locus-tag	class	description
SPYALAB49_RS00005	COG1475	DNA binding
SPYALAB49_RS00015	COG0592	DNA-directed DNA polymerase activity
SPYALAB49_RS00025	COG0012	GTP binding
SPYALAB49_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYALAB49_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYALAB49_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYALAB49_RS00070	COG0531	amino acid
SPYALAB49_RS00245	COG3942	CHAP domain
SPYALAB49_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYALAB49_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYALAB49_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYALAB49_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYALAB49_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYALAB49_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYALAB49_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
SPYALAB49_RS00355	COG1454	alcohol dehydrogenase
SPYALAB49_RS00360	COG1064	alcohol dehydrogenase
SPYALAB49_RS00365	COG0534	Mate efflux family protein
SPYALAB49_RS00475	COG0201	protein transport
SPYALAB49_RS00610	COG1121	(ABC) transporter
SPYALAB49_RS00615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYALAB49_RS00630	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPYALAB49_RS00630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYALAB49_RS00650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYALAB49_RS00655	COG1459	type II secretion system
SPYALAB49_RS00660	COG4537	Required for transformation and DNA binding
SPYALAB49_RS00700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYALAB49_RS00705	COG1363	Peptidase, m42
SPYALAB49_RS00715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYALAB49_RS00720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYALAB49_RS00730	COG1428	Deoxynucleoside kinase
SPYALAB49_RS00735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYALAB49_RS00765	COG4509	Sortase family
SPYALAB49_RS00790	COG2031	fatty acid transporter
SPYALAB49_RS00805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYALAB49_RS00820	COG0251	oxidation-reduction process
SPYALAB49_RS00835	COG1269	ATP hydrolysis coupled proton transport
SPYALAB49_RS00840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYALAB49_RS00850	COG1527	subunit (C
SPYALAB49_RS00855	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYALAB49_RS00890	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYALAB49_RS00920	COG0626	cystathionine gamma-synthase activity
SPYALAB49_RS00950	COG3623	hexulose-6-phosphate isomerase
SPYALAB49_RS00970	COG4175	Glycine betaine
SPYALAB49_RS00970	COG3448	diguanylate cyclase activity
SPYALAB49_RS00980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYALAB49_RS00980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYALAB49_RS01000	COG3969	phosphoadenosine phosphosulfate
SPYALAB49_RS01005	COG1475	DNA binding
SPYALAB49_RS01015	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS01020	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS01035	COG0157	Belongs to the NadC ModD family
SPYALAB49_RS01040	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS01065	COG1268	BioY protein
SPYALAB49_RS01070	COG1234	tRNA 3'-trailer cleavage
SPYALAB49_RS01100	COG0457	Tetratricopeptide repeat
SPYALAB49_RS01100	COG0705	Rhomboid family
SPYALAB49_RS01120	COG1132	(ABC) transporter
SPYALAB49_RS01125	COG1132	(ABC) transporter
SPYALAB49_RS01135	COG0756	dUTP diphosphatase activity
SPYALAB49_RS01160	COG3290	protein histidine kinase activity
SPYALAB49_RS01185	COG1847	R3H domain protein
SPYALAB49_RS01205	COG1175	transmembrane transport
SPYALAB49_RS01210	COG0395	ABC-type sugar transport system, permease component
SPYALAB49_RS01220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYALAB49_RS01235	COG0084	hydrolase, TatD family'
SPYALAB49_RS01260	COG1564	THIamine pyrophosphokinase
SPYALAB49_RS01275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYALAB49_RS01300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SPYALAB49_RS01310	COG0765	amino acid transport
SPYALAB49_RS01330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYALAB49_RS01340	COG0719	Fe-S assembly protein
SPYALAB49_RS01345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYALAB49_RS01360	COG1686	Belongs to the peptidase S11 family
SPYALAB49_RS01365	COG1686	Belongs to the peptidase S11 family
SPYALAB49_RS01370	COG4166	transmembrane transport
SPYALAB49_RS01375	COG0601	transmembrane transport
SPYALAB49_RS01380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYALAB49_RS01385	COG0444	Belongs to the ABC transporter superfamily
SPYALAB49_RS01435	COG5433	transposase activity
SPYALAB49_RS01445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYALAB49_RS01450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYALAB49_RS01455	COG1534	Rna-binding protein
SPYALAB49_RS01465	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYALAB49_RS01470	COG0799	negative regulation of ribosome biogenesis
SPYALAB49_RS01475	COG2226	methyltransferase
SPYALAB49_RS01490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYALAB49_RS01495	COG1464	Belongs to the NlpA lipoprotein family
SPYALAB49_RS01510	COG1114	Component of the transport system for branched-chain amino acids
SPYALAB49_RS01520	COG0569	domain protein
SPYALAB49_RS01525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYALAB49_RS01535	COG1704	LemA family
SPYALAB49_RS01550	COG0745	RESPONSE REGULATOR receiver
SPYALAB49_RS01570	COG1484	DNA-dependent DNA replication
SPYALAB49_RS01580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYALAB49_RS01600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYALAB49_RS01615	COG1254	Belongs to the acylphosphatase family
SPYALAB49_RS01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYALAB49_RS01675	COG1187	pseudouridine synthase activity
SPYALAB49_RS01690	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYALAB49_RS01695	COG0671	phosphoesterase, PA-phosphatase related
SPYALAB49_RS01700	COG1242	4 iron, 4 sulfur cluster binding
SPYALAB49_RS01705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYALAB49_RS01710	COG1253	flavin adenine dinucleotide binding
SPYALAB49_RS01715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYALAB49_RS01730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYALAB49_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYALAB49_RS01740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYALAB49_RS01745	COG1120	ATPase activity
SPYALAB49_RS01755	COG2244	polysaccharide biosynthetic process
SPYALAB49_RS01780	COG0470	DNA polymerase III
SPYALAB49_RS01805	COG1393	Belongs to the ArsC family
SPYALAB49_RS01810	COG0708	Exodeoxyribonuclease III
SPYALAB49_RS01820	COG1304	FMN binding
SPYALAB49_RS01865	COG5433	transposase activity
SPYALAB49_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
SPYALAB49_RS01910	COG0673	inositol 2-dehydrogenase activity
SPYALAB49_RS01925	COG0494	nUDIX hydrolase
SPYALAB49_RS01935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYALAB49_RS02025	COG1702	phosphate starvation-inducible protein PhoH
SPYALAB49_RS02030	COG1573	uracil-dna glycosylase
SPYALAB49_RS02040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYALAB49_RS02055	COG2274	protein secretion by the type I secretion system
SPYALAB49_RS02060	COG2274	protein secretion by the type I secretion system
SPYALAB49_RS02095	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS02100	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS02125	COG2274	protein secretion by the type I secretion system
SPYALAB49_RS02135	COG3328	transposase activity
SPYALAB49_RS02215	COG0433	COG0433 Predicted ATPase
SPYALAB49_RS02220	COG2814	Major facilitator Superfamily
SPYALAB49_RS02230	COG0557	exoribonuclease II activity
SPYALAB49_RS02260	COG0463	Glycosyl transferase, family 2
SPYALAB49_RS02270	COG0778	Nitroreductase
SPYALAB49_RS02275	COG0006	proline dipeptidase activity
SPYALAB49_RS02280	COG1609	Transcriptional regulator
SPYALAB49_RS02290	COG0438	transferase activity, transferring glycosyl groups
SPYALAB49_RS02300	COG4555	ABC transporter
SPYALAB49_RS02320	COG0183	Belongs to the thiolase family
SPYALAB49_RS02335	COG0745	RESPONSE REGULATOR receiver
SPYALAB49_RS02340	COG5002	protein histidine kinase activity
SPYALAB49_RS02345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYALAB49_RS02355	COG1196	nuclear chromosome segregation
SPYALAB49_RS02365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYALAB49_RS02475	COG0561	phosphatase activity
SPYALAB49_RS02480	COG0561	phosphatase activity
SPYALAB49_RS02485	COG0552	protein localization to endoplasmic reticulum
SPYALAB49_RS02490	COG0477	Major facilitator Superfamily
SPYALAB49_RS02495	COG3711	transcriptional antiterminator
SPYALAB49_RS02500	COG2190	(PTS) system
SPYALAB49_RS02500	COG1263	PTS System
SPYALAB49_RS02500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYALAB49_RS02510	COG3689	TIGRFAM TIGR03943 family protein
SPYALAB49_RS02515	COG0701	Predicted permease
SPYALAB49_RS02525	COG2183	response to ionizing radiation
SPYALAB49_RS02570	COG0826	peptidase U32
SPYALAB49_RS02575	COG4443	Transcriptional Coactivator p15 (PC4)
SPYALAB49_RS02625	COG0386	Belongs to the glutathione peroxidase family
SPYALAB49_RS02630	COG1164	Oligoendopeptidase f
SPYALAB49_RS02640	COG0772	Belongs to the SEDS family
SPYALAB49_RS02675	COG1078	dGTPase activity
SPYALAB49_RS02690	COG1609	Transcriptional regulator
SPYALAB49_RS02700	COG3716	PTS system mannose fructose sorbose family IID component
SPYALAB49_RS02705	COG3715	PTS system
SPYALAB49_RS02710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYALAB49_RS02725	COG1028	Short-chain dehydrogenase reductase Sdr
SPYALAB49_RS02745	COG0546	phosphoglycolate phosphatase activity
SPYALAB49_RS02750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYALAB49_RS02760	COG2884	Cell division ATP-binding protein ftsE
SPYALAB49_RS02765	COG2177	Part of the ABC transporter FtsEX involved in
SPYALAB49_RS02780	COG5433	transposase activity
SPYALAB49_RS02790	COG1199	ATP-dependent helicase activity
SPYALAB49_RS02790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYALAB49_RS02795	COG0436	Aminotransferase
SPYALAB49_RS02830	COG2188	Transcriptional regulator
SPYALAB49_RS02835	COG2222	sugar isomerase
SPYALAB49_RS02845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYALAB49_RS02850	COG0716	FMN binding
SPYALAB49_RS02860	COG0038	chloride channel
SPYALAB49_RS02930	COG1131	(ABC) transporter
SPYALAB49_RS02950	COG4708	membrane
SPYALAB49_RS02960	COG1597	lipid kinase activity
SPYALAB49_RS03045	COG0577	efflux transmembrane transporter activity
SPYALAB49_RS03055	COG2321	neutral zinc metallopeptidase
SPYALAB49_RS03070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYALAB49_RS03080	COG1970	mechanosensitive ion channel activity
SPYALAB49_RS03085	COG0358	DNA primase activity
SPYALAB49_RS03090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYALAB49_RS03095	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYALAB49_RS03140	COG1216	Glycosyl transferase, family 2
SPYALAB49_RS03195	COG1368	sulfuric ester hydrolase activity
SPYALAB49_RS03200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYALAB49_RS03220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYALAB49_RS03225	COG0285	dihydrofolate synthase activity
SPYALAB49_RS03235	COG1104	cysteine desulfurase activity
SPYALAB49_RS03260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYALAB49_RS03265	COG0583	DNA-binding transcription factor activity
SPYALAB49_RS03275	COG0564	pseudouridine synthase activity
SPYALAB49_RS03305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYALAB49_RS03310	COG1136	(ABC) transporter
SPYALAB49_RS03315	COG0577	efflux transmembrane transporter activity
SPYALAB49_RS03320	COG0584	glycerophosphoryl diester phosphodiesterase
SPYALAB49_RS03330	COG1837	Belongs to the UPF0109 family
SPYALAB49_RS03380	COG1349	DNA-binding transcription factor activity
SPYALAB49_RS03385	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYALAB49_RS03390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYALAB49_RS03390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYALAB49_RS03390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYALAB49_RS03395	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYALAB49_RS03395	COG1388	LysM domain
SPYALAB49_RS03400	COG1388	LysM domain
SPYALAB49_RS03400	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYALAB49_RS03415	COG0105	UTP biosynthetic process
SPYALAB49_RS03435	COG0488	(ABC) transporter
SPYALAB49_RS03445	COG0242	peptide deformylase activity
SPYALAB49_RS03450	COG0737	Belongs to the 5'-nucleotidase family
SPYALAB49_RS03455	COG2357	RelA SpoT domain protein
SPYALAB49_RS03460	COG0745	RESPONSE REGULATOR receiver
SPYALAB49_RS03495	COG3425	synthase
SPYALAB49_RS03505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYALAB49_RS03565	COG0583	DNA-binding transcription factor activity
SPYALAB49_RS03590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYALAB49_RS03595	COG0765	amino acid transport
SPYALAB49_RS03615	COG0187	DNA topoisomerase II activity
SPYALAB49_RS03625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYALAB49_RS03645	COG0539	negative regulation of cytoplasmic translation
SPYALAB49_RS03680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYALAB49_RS03685	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYALAB49_RS03695	COG0300	oxidoreductase activity
SPYALAB49_RS03700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYALAB49_RS03700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYALAB49_RS03715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYALAB49_RS03720	COG2384	SAM-dependent methyltransferase
SPYALAB49_RS03730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYALAB49_RS03735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYALAB49_RS03745	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYALAB49_RS03750	COG1051	belongs to the nudix hydrolase family
SPYALAB49_RS03755	COG0628	permease
SPYALAB49_RS03760	COG0457	Tetratricopeptide repeat
SPYALAB49_RS03765	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYALAB49_RS03785	COG1129	ABC transporter
SPYALAB49_RS03805	COG0488	(ABC) transporter
SPYALAB49_RS03810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYALAB49_RS03815	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYALAB49_RS03815	COG0022	dehydrogenase e1 component
SPYALAB49_RS03820	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYALAB49_RS03835	COG5492	domain, Protein
SPYALAB49_RS03840	COG0095	Lipoate-protein ligase
SPYALAB49_RS03845	COG3442	glutamine amidotransferase
SPYALAB49_RS03850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYALAB49_RS03855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYALAB49_RS03875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYALAB49_RS03885	COG0647	UMP catabolic process
SPYALAB49_RS03910	COG0105	UTP biosynthetic process
SPYALAB49_RS03915	COG5433	transposase activity
SPYALAB49_RS03955	COG3715	PTS system
SPYALAB49_RS03960	COG3716	PTS system mannose fructose sorbose family IID component
SPYALAB49_RS03965	COG2972	Histidine kinase
SPYALAB49_RS03970	COG4753	response regulator
SPYALAB49_RS03970	COG2207	Transcriptional regulator
SPYALAB49_RS03980	COG1012	belongs to the aldehyde dehydrogenase family
SPYALAB49_RS03995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYALAB49_RS04025	COG0285	dihydrofolate synthase activity
SPYALAB49_RS04060	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYALAB49_RS04065	COG1177	transmembrane transport
SPYALAB49_RS04075	COG4565	transcriptional regulatory protein
SPYALAB49_RS04080	COG3290	protein histidine kinase activity
SPYALAB49_RS04085	COG3493	citrate carrier protein
SPYALAB49_RS04100	COG5433	transposase activity
SPYALAB49_RS04115	COG0038	chloride channel
SPYALAB49_RS04125	COG0628	permease
SPYALAB49_RS04135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYALAB49_RS04150	COG1104	cysteine desulfurase activity
SPYALAB49_RS04165	COG2357	RelA SpoT domain protein
SPYALAB49_RS04175	COG0564	pseudouridine synthase activity
SPYALAB49_RS04180	COG0280	phosphate acetyltransferase
SPYALAB49_RS04185	COG4221	oxidoreductase activity
SPYALAB49_RS04200	COG1174	glycine betaine transport
SPYALAB49_RS04215	COG2233	PERMEase
SPYALAB49_RS04240	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYALAB49_RS04270	COG1132	(ABC) transporter
SPYALAB49_RS04275	COG1132	(ABC) transporter
SPYALAB49_RS04295	COG3764	Sortase (surface protein transpeptidase)
SPYALAB49_RS04300	COG0346	lactoylglutathione lyase activity
SPYALAB49_RS04315	COG1272	protein, Hemolysin III
SPYALAB49_RS04335	COG0758	DNA mediated transformation
SPYALAB49_RS04340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYALAB49_RS04345	COG5433	transposase activity
SPYALAB49_RS04365	COG0511	ligase activity, forming carbon-carbon bonds
SPYALAB49_RS04370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYALAB49_RS04385	COG2851	Citrate transporter
SPYALAB49_RS04395	COG0511	ligase activity, forming carbon-carbon bonds
SPYALAB49_RS04400	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYALAB49_RS04435	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYALAB49_RS04455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYALAB49_RS04465	COG2188	Transcriptional regulator
SPYALAB49_RS04485	COG0488	(ABC) transporter
SPYALAB49_RS04495	COG0352	thiamine-phosphate diphosphorylase activity
SPYALAB49_RS04495	COG0351	phosphomethylpyrimidine kinase
SPYALAB49_RS04500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYALAB49_RS04505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYALAB49_RS04505	COG1328	CTP reductase activity
SPYALAB49_RS04510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYALAB49_RS04540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYALAB49_RS04560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYALAB49_RS04565	COG4684	Psort location CytoplasmicMembrane, score
SPYALAB49_RS04570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYALAB49_RS04575	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYALAB49_RS04580	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYALAB49_RS04585	COG3845	ABC transporter
SPYALAB49_RS04590	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYALAB49_RS04595	COG0295	cytidine deaminase activity
SPYALAB49_RS04600	COG2813	Specifically methylates the guanine in position
SPYALAB49_RS04615	COG5002	protein histidine kinase activity
SPYALAB49_RS04620	COG0745	RESPONSE REGULATOR receiver
SPYALAB49_RS04630	COG0704	Plays a role in the regulation of phosphate uptake
SPYALAB49_RS04645	COG0581	inorganic phosphate transmembrane transporter activity
SPYALAB49_RS04650	COG0573	inorganic phosphate transmembrane transporter activity
SPYALAB49_RS04660	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYALAB49_RS04660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYALAB49_RS04665	COG0483	inositol monophosphate 1-phosphatase activity
SPYALAB49_RS04680	COG0196	riboflavin kinase activity
SPYALAB49_RS04710	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYALAB49_RS04710	COG1136	(ABC) transporter
SPYALAB49_RS04760	COG1115	amino acid carrier protein
SPYALAB49_RS04765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYALAB49_RS04775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYALAB49_RS04780	COG1126	abc transporter atp-binding protein
SPYALAB49_RS04785	COG0765	amino acid transport
SPYALAB49_RS04790	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYALAB49_RS04805	COG0469	pyruvate kinase activity
SPYALAB49_RS04820	COG1725	Transcriptional regulator
SPYALAB49_RS04825	COG1131	(ABC) transporter
SPYALAB49_RS04865	COG1388	LysM domain
SPYALAB49_RS04865	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYALAB49_RS04875	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYALAB49_RS04885	COG4824	toxin secretion phage lysis holin
SPYALAB49_RS05120	COG1396	sequence-specific DNA binding
SPYALAB49_RS05155	COG0058	SHG alpha-glucan phosphorylase activity
SPYALAB49_RS05160	COG1640	4-alpha-glucanotransferase
SPYALAB49_RS05165	COG1609	Transcriptional regulator
SPYALAB49_RS05170	COG2182	Extracellular solute-binding protein
SPYALAB49_RS05175	COG1175	transmembrane transport
SPYALAB49_RS05180	COG3833	ABC-type maltose transport systems, permease component
SPYALAB49_RS05195	COG0657	acetylesterase activity
SPYALAB49_RS05200	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYALAB49_RS05210	COG1696	Membrane protein involved in D-alanine export
SPYALAB49_RS05230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYALAB49_RS05235	COG1126	abc transporter atp-binding protein
SPYALAB49_RS05240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYALAB49_RS05250	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYALAB49_RS05260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYALAB49_RS05260	COG3711	transcriptional antiterminator
SPYALAB49_RS05270	COG2723	6-phospho-beta-galactosidase activity
SPYALAB49_RS05300	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS05305	COG0157	Belongs to the NadC ModD family
SPYALAB49_RS05320	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS05325	COG1187	pseudouridine synthase activity
SPYALAB49_RS05335	COG2814	Major facilitator Superfamily
SPYALAB49_RS05385	COG4109	DRTGG domain
SPYALAB49_RS05415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYALAB49_RS05415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYALAB49_RS05420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYALAB49_RS05425	COG1956	GAF domain-containing protein
SPYALAB49_RS05445	COG0513	Belongs to the DEAD box helicase family
SPYALAB49_RS05450	COG0726	polysaccharide deacetylase
SPYALAB49_RS05470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYALAB49_RS05475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYALAB49_RS05495	COG2801	Transposase and inactivated derivatives
SPYALAB49_RS05510	COG1476	TRANSCRIPTIONal
SPYALAB49_RS05525	COG4122	O-methyltransferase activity
SPYALAB49_RS05530	COG2223	nitrite transmembrane transporter activity
SPYALAB49_RS05545	COG1187	pseudouridine synthase activity
SPYALAB49_RS05590	COG2333	competence protein COMEC
SPYALAB49_RS05590	COG0658	competence protein
SPYALAB49_RS05595	COG1596	polysaccharide export
SPYALAB49_RS05595	COG1555	photosystem II stabilization
SPYALAB49_RS05600	COG0204	Acyl-transferase
SPYALAB49_RS05605	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYALAB49_RS05620	COG0513	Belongs to the DEAD box helicase family
SPYALAB49_RS05635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYALAB49_RS05655	COG2116	formate transmembrane transporter activity
SPYALAB49_RS05665	COG1827	regulation of RNA biosynthetic process
SPYALAB49_RS05680	COG2217	Heavy metal translocating P-type atpase
SPYALAB49_RS05815	COG3723	Recombinational DNA repair protein, rece pathway
SPYALAB49_RS05860	COG1396	sequence-specific DNA binding
SPYALAB49_RS05870	COG0582	viral genome integration into host DNA
SPYALAB49_RS05885	COG2755	lipolytic protein G-D-S-L family
SPYALAB49_RS05900	COG0497	DNA recombination
SPYALAB49_RS05905	COG1438	arginine binding
SPYALAB49_RS05910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYALAB49_RS05935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYALAB49_RS05940	COG0415	Belongs to the DNA photolyase family
SPYALAB49_RS05950	COG0765	amino acid transport
SPYALAB49_RS05955	COG4703	Protein of unknown function (DUF1797)
SPYALAB49_RS05960	COG0542	response to heat
SPYALAB49_RS05965	COG0494	nUDIX hydrolase
SPYALAB49_RS05980	COG3599	regulation of cell shape
SPYALAB49_RS05985	COG2302	S4 RNA-binding domain
SPYALAB49_RS06000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYALAB49_RS06035	COG1217	gtp-binding protein TYPA
SPYALAB49_RS06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYALAB49_RS06045	COG1940	carbohydrate kinase activity
SPYALAB49_RS06055	COG0783	Belongs to the Dps family
SPYALAB49_RS06070	COG4470	Protein conserved in bacteria
SPYALAB49_RS06075	COG1609	Transcriptional regulator
SPYALAB49_RS06080	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYALAB49_RS06090	COG0742	ribosomal rna small subunit methyltransferase
SPYALAB49_RS06100	COG0549	Belongs to the carbamate kinase family
SPYALAB49_RS06105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYALAB49_RS06110	COG1288	antiporter activity
SPYALAB49_RS06120	COG0454	-acetyltransferase
SPYALAB49_RS06125	COG2235	arginine
SPYALAB49_RS06150	COG2972	Histidine kinase
SPYALAB49_RS06165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYALAB49_RS06170	COG0785	Cytochrome C biogenesis protein
SPYALAB49_RS06180	COG0673	inositol 2-dehydrogenase activity
SPYALAB49_RS06215	COG1605	Chorismate mutase
SPYALAB49_RS06215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYALAB49_RS06235	COG2226	methyltransferase
SPYALAB49_RS06250	COG2207	Transcriptional regulator
SPYALAB49_RS06250	COG4753	response regulator
SPYALAB49_RS06255	COG2972	Histidine kinase
SPYALAB49_RS06265	COG1653	transport
SPYALAB49_RS06270	COG0395	ABC-type sugar transport system, permease component
SPYALAB49_RS06275	COG1175	transmembrane transport
SPYALAB49_RS06280	COG1940	carbohydrate kinase activity
SPYALAB49_RS06285	COG2723	6-phospho-beta-galactosidase activity
SPYALAB49_RS06290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYALAB49_RS06305	COG0383	alpha-mannosidase activity
SPYALAB49_RS06345	COG1388	LysM domain
SPYALAB49_RS06345	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYALAB49_RS06355	COG4824	toxin secretion phage lysis holin
SPYALAB49_RS06570	COG3561	AntA/AntB antirepressor
SPYALAB49_RS06675	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPYALAB49_RS06680	COG1739	Uncharacterized protein family UPF0029
SPYALAB49_RS06690	COG1098	S1 RNA binding domain
SPYALAB49_RS06700	COG2197	response regulator
SPYALAB49_RS06705	COG4585	Histidine kinase
SPYALAB49_RS06715	COG2815	serine threonine protein kinase
SPYALAB49_RS06715	COG0515	serine threonine protein kinase
SPYALAB49_RS06725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYALAB49_RS06725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYALAB49_RS06735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYALAB49_RS06755	COG0583	DNA-binding transcription factor activity
SPYALAB49_RS06760	COG0183	Belongs to the thiolase family
SPYALAB49_RS06765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYALAB49_RS06780	COG2610	gluconate transmembrane transporter activity
SPYALAB49_RS06795	COG0116	Belongs to the methyltransferase superfamily
SPYALAB49_RS06815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYALAB49_RS06820	COG3579	cysteine-type endopeptidase activity
SPYALAB49_RS06830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYALAB49_RS06835	COG1113	amino acid transport
SPYALAB49_RS06840	COG0492	ferredoxin-NADP+ reductase activity
SPYALAB49_RS06850	COG1126	abc transporter atp-binding protein
SPYALAB49_RS06860	COG0513	Belongs to the DEAD box helicase family
SPYALAB49_RS06870	COG0768	penicillin binding
SPYALAB49_RS06905	COG1131	(ABC) transporter
SPYALAB49_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYALAB49_RS06935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYALAB49_RS06970	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYALAB49_RS06975	COG0656	L-ascorbic acid biosynthetic process
SPYALAB49_RS06985	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYALAB49_RS07005	COG0561	phosphatase activity
SPYALAB49_RS07010	COG2860	membrane
SPYALAB49_RS07020	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYALAB49_RS07060	COG2217	Heavy metal translocating P-type atpase
SPYALAB49_RS07090	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYALAB49_RS07095	COG0195	Participates in both transcription termination and antitermination
SPYALAB49_RS07110	COG5433	transposase activity
SPYALAB49_RS07130	COG4473	ABC transporter
SPYALAB49_RS07135	COG1131	(ABC) transporter
SPYALAB49_RS07140	COG0537	adenosine 5'-monophosphoramidase activity
SPYALAB49_RS07150	COG1316	TRANSCRIPTIONal
SPYALAB49_RS07160	COG0802	atpase or kinase
SPYALAB49_RS07165	COG2252	PERMEase
SPYALAB49_RS07170	COG0561	phosphatase activity
SPYALAB49_RS07180	COG3715	PTS system
SPYALAB49_RS07185	COG3716	PTS system mannose fructose sorbose family IID component
SPYALAB49_RS07195	COG5433	transposase activity
SPYALAB49_RS07220	COG0439	Biotin carboxylase
SPYALAB49_RS07235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYALAB49_RS07240	COG1028	Short-chain dehydrogenase reductase Sdr
SPYALAB49_RS07245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYALAB49_RS07270	COG1024	Enoyl-CoA hydratase
SPYALAB49_RS07305	COG0588	phosphoglycerate mutase activity
SPYALAB49_RS07310	COG2261	transglycosylase associated protein
SPYALAB49_RS07340	COG5433	transposase activity
SPYALAB49_RS07345	COG0574	Belongs to the PEP-utilizing enzyme family
SPYALAB49_RS07345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYALAB49_RS07350	COG1335	isochorismatase
SPYALAB49_RS07360	COG0436	Aminotransferase
SPYALAB49_RS07370	COG0561	phosphatase activity
SPYALAB49_RS07375	COG0252	asparaginase activity
SPYALAB49_RS07390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYALAB49_RS07395	COG1129	ABC transporter
SPYALAB49_RS07410	COG1132	(ABC) transporter
SPYALAB49_RS07415	COG4988	ABC transporter
SPYALAB49_RS07420	COG1120	ATPase activity
SPYALAB49_RS07445	COG1388	LysM domain
SPYALAB49_RS07445	COG3942	CHAP domain
SPYALAB49_RS07470	COG5433	transposase activity
SPYALAB49_RS07475	COG1482	cell wall glycoprotein biosynthetic process
SPYALAB49_RS07480	COG1940	carbohydrate kinase activity
SPYALAB49_RS07490	COG2190	(PTS) system
SPYALAB49_RS07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYALAB49_RS07490	COG1263	PTS System
SPYALAB49_RS07495	COG1621	beta-fructofuranosidase activity
SPYALAB49_RS07500	COG1609	Transcriptional regulator
SPYALAB49_RS07520	COG2131	deaminase
SPYALAB49_RS07525	COG0006	proline dipeptidase activity
SPYALAB49_RS07565	COG1194	a g-specific adenine glycosylase
SPYALAB49_RS07575	COG3118	belongs to the thioredoxin family
SPYALAB49_RS07605	COG0681	Belongs to the peptidase S26 family
SPYALAB49_RS07610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYALAB49_RS07625	COG1882	Formate acetyltransferase
SPYALAB49_RS07630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYALAB49_RS07645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYALAB49_RS07650	COG2814	Major facilitator Superfamily
SPYALAB49_RS07655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYALAB49_RS07680	COG0789	Transcriptional regulator
SPYALAB49_RS07695	COG2081	HI0933 family
SPYALAB49_RS07705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYALAB49_RS07710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYALAB49_RS07730	COG0456	acetyltransferase
SPYALAB49_RS07735	COG1214	PFAM Peptidase M22, glycoprotease
SPYALAB49_RS07750	COG0174	glutamine synthetase
SPYALAB49_RS07755	COG0789	Transcriptional regulator
SPYALAB49_RS07770	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYALAB49_RS07825	COG0668	transmembrane transport
SPYALAB49_RS07835	COG4720	Psort location CytoplasmicMembrane, score
SPYALAB49_RS07840	COG0351	phosphomethylpyrimidine kinase
SPYALAB49_RS07885	COG1929	Belongs to the glycerate kinase type-1 family
SPYALAB49_RS07890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYALAB49_RS07940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYALAB49_RS07940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYALAB49_RS07945	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYALAB49_RS07995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYALAB49_RS08000	COG1476	TRANSCRIPTIONal
SPYALAB49_RS08020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYALAB49_RS08030	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYALAB49_RS08045	COG1045	serine acetyltransferase
SPYALAB49_RS08060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYALAB49_RS08065	COG3037	sugar-specific permease SgaT UlaA
SPYALAB49_RS08075	COG3711	transcriptional antiterminator
SPYALAB49_RS08105	COG1846	Transcriptional regulator
SPYALAB49_RS08125	COG4589	Belongs to the CDS family
SPYALAB49_RS08135	COG1862	Preprotein translocase
SPYALAB49_RS08145	COG1523	belongs to the glycosyl hydrolase 13 family
SPYALAB49_RS08155	COG3842	ATPase activity
SPYALAB49_RS08195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYALAB49_RS08195	COG1263	PTS System
SPYALAB49_RS08195	COG2190	(PTS) system
SPYALAB49_RS08200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYALAB49_RS08220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYALAB49_RS08225	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYALAB49_RS08230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYALAB49_RS08250	COG0601	transmembrane transport
SPYALAB49_RS08260	COG1122	ATPase activity
SPYALAB49_RS08280	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYALAB49_RS08310	COG3711	transcriptional antiterminator
SPYALAB49_RS08320	COG3942	CHAP domain
SPYALAB49_RS08320	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYALAB49_RS08325	COG2205	protein histidine kinase activity
SPYALAB49_RS08330	COG0745	RESPONSE REGULATOR receiver
SPYALAB49_RS08335	COG0577	efflux transmembrane transporter activity
SPYALAB49_RS08340	COG1136	(ABC) transporter
SPYALAB49_RS08390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYALAB49_RS08405	COG1882	Formate acetyltransferase
SPYALAB49_RS08410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYALAB49_RS08415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYALAB49_RS08420	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYALAB49_RS08425	COG2390	Transcriptional regulator
SPYALAB49_RS08430	COG1349	DNA-binding transcription factor activity
SPYALAB49_RS08435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYALAB49_RS08445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYALAB49_RS08460	COG0564	pseudouridine synthase activity
SPYALAB49_RS08490	COG0542	response to heat
SPYALAB49_RS08495	COG4463	regulation of RNA biosynthetic process
SPYALAB49_RS08510	COG0450	alkyl hydroperoxide reductase
SPYALAB49_RS08525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYALAB49_RS08535	COG3404	Formiminotransferase-cyclodeaminase
SPYALAB49_RS08550	COG0531	amino acid
SPYALAB49_RS08580	COG3590	peptidase
SPYALAB49_RS08585	COG0366	Alpha amylase catalytic
SPYALAB49_RS08590	COG1263	PTS System
SPYALAB49_RS08590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYALAB49_RS08595	COG2188	Transcriptional regulator
SPYALAB49_RS08605	COG2514	catechol 2,3-dioxygenase activity
SPYALAB49_RS08615	COG0602	queuosine metabolic process
SPYALAB49_RS08630	COG1328	CTP reductase activity
SPYALAB49_RS08655	COG1393	Belongs to the ArsC family
SPYALAB49_RS08670	COG0519	Catalyzes the synthesis of GMP from XMP
SPYALAB49_RS08725	COG5433	transposase activity
SPYALAB49_RS08825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYALAB49_RS08830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYALAB49_RS08835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYALAB49_RS08915	COG1511	domain protein
SPYALAB49_RS08935	COG5433	transposase activity
SPYALAB49_RS08945	COG0305	Participates in initiation and elongation during chromosome replication
SPYALAB49_RS08975	COG1760	l-serine dehydratase
SPYALAB49_RS08980	COG1760	l-serine dehydratase
SPYALAB49_RS08985	COG0741	lytic transglycosylase activity
SPYALAB49_RS08990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYALAB49_RS09005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYALAB49_RS09015	COG0612	Peptidase, M16
SPYALAB49_RS09055	COG0516	GMP reductase activity
SPYALAB49_RS09055	COG0517	IMP dehydrogenase activity
SPYALAB49_RS09065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYALAB49_RS09070	COG0488	(ABC) transporter
SPYALAB49_RS09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYALAB49_RS09115	COG3328	transposase activity