locus-tag	class	description
SPYKS030_RS00010	COG0592	DNA-directed DNA polymerase activity
SPYKS030_RS00020	COG0012	GTP binding
SPYKS030_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYKS030_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYKS030_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYKS030_RS00065	COG0531	amino acid
SPYKS030_RS00245	COG3942	CHAP domain
SPYKS030_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYKS030_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYKS030_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYKS030_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYKS030_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYKS030_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYKS030_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
SPYKS030_RS00355	COG1454	alcohol dehydrogenase
SPYKS030_RS00360	COG1064	alcohol dehydrogenase
SPYKS030_RS00365	COG0534	Mate efflux family protein
SPYKS030_RS00475	COG0201	protein transport
SPYKS030_RS00620	COG1121	(ABC) transporter
SPYKS030_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYKS030_RS00640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYKS030_RS00660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYKS030_RS00665	COG1459	type II secretion system
SPYKS030_RS00670	COG4537	Required for transformation and DNA binding
SPYKS030_RS00710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYKS030_RS00715	COG1363	Peptidase, m42
SPYKS030_RS00730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYKS030_RS00735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYKS030_RS00750	COG1428	Deoxynucleoside kinase
SPYKS030_RS00755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYKS030_RS00785	COG4509	Sortase family
SPYKS030_RS00810	COG2031	fatty acid transporter
SPYKS030_RS00825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYKS030_RS00840	COG0251	oxidation-reduction process
SPYKS030_RS00855	COG1269	ATP hydrolysis coupled proton transport
SPYKS030_RS00860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYKS030_RS00870	COG1527	subunit (C
SPYKS030_RS00875	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYKS030_RS00910	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYKS030_RS00950	COG0626	cystathionine gamma-synthase activity
SPYKS030_RS00980	COG3623	hexulose-6-phosphate isomerase
SPYKS030_RS01005	COG4175	Glycine betaine
SPYKS030_RS01005	COG3448	diguanylate cyclase activity
SPYKS030_RS01015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYKS030_RS01015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYKS030_RS01050	COG1268	BioY protein
SPYKS030_RS01055	COG1234	tRNA 3'-trailer cleavage
SPYKS030_RS01090	COG0457	Tetratricopeptide repeat
SPYKS030_RS01090	COG0705	Rhomboid family
SPYKS030_RS01110	COG1132	(ABC) transporter
SPYKS030_RS01115	COG1132	(ABC) transporter
SPYKS030_RS01125	COG0756	dUTP diphosphatase activity
SPYKS030_RS01150	COG3290	protein histidine kinase activity
SPYKS030_RS01175	COG1847	R3H domain protein
SPYKS030_RS01200	COG1175	transmembrane transport
SPYKS030_RS01205	COG0395	ABC-type sugar transport system, permease component
SPYKS030_RS01215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYKS030_RS01230	COG0084	hydrolase, TatD family'
SPYKS030_RS01255	COG1564	THIamine pyrophosphokinase
SPYKS030_RS01270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYKS030_RS01310	COG0765	amino acid transport
SPYKS030_RS01330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYKS030_RS01340	COG0719	Fe-S assembly protein
SPYKS030_RS01345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYKS030_RS01360	COG1686	Belongs to the peptidase S11 family
SPYKS030_RS01365	COG1686	Belongs to the peptidase S11 family
SPYKS030_RS01370	COG4166	transmembrane transport
SPYKS030_RS01375	COG0601	transmembrane transport
SPYKS030_RS01380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYKS030_RS01385	COG0444	Belongs to the ABC transporter superfamily
SPYKS030_RS01445	COG0351	phosphomethylpyrimidine kinase
SPYKS030_RS01450	COG4720	Psort location CytoplasmicMembrane, score
SPYKS030_RS01460	COG0668	transmembrane transport
SPYKS030_RS01515	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYKS030_RS01530	COG0789	Transcriptional regulator
SPYKS030_RS01535	COG0174	glutamine synthetase
SPYKS030_RS01550	COG1214	PFAM Peptidase M22, glycoprotease
SPYKS030_RS01555	COG0456	acetyltransferase
SPYKS030_RS01575	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYKS030_RS01580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYKS030_RS01590	COG2081	HI0933 family
SPYKS030_RS01605	COG0789	Transcriptional regulator
SPYKS030_RS01630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYKS030_RS01635	COG2814	Major facilitator Superfamily
SPYKS030_RS01645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYKS030_RS01660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYKS030_RS01670	COG1882	Formate acetyltransferase
SPYKS030_RS01685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYKS030_RS01690	COG0681	Belongs to the peptidase S26 family
SPYKS030_RS01720	COG3118	belongs to the thioredoxin family
SPYKS030_RS01725	COG3620	sequence-specific DNA binding
SPYKS030_RS01730	COG1194	a g-specific adenine glycosylase
SPYKS030_RS01770	COG0006	proline dipeptidase activity
SPYKS030_RS01775	COG2131	deaminase
SPYKS030_RS01795	COG1609	Transcriptional regulator
SPYKS030_RS01800	COG1621	beta-fructofuranosidase activity
SPYKS030_RS01805	COG1263	PTS System
SPYKS030_RS01805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYKS030_RS01805	COG2190	(PTS) system
SPYKS030_RS01815	COG1940	carbohydrate kinase activity
SPYKS030_RS01820	COG1482	cell wall glycoprotein biosynthetic process
SPYKS030_RS01840	COG3942	CHAP domain
SPYKS030_RS01840	COG1388	LysM domain
SPYKS030_RS01860	COG1120	ATPase activity
SPYKS030_RS01865	COG4988	ABC transporter
SPYKS030_RS01870	COG1132	(ABC) transporter
SPYKS030_RS01885	COG1129	ABC transporter
SPYKS030_RS01895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYKS030_RS01910	COG0252	asparaginase activity
SPYKS030_RS01915	COG0561	phosphatase activity
SPYKS030_RS01925	COG0436	Aminotransferase
SPYKS030_RS01935	COG1335	isochorismatase
SPYKS030_RS01945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYKS030_RS01945	COG0574	Belongs to the PEP-utilizing enzyme family
SPYKS030_RS01970	COG2261	transglycosylase associated protein
SPYKS030_RS01975	COG0588	phosphoglycerate mutase activity
SPYKS030_RS02010	COG1024	Enoyl-CoA hydratase
SPYKS030_RS02035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYKS030_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
SPYKS030_RS02045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYKS030_RS02060	COG0439	Biotin carboxylase
SPYKS030_RS02085	COG5433	transposase activity
SPYKS030_RS02095	COG3716	PTS system mannose fructose sorbose family IID component
SPYKS030_RS02100	COG3715	PTS system
SPYKS030_RS02110	COG0561	phosphatase activity
SPYKS030_RS02115	COG2252	PERMEase
SPYKS030_RS02120	COG0802	atpase or kinase
SPYKS030_RS02130	COG1316	TRANSCRIPTIONal
SPYKS030_RS02140	COG0537	adenosine 5'-monophosphoramidase activity
SPYKS030_RS02145	COG1131	(ABC) transporter
SPYKS030_RS02150	COG4473	ABC transporter
SPYKS030_RS02175	COG0195	Participates in both transcription termination and antitermination
SPYKS030_RS02180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYKS030_RS02210	COG2217	Heavy metal translocating P-type atpase
SPYKS030_RS02270	COG2860	membrane
SPYKS030_RS02275	COG0561	phosphatase activity
SPYKS030_RS02295	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYKS030_RS02305	COG0656	L-ascorbic acid biosynthetic process
SPYKS030_RS02310	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYKS030_RS02355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYKS030_RS02360	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYKS030_RS02385	COG1131	(ABC) transporter
SPYKS030_RS02500	COG1783	phage Terminase large subunit
SPYKS030_RS02615	COG1388	LysM domain
SPYKS030_RS02615	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYKS030_RS02660	COG0768	penicillin binding
SPYKS030_RS02670	COG0513	Belongs to the DEAD box helicase family
SPYKS030_RS02680	COG1126	abc transporter atp-binding protein
SPYKS030_RS02690	COG0492	ferredoxin-NADP+ reductase activity
SPYKS030_RS02695	COG1113	amino acid transport
SPYKS030_RS02700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYKS030_RS02710	COG3579	cysteine-type endopeptidase activity
SPYKS030_RS02715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYKS030_RS02740	COG0116	Belongs to the methyltransferase superfamily
SPYKS030_RS02755	COG2610	gluconate transmembrane transporter activity
SPYKS030_RS02775	COG0183	Belongs to the thiolase family
SPYKS030_RS02780	COG0583	DNA-binding transcription factor activity
SPYKS030_RS02800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYKS030_RS02810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYKS030_RS02810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYKS030_RS02820	COG2815	serine threonine protein kinase
SPYKS030_RS02820	COG0515	serine threonine protein kinase
SPYKS030_RS02830	COG4585	Histidine kinase
SPYKS030_RS02835	COG2197	response regulator
SPYKS030_RS02845	COG1098	S1 RNA binding domain
SPYKS030_RS02855	COG1739	Uncharacterized protein family UPF0029
SPYKS030_RS03230	COG0383	alpha-mannosidase activity
SPYKS030_RS03240	COG1609	Transcriptional regulator
SPYKS030_RS03245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYKS030_RS03250	COG2723	6-phospho-beta-galactosidase activity
SPYKS030_RS03255	COG1940	carbohydrate kinase activity
SPYKS030_RS03260	COG1175	transmembrane transport
SPYKS030_RS03265	COG0395	ABC-type sugar transport system, permease component
SPYKS030_RS03270	COG1653	transport
SPYKS030_RS03280	COG2972	Histidine kinase
SPYKS030_RS03285	COG4753	response regulator
SPYKS030_RS03285	COG2207	Transcriptional regulator
SPYKS030_RS03290	COG3250	beta-galactosidase activity
SPYKS030_RS03300	COG2226	methyltransferase
SPYKS030_RS03320	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYKS030_RS03320	COG1605	Chorismate mutase
SPYKS030_RS03370	COG0673	inositol 2-dehydrogenase activity
SPYKS030_RS03380	COG0785	Cytochrome C biogenesis protein
SPYKS030_RS03385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYKS030_RS03410	COG1396	sequence-specific DNA binding
SPYKS030_RS03420	COG3561	AntA/AntB antirepressor
SPYKS030_RS03455	COG3935	DnaD domain protein
SPYKS030_RS03555	COG1475	DNA binding
SPYKS030_RS03695	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYKS030_RS03695	COG1388	LysM domain
SPYKS030_RS03735	COG2972	Histidine kinase
SPYKS030_RS03775	COG1288	antiporter activity
SPYKS030_RS03780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYKS030_RS03785	COG0549	Belongs to the carbamate kinase family
SPYKS030_RS03795	COG0742	ribosomal rna small subunit methyltransferase
SPYKS030_RS03805	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYKS030_RS03810	COG1609	Transcriptional regulator
SPYKS030_RS03815	COG4470	Protein conserved in bacteria
SPYKS030_RS03830	COG0783	Belongs to the Dps family
SPYKS030_RS03840	COG1940	carbohydrate kinase activity
SPYKS030_RS03845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYKS030_RS03850	COG1217	gtp-binding protein TYPA
SPYKS030_RS03860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPYKS030_RS03885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYKS030_RS03900	COG2302	S4 RNA-binding domain
SPYKS030_RS03905	COG3599	regulation of cell shape
SPYKS030_RS03920	COG0494	nUDIX hydrolase
SPYKS030_RS03925	COG0542	response to heat
SPYKS030_RS03930	COG4703	Protein of unknown function (DUF1797)
SPYKS030_RS03935	COG0765	amino acid transport
SPYKS030_RS03945	COG0415	Belongs to the DNA photolyase family
SPYKS030_RS03950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYKS030_RS03975	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYKS030_RS03980	COG1438	arginine binding
SPYKS030_RS03985	COG0497	DNA recombination
SPYKS030_RS04000	COG2755	lipolytic protein G-D-S-L family
SPYKS030_RS04015	COG0582	viral genome integration into host DNA
SPYKS030_RS04025	COG1396	sequence-specific DNA binding
SPYKS030_RS04075	COG3723	Recombinational DNA repair protein, rece pathway
SPYKS030_RS04250	COG4824	toxin secretion phage lysis holin
SPYKS030_RS04270	COG2217	Heavy metal translocating P-type atpase
SPYKS030_RS04285	COG1827	regulation of RNA biosynthetic process
SPYKS030_RS04295	COG2116	formate transmembrane transporter activity
SPYKS030_RS04300	COG0768	penicillin binding
SPYKS030_RS04315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYKS030_RS04335	COG0513	Belongs to the DEAD box helicase family
SPYKS030_RS04350	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYKS030_RS04355	COG0204	Acyl-transferase
SPYKS030_RS04360	COG1596	polysaccharide export
SPYKS030_RS04360	COG1555	photosystem II stabilization
SPYKS030_RS04365	COG2333	competence protein COMEC
SPYKS030_RS04365	COG0658	competence protein
SPYKS030_RS04410	COG1187	pseudouridine synthase activity
SPYKS030_RS04425	COG2223	nitrite transmembrane transporter activity
SPYKS030_RS04430	COG4122	O-methyltransferase activity
SPYKS030_RS04445	COG1476	TRANSCRIPTIONal
SPYKS030_RS04475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYKS030_RS04480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYKS030_RS04485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYKS030_RS04505	COG0726	polysaccharide deacetylase
SPYKS030_RS04510	COG0513	Belongs to the DEAD box helicase family
SPYKS030_RS04530	COG1956	GAF domain-containing protein
SPYKS030_RS04535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYKS030_RS04545	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYKS030_RS04545	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYKS030_RS04570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPYKS030_RS04575	COG4109	DRTGG domain
SPYKS030_RS04625	COG2814	Major facilitator Superfamily
SPYKS030_RS04635	COG1187	pseudouridine synthase activity
SPYKS030_RS04640	COG2801	Transposase and inactivated derivatives
SPYKS030_RS04645	COG2801	Transposase and inactivated derivatives
SPYKS030_RS04660	COG0157	Belongs to the NadC ModD family
SPYKS030_RS04690	COG2723	6-phospho-beta-galactosidase activity
SPYKS030_RS04700	COG3711	transcriptional antiterminator
SPYKS030_RS04700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYKS030_RS04710	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYKS030_RS04720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYKS030_RS04725	COG1126	abc transporter atp-binding protein
SPYKS030_RS04730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYKS030_RS04750	COG1696	Membrane protein involved in D-alanine export
SPYKS030_RS04760	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYKS030_RS04765	COG0657	acetylesterase activity
SPYKS030_RS04785	COG3833	ABC-type maltose transport systems, permease component
SPYKS030_RS04790	COG1175	transmembrane transport
SPYKS030_RS04795	COG2182	Extracellular solute-binding protein
SPYKS030_RS04800	COG1609	Transcriptional regulator
SPYKS030_RS04805	COG1640	4-alpha-glucanotransferase
SPYKS030_RS04810	COG0058	SHG alpha-glucan phosphorylase activity
SPYKS030_RS04995	COG0740	serine-type endopeptidase activity
SPYKS030_RS05080	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYKS030_RS05115	COG0105	UTP biosynthetic process
SPYKS030_RS05150	COG3715	PTS system
SPYKS030_RS05155	COG3716	PTS system mannose fructose sorbose family IID component
SPYKS030_RS05160	COG2972	Histidine kinase
SPYKS030_RS05165	COG2207	Transcriptional regulator
SPYKS030_RS05165	COG4753	response regulator
SPYKS030_RS05175	COG1012	belongs to the aldehyde dehydrogenase family
SPYKS030_RS05190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYKS030_RS05220	COG0285	dihydrofolate synthase activity
SPYKS030_RS05255	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYKS030_RS05260	COG1177	transmembrane transport
SPYKS030_RS05270	COG4565	transcriptional regulatory protein
SPYKS030_RS05275	COG3290	protein histidine kinase activity
SPYKS030_RS05280	COG3493	citrate carrier protein
SPYKS030_RS05295	COG3700	Belongs to the class B bacterial acid phosphatase family
SPYKS030_RS05300	COG0038	chloride channel
SPYKS030_RS05310	COG0628	permease
SPYKS030_RS05335	COG1104	cysteine desulfurase activity
SPYKS030_RS05350	COG2357	RelA SpoT domain protein
SPYKS030_RS05360	COG0564	pseudouridine synthase activity
SPYKS030_RS05365	COG0280	phosphate acetyltransferase
SPYKS030_RS05385	COG1174	glycine betaine transport
SPYKS030_RS05405	COG2233	PERMEase
SPYKS030_RS05430	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYKS030_RS05465	COG1132	(ABC) transporter
SPYKS030_RS05485	COG3764	Sortase (surface protein transpeptidase)
SPYKS030_RS05490	COG0346	lactoylglutathione lyase activity
SPYKS030_RS05510	COG1272	protein, Hemolysin III
SPYKS030_RS05530	COG0758	DNA mediated transformation
SPYKS030_RS05535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYKS030_RS05555	COG0511	ligase activity, forming carbon-carbon bonds
SPYKS030_RS05560	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYKS030_RS05575	COG2851	Citrate transporter
SPYKS030_RS05585	COG0511	ligase activity, forming carbon-carbon bonds
SPYKS030_RS05590	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYKS030_RS05620	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYKS030_RS05640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYKS030_RS05650	COG2188	Transcriptional regulator
SPYKS030_RS05670	COG0488	(ABC) transporter
SPYKS030_RS05680	COG0352	thiamine-phosphate diphosphorylase activity
SPYKS030_RS05680	COG0351	phosphomethylpyrimidine kinase
SPYKS030_RS05685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYKS030_RS05690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYKS030_RS05690	COG1328	CTP reductase activity
SPYKS030_RS05695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYKS030_RS05725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYKS030_RS05745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYKS030_RS05750	COG4684	Psort location CytoplasmicMembrane, score
SPYKS030_RS05755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYKS030_RS05760	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYKS030_RS05765	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYKS030_RS05770	COG3845	ABC transporter
SPYKS030_RS05775	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYKS030_RS05780	COG0295	cytidine deaminase activity
SPYKS030_RS05785	COG2813	Specifically methylates the guanine in position
SPYKS030_RS05800	COG5002	protein histidine kinase activity
SPYKS030_RS05805	COG0745	RESPONSE REGULATOR receiver
SPYKS030_RS05820	COG0704	Plays a role in the regulation of phosphate uptake
SPYKS030_RS05835	COG0581	inorganic phosphate transmembrane transporter activity
SPYKS030_RS05840	COG0573	inorganic phosphate transmembrane transporter activity
SPYKS030_RS05850	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYKS030_RS05850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYKS030_RS05855	COG0483	inositol monophosphate 1-phosphatase activity
SPYKS030_RS05870	COG0196	riboflavin kinase activity
SPYKS030_RS05900	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYKS030_RS05900	COG1136	(ABC) transporter
SPYKS030_RS05950	COG1115	amino acid carrier protein
SPYKS030_RS05955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYKS030_RS05965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYKS030_RS05970	COG1126	abc transporter atp-binding protein
SPYKS030_RS05975	COG0765	amino acid transport
SPYKS030_RS05980	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYKS030_RS05995	COG0469	pyruvate kinase activity
SPYKS030_RS06010	COG1725	Transcriptional regulator
SPYKS030_RS06015	COG1131	(ABC) transporter
SPYKS030_RS06045	COG3177	Filamentation induced by cAMP protein fic
SPYKS030_RS06050	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYKS030_RS06050	COG1388	LysM domain
SPYKS030_RS06140	COG0740	serine-type endopeptidase activity
SPYKS030_RS06185	COG0582	viral genome integration into host DNA
SPYKS030_RS06255	COG0305	Participates in initiation and elongation during chromosome replication
SPYKS030_RS06320	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPYKS030_RS06325	COG1518	maintenance of DNA repeat elements
SPYKS030_RS06340	COG0647	UMP catabolic process
SPYKS030_RS06350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYKS030_RS06370	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYKS030_RS06375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYKS030_RS06380	COG3442	glutamine amidotransferase
SPYKS030_RS06385	COG0095	Lipoate-protein ligase
SPYKS030_RS06390	COG5492	domain, Protein
SPYKS030_RS06410	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYKS030_RS06415	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYKS030_RS06415	COG0022	dehydrogenase e1 component
SPYKS030_RS06420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYKS030_RS06425	COG0488	(ABC) transporter
SPYKS030_RS06445	COG1129	ABC transporter
SPYKS030_RS06465	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYKS030_RS06470	COG0457	Tetratricopeptide repeat
SPYKS030_RS06475	COG0628	permease
SPYKS030_RS06480	COG1051	belongs to the nudix hydrolase family
SPYKS030_RS06485	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYKS030_RS06495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYKS030_RS06500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYKS030_RS06510	COG2384	SAM-dependent methyltransferase
SPYKS030_RS06515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYKS030_RS06530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYKS030_RS06530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYKS030_RS06535	COG0300	oxidoreductase activity
SPYKS030_RS06545	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYKS030_RS06550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYKS030_RS06595	COG0539	negative regulation of cytoplasmic translation
SPYKS030_RS06615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYKS030_RS06625	COG0187	DNA topoisomerase II activity
SPYKS030_RS06645	COG0765	amino acid transport
SPYKS030_RS06650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYKS030_RS06675	COG0583	DNA-binding transcription factor activity
SPYKS030_RS06735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYKS030_RS06745	COG3425	synthase
SPYKS030_RS06780	COG0745	RESPONSE REGULATOR receiver
SPYKS030_RS06785	COG2357	RelA SpoT domain protein
SPYKS030_RS06790	COG0737	Belongs to the 5'-nucleotidase family
SPYKS030_RS06795	COG0242	peptide deformylase activity
SPYKS030_RS06810	COG0488	(ABC) transporter
SPYKS030_RS06830	COG0105	UTP biosynthetic process
SPYKS030_RS06855	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYKS030_RS06855	COG1388	LysM domain
SPYKS030_RS06860	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYKS030_RS06860	COG1388	LysM domain
SPYKS030_RS06865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYKS030_RS06865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYKS030_RS06865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYKS030_RS06870	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYKS030_RS06875	COG1349	DNA-binding transcription factor activity
SPYKS030_RS06925	COG1837	Belongs to the UPF0109 family
SPYKS030_RS06935	COG0584	glycerophosphoryl diester phosphodiesterase
SPYKS030_RS06940	COG0577	efflux transmembrane transporter activity
SPYKS030_RS06945	COG1136	(ABC) transporter
SPYKS030_RS06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYKS030_RS06985	COG0564	pseudouridine synthase activity
SPYKS030_RS06995	COG0583	DNA-binding transcription factor activity
SPYKS030_RS07005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYKS030_RS07030	COG1104	cysteine desulfurase activity
SPYKS030_RS07040	COG0285	dihydrofolate synthase activity
SPYKS030_RS07045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYKS030_RS07065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYKS030_RS07070	COG1368	sulfuric ester hydrolase activity
SPYKS030_RS07130	COG1216	Glycosyl transferase, family 2
SPYKS030_RS07175	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYKS030_RS07180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYKS030_RS07185	COG0358	DNA primase activity
SPYKS030_RS07190	COG1970	mechanosensitive ion channel activity
SPYKS030_RS07200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYKS030_RS07225	COG0577	efflux transmembrane transporter activity
SPYKS030_RS07310	COG1597	lipid kinase activity
SPYKS030_RS07320	COG4708	membrane
SPYKS030_RS07345	COG1131	(ABC) transporter
SPYKS030_RS07420	COG0038	chloride channel
SPYKS030_RS07430	COG0716	FMN binding
SPYKS030_RS07435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYKS030_RS07445	COG2222	sugar isomerase
SPYKS030_RS07450	COG2188	Transcriptional regulator
SPYKS030_RS07485	COG0436	Aminotransferase
SPYKS030_RS07490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYKS030_RS07490	COG1199	ATP-dependent helicase activity
SPYKS030_RS07505	COG2177	Part of the ABC transporter FtsEX involved in
SPYKS030_RS07510	COG2884	Cell division ATP-binding protein ftsE
SPYKS030_RS07520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYKS030_RS07530	COG0546	phosphoglycolate phosphatase activity
SPYKS030_RS07535	COG0800	Aldolase
SPYKS030_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
SPYKS030_RS07565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYKS030_RS07570	COG3715	PTS system
SPYKS030_RS07575	COG3716	PTS system mannose fructose sorbose family IID component
SPYKS030_RS07585	COG1609	Transcriptional regulator
SPYKS030_RS07600	COG1078	dGTPase activity
SPYKS030_RS07635	COG0772	Belongs to the SEDS family
SPYKS030_RS07645	COG1164	Oligoendopeptidase f
SPYKS030_RS07650	COG0386	Belongs to the glutathione peroxidase family
SPYKS030_RS07695	COG4443	Transcriptional Coactivator p15 (PC4)
SPYKS030_RS07700	COG0826	peptidase U32
SPYKS030_RS07745	COG2183	response to ionizing radiation
SPYKS030_RS07755	COG0701	Predicted permease
SPYKS030_RS07760	COG3689	TIGRFAM TIGR03943 family protein
SPYKS030_RS07770	COG1263	PTS System
SPYKS030_RS07770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYKS030_RS07770	COG2190	(PTS) system
SPYKS030_RS07775	COG3711	transcriptional antiterminator
SPYKS030_RS07780	COG0477	Major facilitator Superfamily
SPYKS030_RS07785	COG0552	protein localization to endoplasmic reticulum
SPYKS030_RS07790	COG0561	phosphatase activity
SPYKS030_RS07795	COG0561	phosphatase activity
SPYKS030_RS07900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYKS030_RS07910	COG1196	nuclear chromosome segregation
SPYKS030_RS07920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYKS030_RS07925	COG5002	protein histidine kinase activity
SPYKS030_RS07930	COG0745	RESPONSE REGULATOR receiver
SPYKS030_RS07945	COG0183	Belongs to the thiolase family
SPYKS030_RS07965	COG4555	ABC transporter
SPYKS030_RS07975	COG0438	transferase activity, transferring glycosyl groups
SPYKS030_RS07985	COG1609	Transcriptional regulator
SPYKS030_RS07990	COG0006	proline dipeptidase activity
SPYKS030_RS07995	COG0778	Nitroreductase
SPYKS030_RS08005	COG0463	Glycosyl transferase, family 2
SPYKS030_RS08035	COG0557	exoribonuclease II activity
SPYKS030_RS08050	COG2814	Major facilitator Superfamily
SPYKS030_RS08055	COG0433	COG0433 Predicted ATPase
SPYKS030_RS08145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYKS030_RS08155	COG1573	uracil-dna glycosylase
SPYKS030_RS08160	COG1702	phosphate starvation-inducible protein PhoH
SPYKS030_RS08250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYKS030_RS08260	COG0494	nUDIX hydrolase
SPYKS030_RS08275	COG0673	inositol 2-dehydrogenase activity
SPYKS030_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
SPYKS030_RS08345	COG1304	FMN binding
SPYKS030_RS08355	COG0708	Exodeoxyribonuclease III
SPYKS030_RS08360	COG1393	Belongs to the ArsC family
SPYKS030_RS08390	COG0470	DNA polymerase III
SPYKS030_RS08425	COG2244	polysaccharide biosynthetic process
SPYKS030_RS08435	COG1120	ATPase activity
SPYKS030_RS08440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYKS030_RS08445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYKS030_RS08450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYKS030_RS08465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYKS030_RS08470	COG1253	flavin adenine dinucleotide binding
SPYKS030_RS08475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYKS030_RS08480	COG1242	4 iron, 4 sulfur cluster binding
SPYKS030_RS08485	COG0671	phosphoesterase, PA-phosphatase related
SPYKS030_RS08490	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYKS030_RS08505	COG1187	pseudouridine synthase activity
SPYKS030_RS08560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYKS030_RS08565	COG1254	Belongs to the acylphosphatase family
SPYKS030_RS08580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYKS030_RS08600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYKS030_RS08610	COG1484	DNA-dependent DNA replication
SPYKS030_RS08630	COG0745	RESPONSE REGULATOR receiver
SPYKS030_RS08645	COG1704	LemA family
SPYKS030_RS08655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYKS030_RS08660	COG0569	domain protein
SPYKS030_RS08670	COG1114	Component of the transport system for branched-chain amino acids
SPYKS030_RS08685	COG1464	Belongs to the NlpA lipoprotein family
SPYKS030_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYKS030_RS08710	COG2226	methyltransferase
SPYKS030_RS08715	COG0799	negative regulation of ribosome biogenesis
SPYKS030_RS08720	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYKS030_RS08730	COG1534	Rna-binding protein
SPYKS030_RS08735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYKS030_RS08740	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYKS030_RS08750	COG5433	transposase activity
SPYKS030_RS08790	COG1929	Belongs to the glycerate kinase type-1 family
SPYKS030_RS08795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYKS030_RS08830	COG1136	(ABC) transporter
SPYKS030_RS08860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYKS030_RS08860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYKS030_RS08865	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYKS030_RS08915	COG4974	Belongs to the 'phage' integrase family
SPYKS030_RS08930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYKS030_RS08935	COG1476	TRANSCRIPTIONal
SPYKS030_RS08965	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYKS030_RS08985	COG1045	serine acetyltransferase
SPYKS030_RS09000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYKS030_RS09015	COG3711	transcriptional antiterminator
SPYKS030_RS09040	COG0431	NADPH-dependent FMN reductase
SPYKS030_RS09045	COG1846	Transcriptional regulator
SPYKS030_RS09065	COG4589	Belongs to the CDS family
SPYKS030_RS09075	COG1862	Preprotein translocase
SPYKS030_RS09085	COG1523	belongs to the glycosyl hydrolase 13 family
SPYKS030_RS09100	COG3842	ATPase activity
SPYKS030_RS09130	COG5433	transposase activity
SPYKS030_RS09145	COG1263	PTS System
SPYKS030_RS09145	COG2190	(PTS) system
SPYKS030_RS09145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYKS030_RS09150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYKS030_RS09165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYKS030_RS09170	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYKS030_RS09175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYKS030_RS09200	COG0601	transmembrane transport
SPYKS030_RS09230	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYKS030_RS09240	COG1196	nuclear chromosome segregation
SPYKS030_RS09245	COG3711	transcriptional antiterminator
SPYKS030_RS09260	COG3942	CHAP domain
SPYKS030_RS09260	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYKS030_RS09265	COG2205	protein histidine kinase activity
SPYKS030_RS09270	COG0745	RESPONSE REGULATOR receiver
SPYKS030_RS09275	COG0577	efflux transmembrane transporter activity
SPYKS030_RS09280	COG1136	(ABC) transporter
SPYKS030_RS09345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYKS030_RS09360	COG1882	Formate acetyltransferase
SPYKS030_RS09365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYKS030_RS09370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYKS030_RS09375	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYKS030_RS09380	COG2390	Transcriptional regulator
SPYKS030_RS09385	COG1349	DNA-binding transcription factor activity
SPYKS030_RS09390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYKS030_RS09410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYKS030_RS09425	COG0564	pseudouridine synthase activity
SPYKS030_RS09460	COG0542	response to heat
SPYKS030_RS09465	COG4463	regulation of RNA biosynthetic process
SPYKS030_RS09480	COG0450	alkyl hydroperoxide reductase
SPYKS030_RS09495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYKS030_RS09505	COG3404	Formiminotransferase-cyclodeaminase
SPYKS030_RS09520	COG0531	amino acid
SPYKS030_RS09550	COG3590	peptidase
SPYKS030_RS09555	COG0366	Alpha amylase catalytic
SPYKS030_RS09560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYKS030_RS09560	COG1263	PTS System
SPYKS030_RS09565	COG2188	Transcriptional regulator
SPYKS030_RS09580	COG2514	catechol 2,3-dioxygenase activity
SPYKS030_RS09590	COG0602	queuosine metabolic process
SPYKS030_RS09605	COG1328	CTP reductase activity
SPYKS030_RS09630	COG1393	Belongs to the ArsC family
SPYKS030_RS09645	COG0519	Catalyzes the synthesis of GMP from XMP
SPYKS030_RS09690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYKS030_RS09695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYKS030_RS09700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYKS030_RS09785	COG1511	domain protein
SPYKS030_RS09805	COG0305	Participates in initiation and elongation during chromosome replication
SPYKS030_RS09835	COG1760	l-serine dehydratase
SPYKS030_RS09840	COG1760	l-serine dehydratase
SPYKS030_RS09845	COG0741	lytic transglycosylase activity
SPYKS030_RS09850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYKS030_RS09865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYKS030_RS09875	COG0612	Peptidase, M16
SPYKS030_RS09930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYKS030_RS09935	COG0488	(ABC) transporter
SPYKS030_RS09970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYKS030_RS09975	COG1475	DNA binding