locus-tag	class	description
SpyM6JRS4_RS00010	COG0592	DNA-directed DNA polymerase activity
SpyM6JRS4_RS00020	COG0012	GTP binding
SpyM6JRS4_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SpyM6JRS4_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SpyM6JRS4_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SpyM6JRS4_RS00070	COG0531	amino acid
SpyM6JRS4_RS00245	COG3942	CHAP domain
SpyM6JRS4_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SpyM6JRS4_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SpyM6JRS4_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SpyM6JRS4_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SpyM6JRS4_RS00315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SpyM6JRS4_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SpyM6JRS4_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SpyM6JRS4_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
SpyM6JRS4_RS00355	COG1454	alcohol dehydrogenase
SpyM6JRS4_RS00360	COG1064	alcohol dehydrogenase
SpyM6JRS4_RS00365	COG0534	Mate efflux family protein
SpyM6JRS4_RS00475	COG0201	protein transport
SpyM6JRS4_RS00615	COG1121	(ABC) transporter
SpyM6JRS4_RS00620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SpyM6JRS4_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SpyM6JRS4_RS00655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SpyM6JRS4_RS00660	COG1459	type II secretion system
SpyM6JRS4_RS00665	COG4537	Required for transformation and DNA binding
SpyM6JRS4_RS00705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SpyM6JRS4_RS00710	COG1363	Peptidase, m42
SpyM6JRS4_RS00720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SpyM6JRS4_RS00725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SpyM6JRS4_RS00740	COG1428	Deoxynucleoside kinase
SpyM6JRS4_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SpyM6JRS4_RS00785	COG2031	fatty acid transporter
SpyM6JRS4_RS00800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SpyM6JRS4_RS00815	COG0251	oxidation-reduction process
SpyM6JRS4_RS00830	COG1269	ATP hydrolysis coupled proton transport
SpyM6JRS4_RS00835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SpyM6JRS4_RS00845	COG1527	subunit (C
SpyM6JRS4_RS00850	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SpyM6JRS4_RS00885	COG1744	ABC transporter substrate-binding protein PnrA-like
SpyM6JRS4_RS00920	COG0626	cystathionine gamma-synthase activity
SpyM6JRS4_RS00950	COG3623	hexulose-6-phosphate isomerase
SpyM6JRS4_RS00970	COG3448	diguanylate cyclase activity
SpyM6JRS4_RS00970	COG4175	Glycine betaine
SpyM6JRS4_RS00980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SpyM6JRS4_RS00980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SpyM6JRS4_RS01005	COG1268	BioY protein
SpyM6JRS4_RS01010	COG1234	tRNA 3'-trailer cleavage
SpyM6JRS4_RS01040	COG0457	Tetratricopeptide repeat
SpyM6JRS4_RS01040	COG0705	Rhomboid family
SpyM6JRS4_RS01060	COG1132	(ABC) transporter
SpyM6JRS4_RS01065	COG1132	(ABC) transporter
SpyM6JRS4_RS01075	COG0756	dUTP diphosphatase activity
SpyM6JRS4_RS01100	COG3290	protein histidine kinase activity
SpyM6JRS4_RS01125	COG1847	R3H domain protein
SpyM6JRS4_RS01145	COG1175	transmembrane transport
SpyM6JRS4_RS01150	COG0395	ABC-type sugar transport system, permease component
SpyM6JRS4_RS01160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SpyM6JRS4_RS01175	COG0084	hydrolase, TatD family'
SpyM6JRS4_RS01200	COG1564	THIamine pyrophosphokinase
SpyM6JRS4_RS01215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SpyM6JRS4_RS01250	COG0765	amino acid transport
SpyM6JRS4_RS01270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SpyM6JRS4_RS01280	COG0719	Fe-S assembly protein
SpyM6JRS4_RS01285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SpyM6JRS4_RS01300	COG1686	Belongs to the peptidase S11 family
SpyM6JRS4_RS01305	COG1686	Belongs to the peptidase S11 family
SpyM6JRS4_RS01310	COG4166	transmembrane transport
SpyM6JRS4_RS01315	COG0601	transmembrane transport
SpyM6JRS4_RS01320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SpyM6JRS4_RS01325	COG0444	Belongs to the ABC transporter superfamily
SpyM6JRS4_RS01375	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SpyM6JRS4_RS01380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SpyM6JRS4_RS01385	COG1534	Rna-binding protein
SpyM6JRS4_RS01395	COG1713	HD superfamily hydrolase involved in NAD metabolism
SpyM6JRS4_RS01400	COG0799	negative regulation of ribosome biogenesis
SpyM6JRS4_RS01405	COG2226	methyltransferase
SpyM6JRS4_RS01420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SpyM6JRS4_RS01425	COG1464	Belongs to the NlpA lipoprotein family
SpyM6JRS4_RS01440	COG1114	Component of the transport system for branched-chain amino acids
SpyM6JRS4_RS01450	COG0569	domain protein
SpyM6JRS4_RS01455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SpyM6JRS4_RS01465	COG1704	LemA family
SpyM6JRS4_RS01480	COG0745	RESPONSE REGULATOR receiver
SpyM6JRS4_RS01500	COG1484	DNA-dependent DNA replication
SpyM6JRS4_RS01510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SpyM6JRS4_RS01530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SpyM6JRS4_RS01545	COG1254	Belongs to the acylphosphatase family
SpyM6JRS4_RS01550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SpyM6JRS4_RS01605	COG1187	pseudouridine synthase activity
SpyM6JRS4_RS01620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SpyM6JRS4_RS01625	COG0671	phosphoesterase, PA-phosphatase related
SpyM6JRS4_RS01630	COG1242	4 iron, 4 sulfur cluster binding
SpyM6JRS4_RS01635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SpyM6JRS4_RS01640	COG1253	flavin adenine dinucleotide binding
SpyM6JRS4_RS01645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SpyM6JRS4_RS01660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SpyM6JRS4_RS01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SpyM6JRS4_RS01670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SpyM6JRS4_RS01675	COG1120	ATPase activity
SpyM6JRS4_RS01685	COG2244	polysaccharide biosynthetic process
SpyM6JRS4_RS01710	COG0470	DNA polymerase III
SpyM6JRS4_RS01745	COG1393	Belongs to the ArsC family
SpyM6JRS4_RS01750	COG0708	Exodeoxyribonuclease III
SpyM6JRS4_RS01760	COG1304	FMN binding
SpyM6JRS4_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
SpyM6JRS4_RS01825	COG0673	inositol 2-dehydrogenase activity
SpyM6JRS4_RS01840	COG0494	nUDIX hydrolase
SpyM6JRS4_RS01850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SpyM6JRS4_RS01960	COG1702	phosphate starvation-inducible protein PhoH
SpyM6JRS4_RS01965	COG1573	uracil-dna glycosylase
SpyM6JRS4_RS01975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SpyM6JRS4_RS02000	COG3328	transposase activity
SpyM6JRS4_RS02005	COG3328	transposase activity
SpyM6JRS4_RS02080	COG2814	Major facilitator Superfamily
SpyM6JRS4_RS02090	COG0557	exoribonuclease II activity
SpyM6JRS4_RS02120	COG0463	Glycosyl transferase, family 2
SpyM6JRS4_RS02130	COG0778	Nitroreductase
SpyM6JRS4_RS02135	COG0006	proline dipeptidase activity
SpyM6JRS4_RS02140	COG1609	Transcriptional regulator
SpyM6JRS4_RS02150	COG0438	transferase activity, transferring glycosyl groups
SpyM6JRS4_RS02160	COG4555	ABC transporter
SpyM6JRS4_RS02175	COG2376	Dihydroxyacetone kinase
SpyM6JRS4_RS02185	COG2376	Dihydroxyacetone kinase
SpyM6JRS4_RS02190	COG1461	Dihydroxyacetone kinase
SpyM6JRS4_RS02195	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SpyM6JRS4_RS02200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SpyM6JRS4_RS02210	COG0183	Belongs to the thiolase family
SpyM6JRS4_RS02225	COG0745	RESPONSE REGULATOR receiver
SpyM6JRS4_RS02230	COG5002	protein histidine kinase activity
SpyM6JRS4_RS02235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SpyM6JRS4_RS02245	COG1196	nuclear chromosome segregation
SpyM6JRS4_RS02255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SpyM6JRS4_RS02335	COG4695	Portal protein
SpyM6JRS4_RS02345	COG0561	phosphatase activity
SpyM6JRS4_RS02350	COG0561	phosphatase activity
SpyM6JRS4_RS02355	COG0552	protein localization to endoplasmic reticulum
SpyM6JRS4_RS02360	COG0477	Major facilitator Superfamily
SpyM6JRS4_RS02370	COG2190	(PTS) system
SpyM6JRS4_RS02370	COG1263	PTS System
SpyM6JRS4_RS02370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SpyM6JRS4_RS02380	COG3689	TIGRFAM TIGR03943 family protein
SpyM6JRS4_RS02385	COG0701	Predicted permease
SpyM6JRS4_RS02395	COG2183	response to ionizing radiation
SpyM6JRS4_RS02440	COG0826	peptidase U32
SpyM6JRS4_RS02445	COG4443	Transcriptional Coactivator p15 (PC4)
SpyM6JRS4_RS02495	COG0386	Belongs to the glutathione peroxidase family
SpyM6JRS4_RS02500	COG1164	Oligoendopeptidase f
SpyM6JRS4_RS02510	COG0772	Belongs to the SEDS family
SpyM6JRS4_RS02545	COG1078	dGTPase activity
SpyM6JRS4_RS02560	COG1609	Transcriptional regulator
SpyM6JRS4_RS02570	COG3716	PTS system mannose fructose sorbose family IID component
SpyM6JRS4_RS02575	COG3715	PTS system
SpyM6JRS4_RS02580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SpyM6JRS4_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
SpyM6JRS4_RS02610	COG0800	Aldolase
SpyM6JRS4_RS02615	COG0546	phosphoglycolate phosphatase activity
SpyM6JRS4_RS02620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SpyM6JRS4_RS02630	COG2884	Cell division ATP-binding protein ftsE
SpyM6JRS4_RS02635	COG2177	Part of the ABC transporter FtsEX involved in
SpyM6JRS4_RS02650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SpyM6JRS4_RS02650	COG1199	ATP-dependent helicase activity
SpyM6JRS4_RS02655	COG0436	Aminotransferase
SpyM6JRS4_RS02690	COG2188	Transcriptional regulator
SpyM6JRS4_RS02695	COG2222	sugar isomerase
SpyM6JRS4_RS02705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SpyM6JRS4_RS02710	COG0716	FMN binding
SpyM6JRS4_RS02720	COG0038	chloride channel
SpyM6JRS4_RS02790	COG1131	(ABC) transporter
SpyM6JRS4_RS02810	COG4708	membrane
SpyM6JRS4_RS02820	COG1597	lipid kinase activity
SpyM6JRS4_RS02905	COG0577	efflux transmembrane transporter activity
SpyM6JRS4_RS02915	COG2321	neutral zinc metallopeptidase
SpyM6JRS4_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SpyM6JRS4_RS02940	COG1970	mechanosensitive ion channel activity
SpyM6JRS4_RS02945	COG0358	DNA primase activity
SpyM6JRS4_RS02950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SpyM6JRS4_RS02955	COG2151	metal-sulfur cluster biosynthetic enzyme
SpyM6JRS4_RS03000	COG1216	Glycosyl transferase, family 2
SpyM6JRS4_RS03055	COG1368	sulfuric ester hydrolase activity
SpyM6JRS4_RS03060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SpyM6JRS4_RS03080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SpyM6JRS4_RS03085	COG0285	dihydrofolate synthase activity
SpyM6JRS4_RS03095	COG1104	cysteine desulfurase activity
SpyM6JRS4_RS03125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SpyM6JRS4_RS03130	COG0583	DNA-binding transcription factor activity
SpyM6JRS4_RS03140	COG0564	pseudouridine synthase activity
SpyM6JRS4_RS03170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SpyM6JRS4_RS03175	COG1136	(ABC) transporter
SpyM6JRS4_RS03180	COG0577	efflux transmembrane transporter activity
SpyM6JRS4_RS03185	COG0584	glycerophosphoryl diester phosphodiesterase
SpyM6JRS4_RS03195	COG1837	Belongs to the UPF0109 family
SpyM6JRS4_RS03245	COG1349	DNA-binding transcription factor activity
SpyM6JRS4_RS03250	COG1105	Belongs to the carbohydrate kinase PfkB family
SpyM6JRS4_RS03255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SpyM6JRS4_RS03255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SpyM6JRS4_RS03255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SpyM6JRS4_RS03260	COG1388	LysM domain
SpyM6JRS4_RS03260	COG1705	Flagellar rod assembly protein muramidase FlgJ
SpyM6JRS4_RS03265	COG1388	LysM domain
SpyM6JRS4_RS03265	COG1705	Flagellar rod assembly protein muramidase FlgJ
SpyM6JRS4_RS03285	COG0105	UTP biosynthetic process
SpyM6JRS4_RS03305	COG0488	(ABC) transporter
SpyM6JRS4_RS03315	COG0242	peptide deformylase activity
SpyM6JRS4_RS03320	COG0737	Belongs to the 5'-nucleotidase family
SpyM6JRS4_RS03325	COG2357	RelA SpoT domain protein
SpyM6JRS4_RS03330	COG0745	RESPONSE REGULATOR receiver
SpyM6JRS4_RS03365	COG3425	synthase
SpyM6JRS4_RS03375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SpyM6JRS4_RS03420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SpyM6JRS4_RS03435	COG0583	DNA-binding transcription factor activity
SpyM6JRS4_RS03460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SpyM6JRS4_RS03465	COG0765	amino acid transport
SpyM6JRS4_RS03485	COG0187	DNA topoisomerase II activity
SpyM6JRS4_RS03495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SpyM6JRS4_RS03515	COG0539	negative regulation of cytoplasmic translation
SpyM6JRS4_RS03530	COG2801	Transposase and inactivated derivatives
SpyM6JRS4_RS03605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SpyM6JRS4_RS03610	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SpyM6JRS4_RS03620	COG0300	oxidoreductase activity
SpyM6JRS4_RS03625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SpyM6JRS4_RS03625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SpyM6JRS4_RS03640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SpyM6JRS4_RS03645	COG2384	SAM-dependent methyltransferase
SpyM6JRS4_RS03655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SpyM6JRS4_RS03660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SpyM6JRS4_RS03670	COG1088	dTDP-glucose 4,6-dehydratase activity
SpyM6JRS4_RS03675	COG1051	belongs to the nudix hydrolase family
SpyM6JRS4_RS03680	COG0628	permease
SpyM6JRS4_RS03690	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SpyM6JRS4_RS03705	COG1129	ABC transporter
SpyM6JRS4_RS03725	COG0488	(ABC) transporter
SpyM6JRS4_RS03730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SpyM6JRS4_RS03735	COG0022	dehydrogenase e1 component
SpyM6JRS4_RS03735	COG0508	dehydrogenase complex catalyzes the overall conversion of
SpyM6JRS4_RS03740	COG0508	dehydrogenase complex catalyzes the overall conversion of
SpyM6JRS4_RS03755	COG5492	domain, Protein
SpyM6JRS4_RS03760	COG0095	Lipoate-protein ligase
SpyM6JRS4_RS03765	COG3442	glutamine amidotransferase
SpyM6JRS4_RS03770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SpyM6JRS4_RS03775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SpyM6JRS4_RS03795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SpyM6JRS4_RS03805	COG0647	UMP catabolic process
SpyM6JRS4_RS03850	COG3715	PTS system
SpyM6JRS4_RS03855	COG3716	PTS system mannose fructose sorbose family IID component
SpyM6JRS4_RS03860	COG2972	Histidine kinase
SpyM6JRS4_RS03865	COG4753	response regulator
SpyM6JRS4_RS03865	COG2207	Transcriptional regulator
SpyM6JRS4_RS03875	COG1012	belongs to the aldehyde dehydrogenase family
SpyM6JRS4_RS03890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SpyM6JRS4_RS03910	COG4109	DRTGG domain
SpyM6JRS4_RS03960	COG2814	Major facilitator Superfamily
SpyM6JRS4_RS03970	COG1187	pseudouridine synthase activity
SpyM6JRS4_RS03985	COG0157	Belongs to the NadC ModD family
SpyM6JRS4_RS03990	COG2801	Transposase and inactivated derivatives
SpyM6JRS4_RS04015	COG2723	6-phospho-beta-galactosidase activity
SpyM6JRS4_RS04025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SpyM6JRS4_RS04025	COG3711	transcriptional antiterminator
SpyM6JRS4_RS04035	COG1447	Phosphotransferase system cellobiose-specific component IIA
SpyM6JRS4_RS04045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SpyM6JRS4_RS04050	COG1126	abc transporter atp-binding protein
SpyM6JRS4_RS04055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SpyM6JRS4_RS04075	COG1696	Membrane protein involved in D-alanine export
SpyM6JRS4_RS04085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SpyM6JRS4_RS04090	COG0657	acetylesterase activity
SpyM6JRS4_RS04105	COG3833	ABC-type maltose transport systems, permease component
SpyM6JRS4_RS04110	COG1175	transmembrane transport
SpyM6JRS4_RS04115	COG2182	Extracellular solute-binding protein
SpyM6JRS4_RS04120	COG1609	Transcriptional regulator
SpyM6JRS4_RS04125	COG1640	4-alpha-glucanotransferase
SpyM6JRS4_RS04130	COG0058	SHG alpha-glucan phosphorylase activity
SpyM6JRS4_RS04150	COG1131	(ABC) transporter
SpyM6JRS4_RS04155	COG1725	Transcriptional regulator
SpyM6JRS4_RS04170	COG0469	pyruvate kinase activity
SpyM6JRS4_RS04190	COG2213	PTS system mannitol-specific
SpyM6JRS4_RS04195	COG3711	transcriptional antiterminator
SpyM6JRS4_RS04200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SpyM6JRS4_RS04205	COG0246	Mannitol dehydrogenase
SpyM6JRS4_RS04220	COG2824	Alkylphosphonate utilization operon protein PhnA
SpyM6JRS4_RS04225	COG0765	amino acid transport
SpyM6JRS4_RS04230	COG1126	abc transporter atp-binding protein
SpyM6JRS4_RS04235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SpyM6JRS4_RS04245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SpyM6JRS4_RS04250	COG1115	amino acid carrier protein
SpyM6JRS4_RS04300	COG1136	(ABC) transporter
SpyM6JRS4_RS04300	COG4591	ABC-type transport system involved in lipoprotein release permease component
SpyM6JRS4_RS04330	COG0196	riboflavin kinase activity
SpyM6JRS4_RS04345	COG0483	inositol monophosphate 1-phosphatase activity
SpyM6JRS4_RS04350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SpyM6JRS4_RS04350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SpyM6JRS4_RS04360	COG0573	inorganic phosphate transmembrane transporter activity
SpyM6JRS4_RS04365	COG0581	inorganic phosphate transmembrane transporter activity
SpyM6JRS4_RS04380	COG0704	Plays a role in the regulation of phosphate uptake
SpyM6JRS4_RS04390	COG0745	RESPONSE REGULATOR receiver
SpyM6JRS4_RS04395	COG5002	protein histidine kinase activity
SpyM6JRS4_RS04410	COG2813	Specifically methylates the guanine in position
SpyM6JRS4_RS04415	COG0295	cytidine deaminase activity
SpyM6JRS4_RS04420	COG1744	ABC transporter substrate-binding protein PnrA-like
SpyM6JRS4_RS04425	COG3845	ABC transporter
SpyM6JRS4_RS04430	COG4603	Belongs to the binding-protein-dependent transport system permease family
SpyM6JRS4_RS04435	COG1079	Belongs to the binding-protein-dependent transport system permease family
SpyM6JRS4_RS04440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SpyM6JRS4_RS04445	COG4684	Psort location CytoplasmicMembrane, score
SpyM6JRS4_RS04450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SpyM6JRS4_RS04460	COG0095	Lipoate-protein ligase
SpyM6JRS4_RS04470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SpyM6JRS4_RS04500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SpyM6JRS4_RS04505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SpyM6JRS4_RS04505	COG1328	CTP reductase activity
SpyM6JRS4_RS04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SpyM6JRS4_RS04515	COG0352	thiamine-phosphate diphosphorylase activity
SpyM6JRS4_RS04515	COG0351	phosphomethylpyrimidine kinase
SpyM6JRS4_RS04525	COG0488	(ABC) transporter
SpyM6JRS4_RS04545	COG2188	Transcriptional regulator
SpyM6JRS4_RS04555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SpyM6JRS4_RS04575	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SpyM6JRS4_RS04610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SpyM6JRS4_RS04615	COG0511	ligase activity, forming carbon-carbon bonds
SpyM6JRS4_RS04625	COG2851	Citrate transporter
SpyM6JRS4_RS04640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SpyM6JRS4_RS04645	COG0511	ligase activity, forming carbon-carbon bonds
SpyM6JRS4_RS04665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SpyM6JRS4_RS04670	COG0758	DNA mediated transformation
SpyM6JRS4_RS04690	COG1272	protein, Hemolysin III
SpyM6JRS4_RS04705	COG0346	lactoylglutathione lyase activity
SpyM6JRS4_RS04710	COG3764	Sortase (surface protein transpeptidase)
SpyM6JRS4_RS04730	COG1132	(ABC) transporter
SpyM6JRS4_RS04735	COG1132	(ABC) transporter
SpyM6JRS4_RS04765	COG2890	protein-(glutamine-N5) methyltransferase activity
SpyM6JRS4_RS04790	COG2233	PERMEase
SpyM6JRS4_RS04805	COG1174	glycine betaine transport
SpyM6JRS4_RS04820	COG4221	oxidoreductase activity
SpyM6JRS4_RS04825	COG0280	phosphate acetyltransferase
SpyM6JRS4_RS04830	COG0564	pseudouridine synthase activity
SpyM6JRS4_RS04840	COG2357	RelA SpoT domain protein
SpyM6JRS4_RS04855	COG1104	cysteine desulfurase activity
SpyM6JRS4_RS04870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SpyM6JRS4_RS04890	COG0038	chloride channel
SpyM6JRS4_RS04895	COG3700	Belongs to the class B bacterial acid phosphatase family
SpyM6JRS4_RS04910	COG3493	citrate carrier protein
SpyM6JRS4_RS04915	COG3290	protein histidine kinase activity
SpyM6JRS4_RS04920	COG4565	transcriptional regulatory protein
SpyM6JRS4_RS04930	COG1177	transmembrane transport
SpyM6JRS4_RS04935	COG1176	ABC-type spermidine putrescine transport system, permease component I
SpyM6JRS4_RS04970	COG0285	dihydrofolate synthase activity
SpyM6JRS4_RS05025	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SpyM6JRS4_RS05025	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SpyM6JRS4_RS05030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SpyM6JRS4_RS05035	COG1956	GAF domain-containing protein
SpyM6JRS4_RS05055	COG0513	Belongs to the DEAD box helicase family
SpyM6JRS4_RS05060	COG0726	polysaccharide deacetylase
SpyM6JRS4_RS05080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SpyM6JRS4_RS05085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SpyM6JRS4_RS05105	COG2801	Transposase and inactivated derivatives
SpyM6JRS4_RS05110	COG2801	Transposase and inactivated derivatives
SpyM6JRS4_RS05115	COG2801	Transposase and inactivated derivatives
SpyM6JRS4_RS05130	COG1476	TRANSCRIPTIONal
SpyM6JRS4_RS05145	COG4122	O-methyltransferase activity
SpyM6JRS4_RS05150	COG2223	nitrite transmembrane transporter activity
SpyM6JRS4_RS05165	COG1187	pseudouridine synthase activity
SpyM6JRS4_RS05205	COG0658	competence protein
SpyM6JRS4_RS05205	COG2333	competence protein COMEC
SpyM6JRS4_RS05240	COG1555	photosystem II stabilization
SpyM6JRS4_RS05245	COG0204	Acyl-transferase
SpyM6JRS4_RS05250	COG2890	protein-(glutamine-N5) methyltransferase activity
SpyM6JRS4_RS05265	COG0513	Belongs to the DEAD box helicase family
SpyM6JRS4_RS05280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SpyM6JRS4_RS05300	COG2116	formate transmembrane transporter activity
SpyM6JRS4_RS05310	COG1827	regulation of RNA biosynthetic process
SpyM6JRS4_RS05325	COG2217	Heavy metal translocating P-type atpase
SpyM6JRS4_RS05355	COG4824	toxin secretion phage lysis holin
SpyM6JRS4_RS05530	COG3723	Recombinational DNA repair protein, rece pathway
SpyM6JRS4_RS05575	COG1396	sequence-specific DNA binding
SpyM6JRS4_RS05585	COG0582	viral genome integration into host DNA
SpyM6JRS4_RS05600	COG2755	lipolytic protein G-D-S-L family
SpyM6JRS4_RS05615	COG0497	DNA recombination
SpyM6JRS4_RS05620	COG1438	arginine binding
SpyM6JRS4_RS05625	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SpyM6JRS4_RS05650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SpyM6JRS4_RS05655	COG0415	Belongs to the DNA photolyase family
SpyM6JRS4_RS05665	COG0765	amino acid transport
SpyM6JRS4_RS05670	COG4703	Protein of unknown function (DUF1797)
SpyM6JRS4_RS05675	COG0542	response to heat
SpyM6JRS4_RS05680	COG0494	nUDIX hydrolase
SpyM6JRS4_RS05695	COG3599	regulation of cell shape
SpyM6JRS4_RS05700	COG2302	S4 RNA-binding domain
SpyM6JRS4_RS05715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SpyM6JRS4_RS05750	COG1217	gtp-binding protein TYPA
SpyM6JRS4_RS05755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SpyM6JRS4_RS05760	COG1940	carbohydrate kinase activity
SpyM6JRS4_RS05770	COG0783	Belongs to the Dps family
SpyM6JRS4_RS05785	COG4470	Protein conserved in bacteria
SpyM6JRS4_RS05795	COG3480	Lon protease (S16) C-terminal proteolytic domain
SpyM6JRS4_RS05805	COG0742	ribosomal rna small subunit methyltransferase
SpyM6JRS4_RS05815	COG0549	Belongs to the carbamate kinase family
SpyM6JRS4_RS05820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SpyM6JRS4_RS05825	COG1288	antiporter activity
SpyM6JRS4_RS05835	COG0454	-acetyltransferase
SpyM6JRS4_RS05840	COG2235	arginine
SpyM6JRS4_RS05865	COG2972	Histidine kinase
SpyM6JRS4_RS05880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SpyM6JRS4_RS05885	COG0785	Cytochrome C biogenesis protein
SpyM6JRS4_RS05895	COG0673	inositol 2-dehydrogenase activity
SpyM6JRS4_RS05940	COG1605	Chorismate mutase
SpyM6JRS4_RS05940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SpyM6JRS4_RS05960	COG2226	methyltransferase
SpyM6JRS4_RS05970	COG3250	beta-galactosidase activity
SpyM6JRS4_RS05975	COG2207	Transcriptional regulator
SpyM6JRS4_RS05975	COG4753	response regulator
SpyM6JRS4_RS05980	COG2972	Histidine kinase
SpyM6JRS4_RS05990	COG1653	transport
SpyM6JRS4_RS05995	COG0395	ABC-type sugar transport system, permease component
SpyM6JRS4_RS06000	COG1175	transmembrane transport
SpyM6JRS4_RS06005	COG1940	carbohydrate kinase activity
SpyM6JRS4_RS06010	COG2723	6-phospho-beta-galactosidase activity
SpyM6JRS4_RS06015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SpyM6JRS4_RS06030	COG0383	alpha-mannosidase activity
SpyM6JRS4_RS06065	COG0860	N-Acetylmuramoyl-L-alanine amidase
SpyM6JRS4_RS06065	COG1388	LysM domain
SpyM6JRS4_RS06210	COG1475	DNA binding
SpyM6JRS4_RS06320	COG3561	AntA/AntB antirepressor
SpyM6JRS4_RS06425	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SpyM6JRS4_RS06430	COG1739	Uncharacterized protein family UPF0029
SpyM6JRS4_RS06440	COG1098	S1 RNA binding domain
SpyM6JRS4_RS06450	COG2197	response regulator
SpyM6JRS4_RS06455	COG4585	Histidine kinase
SpyM6JRS4_RS06465	COG2815	serine threonine protein kinase
SpyM6JRS4_RS06465	COG0515	serine threonine protein kinase
SpyM6JRS4_RS06475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SpyM6JRS4_RS06475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SpyM6JRS4_RS06485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SpyM6JRS4_RS06505	COG0583	DNA-binding transcription factor activity
SpyM6JRS4_RS06510	COG0183	Belongs to the thiolase family
SpyM6JRS4_RS06515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SpyM6JRS4_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
SpyM6JRS4_RS06530	COG2610	gluconate transmembrane transporter activity
SpyM6JRS4_RS06545	COG0116	Belongs to the methyltransferase superfamily
SpyM6JRS4_RS06565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SpyM6JRS4_RS06570	COG3579	cysteine-type endopeptidase activity
SpyM6JRS4_RS06580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SpyM6JRS4_RS06585	COG1113	amino acid transport
SpyM6JRS4_RS06590	COG0492	ferredoxin-NADP+ reductase activity
SpyM6JRS4_RS06600	COG1126	abc transporter atp-binding protein
SpyM6JRS4_RS06610	COG0513	Belongs to the DEAD box helicase family
SpyM6JRS4_RS06620	COG0768	penicillin binding
SpyM6JRS4_RS06660	COG1131	(ABC) transporter
SpyM6JRS4_RS06685	COG0446	pyridine nucleotide-disulphide oxidoreductase
SpyM6JRS4_RS06690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SpyM6JRS4_RS06725	COG1755	Isoprenylcysteine carboxyl methyltransferase
SpyM6JRS4_RS06730	COG0656	L-ascorbic acid biosynthetic process
SpyM6JRS4_RS06740	COG1283	sodium-dependent phosphate transmembrane transporter activity
SpyM6JRS4_RS06760	COG0561	phosphatase activity
SpyM6JRS4_RS06765	COG2860	membrane
SpyM6JRS4_RS06815	COG2217	Heavy metal translocating P-type atpase
SpyM6JRS4_RS06845	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SpyM6JRS4_RS06850	COG0195	Participates in both transcription termination and antitermination
SpyM6JRS4_RS06875	COG4473	ABC transporter
SpyM6JRS4_RS06880	COG1131	(ABC) transporter
SpyM6JRS4_RS06885	COG0537	adenosine 5'-monophosphoramidase activity
SpyM6JRS4_RS06895	COG1316	TRANSCRIPTIONal
SpyM6JRS4_RS06905	COG0802	atpase or kinase
SpyM6JRS4_RS06910	COG2252	PERMEase
SpyM6JRS4_RS06915	COG0561	phosphatase activity
SpyM6JRS4_RS06925	COG3715	PTS system
SpyM6JRS4_RS06930	COG3716	PTS system mannose fructose sorbose family IID component
SpyM6JRS4_RS06955	COG0439	Biotin carboxylase
SpyM6JRS4_RS06970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SpyM6JRS4_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
SpyM6JRS4_RS06980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SpyM6JRS4_RS07005	COG1024	Enoyl-CoA hydratase
SpyM6JRS4_RS07040	COG0588	phosphoglycerate mutase activity
SpyM6JRS4_RS07045	COG2261	transglycosylase associated protein
SpyM6JRS4_RS07070	COG0574	Belongs to the PEP-utilizing enzyme family
SpyM6JRS4_RS07070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SpyM6JRS4_RS07075	COG1335	isochorismatase
SpyM6JRS4_RS07085	COG0436	Aminotransferase
SpyM6JRS4_RS07095	COG0561	phosphatase activity
SpyM6JRS4_RS07100	COG0252	asparaginase activity
SpyM6JRS4_RS07115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SpyM6JRS4_RS07120	COG1129	ABC transporter
SpyM6JRS4_RS07135	COG1132	(ABC) transporter
SpyM6JRS4_RS07140	COG4988	ABC transporter
SpyM6JRS4_RS07145	COG1120	ATPase activity
SpyM6JRS4_RS07170	COG3942	CHAP domain
SpyM6JRS4_RS07170	COG1388	LysM domain
SpyM6JRS4_RS07195	COG1482	cell wall glycoprotein biosynthetic process
SpyM6JRS4_RS07200	COG1940	carbohydrate kinase activity
SpyM6JRS4_RS07210	COG1263	PTS System
SpyM6JRS4_RS07210	COG2190	(PTS) system
SpyM6JRS4_RS07210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SpyM6JRS4_RS07215	COG1621	beta-fructofuranosidase activity
SpyM6JRS4_RS07220	COG1609	Transcriptional regulator
SpyM6JRS4_RS07240	COG2131	deaminase
SpyM6JRS4_RS07245	COG0006	proline dipeptidase activity
SpyM6JRS4_RS07260	COG1388	LysM domain
SpyM6JRS4_RS07260	COG0860	N-Acetylmuramoyl-L-alanine amidase
SpyM6JRS4_RS07380	COG1783	phage Terminase large subunit
SpyM6JRS4_RS07515	COG1194	a g-specific adenine glycosylase
SpyM6JRS4_RS07525	COG3118	belongs to the thioredoxin family
SpyM6JRS4_RS07555	COG0681	Belongs to the peptidase S26 family
SpyM6JRS4_RS07560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SpyM6JRS4_RS07575	COG1882	Formate acetyltransferase
SpyM6JRS4_RS07580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SpyM6JRS4_RS07595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SpyM6JRS4_RS07600	COG2814	Major facilitator Superfamily
SpyM6JRS4_RS07605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SpyM6JRS4_RS07630	COG0789	Transcriptional regulator
SpyM6JRS4_RS07645	COG2081	HI0933 family
SpyM6JRS4_RS07655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SpyM6JRS4_RS07660	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SpyM6JRS4_RS07680	COG0456	acetyltransferase
SpyM6JRS4_RS07685	COG1214	PFAM Peptidase M22, glycoprotease
SpyM6JRS4_RS07700	COG0174	glutamine synthetase
SpyM6JRS4_RS07705	COG0789	Transcriptional regulator
SpyM6JRS4_RS07720	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SpyM6JRS4_RS07775	COG0668	transmembrane transport
SpyM6JRS4_RS07785	COG4720	Psort location CytoplasmicMembrane, score
SpyM6JRS4_RS07790	COG0351	phosphomethylpyrimidine kinase
SpyM6JRS4_RS07835	COG1929	Belongs to the glycerate kinase type-1 family
SpyM6JRS4_RS07840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SpyM6JRS4_RS07870	COG0577	efflux transmembrane transporter activity
SpyM6JRS4_RS07875	COG1136	(ABC) transporter
SpyM6JRS4_RS07900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SpyM6JRS4_RS07900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SpyM6JRS4_RS07905	COG1447	Phosphotransferase system cellobiose-specific component IIA
SpyM6JRS4_RS07955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SpyM6JRS4_RS07960	COG1476	TRANSCRIPTIONal
SpyM6JRS4_RS07980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SpyM6JRS4_RS07990	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SpyM6JRS4_RS08010	COG1045	serine acetyltransferase
SpyM6JRS4_RS08025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SpyM6JRS4_RS08040	COG3711	transcriptional antiterminator
SpyM6JRS4_RS08065	COG1846	Transcriptional regulator
SpyM6JRS4_RS08085	COG4589	Belongs to the CDS family
SpyM6JRS4_RS08095	COG1862	Preprotein translocase
SpyM6JRS4_RS08105	COG1523	belongs to the glycosyl hydrolase 13 family
SpyM6JRS4_RS08115	COG3842	ATPase activity
SpyM6JRS4_RS08155	COG1263	PTS System
SpyM6JRS4_RS08155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SpyM6JRS4_RS08155	COG2190	(PTS) system
SpyM6JRS4_RS08160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SpyM6JRS4_RS08180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SpyM6JRS4_RS08185	COG0512	Glutamine amidotransferase of anthranilate synthase
SpyM6JRS4_RS08190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SpyM6JRS4_RS08220	COG0601	transmembrane transport
SpyM6JRS4_RS08230	COG1122	ATPase activity
SpyM6JRS4_RS08250	COG0803	Belongs to the bacterial solute-binding protein 9 family
SpyM6JRS4_RS08265	COG3711	transcriptional antiterminator
SpyM6JRS4_RS08275	COG1705	Flagellar rod assembly protein muramidase FlgJ
SpyM6JRS4_RS08275	COG3942	CHAP domain
SpyM6JRS4_RS08280	COG2205	protein histidine kinase activity
SpyM6JRS4_RS08285	COG0745	RESPONSE REGULATOR receiver
SpyM6JRS4_RS08290	COG0577	efflux transmembrane transporter activity
SpyM6JRS4_RS08295	COG1136	(ABC) transporter
SpyM6JRS4_RS08345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SpyM6JRS4_RS08360	COG1882	Formate acetyltransferase
SpyM6JRS4_RS08365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SpyM6JRS4_RS08370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SpyM6JRS4_RS08375	COG1447	Phosphotransferase system cellobiose-specific component IIA
SpyM6JRS4_RS08380	COG2390	Transcriptional regulator
SpyM6JRS4_RS08385	COG1349	DNA-binding transcription factor activity
SpyM6JRS4_RS08390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SpyM6JRS4_RS08405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SpyM6JRS4_RS08420	COG0564	pseudouridine synthase activity
SpyM6JRS4_RS08450	COG0542	response to heat
SpyM6JRS4_RS08455	COG4463	regulation of RNA biosynthetic process
SpyM6JRS4_RS08470	COG0450	alkyl hydroperoxide reductase
SpyM6JRS4_RS08485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SpyM6JRS4_RS08495	COG3404	Formiminotransferase-cyclodeaminase
SpyM6JRS4_RS08510	COG0531	amino acid
SpyM6JRS4_RS08545	COG3590	peptidase
SpyM6JRS4_RS08550	COG0366	Alpha amylase catalytic
SpyM6JRS4_RS08555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SpyM6JRS4_RS08555	COG1263	PTS System
SpyM6JRS4_RS08560	COG2188	Transcriptional regulator
SpyM6JRS4_RS08565	COG1733	regulation of RNA biosynthetic process
SpyM6JRS4_RS08570	COG2514	catechol 2,3-dioxygenase activity
SpyM6JRS4_RS08580	COG0602	queuosine metabolic process
SpyM6JRS4_RS08595	COG1328	CTP reductase activity
SpyM6JRS4_RS08620	COG1393	Belongs to the ArsC family
SpyM6JRS4_RS08635	COG0519	Catalyzes the synthesis of GMP from XMP
SpyM6JRS4_RS08675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SpyM6JRS4_RS08680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SpyM6JRS4_RS08685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SpyM6JRS4_RS08775	COG1511	domain protein
SpyM6JRS4_RS08795	COG0305	Participates in initiation and elongation during chromosome replication
SpyM6JRS4_RS08820	COG1760	l-serine dehydratase
SpyM6JRS4_RS08825	COG1760	l-serine dehydratase
SpyM6JRS4_RS08830	COG0741	lytic transglycosylase activity
SpyM6JRS4_RS08835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SpyM6JRS4_RS08850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SpyM6JRS4_RS08860	COG0612	Peptidase, M16
SpyM6JRS4_RS08865	COG0612	Peptidase, M16
SpyM6JRS4_RS08880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SpyM6JRS4_RS08905	COG0516	GMP reductase activity
SpyM6JRS4_RS08905	COG0517	IMP dehydrogenase activity
SpyM6JRS4_RS08915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SpyM6JRS4_RS08920	COG0488	(ABC) transporter
SpyM6JRS4_RS08960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SpyM6JRS4_RS08965	COG1475	DNA binding