locus-tag	class	description
SPAP1_RS00010	COG0592	DNA-directed DNA polymerase activity
SPAP1_RS00020	COG0012	GTP binding
SPAP1_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPAP1_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPAP1_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPAP1_RS00065	COG0531	amino acid
SPAP1_RS00175	COG3942	CHAP domain
SPAP1_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPAP1_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPAP1_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPAP1_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPAP1_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPAP1_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPAP1_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
SPAP1_RS00285	COG1454	alcohol dehydrogenase
SPAP1_RS00290	COG1064	alcohol dehydrogenase
SPAP1_RS00295	COG0534	Mate efflux family protein
SPAP1_RS00405	COG0201	protein transport
SPAP1_RS00540	COG1121	(ABC) transporter
SPAP1_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPAP1_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAP1_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPAP1_RS00585	COG1459	type II secretion system
SPAP1_RS00590	COG4537	Required for transformation and DNA binding
SPAP1_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPAP1_RS00635	COG1363	Peptidase, m42
SPAP1_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAP1_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPAP1_RS00660	COG1428	Deoxynucleoside kinase
SPAP1_RS00665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPAP1_RS00695	COG4509	Sortase family
SPAP1_RS00705	COG4372	Transposase
SPAP1_RS00730	COG2031	fatty acid transporter
SPAP1_RS00750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPAP1_RS00765	COG0251	oxidation-reduction process
SPAP1_RS00780	COG1269	ATP hydrolysis coupled proton transport
SPAP1_RS00785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPAP1_RS00795	COG1527	subunit (C
SPAP1_RS00800	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPAP1_RS00835	COG1744	ABC transporter substrate-binding protein PnrA-like
SPAP1_RS00880	COG0626	cystathionine gamma-synthase activity
SPAP1_RS00910	COG3623	hexulose-6-phosphate isomerase
SPAP1_RS00930	COG4175	Glycine betaine
SPAP1_RS00930	COG3448	diguanylate cyclase activity
SPAP1_RS00940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPAP1_RS00940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPAP1_RS00960	COG3969	phosphoadenosine phosphosulfate
SPAP1_RS00965	COG1475	DNA binding
SPAP1_RS00975	COG2801	Transposase and inactivated derivatives
SPAP1_RS00985	COG2801	Transposase and inactivated derivatives
SPAP1_RS01000	COG0157	Belongs to the NadC ModD family
SPAP1_RS01005	COG2801	Transposase and inactivated derivatives
SPAP1_RS01025	COG1268	BioY protein
SPAP1_RS01030	COG1234	tRNA 3'-trailer cleavage
SPAP1_RS01060	COG5433	transposase activity
SPAP1_RS01070	COG0457	Tetratricopeptide repeat
SPAP1_RS01070	COG0705	Rhomboid family
SPAP1_RS01090	COG1132	(ABC) transporter
SPAP1_RS01095	COG1132	(ABC) transporter
SPAP1_RS01105	COG0756	dUTP diphosphatase activity
SPAP1_RS01130	COG3290	protein histidine kinase activity
SPAP1_RS01155	COG1847	R3H domain protein
SPAP1_RS01175	COG1175	transmembrane transport
SPAP1_RS01180	COG0395	ABC-type sugar transport system, permease component
SPAP1_RS01190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPAP1_RS01205	COG0084	hydrolase, TatD family'
SPAP1_RS01230	COG1564	THIamine pyrophosphokinase
SPAP1_RS01245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPAP1_RS01280	COG0765	amino acid transport
SPAP1_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPAP1_RS01310	COG0719	Fe-S assembly protein
SPAP1_RS01315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPAP1_RS01330	COG1686	Belongs to the peptidase S11 family
SPAP1_RS01335	COG1686	Belongs to the peptidase S11 family
SPAP1_RS01340	COG4166	transmembrane transport
SPAP1_RS01345	COG0601	transmembrane transport
SPAP1_RS01350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPAP1_RS01355	COG0444	Belongs to the ABC transporter superfamily
SPAP1_RS01410	COG0351	phosphomethylpyrimidine kinase
SPAP1_RS01415	COG4720	Psort location CytoplasmicMembrane, score
SPAP1_RS01425	COG0668	transmembrane transport
SPAP1_RS01480	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPAP1_RS01495	COG0789	Transcriptional regulator
SPAP1_RS01500	COG0174	glutamine synthetase
SPAP1_RS01515	COG1214	PFAM Peptidase M22, glycoprotease
SPAP1_RS01520	COG0456	acetyltransferase
SPAP1_RS01540	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPAP1_RS01545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPAP1_RS01555	COG2081	HI0933 family
SPAP1_RS01570	COG0789	Transcriptional regulator
SPAP1_RS01595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPAP1_RS01600	COG2814	Major facilitator Superfamily
SPAP1_RS01605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPAP1_RS01620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPAP1_RS01625	COG1882	Formate acetyltransferase
SPAP1_RS01640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPAP1_RS01645	COG0681	Belongs to the peptidase S26 family
SPAP1_RS01675	COG3118	belongs to the thioredoxin family
SPAP1_RS01685	COG1194	a g-specific adenine glycosylase
SPAP1_RS01725	COG0006	proline dipeptidase activity
SPAP1_RS01730	COG2131	deaminase
SPAP1_RS01750	COG1609	Transcriptional regulator
SPAP1_RS01755	COG1621	beta-fructofuranosidase activity
SPAP1_RS01760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP1_RS01760	COG2190	(PTS) system
SPAP1_RS01760	COG1263	PTS System
SPAP1_RS01770	COG1940	carbohydrate kinase activity
SPAP1_RS01775	COG1482	cell wall glycoprotein biosynthetic process
SPAP1_RS01780	COG5433	transposase activity
SPAP1_RS01805	COG3942	CHAP domain
SPAP1_RS01805	COG1388	LysM domain
SPAP1_RS01830	COG1120	ATPase activity
SPAP1_RS01835	COG4988	ABC transporter
SPAP1_RS01840	COG1132	(ABC) transporter
SPAP1_RS01855	COG1129	ABC transporter
SPAP1_RS01860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPAP1_RS01875	COG0252	asparaginase activity
SPAP1_RS01880	COG0561	phosphatase activity
SPAP1_RS01890	COG0436	Aminotransferase
SPAP1_RS01900	COG1335	isochorismatase
SPAP1_RS01905	COG0574	Belongs to the PEP-utilizing enzyme family
SPAP1_RS01905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPAP1_RS01930	COG2261	transglycosylase associated protein
SPAP1_RS01935	COG0588	phosphoglycerate mutase activity
SPAP1_RS01970	COG1024	Enoyl-CoA hydratase
SPAP1_RS01995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPAP1_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP1_RS02005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPAP1_RS02020	COG0439	Biotin carboxylase
SPAP1_RS02045	COG3716	PTS system mannose fructose sorbose family IID component
SPAP1_RS02050	COG3715	PTS system
SPAP1_RS02060	COG0561	phosphatase activity
SPAP1_RS02065	COG2252	PERMEase
SPAP1_RS02070	COG0802	atpase or kinase
SPAP1_RS02080	COG1316	TRANSCRIPTIONal
SPAP1_RS02090	COG0537	adenosine 5'-monophosphoramidase activity
SPAP1_RS02095	COG1131	(ABC) transporter
SPAP1_RS02100	COG4473	ABC transporter
SPAP1_RS02125	COG0195	Participates in both transcription termination and antitermination
SPAP1_RS02130	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPAP1_RS02160	COG2217	Heavy metal translocating P-type atpase
SPAP1_RS02210	COG2860	membrane
SPAP1_RS02215	COG0561	phosphatase activity
SPAP1_RS02235	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPAP1_RS02245	COG0656	L-ascorbic acid biosynthetic process
SPAP1_RS02250	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPAP1_RS02285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPAP1_RS02290	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPAP1_RS02315	COG1131	(ABC) transporter
SPAP1_RS02355	COG0768	penicillin binding
SPAP1_RS02365	COG0513	Belongs to the DEAD box helicase family
SPAP1_RS02375	COG1126	abc transporter atp-binding protein
SPAP1_RS02385	COG0492	ferredoxin-NADP+ reductase activity
SPAP1_RS02390	COG1113	amino acid transport
SPAP1_RS02395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPAP1_RS02405	COG3579	cysteine-type endopeptidase activity
SPAP1_RS02410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAP1_RS02435	COG0116	Belongs to the methyltransferase superfamily
SPAP1_RS02450	COG2610	gluconate transmembrane transporter activity
SPAP1_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP1_RS02465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPAP1_RS02470	COG0183	Belongs to the thiolase family
SPAP1_RS02475	COG0583	DNA-binding transcription factor activity
SPAP1_RS02495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPAP1_RS02505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPAP1_RS02505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPAP1_RS02515	COG0515	serine threonine protein kinase
SPAP1_RS02515	COG2815	serine threonine protein kinase
SPAP1_RS02525	COG4585	Histidine kinase
SPAP1_RS02530	COG2197	response regulator
SPAP1_RS02540	COG1098	S1 RNA binding domain
SPAP1_RS02550	COG1739	Uncharacterized protein family UPF0029
SPAP1_RS02555	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPAP1_RS02660	COG3561	AntA/AntB antirepressor
SPAP1_RS02875	COG4824	toxin secretion phage lysis holin
SPAP1_RS02885	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPAP1_RS02885	COG1388	LysM domain
SPAP1_RS02925	COG0383	alpha-mannosidase activity
SPAP1_RS02940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPAP1_RS02945	COG2723	6-phospho-beta-galactosidase activity
SPAP1_RS02950	COG1940	carbohydrate kinase activity
SPAP1_RS02955	COG1175	transmembrane transport
SPAP1_RS02960	COG0395	ABC-type sugar transport system, permease component
SPAP1_RS02965	COG1653	transport
SPAP1_RS02975	COG2972	Histidine kinase
SPAP1_RS02980	COG2207	Transcriptional regulator
SPAP1_RS02980	COG4753	response regulator
SPAP1_RS02985	COG3250	beta-galactosidase activity
SPAP1_RS02995	COG2226	methyltransferase
SPAP1_RS03015	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPAP1_RS03015	COG1605	Chorismate mutase
SPAP1_RS03075	COG1518	maintenance of DNA repeat elements
SPAP1_RS03080	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPAP1_RS03085	COG0785	Cytochrome C biogenesis protein
SPAP1_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPAP1_RS03105	COG2972	Histidine kinase
SPAP1_RS03130	COG2235	arginine
SPAP1_RS03145	COG1288	antiporter activity
SPAP1_RS03150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPAP1_RS03155	COG0549	Belongs to the carbamate kinase family
SPAP1_RS03165	COG0742	ribosomal rna small subunit methyltransferase
SPAP1_RS03175	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPAP1_RS03180	COG1609	Transcriptional regulator
SPAP1_RS03185	COG4470	Protein conserved in bacteria
SPAP1_RS03200	COG0783	Belongs to the Dps family
SPAP1_RS03210	COG1940	carbohydrate kinase activity
SPAP1_RS03215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPAP1_RS03220	COG1217	gtp-binding protein TYPA
SPAP1_RS03255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPAP1_RS03270	COG2302	S4 RNA-binding domain
SPAP1_RS03275	COG3599	regulation of cell shape
SPAP1_RS03290	COG0494	nUDIX hydrolase
SPAP1_RS03295	COG0542	response to heat
SPAP1_RS03300	COG4703	Protein of unknown function (DUF1797)
SPAP1_RS03305	COG0765	amino acid transport
SPAP1_RS03315	COG0415	Belongs to the DNA photolyase family
SPAP1_RS03320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPAP1_RS03345	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPAP1_RS03350	COG1438	arginine binding
SPAP1_RS03355	COG0497	DNA recombination
SPAP1_RS03370	COG2755	lipolytic protein G-D-S-L family
SPAP1_RS03385	COG0582	viral genome integration into host DNA
SPAP1_RS03395	COG1396	sequence-specific DNA binding
SPAP1_RS03440	COG3723	Recombinational DNA repair protein, rece pathway
SPAP1_RS03635	COG2217	Heavy metal translocating P-type atpase
SPAP1_RS03650	COG1827	regulation of RNA biosynthetic process
SPAP1_RS03660	COG2116	formate transmembrane transporter activity
SPAP1_RS03665	COG0768	penicillin binding
SPAP1_RS03680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPAP1_RS03695	COG0513	Belongs to the DEAD box helicase family
SPAP1_RS03710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPAP1_RS03715	COG0204	Acyl-transferase
SPAP1_RS03720	COG1555	photosystem II stabilization
SPAP1_RS03720	COG1596	polysaccharide export
SPAP1_RS03725	COG2333	competence protein COMEC
SPAP1_RS03725	COG0658	competence protein
SPAP1_RS03770	COG1187	pseudouridine synthase activity
SPAP1_RS03785	COG2223	nitrite transmembrane transporter activity
SPAP1_RS03790	COG4122	O-methyltransferase activity
SPAP1_RS03805	COG1476	TRANSCRIPTIONal
SPAP1_RS03820	COG2801	Transposase and inactivated derivatives
SPAP1_RS03830	COG2801	Transposase and inactivated derivatives
SPAP1_RS03845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPAP1_RS03850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPAP1_RS03855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPAP1_RS03875	COG0726	polysaccharide deacetylase
SPAP1_RS03880	COG0513	Belongs to the DEAD box helicase family
SPAP1_RS03900	COG1956	GAF domain-containing protein
SPAP1_RS03905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPAP1_RS03910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPAP1_RS03910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPAP1_RS03940	COG4109	DRTGG domain
SPAP1_RS03990	COG2814	Major facilitator Superfamily
SPAP1_RS04000	COG1187	pseudouridine synthase activity
SPAP1_RS04005	COG2801	Transposase and inactivated derivatives
SPAP1_RS04030	COG2723	6-phospho-beta-galactosidase activity
SPAP1_RS04040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAP1_RS04040	COG3711	transcriptional antiterminator
SPAP1_RS04050	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP1_RS04060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP1_RS04065	COG1126	abc transporter atp-binding protein
SPAP1_RS04070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP1_RS04090	COG1696	Membrane protein involved in D-alanine export
SPAP1_RS04100	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPAP1_RS04105	COG0657	acetylesterase activity
SPAP1_RS04115	COG2182	Extracellular solute-binding protein
SPAP1_RS04120	COG0366	Alpha amylase catalytic
SPAP1_RS04130	COG1175	transmembrane transport
SPAP1_RS04135	COG3833	ABC-type maltose transport systems, permease component
SPAP1_RS04150	COG3833	ABC-type maltose transport systems, permease component
SPAP1_RS04155	COG1175	transmembrane transport
SPAP1_RS04160	COG2182	Extracellular solute-binding protein
SPAP1_RS04165	COG1609	Transcriptional regulator
SPAP1_RS04170	COG1640	4-alpha-glucanotransferase
SPAP1_RS04175	COG0058	SHG alpha-glucan phosphorylase activity
SPAP1_RS04215	COG1396	sequence-specific DNA binding
SPAP1_RS04325	COG1783	phage Terminase large subunit
SPAP1_RS04480	COG1131	(ABC) transporter
SPAP1_RS04485	COG1725	Transcriptional regulator
SPAP1_RS04500	COG0469	pyruvate kinase activity
SPAP1_RS04515	COG2824	Alkylphosphonate utilization operon protein PhnA
SPAP1_RS04520	COG0765	amino acid transport
SPAP1_RS04525	COG1126	abc transporter atp-binding protein
SPAP1_RS04530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP1_RS04540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPAP1_RS04545	COG1115	amino acid carrier protein
SPAP1_RS04595	COG1136	(ABC) transporter
SPAP1_RS04595	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPAP1_RS04625	COG0196	riboflavin kinase activity
SPAP1_RS04640	COG0483	inositol monophosphate 1-phosphatase activity
SPAP1_RS04645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPAP1_RS04645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPAP1_RS04655	COG0573	inorganic phosphate transmembrane transporter activity
SPAP1_RS04660	COG0581	inorganic phosphate transmembrane transporter activity
SPAP1_RS04675	COG0704	Plays a role in the regulation of phosphate uptake
SPAP1_RS04685	COG0745	RESPONSE REGULATOR receiver
SPAP1_RS04690	COG5002	protein histidine kinase activity
SPAP1_RS04705	COG2813	Specifically methylates the guanine in position
SPAP1_RS04710	COG0295	cytidine deaminase activity
SPAP1_RS04715	COG1744	ABC transporter substrate-binding protein PnrA-like
SPAP1_RS04720	COG3845	ABC transporter
SPAP1_RS04725	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPAP1_RS04730	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPAP1_RS04735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPAP1_RS04740	COG4684	Psort location CytoplasmicMembrane, score
SPAP1_RS04745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPAP1_RS04765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPAP1_RS04795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPAP1_RS04800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPAP1_RS04800	COG1328	CTP reductase activity
SPAP1_RS04805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPAP1_RS04810	COG0351	phosphomethylpyrimidine kinase
SPAP1_RS04810	COG0352	thiamine-phosphate diphosphorylase activity
SPAP1_RS04820	COG0488	(ABC) transporter
SPAP1_RS04840	COG2188	Transcriptional regulator
SPAP1_RS04850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPAP1_RS04870	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPAP1_RS04905	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPAP1_RS04910	COG0511	ligase activity, forming carbon-carbon bonds
SPAP1_RS04920	COG2851	Citrate transporter
SPAP1_RS04935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPAP1_RS04940	COG0511	ligase activity, forming carbon-carbon bonds
SPAP1_RS04985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPAP1_RS04990	COG0758	DNA mediated transformation
SPAP1_RS05010	COG1272	protein, Hemolysin III
SPAP1_RS05025	COG0346	lactoylglutathione lyase activity
SPAP1_RS05030	COG3764	Sortase (surface protein transpeptidase)
SPAP1_RS05050	COG1132	(ABC) transporter
SPAP1_RS05055	COG1132	(ABC) transporter
SPAP1_RS05085	COG2890	protein-(glutamine-N5) methyltransferase activity
SPAP1_RS05110	COG2233	PERMEase
SPAP1_RS05125	COG1174	glycine betaine transport
SPAP1_RS05145	COG0280	phosphate acetyltransferase
SPAP1_RS05150	COG0564	pseudouridine synthase activity
SPAP1_RS05160	COG2357	RelA SpoT domain protein
SPAP1_RS05175	COG1104	cysteine desulfurase activity
SPAP1_RS05190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPAP1_RS05200	COG0628	permease
SPAP1_RS05210	COG0038	chloride channel
SPAP1_RS05215	COG3700	Belongs to the class B bacterial acid phosphatase family
SPAP1_RS05230	COG3493	citrate carrier protein
SPAP1_RS05235	COG3290	protein histidine kinase activity
SPAP1_RS05240	COG4565	transcriptional regulatory protein
SPAP1_RS05250	COG1177	transmembrane transport
SPAP1_RS05255	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPAP1_RS05270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPAP1_RS05290	COG0285	dihydrofolate synthase activity
SPAP1_RS05325	COG1396	sequence-specific DNA binding
SPAP1_RS05340	COG1131	(ABC) transporter
SPAP1_RS05400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPAP1_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
SPAP1_RS05420	COG1011	Hydrolase
SPAP1_RS05435	COG1840	ABC-type Fe3 transport system, periplasmic component
SPAP1_RS05440	COG2207	Transcriptional regulator
SPAP1_RS05440	COG4753	response regulator
SPAP1_RS05445	COG2972	Histidine kinase
SPAP1_RS05450	COG3716	PTS system mannose fructose sorbose family IID component
SPAP1_RS05455	COG3715	PTS system
SPAP1_RS05490	COG0105	UTP biosynthetic process
SPAP1_RS05525	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPAP1_RS05620	COG0740	serine-type endopeptidase activity
SPAP1_RS05665	COG0582	viral genome integration into host DNA
SPAP1_RS05735	COG0305	Participates in initiation and elongation during chromosome replication
SPAP1_RS05790	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPAP1_RS05795	COG1518	maintenance of DNA repeat elements
SPAP1_RS05810	COG0647	UMP catabolic process
SPAP1_RS05820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPAP1_RS05840	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPAP1_RS05845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPAP1_RS05850	COG3442	glutamine amidotransferase
SPAP1_RS05855	COG0095	Lipoate-protein ligase
SPAP1_RS05860	COG5492	domain, Protein
SPAP1_RS05880	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPAP1_RS05880	COG0022	dehydrogenase e1 component
SPAP1_RS05885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPAP1_RS05890	COG0488	(ABC) transporter
SPAP1_RS05910	COG1129	ABC transporter
SPAP1_RS05930	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPAP1_RS05935	COG0457	Tetratricopeptide repeat
SPAP1_RS05940	COG0628	permease
SPAP1_RS05945	COG1051	belongs to the nudix hydrolase family
SPAP1_RS05950	COG1088	dTDP-glucose 4,6-dehydratase activity
SPAP1_RS05960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPAP1_RS05965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPAP1_RS05975	COG2384	SAM-dependent methyltransferase
SPAP1_RS05980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPAP1_RS05995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPAP1_RS05995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPAP1_RS06000	COG0300	oxidoreductase activity
SPAP1_RS06010	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPAP1_RS06015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPAP1_RS06050	COG0539	negative regulation of cytoplasmic translation
SPAP1_RS06070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPAP1_RS06080	COG0187	DNA topoisomerase II activity
SPAP1_RS06100	COG0765	amino acid transport
SPAP1_RS06105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP1_RS06130	COG0583	DNA-binding transcription factor activity
SPAP1_RS06190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPAP1_RS06200	COG3425	synthase
SPAP1_RS06235	COG0745	RESPONSE REGULATOR receiver
SPAP1_RS06240	COG2357	RelA SpoT domain protein
SPAP1_RS06245	COG0737	Belongs to the 5'-nucleotidase family
SPAP1_RS06250	COG0242	peptide deformylase activity
SPAP1_RS06260	COG0488	(ABC) transporter
SPAP1_RS06280	COG0105	UTP biosynthetic process
SPAP1_RS06295	COG2801	Transposase and inactivated derivatives
SPAP1_RS06300	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPAP1_RS06300	COG1388	LysM domain
SPAP1_RS06305	COG1388	LysM domain
SPAP1_RS06305	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPAP1_RS06310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPAP1_RS06310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPAP1_RS06310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPAP1_RS06315	COG1105	Belongs to the carbohydrate kinase PfkB family
SPAP1_RS06320	COG1349	DNA-binding transcription factor activity
SPAP1_RS06370	COG1837	Belongs to the UPF0109 family
SPAP1_RS06380	COG0584	glycerophosphoryl diester phosphodiesterase
SPAP1_RS06385	COG0577	efflux transmembrane transporter activity
SPAP1_RS06390	COG1136	(ABC) transporter
SPAP1_RS06395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPAP1_RS06425	COG0564	pseudouridine synthase activity
SPAP1_RS06435	COG0583	DNA-binding transcription factor activity
SPAP1_RS06440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPAP1_RS06465	COG1104	cysteine desulfurase activity
SPAP1_RS06475	COG0285	dihydrofolate synthase activity
SPAP1_RS06480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPAP1_RS06500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPAP1_RS06505	COG1368	sulfuric ester hydrolase activity
SPAP1_RS06560	COG1216	Glycosyl transferase, family 2
SPAP1_RS06605	COG2151	metal-sulfur cluster biosynthetic enzyme
SPAP1_RS06610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPAP1_RS06615	COG0358	DNA primase activity
SPAP1_RS06620	COG1970	mechanosensitive ion channel activity
SPAP1_RS06630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP1_RS06645	COG2321	neutral zinc metallopeptidase
SPAP1_RS06655	COG0577	efflux transmembrane transporter activity
SPAP1_RS06740	COG1597	lipid kinase activity
SPAP1_RS06750	COG4708	membrane
SPAP1_RS06770	COG1131	(ABC) transporter
SPAP1_RS06860	COG0038	chloride channel
SPAP1_RS06870	COG0716	FMN binding
SPAP1_RS06875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPAP1_RS06885	COG2222	sugar isomerase
SPAP1_RS06890	COG2188	Transcriptional regulator
SPAP1_RS06930	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPAP1_RS06930	COG1388	LysM domain
SPAP1_RS07025	COG0740	serine-type endopeptidase activity
SPAP1_RS07065	COG1598	PFAM Uncharacterised protein family UPF0150
SPAP1_RS07135	COG3723	Recombinational DNA repair protein, rece pathway
SPAP1_RS07190	COG3620	sequence-specific DNA binding
SPAP1_RS07225	COG0436	Aminotransferase
SPAP1_RS07230	COG1199	ATP-dependent helicase activity
SPAP1_RS07230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPAP1_RS07245	COG2177	Part of the ABC transporter FtsEX involved in
SPAP1_RS07250	COG2884	Cell division ATP-binding protein ftsE
SPAP1_RS07260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPAP1_RS07265	COG0546	phosphoglycolate phosphatase activity
SPAP1_RS07270	COG0800	Aldolase
SPAP1_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP1_RS07300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP1_RS07305	COG3715	PTS system
SPAP1_RS07310	COG3716	PTS system mannose fructose sorbose family IID component
SPAP1_RS07320	COG1609	Transcriptional regulator
SPAP1_RS07335	COG1078	dGTPase activity
SPAP1_RS07370	COG0772	Belongs to the SEDS family
SPAP1_RS07380	COG1164	Oligoendopeptidase f
SPAP1_RS07385	COG0386	Belongs to the glutathione peroxidase family
SPAP1_RS07435	COG4443	Transcriptional Coactivator p15 (PC4)
SPAP1_RS07440	COG0826	peptidase U32
SPAP1_RS07485	COG2183	response to ionizing radiation
SPAP1_RS07495	COG0701	Predicted permease
SPAP1_RS07500	COG3689	TIGRFAM TIGR03943 family protein
SPAP1_RS07510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP1_RS07510	COG1263	PTS System
SPAP1_RS07510	COG2190	(PTS) system
SPAP1_RS07515	COG3711	transcriptional antiterminator
SPAP1_RS07520	COG0477	Major facilitator Superfamily
SPAP1_RS07525	COG0552	protein localization to endoplasmic reticulum
SPAP1_RS07530	COG0561	phosphatase activity
SPAP1_RS07535	COG0561	phosphatase activity
SPAP1_RS07585	COG4695	Portal protein
SPAP1_RS07665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPAP1_RS07675	COG1196	nuclear chromosome segregation
SPAP1_RS07685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPAP1_RS07690	COG5002	protein histidine kinase activity
SPAP1_RS07695	COG0745	RESPONSE REGULATOR receiver
SPAP1_RS07710	COG0183	Belongs to the thiolase family
SPAP1_RS07725	COG4555	ABC transporter
SPAP1_RS07735	COG0438	transferase activity, transferring glycosyl groups
SPAP1_RS07745	COG1609	Transcriptional regulator
SPAP1_RS07750	COG0006	proline dipeptidase activity
SPAP1_RS07755	COG0778	Nitroreductase
SPAP1_RS07765	COG0463	Glycosyl transferase, family 2
SPAP1_RS07795	COG0557	exoribonuclease II activity
SPAP1_RS07805	COG2814	Major facilitator Superfamily
SPAP1_RS07810	COG0433	COG0433 Predicted ATPase
SPAP1_RS07890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPAP1_RS07900	COG1573	uracil-dna glycosylase
SPAP1_RS07905	COG1702	phosphate starvation-inducible protein PhoH
SPAP1_RS07995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPAP1_RS08005	COG0494	nUDIX hydrolase
SPAP1_RS08020	COG0673	inositol 2-dehydrogenase activity
SPAP1_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
SPAP1_RS08105	COG1304	FMN binding
SPAP1_RS08115	COG0708	Exodeoxyribonuclease III
SPAP1_RS08120	COG1393	Belongs to the ArsC family
SPAP1_RS08155	COG0470	DNA polymerase III
SPAP1_RS08180	COG2244	polysaccharide biosynthetic process
SPAP1_RS08190	COG1120	ATPase activity
SPAP1_RS08195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPAP1_RS08200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPAP1_RS08205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPAP1_RS08220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPAP1_RS08225	COG1253	flavin adenine dinucleotide binding
SPAP1_RS08230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPAP1_RS08235	COG1242	4 iron, 4 sulfur cluster binding
SPAP1_RS08240	COG0671	phosphoesterase, PA-phosphatase related
SPAP1_RS08245	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPAP1_RS08260	COG1187	pseudouridine synthase activity
SPAP1_RS08315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPAP1_RS08320	COG5433	transposase activity
SPAP1_RS08335	COG1254	Belongs to the acylphosphatase family
SPAP1_RS08350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPAP1_RS08370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPAP1_RS08380	COG1484	DNA-dependent DNA replication
SPAP1_RS08400	COG0745	RESPONSE REGULATOR receiver
SPAP1_RS08415	COG1704	LemA family
SPAP1_RS08425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPAP1_RS08430	COG0569	domain protein
SPAP1_RS08440	COG1114	Component of the transport system for branched-chain amino acids
SPAP1_RS08455	COG1464	Belongs to the NlpA lipoprotein family
SPAP1_RS08460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPAP1_RS08475	COG2226	methyltransferase
SPAP1_RS08480	COG0799	negative regulation of ribosome biogenesis
SPAP1_RS08485	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPAP1_RS08495	COG1534	Rna-binding protein
SPAP1_RS08500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPAP1_RS08505	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPAP1_RS08520	COG5433	transposase activity
SPAP1_RS08560	COG1929	Belongs to the glycerate kinase type-1 family
SPAP1_RS08565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPAP1_RS08595	COG0577	efflux transmembrane transporter activity
SPAP1_RS08600	COG1136	(ABC) transporter
SPAP1_RS08625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP1_RS08625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP1_RS08630	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP1_RS08680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPAP1_RS08685	COG1476	TRANSCRIPTIONal
SPAP1_RS08705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPAP1_RS08715	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPAP1_RS08730	COG1045	serine acetyltransferase
SPAP1_RS08745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPAP1_RS08750	COG3037	sugar-specific permease SgaT UlaA
SPAP1_RS08760	COG3711	transcriptional antiterminator
SPAP1_RS08785	COG1846	Transcriptional regulator
SPAP1_RS08805	COG4589	Belongs to the CDS family
SPAP1_RS08815	COG1862	Preprotein translocase
SPAP1_RS08825	COG1523	belongs to the glycosyl hydrolase 13 family
SPAP1_RS08835	COG3842	ATPase activity
SPAP1_RS08875	COG2190	(PTS) system
SPAP1_RS08875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP1_RS08875	COG1263	PTS System
SPAP1_RS08880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPAP1_RS08895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPAP1_RS08900	COG0512	Glutamine amidotransferase of anthranilate synthase
SPAP1_RS08905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPAP1_RS08940	COG0601	transmembrane transport
SPAP1_RS08950	COG1122	ATPase activity
SPAP1_RS08970	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPAP1_RS09005	COG3711	transcriptional antiterminator
SPAP1_RS09015	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPAP1_RS09015	COG3942	CHAP domain
SPAP1_RS09020	COG2205	protein histidine kinase activity
SPAP1_RS09025	COG0745	RESPONSE REGULATOR receiver
SPAP1_RS09030	COG0577	efflux transmembrane transporter activity
SPAP1_RS09035	COG1136	(ABC) transporter
SPAP1_RS09085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPAP1_RS09100	COG1882	Formate acetyltransferase
SPAP1_RS09105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP1_RS09110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPAP1_RS09115	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPAP1_RS09120	COG2390	Transcriptional regulator
SPAP1_RS09125	COG1349	DNA-binding transcription factor activity
SPAP1_RS09130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPAP1_RS09145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPAP1_RS09160	COG0564	pseudouridine synthase activity
SPAP1_RS09190	COG0542	response to heat
SPAP1_RS09195	COG4463	regulation of RNA biosynthetic process
SPAP1_RS09210	COG0450	alkyl hydroperoxide reductase
SPAP1_RS09225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPAP1_RS09235	COG3404	Formiminotransferase-cyclodeaminase
SPAP1_RS09250	COG0531	amino acid
SPAP1_RS09280	COG3590	peptidase
SPAP1_RS09285	COG0366	Alpha amylase catalytic
SPAP1_RS09290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPAP1_RS09290	COG1263	PTS System
SPAP1_RS09295	COG2188	Transcriptional regulator
SPAP1_RS09305	COG2514	catechol 2,3-dioxygenase activity
SPAP1_RS09315	COG0602	queuosine metabolic process
SPAP1_RS09330	COG1328	CTP reductase activity
SPAP1_RS09355	COG1393	Belongs to the ArsC family
SPAP1_RS09370	COG0519	Catalyzes the synthesis of GMP from XMP
SPAP1_RS09380	COG2814	Major facilitator Superfamily
SPAP1_RS09415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAP1_RS09420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAP1_RS09425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAP1_RS09505	COG1511	domain protein
SPAP1_RS09525	COG5433	transposase activity
SPAP1_RS09535	COG0305	Participates in initiation and elongation during chromosome replication
SPAP1_RS09565	COG1760	l-serine dehydratase
SPAP1_RS09570	COG1760	l-serine dehydratase
SPAP1_RS09575	COG0741	lytic transglycosylase activity
SPAP1_RS09580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPAP1_RS09595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPAP1_RS09605	COG0612	Peptidase, M16
SPAP1_RS09615	COG1215	transferase activity, transferring glycosyl groups
SPAP1_RS09645	COG0517	IMP dehydrogenase activity
SPAP1_RS09645	COG0516	GMP reductase activity
SPAP1_RS09655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPAP1_RS09660	COG0488	(ABC) transporter
SPAP1_RS09700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPAP1_RS09705	COG1475	DNA binding