locus-tag	class	description
SP5448_RS00010	COG0592	DNA-directed DNA polymerase activity
SP5448_RS00020	COG0012	GTP binding
SP5448_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SP5448_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SP5448_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SP5448_RS00065	COG0531	amino acid
SP5448_RS00175	COG3942	CHAP domain
SP5448_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SP5448_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SP5448_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SP5448_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SP5448_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SP5448_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SP5448_RS00285	COG1454	alcohol dehydrogenase
SP5448_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
SP5448_RS00290	COG1064	alcohol dehydrogenase
SP5448_RS00295	COG0534	Mate efflux family protein
SP5448_RS00405	COG0201	protein transport
SP5448_RS00540	COG1121	(ABC) transporter
SP5448_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SP5448_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SP5448_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SP5448_RS00585	COG1459	type II secretion system
SP5448_RS00590	COG4537	Required for transformation and DNA binding
SP5448_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SP5448_RS00635	COG1363	Peptidase, m42
SP5448_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SP5448_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SP5448_RS00660	COG1428	Deoxynucleoside kinase
SP5448_RS00665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SP5448_RS00695	COG4509	Sortase family
SP5448_RS00705	COG4372	Transposase
SP5448_RS00730	COG2031	fatty acid transporter
SP5448_RS00750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SP5448_RS00765	COG0251	oxidation-reduction process
SP5448_RS00780	COG1269	ATP hydrolysis coupled proton transport
SP5448_RS00785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SP5448_RS00795	COG1527	subunit (C
SP5448_RS00800	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SP5448_RS00835	COG1744	ABC transporter substrate-binding protein PnrA-like
SP5448_RS00875	COG0626	cystathionine gamma-synthase activity
SP5448_RS00905	COG3623	hexulose-6-phosphate isomerase
SP5448_RS00925	COG4175	Glycine betaine
SP5448_RS00925	COG3448	diguanylate cyclase activity
SP5448_RS00935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SP5448_RS00935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SP5448_RS00955	COG3969	phosphoadenosine phosphosulfate
SP5448_RS00960	COG1475	DNA binding
SP5448_RS00970	COG2801	Transposase and inactivated derivatives
SP5448_RS00975	COG2801	Transposase and inactivated derivatives
SP5448_RS00990	COG0157	Belongs to the NadC ModD family
SP5448_RS00995	COG2801	Transposase and inactivated derivatives
SP5448_RS01015	COG1268	BioY protein
SP5448_RS01020	COG1234	tRNA 3'-trailer cleavage
SP5448_RS01050	COG5433	transposase activity
SP5448_RS01065	COG0705	Rhomboid family
SP5448_RS01065	COG0457	Tetratricopeptide repeat
SP5448_RS01085	COG1132	(ABC) transporter
SP5448_RS01090	COG1132	(ABC) transporter
SP5448_RS01100	COG0756	dUTP diphosphatase activity
SP5448_RS01125	COG3290	protein histidine kinase activity
SP5448_RS01150	COG1847	R3H domain protein
SP5448_RS01170	COG1175	transmembrane transport
SP5448_RS01175	COG0395	ABC-type sugar transport system, permease component
SP5448_RS01185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SP5448_RS01200	COG0084	hydrolase, TatD family'
SP5448_RS01225	COG1564	THIamine pyrophosphokinase
SP5448_RS01240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SP5448_RS01275	COG0765	amino acid transport
SP5448_RS01295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SP5448_RS01305	COG0719	Fe-S assembly protein
SP5448_RS01310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SP5448_RS01325	COG1686	Belongs to the peptidase S11 family
SP5448_RS01330	COG1686	Belongs to the peptidase S11 family
SP5448_RS01335	COG4166	transmembrane transport
SP5448_RS01340	COG0601	transmembrane transport
SP5448_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SP5448_RS01350	COG0444	Belongs to the ABC transporter superfamily
SP5448_RS01405	COG0351	phosphomethylpyrimidine kinase
SP5448_RS01410	COG4720	Psort location CytoplasmicMembrane, score
SP5448_RS01420	COG0668	transmembrane transport
SP5448_RS01460	COG5433	transposase activity
SP5448_RS01485	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SP5448_RS01500	COG0789	Transcriptional regulator
SP5448_RS01505	COG0174	glutamine synthetase
SP5448_RS01520	COG1214	PFAM Peptidase M22, glycoprotease
SP5448_RS01525	COG0456	acetyltransferase
SP5448_RS01545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SP5448_RS01550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SP5448_RS01560	COG2081	HI0933 family
SP5448_RS01575	COG0789	Transcriptional regulator
SP5448_RS01600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SP5448_RS01605	COG2814	Major facilitator Superfamily
SP5448_RS01610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SP5448_RS01625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SP5448_RS01630	COG1882	Formate acetyltransferase
SP5448_RS01645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SP5448_RS01650	COG0681	Belongs to the peptidase S26 family
SP5448_RS01680	COG3118	belongs to the thioredoxin family
SP5448_RS01690	COG1194	a g-specific adenine glycosylase
SP5448_RS01730	COG0006	proline dipeptidase activity
SP5448_RS01735	COG2131	deaminase
SP5448_RS01755	COG1609	Transcriptional regulator
SP5448_RS01760	COG1621	beta-fructofuranosidase activity
SP5448_RS01765	COG2190	(PTS) system
SP5448_RS01765	COG1263	PTS System
SP5448_RS01765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP5448_RS01775	COG1940	carbohydrate kinase activity
SP5448_RS01780	COG1482	cell wall glycoprotein biosynthetic process
SP5448_RS01785	COG5433	transposase activity
SP5448_RS01815	COG3942	CHAP domain
SP5448_RS01815	COG1388	LysM domain
SP5448_RS01840	COG1120	ATPase activity
SP5448_RS01845	COG4988	ABC transporter
SP5448_RS01850	COG1132	(ABC) transporter
SP5448_RS01865	COG1129	ABC transporter
SP5448_RS01870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SP5448_RS01885	COG0252	asparaginase activity
SP5448_RS01890	COG0561	phosphatase activity
SP5448_RS01900	COG0436	Aminotransferase
SP5448_RS01910	COG1335	isochorismatase
SP5448_RS01915	COG0574	Belongs to the PEP-utilizing enzyme family
SP5448_RS01915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SP5448_RS01940	COG2261	transglycosylase associated protein
SP5448_RS01945	COG0588	phosphoglycerate mutase activity
SP5448_RS01980	COG1024	Enoyl-CoA hydratase
SP5448_RS02005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SP5448_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
SP5448_RS02015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SP5448_RS02030	COG0439	Biotin carboxylase
SP5448_RS02055	COG3716	PTS system mannose fructose sorbose family IID component
SP5448_RS02060	COG3715	PTS system
SP5448_RS02070	COG0561	phosphatase activity
SP5448_RS02075	COG2252	PERMEase
SP5448_RS02080	COG0802	atpase or kinase
SP5448_RS02090	COG1316	TRANSCRIPTIONal
SP5448_RS02100	COG0537	adenosine 5'-monophosphoramidase activity
SP5448_RS02105	COG1131	(ABC) transporter
SP5448_RS02110	COG4473	ABC transporter
SP5448_RS02130	COG4974	Belongs to the 'phage' integrase family
SP5448_RS02245	COG1783	phage Terminase large subunit
SP5448_RS02365	COG1705	Flagellar rod assembly protein muramidase FlgJ
SP5448_RS02385	COG0195	Participates in both transcription termination and antitermination
SP5448_RS02390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SP5448_RS02420	COG2217	Heavy metal translocating P-type atpase
SP5448_RS02470	COG2860	membrane
SP5448_RS02475	COG0561	phosphatase activity
SP5448_RS02495	COG1283	sodium-dependent phosphate transmembrane transporter activity
SP5448_RS02505	COG0656	L-ascorbic acid biosynthetic process
SP5448_RS02510	COG1755	Isoprenylcysteine carboxyl methyltransferase
SP5448_RS02545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SP5448_RS02550	COG0446	pyridine nucleotide-disulphide oxidoreductase
SP5448_RS02575	COG1131	(ABC) transporter
SP5448_RS02615	COG0768	penicillin binding
SP5448_RS02625	COG0513	Belongs to the DEAD box helicase family
SP5448_RS02635	COG1126	abc transporter atp-binding protein
SP5448_RS02645	COG0492	ferredoxin-NADP+ reductase activity
SP5448_RS02650	COG1113	amino acid transport
SP5448_RS02655	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SP5448_RS02665	COG3579	cysteine-type endopeptidase activity
SP5448_RS02670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SP5448_RS02690	COG0116	Belongs to the methyltransferase superfamily
SP5448_RS02705	COG2610	gluconate transmembrane transporter activity
SP5448_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
SP5448_RS02720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SP5448_RS02725	COG0183	Belongs to the thiolase family
SP5448_RS02730	COG0583	DNA-binding transcription factor activity
SP5448_RS02750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SP5448_RS02760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SP5448_RS02760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SP5448_RS02770	COG0515	serine threonine protein kinase
SP5448_RS02770	COG2815	serine threonine protein kinase
SP5448_RS02780	COG4585	Histidine kinase
SP5448_RS02785	COG2197	response regulator
SP5448_RS02795	COG1098	S1 RNA binding domain
SP5448_RS02805	COG1739	Uncharacterized protein family UPF0029
SP5448_RS02810	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SP5448_RS02885	COG0383	alpha-mannosidase activity
SP5448_RS02900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SP5448_RS02905	COG2723	6-phospho-beta-galactosidase activity
SP5448_RS02910	COG1940	carbohydrate kinase activity
SP5448_RS02915	COG1175	transmembrane transport
SP5448_RS02920	COG0395	ABC-type sugar transport system, permease component
SP5448_RS02925	COG1653	transport
SP5448_RS02935	COG2972	Histidine kinase
SP5448_RS02940	COG2207	Transcriptional regulator
SP5448_RS02940	COG4753	response regulator
SP5448_RS02945	COG3250	beta-galactosidase activity
SP5448_RS02955	COG2226	methyltransferase
SP5448_RS02975	COG1605	Chorismate mutase
SP5448_RS02975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SP5448_RS03035	COG1518	maintenance of DNA repeat elements
SP5448_RS03040	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SP5448_RS03045	COG0785	Cytochrome C biogenesis protein
SP5448_RS03050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SP5448_RS03065	COG2972	Histidine kinase
SP5448_RS03090	COG2235	arginine
SP5448_RS03105	COG1288	antiporter activity
SP5448_RS03110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SP5448_RS03115	COG0549	Belongs to the carbamate kinase family
SP5448_RS03125	COG0742	ribosomal rna small subunit methyltransferase
SP5448_RS03135	COG3480	Lon protease (S16) C-terminal proteolytic domain
SP5448_RS03145	COG4470	Protein conserved in bacteria
SP5448_RS03160	COG0783	Belongs to the Dps family
SP5448_RS03170	COG1940	carbohydrate kinase activity
SP5448_RS03175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SP5448_RS03180	COG1217	gtp-binding protein TYPA
SP5448_RS03215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SP5448_RS03230	COG2302	S4 RNA-binding domain
SP5448_RS03235	COG3599	regulation of cell shape
SP5448_RS03250	COG0494	nUDIX hydrolase
SP5448_RS03255	COG0542	response to heat
SP5448_RS03260	COG4703	Protein of unknown function (DUF1797)
SP5448_RS03265	COG0765	amino acid transport
SP5448_RS03275	COG0415	Belongs to the DNA photolyase family
SP5448_RS03280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SP5448_RS03305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SP5448_RS03310	COG1438	arginine binding
SP5448_RS03315	COG0497	DNA recombination
SP5448_RS03330	COG2755	lipolytic protein G-D-S-L family
SP5448_RS03345	COG0582	viral genome integration into host DNA
SP5448_RS03360	COG1396	sequence-specific DNA binding
SP5448_RS03370	COG3561	AntA/AntB antirepressor
SP5448_RS03410	COG3935	DnaD domain protein
SP5448_RS03430	COG3723	Recombinational DNA repair protein, rece pathway
SP5448_RS03615	COG2217	Heavy metal translocating P-type atpase
SP5448_RS03630	COG1827	regulation of RNA biosynthetic process
SP5448_RS03640	COG2116	formate transmembrane transporter activity
SP5448_RS03645	COG0768	penicillin binding
SP5448_RS03660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SP5448_RS03675	COG0513	Belongs to the DEAD box helicase family
SP5448_RS03690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SP5448_RS03695	COG0204	Acyl-transferase
SP5448_RS03700	COG1555	photosystem II stabilization
SP5448_RS03700	COG1596	polysaccharide export
SP5448_RS03705	COG2333	competence protein COMEC
SP5448_RS03705	COG0658	competence protein
SP5448_RS03750	COG1187	pseudouridine synthase activity
SP5448_RS03765	COG2223	nitrite transmembrane transporter activity
SP5448_RS03770	COG4122	O-methyltransferase activity
SP5448_RS03785	COG1476	TRANSCRIPTIONal
SP5448_RS03800	COG2801	Transposase and inactivated derivatives
SP5448_RS03810	COG2801	Transposase and inactivated derivatives
SP5448_RS03825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SP5448_RS03830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SP5448_RS03835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SP5448_RS03855	COG0726	polysaccharide deacetylase
SP5448_RS03860	COG0513	Belongs to the DEAD box helicase family
SP5448_RS03880	COG1956	GAF domain-containing protein
SP5448_RS03885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SP5448_RS03890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SP5448_RS03890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SP5448_RS03920	COG4109	DRTGG domain
SP5448_RS03970	COG2814	Major facilitator Superfamily
SP5448_RS03980	COG1187	pseudouridine synthase activity
SP5448_RS03985	COG2801	Transposase and inactivated derivatives
SP5448_RS04010	COG2723	6-phospho-beta-galactosidase activity
SP5448_RS04020	COG3711	transcriptional antiterminator
SP5448_RS04020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP5448_RS04030	COG1447	Phosphotransferase system cellobiose-specific component IIA
SP5448_RS04040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP5448_RS04045	COG1126	abc transporter atp-binding protein
SP5448_RS04050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP5448_RS04070	COG1696	Membrane protein involved in D-alanine export
SP5448_RS04080	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SP5448_RS04085	COG0657	acetylesterase activity
SP5448_RS04095	COG2182	Extracellular solute-binding protein
SP5448_RS04100	COG0366	Alpha amylase catalytic
SP5448_RS04110	COG1175	transmembrane transport
SP5448_RS04115	COG3833	ABC-type maltose transport systems, permease component
SP5448_RS04130	COG3833	ABC-type maltose transport systems, permease component
SP5448_RS04135	COG1175	transmembrane transport
SP5448_RS04140	COG2182	Extracellular solute-binding protein
SP5448_RS04145	COG1609	Transcriptional regulator
SP5448_RS04150	COG1640	4-alpha-glucanotransferase
SP5448_RS04155	COG0058	SHG alpha-glucan phosphorylase activity
SP5448_RS04195	COG1396	sequence-specific DNA binding
SP5448_RS04300	COG1783	phage Terminase large subunit
SP5448_RS04455	COG1131	(ABC) transporter
SP5448_RS04460	COG1725	Transcriptional regulator
SP5448_RS04475	COG0469	pyruvate kinase activity
SP5448_RS04490	COG2824	Alkylphosphonate utilization operon protein PhnA
SP5448_RS04495	COG0765	amino acid transport
SP5448_RS04500	COG1126	abc transporter atp-binding protein
SP5448_RS04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP5448_RS04515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SP5448_RS04520	COG1115	amino acid carrier protein
SP5448_RS04570	COG4591	ABC-type transport system involved in lipoprotein release permease component
SP5448_RS04570	COG1136	(ABC) transporter
SP5448_RS04600	COG0196	riboflavin kinase activity
SP5448_RS04615	COG0483	inositol monophosphate 1-phosphatase activity
SP5448_RS04620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SP5448_RS04620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SP5448_RS04630	COG0573	inorganic phosphate transmembrane transporter activity
SP5448_RS04635	COG0581	inorganic phosphate transmembrane transporter activity
SP5448_RS04650	COG0704	Plays a role in the regulation of phosphate uptake
SP5448_RS04660	COG0745	RESPONSE REGULATOR receiver
SP5448_RS04665	COG5002	protein histidine kinase activity
SP5448_RS04680	COG2813	Specifically methylates the guanine in position
SP5448_RS04685	COG0295	cytidine deaminase activity
SP5448_RS04690	COG1744	ABC transporter substrate-binding protein PnrA-like
SP5448_RS04695	COG3845	ABC transporter
SP5448_RS04700	COG4603	Belongs to the binding-protein-dependent transport system permease family
SP5448_RS04705	COG1079	Belongs to the binding-protein-dependent transport system permease family
SP5448_RS04710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SP5448_RS04715	COG4684	Psort location CytoplasmicMembrane, score
SP5448_RS04720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SP5448_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SP5448_RS04770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SP5448_RS04775	COG1328	CTP reductase activity
SP5448_RS04775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SP5448_RS04780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SP5448_RS04785	COG0352	thiamine-phosphate diphosphorylase activity
SP5448_RS04785	COG0351	phosphomethylpyrimidine kinase
SP5448_RS04795	COG0488	(ABC) transporter
SP5448_RS04815	COG2188	Transcriptional regulator
SP5448_RS04825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SP5448_RS04845	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SP5448_RS04880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SP5448_RS04885	COG0511	ligase activity, forming carbon-carbon bonds
SP5448_RS04895	COG2851	Citrate transporter
SP5448_RS04910	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SP5448_RS04915	COG0511	ligase activity, forming carbon-carbon bonds
SP5448_RS04960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SP5448_RS04965	COG0758	DNA mediated transformation
SP5448_RS04985	COG1272	protein, Hemolysin III
SP5448_RS05000	COG0346	lactoylglutathione lyase activity
SP5448_RS05005	COG3764	Sortase (surface protein transpeptidase)
SP5448_RS05025	COG1132	(ABC) transporter
SP5448_RS05030	COG1132	(ABC) transporter
SP5448_RS05060	COG2890	protein-(glutamine-N5) methyltransferase activity
SP5448_RS05085	COG2233	PERMEase
SP5448_RS05100	COG1174	glycine betaine transport
SP5448_RS05120	COG0280	phosphate acetyltransferase
SP5448_RS05125	COG0564	pseudouridine synthase activity
SP5448_RS05135	COG2357	RelA SpoT domain protein
SP5448_RS05150	COG1104	cysteine desulfurase activity
SP5448_RS05165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SP5448_RS05175	COG0628	permease
SP5448_RS05185	COG0038	chloride channel
SP5448_RS05190	COG3700	Belongs to the class B bacterial acid phosphatase family
SP5448_RS05205	COG3493	citrate carrier protein
SP5448_RS05210	COG3290	protein histidine kinase activity
SP5448_RS05215	COG4565	transcriptional regulatory protein
SP5448_RS05225	COG1177	transmembrane transport
SP5448_RS05230	COG1176	ABC-type spermidine putrescine transport system, permease component I
SP5448_RS05245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SP5448_RS05265	COG0285	dihydrofolate synthase activity
SP5448_RS05305	COG1396	sequence-specific DNA binding
SP5448_RS05320	COG1131	(ABC) transporter
SP5448_RS05380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SP5448_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
SP5448_RS05400	COG1011	Hydrolase
SP5448_RS05415	COG1840	ABC-type Fe3 transport system, periplasmic component
SP5448_RS05420	COG4753	response regulator
SP5448_RS05420	COG2207	Transcriptional regulator
SP5448_RS05425	COG2972	Histidine kinase
SP5448_RS05430	COG3716	PTS system mannose fructose sorbose family IID component
SP5448_RS05435	COG3715	PTS system
SP5448_RS05470	COG0105	UTP biosynthetic process
SP5448_RS05485	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SP5448_RS05490	COG1518	maintenance of DNA repeat elements
SP5448_RS05505	COG0647	UMP catabolic process
SP5448_RS05515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SP5448_RS05535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SP5448_RS05540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SP5448_RS05545	COG3442	glutamine amidotransferase
SP5448_RS05550	COG0095	Lipoate-protein ligase
SP5448_RS05555	COG5492	domain, Protein
SP5448_RS05575	COG0022	dehydrogenase e1 component
SP5448_RS05575	COG0508	dehydrogenase complex catalyzes the overall conversion of
SP5448_RS05580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SP5448_RS05585	COG0488	(ABC) transporter
SP5448_RS05605	COG1129	ABC transporter
SP5448_RS05625	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SP5448_RS05630	COG0457	Tetratricopeptide repeat
SP5448_RS05635	COG0628	permease
SP5448_RS05640	COG1051	belongs to the nudix hydrolase family
SP5448_RS05645	COG1088	dTDP-glucose 4,6-dehydratase activity
SP5448_RS05655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SP5448_RS05660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SP5448_RS05670	COG2384	SAM-dependent methyltransferase
SP5448_RS05675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SP5448_RS05690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SP5448_RS05690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SP5448_RS05695	COG0300	oxidoreductase activity
SP5448_RS05705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SP5448_RS05710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SP5448_RS05745	COG0539	negative regulation of cytoplasmic translation
SP5448_RS05765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SP5448_RS05775	COG0187	DNA topoisomerase II activity
SP5448_RS05795	COG0765	amino acid transport
SP5448_RS05800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP5448_RS05825	COG0583	DNA-binding transcription factor activity
SP5448_RS05885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SP5448_RS05895	COG3425	synthase
SP5448_RS05930	COG0745	RESPONSE REGULATOR receiver
SP5448_RS05935	COG2357	RelA SpoT domain protein
SP5448_RS05940	COG0737	Belongs to the 5'-nucleotidase family
SP5448_RS05945	COG0242	peptide deformylase activity
SP5448_RS05955	COG0488	(ABC) transporter
SP5448_RS05975	COG0105	UTP biosynthetic process
SP5448_RS05990	COG2801	Transposase and inactivated derivatives
SP5448_RS05995	COG1705	Flagellar rod assembly protein muramidase FlgJ
SP5448_RS05995	COG1388	LysM domain
SP5448_RS06000	COG1388	LysM domain
SP5448_RS06000	COG1705	Flagellar rod assembly protein muramidase FlgJ
SP5448_RS06005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SP5448_RS06005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP5448_RS06005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SP5448_RS06010	COG1105	Belongs to the carbohydrate kinase PfkB family
SP5448_RS06015	COG1349	DNA-binding transcription factor activity
SP5448_RS06065	COG1837	Belongs to the UPF0109 family
SP5448_RS06075	COG0584	glycerophosphoryl diester phosphodiesterase
SP5448_RS06080	COG0577	efflux transmembrane transporter activity
SP5448_RS06085	COG1136	(ABC) transporter
SP5448_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SP5448_RS06120	COG0564	pseudouridine synthase activity
SP5448_RS06130	COG0583	DNA-binding transcription factor activity
SP5448_RS06135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SP5448_RS06160	COG1104	cysteine desulfurase activity
SP5448_RS06170	COG0285	dihydrofolate synthase activity
SP5448_RS06175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SP5448_RS06195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SP5448_RS06200	COG1368	sulfuric ester hydrolase activity
SP5448_RS06255	COG1216	Glycosyl transferase, family 2
SP5448_RS06300	COG2151	metal-sulfur cluster biosynthetic enzyme
SP5448_RS06305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SP5448_RS06310	COG0358	DNA primase activity
SP5448_RS06315	COG1970	mechanosensitive ion channel activity
SP5448_RS06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP5448_RS06340	COG2321	neutral zinc metallopeptidase
SP5448_RS06350	COG0577	efflux transmembrane transporter activity
SP5448_RS06435	COG1597	lipid kinase activity
SP5448_RS06445	COG4708	membrane
SP5448_RS06465	COG1131	(ABC) transporter
SP5448_RS06555	COG0038	chloride channel
SP5448_RS06565	COG0716	FMN binding
SP5448_RS06570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SP5448_RS06580	COG2222	sugar isomerase
SP5448_RS06585	COG2188	Transcriptional regulator
SP5448_RS06620	COG0436	Aminotransferase
SP5448_RS06625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SP5448_RS06625	COG1199	ATP-dependent helicase activity
SP5448_RS06640	COG2177	Part of the ABC transporter FtsEX involved in
SP5448_RS06645	COG2884	Cell division ATP-binding protein ftsE
SP5448_RS06655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SP5448_RS06660	COG0546	phosphoglycolate phosphatase activity
SP5448_RS06665	COG0800	Aldolase
SP5448_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
SP5448_RS06695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP5448_RS06700	COG3715	PTS system
SP5448_RS06705	COG3716	PTS system mannose fructose sorbose family IID component
SP5448_RS06715	COG1609	Transcriptional regulator
SP5448_RS06730	COG1078	dGTPase activity
SP5448_RS06765	COG0772	Belongs to the SEDS family
SP5448_RS06775	COG1164	Oligoendopeptidase f
SP5448_RS06780	COG0386	Belongs to the glutathione peroxidase family
SP5448_RS06830	COG4443	Transcriptional Coactivator p15 (PC4)
SP5448_RS06835	COG0826	peptidase U32
SP5448_RS06880	COG2183	response to ionizing radiation
SP5448_RS06890	COG0701	Predicted permease
SP5448_RS06895	COG3689	TIGRFAM TIGR03943 family protein
SP5448_RS06905	COG1263	PTS System
SP5448_RS06905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP5448_RS06905	COG2190	(PTS) system
SP5448_RS06910	COG3711	transcriptional antiterminator
SP5448_RS06915	COG0477	Major facilitator Superfamily
SP5448_RS06920	COG0552	protein localization to endoplasmic reticulum
SP5448_RS06930	COG0561	phosphatase activity
SP5448_RS06980	COG4695	Portal protein
SP5448_RS07060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SP5448_RS07070	COG1196	nuclear chromosome segregation
SP5448_RS07080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SP5448_RS07085	COG5002	protein histidine kinase activity
SP5448_RS07090	COG0745	RESPONSE REGULATOR receiver
SP5448_RS07105	COG0183	Belongs to the thiolase family
SP5448_RS07125	COG4555	ABC transporter
SP5448_RS07135	COG0438	transferase activity, transferring glycosyl groups
SP5448_RS07145	COG1609	Transcriptional regulator
SP5448_RS07150	COG0006	proline dipeptidase activity
SP5448_RS07155	COG0778	Nitroreductase
SP5448_RS07165	COG0463	Glycosyl transferase, family 2
SP5448_RS07195	COG0557	exoribonuclease II activity
SP5448_RS07205	COG2814	Major facilitator Superfamily
SP5448_RS07210	COG0433	COG0433 Predicted ATPase
SP5448_RS07290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SP5448_RS07300	COG1573	uracil-dna glycosylase
SP5448_RS07305	COG1702	phosphate starvation-inducible protein PhoH
SP5448_RS07395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SP5448_RS07405	COG0494	nUDIX hydrolase
SP5448_RS07420	COG0673	inositol 2-dehydrogenase activity
SP5448_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
SP5448_RS07505	COG1304	FMN binding
SP5448_RS07515	COG0708	Exodeoxyribonuclease III
SP5448_RS07520	COG1393	Belongs to the ArsC family
SP5448_RS07550	COG0470	DNA polymerase III
SP5448_RS07575	COG2244	polysaccharide biosynthetic process
SP5448_RS07585	COG1120	ATPase activity
SP5448_RS07590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SP5448_RS07595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SP5448_RS07600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SP5448_RS07615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SP5448_RS07620	COG1253	flavin adenine dinucleotide binding
SP5448_RS07625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SP5448_RS07630	COG1242	4 iron, 4 sulfur cluster binding
SP5448_RS07635	COG0671	phosphoesterase, PA-phosphatase related
SP5448_RS07640	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SP5448_RS07655	COG1187	pseudouridine synthase activity
SP5448_RS07710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SP5448_RS07715	COG5433	transposase activity
SP5448_RS07730	COG1254	Belongs to the acylphosphatase family
SP5448_RS07745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SP5448_RS07765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SP5448_RS07775	COG1484	DNA-dependent DNA replication
SP5448_RS07795	COG0745	RESPONSE REGULATOR receiver
SP5448_RS07810	COG1704	LemA family
SP5448_RS07820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SP5448_RS07825	COG0569	domain protein
SP5448_RS07835	COG1114	Component of the transport system for branched-chain amino acids
SP5448_RS07850	COG1464	Belongs to the NlpA lipoprotein family
SP5448_RS07855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SP5448_RS07870	COG2226	methyltransferase
SP5448_RS07875	COG0799	negative regulation of ribosome biogenesis
SP5448_RS07880	COG1713	HD superfamily hydrolase involved in NAD metabolism
SP5448_RS07890	COG1534	Rna-binding protein
SP5448_RS07895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SP5448_RS07900	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SP5448_RS07915	COG5433	transposase activity
SP5448_RS07955	COG1929	Belongs to the glycerate kinase type-1 family
SP5448_RS07960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SP5448_RS07990	COG0577	efflux transmembrane transporter activity
SP5448_RS07995	COG1136	(ABC) transporter
SP5448_RS08020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP5448_RS08020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP5448_RS08025	COG1447	Phosphotransferase system cellobiose-specific component IIA
SP5448_RS08075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SP5448_RS08080	COG1476	TRANSCRIPTIONal
SP5448_RS08100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SP5448_RS08110	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SP5448_RS08125	COG1045	serine acetyltransferase
SP5448_RS08140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SP5448_RS08145	COG3037	sugar-specific permease SgaT UlaA
SP5448_RS08155	COG3711	transcriptional antiterminator
SP5448_RS08180	COG1846	Transcriptional regulator
SP5448_RS08200	COG4589	Belongs to the CDS family
SP5448_RS08210	COG1862	Preprotein translocase
SP5448_RS08220	COG1523	belongs to the glycosyl hydrolase 13 family
SP5448_RS08230	COG3842	ATPase activity
SP5448_RS08270	COG2190	(PTS) system
SP5448_RS08270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP5448_RS08270	COG1263	PTS System
SP5448_RS08275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SP5448_RS08290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SP5448_RS08295	COG0512	Glutamine amidotransferase of anthranilate synthase
SP5448_RS08300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SP5448_RS08335	COG0601	transmembrane transport
SP5448_RS08345	COG1122	ATPase activity
SP5448_RS08365	COG0803	Belongs to the bacterial solute-binding protein 9 family
SP5448_RS08380	COG5433	transposase activity
SP5448_RS08410	COG3711	transcriptional antiterminator
SP5448_RS08420	COG3942	CHAP domain
SP5448_RS08420	COG1705	Flagellar rod assembly protein muramidase FlgJ
SP5448_RS08425	COG2205	protein histidine kinase activity
SP5448_RS08430	COG0745	RESPONSE REGULATOR receiver
SP5448_RS08435	COG0577	efflux transmembrane transporter activity
SP5448_RS08440	COG1136	(ABC) transporter
SP5448_RS08490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SP5448_RS08505	COG1882	Formate acetyltransferase
SP5448_RS08510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP5448_RS08515	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SP5448_RS08520	COG1447	Phosphotransferase system cellobiose-specific component IIA
SP5448_RS08525	COG2390	Transcriptional regulator
SP5448_RS08530	COG1349	DNA-binding transcription factor activity
SP5448_RS08535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SP5448_RS08550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SP5448_RS08565	COG0564	pseudouridine synthase activity
SP5448_RS08595	COG0542	response to heat
SP5448_RS08600	COG4463	regulation of RNA biosynthetic process
SP5448_RS08615	COG0450	alkyl hydroperoxide reductase
SP5448_RS08630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SP5448_RS08640	COG3404	Formiminotransferase-cyclodeaminase
SP5448_RS08655	COG0531	amino acid
SP5448_RS08685	COG3590	peptidase
SP5448_RS08690	COG0366	Alpha amylase catalytic
SP5448_RS08695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SP5448_RS08695	COG1263	PTS System
SP5448_RS08700	COG2188	Transcriptional regulator
SP5448_RS08710	COG2514	catechol 2,3-dioxygenase activity
SP5448_RS08720	COG0602	queuosine metabolic process
SP5448_RS08735	COG1328	CTP reductase activity
SP5448_RS08760	COG1393	Belongs to the ArsC family
SP5448_RS08775	COG0519	Catalyzes the synthesis of GMP from XMP
SP5448_RS08785	COG2814	Major facilitator Superfamily
SP5448_RS08820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SP5448_RS08825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SP5448_RS08830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SP5448_RS08910	COG1511	domain protein
SP5448_RS08930	COG5433	transposase activity
SP5448_RS08940	COG0305	Participates in initiation and elongation during chromosome replication
SP5448_RS08970	COG1760	l-serine dehydratase
SP5448_RS08975	COG1760	l-serine dehydratase
SP5448_RS08980	COG0741	lytic transglycosylase activity
SP5448_RS08985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SP5448_RS09000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SP5448_RS09010	COG0612	Peptidase, M16
SP5448_RS09020	COG1215	transferase activity, transferring glycosyl groups
SP5448_RS09050	COG0517	IMP dehydrogenase activity
SP5448_RS09050	COG0516	GMP reductase activity
SP5448_RS09060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SP5448_RS09065	COG0488	(ABC) transporter
SP5448_RS09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SP5448_RS09110	COG1475	DNA binding