locus-tag	class	description
SPYJRS4_RS00010	COG0592	DNA-directed DNA polymerase activity
SPYJRS4_RS00020	COG0012	GTP binding
SPYJRS4_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYJRS4_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYJRS4_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYJRS4_RS00070	COG0531	amino acid
SPYJRS4_RS00245	COG3942	CHAP domain
SPYJRS4_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYJRS4_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYJRS4_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYJRS4_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYJRS4_RS00315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPYJRS4_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYJRS4_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYJRS4_RS00355	COG1454	alcohol dehydrogenase
SPYJRS4_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
SPYJRS4_RS00360	COG1064	alcohol dehydrogenase
SPYJRS4_RS00365	COG0534	Mate efflux family protein
SPYJRS4_RS00475	COG0201	protein transport
SPYJRS4_RS00615	COG1121	(ABC) transporter
SPYJRS4_RS00620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYJRS4_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYJRS4_RS00655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYJRS4_RS00660	COG1459	type II secretion system
SPYJRS4_RS00665	COG4537	Required for transformation and DNA binding
SPYJRS4_RS00705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYJRS4_RS00710	COG1363	Peptidase, m42
SPYJRS4_RS00720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYJRS4_RS00725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYJRS4_RS00740	COG1428	Deoxynucleoside kinase
SPYJRS4_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYJRS4_RS00785	COG2031	fatty acid transporter
SPYJRS4_RS00800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYJRS4_RS00815	COG0251	oxidation-reduction process
SPYJRS4_RS00830	COG1269	ATP hydrolysis coupled proton transport
SPYJRS4_RS00835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYJRS4_RS00845	COG1527	subunit (C
SPYJRS4_RS00850	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYJRS4_RS00885	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYJRS4_RS00920	COG0626	cystathionine gamma-synthase activity
SPYJRS4_RS00950	COG3623	hexulose-6-phosphate isomerase
SPYJRS4_RS00970	COG4175	Glycine betaine
SPYJRS4_RS00970	COG3448	diguanylate cyclase activity
SPYJRS4_RS00980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYJRS4_RS00980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYJRS4_RS01005	COG1268	BioY protein
SPYJRS4_RS01010	COG1234	tRNA 3'-trailer cleavage
SPYJRS4_RS01045	COG0457	Tetratricopeptide repeat
SPYJRS4_RS01045	COG0705	Rhomboid family
SPYJRS4_RS01065	COG1132	(ABC) transporter
SPYJRS4_RS01070	COG1132	(ABC) transporter
SPYJRS4_RS01080	COG0756	dUTP diphosphatase activity
SPYJRS4_RS01105	COG3290	protein histidine kinase activity
SPYJRS4_RS01130	COG1847	R3H domain protein
SPYJRS4_RS01150	COG1175	transmembrane transport
SPYJRS4_RS01155	COG0395	ABC-type sugar transport system, permease component
SPYJRS4_RS01165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYJRS4_RS01180	COG0084	hydrolase, TatD family'
SPYJRS4_RS01205	COG1564	THIamine pyrophosphokinase
SPYJRS4_RS01220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYJRS4_RS01255	COG0765	amino acid transport
SPYJRS4_RS01275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYJRS4_RS01285	COG0719	Fe-S assembly protein
SPYJRS4_RS01290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYJRS4_RS01305	COG1686	Belongs to the peptidase S11 family
SPYJRS4_RS01310	COG1686	Belongs to the peptidase S11 family
SPYJRS4_RS01315	COG4166	transmembrane transport
SPYJRS4_RS01320	COG0601	transmembrane transport
SPYJRS4_RS01325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYJRS4_RS01330	COG0444	Belongs to the ABC transporter superfamily
SPYJRS4_RS01380	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYJRS4_RS01385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYJRS4_RS01390	COG1534	Rna-binding protein
SPYJRS4_RS01400	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYJRS4_RS01405	COG0799	negative regulation of ribosome biogenesis
SPYJRS4_RS01410	COG2226	methyltransferase
SPYJRS4_RS01425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYJRS4_RS01430	COG1464	Belongs to the NlpA lipoprotein family
SPYJRS4_RS01445	COG1114	Component of the transport system for branched-chain amino acids
SPYJRS4_RS01455	COG0569	domain protein
SPYJRS4_RS01460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYJRS4_RS01470	COG1704	LemA family
SPYJRS4_RS01485	COG0745	RESPONSE REGULATOR receiver
SPYJRS4_RS01505	COG1484	DNA-dependent DNA replication
SPYJRS4_RS01515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYJRS4_RS01535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYJRS4_RS01550	COG1254	Belongs to the acylphosphatase family
SPYJRS4_RS01555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYJRS4_RS01610	COG1187	pseudouridine synthase activity
SPYJRS4_RS01625	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYJRS4_RS01630	COG0671	phosphoesterase, PA-phosphatase related
SPYJRS4_RS01635	COG1242	4 iron, 4 sulfur cluster binding
SPYJRS4_RS01640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYJRS4_RS01645	COG1253	flavin adenine dinucleotide binding
SPYJRS4_RS01650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYJRS4_RS01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYJRS4_RS01670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYJRS4_RS01675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYJRS4_RS01680	COG1120	ATPase activity
SPYJRS4_RS01690	COG2244	polysaccharide biosynthetic process
SPYJRS4_RS01715	COG0470	DNA polymerase III
SPYJRS4_RS01745	COG1393	Belongs to the ArsC family
SPYJRS4_RS01750	COG0708	Exodeoxyribonuclease III
SPYJRS4_RS01760	COG1304	FMN binding
SPYJRS4_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
SPYJRS4_RS01825	COG0673	inositol 2-dehydrogenase activity
SPYJRS4_RS01840	COG0494	nUDIX hydrolase
SPYJRS4_RS01850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYJRS4_RS01955	COG1702	phosphate starvation-inducible protein PhoH
SPYJRS4_RS01960	COG1573	uracil-dna glycosylase
SPYJRS4_RS01970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYJRS4_RS01995	COG3328	transposase activity
SPYJRS4_RS02000	COG3328	transposase activity
SPYJRS4_RS02075	COG2814	Major facilitator Superfamily
SPYJRS4_RS02085	COG0557	exoribonuclease II activity
SPYJRS4_RS02115	COG0463	Glycosyl transferase, family 2
SPYJRS4_RS02125	COG0778	Nitroreductase
SPYJRS4_RS02130	COG0006	proline dipeptidase activity
SPYJRS4_RS02135	COG1609	Transcriptional regulator
SPYJRS4_RS02145	COG0438	transferase activity, transferring glycosyl groups
SPYJRS4_RS02155	COG4555	ABC transporter
SPYJRS4_RS02170	COG2376	Dihydroxyacetone kinase
SPYJRS4_RS02180	COG2376	Dihydroxyacetone kinase
SPYJRS4_RS02185	COG1461	Dihydroxyacetone kinase
SPYJRS4_RS02190	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPYJRS4_RS02195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYJRS4_RS02205	COG0183	Belongs to the thiolase family
SPYJRS4_RS02220	COG0745	RESPONSE REGULATOR receiver
SPYJRS4_RS02225	COG5002	protein histidine kinase activity
SPYJRS4_RS02230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYJRS4_RS02240	COG1196	nuclear chromosome segregation
SPYJRS4_RS02250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYJRS4_RS02335	COG4695	Portal protein
SPYJRS4_RS02345	COG0561	phosphatase activity
SPYJRS4_RS02350	COG0561	phosphatase activity
SPYJRS4_RS02355	COG0552	protein localization to endoplasmic reticulum
SPYJRS4_RS02360	COG0477	Major facilitator Superfamily
SPYJRS4_RS02370	COG2190	(PTS) system
SPYJRS4_RS02370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYJRS4_RS02370	COG1263	PTS System
SPYJRS4_RS02380	COG3689	TIGRFAM TIGR03943 family protein
SPYJRS4_RS02385	COG0701	Predicted permease
SPYJRS4_RS02390	COG2183	response to ionizing radiation
SPYJRS4_RS02435	COG0826	peptidase U32
SPYJRS4_RS02440	COG4443	Transcriptional Coactivator p15 (PC4)
SPYJRS4_RS02485	COG0386	Belongs to the glutathione peroxidase family
SPYJRS4_RS02490	COG1164	Oligoendopeptidase f
SPYJRS4_RS02500	COG0772	Belongs to the SEDS family
SPYJRS4_RS02535	COG1078	dGTPase activity
SPYJRS4_RS02550	COG1609	Transcriptional regulator
SPYJRS4_RS02560	COG3716	PTS system mannose fructose sorbose family IID component
SPYJRS4_RS02565	COG3715	PTS system
SPYJRS4_RS02570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYJRS4_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
SPYJRS4_RS02600	COG0800	Aldolase
SPYJRS4_RS02605	COG0546	phosphoglycolate phosphatase activity
SPYJRS4_RS02610	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYJRS4_RS02620	COG2884	Cell division ATP-binding protein ftsE
SPYJRS4_RS02625	COG2177	Part of the ABC transporter FtsEX involved in
SPYJRS4_RS02640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYJRS4_RS02640	COG1199	ATP-dependent helicase activity
SPYJRS4_RS02645	COG0436	Aminotransferase
SPYJRS4_RS02680	COG2188	Transcriptional regulator
SPYJRS4_RS02685	COG2222	sugar isomerase
SPYJRS4_RS02695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYJRS4_RS02700	COG0716	FMN binding
SPYJRS4_RS02710	COG0038	chloride channel
SPYJRS4_RS02780	COG1131	(ABC) transporter
SPYJRS4_RS02800	COG4708	membrane
SPYJRS4_RS02810	COG1597	lipid kinase activity
SPYJRS4_RS02895	COG0577	efflux transmembrane transporter activity
SPYJRS4_RS02905	COG2321	neutral zinc metallopeptidase
SPYJRS4_RS02920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYJRS4_RS02930	COG1970	mechanosensitive ion channel activity
SPYJRS4_RS02935	COG0358	DNA primase activity
SPYJRS4_RS02940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYJRS4_RS02945	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYJRS4_RS02990	COG1216	Glycosyl transferase, family 2
SPYJRS4_RS03045	COG1368	sulfuric ester hydrolase activity
SPYJRS4_RS03050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYJRS4_RS03070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYJRS4_RS03075	COG0285	dihydrofolate synthase activity
SPYJRS4_RS03085	COG1104	cysteine desulfurase activity
SPYJRS4_RS03115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYJRS4_RS03120	COG0583	DNA-binding transcription factor activity
SPYJRS4_RS03130	COG0564	pseudouridine synthase activity
SPYJRS4_RS03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYJRS4_RS03165	COG1136	(ABC) transporter
SPYJRS4_RS03170	COG0577	efflux transmembrane transporter activity
SPYJRS4_RS03175	COG0584	glycerophosphoryl diester phosphodiesterase
SPYJRS4_RS03185	COG1837	Belongs to the UPF0109 family
SPYJRS4_RS03235	COG1349	DNA-binding transcription factor activity
SPYJRS4_RS03240	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYJRS4_RS03245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYJRS4_RS03245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYJRS4_RS03245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYJRS4_RS03250	COG1388	LysM domain
SPYJRS4_RS03250	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYJRS4_RS03255	COG1388	LysM domain
SPYJRS4_RS03255	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYJRS4_RS03275	COG0105	UTP biosynthetic process
SPYJRS4_RS03295	COG0488	(ABC) transporter
SPYJRS4_RS03305	COG0242	peptide deformylase activity
SPYJRS4_RS03310	COG0737	Belongs to the 5'-nucleotidase family
SPYJRS4_RS03315	COG2357	RelA SpoT domain protein
SPYJRS4_RS03320	COG0745	RESPONSE REGULATOR receiver
SPYJRS4_RS03355	COG3425	synthase
SPYJRS4_RS03365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYJRS4_RS03405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPYJRS4_RS03420	COG0583	DNA-binding transcription factor activity
SPYJRS4_RS03445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYJRS4_RS03450	COG0765	amino acid transport
SPYJRS4_RS03470	COG0187	DNA topoisomerase II activity
SPYJRS4_RS03480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYJRS4_RS03500	COG0539	negative regulation of cytoplasmic translation
SPYJRS4_RS03515	COG2801	Transposase and inactivated derivatives
SPYJRS4_RS03590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYJRS4_RS03595	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYJRS4_RS03605	COG0300	oxidoreductase activity
SPYJRS4_RS03610	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYJRS4_RS03610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYJRS4_RS03625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYJRS4_RS03630	COG2384	SAM-dependent methyltransferase
SPYJRS4_RS03640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYJRS4_RS03645	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYJRS4_RS03655	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYJRS4_RS03660	COG1051	belongs to the nudix hydrolase family
SPYJRS4_RS03665	COG0628	permease
SPYJRS4_RS03675	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYJRS4_RS03690	COG1129	ABC transporter
SPYJRS4_RS03710	COG0488	(ABC) transporter
SPYJRS4_RS03715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYJRS4_RS03720	COG0022	dehydrogenase e1 component
SPYJRS4_RS03720	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYJRS4_RS03725	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYJRS4_RS03740	COG5492	domain, Protein
SPYJRS4_RS03745	COG0095	Lipoate-protein ligase
SPYJRS4_RS03750	COG3442	glutamine amidotransferase
SPYJRS4_RS03755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYJRS4_RS03760	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYJRS4_RS03780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYJRS4_RS03790	COG0647	UMP catabolic process
SPYJRS4_RS03835	COG3715	PTS system
SPYJRS4_RS03840	COG3716	PTS system mannose fructose sorbose family IID component
SPYJRS4_RS03845	COG2972	Histidine kinase
SPYJRS4_RS03850	COG4753	response regulator
SPYJRS4_RS03850	COG2207	Transcriptional regulator
SPYJRS4_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
SPYJRS4_RS03875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYJRS4_RS03895	COG4109	DRTGG domain
SPYJRS4_RS03945	COG2814	Major facilitator Superfamily
SPYJRS4_RS03955	COG1187	pseudouridine synthase activity
SPYJRS4_RS03970	COG0157	Belongs to the NadC ModD family
SPYJRS4_RS03975	COG2801	Transposase and inactivated derivatives
SPYJRS4_RS03995	COG2723	6-phospho-beta-galactosidase activity
SPYJRS4_RS04005	COG3711	transcriptional antiterminator
SPYJRS4_RS04005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYJRS4_RS04015	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYJRS4_RS04025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYJRS4_RS04030	COG1126	abc transporter atp-binding protein
SPYJRS4_RS04035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYJRS4_RS04055	COG1696	Membrane protein involved in D-alanine export
SPYJRS4_RS04065	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYJRS4_RS04070	COG0657	acetylesterase activity
SPYJRS4_RS04085	COG3833	ABC-type maltose transport systems, permease component
SPYJRS4_RS04090	COG1175	transmembrane transport
SPYJRS4_RS04095	COG2182	Extracellular solute-binding protein
SPYJRS4_RS04100	COG1609	Transcriptional regulator
SPYJRS4_RS04105	COG1640	4-alpha-glucanotransferase
SPYJRS4_RS04110	COG0058	SHG alpha-glucan phosphorylase activity
SPYJRS4_RS04135	COG1131	(ABC) transporter
SPYJRS4_RS04140	COG1725	Transcriptional regulator
SPYJRS4_RS04155	COG0469	pyruvate kinase activity
SPYJRS4_RS04175	COG2213	PTS system mannitol-specific
SPYJRS4_RS04180	COG3711	transcriptional antiterminator
SPYJRS4_RS04185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYJRS4_RS04190	COG0246	Mannitol dehydrogenase
SPYJRS4_RS04205	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYJRS4_RS04210	COG0765	amino acid transport
SPYJRS4_RS04215	COG1126	abc transporter atp-binding protein
SPYJRS4_RS04220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYJRS4_RS04230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYJRS4_RS04235	COG1115	amino acid carrier protein
SPYJRS4_RS04285	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYJRS4_RS04285	COG1136	(ABC) transporter
SPYJRS4_RS04315	COG0196	riboflavin kinase activity
SPYJRS4_RS04330	COG0483	inositol monophosphate 1-phosphatase activity
SPYJRS4_RS04335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYJRS4_RS04335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYJRS4_RS04345	COG0573	inorganic phosphate transmembrane transporter activity
SPYJRS4_RS04350	COG0581	inorganic phosphate transmembrane transporter activity
SPYJRS4_RS04365	COG0704	Plays a role in the regulation of phosphate uptake
SPYJRS4_RS04375	COG0745	RESPONSE REGULATOR receiver
SPYJRS4_RS04380	COG5002	protein histidine kinase activity
SPYJRS4_RS04395	COG2813	Specifically methylates the guanine in position
SPYJRS4_RS04400	COG0295	cytidine deaminase activity
SPYJRS4_RS04405	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYJRS4_RS04410	COG3845	ABC transporter
SPYJRS4_RS04415	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYJRS4_RS04420	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYJRS4_RS04425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYJRS4_RS04430	COG4684	Psort location CytoplasmicMembrane, score
SPYJRS4_RS04435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYJRS4_RS04445	COG0095	Lipoate-protein ligase
SPYJRS4_RS04455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYJRS4_RS04485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYJRS4_RS04490	COG1328	CTP reductase activity
SPYJRS4_RS04490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYJRS4_RS04495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYJRS4_RS04500	COG0352	thiamine-phosphate diphosphorylase activity
SPYJRS4_RS04500	COG0351	phosphomethylpyrimidine kinase
SPYJRS4_RS04510	COG0488	(ABC) transporter
SPYJRS4_RS04530	COG2188	Transcriptional regulator
SPYJRS4_RS04540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYJRS4_RS04560	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYJRS4_RS04590	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYJRS4_RS04595	COG0511	ligase activity, forming carbon-carbon bonds
SPYJRS4_RS04605	COG2851	Citrate transporter
SPYJRS4_RS04620	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYJRS4_RS04625	COG0511	ligase activity, forming carbon-carbon bonds
SPYJRS4_RS04645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYJRS4_RS04650	COG0758	DNA mediated transformation
SPYJRS4_RS04670	COG1272	protein, Hemolysin III
SPYJRS4_RS04685	COG0346	lactoylglutathione lyase activity
SPYJRS4_RS04690	COG3764	Sortase (surface protein transpeptidase)
SPYJRS4_RS04710	COG1132	(ABC) transporter
SPYJRS4_RS04715	COG1132	(ABC) transporter
SPYJRS4_RS04745	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYJRS4_RS04770	COG2233	PERMEase
SPYJRS4_RS04785	COG1174	glycine betaine transport
SPYJRS4_RS04800	COG4221	oxidoreductase activity
SPYJRS4_RS04805	COG0280	phosphate acetyltransferase
SPYJRS4_RS04810	COG0564	pseudouridine synthase activity
SPYJRS4_RS04820	COG2357	RelA SpoT domain protein
SPYJRS4_RS04835	COG1104	cysteine desulfurase activity
SPYJRS4_RS04850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYJRS4_RS04870	COG0038	chloride channel
SPYJRS4_RS04875	COG3700	Belongs to the class B bacterial acid phosphatase family
SPYJRS4_RS04890	COG3493	citrate carrier protein
SPYJRS4_RS04895	COG3290	protein histidine kinase activity
SPYJRS4_RS04900	COG4565	transcriptional regulatory protein
SPYJRS4_RS04910	COG1177	transmembrane transport
SPYJRS4_RS04915	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYJRS4_RS04950	COG0285	dihydrofolate synthase activity
SPYJRS4_RS05005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYJRS4_RS05005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYJRS4_RS05010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYJRS4_RS05015	COG1956	GAF domain-containing protein
SPYJRS4_RS05035	COG0513	Belongs to the DEAD box helicase family
SPYJRS4_RS05040	COG0726	polysaccharide deacetylase
SPYJRS4_RS05060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYJRS4_RS05065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYJRS4_RS05085	COG2801	Transposase and inactivated derivatives
SPYJRS4_RS05090	COG2801	Transposase and inactivated derivatives
SPYJRS4_RS05095	COG2801	Transposase and inactivated derivatives
SPYJRS4_RS05110	COG1476	TRANSCRIPTIONal
SPYJRS4_RS05125	COG4122	O-methyltransferase activity
SPYJRS4_RS05130	COG2223	nitrite transmembrane transporter activity
SPYJRS4_RS05145	COG1187	pseudouridine synthase activity
SPYJRS4_RS05185	COG0658	competence protein
SPYJRS4_RS05185	COG2333	competence protein COMEC
SPYJRS4_RS05220	COG1555	photosystem II stabilization
SPYJRS4_RS05225	COG0204	Acyl-transferase
SPYJRS4_RS05230	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYJRS4_RS05245	COG0513	Belongs to the DEAD box helicase family
SPYJRS4_RS05260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYJRS4_RS05275	COG2116	formate transmembrane transporter activity
SPYJRS4_RS05285	COG1827	regulation of RNA biosynthetic process
SPYJRS4_RS05300	COG2217	Heavy metal translocating P-type atpase
SPYJRS4_RS05325	COG4824	toxin secretion phage lysis holin
SPYJRS4_RS05500	COG3723	Recombinational DNA repair protein, rece pathway
SPYJRS4_RS05545	COG1396	sequence-specific DNA binding
SPYJRS4_RS05555	COG0582	viral genome integration into host DNA
SPYJRS4_RS05570	COG2755	lipolytic protein G-D-S-L family
SPYJRS4_RS05585	COG0497	DNA recombination
SPYJRS4_RS05590	COG1438	arginine binding
SPYJRS4_RS05595	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYJRS4_RS05620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYJRS4_RS05625	COG0415	Belongs to the DNA photolyase family
SPYJRS4_RS05635	COG0765	amino acid transport
SPYJRS4_RS05640	COG4703	Protein of unknown function (DUF1797)
SPYJRS4_RS05645	COG0542	response to heat
SPYJRS4_RS05650	COG0494	nUDIX hydrolase
SPYJRS4_RS05665	COG3599	regulation of cell shape
SPYJRS4_RS05670	COG2302	S4 RNA-binding domain
SPYJRS4_RS05685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYJRS4_RS05720	COG1217	gtp-binding protein TYPA
SPYJRS4_RS05725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYJRS4_RS05730	COG1940	carbohydrate kinase activity
SPYJRS4_RS05740	COG0783	Belongs to the Dps family
SPYJRS4_RS05755	COG4470	Protein conserved in bacteria
SPYJRS4_RS05765	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYJRS4_RS05775	COG0742	ribosomal rna small subunit methyltransferase
SPYJRS4_RS05785	COG0549	Belongs to the carbamate kinase family
SPYJRS4_RS05790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYJRS4_RS05795	COG1288	antiporter activity
SPYJRS4_RS05805	COG0454	-acetyltransferase
SPYJRS4_RS05810	COG2235	arginine
SPYJRS4_RS05835	COG2972	Histidine kinase
SPYJRS4_RS05850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYJRS4_RS05855	COG0785	Cytochrome C biogenesis protein
SPYJRS4_RS05865	COG0673	inositol 2-dehydrogenase activity
SPYJRS4_RS05905	COG1605	Chorismate mutase
SPYJRS4_RS05905	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYJRS4_RS05925	COG2226	methyltransferase
SPYJRS4_RS05935	COG3250	beta-galactosidase activity
SPYJRS4_RS05940	COG4753	response regulator
SPYJRS4_RS05940	COG2207	Transcriptional regulator
SPYJRS4_RS05945	COG2972	Histidine kinase
SPYJRS4_RS05955	COG1653	transport
SPYJRS4_RS05960	COG0395	ABC-type sugar transport system, permease component
SPYJRS4_RS05965	COG1175	transmembrane transport
SPYJRS4_RS05970	COG1940	carbohydrate kinase activity
SPYJRS4_RS05975	COG2723	6-phospho-beta-galactosidase activity
SPYJRS4_RS05980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYJRS4_RS05995	COG0383	alpha-mannosidase activity
SPYJRS4_RS06030	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYJRS4_RS06030	COG1388	LysM domain
SPYJRS4_RS06170	COG1475	DNA binding
SPYJRS4_RS06280	COG3561	AntA/AntB antirepressor
SPYJRS4_RS06385	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPYJRS4_RS06390	COG1739	Uncharacterized protein family UPF0029
SPYJRS4_RS06400	COG1098	S1 RNA binding domain
SPYJRS4_RS06410	COG2197	response regulator
SPYJRS4_RS06415	COG4585	Histidine kinase
SPYJRS4_RS06425	COG0515	serine threonine protein kinase
SPYJRS4_RS06425	COG2815	serine threonine protein kinase
SPYJRS4_RS06435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYJRS4_RS06435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYJRS4_RS06445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYJRS4_RS06465	COG0583	DNA-binding transcription factor activity
SPYJRS4_RS06470	COG0183	Belongs to the thiolase family
SPYJRS4_RS06475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYJRS4_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
SPYJRS4_RS06490	COG2610	gluconate transmembrane transporter activity
SPYJRS4_RS06505	COG0116	Belongs to the methyltransferase superfamily
SPYJRS4_RS06530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYJRS4_RS06535	COG3579	cysteine-type endopeptidase activity
SPYJRS4_RS06545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYJRS4_RS06550	COG1113	amino acid transport
SPYJRS4_RS06555	COG0492	ferredoxin-NADP+ reductase activity
SPYJRS4_RS06565	COG1126	abc transporter atp-binding protein
SPYJRS4_RS06575	COG0513	Belongs to the DEAD box helicase family
SPYJRS4_RS06585	COG0768	penicillin binding
SPYJRS4_RS06620	COG1131	(ABC) transporter
SPYJRS4_RS06645	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYJRS4_RS06650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYJRS4_RS06685	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYJRS4_RS06690	COG0656	L-ascorbic acid biosynthetic process
SPYJRS4_RS06700	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYJRS4_RS06720	COG0561	phosphatase activity
SPYJRS4_RS06725	COG2860	membrane
SPYJRS4_RS06775	COG2217	Heavy metal translocating P-type atpase
SPYJRS4_RS06805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYJRS4_RS06810	COG0195	Participates in both transcription termination and antitermination
SPYJRS4_RS06835	COG4473	ABC transporter
SPYJRS4_RS06840	COG1131	(ABC) transporter
SPYJRS4_RS06845	COG0537	adenosine 5'-monophosphoramidase activity
SPYJRS4_RS06855	COG1316	TRANSCRIPTIONal
SPYJRS4_RS06865	COG0802	atpase or kinase
SPYJRS4_RS06870	COG2252	PERMEase
SPYJRS4_RS06875	COG0561	phosphatase activity
SPYJRS4_RS06885	COG3715	PTS system
SPYJRS4_RS06890	COG3716	PTS system mannose fructose sorbose family IID component
SPYJRS4_RS06915	COG0439	Biotin carboxylase
SPYJRS4_RS06930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYJRS4_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
SPYJRS4_RS06940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYJRS4_RS06965	COG1024	Enoyl-CoA hydratase
SPYJRS4_RS07000	COG0588	phosphoglycerate mutase activity
SPYJRS4_RS07005	COG2261	transglycosylase associated protein
SPYJRS4_RS07030	COG0574	Belongs to the PEP-utilizing enzyme family
SPYJRS4_RS07030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYJRS4_RS07035	COG1335	isochorismatase
SPYJRS4_RS07045	COG0436	Aminotransferase
SPYJRS4_RS07055	COG0561	phosphatase activity
SPYJRS4_RS07060	COG0252	asparaginase activity
SPYJRS4_RS07075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYJRS4_RS07080	COG1129	ABC transporter
SPYJRS4_RS07095	COG1132	(ABC) transporter
SPYJRS4_RS07100	COG4988	ABC transporter
SPYJRS4_RS07105	COG1120	ATPase activity
SPYJRS4_RS07155	COG1482	cell wall glycoprotein biosynthetic process
SPYJRS4_RS07160	COG1940	carbohydrate kinase activity
SPYJRS4_RS07170	COG1263	PTS System
SPYJRS4_RS07170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYJRS4_RS07170	COG2190	(PTS) system
SPYJRS4_RS07175	COG1621	beta-fructofuranosidase activity
SPYJRS4_RS07180	COG1609	Transcriptional regulator
SPYJRS4_RS07200	COG2131	deaminase
SPYJRS4_RS07205	COG0006	proline dipeptidase activity
SPYJRS4_RS07220	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYJRS4_RS07220	COG1388	LysM domain
SPYJRS4_RS07335	COG1783	phage Terminase large subunit
SPYJRS4_RS07470	COG1194	a g-specific adenine glycosylase
SPYJRS4_RS07480	COG3118	belongs to the thioredoxin family
SPYJRS4_RS07510	COG0681	Belongs to the peptidase S26 family
SPYJRS4_RS07515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYJRS4_RS07530	COG1882	Formate acetyltransferase
SPYJRS4_RS07535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYJRS4_RS07550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYJRS4_RS07555	COG2814	Major facilitator Superfamily
SPYJRS4_RS07560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYJRS4_RS07585	COG0789	Transcriptional regulator
SPYJRS4_RS07600	COG2081	HI0933 family
SPYJRS4_RS07610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYJRS4_RS07615	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYJRS4_RS07635	COG0456	acetyltransferase
SPYJRS4_RS07640	COG1214	PFAM Peptidase M22, glycoprotease
SPYJRS4_RS07655	COG0174	glutamine synthetase
SPYJRS4_RS07660	COG0789	Transcriptional regulator
SPYJRS4_RS07675	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYJRS4_RS07730	COG0668	transmembrane transport
SPYJRS4_RS07740	COG4720	Psort location CytoplasmicMembrane, score
SPYJRS4_RS07745	COG0351	phosphomethylpyrimidine kinase
SPYJRS4_RS07790	COG1929	Belongs to the glycerate kinase type-1 family
SPYJRS4_RS07795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYJRS4_RS07825	COG0577	efflux transmembrane transporter activity
SPYJRS4_RS07830	COG1136	(ABC) transporter
SPYJRS4_RS07855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYJRS4_RS07855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYJRS4_RS07860	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYJRS4_RS07910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYJRS4_RS07915	COG1476	TRANSCRIPTIONal
SPYJRS4_RS07935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYJRS4_RS07945	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYJRS4_RS07965	COG1045	serine acetyltransferase
SPYJRS4_RS07980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYJRS4_RS07995	COG3711	transcriptional antiterminator
SPYJRS4_RS08020	COG1846	Transcriptional regulator
SPYJRS4_RS08040	COG4589	Belongs to the CDS family
SPYJRS4_RS08050	COG1862	Preprotein translocase
SPYJRS4_RS08060	COG1523	belongs to the glycosyl hydrolase 13 family
SPYJRS4_RS08070	COG3842	ATPase activity
SPYJRS4_RS08110	COG1263	PTS System
SPYJRS4_RS08110	COG2190	(PTS) system
SPYJRS4_RS08110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYJRS4_RS08115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYJRS4_RS08135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYJRS4_RS08140	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYJRS4_RS08145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYJRS4_RS08180	COG0601	transmembrane transport
SPYJRS4_RS08190	COG1122	ATPase activity
SPYJRS4_RS08210	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYJRS4_RS08225	COG3711	transcriptional antiterminator
SPYJRS4_RS08235	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYJRS4_RS08235	COG3942	CHAP domain
SPYJRS4_RS08240	COG2205	protein histidine kinase activity
SPYJRS4_RS08245	COG0745	RESPONSE REGULATOR receiver
SPYJRS4_RS08250	COG0577	efflux transmembrane transporter activity
SPYJRS4_RS08255	COG1136	(ABC) transporter
SPYJRS4_RS08305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYJRS4_RS08320	COG1882	Formate acetyltransferase
SPYJRS4_RS08325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYJRS4_RS08330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYJRS4_RS08335	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYJRS4_RS08340	COG2390	Transcriptional regulator
SPYJRS4_RS08345	COG1349	DNA-binding transcription factor activity
SPYJRS4_RS08350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYJRS4_RS08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYJRS4_RS08380	COG0564	pseudouridine synthase activity
SPYJRS4_RS08410	COG0542	response to heat
SPYJRS4_RS08415	COG4463	regulation of RNA biosynthetic process
SPYJRS4_RS08430	COG0450	alkyl hydroperoxide reductase
SPYJRS4_RS08445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYJRS4_RS08455	COG3404	Formiminotransferase-cyclodeaminase
SPYJRS4_RS08470	COG0531	amino acid
SPYJRS4_RS08505	COG3590	peptidase
SPYJRS4_RS08510	COG0366	Alpha amylase catalytic
SPYJRS4_RS08515	COG1263	PTS System
SPYJRS4_RS08515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYJRS4_RS08520	COG2188	Transcriptional regulator
SPYJRS4_RS08525	COG1733	regulation of RNA biosynthetic process
SPYJRS4_RS08530	COG2514	catechol 2,3-dioxygenase activity
SPYJRS4_RS08540	COG0602	queuosine metabolic process
SPYJRS4_RS08555	COG1328	CTP reductase activity
SPYJRS4_RS08580	COG1393	Belongs to the ArsC family
SPYJRS4_RS08595	COG0519	Catalyzes the synthesis of GMP from XMP
SPYJRS4_RS08635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYJRS4_RS08640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYJRS4_RS08645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYJRS4_RS08735	COG1511	domain protein
SPYJRS4_RS08755	COG0305	Participates in initiation and elongation during chromosome replication
SPYJRS4_RS08780	COG1760	l-serine dehydratase
SPYJRS4_RS08785	COG1760	l-serine dehydratase
SPYJRS4_RS08790	COG0741	lytic transglycosylase activity
SPYJRS4_RS08795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYJRS4_RS08810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYJRS4_RS08820	COG0612	Peptidase, M16
SPYJRS4_RS08825	COG0612	Peptidase, M16
SPYJRS4_RS08840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPYJRS4_RS08865	COG0517	IMP dehydrogenase activity
SPYJRS4_RS08865	COG0516	GMP reductase activity
SPYJRS4_RS08875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYJRS4_RS08880	COG0488	(ABC) transporter
SPYJRS4_RS08920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYJRS4_RS08925	COG1475	DNA binding