locus-tag	class	description
G8B42_RS00010	COG0592	DNA-directed DNA polymerase activity
G8B42_RS00020	COG0012	GTP binding
G8B42_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8B42_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8B42_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8B42_RS00065	COG0531	amino acid
G8B42_RS00245	COG3942	CHAP domain
G8B42_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8B42_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8B42_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8B42_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G8B42_RS00330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8B42_RS00350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8B42_RS00365	COG1454	alcohol dehydrogenase
G8B42_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
G8B42_RS00370	COG1064	alcohol dehydrogenase
G8B42_RS00375	COG0534	Mate efflux family protein
G8B42_RS00485	COG0201	protein transport
G8B42_RS00635	COG1121	(ABC) transporter
G8B42_RS00640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8B42_RS00655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8B42_RS00655	COG4499	WXG100 protein secretion system (Wss), protein YukC
G8B42_RS00675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8B42_RS00680	COG1459	type II secretion system
G8B42_RS00685	COG4537	Required for transformation and DNA binding
G8B42_RS00730	COG1363	Peptidase, m42
G8B42_RS00740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8B42_RS00745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8B42_RS00755	COG1428	Deoxynucleoside kinase
G8B42_RS00760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8B42_RS00820	COG2031	fatty acid transporter
G8B42_RS00835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8B42_RS00850	COG0251	oxidation-reduction process
G8B42_RS00865	COG1269	ATP hydrolysis coupled proton transport
G8B42_RS00870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8B42_RS00880	COG1527	subunit (C
G8B42_RS00885	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
G8B42_RS00920	COG1744	ABC transporter substrate-binding protein PnrA-like
G8B42_RS00965	COG0626	cystathionine gamma-synthase activity
G8B42_RS00995	COG3623	hexulose-6-phosphate isomerase
G8B42_RS01015	COG4175	Glycine betaine
G8B42_RS01015	COG3448	diguanylate cyclase activity
G8B42_RS01025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8B42_RS01025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8B42_RS01055	COG1268	BioY protein
G8B42_RS01060	COG1234	tRNA 3'-trailer cleavage
G8B42_RS01100	COG0457	Tetratricopeptide repeat
G8B42_RS01100	COG0705	Rhomboid family
G8B42_RS01120	COG1132	(ABC) transporter
G8B42_RS01125	COG1132	(ABC) transporter
G8B42_RS01135	COG0756	dUTP diphosphatase activity
G8B42_RS01160	COG3290	protein histidine kinase activity
G8B42_RS01185	COG1847	R3H domain protein
G8B42_RS01205	COG1175	transmembrane transport
G8B42_RS01210	COG0395	ABC-type sugar transport system, permease component
G8B42_RS01225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8B42_RS01240	COG0084	hydrolase, TatD family'
G8B42_RS01265	COG1564	THIamine pyrophosphokinase
G8B42_RS01280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8B42_RS01320	COG0765	amino acid transport
G8B42_RS01340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8B42_RS01350	COG0719	Fe-S assembly protein
G8B42_RS01355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8B42_RS01370	COG1686	Belongs to the peptidase S11 family
G8B42_RS01375	COG1686	Belongs to the peptidase S11 family
G8B42_RS01380	COG4166	transmembrane transport
G8B42_RS01385	COG0601	transmembrane transport
G8B42_RS01390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8B42_RS01395	COG0444	Belongs to the ABC transporter superfamily
G8B42_RS01445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G8B42_RS01450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G8B42_RS01455	COG1534	Rna-binding protein
G8B42_RS01465	COG1713	HD superfamily hydrolase involved in NAD metabolism
G8B42_RS01470	COG1335	isochorismatase
G8B42_RS01475	COG0799	negative regulation of ribosome biogenesis
G8B42_RS01480	COG2226	methyltransferase
G8B42_RS01495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B42_RS01500	COG1464	Belongs to the NlpA lipoprotein family
G8B42_RS01515	COG1114	Component of the transport system for branched-chain amino acids
G8B42_RS01525	COG0569	domain protein
G8B42_RS01530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8B42_RS01540	COG1704	LemA family
G8B42_RS01555	COG0745	RESPONSE REGULATOR receiver
G8B42_RS01575	COG1484	DNA-dependent DNA replication
G8B42_RS01585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G8B42_RS01605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8B42_RS01620	COG1254	Belongs to the acylphosphatase family
G8B42_RS01625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8B42_RS01680	COG1187	pseudouridine synthase activity
G8B42_RS01695	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G8B42_RS01700	COG0671	phosphoesterase, PA-phosphatase related
G8B42_RS01705	COG1242	4 iron, 4 sulfur cluster binding
G8B42_RS01710	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G8B42_RS01715	COG1253	flavin adenine dinucleotide binding
G8B42_RS01720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G8B42_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8B42_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8B42_RS01745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G8B42_RS01750	COG1120	ATPase activity
G8B42_RS01765	COG2244	polysaccharide biosynthetic process
G8B42_RS01790	COG0470	DNA polymerase III
G8B42_RS01820	COG1393	Belongs to the ArsC family
G8B42_RS01825	COG0708	Exodeoxyribonuclease III
G8B42_RS01830	COG1304	FMN binding
G8B42_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
G8B42_RS01910	COG0673	inositol 2-dehydrogenase activity
G8B42_RS01925	COG0494	nUDIX hydrolase
G8B42_RS01935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8B42_RS02030	COG1573	uracil-dna glycosylase
G8B42_RS02040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G8B42_RS02140	COG2274	protein secretion by the type I secretion system
G8B42_RS02220	COG0433	COG0433 Predicted ATPase
G8B42_RS02225	COG2814	Major facilitator Superfamily
G8B42_RS02240	COG0557	exoribonuclease II activity
G8B42_RS02270	COG0463	Glycosyl transferase, family 2
G8B42_RS02280	COG0778	Nitroreductase
G8B42_RS02285	COG0006	proline dipeptidase activity
G8B42_RS02290	COG1609	Transcriptional regulator
G8B42_RS02300	COG0438	transferase activity, transferring glycosyl groups
G8B42_RS02310	COG4555	ABC transporter
G8B42_RS02325	COG2376	Dihydroxyacetone kinase
G8B42_RS02335	COG2376	Dihydroxyacetone kinase
G8B42_RS02340	COG1461	Dihydroxyacetone kinase
G8B42_RS02345	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
G8B42_RS02350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8B42_RS02360	COG0183	Belongs to the thiolase family
G8B42_RS02375	COG0745	RESPONSE REGULATOR receiver
G8B42_RS02380	COG5002	protein histidine kinase activity
G8B42_RS02385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G8B42_RS02395	COG1196	nuclear chromosome segregation
G8B42_RS02410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8B42_RS02525	COG1619	proteins homologs of microcin C7 resistance protein MccF
G8B42_RS02535	COG0561	phosphatase activity
G8B42_RS02540	COG0561	phosphatase activity
G8B42_RS02545	COG0552	protein localization to endoplasmic reticulum
G8B42_RS02550	COG0477	Major facilitator Superfamily
G8B42_RS02555	COG3711	transcriptional antiterminator
G8B42_RS02560	COG2190	(PTS) system
G8B42_RS02560	COG1263	PTS System
G8B42_RS02560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B42_RS02570	COG3689	TIGRFAM TIGR03943 family protein
G8B42_RS02575	COG0701	Predicted permease
G8B42_RS02585	COG2183	response to ionizing radiation
G8B42_RS02630	COG0826	peptidase U32
G8B42_RS02635	COG4443	Transcriptional Coactivator p15 (PC4)
G8B42_RS02685	COG0386	Belongs to the glutathione peroxidase family
G8B42_RS02690	COG1164	Oligoendopeptidase f
G8B42_RS02700	COG0772	Belongs to the SEDS family
G8B42_RS02730	COG1078	dGTPase activity
G8B42_RS02745	COG1609	Transcriptional regulator
G8B42_RS02755	COG3716	PTS system mannose fructose sorbose family IID component
G8B42_RS02760	COG3715	PTS system
G8B42_RS02765	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B42_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
G8B42_RS02795	COG0800	Aldolase
G8B42_RS02800	COG0546	phosphoglycolate phosphatase activity
G8B42_RS02810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G8B42_RS02820	COG2884	Cell division ATP-binding protein ftsE
G8B42_RS02825	COG2177	Part of the ABC transporter FtsEX involved in
G8B42_RS02840	COG1199	ATP-dependent helicase activity
G8B42_RS02840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8B42_RS02845	COG0436	Aminotransferase
G8B42_RS02935	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B42_RS02965	COG2188	Transcriptional regulator
G8B42_RS02970	COG2222	sugar isomerase
G8B42_RS02980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G8B42_RS02985	COG0716	FMN binding
G8B42_RS02995	COG0038	chloride channel
G8B42_RS03010	COG0582	viral genome integration into host DNA
G8B42_RS03140	COG1475	DNA binding
G8B42_RS03285	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B42_RS03370	COG1131	(ABC) transporter
G8B42_RS03390	COG4708	membrane
G8B42_RS03400	COG1597	lipid kinase activity
G8B42_RS03485	COG0577	efflux transmembrane transporter activity
G8B42_RS03490	COG1136	(ABC) transporter
G8B42_RS03495	COG2321	neutral zinc metallopeptidase
G8B42_RS03510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B42_RS03520	COG1970	mechanosensitive ion channel activity
G8B42_RS03530	COG0358	DNA primase activity
G8B42_RS03535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8B42_RS03540	COG2151	metal-sulfur cluster biosynthetic enzyme
G8B42_RS03585	COG1216	Glycosyl transferase, family 2
G8B42_RS03645	COG1368	sulfuric ester hydrolase activity
G8B42_RS03650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G8B42_RS03670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8B42_RS03675	COG0285	dihydrofolate synthase activity
G8B42_RS03685	COG1104	cysteine desulfurase activity
G8B42_RS03715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G8B42_RS03720	COG0583	DNA-binding transcription factor activity
G8B42_RS03730	COG0564	pseudouridine synthase activity
G8B42_RS03760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8B42_RS03765	COG1136	(ABC) transporter
G8B42_RS03770	COG0577	efflux transmembrane transporter activity
G8B42_RS03775	COG0584	glycerophosphoryl diester phosphodiesterase
G8B42_RS03785	COG1837	Belongs to the UPF0109 family
G8B42_RS03840	COG1349	DNA-binding transcription factor activity
G8B42_RS03845	COG1105	Belongs to the carbohydrate kinase PfkB family
G8B42_RS03850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8B42_RS03850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8B42_RS03850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8B42_RS03855	COG1388	LysM domain
G8B42_RS03855	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B42_RS03860	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B42_RS03860	COG1388	LysM domain
G8B42_RS03880	COG0105	UTP biosynthetic process
G8B42_RS03900	COG0488	(ABC) transporter
G8B42_RS03905	COG0242	peptide deformylase activity
G8B42_RS03910	COG0737	Belongs to the 5'-nucleotidase family
G8B42_RS03915	COG2357	RelA SpoT domain protein
G8B42_RS03920	COG0745	RESPONSE REGULATOR receiver
G8B42_RS03955	COG3425	synthase
G8B42_RS03965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G8B42_RS04020	COG0583	DNA-binding transcription factor activity
G8B42_RS04045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B42_RS04050	COG0765	amino acid transport
G8B42_RS04070	COG0187	DNA topoisomerase II activity
G8B42_RS04080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8B42_RS04105	COG0539	negative regulation of cytoplasmic translation
G8B42_RS04150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8B42_RS04155	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G8B42_RS04165	COG0300	oxidoreductase activity
G8B42_RS04170	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G8B42_RS04170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8B42_RS04185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8B42_RS04190	COG2384	SAM-dependent methyltransferase
G8B42_RS04200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8B42_RS04205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G8B42_RS04215	COG1088	dTDP-glucose 4,6-dehydratase activity
G8B42_RS04220	COG0582	viral genome integration into host DNA
G8B42_RS04355	COG1051	belongs to the nudix hydrolase family
G8B42_RS04360	COG0628	permease
G8B42_RS04365	COG0457	Tetratricopeptide repeat
G8B42_RS04370	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G8B42_RS04385	COG1129	ABC transporter
G8B42_RS04405	COG0488	(ABC) transporter
G8B42_RS04410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G8B42_RS04415	COG0022	dehydrogenase e1 component
G8B42_RS04415	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8B42_RS04420	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8B42_RS04430	COG5492	domain, Protein
G8B42_RS04435	COG0095	Lipoate-protein ligase
G8B42_RS04440	COG3442	glutamine amidotransferase
G8B42_RS04445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8B42_RS04450	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G8B42_RS04470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8B42_RS04480	COG0647	UMP catabolic process
G8B42_RS04495	COG1518	maintenance of DNA repeat elements
G8B42_RS04500	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G8B42_RS04545	COG3715	PTS system
G8B42_RS04550	COG3716	PTS system mannose fructose sorbose family IID component
G8B42_RS04555	COG2972	Histidine kinase
G8B42_RS04560	COG2207	Transcriptional regulator
G8B42_RS04560	COG4753	response regulator
G8B42_RS04570	COG1012	belongs to the aldehyde dehydrogenase family
G8B42_RS04585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8B42_RS04660	COG1131	(ABC) transporter
G8B42_RS04675	COG1396	sequence-specific DNA binding
G8B42_RS04705	COG0285	dihydrofolate synthase activity
G8B42_RS04725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8B42_RS04740	COG1176	ABC-type spermidine putrescine transport system, permease component I
G8B42_RS04745	COG1177	transmembrane transport
G8B42_RS04755	COG4565	transcriptional regulatory protein
G8B42_RS04760	COG3290	protein histidine kinase activity
G8B42_RS04765	COG3493	citrate carrier protein
G8B42_RS04780	COG3700	Belongs to the class B bacterial acid phosphatase family
G8B42_RS04785	COG0038	chloride channel
G8B42_RS04795	COG0628	permease
G8B42_RS04805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G8B42_RS04820	COG1104	cysteine desulfurase activity
G8B42_RS04835	COG2357	RelA SpoT domain protein
G8B42_RS04845	COG0564	pseudouridine synthase activity
G8B42_RS04850	COG0280	phosphate acetyltransferase
G8B42_RS04855	COG4221	oxidoreductase activity
G8B42_RS04870	COG1174	glycine betaine transport
G8B42_RS04885	COG2233	PERMEase
G8B42_RS04910	COG2890	protein-(glutamine-N5) methyltransferase activity
G8B42_RS04940	COG1132	(ABC) transporter
G8B42_RS04945	COG1132	(ABC) transporter
G8B42_RS04965	COG3764	Sortase (surface protein transpeptidase)
G8B42_RS04970	COG0346	lactoylglutathione lyase activity
G8B42_RS04985	COG1272	protein, Hemolysin III
G8B42_RS05005	COG0758	DNA mediated transformation
G8B42_RS05010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8B42_RS05055	COG0511	ligase activity, forming carbon-carbon bonds
G8B42_RS05060	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
G8B42_RS05075	COG2851	Citrate transporter
G8B42_RS05085	COG0511	ligase activity, forming carbon-carbon bonds
G8B42_RS05090	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
G8B42_RS05120	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
G8B42_RS05140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8B42_RS05150	COG2188	Transcriptional regulator
G8B42_RS05170	COG0488	(ABC) transporter
G8B42_RS05180	COG0351	phosphomethylpyrimidine kinase
G8B42_RS05180	COG0352	thiamine-phosphate diphosphorylase activity
G8B42_RS05185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8B42_RS05190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8B42_RS05190	COG1328	CTP reductase activity
G8B42_RS05195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8B42_RS05225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8B42_RS05235	COG0095	Lipoate-protein ligase
G8B42_RS05245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8B42_RS05250	COG4684	Psort location CytoplasmicMembrane, score
G8B42_RS05255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8B42_RS05260	COG1079	Belongs to the binding-protein-dependent transport system permease family
G8B42_RS05265	COG4603	Belongs to the binding-protein-dependent transport system permease family
G8B42_RS05270	COG3845	ABC transporter
G8B42_RS05275	COG1744	ABC transporter substrate-binding protein PnrA-like
G8B42_RS05280	COG0295	cytidine deaminase activity
G8B42_RS05285	COG2813	Specifically methylates the guanine in position
G8B42_RS05300	COG5002	protein histidine kinase activity
G8B42_RS05305	COG0745	RESPONSE REGULATOR receiver
G8B42_RS05315	COG0704	Plays a role in the regulation of phosphate uptake
G8B42_RS05330	COG0581	inorganic phosphate transmembrane transporter activity
G8B42_RS05335	COG0573	inorganic phosphate transmembrane transporter activity
G8B42_RS05345	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
G8B42_RS05345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8B42_RS05350	COG0483	inositol monophosphate 1-phosphatase activity
G8B42_RS05365	COG0196	riboflavin kinase activity
G8B42_RS05395	COG1136	(ABC) transporter
G8B42_RS05395	COG4591	ABC-type transport system involved in lipoprotein release permease component
G8B42_RS05445	COG1115	amino acid carrier protein
G8B42_RS05450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G8B42_RS05460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B42_RS05465	COG1126	abc transporter atp-binding protein
G8B42_RS05470	COG0765	amino acid transport
G8B42_RS05475	COG2824	Alkylphosphonate utilization operon protein PhnA
G8B42_RS05490	COG0469	pyruvate kinase activity
G8B42_RS05505	COG1725	Transcriptional regulator
G8B42_RS05510	COG1131	(ABC) transporter
G8B42_RS05535	COG0058	SHG alpha-glucan phosphorylase activity
G8B42_RS05540	COG1640	4-alpha-glucanotransferase
G8B42_RS05545	COG1609	Transcriptional regulator
G8B42_RS05550	COG2182	Extracellular solute-binding protein
G8B42_RS05555	COG1175	transmembrane transport
G8B42_RS05560	COG3833	ABC-type maltose transport systems, permease component
G8B42_RS05575	COG3833	ABC-type maltose transport systems, permease component
G8B42_RS05580	COG1175	transmembrane transport
G8B42_RS05590	COG0366	Alpha amylase catalytic
G8B42_RS05595	COG2182	Extracellular solute-binding protein
G8B42_RS05600	COG0657	acetylesterase activity
G8B42_RS05605	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G8B42_RS05615	COG1696	Membrane protein involved in D-alanine export
G8B42_RS05635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B42_RS05640	COG1126	abc transporter atp-binding protein
G8B42_RS05650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B42_RS05660	COG1447	Phosphotransferase system cellobiose-specific component IIA
G8B42_RS05670	COG3711	transcriptional antiterminator
G8B42_RS05670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8B42_RS05680	COG2723	6-phospho-beta-galactosidase activity
G8B42_RS05710	COG0157	Belongs to the NadC ModD family
G8B42_RS05735	COG1187	pseudouridine synthase activity
G8B42_RS05745	COG2814	Major facilitator Superfamily
G8B42_RS05795	COG4109	DRTGG domain
G8B42_RS05800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8B42_RS05825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G8B42_RS05825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G8B42_RS05835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8B42_RS05840	COG1956	GAF domain-containing protein
G8B42_RS05860	COG0513	Belongs to the DEAD box helicase family
G8B42_RS05870	COG0726	polysaccharide deacetylase
G8B42_RS05890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8B42_RS05895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8B42_RS05930	COG1476	TRANSCRIPTIONal
G8B42_RS05945	COG4122	O-methyltransferase activity
G8B42_RS05950	COG2223	nitrite transmembrane transporter activity
G8B42_RS05965	COG1187	pseudouridine synthase activity
G8B42_RS06010	COG0658	competence protein
G8B42_RS06010	COG2333	competence protein COMEC
G8B42_RS06015	COG1596	polysaccharide export
G8B42_RS06015	COG1555	photosystem II stabilization
G8B42_RS06020	COG0204	Acyl-transferase
G8B42_RS06025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G8B42_RS06040	COG0513	Belongs to the DEAD box helicase family
G8B42_RS06055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8B42_RS06070	COG2116	formate transmembrane transporter activity
G8B42_RS06080	COG1827	regulation of RNA biosynthetic process
G8B42_RS06095	COG2217	Heavy metal translocating P-type atpase
G8B42_RS06110	COG3177	Filamentation induced by cAMP protein fic
G8B42_RS06265	COG3723	Recombinational DNA repair protein, rece pathway
G8B42_RS06310	COG2755	lipolytic protein G-D-S-L family
G8B42_RS06325	COG0497	DNA recombination
G8B42_RS06330	COG1438	arginine binding
G8B42_RS06335	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G8B42_RS06360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8B42_RS06365	COG0415	Belongs to the DNA photolyase family
G8B42_RS06375	COG0765	amino acid transport
G8B42_RS06380	COG4703	Protein of unknown function (DUF1797)
G8B42_RS06385	COG0542	response to heat
G8B42_RS06390	COG0494	nUDIX hydrolase
G8B42_RS06405	COG3599	regulation of cell shape
G8B42_RS06410	COG2302	S4 RNA-binding domain
G8B42_RS06425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G8B42_RS06460	COG1217	gtp-binding protein TYPA
G8B42_RS06465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8B42_RS06470	COG1940	carbohydrate kinase activity
G8B42_RS06480	COG0783	Belongs to the Dps family
G8B42_RS06495	COG4470	Protein conserved in bacteria
G8B42_RS06500	COG1609	Transcriptional regulator
G8B42_RS06505	COG3480	Lon protease (S16) C-terminal proteolytic domain
G8B42_RS06515	COG0742	ribosomal rna small subunit methyltransferase
G8B42_RS06525	COG0549	Belongs to the carbamate kinase family
G8B42_RS06530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8B42_RS06535	COG1288	antiporter activity
G8B42_RS06545	COG0454	-acetyltransferase
G8B42_RS06550	COG2235	arginine
G8B42_RS06575	COG2972	Histidine kinase
G8B42_RS06590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8B42_RS06595	COG0785	Cytochrome C biogenesis protein
G8B42_RS06600	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G8B42_RS06605	COG1518	maintenance of DNA repeat elements
G8B42_RS06665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G8B42_RS06665	COG1605	Chorismate mutase
G8B42_RS06685	COG2226	methyltransferase
G8B42_RS06695	COG3250	beta-galactosidase activity
G8B42_RS06700	COG2207	Transcriptional regulator
G8B42_RS06700	COG4753	response regulator
G8B42_RS06705	COG2972	Histidine kinase
G8B42_RS06715	COG1653	transport
G8B42_RS06720	COG0395	ABC-type sugar transport system, permease component
G8B42_RS06725	COG1175	transmembrane transport
G8B42_RS06730	COG1940	carbohydrate kinase activity
G8B42_RS06735	COG2723	6-phospho-beta-galactosidase activity
G8B42_RS06740	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G8B42_RS06755	COG0383	alpha-mannosidase activity
G8B42_RS06850	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G8B42_RS06855	COG1739	Uncharacterized protein family UPF0029
G8B42_RS06865	COG1098	S1 RNA binding domain
G8B42_RS06875	COG2197	response regulator
G8B42_RS06880	COG4585	Histidine kinase
G8B42_RS06890	COG2815	serine threonine protein kinase
G8B42_RS06890	COG0515	serine threonine protein kinase
G8B42_RS06900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8B42_RS06900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8B42_RS06910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8B42_RS06930	COG0583	DNA-binding transcription factor activity
G8B42_RS06935	COG0183	Belongs to the thiolase family
G8B42_RS06940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8B42_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
G8B42_RS06955	COG2610	gluconate transmembrane transporter activity
G8B42_RS06970	COG0116	Belongs to the methyltransferase superfamily
G8B42_RS06995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8B42_RS07000	COG3579	cysteine-type endopeptidase activity
G8B42_RS07010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G8B42_RS07015	COG1113	amino acid transport
G8B42_RS07020	COG0492	ferredoxin-NADP+ reductase activity
G8B42_RS07030	COG1126	abc transporter atp-binding protein
G8B42_RS07040	COG0513	Belongs to the DEAD box helicase family
G8B42_RS07050	COG0768	penicillin binding
G8B42_RS07085	COG1131	(ABC) transporter
G8B42_RS07110	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8B42_RS07115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8B42_RS07150	COG1755	Isoprenylcysteine carboxyl methyltransferase
G8B42_RS07155	COG0656	L-ascorbic acid biosynthetic process
G8B42_RS07165	COG1283	sodium-dependent phosphate transmembrane transporter activity
G8B42_RS07185	COG0561	phosphatase activity
G8B42_RS07190	COG2860	membrane
G8B42_RS07200	COG1105	Belongs to the carbohydrate kinase PfkB family
G8B42_RS07240	COG2217	Heavy metal translocating P-type atpase
G8B42_RS07270	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G8B42_RS07275	COG0195	Participates in both transcription termination and antitermination
G8B42_RS07300	COG4473	ABC transporter
G8B42_RS07305	COG1131	(ABC) transporter
G8B42_RS07310	COG0537	adenosine 5'-monophosphoramidase activity
G8B42_RS07320	COG1316	TRANSCRIPTIONal
G8B42_RS07330	COG0802	atpase or kinase
G8B42_RS07335	COG2252	PERMEase
G8B42_RS07340	COG0561	phosphatase activity
G8B42_RS07350	COG3715	PTS system
G8B42_RS07355	COG3716	PTS system mannose fructose sorbose family IID component
G8B42_RS07380	COG0439	Biotin carboxylase
G8B42_RS07395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8B42_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
G8B42_RS07405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8B42_RS07430	COG1024	Enoyl-CoA hydratase
G8B42_RS07435	COG0484	heat shock protein binding
G8B42_RS07465	COG0588	phosphoglycerate mutase activity
G8B42_RS07470	COG2261	transglycosylase associated protein
G8B42_RS07500	COG1335	isochorismatase
G8B42_RS07510	COG0436	Aminotransferase
G8B42_RS07520	COG0561	phosphatase activity
G8B42_RS07525	COG0252	asparaginase activity
G8B42_RS07540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8B42_RS07545	COG1129	ABC transporter
G8B42_RS07560	COG1132	(ABC) transporter
G8B42_RS07565	COG4988	ABC transporter
G8B42_RS07570	COG1120	ATPase activity
G8B42_RS07595	COG1388	LysM domain
G8B42_RS07595	COG3942	CHAP domain
G8B42_RS07620	COG1482	cell wall glycoprotein biosynthetic process
G8B42_RS07625	COG1940	carbohydrate kinase activity
G8B42_RS07635	COG1263	PTS System
G8B42_RS07635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B42_RS07635	COG2190	(PTS) system
G8B42_RS07640	COG1621	beta-fructofuranosidase activity
G8B42_RS07645	COG1609	Transcriptional regulator
G8B42_RS07665	COG2131	deaminase
G8B42_RS07670	COG0006	proline dipeptidase activity
G8B42_RS07710	COG1194	a g-specific adenine glycosylase
G8B42_RS07715	COG3620	sequence-specific DNA binding
G8B42_RS07720	COG3118	belongs to the thioredoxin family
G8B42_RS07750	COG0681	Belongs to the peptidase S26 family
G8B42_RS07755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8B42_RS07770	COG1882	Formate acetyltransferase
G8B42_RS07775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G8B42_RS07790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8B42_RS07795	COG2814	Major facilitator Superfamily
G8B42_RS07800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8B42_RS07825	COG0789	Transcriptional regulator
G8B42_RS07840	COG2081	HI0933 family
G8B42_RS07850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G8B42_RS07855	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
G8B42_RS07875	COG0456	acetyltransferase
G8B42_RS07880	COG1214	PFAM Peptidase M22, glycoprotease
G8B42_RS07895	COG0174	glutamine synthetase
G8B42_RS07900	COG0789	Transcriptional regulator
G8B42_RS07915	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G8B42_RS07970	COG0668	transmembrane transport
G8B42_RS07980	COG4720	Psort location CytoplasmicMembrane, score
G8B42_RS07985	COG0351	phosphomethylpyrimidine kinase
G8B42_RS08030	COG1929	Belongs to the glycerate kinase type-1 family
G8B42_RS08035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G8B42_RS08060	COG0577	efflux transmembrane transporter activity
G8B42_RS08065	COG1136	(ABC) transporter
G8B42_RS08070	COG2274	protein secretion by the type I secretion system
G8B42_RS08090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B42_RS08090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B42_RS08095	COG1447	Phosphotransferase system cellobiose-specific component IIA
G8B42_RS08145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8B42_RS08150	COG1476	TRANSCRIPTIONal
G8B42_RS08170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8B42_RS08180	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G8B42_RS08195	COG1045	serine acetyltransferase
G8B42_RS08210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8B42_RS08225	COG3711	transcriptional antiterminator
G8B42_RS08250	COG0431	NADPH-dependent FMN reductase
G8B42_RS08255	COG1846	Transcriptional regulator
G8B42_RS08275	COG4589	Belongs to the CDS family
G8B42_RS08285	COG1862	Preprotein translocase
G8B42_RS08295	COG1523	belongs to the glycosyl hydrolase 13 family
G8B42_RS08305	COG3842	ATPase activity
G8B42_RS08350	COG1263	PTS System
G8B42_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B42_RS08350	COG2190	(PTS) system
G8B42_RS08355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8B42_RS08375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G8B42_RS08380	COG0512	Glutamine amidotransferase of anthranilate synthase
G8B42_RS08385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8B42_RS08425	COG0601	transmembrane transport
G8B42_RS08435	COG1122	ATPase activity
G8B42_RS08455	COG0803	Belongs to the bacterial solute-binding protein 9 family
G8B42_RS08480	COG3711	transcriptional antiterminator
G8B42_RS08490	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B42_RS08490	COG3942	CHAP domain
G8B42_RS08495	COG2205	protein histidine kinase activity
G8B42_RS08500	COG0745	RESPONSE REGULATOR receiver
G8B42_RS08505	COG0577	efflux transmembrane transporter activity
G8B42_RS08510	COG1136	(ABC) transporter
G8B42_RS08575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8B42_RS08590	COG1882	Formate acetyltransferase
G8B42_RS08595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B42_RS08600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B42_RS08605	COG1447	Phosphotransferase system cellobiose-specific component IIA
G8B42_RS08610	COG2390	Transcriptional regulator
G8B42_RS08615	COG1349	DNA-binding transcription factor activity
G8B42_RS08620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G8B42_RS08635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8B42_RS08645	COG0564	pseudouridine synthase activity
G8B42_RS08675	COG0542	response to heat
G8B42_RS08680	COG4463	regulation of RNA biosynthetic process
G8B42_RS08695	COG0450	alkyl hydroperoxide reductase
G8B42_RS08710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G8B42_RS08720	COG3404	Formiminotransferase-cyclodeaminase
G8B42_RS08735	COG0531	amino acid
G8B42_RS08765	COG3590	peptidase
G8B42_RS08770	COG0366	Alpha amylase catalytic
G8B42_RS08775	COG1263	PTS System
G8B42_RS08775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B42_RS08780	COG2188	Transcriptional regulator
G8B42_RS08785	COG1733	regulation of RNA biosynthetic process
G8B42_RS08790	COG2514	catechol 2,3-dioxygenase activity
G8B42_RS08800	COG0602	queuosine metabolic process
G8B42_RS08820	COG1328	CTP reductase activity
G8B42_RS08845	COG1393	Belongs to the ArsC family
G8B42_RS08860	COG0519	Catalyzes the synthesis of GMP from XMP
G8B42_RS08880	COG0582	viral genome integration into host DNA
G8B42_RS08895	COG1396	sequence-specific DNA binding
G8B42_RS08900	COG3617	BRO family, N-terminal domain
G8B42_RS08960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B42_RS08965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B42_RS08970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B42_RS09055	COG1511	domain protein
G8B42_RS09075	COG0305	Participates in initiation and elongation during chromosome replication
G8B42_RS09105	COG1760	l-serine dehydratase
G8B42_RS09110	COG1760	l-serine dehydratase
G8B42_RS09115	COG0741	lytic transglycosylase activity
G8B42_RS09120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G8B42_RS09135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8B42_RS09145	COG0612	Peptidase, M16
G8B42_RS09170	COG0517	IMP dehydrogenase activity
G8B42_RS09170	COG0516	GMP reductase activity
G8B42_RS09180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B42_RS09185	COG0488	(ABC) transporter
G8B42_RS09220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8B42_RS09225	COG1475	DNA binding
G8B42_RS09275	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8B42_RS09370	COG0574	Belongs to the PEP-utilizing enzyme family
G8B42_RS09370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)