	cysteine-tRNA ligase activity
C4N11_RS02805	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C4N11_RS02830	COG0577	efflux transmembrane transporter activity
C4N11_RS02835	COG1136	(ABC) transporter
C4N11_RS02840	COG0577	efflux transmembrane transporter activity
C4N11_RS02845	COG0745	RESPONSE REGULATOR receiver
C4N11_RS02850	COG5002	protein histidine kinase activity
C4N11_RS02855	COG0191	fructose-bisphosphate aldolase activity
C4N11_RS02860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4N11_RS02865	COG0765	amino acid transport
C4N11_RS02870	COG0765	amino acid transport
C4N11_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N11_RS02885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4N11_RS02885	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4N11_RS02925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N11_RS02940	COG1573	uracil-dna glycosylase
C4N11_RS02955	COG1114	Component of the transport system for branched-chain amino acids
C4N11_RS02960	COG1363	Peptidase, m42
C4N11_RS02995	COG4555	ABC transporter
C4N11_RS03030	COG1404	Belongs to the peptidase S8 family
C4N11_RS03045	COG3775	system Galactitol-specific IIC component
C4N11_RS03050	COG3250	beta-galactosidase activity
C4N11_RS03070	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C4N11_RS03090	COG0785	Cytochrome C biogenesis protein
C4N11_RS03095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4N11_RS03100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N11_RS03100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N11_RS03105	COG2207	Transcriptional regulator
C4N11_RS03105	COG4753	response regulator
C4N11_RS03110	COG2972	Histidine kinase
C4N11_RS03120	COG3064	Membrane
C4N11_RS03125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4N11_RS03140	COG1940	carbohydrate kinase activity
C4N11_RS03160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4N11_RS03165	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C4N11_RS03175	COG0300	oxidoreductase activity
C4N11_RS03190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4N11_RS03200	COG1187	pseudouridine synthase activity
C4N11_RS03225	COG1136	(ABC) transporter
C4N11_RS03240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4N11_RS03250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4N11_RS03275	COG1131	(ABC) transporter
C4N11_RS03285	COG1126	abc transporter atp-binding protein
C4N11_RS03290	COG0765	amino acid transport
C4N11_RS03300	COG1304	FMN binding
C4N11_RS03310	COG1304	FMN binding
C4N11_RS03335	COG0352	thiamine-phosphate diphosphorylase activity
C4N11_RS03350	COG4172	Belongs to the ABC transporter superfamily
C4N11_RS03360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C4N11_RS03375	COG0352	thiamine-phosphate diphosphorylase activity
C4N11_RS03395	COG2217	Heavy metal translocating P-type atpase
C4N11_RS03400	COG0028	Belongs to the TPP enzyme family
C4N11_RS03415	COG2723	6-phospho-beta-galactosidase activity
C4N11_RS03420	COG1482	cell wall glycoprotein biosynthetic process
C4N11_RS03445	COG2081	HI0933 family
C4N11_RS03450	COG1307	EDD domain protein, DegV family
C4N11_RS03460	COG2131	deaminase
C4N11_RS03465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4N11_RS03510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4N11_RS03510	COG0617	tRNA 3'-terminal CCA addition
C4N11_RS03510	COG0517	IMP dehydrogenase activity
C4N11_RS03520	COG2884	Cell division ATP-binding protein ftsE
C4N11_RS03525	COG2177	Part of the ABC transporter FtsEX involved in
C4N11_RS03530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS03530	COG2190	(PTS) system
C4N11_RS03530	COG1263	PTS System
C4N11_RS03540	COG0513	Belongs to the DEAD box helicase family
C4N11_RS03555	COG0167	dihydroorotate dehydrogenase activity
C4N11_RS03565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4N11_RS03570	COG4470	Protein conserved in bacteria
C4N11_RS03575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4N11_RS03585	COG0488	(ABC) transporter
C4N11_RS03620	COG1837	Belongs to the UPF0109 family
C4N11_RS03645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4N11_RS03645	COG1328	CTP reductase activity
C4N11_RS03655	COG4443	Transcriptional Coactivator p15 (PC4)
C4N11_RS03665	COG1268	BioY protein
C4N11_RS03680	COG1136	(ABC) transporter
C4N11_RS03680	COG0577	efflux transmembrane transporter activity
C4N11_RS03690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4N11_RS03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4N11_RS03700	COG1136	(ABC) transporter
C4N11_RS03705	COG0577	efflux transmembrane transporter activity
C4N11_RS03710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N11_RS03710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N11_RS03730	COG4989	oxidoreductase activity
C4N11_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
C4N11_RS03775	COG0745	RESPONSE REGULATOR receiver
C4N11_RS03780	COG5002	protein histidine kinase activity
C4N11_RS03800	COG0772	Belongs to the SEDS family
C4N11_RS03805	COG0693	protein deglycase activity
C4N11_RS03815	COG0187	DNA topoisomerase II activity
C4N11_RS03860	COG0542	response to heat
C4N11_RS03865	COG4703	Protein of unknown function (DUF1797)
C4N11_RS03870	COG0765	amino acid transport
C4N11_RS03875	COG1126	abc transporter atp-binding protein
C4N11_RS03880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4N11_RS03890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4N11_RS03910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4N11_RS03965	COG2813	Specifically methylates the guanine in position
C4N11_RS03970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C4N11_RS03980	COG0295	cytidine deaminase activity
C4N11_RS03985	COG1744	ABC transporter substrate-binding protein PnrA-like
C4N11_RS04015	COG0187	DNA topoisomerase II activity
C4N11_RS04020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4N11_RS04025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4N11_RS04030	COG4166	transmembrane transport
C4N11_RS04065	COG0539	negative regulation of cytoplasmic translation
C4N11_RS04075	COG1956	GAF domain-containing protein
C4N11_RS04080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4N11_RS04095	COG0719	Fe-S assembly protein
C4N11_RS04100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4N11_RS04110	COG0719	Fe-S assembly protein
C4N11_RS04115	COG1686	Belongs to the peptidase S11 family
C4N11_RS04120	COG0628	permease
C4N11_RS04135	COG1349	DNA-binding transcription factor activity
C4N11_RS04140	COG1105	Belongs to the carbohydrate kinase PfkB family
C4N11_RS04145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N11_RS04145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4N11_RS04145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N11_RS04150	COG1674	ftsk spoiiie
C4N11_RS04150	COG0697	spore germination
C4N11_RS04165	COG1104	cysteine desulfurase activity
C4N11_RS04220	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C4N11_RS04225	COG1438	arginine binding
C4N11_RS04245	COG0469	pyruvate kinase activity
C4N11_RS04295	COG3689	TIGRFAM TIGR03943 family protein
C4N11_RS04300	COG0701	Predicted permease
C4N11_RS04315	COG2183	response to ionizing radiation
C4N11_RS04335	COG1136	(ABC) transporter
C4N11_RS04340	COG0577	efflux transmembrane transporter activity
C4N11_RS04360	COG1982	Orn Lys Arg decarboxylase major
C4N11_RS04370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4N11_RS04395	COG0561	phosphatase activity
C4N11_RS04415	COG0583	DNA-binding transcription factor activity
C4N11_RS04420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4N11_RS04425	COG0564	pseudouridine synthase activity
C4N11_RS04430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C4N11_RS04445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4N11_RS04455	COG0470	DNA polymerase III
C4N11_RS04500	COG0528	UMP kinase activity
C4N11_RS04510	COG2996	Protein conserved in bacteria
C4N11_RS04520	COG1702	phosphate starvation-inducible protein PhoH
C4N11_RS04540	COG0686	Belongs to the AlaDH PNT family
C4N11_RS04545	COG0686	Belongs to the AlaDH PNT family
C4N11_RS04550	COG0686	Belongs to the AlaDH PNT family
C4N11_RS04555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4N11_RS04560	COG1596	polysaccharide export
C4N11_RS04560	COG1555	photosystem II stabilization
C4N11_RS04565	COG0658	competence protein
C4N11_RS04565	COG2333	competence protein COMEC
C4N11_RS04575	COG1131	(ABC) transporter
C4N11_RS04605	COG0543	2 iron, 2 sulfur cluster binding
C4N11_RS04610	COG0167	dihydroorotate dehydrogenase activity
C4N11_RS04615	COG5263	repeat protein
C4N11_RS04615	COG4193	domain, Protein
C4N11_RS04620	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C4N11_RS04630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4N11_RS04640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4N11_RS04645	COG0237	dephospho-CoA kinase activity
C4N11_RS04650	COG2814	Major facilitator Superfamily
C4N11_RS04665	COG0557	exoribonuclease II activity
C4N11_RS04675	COG3615	Tellurite resistance protein tehB
C4N11_RS04675	COG0500	methyltransferase
C4N11_RS04690	COG4122	O-methyltransferase activity
C4N11_RS04720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4N11_RS04735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4N11_RS04740	COG0494	nUDIX hydrolase
C4N11_RS04750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4N11_RS04760	COG2176	DNA-directed DNA polymerase activity
C4N11_RS04765	COG0584	glycerophosphoryl diester phosphodiesterase
C4N11_RS04785	COG0785	Cytochrome C biogenesis protein
C4N11_RS04790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4N11_RS04795	COG0531	amino acid
C4N11_RS04800	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4N11_RS04800	COG3443	Belongs to the bacterial solute-binding protein 9 family
C4N11_RS04845	COG1970	mechanosensitive ion channel activity
C4N11_RS04855	COG4708	membrane
C4N11_RS04870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4N11_RS04880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4N11_RS04885	COG1942	4-Oxalocrotonate Tautomerase
C4N11_RS04890	COG1435	thymidine kinase activity
C4N11_RS04900	COG2890	protein-(glutamine-N5) methyltransferase activity
C4N11_RS04925	COG0741	lytic transglycosylase activity
C4N11_RS04935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4N11_RS04960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N11_RS04965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N11_RS05015	COG1597	lipid kinase activity
C4N11_RS05020	COG0366	Alpha amylase catalytic
C4N11_RS05035	COG1396	sequence-specific DNA binding
C4N11_RS05040	COG0542	response to heat
C4N11_RS05065	COG3843	relaxase mobilization nuclease domain protein
C4N11_RS05100	COG1131	(ABC) transporter
C4N11_RS05130	COG0772	Belongs to the SEDS family
C4N11_RS05135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4N11_RS05150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4N11_RS05155	COG0358	DNA primase activity
C4N11_RS05160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4N11_RS05165	COG2151	metal-sulfur cluster biosynthetic enzyme
C4N11_RS05170	COG0438	transferase activity, transferring glycosyl groups
C4N11_RS05175	COG0438	transferase activity, transferring glycosyl groups
C4N11_RS05200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4N11_RS05210	COG4109	DRTGG domain
C4N11_RS05215	COG0024	Methionine aminopeptidase
C4N11_RS05230	COG0210	DNA helicase
C4N11_RS05240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4N11_RS05260	COG1104	cysteine desulfurase activity
C4N11_RS05265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4N11_RS05275	COG2357	RelA SpoT domain protein
C4N11_RS05285	COG0564	pseudouridine synthase activity
C4N11_RS05290	COG0280	phosphate acetyltransferase
C4N11_RS05330	COG0196	riboflavin kinase activity
C4N11_RS05335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4N11_RS05340	COG1307	EDD domain protein, DegV family
C4N11_RS05350	COG0488	(ABC) transporter
C4N11_RS05360	COG2814	Major facilitator Superfamily
C4N11_RS05370	COG1523	belongs to the glycosyl hydrolase 13 family
C4N11_RS05375	COG1012	belongs to the aldehyde dehydrogenase family
C4N11_RS05385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4N11_RS05395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4N11_RS05425	COG0582	viral genome integration into host DNA
C4N11_RS05465	COG3583	domain protein
C4N11_RS05465	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C4N11_RS05470	COG3064	Membrane
C4N11_RS05475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4N11_RS05495	COG0095	Lipoate-protein ligase
C4N11_RS05500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4N11_RS05505	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4N11_RS05510	COG0022	dehydrogenase e1 component
C4N11_RS05515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4N11_RS05520	COG0534	Mate efflux family protein
C4N11_RS05530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4N11_RS05535	COG1051	belongs to the nudix hydrolase family
C4N11_RS05550	COG1011	Hydrolase
C4N11_RS05555	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C4N11_RS05570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N11_RS05575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4N11_RS05580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4N11_RS05585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4N11_RS05620	COG3711	transcriptional antiterminator
C4N11_RS05625	COG3684	Belongs to the aldolase LacD family
C4N11_RS05670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4N11_RS05675	COG0497	DNA recombination
C4N11_RS05680	COG1438	arginine binding
C4N11_RS05685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4N11_RS05720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4N11_RS05740	COG3764	Sortase (surface protein transpeptidase)
C4N11_RS05745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4N11_RS05755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4N11_RS05770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4N11_RS05775	COG5002	protein histidine kinase activity
C4N11_RS05780	COG0745	RESPONSE REGULATOR receiver
C4N11_RS05785	COG1194	a g-specific adenine glycosylase
C4N11_RS05800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4N11_RS05805	COG4684	Psort location CytoplasmicMembrane, score
C4N11_RS05815	COG1827	regulation of RNA biosynthetic process
C4N11_RS05845	COG0765	amino acid transport
C4N11_RS05850	COG1126	abc transporter atp-binding protein
C4N11_RS05855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4N11_RS05860	COG0552	protein localization to endoplasmic reticulum
C4N11_RS05865	COG0561	phosphatase activity
C4N11_RS05870	COG0561	phosphatase activity
C4N11_RS05875	COG1196	nuclear chromosome segregation
C4N11_RS05900	COG1401	restriction endodeoxyribonuclease activity
C4N11_RS05915	COG0066	3-isopropylmalate dehydratase activity
C4N11_RS05925	COG0473	3-isopropylmalate dehydrogenase activity
C4N11_RS05940	COG3142	Participates in the control of copper homeostasis
C4N11_RS05945	COG2832	Protein of unknown function (DUF454)
C4N11_RS05950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4N11_RS05960	COG0758	DNA mediated transformation
C4N11_RS05965	COG4750	Nucleotidyl transferase
C4N11_RS05980	COG1063	alcohol dehydrogenase
C4N11_RS05995	COG3475	LICD family
C4N11_RS06000	COG3475	LICD family
C4N11_RS06010	COG0505	Belongs to the CarA family
C4N11_RS06025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4N11_RS06045	COG0488	(ABC) transporter
C4N11_RS06055	COG1704	LemA family
C4N11_RS06070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4N11_RS06085	COG1078	dGTPase activity
C4N11_RS06105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4N11_RS06110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4N11_RS06115	COG0077	Prephenate dehydratase
C4N11_RS06115	COG1605	Chorismate mutase
C4N11_RS06120	COG0716	FMN binding
C4N11_RS06125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4N11_RS06145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4N11_RS06240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4N11_RS06245	COG1269	ATP hydrolysis coupled proton transport
C4N11_RS06260	COG0673	inositol 2-dehydrogenase activity
C4N11_RS06265	COG4409	exo-alpha-(2->6)-sialidase activity
C4N11_RS06275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4N11_RS06280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N11_RS06285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4N11_RS06295	COG1737	Transcriptional regulator
C4N11_RS06320	COG1136	(ABC) transporter
C4N11_RS06320	COG0577	efflux transmembrane transporter activity
C4N11_RS06330	COG1770	oligopeptidase
C4N11_RS06335	COG0515	serine threonine protein kinase
C4N11_RS06370	COG4974	Belongs to the 'phage' integrase family
C4N11_RS06385	COG3843	relaxase mobilization nuclease domain protein
C4N11_RS06405	COG0210	DNA helicase
C4N11_RS06440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4N11_RS06490	COG0542	response to heat
C4N11_RS06495	COG1396	sequence-specific DNA binding
C4N11_RS06665	COG1674	ftsk spoiiie
C4N11_RS06675	COG2946	Replication initiation factor
C4N11_RS06705	COG0741	lytic transglycosylase activity
C4N11_RS06705	COG0791	NLP P60 protein
C4N11_RS06785	COG0270	DNA (cytosine-5-)-methyltransferase activity
C4N11_RS06815	COG0402	S-adenosylhomocysteine deaminase activity
C4N11_RS06825	COG1132	(ABC) transporter
C4N11_RS06830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N11_RS06830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4N11_RS06860	COG1215	transferase activity, transferring glycosyl groups
C4N11_RS06870	COG3475	LICD family
C4N11_RS06880	COG0077	Prephenate dehydratase
C4N11_RS06885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4N11_RS06900	COG0287	Prephenate dehydrogenase
C4N11_RS06925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4N11_RS06940	COG1131	(ABC) transporter
C4N11_RS06980	COG3842	ATPase activity
C4N11_RS06995	COG3527	Alpha-acetolactate decarboxylase
C4N11_RS07000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4N11_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N11_RS07010	COG0704	Plays a role in the regulation of phosphate uptake
C4N11_RS07015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4N11_RS07020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4N11_RS07025	COG0581	inorganic phosphate transmembrane transporter activity
C4N11_RS07035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4N11_RS07040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4N11_RS07040	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C4N11_RS07045	COG0483	inositol monophosphate 1-phosphatase activity
C4N11_RS07055	COG1393	Belongs to the ArsC family
C4N11_RS07065	COG0647	UMP catabolic process
C4N11_RS07075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4N11_RS07125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4N11_RS07135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4N11_RS07205	COG1132	(ABC) transporter
C4N11_RS07220	COG1129	ABC transporter
C4N11_RS07265	COG2188	Transcriptional regulator
C4N11_RS07270	COG0697	spore germination
C4N11_RS07275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4N11_RS07290	COG0561	phosphatase activity
C4N11_RS07325	COG0492	ferredoxin-NADP+ reductase activity
C4N11_RS07335	COG1126	abc transporter atp-binding protein
C4N11_RS07345	COG1393	Belongs to the ArsC family
C4N11_RS07365	COG1272	protein, Hemolysin III
C4N11_RS07395	COG1053	succinate dehydrogenase
C4N11_RS07395	COG3976	FMN-binding domain protein
C4N11_RS07395	COG0431	NADPH-dependent FMN reductase
C4N11_RS07425	COG0656	L-ascorbic acid biosynthetic process
C4N11_RS07430	COG0726	polysaccharide deacetylase
C4N11_RS07475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N11_RS07515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4N11_RS07525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4N11_RS07530	COG1126	abc transporter atp-binding protein
C4N11_RS07540	COG0457	Tetratricopeptide repeat
C4N11_RS07545	COG0628	permease
C4N11_RS07550	COG2706	6-phosphogluconolactonase activity
C4N11_RS07610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4N11_RS07635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4N11_RS07640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4N11_RS07645	COG0626	cystathionine gamma-synthase activity
C4N11_RS07650	COG1132	(ABC) transporter
C4N11_RS07655	COG4166	transmembrane transport
C4N11_RS07660	COG2244	polysaccharide biosynthetic process
C4N11_RS07665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4N11_RS07690	COG2827	Endonuclease containing a URI domain
C4N11_RS07695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4N11_RS07700	COG1098	S1 RNA binding domain
C4N11_RS07710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4N11_RS07715	COG0629	single-stranded DNA binding
C4N11_RS07725	COG0017	Asparaginyl-tRNA synthetase
C4N11_RS07730	COG0436	Aminotransferase
C4N11_RS07755	COG3711	transcriptional antiterminator
C4N11_RS07775	COG0242	peptide deformylase activity
C4N11_RS07780	COG0625	glutathione transferase activity
C4N11_RS07790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4N11_RS07795	COG0488	(ABC) transporter
C4N11_RS07800	COG0617	tRNA 3'-terminal CCA addition
C4N11_RS07810	COG1307	EDD domain protein, DegV family
C4N11_RS07830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C4N11_RS07840	COG0492	ferredoxin-NADP+ reductase activity
C4N11_RS07850	COG5263	repeat protein
C4N11_RS07850	COG5632	N-Acetylmuramoyl-L-alanine amidase
C4N11_RS08030	COG0270	DNA (cytosine-5-)-methyltransferase activity
C4N11_RS08035	COG0629	single-stranded DNA binding
C4N11_RS08090	COG0582	viral genome integration into host DNA
C4N11_RS08100	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4N11_RS08110	COG0251	oxidation-reduction process
C4N11_RS08130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4N11_RS08140	COG4193	domain, Protein
C4N11_RS08140	COG5263	repeat protein
C4N11_RS08150	COG3935	DnaD domain protein
C4N11_RS08165	COG2226	methyltransferase
C4N11_RS08170	COG3842	ATPase activity
C4N11_RS08180	COG1335	isochorismatase
C4N11_RS08195	COG0513	Belongs to the DEAD box helicase family
C4N11_RS08200	COG2223	nitrite transmembrane transporter activity
C4N11_RS08205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4N11_RS08210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4N11_RS08215	COG3442	glutamine amidotransferase
C4N11_RS08220	COG0006	proline dipeptidase activity
C4N11_RS08235	COG4720	Psort location CytoplasmicMembrane, score
C4N11_RS08240	COG0351	phosphomethylpyrimidine kinase
C4N11_RS08265	COG2824	Alkylphosphonate utilization operon protein PhnA
C4N11_RS08285	COG0463	Glycosyl transferase, family 2
C4N11_RS08290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4N11_RS08295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4N11_RS08300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4N11_RS08305	COG2384	SAM-dependent methyltransferase
C4N11_RS08310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4N11_RS08315	COG0204	Acyl-transferase
C4N11_RS08330	COG2910	NAD(P)H-binding
C4N11_RS08360	COG5002	protein histidine kinase activity
C4N11_RS08365	COG0745	RESPONSE REGULATOR receiver
C4N11_RS08380	COG1959	2 iron, 2 sulfur cluster binding
C4N11_RS08435	COG3590	peptidase
C4N11_RS08450	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4N11_RS08455	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C4N11_RS08465	COG1136	(ABC) transporter
C4N11_RS08465	COG0577	efflux transmembrane transporter activity
C4N11_RS08505	COG3599	regulation of cell shape
C4N11_RS08525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4N11_RS08545	COG1051	belongs to the nudix hydrolase family
C4N11_RS08550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4N11_RS08565	COG0768	penicillin binding
C4N11_RS08580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4N11_RS08600	COG2731	YhcH YjgK YiaL family protein
C4N11_RS08605	COG0395	ABC-type sugar transport system, permease component
C4N11_RS08610	COG1175	transmembrane transport
C4N11_RS08620	COG1263	PTS System
C4N11_RS08620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS08620	COG2190	(PTS) system
C4N11_RS08630	COG0673	inositol 2-dehydrogenase activity
C4N11_RS08635	COG4409	exo-alpha-(2->6)-sialidase activity
C4N11_RS08645	COG1175	transmembrane transport
C4N11_RS08650	COG1653	transport
C4N11_RS08670	COG3458	cephalosporin-C deacetylase activity
C4N11_RS08680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4N11_RS08695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4N11_RS08700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4N11_RS08705	COG0653	protein targeting
C4N11_RS08715	COG1131	(ABC) transporter
C4N11_RS08755	COG0778	Nitroreductase
C4N11_RS08760	COG1484	DNA-dependent DNA replication
C4N11_RS08775	COG1725	Transcriptional regulator
C4N11_RS08780	COG1131	(ABC) transporter
C4N11_RS08790	COG1668	transmembrane transport
C4N11_RS08795	COG4152	abc transporter atp-binding protein
C4N11_RS08815	COG1940	carbohydrate kinase activity
C4N11_RS08820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS08820	COG2190	(PTS) system
C4N11_RS08820	COG1263	PTS System
C4N11_RS08835	COG1621	beta-fructofuranosidase activity
C4N11_RS08840	COG1609	Transcriptional regulator
C4N11_RS08850	COG3425	synthase
C4N11_RS08875	COG0515	serine threonine protein kinase
C4N11_RS08875	COG2815	serine threonine protein kinase
C4N11_RS08880	COG0631	protein serine/threonine phosphatase activity
C4N11_RS08885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4N11_RS08885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4N11_RS08895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4N11_RS08905	COG0194	GDP metabolic process
C4N11_RS08945	COG2226	methyltransferase
C4N11_RS08950	COG0799	negative regulation of ribosome biogenesis
C4N11_RS08960	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4N11_RS08965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4N11_RS08970	COG1534	Rna-binding protein
C4N11_RS08975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C4N11_RS08990	COG0668	transmembrane transport
C4N11_RS09005	COG4129	membrane
C4N11_RS09025	COG0438	transferase activity, transferring glycosyl groups
C4N11_RS09030	COG0438	transferase activity, transferring glycosyl groups
C4N11_RS09035	COG0653	protein targeting
C4N11_RS09055	COG0201	protein transport
C4N11_RS09060	COG1215	transferase activity, transferring glycosyl groups
C4N11_RS09065	COG1442	glycosyl transferase family 8
C4N11_RS09070	COG1442	glycosyl transferase family 8
C4N11_RS09075	COG1442	glycosyl transferase family 8
C4N11_RS09075	COG1216	Glycosyl transferase, family 2
C4N11_RS09080	COG1442	glycosyl transferase family 8
C4N11_RS09095	COG1442	glycosyl transferase family 8
C4N11_RS09095	COG1216	Glycosyl transferase, family 2
C4N11_RS09100	COG1442	glycosyl transferase family 8
C4N11_RS09105	COG1442	glycosyl transferase family 8
C4N11_RS09105	COG1216	Glycosyl transferase, family 2
C4N11_RS09135	COG3118	belongs to the thioredoxin family
C4N11_RS09140	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4N11_RS09155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N11_RS09165	COG1164	Oligoendopeptidase f
C4N11_RS09170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4N11_RS09240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4N11_RS09250	COG1621	beta-fructofuranosidase activity
C4N11_RS09255	COG1653	transport
C4N11_RS09260	COG0395	ABC-type sugar transport system, permease component
C4N11_RS09265	COG4209	transmembrane transport
C4N11_RS09275	COG3711	transcriptional antiterminator
C4N11_RS09280	COG2261	transglycosylase associated protein
C4N11_RS09300	COG3237	CsbD-like
C4N11_RS09315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4N11_RS09325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N11_RS09330	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4N11_RS09335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N11_RS09345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N11_RS09350	COG1940	carbohydrate kinase activity
C4N11_RS09350	COG1846	Transcriptional regulator
C4N11_RS09405	COG0512	Glutamine amidotransferase of anthranilate synthase
C4N11_RS09410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4N11_RS09425	COG1285	pathogenesis
C4N11_RS09430	COG1178	ABC-type Fe3 transport system permease component
C4N11_RS09450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4N11_RS09455	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C4N11_RS09460	COG0704	Plays a role in the regulation of phosphate uptake
C4N11_RS09475	COG5434	Belongs to the glycosyl hydrolase 28 family
C4N11_RS09485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4N11_RS09490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4N11_RS09500	COG1132	(ABC) transporter
C4N11_RS09505	COG1132	(ABC) transporter
C4N11_RS09525	COG0708	Exodeoxyribonuclease III
C4N11_RS09545	COG2233	PERMEase
C4N11_RS09570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4N11_RS09575	COG1609	Transcriptional regulator
C4N11_RS09580	COG1063	alcohol dehydrogenase
C4N11_RS09585	COG0789	Transcriptional regulator
C4N11_RS09590	COG1230	cation diffusion facilitator family transporter
C4N11_RS09600	COG3201	nicotinamide mononucleotide transporter
C4N11_RS09605	COG1174	glycine betaine transport
C4N11_RS09630	COG1363	Peptidase, m42
C4N11_RS09650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4N11_RS09655	COG4605	iron ion homeostasis
C4N11_RS09660	COG4604	ABC transporter, ATP-binding protein
C4N11_RS09665	COG4607	ABC-type enterochelin transport system periplasmic component
C4N11_RS09675	COG1187	pseudouridine synthase activity
C4N11_RS09695	COG0517	IMP dehydrogenase activity
C4N11_RS09705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4N11_RS09720	COG0366	Alpha amylase catalytic
C4N11_RS09730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS09730	COG1263	PTS System
C4N11_RS09735	COG2188	Transcriptional regulator
C4N11_RS09740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4N11_RS09755	COG4608	Belongs to the ABC transporter superfamily
C4N11_RS09760	COG0444	Belongs to the ABC transporter superfamily
C4N11_RS09765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4N11_RS09770	COG0601	transmembrane transport
C4N11_RS09775	COG0601	transmembrane transport
C4N11_RS09780	COG4166	transmembrane transport
C4N11_RS09795	COG0366	Alpha amylase catalytic
C4N11_RS09800	COG0395	ABC-type sugar transport system, permease component
C4N11_RS09805	COG1175	transmembrane transport
C4N11_RS09810	COG1653	transport
C4N11_RS09815	COG3345	alpha-galactosidase
C4N11_RS09820	COG2207	Transcriptional regulator
C4N11_RS09825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4N11_RS09825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4N11_RS09945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4N11_RS09990	COG4221	oxidoreductase activity
C4N11_RS09995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4N11_RS10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4N11_RS10130	COG5263	repeat protein
C4N11_RS10130	COG5632	N-Acetylmuramoyl-L-alanine amidase
C4N11_RS10155	COG1316	TRANSCRIPTIONal
C4N11_RS10165	COG0802	atpase or kinase
C4N11_RS10230	COG0577	efflux transmembrane transporter activity
C4N11_RS10230	COG1136	(ABC) transporter
C4N11_RS10260	COG1253	flavin adenine dinucleotide binding
C4N11_RS10275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4N11_RS10285	COG3480	Lon protease (S16) C-terminal proteolytic domain
C4N11_RS10295	COG0742	ribosomal rna small subunit methyltransferase
C4N11_RS10315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4N11_RS10320	COG1254	Belongs to the acylphosphatase family
C4N11_RS10330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4N11_RS10340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4N11_RS10360	COG1564	THIamine pyrophosphokinase
C4N11_RS10370	COG1162	GTPase activity
C4N11_RS10405	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4N11_RS10410	COG0084	hydrolase, TatD family'
C4N11_RS10430	COG0436	Aminotransferase
C4N11_RS10440	COG0589	response to stress
C4N11_RS10445	COG0561	phosphatase activity
C4N11_RS10450	COG0252	asparaginase activity
C4N11_RS10455	COG1609	Transcriptional regulator
C4N11_RS10460	COG2197	response regulator
C4N11_RS10465	COG4585	Histidine kinase
C4N11_RS10470	COG0842	Transport permease protein
C4N11_RS10475	COG1131	(ABC) transporter
C4N11_RS10575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4N11_RS10580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4N11_RS10585	COG0564	pseudouridine synthase activity
C4N11_RS10595	COG0577	efflux transmembrane transporter activity
C4N11_RS10605	COG0157	Belongs to the NadC ModD family
C4N11_RS10625	COG1129	ABC transporter
C4N11_RS10630	COG2188	Transcriptional regulator
C4N11_RS10635	COG2723	6-phospho-beta-galactosidase activity
C4N11_RS10640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4N11_RS10650	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4N11_RS10655	COG1454	alcohol dehydrogenase
C4N11_RS10655	COG1012	belongs to the aldehyde dehydrogenase family
C4N11_RS10665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4N11_RS10675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4N11_RS10705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N11_RS10715	COG3037	sugar-specific permease SgaT UlaA
C4N11_RS10725	COG1847	R3H domain protein
C4N11_RS10730	COG0706	membrane insertase activity
C4N11_RS10775	COG4537	Required for transformation and DNA binding
C4N11_RS10780	COG1459	type II secretion system
C4N11_RS10785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4N11_RS10795	COG1063	alcohol dehydrogenase
C4N11_RS10820	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C4N11_RS10825	COG3759	membrane
C4N11_RS10840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4N11_RS10840	COG0131	Imidazoleglycerol-phosphate dehydratase
C4N11_RS10845	COG0534	Mate efflux family protein
C4N11_RS10960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4N11_RS10965	COG1132	(ABC) transporter
C4N11_RS10975	COG1132	(ABC) transporter
C4N11_RS10985	COG1438	arginine binding
C4N11_RS11005	COG0745	RESPONSE REGULATOR receiver
C4N11_RS11010	COG5002	protein histidine kinase activity
C4N11_RS11015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4N11_RS11020	COG0573	inorganic phosphate transmembrane transporter activity
C4N11_RS11030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4N11_RS11035	COG0704	Plays a role in the regulation of phosphate uptake
C4N11_RS11055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4N11_RS11065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4N11_RS11080	COG0697	spore germination
C4N11_RS11085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4N11_RS11085	COG4499	WXG100 protein secretion system (Wss), protein YukC
C4N11_RS11095	COG2217	Heavy metal translocating P-type atpase
C4N11_RS11105	COG2226	methyltransferase
C4N11_RS11125	COG0058	SHG alpha-glucan phosphorylase activity
C4N11_RS11130	COG1640	4-alpha-glucanotransferase
C4N11_RS11135	COG2182	Extracellular solute-binding protein
C4N11_RS11140	COG1175	transmembrane transport
C4N11_RS11145	COG3833	ABC-type maltose transport systems, permease component
C4N11_RS11155	COG5521	maltodextrose utilization protein MalA
C4N11_RS11160	COG1609	Transcriptional regulator
C4N11_RS11180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4N11_RS11215	COG1476	TRANSCRIPTIONal
C4N11_RS11265	COG2151	metal-sulfur cluster biosynthetic enzyme
C4N11_RS11275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4N11_RS11280	COG3959	Transketolase, thiamine diphosphate binding domain
C4N11_RS11295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4N11_RS11315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4N11_RS11355	COG0383	alpha-mannosidase activity
C4N11_RS11365	COG3537	Alpha-1,2-mannosidase
C4N11_RS11390	COG0549	Belongs to the carbamate kinase family
C4N11_RS11395	COG1288	antiporter activity
C4N11_RS11400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4N11_RS11415	COG3064	Membrane
C4N11_RS11415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4N11_RS11415	COG3583	domain protein
C4N11_RS11430	COG1454	alcohol dehydrogenase
C4N11_RS11450	COG3716	PTS system mannose fructose sorbose family IID component
C4N11_RS11460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4N11_RS11480	COG1070	Carbohydrate kinase
C4N11_RS11490	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4N11_RS11490	COG3443	Belongs to the bacterial solute-binding protein 9 family
C4N11_RS11495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4N11_RS11500	COG1121	(ABC) transporter
C4N11_RS11505	COG1846	Transcriptional regulator
C4N11_RS11510	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C4N11_RS11520	COG1696	Membrane protein involved in D-alanine export
C4N11_RS11535	COG2211	Major facilitator Superfamily
C4N11_RS11570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4N11_RS11575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4N11_RS11595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4N11_RS11605	COG1755	Isoprenylcysteine carboxyl methyltransferase
C4N11_RS11610	COG5002	protein histidine kinase activity
C4N11_RS11615	COG0745	RESPONSE REGULATOR receiver
C4N11_RS11625	COG0542	response to heat
C4N11_RS11630	COG4463	regulation of RNA biosynthetic process
C4N11_RS11635	COG1116	anion transmembrane transporter activity
C4N11_RS11640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4N11_RS11645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4N11_RS11665	COG0305	Participates in initiation and elongation during chromosome replication
C4N11_RS11685	COG1040	competence protein
C4N11_RS11690	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C4N11_RS11695	COG1739	Uncharacterized protein family UPF0029
C4N11_RS11735	COG3942	CHAP domain
C4N11_RS11745	COG1792	Involved in formation and maintenance of cell shape
C4N11_RS11750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4N11_RS11755	COG1122	ATPase activity
C4N11_RS11760	COG1122	ATPase activity
C4N11_RS11765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4N11_RS11775	COG0612	Peptidase, M16
C4N11_RS11780	COG0612	Peptidase, M16
C4N11_RS11785	COG2501	S4 domain
C4N11_RS11795	COG0517	IMP dehydrogenase activity
C4N11_RS11795	COG0516	GMP reductase activity
C4N11_RS11800	COG0180	Tryptophanyl-tRNA synthetase
C4N11_RS11805	COG0488	(ABC) transporter
C4N11_RS11815	COG1511	domain protein
C4N11_RS11825	COG1511	domain protein
C4N11_RS11870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4N11_RS11875	COG1475	DNA binding
C4N11_RS12115	COG2274	protein secretion by the type I secretion system
C4N11_RS12140	COG2801	Transposase and inactivated derivatives
C4N11_RS12170	COG0560	Phosphoserine phosphatase
C4N11_RS12175	COG0560	Phosphoserine phosphatase
C4N11_RS12225	COG2801	Transposase and inactivated derivatives