locus-tag	class	description
HMPREF1038_RS00015	COG0592	DNA-directed DNA polymerase activity
HMPREF1038_RS00025	COG0012	GTP binding
HMPREF1038_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMPREF1038_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMPREF1038_RS00065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMPREF1038_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF1038_RS00270	COG0582	viral genome integration into host DNA
HMPREF1038_RS00400	COG5263	repeat protein
HMPREF1038_RS00400	COG5632	N-Acetylmuramoyl-L-alanine amidase
HMPREF1038_RS00415	COG0756	dUTP diphosphatase activity
HMPREF1038_RS00425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF1038_RS00445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF1038_RS00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF1038_RS00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HMPREF1038_RS00470	COG1832	CoA-binding protein
HMPREF1038_RS00480	COG2855	membrane
HMPREF1038_RS00485	COG0436	Aminotransferase
HMPREF1038_RS00500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF1038_RS00525	COG2274	protein secretion by the type I secretion system
HMPREF1038_RS00530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF1038_RS00540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF1038_RS00555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMPREF1038_RS00570	COG0151	Belongs to the GarS family
HMPREF1038_RS00575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF1038_RS00590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF1038_RS00595	COG3583	domain protein
HMPREF1038_RS00595	COG3064	Membrane
HMPREF1038_RS00595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF1038_RS00610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS00615	COG3715	PTS system
HMPREF1038_RS00620	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF1038_RS00630	COG2222	sugar isomerase
HMPREF1038_RS00640	COG2514	catechol 2,3-dioxygenase activity
HMPREF1038_RS00645	COG1937	Protein conserved in bacteria
HMPREF1038_RS00670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF1038_RS00675	COG0569	domain protein
HMPREF1038_RS00685	COG1215	transferase activity, transferring glycosyl groups
HMPREF1038_RS00710	COG5002	protein histidine kinase activity
HMPREF1038_RS00735	COG4209	transmembrane transport
HMPREF1038_RS00740	COG0395	ABC-type sugar transport system, permease component
HMPREF1038_RS00745	COG1653	transport
HMPREF1038_RS00775	COG1695	Transcriptional regulator
HMPREF1038_RS00800	COG0546	phosphoglycolate phosphatase activity
HMPREF1038_RS00805	COG1760	l-serine dehydratase
HMPREF1038_RS00810	COG1760	l-serine dehydratase
HMPREF1038_RS00835	COG1136	(ABC) transporter
HMPREF1038_RS00835	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS00840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS00925	COG0445	tRNA wobble uridine modification
HMPREF1038_RS00960	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF1038_RS01055	COG1396	sequence-specific DNA binding
HMPREF1038_RS01085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS01090	COG1464	Belongs to the NlpA lipoprotein family
HMPREF1038_RS01095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF1038_RS01100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF1038_RS01120	COG2972	Histidine kinase
HMPREF1038_RS01125	COG4753	response regulator
HMPREF1038_RS01125	COG2207	Transcriptional regulator
HMPREF1038_RS01135	COG1780	Probably involved in ribonucleotide reductase function
HMPREF1038_RS01165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF1038_RS01165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMPREF1038_RS01185	COG2818	Glycosylase
HMPREF1038_RS01210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF1038_RS01215	COG0006	proline dipeptidase activity
HMPREF1038_RS01220	COG1393	Belongs to the ArsC family
HMPREF1038_RS01245	COG0285	dihydrofolate synthase activity
HMPREF1038_RS01255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF1038_RS01285	COG0602	queuosine metabolic process
HMPREF1038_RS01320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF1038_RS01345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF1038_RS01385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF1038_RS01400	COG0201	protein transport
HMPREF1038_RS01410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF1038_RS01415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF1038_RS01425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF1038_RS01430	COG0202	RNA polymerase activity
HMPREF1038_RS01440	COG3830	Belongs to the UPF0237 family
HMPREF1038_RS01480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF1038_RS01485	COG1349	DNA-binding transcription factor activity
HMPREF1038_RS01495	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF1038_RS01500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS01505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS01510	COG1882	Formate acetyltransferase
HMPREF1038_RS01555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF1038_RS01560	COG4589	Belongs to the CDS family
HMPREF1038_RS01565	COG0750	zinc metalloprotease
HMPREF1038_RS01575	COG2723	6-phospho-beta-galactosidase activity
HMPREF1038_RS01580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF1038_RS01595	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF1038_RS01615	COG2176	DNA-directed DNA polymerase activity
HMPREF1038_RS01635	COG2309	aminopeptidase activity
HMPREF1038_RS01640	COG2261	transglycosylase associated protein
HMPREF1038_RS01650	COG1187	pseudouridine synthase activity
HMPREF1038_RS01660	COG3579	cysteine-type endopeptidase activity
HMPREF1038_RS01665	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF1038_RS01670	COG3715	PTS system
HMPREF1038_RS01680	COG1064	alcohol dehydrogenase
HMPREF1038_RS01685	COG0561	phosphatase activity
HMPREF1038_RS01690	COG2252	PERMEase
HMPREF1038_RS01700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF1038_RS01705	COG0285	dihydrofolate synthase activity
HMPREF1038_RS01715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF1038_RS01715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMPREF1038_RS01725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF1038_RS01745	COG2723	6-phospho-beta-galactosidase activity
HMPREF1038_RS01760	COG3711	transcriptional antiterminator
HMPREF1038_RS01760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF1038_RS01775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS01790	COG0386	Belongs to the glutathione peroxidase family
HMPREF1038_RS01795	COG5492	domain, Protein
HMPREF1038_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF1038_RS01830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HMPREF1038_RS01835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS01840	COG3715	PTS system
HMPREF1038_RS01845	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF1038_RS01860	COG1609	Transcriptional regulator
HMPREF1038_RS01890	COG4839	cell division protein FtsL
HMPREF1038_RS01895	COG0768	penicillin binding
HMPREF1038_RS01925	COG0366	Alpha amylase catalytic
HMPREF1038_RS01930	COG4166	transmembrane transport
HMPREF1038_RS01970	COG3944	biosynthesis protein
HMPREF1038_RS02030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMPREF1038_RS02040	COG1088	dTDP-glucose 4,6-dehydratase activity
HMPREF1038_RS02055	COG4372	Transposase
HMPREF1038_RS02060	COG4166	transmembrane transport
HMPREF1038_RS02065	COG0366	Alpha amylase catalytic
HMPREF1038_RS02070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF1038_RS02095	COG0116	Belongs to the methyltransferase superfamily
HMPREF1038_RS02105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF1038_RS02110	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS02160	COG4585	Histidine kinase
HMPREF1038_RS02165	COG2197	response regulator
HMPREF1038_RS02195	COG0582	viral genome integration into host DNA
HMPREF1038_RS02205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF1038_RS02210	COG0681	Belongs to the peptidase S26 family
HMPREF1038_RS02235	COG1115	amino acid carrier protein
HMPREF1038_RS02260	COG0527	aspartate kinase activity
HMPREF1038_RS02265	COG1024	Enoyl-CoA hydratase
HMPREF1038_RS02270	COG1846	Transcriptional regulator
HMPREF1038_RS02280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF1038_RS02290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF1038_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF1038_RS02300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HMPREF1038_RS02315	COG0439	Biotin carboxylase
HMPREF1038_RS02320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMPREF1038_RS02360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF1038_RS02375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HMPREF1038_RS02385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF1038_RS02395	COG1461	Dihydroxyacetone kinase
HMPREF1038_RS02400	COG0028	Belongs to the TPP enzyme family
HMPREF1038_RS02405	COG0440	acetolactate synthase activity
HMPREF1038_RS02425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMPREF1038_RS02440	COG0765	amino acid transport
HMPREF1038_RS02470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF1038_RS02475	COG1882	Formate acetyltransferase
HMPREF1038_RS02505	COG1846	Transcriptional regulator
HMPREF1038_RS02505	COG1940	carbohydrate kinase activity
HMPREF1038_RS02510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS02520	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF1038_RS02525	COG2723	6-phospho-beta-galactosidase activity
HMPREF1038_RS02530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS02530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS02535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMPREF1038_RS02540	COG0569	domain protein
HMPREF1038_RS02560	COG1122	ATPase activity
HMPREF1038_RS02575	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HMPREF1038_RS02580	COG0671	phosphoesterase, PA-phosphatase related
HMPREF1038_RS02590	COG1247	-acetyltransferase
HMPREF1038_RS02605	COG0504	CTP synthase activity
HMPREF1038_RS02610	COG1283	sodium-dependent phosphate transmembrane transporter activity
HMPREF1038_RS02630	COG0789	Transcriptional regulator
HMPREF1038_RS02635	COG0174	glutamine synthetase
HMPREF1038_RS02650	COG4974	Belongs to the 'phage' integrase family
HMPREF1038_RS02660	COG0732	type I restriction modification DNA specificity domain
HMPREF1038_RS02705	COG0484	heat shock protein binding
HMPREF1038_RS02715	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF1038_RS02720	COG1131	(ABC) transporter
HMPREF1038_RS02745	COG3290	protein histidine kinase activity
HMPREF1038_RS02755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF1038_RS02760	COG2274	protein secretion by the type I secretion system
HMPREF1038_RS02820	COG1266	CAAX protease self-immunity
HMPREF1038_RS02840	COG0195	Participates in both transcription termination and antitermination
HMPREF1038_RS02845	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HMPREF1038_RS02905	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF1038_RS02915	COG0525	valine-tRNA ligase activity
HMPREF1038_RS02930	COG2801	Transposase and inactivated derivatives
HMPREF1038_RS02965	COG3711	transcriptional antiterminator
HMPREF1038_RS02970	COG2190	(PTS) system
HMPREF1038_RS02970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS02970	COG1263	PTS System
HMPREF1038_RS02985	COG0456	acetyltransferase
HMPREF1038_RS02990	COG0072	phenylalanine-tRNA ligase activity
HMPREF1038_RS02990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF1038_RS03010	COG3620	sequence-specific DNA binding
HMPREF1038_RS03015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HMPREF1038_RS03030	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF1038_RS03035	COG1045	serine acetyltransferase
HMPREF1038_RS03045	COG0215	cysteine-tRNA ligase activity
HMPREF1038_RS03050	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HMPREF1038_RS03070	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS03075	COG1136	(ABC) transporter
HMPREF1038_RS03080	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS03085	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS03090	COG5002	protein histidine kinase activity
HMPREF1038_RS03095	COG0191	fructose-bisphosphate aldolase activity
HMPREF1038_RS03100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HMPREF1038_RS03110	COG0765	amino acid transport
HMPREF1038_RS03115	COG0765	amino acid transport
HMPREF1038_RS03120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS03130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMPREF1038_RS03130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HMPREF1038_RS03160	COG0322	excinuclease ABC activity
HMPREF1038_RS03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS03185	COG1573	uracil-dna glycosylase
HMPREF1038_RS03195	COG1114	Component of the transport system for branched-chain amino acids
HMPREF1038_RS03200	COG1363	Peptidase, m42
HMPREF1038_RS03245	COG4555	ABC transporter
HMPREF1038_RS03280	COG1404	Belongs to the peptidase S8 family
HMPREF1038_RS03300	COG3775	system Galactitol-specific IIC component
HMPREF1038_RS03310	COG3250	beta-galactosidase activity
HMPREF1038_RS03330	COG1242	4 iron, 4 sulfur cluster binding
HMPREF1038_RS03335	COG1242	4 iron, 4 sulfur cluster binding
HMPREF1038_RS03340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HMPREF1038_RS03365	COG0785	Cytochrome C biogenesis protein
HMPREF1038_RS03370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF1038_RS03375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF1038_RS03375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF1038_RS03380	COG2207	Transcriptional regulator
HMPREF1038_RS03380	COG4753	response regulator
HMPREF1038_RS03385	COG2972	Histidine kinase
HMPREF1038_RS03395	COG3064	Membrane
HMPREF1038_RS03400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF1038_RS03415	COG1940	carbohydrate kinase activity
HMPREF1038_RS03430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMPREF1038_RS03435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF1038_RS03440	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HMPREF1038_RS03450	COG0300	oxidoreductase activity
HMPREF1038_RS03465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMPREF1038_RS03475	COG1187	pseudouridine synthase activity
HMPREF1038_RS03480	COG1217	gtp-binding protein TYPA
HMPREF1038_RS03500	COG1136	(ABC) transporter
HMPREF1038_RS03515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HMPREF1038_RS03525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF1038_RS03550	COG1131	(ABC) transporter
HMPREF1038_RS03555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS03565	COG1126	abc transporter atp-binding protein
HMPREF1038_RS03575	COG0765	amino acid transport
HMPREF1038_RS03580	COG1304	FMN binding
HMPREF1038_RS03585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF1038_RS03590	COG1304	FMN binding
HMPREF1038_RS03600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HMPREF1038_RS03605	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF1038_RS03615	COG4172	Belongs to the ABC transporter superfamily
HMPREF1038_RS03625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF1038_RS03640	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF1038_RS03660	COG2217	Heavy metal translocating P-type atpase
HMPREF1038_RS03665	COG0028	Belongs to the TPP enzyme family
HMPREF1038_RS03675	COG3335	DDE superfamily endonuclease
HMPREF1038_RS03685	COG2723	6-phospho-beta-galactosidase activity
HMPREF1038_RS03690	COG1482	cell wall glycoprotein biosynthetic process
HMPREF1038_RS03695	COG0733	neurotransmitter:sodium symporter activity
HMPREF1038_RS03700	COG0789	Transcriptional regulator
HMPREF1038_RS03710	COG2081	HI0933 family
HMPREF1038_RS03715	COG1307	EDD domain protein, DegV family
HMPREF1038_RS03725	COG2131	deaminase
HMPREF1038_RS03730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF1038_RS03770	COG0617	tRNA 3'-terminal CCA addition
HMPREF1038_RS03770	COG0517	IMP dehydrogenase activity
HMPREF1038_RS03770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF1038_RS03775	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF1038_RS03780	COG2884	Cell division ATP-binding protein ftsE
HMPREF1038_RS03785	COG2177	Part of the ABC transporter FtsEX involved in
HMPREF1038_RS03790	COG1263	PTS System
HMPREF1038_RS03790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS03790	COG2190	(PTS) system
HMPREF1038_RS03800	COG0513	Belongs to the DEAD box helicase family
HMPREF1038_RS03810	COG0167	dihydroorotate dehydrogenase activity
HMPREF1038_RS03820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HMPREF1038_RS03825	COG4470	Protein conserved in bacteria
HMPREF1038_RS03840	COG0488	(ABC) transporter
HMPREF1038_RS03865	COG1837	Belongs to the UPF0109 family
HMPREF1038_RS03885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF1038_RS03885	COG1328	CTP reductase activity
HMPREF1038_RS03895	COG4443	Transcriptional Coactivator p15 (PC4)
HMPREF1038_RS03905	COG1268	BioY protein
HMPREF1038_RS03910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF1038_RS03915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMPREF1038_RS03920	COG1136	(ABC) transporter
HMPREF1038_RS03925	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS03930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF1038_RS03930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF1038_RS03945	COG4989	oxidoreductase activity
HMPREF1038_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF1038_RS03980	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS03985	COG5002	protein histidine kinase activity
HMPREF1038_RS04005	COG0772	Belongs to the SEDS family
HMPREF1038_RS04010	COG0693	protein deglycase activity
HMPREF1038_RS04020	COG0187	DNA topoisomerase II activity
HMPREF1038_RS04045	COG3335	DDE superfamily endonuclease
HMPREF1038_RS04070	COG2801	Transposase and inactivated derivatives
HMPREF1038_RS04080	COG0494	nUDIX hydrolase
HMPREF1038_RS04100	COG0542	response to heat
HMPREF1038_RS04105	COG4703	Protein of unknown function (DUF1797)
HMPREF1038_RS04110	COG0765	amino acid transport
HMPREF1038_RS04115	COG1126	abc transporter atp-binding protein
HMPREF1038_RS04120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF1038_RS04125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HMPREF1038_RS04145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HMPREF1038_RS04190	COG2813	Specifically methylates the guanine in position
HMPREF1038_RS04195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HMPREF1038_RS04205	COG0295	cytidine deaminase activity
HMPREF1038_RS04210	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF1038_RS04215	COG3845	ABC transporter
HMPREF1038_RS04220	COG4603	Belongs to the binding-protein-dependent transport system permease family
HMPREF1038_RS04225	COG1079	Belongs to the binding-protein-dependent transport system permease family
HMPREF1038_RS04245	COG2801	Transposase and inactivated derivatives
HMPREF1038_RS04255	COG0187	DNA topoisomerase II activity
HMPREF1038_RS04265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF1038_RS04270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF1038_RS04275	COG4166	transmembrane transport
HMPREF1038_RS04310	COG0539	negative regulation of cytoplasmic translation
HMPREF1038_RS04315	COG1956	GAF domain-containing protein
HMPREF1038_RS04320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF1038_RS04335	COG0719	Fe-S assembly protein
HMPREF1038_RS04340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF1038_RS04350	COG0719	Fe-S assembly protein
HMPREF1038_RS04360	COG1686	Belongs to the peptidase S11 family
HMPREF1038_RS04365	COG0628	permease
HMPREF1038_RS04375	COG1349	DNA-binding transcription factor activity
HMPREF1038_RS04380	COG1105	Belongs to the carbohydrate kinase PfkB family
HMPREF1038_RS04385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF1038_RS04385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF1038_RS04385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF1038_RS04390	COG1674	ftsk spoiiie
HMPREF1038_RS04390	COG0697	spore germination
HMPREF1038_RS04400	COG1104	cysteine desulfurase activity
HMPREF1038_RS04465	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HMPREF1038_RS04475	COG1438	arginine binding
HMPREF1038_RS04495	COG0469	pyruvate kinase activity
HMPREF1038_RS04500	COG0582	viral genome integration into host DNA
HMPREF1038_RS04535	COG3689	TIGRFAM TIGR03943 family protein
HMPREF1038_RS04540	COG0701	Predicted permease
HMPREF1038_RS04550	COG2183	response to ionizing radiation
HMPREF1038_RS04575	COG1136	(ABC) transporter
HMPREF1038_RS04580	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS04600	COG1982	Orn Lys Arg decarboxylase major
HMPREF1038_RS04615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HMPREF1038_RS04635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMPREF1038_RS04640	COG0561	phosphatase activity
HMPREF1038_RS04660	COG0583	DNA-binding transcription factor activity
HMPREF1038_RS04665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF1038_RS04670	COG0564	pseudouridine synthase activity
HMPREF1038_RS04675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HMPREF1038_RS04690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF1038_RS04700	COG0470	DNA polymerase III
HMPREF1038_RS04745	COG0528	UMP kinase activity
HMPREF1038_RS04755	COG2996	Protein conserved in bacteria
HMPREF1038_RS04765	COG1702	phosphate starvation-inducible protein PhoH
HMPREF1038_RS04780	COG0686	Belongs to the AlaDH PNT family
HMPREF1038_RS04785	COG0686	Belongs to the AlaDH PNT family
HMPREF1038_RS04790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF1038_RS04795	COG1555	photosystem II stabilization
HMPREF1038_RS04795	COG1596	polysaccharide export
HMPREF1038_RS04800	COG2333	competence protein COMEC
HMPREF1038_RS04800	COG0658	competence protein
HMPREF1038_RS04810	COG1131	(ABC) transporter
HMPREF1038_RS04840	COG0543	2 iron, 2 sulfur cluster binding
HMPREF1038_RS04845	COG0167	dihydroorotate dehydrogenase activity
HMPREF1038_RS04850	COG4193	domain, Protein
HMPREF1038_RS04850	COG5263	repeat protein
HMPREF1038_RS04855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HMPREF1038_RS04865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HMPREF1038_RS04875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMPREF1038_RS04880	COG0237	dephospho-CoA kinase activity
HMPREF1038_RS04885	COG2814	Major facilitator Superfamily
HMPREF1038_RS04890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF1038_RS04900	COG0557	exoribonuclease II activity
HMPREF1038_RS04910	COG3615	Tellurite resistance protein tehB
HMPREF1038_RS04910	COG0500	methyltransferase
HMPREF1038_RS04925	COG4122	O-methyltransferase activity
HMPREF1038_RS04935	COG2801	Transposase and inactivated derivatives
HMPREF1038_RS04955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF1038_RS04975	COG0494	nUDIX hydrolase
HMPREF1038_RS04985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMPREF1038_RS04995	COG2176	DNA-directed DNA polymerase activity
HMPREF1038_RS05000	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF1038_RS05025	COG0785	Cytochrome C biogenesis protein
HMPREF1038_RS05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF1038_RS05035	COG0531	amino acid
HMPREF1038_RS05040	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF1038_RS05040	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF1038_RS05055	COG1011	Hydrolase
HMPREF1038_RS05070	COG1051	belongs to the nudix hydrolase family
HMPREF1038_RS05075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF1038_RS05085	COG0534	Mate efflux family protein
HMPREF1038_RS05090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HMPREF1038_RS05095	COG0022	dehydrogenase e1 component
HMPREF1038_RS05100	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF1038_RS05105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF1038_RS05110	COG0095	Lipoate-protein ligase
HMPREF1038_RS05130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF1038_RS05135	COG3064	Membrane
HMPREF1038_RS05140	COG3583	domain protein
HMPREF1038_RS05140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HMPREF1038_RS05150	COG1074	ATP-dependent DNA helicase activity
HMPREF1038_RS05165	COG0582	viral genome integration into host DNA
HMPREF1038_RS05190	COG0560	Phosphoserine phosphatase
HMPREF1038_RS05200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF1038_RS05210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF1038_RS05215	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF1038_RS05230	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF1038_RS05250	COG0488	(ABC) transporter
HMPREF1038_RS05260	COG1307	EDD domain protein, DegV family
HMPREF1038_RS05265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF1038_RS05270	COG0196	riboflavin kinase activity
HMPREF1038_RS05325	COG0280	phosphate acetyltransferase
HMPREF1038_RS05330	COG0564	pseudouridine synthase activity
HMPREF1038_RS05340	COG2357	RelA SpoT domain protein
HMPREF1038_RS05350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF1038_RS05355	COG1104	cysteine desulfurase activity
HMPREF1038_RS05375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF1038_RS05385	COG0210	DNA helicase
HMPREF1038_RS05405	COG0024	Methionine aminopeptidase
HMPREF1038_RS05410	COG4109	DRTGG domain
HMPREF1038_RS05420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF1038_RS05445	COG0438	transferase activity, transferring glycosyl groups
HMPREF1038_RS05450	COG0438	transferase activity, transferring glycosyl groups
HMPREF1038_RS05455	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF1038_RS05460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF1038_RS05465	COG0358	DNA primase activity
HMPREF1038_RS05470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF1038_RS05485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMPREF1038_RS05490	COG0772	Belongs to the SEDS family
HMPREF1038_RS05500	COG1396	sequence-specific DNA binding
HMPREF1038_RS05520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF1038_RS05575	COG0613	PHP domain protein
HMPREF1038_RS05580	COG0542	response to heat
HMPREF1038_RS05585	COG1396	sequence-specific DNA binding
HMPREF1038_RS05605	COG1597	lipid kinase activity
HMPREF1038_RS05635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HMPREF1038_RS05685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF1038_RS05690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF1038_RS05710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF1038_RS05720	COG0741	lytic transglycosylase activity
HMPREF1038_RS05730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMPREF1038_RS05745	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF1038_RS05755	COG1435	thymidine kinase activity
HMPREF1038_RS05760	COG1942	4-Oxalocrotonate Tautomerase
HMPREF1038_RS05775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HMPREF1038_RS05785	COG4708	membrane
HMPREF1038_RS05795	COG1970	mechanosensitive ion channel activity
HMPREF1038_RS05800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HMPREF1038_RS05845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF1038_RS05850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HMPREF1038_RS05855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF1038_RS05860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF1038_RS05870	COG2723	6-phospho-beta-galactosidase activity
HMPREF1038_RS05885	COG3711	transcriptional antiterminator
HMPREF1038_RS05890	COG3684	Belongs to the aldolase LacD family
HMPREF1038_RS05945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HMPREF1038_RS05950	COG0497	DNA recombination
HMPREF1038_RS05955	COG1438	arginine binding
HMPREF1038_RS05960	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HMPREF1038_RS05975	COG1570	exodeoxyribonuclease VII activity
HMPREF1038_RS05995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF1038_RS06015	COG3764	Sortase (surface protein transpeptidase)
HMPREF1038_RS06020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF1038_RS06030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HMPREF1038_RS06045	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HMPREF1038_RS06050	COG5002	protein histidine kinase activity
HMPREF1038_RS06055	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS06060	COG1194	a g-specific adenine glycosylase
HMPREF1038_RS06075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMPREF1038_RS06080	COG4684	Psort location CytoplasmicMembrane, score
HMPREF1038_RS06090	COG1827	regulation of RNA biosynthetic process
HMPREF1038_RS06095	COG2816	NAD+ diphosphatase activity
HMPREF1038_RS06120	COG0765	amino acid transport
HMPREF1038_RS06125	COG1126	abc transporter atp-binding protein
HMPREF1038_RS06130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HMPREF1038_RS06135	COG0552	protein localization to endoplasmic reticulum
HMPREF1038_RS06140	COG0561	phosphatase activity
HMPREF1038_RS06145	COG0561	phosphatase activity
HMPREF1038_RS06150	COG1196	nuclear chromosome segregation
HMPREF1038_RS06175	COG1401	restriction endodeoxyribonuclease activity
HMPREF1038_RS06185	COG0066	3-isopropylmalate dehydratase activity
HMPREF1038_RS06195	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF1038_RS06210	COG3142	Participates in the control of copper homeostasis
HMPREF1038_RS06215	COG2832	Protein of unknown function (DUF454)
HMPREF1038_RS06220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF1038_RS06230	COG0758	DNA mediated transformation
HMPREF1038_RS06235	COG4750	Nucleotidyl transferase
HMPREF1038_RS06250	COG1063	alcohol dehydrogenase
HMPREF1038_RS06265	COG3475	LICD family
HMPREF1038_RS06270	COG3475	LICD family
HMPREF1038_RS06280	COG0505	Belongs to the CarA family
HMPREF1038_RS06295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMPREF1038_RS06305	COG0488	(ABC) transporter
HMPREF1038_RS06315	COG1704	LemA family
HMPREF1038_RS06330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMPREF1038_RS06345	COG1078	dGTPase activity
HMPREF1038_RS06370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF1038_RS06375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMPREF1038_RS06380	COG0077	Prephenate dehydratase
HMPREF1038_RS06380	COG1605	Chorismate mutase
HMPREF1038_RS06385	COG0716	FMN binding
HMPREF1038_RS06390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMPREF1038_RS06415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF1038_RS06450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF1038_RS06455	COG0295	cytidine deaminase activity
HMPREF1038_RS06460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HMPREF1038_RS06470	COG4608	Belongs to the ABC transporter superfamily
HMPREF1038_RS06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF1038_RS06485	COG0601	transmembrane transport
HMPREF1038_RS06500	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HMPREF1038_RS06545	COG0270	DNA (cytosine-5-)-methyltransferase activity
HMPREF1038_RS06565	COG0402	S-adenosylhomocysteine deaminase activity
HMPREF1038_RS06575	COG1132	(ABC) transporter
HMPREF1038_RS06580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF1038_RS06580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF1038_RS06615	COG1215	transferase activity, transferring glycosyl groups
HMPREF1038_RS06625	COG3475	LICD family
HMPREF1038_RS06635	COG0077	Prephenate dehydratase
HMPREF1038_RS06640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF1038_RS06655	COG0287	Prephenate dehydrogenase
HMPREF1038_RS06680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMPREF1038_RS06690	COG1131	(ABC) transporter
HMPREF1038_RS06730	COG3842	ATPase activity
HMPREF1038_RS06745	COG3527	Alpha-acetolactate decarboxylase
HMPREF1038_RS06750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF1038_RS06755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS06760	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF1038_RS06765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF1038_RS06770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF1038_RS06775	COG0581	inorganic phosphate transmembrane transporter activity
HMPREF1038_RS06780	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF1038_RS06785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF1038_RS06790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF1038_RS06790	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HMPREF1038_RS06795	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF1038_RS06805	COG1393	Belongs to the ArsC family
HMPREF1038_RS06815	COG0647	UMP catabolic process
HMPREF1038_RS06825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMPREF1038_RS06875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF1038_RS06885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMPREF1038_RS06905	COG1131	(ABC) transporter
HMPREF1038_RS06915	COG0826	peptidase U32
HMPREF1038_RS06945	COG1132	(ABC) transporter
HMPREF1038_RS06960	COG1129	ABC transporter
HMPREF1038_RS06970	COG4372	Transposase
HMPREF1038_RS07000	COG2188	Transcriptional regulator
HMPREF1038_RS07005	COG0697	spore germination
HMPREF1038_RS07010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HMPREF1038_RS07025	COG0561	phosphatase activity
HMPREF1038_RS07060	COG0492	ferredoxin-NADP+ reductase activity
HMPREF1038_RS07070	COG1126	abc transporter atp-binding protein
HMPREF1038_RS07080	COG1393	Belongs to the ArsC family
HMPREF1038_RS07100	COG1272	protein, Hemolysin III
HMPREF1038_RS07130	COG0431	NADPH-dependent FMN reductase
HMPREF1038_RS07130	COG1053	succinate dehydrogenase
HMPREF1038_RS07130	COG3976	FMN-binding domain protein
HMPREF1038_RS07155	COG0656	L-ascorbic acid biosynthetic process
HMPREF1038_RS07160	COG0726	polysaccharide deacetylase
HMPREF1038_RS07185	COG3335	DDE superfamily endonuclease
HMPREF1038_RS07200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF1038_RS07235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF1038_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF1038_RS07250	COG1126	abc transporter atp-binding protein
HMPREF1038_RS07265	COG0628	permease
HMPREF1038_RS07270	COG2706	6-phosphogluconolactonase activity
HMPREF1038_RS07335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF1038_RS07360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF1038_RS07365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMPREF1038_RS07370	COG0626	cystathionine gamma-synthase activity
HMPREF1038_RS07375	COG1132	(ABC) transporter
HMPREF1038_RS07385	COG1132	(ABC) transporter
HMPREF1038_RS07390	COG4166	transmembrane transport
HMPREF1038_RS07395	COG2244	polysaccharide biosynthetic process
HMPREF1038_RS07400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF1038_RS07430	COG2827	Endonuclease containing a URI domain
HMPREF1038_RS07435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HMPREF1038_RS07440	COG1098	S1 RNA binding domain
HMPREF1038_RS07450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF1038_RS07455	COG0629	single-stranded DNA binding
HMPREF1038_RS07465	COG0017	Asparaginyl-tRNA synthetase
HMPREF1038_RS07475	COG0436	Aminotransferase
HMPREF1038_RS07510	COG0242	peptide deformylase activity
HMPREF1038_RS07515	COG0625	glutathione transferase activity
HMPREF1038_RS07525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF1038_RS07530	COG0488	(ABC) transporter
HMPREF1038_RS07545	COG1307	EDD domain protein, DegV family
HMPREF1038_RS07565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HMPREF1038_RS07580	COG1481	regulation of sporulation
HMPREF1038_RS07585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF1038_RS07595	COG0251	oxidation-reduction process
HMPREF1038_RS07615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HMPREF1038_RS07625	COG4193	domain, Protein
HMPREF1038_RS07625	COG5263	repeat protein
HMPREF1038_RS07635	COG3935	DnaD domain protein
HMPREF1038_RS07650	COG2226	methyltransferase
HMPREF1038_RS07660	COG3842	ATPase activity
HMPREF1038_RS07670	COG1335	isochorismatase
HMPREF1038_RS07680	COG0513	Belongs to the DEAD box helicase family
HMPREF1038_RS07685	COG2223	nitrite transmembrane transporter activity
HMPREF1038_RS07690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF1038_RS07695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF1038_RS07700	COG3442	glutamine amidotransferase
HMPREF1038_RS07705	COG0006	proline dipeptidase activity
HMPREF1038_RS07710	COG2801	Transposase and inactivated derivatives
HMPREF1038_RS07730	COG4720	Psort location CytoplasmicMembrane, score
HMPREF1038_RS07735	COG0351	phosphomethylpyrimidine kinase
HMPREF1038_RS07760	COG2824	Alkylphosphonate utilization operon protein PhnA
HMPREF1038_RS07780	COG0463	Glycosyl transferase, family 2
HMPREF1038_RS07785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMPREF1038_RS07790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMPREF1038_RS07795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMPREF1038_RS07800	COG2384	SAM-dependent methyltransferase
HMPREF1038_RS07810	COG2801	Transposase and inactivated derivatives
HMPREF1038_RS07830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMPREF1038_RS07835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF1038_RS07840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF1038_RS07840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF1038_RS07840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HMPREF1038_RS07845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF1038_RS07865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF1038_RS07870	COG0204	Acyl-transferase
HMPREF1038_RS07885	COG2910	NAD(P)H-binding
HMPREF1038_RS07905	COG5002	protein histidine kinase activity
HMPREF1038_RS07910	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS07925	COG1959	2 iron, 2 sulfur cluster binding
HMPREF1038_RS07980	COG3590	peptidase
HMPREF1038_RS07995	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF1038_RS08000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HMPREF1038_RS08010	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS08010	COG1136	(ABC) transporter
HMPREF1038_RS08055	COG3599	regulation of cell shape
HMPREF1038_RS08075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF1038_RS08095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF1038_RS08110	COG0768	penicillin binding
HMPREF1038_RS08125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF1038_RS08145	COG2731	YhcH YjgK YiaL family protein
HMPREF1038_RS08150	COG0395	ABC-type sugar transport system, permease component
HMPREF1038_RS08155	COG1175	transmembrane transport
HMPREF1038_RS08165	COG1263	PTS System
HMPREF1038_RS08165	COG2190	(PTS) system
HMPREF1038_RS08165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS08175	COG0673	inositol 2-dehydrogenase activity
HMPREF1038_RS08180	COG4409	exo-alpha-(2->6)-sialidase activity
HMPREF1038_RS08190	COG1175	transmembrane transport
HMPREF1038_RS08195	COG1653	transport
HMPREF1038_RS08215	COG3458	cephalosporin-C deacetylase activity
HMPREF1038_RS08220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMPREF1038_RS08235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF1038_RS08240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF1038_RS08245	COG0653	protein targeting
HMPREF1038_RS08255	COG1131	(ABC) transporter
HMPREF1038_RS08285	COG0778	Nitroreductase
HMPREF1038_RS08290	COG1484	DNA-dependent DNA replication
HMPREF1038_RS08305	COG1725	Transcriptional regulator
HMPREF1038_RS08310	COG1131	(ABC) transporter
HMPREF1038_RS08320	COG1668	transmembrane transport
HMPREF1038_RS08325	COG4152	abc transporter atp-binding protein
HMPREF1038_RS08345	COG1940	carbohydrate kinase activity
HMPREF1038_RS08350	COG2190	(PTS) system
HMPREF1038_RS08350	COG1263	PTS System
HMPREF1038_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS08360	COG1621	beta-fructofuranosidase activity
HMPREF1038_RS08365	COG1609	Transcriptional regulator
HMPREF1038_RS08375	COG3425	synthase
HMPREF1038_RS08405	COG2815	serine threonine protein kinase
HMPREF1038_RS08405	COG0515	serine threonine protein kinase
HMPREF1038_RS08410	COG0631	protein serine/threonine phosphatase activity
HMPREF1038_RS08415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HMPREF1038_RS08415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF1038_RS08425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMPREF1038_RS08435	COG0194	GDP metabolic process
HMPREF1038_RS08450	COG2226	methyltransferase
HMPREF1038_RS08455	COG0799	negative regulation of ribosome biogenesis
HMPREF1038_RS08465	COG1713	HD superfamily hydrolase involved in NAD metabolism
HMPREF1038_RS08470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF1038_RS08475	COG1534	Rna-binding protein
HMPREF1038_RS08480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HMPREF1038_RS08495	COG0668	transmembrane transport
HMPREF1038_RS08520	COG3118	belongs to the thioredoxin family
HMPREF1038_RS08525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HMPREF1038_RS08535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF1038_RS08550	COG1131	(ABC) transporter
HMPREF1038_RS08555	COG0640	Transcriptional regulator
HMPREF1038_RS08560	COG1164	Oligoendopeptidase f
HMPREF1038_RS08565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPREF1038_RS08575	COG1051	belongs to the nudix hydrolase family
HMPREF1038_RS08610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF1038_RS08620	COG1621	beta-fructofuranosidase activity
HMPREF1038_RS08625	COG0395	ABC-type sugar transport system, permease component
HMPREF1038_RS08630	COG1175	transmembrane transport
HMPREF1038_RS08640	COG1609	Transcriptional regulator
HMPREF1038_RS08645	COG3711	transcriptional antiterminator
HMPREF1038_RS08670	COG3237	CsbD-like
HMPREF1038_RS08685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HMPREF1038_RS08695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS08700	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF1038_RS08705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS08720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS08725	COG1846	Transcriptional regulator
HMPREF1038_RS08725	COG1940	carbohydrate kinase activity
HMPREF1038_RS08735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HMPREF1038_RS08760	COG0135	phosphoribosylanthranilate isomerase activity
HMPREF1038_RS08775	COG0512	Glutamine amidotransferase of anthranilate synthase
HMPREF1038_RS08780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF1038_RS08805	COG1285	pathogenesis
HMPREF1038_RS08810	COG1178	ABC-type Fe3 transport system permease component
HMPREF1038_RS08835	COG5434	Belongs to the glycosyl hydrolase 28 family
HMPREF1038_RS08850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HMPREF1038_RS08855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HMPREF1038_RS08860	COG1132	(ABC) transporter
HMPREF1038_RS08865	COG1132	(ABC) transporter
HMPREF1038_RS08885	COG0708	Exodeoxyribonuclease III
HMPREF1038_RS08905	COG2233	PERMEase
HMPREF1038_RS08935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF1038_RS08940	COG1609	Transcriptional regulator
HMPREF1038_RS08945	COG1063	alcohol dehydrogenase
HMPREF1038_RS08950	COG0789	Transcriptional regulator
HMPREF1038_RS08955	COG1230	cation diffusion facilitator family transporter
HMPREF1038_RS08965	COG3201	nicotinamide mononucleotide transporter
HMPREF1038_RS08970	COG1174	glycine betaine transport
HMPREF1038_RS08995	COG1363	Peptidase, m42
HMPREF1038_RS09010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF1038_RS09015	COG4605	iron ion homeostasis
HMPREF1038_RS09020	COG4604	ABC transporter, ATP-binding protein
HMPREF1038_RS09025	COG4607	ABC-type enterochelin transport system periplasmic component
HMPREF1038_RS09035	COG1187	pseudouridine synthase activity
HMPREF1038_RS09055	COG0517	IMP dehydrogenase activity
HMPREF1038_RS09065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMPREF1038_RS09080	COG0366	Alpha amylase catalytic
HMPREF1038_RS09085	COG1263	PTS System
HMPREF1038_RS09085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS09090	COG2188	Transcriptional regulator
HMPREF1038_RS09095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF1038_RS09110	COG4608	Belongs to the ABC transporter superfamily
HMPREF1038_RS09115	COG0444	Belongs to the ABC transporter superfamily
HMPREF1038_RS09120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF1038_RS09125	COG0601	transmembrane transport
HMPREF1038_RS09130	COG4166	transmembrane transport
HMPREF1038_RS09140	COG0366	Alpha amylase catalytic
HMPREF1038_RS09145	COG0395	ABC-type sugar transport system, permease component
HMPREF1038_RS09150	COG1175	transmembrane transport
HMPREF1038_RS09155	COG1653	transport
HMPREF1038_RS09160	COG3345	alpha-galactosidase
HMPREF1038_RS09165	COG2207	Transcriptional regulator
HMPREF1038_RS09170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HMPREF1038_RS09170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HMPREF1038_RS09290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF1038_RS09325	COG4221	oxidoreductase activity
HMPREF1038_RS09330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF1038_RS09335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF1038_RS09370	COG1132	(ABC) transporter
HMPREF1038_RS09455	COG5263	repeat protein
HMPREF1038_RS09455	COG5632	N-Acetylmuramoyl-L-alanine amidase
HMPREF1038_RS09475	COG1316	TRANSCRIPTIONal
HMPREF1038_RS09485	COG0802	atpase or kinase
HMPREF1038_RS09505	COG1136	(ABC) transporter
HMPREF1038_RS09505	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS09535	COG1253	flavin adenine dinucleotide binding
HMPREF1038_RS09550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF1038_RS09560	COG3480	Lon protease (S16) C-terminal proteolytic domain
HMPREF1038_RS09565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF1038_RS09570	COG0742	ribosomal rna small subunit methyltransferase
HMPREF1038_RS09585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF1038_RS09590	COG1254	Belongs to the acylphosphatase family
HMPREF1038_RS09600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HMPREF1038_RS09610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF1038_RS09625	COG1564	THIamine pyrophosphokinase
HMPREF1038_RS09635	COG1162	GTPase activity
HMPREF1038_RS09680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HMPREF1038_RS09685	COG0084	hydrolase, TatD family'
HMPREF1038_RS09700	COG0436	Aminotransferase
HMPREF1038_RS09710	COG0589	response to stress
HMPREF1038_RS09715	COG0561	phosphatase activity
HMPREF1038_RS09720	COG0252	asparaginase activity
HMPREF1038_RS09730	COG1609	Transcriptional regulator
HMPREF1038_RS09735	COG2197	response regulator
HMPREF1038_RS09740	COG4585	Histidine kinase
HMPREF1038_RS09745	COG0842	Transport permease protein
HMPREF1038_RS09750	COG1131	(ABC) transporter
HMPREF1038_RS09850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF1038_RS09855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF1038_RS09860	COG0564	pseudouridine synthase activity
HMPREF1038_RS09870	COG0577	efflux transmembrane transporter activity
HMPREF1038_RS09885	COG0157	Belongs to the NadC ModD family
HMPREF1038_RS09895	COG4133	protoheme IX ABC transporter activity
HMPREF1038_RS09900	COG2188	Transcriptional regulator
HMPREF1038_RS09905	COG2723	6-phospho-beta-galactosidase activity
HMPREF1038_RS09910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HMPREF1038_RS09920	COG1447	Phosphotransferase system cellobiose-specific component IIA
HMPREF1038_RS09925	COG1454	alcohol dehydrogenase
HMPREF1038_RS09925	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF1038_RS09935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF1038_RS09945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMPREF1038_RS09965	COG3623	hexulose-6-phosphate isomerase
HMPREF1038_RS09975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF1038_RS09985	COG3037	sugar-specific permease SgaT UlaA
HMPREF1038_RS09995	COG1847	R3H domain protein
HMPREF1038_RS10000	COG0706	membrane insertase activity
HMPREF1038_RS10050	COG4537	Required for transformation and DNA binding
HMPREF1038_RS10055	COG1459	type II secretion system
HMPREF1038_RS10060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HMPREF1038_RS10070	COG1063	alcohol dehydrogenase
HMPREF1038_RS10095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF1038_RS10100	COG3759	membrane
HMPREF1038_RS10115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HMPREF1038_RS10115	COG0131	Imidazoleglycerol-phosphate dehydratase
HMPREF1038_RS10120	COG0534	Mate efflux family protein
HMPREF1038_RS10220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF1038_RS10235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF1038_RS10240	COG1132	(ABC) transporter
HMPREF1038_RS10250	COG1132	(ABC) transporter
HMPREF1038_RS10260	COG1438	arginine binding
HMPREF1038_RS10280	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS10285	COG5002	protein histidine kinase activity
HMPREF1038_RS10290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF1038_RS10295	COG0573	inorganic phosphate transmembrane transporter activity
HMPREF1038_RS10305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF1038_RS10310	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF1038_RS10330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HMPREF1038_RS10350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF1038_RS10365	COG0697	spore germination
HMPREF1038_RS10370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF1038_RS10370	COG4499	WXG100 protein secretion system (Wss), protein YukC
HMPREF1038_RS10380	COG2217	Heavy metal translocating P-type atpase
HMPREF1038_RS10390	COG2226	methyltransferase
HMPREF1038_RS10410	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF1038_RS10415	COG1640	4-alpha-glucanotransferase
HMPREF1038_RS10420	COG2182	Extracellular solute-binding protein
HMPREF1038_RS10425	COG1175	transmembrane transport
HMPREF1038_RS10430	COG3833	ABC-type maltose transport systems, permease component
HMPREF1038_RS10435	COG5521	maltodextrose utilization protein MalA
HMPREF1038_RS10440	COG1609	Transcriptional regulator
HMPREF1038_RS10450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HMPREF1038_RS10485	COG1476	TRANSCRIPTIONal
HMPREF1038_RS10515	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF1038_RS10530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF1038_RS10535	COG3959	Transketolase, thiamine diphosphate binding domain
HMPREF1038_RS10550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF1038_RS10570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF1038_RS10585	COG0383	alpha-mannosidase activity
HMPREF1038_RS10595	COG3537	Alpha-1,2-mannosidase
HMPREF1038_RS10615	COG0549	Belongs to the carbamate kinase family
HMPREF1038_RS10620	COG1288	antiporter activity
HMPREF1038_RS10625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF1038_RS10640	COG3064	Membrane
HMPREF1038_RS10640	COG3583	domain protein
HMPREF1038_RS10640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HMPREF1038_RS10650	COG1454	alcohol dehydrogenase
HMPREF1038_RS10670	COG3716	PTS system mannose fructose sorbose family IID component
HMPREF1038_RS10680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF1038_RS10700	COG1070	Carbohydrate kinase
HMPREF1038_RS10710	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF1038_RS10710	COG3443	Belongs to the bacterial solute-binding protein 9 family
HMPREF1038_RS10715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF1038_RS10720	COG1121	(ABC) transporter
HMPREF1038_RS10725	COG1846	Transcriptional regulator
HMPREF1038_RS10730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMPREF1038_RS10740	COG1696	Membrane protein involved in D-alanine export
HMPREF1038_RS10755	COG2211	Major facilitator Superfamily
HMPREF1038_RS10760	COG3344	reverse transcriptase
HMPREF1038_RS10780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF1038_RS10785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMPREF1038_RS10805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMPREF1038_RS10815	COG1755	Isoprenylcysteine carboxyl methyltransferase
HMPREF1038_RS10820	COG5002	protein histidine kinase activity
HMPREF1038_RS10825	COG0745	RESPONSE REGULATOR receiver
HMPREF1038_RS10830	COG0542	response to heat
HMPREF1038_RS10835	COG4463	regulation of RNA biosynthetic process
HMPREF1038_RS10840	COG1116	anion transmembrane transporter activity
HMPREF1038_RS10845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF1038_RS10850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF1038_RS10870	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF1038_RS10890	COG1040	competence protein
HMPREF1038_RS10895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HMPREF1038_RS10900	COG1739	Uncharacterized protein family UPF0029
HMPREF1038_RS10915	COG3335	DDE superfamily endonuclease
HMPREF1038_RS10935	COG3942	CHAP domain
HMPREF1038_RS10945	COG1792	Involved in formation and maintenance of cell shape
HMPREF1038_RS10950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HMPREF1038_RS10955	COG1122	ATPase activity
HMPREF1038_RS10960	COG1122	ATPase activity
HMPREF1038_RS10965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HMPREF1038_RS10975	COG0612	Peptidase, M16
HMPREF1038_RS10980	COG0612	Peptidase, M16
HMPREF1038_RS10985	COG2501	S4 domain
HMPREF1038_RS10995	COG0516	GMP reductase activity
HMPREF1038_RS10995	COG0517	IMP dehydrogenase activity
HMPREF1038_RS11000	COG0180	Tryptophanyl-tRNA synthetase
HMPREF1038_RS11005	COG0488	(ABC) transporter
HMPREF1038_RS11015	COG1511	domain protein
HMPREF1038_RS11025	COG1511	domain protein
HMPREF1038_RS11060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF1038_RS11065	COG1475	DNA binding