locus-tag	class	description
SPPN_RS00010	COG0592	DNA-directed DNA polymerase activity
SPPN_RS00020	COG0012	GTP binding
SPPN_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPPN_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPPN_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SPPN_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPPN_RS00325	COG0582	viral genome integration into host DNA
SPPN_RS00350	COG0740	serine-type endopeptidase activity
SPPN_RS00430	COG0756	dUTP diphosphatase activity
SPPN_RS00440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPPN_RS00455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPPN_RS00505	COG4372	Transposase
SPPN_RS00510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPPN_RS00510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPPN_RS00515	COG1832	CoA-binding protein
SPPN_RS00525	COG2855	membrane
SPPN_RS00530	COG0436	Aminotransferase
SPPN_RS00545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPPN_RS00550	COG0791	NLP P60 protein
SPPN_RS00690	COG1134	teichoic acid transport
SPPN_RS00690	COG1388	LysM domain
SPPN_RS00705	COG2274	protein secretion by the type I secretion system
SPPN_RS00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPPN_RS00720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPPN_RS00725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPPN_RS00730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPPN_RS00735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPPN_RS00750	COG0138	bifunctional purine biosynthesis protein purh
SPPN_RS00755	COG0151	Belongs to the GarS family
SPPN_RS00760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPPN_RS00775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPPN_RS00780	COG3583	domain protein
SPPN_RS00780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPPN_RS00780	COG3064	Membrane
SPPN_RS00795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPPN_RS00800	COG3715	PTS system
SPPN_RS00805	COG3716	PTS system mannose fructose sorbose family IID component
SPPN_RS00815	COG2222	sugar isomerase
SPPN_RS00825	COG2514	catechol 2,3-dioxygenase activity
SPPN_RS00835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPPN_RS00840	COG0569	domain protein
SPPN_RS00850	COG1215	transferase activity, transferring glycosyl groups
SPPN_RS00865	COG5002	protein histidine kinase activity
SPPN_RS00885	COG1396	sequence-specific DNA binding
SPPN_RS00900	COG4209	transmembrane transport
SPPN_RS00905	COG0395	ABC-type sugar transport system, permease component
SPPN_RS00910	COG1653	transport
SPPN_RS00915	COG1131	(ABC) transporter
SPPN_RS00965	COG1695	Transcriptional regulator
SPPN_RS00995	COG1760	l-serine dehydratase
SPPN_RS01000	COG1760	l-serine dehydratase
SPPN_RS01030	COG1131	(ABC) transporter
SPPN_RS01055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPPN_RS01060	COG0137	argininosuccinate synthase activity
SPPN_RS01110	COG0582	viral genome integration into host DNA
SPPN_RS01225	COG0494	nUDIX hydrolase
SPPN_RS01270	COG1214	PFAM Peptidase M22, glycoprotease
SPPN_RS01280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPPN_RS01285	COG1396	sequence-specific DNA binding
SPPN_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPPN_RS01315	COG1464	Belongs to the NlpA lipoprotein family
SPPN_RS01320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPPN_RS01325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPPN_RS01350	COG1674	ftsk spoiiie
SPPN_RS01355	COG2946	Replication initiation factor
SPPN_RS01385	COG0791	NLP P60 protein
SPPN_RS01385	COG0741	lytic transglycosylase activity
SPPN_RS01460	COG2011	ABC-type metal ion transport system permease component
SPPN_RS01475	COG2972	Histidine kinase
SPPN_RS01480	COG2207	Transcriptional regulator
SPPN_RS01480	COG4753	response regulator
SPPN_RS01490	COG1780	Probably involved in ribonucleotide reductase function
SPPN_RS01525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPPN_RS01525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPPN_RS01545	COG2818	Glycosylase
SPPN_RS01575	COG0488	(ABC) transporter
SPPN_RS01590	COG0519	Catalyzes the synthesis of GMP from XMP
SPPN_RS01615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPPN_RS01620	COG0006	proline dipeptidase activity
SPPN_RS01625	COG1393	Belongs to the ArsC family
SPPN_RS01650	COG0285	dihydrofolate synthase activity
SPPN_RS01660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPPN_RS01695	COG0602	queuosine metabolic process
SPPN_RS01715	COG0088	Forms part of the polypeptide exit tunnel
SPPN_RS01730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPPN_RS01755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SPPN_RS01795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPPN_RS01810	COG0201	protein transport
SPPN_RS01820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SPPN_RS01825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPPN_RS01835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPPN_RS01840	COG0202	RNA polymerase activity
SPPN_RS01850	COG3830	Belongs to the UPF0237 family
SPPN_RS01855	COG2848	UPF0210 protein
SPPN_RS01870	COG1178	ABC-type Fe3 transport system permease component
SPPN_RS01875	COG3842	ATPase activity
SPPN_RS01880	COG1840	ABC-type Fe3 transport system, periplasmic component
SPPN_RS01890	COG2972	Histidine kinase
SPPN_RS01935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPPN_RS01940	COG4589	Belongs to the CDS family
SPPN_RS01945	COG0750	zinc metalloprotease
SPPN_RS01955	COG2723	6-phospho-beta-galactosidase activity
SPPN_RS01960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SPPN_RS01965	COG2213	PTS system mannitol-specific
SPPN_RS01970	COG3711	transcriptional antiterminator
SPPN_RS01975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPPN_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPPN_RS02010	COG0765	amino acid transport
SPPN_RS02015	COG0765	amino acid transport
SPPN_RS02020	COG1126	abc transporter atp-binding protein
SPPN_RS02025	COG1523	belongs to the glycosyl hydrolase 13 family
SPPN_RS02050	COG2176	DNA-directed DNA polymerase activity
SPPN_RS02065	COG2309	aminopeptidase activity
SPPN_RS02080	COG1187	pseudouridine synthase activity
SPPN_RS02090	COG3579	cysteine-type endopeptidase activity
SPPN_RS02095	COG3716	PTS system mannose fructose sorbose family IID component
SPPN_RS02100	COG3715	PTS system
SPPN_RS02110	COG1064	alcohol dehydrogenase
SPPN_RS02120	COG3335	DDE superfamily endonuclease
SPPN_RS02125	COG3335	DDE superfamily endonuclease
SPPN_RS02130	COG4166	transmembrane transport
SPPN_RS02135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPPN_RS02160	COG0116	Belongs to the methyltransferase superfamily
SPPN_RS02170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SPPN_RS02175	COG0745	RESPONSE REGULATOR receiver
SPPN_RS02205	COG2801	Transposase and inactivated derivatives
SPPN_RS02230	COG3591	Belongs to the peptidase S1B family
SPPN_RS02245	COG2197	response regulator
SPPN_RS02250	COG4585	Histidine kinase
SPPN_RS02275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPPN_RS02290	COG4839	cell division protein FtsL
SPPN_RS02295	COG0768	penicillin binding
SPPN_RS02325	COG0366	Alpha amylase catalytic
SPPN_RS02330	COG4166	transmembrane transport
SPPN_RS02335	COG4166	transmembrane transport
SPPN_RS02340	COG0562	UDP-galactopyranose mutase
SPPN_RS02350	COG3335	DDE superfamily endonuclease
SPPN_RS02355	COG0561	phosphatase activity
SPPN_RS02360	COG2252	PERMEase
SPPN_RS02370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPPN_RS02375	COG0285	dihydrofolate synthase activity
SPPN_RS02385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SPPN_RS02385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPPN_RS02395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPPN_RS02465	COG4166	transmembrane transport
SPPN_RS02470	COG0601	transmembrane transport
SPPN_RS02475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPPN_RS02480	COG0444	Belongs to the ABC transporter superfamily
SPPN_RS02485	COG4608	Belongs to the ABC transporter superfamily
SPPN_RS02495	COG4120	Belongs to the binding-protein-dependent transport system permease family
SPPN_RS02500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPPN_RS02505	COG2188	Transcriptional regulator
SPPN_RS02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPPN_RS02510	COG1263	PTS System
SPPN_RS02515	COG0366	Alpha amylase catalytic
SPPN_RS02525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPPN_RS02530	COG0681	Belongs to the peptidase S26 family
SPPN_RS02560	COG5263	repeat protein
SPPN_RS02560	COG4193	domain, Protein
SPPN_RS02565	COG5263	repeat protein
SPPN_RS02565	COG4193	domain, Protein
SPPN_RS02575	COG1115	amino acid carrier protein
SPPN_RS02600	COG0527	aspartate kinase activity
SPPN_RS02605	COG1024	Enoyl-CoA hydratase
SPPN_RS02620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPPN_RS02630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPPN_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
SPPN_RS02640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPPN_RS02655	COG0439	Biotin carboxylase
SPPN_RS02660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPPN_RS02700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPPN_RS02715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SPPN_RS02725	COG1461	Dihydroxyacetone kinase
SPPN_RS02730	COG0028	Belongs to the TPP enzyme family
SPPN_RS02735	COG0440	acetolactate synthase activity
SPPN_RS02750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SPPN_RS02765	COG0765	amino acid transport
SPPN_RS02780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPPN_RS02785	COG1882	Formate acetyltransferase
SPPN_RS02815	COG1122	ATPase activity
SPPN_RS02830	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPPN_RS02835	COG0671	phosphoesterase, PA-phosphatase related
SPPN_RS02850	COG2814	Major facilitator Superfamily
SPPN_RS02870	COG0504	CTP synthase activity
SPPN_RS02875	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPPN_RS02900	COG0789	Transcriptional regulator
SPPN_RS02905	COG0174	glutamine synthetase
SPPN_RS02945	COG0519	Catalyzes the synthesis of GMP from XMP
SPPN_RS02975	COG0525	valine-tRNA ligase activity
SPPN_RS03000	COG3711	transcriptional antiterminator
SPPN_RS03005	COG1263	PTS System
SPPN_RS03005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPPN_RS03005	COG2190	(PTS) system
SPPN_RS03020	COG0456	acetyltransferase
SPPN_RS03025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPPN_RS03025	COG0072	phenylalanine-tRNA ligase activity
SPPN_RS03040	COG3620	sequence-specific DNA binding
SPPN_RS03060	COG1045	serine acetyltransferase
SPPN_RS03070	COG0215	cysteine-tRNA ligase activity
SPPN_RS03075	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPPN_RS03095	COG0577	efflux transmembrane transporter activity
SPPN_RS03105	COG1136	(ABC) transporter
SPPN_RS03110	COG0577	efflux transmembrane transporter activity
SPPN_RS03135	COG0745	RESPONSE REGULATOR receiver
SPPN_RS03140	COG5002	protein histidine kinase activity
SPPN_RS03145	COG0191	fructose-bisphosphate aldolase activity
SPPN_RS03150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPPN_RS03155	COG0765	amino acid transport
SPPN_RS03165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPPN_RS03165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPPN_RS03205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPPN_RS03225	COG1573	uracil-dna glycosylase
SPPN_RS03240	COG1114	Component of the transport system for branched-chain amino acids
SPPN_RS03245	COG1363	Peptidase, m42
SPPN_RS03280	COG4555	ABC transporter
SPPN_RS03300	COG1404	Belongs to the peptidase S8 family
SPPN_RS03330	COG3775	system Galactitol-specific IIC component
SPPN_RS03340	COG3250	beta-galactosidase activity
SPPN_RS03360	COG1242	4 iron, 4 sulfur cluster binding
SPPN_RS03365	COG1242	4 iron, 4 sulfur cluster binding
SPPN_RS03370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPPN_RS03390	COG0785	Cytochrome C biogenesis protein
SPPN_RS03395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPPN_RS03400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPPN_RS03400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPPN_RS03405	COG4753	response regulator
SPPN_RS03405	COG2207	Transcriptional regulator
SPPN_RS03410	COG2972	Histidine kinase
SPPN_RS03420	COG3064	Membrane
SPPN_RS03425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPPN_RS03440	COG1940	carbohydrate kinase activity
SPPN_RS03460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPPN_RS03465	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPPN_RS03475	COG0300	oxidoreductase activity
SPPN_RS03490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPPN_RS03500	COG1187	pseudouridine synthase activity
SPPN_RS03505	COG1217	gtp-binding protein TYPA
SPPN_RS03525	COG1136	(ABC) transporter
SPPN_RS03540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SPPN_RS03565	COG2205	protein histidine kinase activity
SPPN_RS03570	COG0745	RESPONSE REGULATOR receiver
SPPN_RS03575	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPPN_RS03580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPPN_RS03585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SPPN_RS03590	COG1304	FMN binding
SPPN_RS03600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPPN_RS03605	COG0352	thiamine-phosphate diphosphorylase activity
SPPN_RS03615	COG4172	Belongs to the ABC transporter superfamily
SPPN_RS03625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPPN_RS03640	COG0352	thiamine-phosphate diphosphorylase activity
SPPN_RS03660	COG2217	Heavy metal translocating P-type atpase
SPPN_RS03665	COG0028	Belongs to the TPP enzyme family
SPPN_RS03685	COG2723	6-phospho-beta-galactosidase activity
SPPN_RS03690	COG1482	cell wall glycoprotein biosynthetic process
SPPN_RS03695	COG0733	neurotransmitter:sodium symporter activity
SPPN_RS03700	COG0789	Transcriptional regulator
SPPN_RS03705	COG2081	HI0933 family
SPPN_RS03710	COG1307	EDD domain protein, DegV family
SPPN_RS03720	COG2131	deaminase
SPPN_RS03725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPPN_RS03765	COG0617	tRNA 3'-terminal CCA addition
SPPN_RS03765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPPN_RS03765	COG0517	IMP dehydrogenase activity
SPPN_RS03770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPPN_RS03775	COG2884	Cell division ATP-binding protein ftsE
SPPN_RS03780	COG2177	Part of the ABC transporter FtsEX involved in
SPPN_RS03785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPPN_RS03785	COG1263	PTS System
SPPN_RS03785	COG2190	(PTS) system
SPPN_RS03795	COG0513	Belongs to the DEAD box helicase family
SPPN_RS03805	COG0167	dihydroorotate dehydrogenase activity
SPPN_RS03820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SPPN_RS03825	COG4470	Protein conserved in bacteria
SPPN_RS03840	COG0488	(ABC) transporter
SPPN_RS03915	COG1328	CTP reductase activity
SPPN_RS03915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPPN_RS03925	COG4443	Transcriptional Coactivator p15 (PC4)
SPPN_RS03930	COG1268	BioY protein
SPPN_RS03945	COG1136	(ABC) transporter
SPPN_RS03955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPPN_RS03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPPN_RS03965	COG1136	(ABC) transporter
SPPN_RS03970	COG0577	efflux transmembrane transporter activity
SPPN_RS03975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPPN_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPPN_RS03990	COG4989	oxidoreductase activity
SPPN_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
SPPN_RS04030	COG0745	RESPONSE REGULATOR receiver
SPPN_RS04035	COG5002	protein histidine kinase activity
SPPN_RS04055	COG0772	Belongs to the SEDS family
SPPN_RS04070	COG0187	DNA topoisomerase II activity
SPPN_RS04100	COG1051	belongs to the nudix hydrolase family
SPPN_RS04105	COG0542	response to heat
SPPN_RS04110	COG4703	Protein of unknown function (DUF1797)
SPPN_RS04115	COG0765	amino acid transport
SPPN_RS04120	COG1126	abc transporter atp-binding protein
SPPN_RS04125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPPN_RS04130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPPN_RS04150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPPN_RS04175	COG0813	purine-nucleoside phosphorylase activity
SPPN_RS04200	COG2813	Specifically methylates the guanine in position
SPPN_RS04205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SPPN_RS04215	COG0295	cytidine deaminase activity
SPPN_RS04220	COG1744	ABC transporter substrate-binding protein PnrA-like
SPPN_RS04225	COG3845	ABC transporter
SPPN_RS04230	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPPN_RS04235	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPPN_RS04245	COG0187	DNA topoisomerase II activity
SPPN_RS04270	COG2184	nucleotidyltransferase activity
SPPN_RS04285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPPN_RS04290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPPN_RS04295	COG4166	transmembrane transport
SPPN_RS04330	COG0539	negative regulation of cytoplasmic translation
SPPN_RS04335	COG1956	GAF domain-containing protein
SPPN_RS04340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPPN_RS04355	COG0719	Fe-S assembly protein
SPPN_RS04360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPPN_RS04370	COG0719	Fe-S assembly protein
SPPN_RS04380	COG0628	permease
SPPN_RS04390	COG1349	DNA-binding transcription factor activity
SPPN_RS04395	COG1105	Belongs to the carbohydrate kinase PfkB family
SPPN_RS04400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPPN_RS04400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPPN_RS04400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPPN_RS04410	COG1674	ftsk spoiiie
SPPN_RS04410	COG0697	spore germination
SPPN_RS04420	COG1104	cysteine desulfurase activity
SPPN_RS04470	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SPPN_RS04475	COG1438	arginine binding
SPPN_RS04495	COG0469	pyruvate kinase activity
SPPN_RS04545	COG3689	TIGRFAM TIGR03943 family protein
SPPN_RS04550	COG0701	Predicted permease
SPPN_RS04565	COG2822	iron ion transport
SPPN_RS04570	COG2837	iron assimilation
SPPN_RS04575	COG0672	)-iron permease
SPPN_RS04580	COG0805	protein transport
SPPN_RS04585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPPN_RS04605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPPN_RS04610	COG0716	FMN binding
SPPN_RS04615	COG0077	Prephenate dehydratase
SPPN_RS04615	COG1605	Chorismate mutase
SPPN_RS04620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPPN_RS04625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPPN_RS04685	COG1078	dGTPase activity
SPPN_RS04700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPPN_RS04745	COG4869	propanediol catabolic process
SPPN_RS04780	COG1272	protein, Hemolysin III
SPPN_RS04795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPPN_RS04800	COG1393	Belongs to the ArsC family
SPPN_RS04810	COG1126	abc transporter atp-binding protein
SPPN_RS04820	COG0492	ferredoxin-NADP+ reductase activity
SPPN_RS04865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPPN_RS04875	COG0557	exoribonuclease II activity
SPPN_RS04900	COG4122	O-methyltransferase activity
SPPN_RS04920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPPN_RS04935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPPN_RS04940	COG0494	nUDIX hydrolase
SPPN_RS04950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPPN_RS04960	COG2176	DNA-directed DNA polymerase activity
SPPN_RS04965	COG0584	glycerophosphoryl diester phosphodiesterase
SPPN_RS04985	COG0785	Cytochrome C biogenesis protein
SPPN_RS04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPPN_RS04995	COG0531	amino acid
SPPN_RS05000	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPPN_RS05000	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPPN_RS05030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SPPN_RS05035	COG1970	mechanosensitive ion channel activity
SPPN_RS05045	COG4708	membrane
SPPN_RS05055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPPN_RS05065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPPN_RS05070	COG1942	4-Oxalocrotonate Tautomerase
SPPN_RS05075	COG1435	thymidine kinase activity
SPPN_RS05085	COG2890	protein-(glutamine-N5) methyltransferase activity
SPPN_RS05110	COG0741	lytic transglycosylase activity
SPPN_RS05120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPPN_RS05130	COG0772	Belongs to the SEDS family
SPPN_RS05135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SPPN_RS05160	COG0358	DNA primase activity
SPPN_RS05165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPPN_RS05170	COG2151	metal-sulfur cluster biosynthetic enzyme
SPPN_RS05175	COG0438	transferase activity, transferring glycosyl groups
SPPN_RS05180	COG0438	transferase activity, transferring glycosyl groups
SPPN_RS05185	COG1983	PspC domain protein
SPPN_RS05210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPPN_RS05220	COG4109	DRTGG domain
SPPN_RS05225	COG0024	Methionine aminopeptidase
SPPN_RS05235	COG0210	DNA helicase
SPPN_RS05245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPPN_RS05265	COG1104	cysteine desulfurase activity
SPPN_RS05270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPPN_RS05375	COG5263	repeat protein
SPPN_RS05375	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPPN_RS05395	COG2357	RelA SpoT domain protein
SPPN_RS05405	COG0564	pseudouridine synthase activity
SPPN_RS05410	COG0280	phosphate acetyltransferase
SPPN_RS05450	COG0196	riboflavin kinase activity
SPPN_RS05455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPPN_RS05460	COG1307	EDD domain protein, DegV family
SPPN_RS05470	COG0488	(ABC) transporter
SPPN_RS05490	COG1597	lipid kinase activity
SPPN_RS05495	COG1523	belongs to the glycosyl hydrolase 13 family
SPPN_RS05500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SPPN_RS05510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SPPN_RS05520	COG0560	Phosphoserine phosphatase
SPPN_RS05545	COG0582	viral genome integration into host DNA
SPPN_RS05575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPPN_RS05585	COG0038	chloride channel
SPPN_RS05600	COG0534	Mate efflux family protein
SPPN_RS05610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SPPN_RS05615	COG1051	belongs to the nudix hydrolase family
SPPN_RS05630	COG1011	Hydrolase
SPPN_RS05635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPPN_RS05640	COG1461	Dihydroxyacetone kinase
SPPN_RS05645	COG2376	Dihydroxyacetone kinase
SPPN_RS05650	COG1309	transcriptional regulator
SPPN_RS05655	COG2376	Dihydroxyacetone kinase
SPPN_RS05665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPPN_RS05670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPPN_RS05675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPPN_RS05680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPPN_RS05710	COG3711	transcriptional antiterminator
SPPN_RS05720	COG3684	Belongs to the aldolase LacD family
SPPN_RS05755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SPPN_RS05760	COG0497	DNA recombination
SPPN_RS05765	COG1438	arginine binding
SPPN_RS05770	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPPN_RS05805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPPN_RS05815	COG2873	o-acetylhomoserine
SPPN_RS05820	COG3764	Sortase (surface protein transpeptidase)
SPPN_RS05825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPPN_RS05830	COG0039	L-malate dehydrogenase activity
SPPN_RS05860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPPN_RS05870	COG0745	RESPONSE REGULATOR receiver
SPPN_RS05875	COG1194	a g-specific adenine glycosylase
SPPN_RS05890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPPN_RS05895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPPN_RS05900	COG4684	Psort location CytoplasmicMembrane, score
SPPN_RS05910	COG1827	regulation of RNA biosynthetic process
SPPN_RS05920	COG1879	ABC-type sugar transport system periplasmic component
SPPN_RS05925	COG1172	Belongs to the binding-protein-dependent transport system permease family
SPPN_RS05935	COG1869	D-ribose catabolic process
SPPN_RS05940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPPN_RS05945	COG1609	Transcriptional regulator
SPPN_RS05950	COG2816	NAD+ diphosphatase activity
SPPN_RS05965	COG0556	nucleotide-excision repair
SPPN_RS05975	COG0765	amino acid transport
SPPN_RS05980	COG1126	abc transporter atp-binding protein
SPPN_RS05985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPPN_RS05990	COG0552	protein localization to endoplasmic reticulum
SPPN_RS05995	COG0561	phosphatase activity
SPPN_RS06000	COG0561	phosphatase activity
SPPN_RS06025	COG4372	Transposase
SPPN_RS06050	COG4555	ABC transporter
SPPN_RS06085	COG1196	nuclear chromosome segregation
SPPN_RS06110	COG1401	restriction endodeoxyribonuclease activity
SPPN_RS06135	COG0473	3-isopropylmalate dehydrogenase activity
SPPN_RS06150	COG3142	Participates in the control of copper homeostasis
SPPN_RS06155	COG2832	Protein of unknown function (DUF454)
SPPN_RS06165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPPN_RS06180	COG0758	DNA mediated transformation
SPPN_RS06225	COG4750	Nucleotidyl transferase
SPPN_RS06240	COG1063	alcohol dehydrogenase
SPPN_RS06255	COG3475	LICD family
SPPN_RS06260	COG3475	LICD family
SPPN_RS06270	COG0505	Belongs to the CarA family
SPPN_RS06285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPPN_RS06300	COG0488	(ABC) transporter
SPPN_RS06305	COG0501	Belongs to the peptidase M48B family
SPPN_RS06310	COG1704	LemA family
SPPN_RS06350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SPPN_RS06370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SPPN_RS06375	COG1982	Orn Lys Arg decarboxylase major
SPPN_RS06385	COG0577	efflux transmembrane transporter activity
SPPN_RS06390	COG1136	(ABC) transporter
SPPN_RS06410	COG2183	response to ionizing radiation
SPPN_RS06420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPPN_RS06440	COG0658	competence protein
SPPN_RS06440	COG2333	competence protein COMEC
SPPN_RS06445	COG1555	photosystem II stabilization
SPPN_RS06445	COG1596	polysaccharide export
SPPN_RS06450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPPN_RS06455	COG1702	phosphate starvation-inducible protein PhoH
SPPN_RS06475	COG0528	UMP kinase activity
SPPN_RS06495	COG0470	DNA polymerase III
SPPN_RS06505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPPN_RS06520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPPN_RS06525	COG0564	pseudouridine synthase activity
SPPN_RS06530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPPN_RS06535	COG0583	DNA-binding transcription factor activity
SPPN_RS06550	COG0561	phosphatase activity
SPPN_RS06570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SPPN_RS06585	COG0402	S-adenosylhomocysteine deaminase activity
SPPN_RS06595	COG1132	(ABC) transporter
SPPN_RS06600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPPN_RS06600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPPN_RS06635	COG1215	transferase activity, transferring glycosyl groups
SPPN_RS06645	COG3475	LICD family
SPPN_RS06655	COG0077	Prephenate dehydratase
SPPN_RS06660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPPN_RS06680	COG0287	Prephenate dehydrogenase
SPPN_RS06705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPPN_RS06710	COG1368	sulfuric ester hydrolase activity
SPPN_RS06730	COG1131	(ABC) transporter
SPPN_RS06755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPPN_RS06760	COG1061	Type III restriction enzyme res subunit
SPPN_RS06765	COG1002	Type II restriction enzyme, methylase subunits
SPPN_RS06785	COG3842	ATPase activity
SPPN_RS06800	COG3527	Alpha-acetolactate decarboxylase
SPPN_RS06810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPPN_RS06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPPN_RS06820	COG0704	Plays a role in the regulation of phosphate uptake
SPPN_RS06825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPPN_RS06830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPPN_RS06835	COG0581	inorganic phosphate transmembrane transporter activity
SPPN_RS06840	COG0573	inorganic phosphate transmembrane transporter activity
SPPN_RS06845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPPN_RS06850	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPPN_RS06850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPPN_RS06865	COG1393	Belongs to the ArsC family
SPPN_RS06875	COG0647	UMP catabolic process
SPPN_RS06885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPPN_RS06920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SPPN_RS06960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPPN_RS06980	COG1131	(ABC) transporter
SPPN_RS06995	COG2188	Transcriptional regulator
SPPN_RS07000	COG0697	spore germination
SPPN_RS07005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPPN_RS07020	COG0561	phosphatase activity
SPPN_RS07030	COG2814	Major facilitator Superfamily
SPPN_RS07035	COG0237	dephospho-CoA kinase activity
SPPN_RS07040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SPPN_RS07050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPPN_RS07060	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPPN_RS07065	COG5263	repeat protein
SPPN_RS07065	COG4193	domain, Protein
SPPN_RS07070	COG0167	dihydroorotate dehydrogenase activity
SPPN_RS07075	COG0543	2 iron, 2 sulfur cluster binding
SPPN_RS07105	COG1131	(ABC) transporter
SPPN_RS07145	COG0656	L-ascorbic acid biosynthetic process
SPPN_RS07150	COG0726	polysaccharide deacetylase
SPPN_RS07170	COG0513	Belongs to the DEAD box helicase family
SPPN_RS07190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPPN_RS07220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPPN_RS07230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPPN_RS07235	COG1126	abc transporter atp-binding protein
SPPN_RS07250	COG0628	permease
SPPN_RS07255	COG2706	6-phosphogluconolactonase activity
SPPN_RS07315	COG3335	DDE superfamily endonuclease
SPPN_RS07325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPPN_RS07350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPPN_RS07355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SPPN_RS07360	COG0626	cystathionine gamma-synthase activity
SPPN_RS07370	COG4166	transmembrane transport
SPPN_RS07375	COG2244	polysaccharide biosynthetic process
SPPN_RS07380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPPN_RS07405	COG2827	Endonuclease containing a URI domain
SPPN_RS07410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPPN_RS07415	COG1098	S1 RNA binding domain
SPPN_RS07430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPPN_RS07435	COG0629	single-stranded DNA binding
SPPN_RS07445	COG0017	Asparaginyl-tRNA synthetase
SPPN_RS07455	COG0436	Aminotransferase
SPPN_RS07490	COG0242	peptide deformylase activity
SPPN_RS07495	COG0625	glutathione transferase activity
SPPN_RS07505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPPN_RS07510	COG0488	(ABC) transporter
SPPN_RS07515	COG0617	tRNA 3'-terminal CCA addition
SPPN_RS07525	COG1307	EDD domain protein, DegV family
SPPN_RS07545	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPPN_RS07555	COG0492	ferredoxin-NADP+ reductase activity
SPPN_RS07575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPPN_RS07585	COG0251	oxidation-reduction process
SPPN_RS07605	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPPN_RS07625	COG3935	DnaD domain protein
SPPN_RS07645	COG3842	ATPase activity
SPPN_RS07655	COG1335	isochorismatase
SPPN_RS07660	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPPN_RS07665	COG2826	transposase and inactivated derivatives, IS30 family
SPPN_RS07670	COG0513	Belongs to the DEAD box helicase family
SPPN_RS07675	COG2223	nitrite transmembrane transporter activity
SPPN_RS07680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPPN_RS07685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPPN_RS07690	COG3442	glutamine amidotransferase
SPPN_RS07695	COG0006	proline dipeptidase activity
SPPN_RS07705	COG3279	Response regulator of the LytR AlgR family
SPPN_RS07715	COG1131	(ABC) transporter
SPPN_RS07730	COG4720	Psort location CytoplasmicMembrane, score
SPPN_RS07735	COG0351	phosphomethylpyrimidine kinase
SPPN_RS07760	COG2824	Alkylphosphonate utilization operon protein PhnA
SPPN_RS07765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SPPN_RS07780	COG0463	Glycosyl transferase, family 2
SPPN_RS07785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPPN_RS07795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPPN_RS07810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPPN_RS07815	COG2384	SAM-dependent methyltransferase
SPPN_RS07820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SPPN_RS07825	COG0204	Acyl-transferase
SPPN_RS07855	COG5002	protein histidine kinase activity
SPPN_RS07860	COG0745	RESPONSE REGULATOR receiver
SPPN_RS07870	COG1959	2 iron, 2 sulfur cluster binding
SPPN_RS07935	COG3590	peptidase
SPPN_RS07945	COG2814	Major facilitator Superfamily
SPPN_RS07960	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPPN_RS07965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPPN_RS07975	COG0577	efflux transmembrane transporter activity
SPPN_RS07975	COG1136	(ABC) transporter
SPPN_RS07995	COG3599	regulation of cell shape
SPPN_RS08015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPPN_RS08035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPPN_RS08050	COG0768	penicillin binding
SPPN_RS08075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPPN_RS08095	COG2731	YhcH YjgK YiaL family protein
SPPN_RS08100	COG0395	ABC-type sugar transport system, permease component
SPPN_RS08105	COG1175	transmembrane transport
SPPN_RS08115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPPN_RS08115	COG1263	PTS System
SPPN_RS08115	COG2190	(PTS) system
SPPN_RS08125	COG0673	inositol 2-dehydrogenase activity
SPPN_RS08130	COG4409	exo-alpha-(2->6)-sialidase activity
SPPN_RS08140	COG1175	transmembrane transport
SPPN_RS08145	COG1653	transport
SPPN_RS08195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPPN_RS08210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPPN_RS08215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SPPN_RS08220	COG0653	protein targeting
SPPN_RS08260	COG1484	DNA-dependent DNA replication
SPPN_RS08275	COG1725	Transcriptional regulator
SPPN_RS08280	COG1131	(ABC) transporter
SPPN_RS08295	COG1131	(ABC) transporter
SPPN_RS08300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPPN_RS08305	COG0640	Transcriptional regulator
SPPN_RS08310	COG1164	Oligoendopeptidase f
SPPN_RS08315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPPN_RS08325	COG1051	belongs to the nudix hydrolase family
SPPN_RS08360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPPN_RS08370	COG1621	beta-fructofuranosidase activity
SPPN_RS08380	COG0395	ABC-type sugar transport system, permease component
SPPN_RS08385	COG4209	transmembrane transport
SPPN_RS08440	COG0512	Glutamine amidotransferase of anthranilate synthase
SPPN_RS08445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPPN_RS08470	COG1285	pathogenesis
SPPN_RS08475	COG1178	ABC-type Fe3 transport system permease component
SPPN_RS08495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPPN_RS08500	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPPN_RS08505	COG0704	Plays a role in the regulation of phosphate uptake
SPPN_RS08520	COG5434	Belongs to the glycosyl hydrolase 28 family
SPPN_RS08525	COG5434	Belongs to the glycosyl hydrolase 28 family
SPPN_RS08540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SPPN_RS08545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SPPN_RS08550	COG1132	(ABC) transporter
SPPN_RS08555	COG1132	(ABC) transporter
SPPN_RS08575	COG0640	Transcriptional regulator
SPPN_RS08585	COG0708	Exodeoxyribonuclease III
SPPN_RS08600	COG2233	PERMEase
SPPN_RS08640	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPPN_RS08645	COG0195	Participates in both transcription termination and antitermination
SPPN_RS08720	COG2274	protein secretion by the type I secretion system
SPPN_RS08725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPPN_RS08735	COG3290	protein histidine kinase activity
SPPN_RS08760	COG4473	ABC transporter
SPPN_RS08765	COG1131	(ABC) transporter
SPPN_RS08770	COG0537	adenosine 5'-monophosphoramidase activity
SPPN_RS08780	COG0484	heat shock protein binding
SPPN_RS08830	COG4974	Belongs to the 'phage' integrase family
SPPN_RS08930	COG0582	viral genome integration into host DNA
SPPN_RS08940	COG1132	(ABC) transporter
SPPN_RS08945	COG1380	Effector of murein hydrolase LrgA
SPPN_RS08950	COG1346	cytolysis
SPPN_RS08955	COG1668	transmembrane transport
SPPN_RS08960	COG4152	abc transporter atp-binding protein
SPPN_RS08980	COG1940	carbohydrate kinase activity
SPPN_RS08985	COG2190	(PTS) system
SPPN_RS08985	COG1263	PTS System
SPPN_RS08985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPPN_RS08990	COG1621	beta-fructofuranosidase activity
SPPN_RS08995	COG1609	Transcriptional regulator
SPPN_RS09005	COG3425	synthase
SPPN_RS09025	COG2815	serine threonine protein kinase
SPPN_RS09025	COG0515	serine threonine protein kinase
SPPN_RS09030	COG0631	protein serine/threonine phosphatase activity
SPPN_RS09035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPPN_RS09035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPPN_RS09045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPPN_RS09055	COG0194	GDP metabolic process
SPPN_RS09085	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPPN_RS09090	COG3759	membrane
SPPN_RS09110	COG0534	Mate efflux family protein
SPPN_RS09200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SPPN_RS09220	COG2226	methyltransferase
SPPN_RS09225	COG0799	negative regulation of ribosome biogenesis
SPPN_RS09230	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPPN_RS09235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SPPN_RS09240	COG1534	Rna-binding protein
SPPN_RS09245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPPN_RS09260	COG0668	transmembrane transport
SPPN_RS09265	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SPPN_RS09285	COG3118	belongs to the thioredoxin family
SPPN_RS09295	COG0720	synthase
SPPN_RS09310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPPN_RS09345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPPN_RS09350	COG1609	Transcriptional regulator
SPPN_RS09355	COG1063	alcohol dehydrogenase
SPPN_RS09360	COG0789	Transcriptional regulator
SPPN_RS09365	COG1230	cation diffusion facilitator family transporter
SPPN_RS09375	COG3201	nicotinamide mononucleotide transporter
SPPN_RS09380	COG1174	glycine betaine transport
SPPN_RS09400	COG1363	Peptidase, m42
SPPN_RS09405	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPPN_RS09410	COG4605	iron ion homeostasis
SPPN_RS09415	COG4604	ABC transporter, ATP-binding protein
SPPN_RS09420	COG4607	ABC-type enterochelin transport system periplasmic component
SPPN_RS09430	COG1187	pseudouridine synthase activity
SPPN_RS09460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SPPN_RS09480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPPN_RS09480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPPN_RS09525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPPN_RS09530	COG3231	kanamycin kinase activity
SPPN_RS09580	COG4221	oxidoreductase activity
SPPN_RS09585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPPN_RS09590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPPN_RS09630	COG1132	(ABC) transporter
SPPN_RS09700	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPPN_RS09700	COG5263	repeat protein
SPPN_RS09720	COG1316	TRANSCRIPTIONal
SPPN_RS09730	COG0802	atpase or kinase
SPPN_RS09785	COG0386	Belongs to the glutathione peroxidase family
SPPN_RS09815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPPN_RS09830	COG3711	transcriptional antiterminator
SPPN_RS09830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPPN_RS09845	COG2723	6-phospho-beta-galactosidase activity
SPPN_RS09870	COG1373	ATPase (AAA superfamily
SPPN_RS09895	COG0577	efflux transmembrane transporter activity
SPPN_RS09895	COG1136	(ABC) transporter
SPPN_RS09940	COG1253	flavin adenine dinucleotide binding
SPPN_RS09960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPPN_RS09970	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPPN_RS09980	COG0742	ribosomal rna small subunit methyltransferase
SPPN_RS09995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPPN_RS10000	COG1254	Belongs to the acylphosphatase family
SPPN_RS10010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPPN_RS10020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPPN_RS10035	COG1564	THIamine pyrophosphokinase
SPPN_RS10045	COG1162	GTPase activity
SPPN_RS10060	COG0577	efflux transmembrane transporter activity
SPPN_RS10060	COG1136	(ABC) transporter
SPPN_RS10085	COG0084	hydrolase, TatD family'
SPPN_RS10110	COG0436	Aminotransferase
SPPN_RS10120	COG0589	response to stress
SPPN_RS10130	COG0561	phosphatase activity
SPPN_RS10135	COG0252	asparaginase activity
SPPN_RS10145	COG1609	Transcriptional regulator
SPPN_RS10150	COG2197	response regulator
SPPN_RS10155	COG4585	Histidine kinase
SPPN_RS10165	COG1131	(ABC) transporter
SPPN_RS10200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPPN_RS10205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPPN_RS10220	COG0577	efflux transmembrane transporter activity
SPPN_RS10225	COG1136	(ABC) transporter
SPPN_RS10235	COG1454	alcohol dehydrogenase
SPPN_RS10235	COG1012	belongs to the aldehyde dehydrogenase family
SPPN_RS10245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPPN_RS10255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SPPN_RS10265	COG1847	R3H domain protein
SPPN_RS10270	COG0706	membrane insertase activity
SPPN_RS10300	COG0189	ligase activity
SPPN_RS10305	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPPN_RS10325	COG1396	sequence-specific DNA binding
SPPN_RS10350	COG4537	Required for transformation and DNA binding
SPPN_RS10355	COG1459	type II secretion system
SPPN_RS10360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPPN_RS10390	COG0166	Belongs to the GPI family
SPPN_RS10400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPPN_RS10405	COG1132	(ABC) transporter
SPPN_RS10410	COG1132	(ABC) transporter
SPPN_RS10420	COG1438	arginine binding
SPPN_RS10435	COG0745	RESPONSE REGULATOR receiver
SPPN_RS10440	COG5002	protein histidine kinase activity
SPPN_RS10445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPPN_RS10450	COG0573	inorganic phosphate transmembrane transporter activity
SPPN_RS10460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPPN_RS10465	COG0704	Plays a role in the regulation of phosphate uptake
SPPN_RS10485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPPN_RS10495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPPN_RS10510	COG0697	spore germination
SPPN_RS10515	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPPN_RS10515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPPN_RS10525	COG2217	Heavy metal translocating P-type atpase
SPPN_RS10535	COG2226	methyltransferase
SPPN_RS10565	COG2801	Transposase and inactivated derivatives
SPPN_RS10580	COG0058	SHG alpha-glucan phosphorylase activity
SPPN_RS10585	COG1640	4-alpha-glucanotransferase
SPPN_RS10590	COG2182	Extracellular solute-binding protein
SPPN_RS10595	COG1175	transmembrane transport
SPPN_RS10600	COG3833	ABC-type maltose transport systems, permease component
SPPN_RS10605	COG5521	maltodextrose utilization protein MalA
SPPN_RS10610	COG1609	Transcriptional regulator
SPPN_RS10620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPPN_RS10650	COG1476	TRANSCRIPTIONal
SPPN_RS10675	COG2151	metal-sulfur cluster biosynthetic enzyme
SPPN_RS10690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPPN_RS10695	COG3959	Transketolase, thiamine diphosphate binding domain
SPPN_RS10710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPPN_RS10730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPPN_RS10745	COG0732	type I restriction modification DNA specificity domain
SPPN_RS10755	COG3177	Filamentation induced by cAMP protein fic
SPPN_RS10765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPPN_RS10795	COG2801	Transposase and inactivated derivatives
SPPN_RS10935	COG0383	alpha-mannosidase activity
SPPN_RS10945	COG3537	Alpha-1,2-mannosidase
SPPN_RS10955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPPN_RS10975	COG3583	domain protein
SPPN_RS10990	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPPN_RS11000	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPPN_RS11000	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPPN_RS11005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPPN_RS11010	COG1121	(ABC) transporter
SPPN_RS11015	COG1846	Transcriptional regulator
SPPN_RS11020	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPPN_RS11030	COG1696	Membrane protein involved in D-alanine export
SPPN_RS11045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPPN_RS11050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPPN_RS11070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPPN_RS11085	COG3201	nicotinamide mononucleotide transporter
SPPN_RS11095	COG0542	response to heat
SPPN_RS11100	COG4463	regulation of RNA biosynthetic process
SPPN_RS11105	COG1116	anion transmembrane transporter activity
SPPN_RS11110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SPPN_RS11115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPPN_RS11135	COG0305	Participates in initiation and elongation during chromosome replication
SPPN_RS11155	COG1040	competence protein
SPPN_RS11160	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPPN_RS11165	COG1739	Uncharacterized protein family UPF0029
SPPN_RS11185	COG3942	CHAP domain
SPPN_RS11195	COG1792	Involved in formation and maintenance of cell shape
SPPN_RS11200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPPN_RS11205	COG1122	ATPase activity
SPPN_RS11210	COG1122	ATPase activity
SPPN_RS11215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPPN_RS11225	COG0612	Peptidase, M16
SPPN_RS11230	COG0612	Peptidase, M16
SPPN_RS11235	COG2501	S4 domain
SPPN_RS11245	COG0516	GMP reductase activity
SPPN_RS11245	COG0517	IMP dehydrogenase activity
SPPN_RS11250	COG0180	Tryptophanyl-tRNA synthetase
SPPN_RS11255	COG0488	(ABC) transporter
SPPN_RS11265	COG1511	domain protein
SPPN_RS11310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPPN_RS11315	COG1475	DNA binding
SPPN_RS11455	COG3250	beta-galactosidase activity
SPPN_RS11460	COG3250	beta-galactosidase activity