locus-tag	class	description
SPYOHK_RS00005	COG1475	DNA binding
SPYOHK_RS00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYOHK_RS00040	COG0488	(ABC) transporter
SPYOHK_RS00045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYOHK_RS00055	COG0516	GMP reductase activity
SPYOHK_RS00055	COG0517	IMP dehydrogenase activity
SPYOHK_RS00075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPYOHK_RS00095	COG0612	Peptidase, M16
SPYOHK_RS00105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYOHK_RS00120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYOHK_RS00125	COG0741	lytic transglycosylase activity
SPYOHK_RS00130	COG1760	l-serine dehydratase
SPYOHK_RS00135	COG1760	l-serine dehydratase
SPYOHK_RS00165	COG0305	Participates in initiation and elongation during chromosome replication
SPYOHK_RS00185	COG1511	domain protein
SPYOHK_RS00240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPYOHK_RS00260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYOHK_RS00265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYOHK_RS00270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYOHK_RS00300	COG2814	Major facilitator Superfamily
SPYOHK_RS00310	COG0519	Catalyzes the synthesis of GMP from XMP
SPYOHK_RS00325	COG1393	Belongs to the ArsC family
SPYOHK_RS00350	COG1328	CTP reductase activity
SPYOHK_RS00355	COG0673	inositol 2-dehydrogenase activity
SPYOHK_RS00365	COG0602	queuosine metabolic process
SPYOHK_RS00375	COG2514	catechol 2,3-dioxygenase activity
SPYOHK_RS00380	COG1733	regulation of RNA biosynthetic process
SPYOHK_RS00385	COG2188	Transcriptional regulator
SPYOHK_RS00390	COG1263	PTS System
SPYOHK_RS00390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYOHK_RS00395	COG0366	Alpha amylase catalytic
SPYOHK_RS00400	COG3590	peptidase
SPYOHK_RS00430	COG0531	amino acid
SPYOHK_RS00445	COG3404	Formiminotransferase-cyclodeaminase
SPYOHK_RS00455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYOHK_RS00470	COG0450	alkyl hydroperoxide reductase
SPYOHK_RS00485	COG4463	regulation of RNA biosynthetic process
SPYOHK_RS00490	COG0542	response to heat
SPYOHK_RS00520	COG0564	pseudouridine synthase activity
SPYOHK_RS00535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYOHK_RS00550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYOHK_RS00555	COG1349	DNA-binding transcription factor activity
SPYOHK_RS00560	COG2390	Transcriptional regulator
SPYOHK_RS00565	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYOHK_RS00570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYOHK_RS00575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYOHK_RS00580	COG1882	Formate acetyltransferase
SPYOHK_RS00595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYOHK_RS00660	COG1136	(ABC) transporter
SPYOHK_RS00665	COG0577	efflux transmembrane transporter activity
SPYOHK_RS00670	COG0745	RESPONSE REGULATOR receiver
SPYOHK_RS00675	COG2205	protein histidine kinase activity
SPYOHK_RS00680	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYOHK_RS00680	COG3942	CHAP domain
SPYOHK_RS00690	COG3711	transcriptional antiterminator
SPYOHK_RS00695	COG1196	nuclear chromosome segregation
SPYOHK_RS00715	COG1404	Belongs to the peptidase S8 family
SPYOHK_RS00715	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPYOHK_RS00720	COG5433	transposase activity
SPYOHK_RS00730	COG1234	tRNA 3'-trailer cleavage
SPYOHK_RS00760	COG5433	transposase activity
SPYOHK_RS00770	COG0705	Rhomboid family
SPYOHK_RS00770	COG0457	Tetratricopeptide repeat
SPYOHK_RS00790	COG1132	(ABC) transporter
SPYOHK_RS00795	COG1132	(ABC) transporter
SPYOHK_RS00805	COG0756	dUTP diphosphatase activity
SPYOHK_RS00830	COG3290	protein histidine kinase activity
SPYOHK_RS00855	COG1847	R3H domain protein
SPYOHK_RS00875	COG1175	transmembrane transport
SPYOHK_RS00880	COG0395	ABC-type sugar transport system, permease component
SPYOHK_RS00890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYOHK_RS00905	COG0084	hydrolase, TatD family'
SPYOHK_RS00930	COG1564	THIamine pyrophosphokinase
SPYOHK_RS00945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYOHK_RS00980	COG0765	amino acid transport
SPYOHK_RS01000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYOHK_RS01010	COG0719	Fe-S assembly protein
SPYOHK_RS01015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYOHK_RS01030	COG1686	Belongs to the peptidase S11 family
SPYOHK_RS01035	COG1686	Belongs to the peptidase S11 family
SPYOHK_RS01040	COG4166	transmembrane transport
SPYOHK_RS01045	COG0601	transmembrane transport
SPYOHK_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYOHK_RS01055	COG0444	Belongs to the ABC transporter superfamily
SPYOHK_RS0109265	COG1132	(ABC) transporter
SPYOHK_RS01105	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYOHK_RS01110	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYOHK_RS01115	COG1534	Rna-binding protein
SPYOHK_RS01125	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYOHK_RS01130	COG0799	negative regulation of ribosome biogenesis
SPYOHK_RS01135	COG2226	methyltransferase
SPYOHK_RS01150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYOHK_RS01155	COG1464	Belongs to the NlpA lipoprotein family
SPYOHK_RS01170	COG1114	Component of the transport system for branched-chain amino acids
SPYOHK_RS01180	COG0569	domain protein
SPYOHK_RS01185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYOHK_RS01195	COG1704	LemA family
SPYOHK_RS01210	COG0745	RESPONSE REGULATOR receiver
SPYOHK_RS01230	COG1484	DNA-dependent DNA replication
SPYOHK_RS01240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYOHK_RS01260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYOHK_RS01275	COG1254	Belongs to the acylphosphatase family
SPYOHK_RS01280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYOHK_RS01335	COG1187	pseudouridine synthase activity
SPYOHK_RS01350	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYOHK_RS01355	COG0671	phosphoesterase, PA-phosphatase related
SPYOHK_RS01360	COG1242	4 iron, 4 sulfur cluster binding
SPYOHK_RS01365	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYOHK_RS01370	COG1253	flavin adenine dinucleotide binding
SPYOHK_RS01375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYOHK_RS01390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYOHK_RS01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYOHK_RS01400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYOHK_RS01405	COG1120	ATPase activity
SPYOHK_RS01415	COG2244	polysaccharide biosynthetic process
SPYOHK_RS01435	COG5433	transposase activity
SPYOHK_RS01450	COG0470	DNA polymerase III
SPYOHK_RS01480	COG1393	Belongs to the ArsC family
SPYOHK_RS01485	COG0708	Exodeoxyribonuclease III
SPYOHK_RS01490	COG1304	FMN binding
SPYOHK_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
SPYOHK_RS01570	COG0673	inositol 2-dehydrogenase activity
SPYOHK_RS01585	COG0494	nUDIX hydrolase
SPYOHK_RS01595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYOHK_RS01655	COG2996	Protein conserved in bacteria
SPYOHK_RS01680	COG1702	phosphate starvation-inducible protein PhoH
SPYOHK_RS01685	COG1573	uracil-dna glycosylase
SPYOHK_RS01695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYOHK_RS01710	COG3328	transposase activity
SPYOHK_RS01775	COG0433	COG0433 Predicted ATPase
SPYOHK_RS01780	COG2814	Major facilitator Superfamily
SPYOHK_RS01790	COG0557	exoribonuclease II activity
SPYOHK_RS01820	COG0463	Glycosyl transferase, family 2
SPYOHK_RS01830	COG0778	Nitroreductase
SPYOHK_RS01835	COG0006	proline dipeptidase activity
SPYOHK_RS01840	COG1609	Transcriptional regulator
SPYOHK_RS01850	COG0438	transferase activity, transferring glycosyl groups
SPYOHK_RS01860	COG4555	ABC transporter
SPYOHK_RS01880	COG0183	Belongs to the thiolase family
SPYOHK_RS01895	COG0745	RESPONSE REGULATOR receiver
SPYOHK_RS01900	COG5002	protein histidine kinase activity
SPYOHK_RS01905	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYOHK_RS01915	COG1196	nuclear chromosome segregation
SPYOHK_RS01925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYOHK_RS02015	COG0561	phosphatase activity
SPYOHK_RS02020	COG0552	protein localization to endoplasmic reticulum
SPYOHK_RS02025	COG0477	Major facilitator Superfamily
SPYOHK_RS02030	COG3711	transcriptional antiterminator
SPYOHK_RS02035	COG1263	PTS System
SPYOHK_RS02035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYOHK_RS02035	COG2190	(PTS) system
SPYOHK_RS02045	COG3689	TIGRFAM TIGR03943 family protein
SPYOHK_RS02050	COG0701	Predicted permease
SPYOHK_RS02060	COG2183	response to ionizing radiation
SPYOHK_RS02105	COG0826	peptidase U32
SPYOHK_RS02110	COG4443	Transcriptional Coactivator p15 (PC4)
SPYOHK_RS02130	COG0588	phosphoglycerate mutase activity
SPYOHK_RS02160	COG0386	Belongs to the glutathione peroxidase family
SPYOHK_RS02165	COG1164	Oligoendopeptidase f
SPYOHK_RS02175	COG0772	Belongs to the SEDS family
SPYOHK_RS02210	COG1078	dGTPase activity
SPYOHK_RS02225	COG1609	Transcriptional regulator
SPYOHK_RS02235	COG3716	PTS system mannose fructose sorbose family IID component
SPYOHK_RS02240	COG3715	PTS system
SPYOHK_RS02245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYOHK_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
SPYOHK_RS02275	COG0800	Aldolase
SPYOHK_RS02280	COG0546	phosphoglycolate phosphatase activity
SPYOHK_RS02285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYOHK_RS02295	COG2884	Cell division ATP-binding protein ftsE
SPYOHK_RS02300	COG2177	Part of the ABC transporter FtsEX involved in
SPYOHK_RS02315	COG1199	ATP-dependent helicase activity
SPYOHK_RS02315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYOHK_RS02320	COG0436	Aminotransferase
SPYOHK_RS02355	COG2188	Transcriptional regulator
SPYOHK_RS02360	COG2222	sugar isomerase
SPYOHK_RS02370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYOHK_RS02375	COG0716	FMN binding
SPYOHK_RS02385	COG0038	chloride channel
SPYOHK_RS02465	COG1131	(ABC) transporter
SPYOHK_RS02485	COG4708	membrane
SPYOHK_RS02495	COG1597	lipid kinase activity
SPYOHK_RS02580	COG0577	efflux transmembrane transporter activity
SPYOHK_RS02590	COG2321	neutral zinc metallopeptidase
SPYOHK_RS02605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYOHK_RS02615	COG1970	mechanosensitive ion channel activity
SPYOHK_RS02620	COG0358	DNA primase activity
SPYOHK_RS02625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYOHK_RS02630	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYOHK_RS02675	COG1216	Glycosyl transferase, family 2
SPYOHK_RS02730	COG1368	sulfuric ester hydrolase activity
SPYOHK_RS02735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYOHK_RS02755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYOHK_RS02760	COG0285	dihydrofolate synthase activity
SPYOHK_RS02770	COG1104	cysteine desulfurase activity
SPYOHK_RS02795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYOHK_RS02800	COG0583	DNA-binding transcription factor activity
SPYOHK_RS02810	COG0564	pseudouridine synthase activity
SPYOHK_RS02840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYOHK_RS02845	COG1136	(ABC) transporter
SPYOHK_RS02850	COG0577	efflux transmembrane transporter activity
SPYOHK_RS02855	COG0584	glycerophosphoryl diester phosphodiesterase
SPYOHK_RS02865	COG1837	Belongs to the UPF0109 family
SPYOHK_RS02915	COG1349	DNA-binding transcription factor activity
SPYOHK_RS02920	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYOHK_RS02925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYOHK_RS02925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYOHK_RS02925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYOHK_RS02930	COG1388	LysM domain
SPYOHK_RS02930	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYOHK_RS02935	COG1388	LysM domain
SPYOHK_RS02935	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYOHK_RS02940	COG2801	Transposase and inactivated derivatives
SPYOHK_RS02955	COG0105	UTP biosynthetic process
SPYOHK_RS02975	COG0488	(ABC) transporter
SPYOHK_RS02985	COG0242	peptide deformylase activity
SPYOHK_RS02990	COG0737	Belongs to the 5'-nucleotidase family
SPYOHK_RS02995	COG2357	RelA SpoT domain protein
SPYOHK_RS03000	COG0745	RESPONSE REGULATOR receiver
SPYOHK_RS03040	COG3425	synthase
SPYOHK_RS03050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYOHK_RS03110	COG0583	DNA-binding transcription factor activity
SPYOHK_RS03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYOHK_RS03140	COG0765	amino acid transport
SPYOHK_RS03160	COG0187	DNA topoisomerase II activity
SPYOHK_RS03170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYOHK_RS03190	COG0539	negative regulation of cytoplasmic translation
SPYOHK_RS03225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYOHK_RS03230	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYOHK_RS03240	COG0300	oxidoreductase activity
SPYOHK_RS03245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYOHK_RS03245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYOHK_RS03260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYOHK_RS03265	COG2384	SAM-dependent methyltransferase
SPYOHK_RS03275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYOHK_RS03280	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYOHK_RS03290	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYOHK_RS03295	COG0582	viral genome integration into host DNA
SPYOHK_RS03315	COG3561	AntA/AntB antirepressor
SPYOHK_RS03555	COG1051	belongs to the nudix hydrolase family
SPYOHK_RS03560	COG0628	permease
SPYOHK_RS03565	COG0457	Tetratricopeptide repeat
SPYOHK_RS03570	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYOHK_RS03585	COG1129	ABC transporter
SPYOHK_RS03605	COG0488	(ABC) transporter
SPYOHK_RS03610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYOHK_RS03615	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYOHK_RS03615	COG0022	dehydrogenase e1 component
SPYOHK_RS03620	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYOHK_RS03630	COG5492	domain, Protein
SPYOHK_RS03635	COG0095	Lipoate-protein ligase
SPYOHK_RS03640	COG3442	glutamine amidotransferase
SPYOHK_RS03645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYOHK_RS03650	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYOHK_RS03670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYOHK_RS03680	COG0647	UMP catabolic process
SPYOHK_RS03695	COG1518	maintenance of DNA repeat elements
SPYOHK_RS03700	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPYOHK_RS03715	COG0105	UTP biosynthetic process
SPYOHK_RS03720	COG5433	transposase activity
SPYOHK_RS03760	COG3715	PTS system
SPYOHK_RS03765	COG3716	PTS system mannose fructose sorbose family IID component
SPYOHK_RS03770	COG2972	Histidine kinase
SPYOHK_RS03775	COG2207	Transcriptional regulator
SPYOHK_RS03775	COG4753	response regulator
SPYOHK_RS03785	COG1012	belongs to the aldehyde dehydrogenase family
SPYOHK_RS03800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYOHK_RS03880	COG1131	(ABC) transporter
SPYOHK_RS03895	COG1396	sequence-specific DNA binding
SPYOHK_RS03930	COG0285	dihydrofolate synthase activity
SPYOHK_RS03950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPYOHK_RS03965	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYOHK_RS03970	COG1177	transmembrane transport
SPYOHK_RS03980	COG4565	transcriptional regulatory protein
SPYOHK_RS03985	COG3290	protein histidine kinase activity
SPYOHK_RS04000	COG3700	Belongs to the class B bacterial acid phosphatase family
SPYOHK_RS04005	COG0038	chloride channel
SPYOHK_RS04015	COG0628	permease
SPYOHK_RS04025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYOHK_RS04040	COG1104	cysteine desulfurase activity
SPYOHK_RS04050	COG4116	CYTH
SPYOHK_RS04055	COG2357	RelA SpoT domain protein
SPYOHK_RS04065	COG0564	pseudouridine synthase activity
SPYOHK_RS04070	COG0280	phosphate acetyltransferase
SPYOHK_RS04075	COG4221	oxidoreductase activity
SPYOHK_RS04090	COG1174	glycine betaine transport
SPYOHK_RS04105	COG2233	PERMEase
SPYOHK_RS04130	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYOHK_RS04160	COG1132	(ABC) transporter
SPYOHK_RS04165	COG1132	(ABC) transporter
SPYOHK_RS04185	COG3764	Sortase (surface protein transpeptidase)
SPYOHK_RS04190	COG0346	lactoylglutathione lyase activity
SPYOHK_RS04205	COG1272	protein, Hemolysin III
SPYOHK_RS04225	COG0758	DNA mediated transformation
SPYOHK_RS04230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYOHK_RS04270	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYOHK_RS04290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYOHK_RS04300	COG2188	Transcriptional regulator
SPYOHK_RS04320	COG0488	(ABC) transporter
SPYOHK_RS04330	COG0352	thiamine-phosphate diphosphorylase activity
SPYOHK_RS04330	COG0351	phosphomethylpyrimidine kinase
SPYOHK_RS04335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYOHK_RS04340	COG1328	CTP reductase activity
SPYOHK_RS04340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYOHK_RS04345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYOHK_RS04375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYOHK_RS04385	COG0095	Lipoate-protein ligase
SPYOHK_RS04395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYOHK_RS04400	COG4684	Psort location CytoplasmicMembrane, score
SPYOHK_RS04405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYOHK_RS04410	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYOHK_RS04415	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYOHK_RS04420	COG3845	ABC transporter
SPYOHK_RS04425	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYOHK_RS04430	COG0295	cytidine deaminase activity
SPYOHK_RS04435	COG2813	Specifically methylates the guanine in position
SPYOHK_RS04450	COG5002	protein histidine kinase activity
SPYOHK_RS04455	COG0745	RESPONSE REGULATOR receiver
SPYOHK_RS04465	COG0704	Plays a role in the regulation of phosphate uptake
SPYOHK_RS04480	COG0581	inorganic phosphate transmembrane transporter activity
SPYOHK_RS04485	COG0573	inorganic phosphate transmembrane transporter activity
SPYOHK_RS04495	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYOHK_RS04495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYOHK_RS04500	COG0483	inositol monophosphate 1-phosphatase activity
SPYOHK_RS04515	COG0196	riboflavin kinase activity
SPYOHK_RS04545	COG1136	(ABC) transporter
SPYOHK_RS04545	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYOHK_RS04595	COG1115	amino acid carrier protein
SPYOHK_RS04600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYOHK_RS04610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYOHK_RS04615	COG1126	abc transporter atp-binding protein
SPYOHK_RS04620	COG0765	amino acid transport
SPYOHK_RS04625	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYOHK_RS04640	COG0469	pyruvate kinase activity
SPYOHK_RS04655	COG1725	Transcriptional regulator
SPYOHK_RS04660	COG1131	(ABC) transporter
SPYOHK_RS04680	COG0058	SHG alpha-glucan phosphorylase activity
SPYOHK_RS04685	COG1640	4-alpha-glucanotransferase
SPYOHK_RS04690	COG1609	Transcriptional regulator
SPYOHK_RS04695	COG2182	Extracellular solute-binding protein
SPYOHK_RS04700	COG1175	transmembrane transport
SPYOHK_RS04705	COG3833	ABC-type maltose transport systems, permease component
SPYOHK_RS04715	COG0657	acetylesterase activity
SPYOHK_RS04720	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYOHK_RS04730	COG1696	Membrane protein involved in D-alanine export
SPYOHK_RS04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYOHK_RS04755	COG1126	abc transporter atp-binding protein
SPYOHK_RS04765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYOHK_RS04775	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYOHK_RS04785	COG3711	transcriptional antiterminator
SPYOHK_RS04785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYOHK_RS04795	COG2723	6-phospho-beta-galactosidase activity
SPYOHK_RS04820	COG2801	Transposase and inactivated derivatives
SPYOHK_RS04825	COG1187	pseudouridine synthase activity
SPYOHK_RS04835	COG2814	Major facilitator Superfamily
SPYOHK_RS04870	COG1132	(ABC) transporter
SPYOHK_RS04875	COG1132	(ABC) transporter
SPYOHK_RS04875	COG2375	cellular response to nickel ion
SPYOHK_RS04880	COG1129	ABC transporter
SPYOHK_RS04885	COG2826	transposase and inactivated derivatives, IS30 family
SPYOHK_RS04930	COG0791	NLP P60 protein
SPYOHK_RS04930	COG0741	lytic transglycosylase activity
SPYOHK_RS04975	COG2946	Replication initiation factor
SPYOHK_RS04980	COG1674	ftsk spoiiie
SPYOHK_RS04995	COG1129	ABC transporter
SPYOHK_RS05010	COG1309	transcriptional regulator
SPYOHK_RS05045	COG0551	DNA topoisomerase type I activity
SPYOHK_RS05045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYOHK_RS05070	COG3344	reverse transcriptase
SPYOHK_RS05115	COG1484	DNA-dependent DNA replication
SPYOHK_RS05160	COG4109	DRTGG domain
SPYOHK_RS05190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYOHK_RS05190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYOHK_RS05195	COG5433	transposase activity
SPYOHK_RS05200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYOHK_RS05205	COG1956	GAF domain-containing protein
SPYOHK_RS05225	COG0513	Belongs to the DEAD box helicase family
SPYOHK_RS05230	COG0726	polysaccharide deacetylase
SPYOHK_RS05250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYOHK_RS05255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYOHK_RS05260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYOHK_RS05275	COG2801	Transposase and inactivated derivatives
SPYOHK_RS05280	COG2801	Transposase and inactivated derivatives
SPYOHK_RS05295	COG1476	TRANSCRIPTIONal
SPYOHK_RS05310	COG4122	O-methyltransferase activity
SPYOHK_RS05315	COG2223	nitrite transmembrane transporter activity
SPYOHK_RS05330	COG1187	pseudouridine synthase activity
SPYOHK_RS05370	COG2333	competence protein COMEC
SPYOHK_RS05370	COG0658	competence protein
SPYOHK_RS05375	COG1555	photosystem II stabilization
SPYOHK_RS05375	COG1596	polysaccharide export
SPYOHK_RS05380	COG0204	Acyl-transferase
SPYOHK_RS05385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPYOHK_RS05400	COG0513	Belongs to the DEAD box helicase family
SPYOHK_RS05415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYOHK_RS05430	COG2116	formate transmembrane transporter activity
SPYOHK_RS05440	COG1827	regulation of RNA biosynthetic process
SPYOHK_RS05455	COG2217	Heavy metal translocating P-type atpase
SPYOHK_RS05470	COG2755	lipolytic protein G-D-S-L family
SPYOHK_RS05485	COG0497	DNA recombination
SPYOHK_RS05490	COG1438	arginine binding
SPYOHK_RS05495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYOHK_RS05520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYOHK_RS05525	COG0415	Belongs to the DNA photolyase family
SPYOHK_RS05535	COG0765	amino acid transport
SPYOHK_RS05540	COG4703	Protein of unknown function (DUF1797)
SPYOHK_RS05545	COG0542	response to heat
SPYOHK_RS05550	COG0494	nUDIX hydrolase
SPYOHK_RS05565	COG3599	regulation of cell shape
SPYOHK_RS05570	COG2302	S4 RNA-binding domain
SPYOHK_RS05585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYOHK_RS05620	COG1217	gtp-binding protein TYPA
SPYOHK_RS05625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYOHK_RS05630	COG1940	carbohydrate kinase activity
SPYOHK_RS05640	COG0783	Belongs to the Dps family
SPYOHK_RS05655	COG4470	Protein conserved in bacteria
SPYOHK_RS05660	COG1609	Transcriptional regulator
SPYOHK_RS05665	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYOHK_RS05675	COG0742	ribosomal rna small subunit methyltransferase
SPYOHK_RS05685	COG0549	Belongs to the carbamate kinase family
SPYOHK_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYOHK_RS05695	COG1288	antiporter activity
SPYOHK_RS05710	COG2235	arginine
SPYOHK_RS05735	COG2972	Histidine kinase
SPYOHK_RS05750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYOHK_RS05755	COG0785	Cytochrome C biogenesis protein
SPYOHK_RS05760	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPYOHK_RS05765	COG1518	maintenance of DNA repeat elements
SPYOHK_RS05825	COG1605	Chorismate mutase
SPYOHK_RS05825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYOHK_RS05845	COG2226	methyltransferase
SPYOHK_RS05855	COG3250	beta-galactosidase activity
SPYOHK_RS05860	COG2207	Transcriptional regulator
SPYOHK_RS05860	COG4753	response regulator
SPYOHK_RS05865	COG2972	Histidine kinase
SPYOHK_RS05875	COG1653	transport
SPYOHK_RS05880	COG0395	ABC-type sugar transport system, permease component
SPYOHK_RS05885	COG1175	transmembrane transport
SPYOHK_RS05895	COG2723	6-phospho-beta-galactosidase activity
SPYOHK_RS05900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYOHK_RS05915	COG0383	alpha-mannosidase activity
SPYOHK_RS06010	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPYOHK_RS06015	COG1739	Uncharacterized protein family UPF0029
SPYOHK_RS06025	COG1098	S1 RNA binding domain
SPYOHK_RS06035	COG2197	response regulator
SPYOHK_RS06040	COG4585	Histidine kinase
SPYOHK_RS06050	COG0515	serine threonine protein kinase
SPYOHK_RS06050	COG2815	serine threonine protein kinase
SPYOHK_RS06060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYOHK_RS06060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYOHK_RS06070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYOHK_RS06090	COG0583	DNA-binding transcription factor activity
SPYOHK_RS06095	COG0183	Belongs to the thiolase family
SPYOHK_RS06100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYOHK_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
SPYOHK_RS06125	COG0116	Belongs to the methyltransferase superfamily
SPYOHK_RS06145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYOHK_RS06150	COG3579	cysteine-type endopeptidase activity
SPYOHK_RS06160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYOHK_RS06165	COG1113	amino acid transport
SPYOHK_RS06170	COG0492	ferredoxin-NADP+ reductase activity
SPYOHK_RS06180	COG1126	abc transporter atp-binding protein
SPYOHK_RS06190	COG0513	Belongs to the DEAD box helicase family
SPYOHK_RS06200	COG0768	penicillin binding
SPYOHK_RS06235	COG1131	(ABC) transporter
SPYOHK_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYOHK_RS06265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYOHK_RS06295	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYOHK_RS06300	COG0656	L-ascorbic acid biosynthetic process
SPYOHK_RS06310	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYOHK_RS06330	COG0561	phosphatase activity
SPYOHK_RS06335	COG2860	membrane
SPYOHK_RS06345	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYOHK_RS06385	COG2217	Heavy metal translocating P-type atpase
SPYOHK_RS06415	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYOHK_RS06420	COG0195	Participates in both transcription termination and antitermination
SPYOHK_RS06440	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYOHK_RS06560	COG1783	phage Terminase large subunit
SPYOHK_RS06685	COG4974	Belongs to the 'phage' integrase family
SPYOHK_RS06705	COG4473	ABC transporter
SPYOHK_RS06710	COG1131	(ABC) transporter
SPYOHK_RS06715	COG0537	adenosine 5'-monophosphoramidase activity
SPYOHK_RS06725	COG1316	TRANSCRIPTIONal
SPYOHK_RS06735	COG0802	atpase or kinase
SPYOHK_RS06740	COG2252	PERMEase
SPYOHK_RS06745	COG0561	phosphatase activity
SPYOHK_RS06755	COG3715	PTS system
SPYOHK_RS06760	COG3716	PTS system mannose fructose sorbose family IID component
SPYOHK_RS06785	COG0439	Biotin carboxylase
SPYOHK_RS06800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYOHK_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
SPYOHK_RS06810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYOHK_RS06835	COG1024	Enoyl-CoA hydratase
SPYOHK_RS06840	COG0484	heat shock protein binding
SPYOHK_RS06870	COG0588	phosphoglycerate mutase activity
SPYOHK_RS06875	COG2261	transglycosylase associated protein
SPYOHK_RS06895	COG0574	Belongs to the PEP-utilizing enzyme family
SPYOHK_RS06895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYOHK_RS06900	COG1335	isochorismatase
SPYOHK_RS06910	COG0436	Aminotransferase
SPYOHK_RS06920	COG0561	phosphatase activity
SPYOHK_RS06925	COG0252	asparaginase activity
SPYOHK_RS06940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYOHK_RS06945	COG1129	ABC transporter
SPYOHK_RS06960	COG1132	(ABC) transporter
SPYOHK_RS06965	COG4988	ABC transporter
SPYOHK_RS06970	COG1120	ATPase activity
SPYOHK_RS06995	COG3942	CHAP domain
SPYOHK_RS06995	COG1388	LysM domain
SPYOHK_RS07020	COG5433	transposase activity
SPYOHK_RS07025	COG1482	cell wall glycoprotein biosynthetic process
SPYOHK_RS07030	COG1940	carbohydrate kinase activity
SPYOHK_RS07040	COG1263	PTS System
SPYOHK_RS07040	COG2190	(PTS) system
SPYOHK_RS07040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYOHK_RS07045	COG1621	beta-fructofuranosidase activity
SPYOHK_RS07050	COG1609	Transcriptional regulator
SPYOHK_RS07070	COG2131	deaminase
SPYOHK_RS07075	COG0006	proline dipeptidase activity
SPYOHK_RS07110	COG3177	Filamentation induced by cAMP protein fic
SPYOHK_RS07115	COG1388	LysM domain
SPYOHK_RS07115	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYOHK_RS07125	COG4824	toxin secretion phage lysis holin
SPYOHK_RS07295	COG3723	Recombinational DNA repair protein, rece pathway
SPYOHK_RS07315	COG3935	DnaD domain protein
SPYOHK_RS07345	COG3561	AntA/AntB antirepressor
SPYOHK_RS07430	COG1194	a g-specific adenine glycosylase
SPYOHK_RS07440	COG3118	belongs to the thioredoxin family
SPYOHK_RS07470	COG0681	Belongs to the peptidase S26 family
SPYOHK_RS07475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYOHK_RS07490	COG1882	Formate acetyltransferase
SPYOHK_RS07495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYOHK_RS07510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYOHK_RS07515	COG2814	Major facilitator Superfamily
SPYOHK_RS07520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYOHK_RS07545	COG0789	Transcriptional regulator
SPYOHK_RS07560	COG2081	HI0933 family
SPYOHK_RS07570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYOHK_RS07575	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYOHK_RS07595	COG0456	acetyltransferase
SPYOHK_RS07600	COG1214	PFAM Peptidase M22, glycoprotease
SPYOHK_RS07615	COG0174	glutamine synthetase
SPYOHK_RS07620	COG0789	Transcriptional regulator
SPYOHK_RS07635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYOHK_RS07690	COG0668	transmembrane transport
SPYOHK_RS07700	COG4720	Psort location CytoplasmicMembrane, score
SPYOHK_RS07705	COG0351	phosphomethylpyrimidine kinase
SPYOHK_RS07750	COG1929	Belongs to the glycerate kinase type-1 family
SPYOHK_RS07755	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYOHK_RS07785	COG0577	efflux transmembrane transporter activity
SPYOHK_RS07790	COG1136	(ABC) transporter
SPYOHK_RS07810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYOHK_RS07810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYOHK_RS07815	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYOHK_RS07865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYOHK_RS07870	COG1476	TRANSCRIPTIONal
SPYOHK_RS07890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYOHK_RS07900	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYOHK_RS07915	COG1045	serine acetyltransferase
SPYOHK_RS07930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYOHK_RS07945	COG3711	transcriptional antiterminator
SPYOHK_RS07975	COG1846	Transcriptional regulator
SPYOHK_RS07995	COG4589	Belongs to the CDS family
SPYOHK_RS08005	COG1862	Preprotein translocase
SPYOHK_RS08015	COG1523	belongs to the glycosyl hydrolase 13 family
SPYOHK_RS08025	COG3842	ATPase activity
SPYOHK_RS08065	COG1263	PTS System
SPYOHK_RS08065	COG2190	(PTS) system
SPYOHK_RS08065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYOHK_RS08070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYOHK_RS08100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYOHK_RS08105	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYOHK_RS08110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYOHK_RS08145	COG0601	transmembrane transport
SPYOHK_RS08175	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYOHK_RS08185	COG5433	transposase activity
SPYOHK_RS08190	COG1268	BioY protein
SPYOHK_RS08210	COG2801	Transposase and inactivated derivatives
SPYOHK_RS08215	COG0157	Belongs to the NadC ModD family
SPYOHK_RS08230	COG2801	Transposase and inactivated derivatives
SPYOHK_RS08235	COG2801	Transposase and inactivated derivatives
SPYOHK_RS08240	COG1475	DNA binding
SPYOHK_RS08245	COG3969	phosphoadenosine phosphosulfate
SPYOHK_RS08265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYOHK_RS08265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYOHK_RS08275	COG4175	Glycine betaine
SPYOHK_RS08275	COG3448	diguanylate cyclase activity
SPYOHK_RS08295	COG3623	hexulose-6-phosphate isomerase
SPYOHK_RS08325	COG0626	cystathionine gamma-synthase activity
SPYOHK_RS08360	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYOHK_RS08395	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYOHK_RS08400	COG1527	subunit (C
SPYOHK_RS08410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYOHK_RS08415	COG1269	ATP hydrolysis coupled proton transport
SPYOHK_RS08430	COG0251	oxidation-reduction process
SPYOHK_RS08445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYOHK_RS08460	COG2031	fatty acid transporter
SPYOHK_RS08485	COG4509	Sortase family
SPYOHK_RS08520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYOHK_RS08525	COG1428	Deoxynucleoside kinase
SPYOHK_RS08535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYOHK_RS08540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYOHK_RS08550	COG1363	Peptidase, m42
SPYOHK_RS08555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYOHK_RS08595	COG4537	Required for transformation and DNA binding
SPYOHK_RS08600	COG1459	type II secretion system
SPYOHK_RS08605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYOHK_RS08625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYOHK_RS08640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYOHK_RS08645	COG1121	(ABC) transporter
SPYOHK_RS08780	COG0201	protein transport
SPYOHK_RS08890	COG0534	Mate efflux family protein
SPYOHK_RS08895	COG1064	alcohol dehydrogenase
SPYOHK_RS08900	COG1012	belongs to the aldehyde dehydrogenase family
SPYOHK_RS08900	COG1454	alcohol dehydrogenase
SPYOHK_RS08915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYOHK_RS08930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYOHK_RS08945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYOHK_RS08965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYOHK_RS08980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYOHK_RS08990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYOHK_RS09010	COG3942	CHAP domain
SPYOHK_RS09185	COG0531	amino acid
SPYOHK_RS09190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYOHK_RS09215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYOHK_RS09220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYOHK_RS09230	COG0012	GTP binding
SPYOHK_RS09240	COG0592	DNA-directed DNA polymerase activity