locus-tag	class	description
M1GAS476_RS00010	COG0592	DNA-directed DNA polymerase activity
M1GAS476_RS00020	COG0012	GTP binding
M1GAS476_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1GAS476_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1GAS476_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1GAS476_RS00065	COG0531	amino acid
M1GAS476_RS00175	COG3942	CHAP domain
M1GAS476_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1GAS476_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1GAS476_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1GAS476_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1GAS476_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1GAS476_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1GAS476_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
M1GAS476_RS00285	COG1454	alcohol dehydrogenase
M1GAS476_RS00290	COG1064	alcohol dehydrogenase
M1GAS476_RS00295	COG0534	Mate efflux family protein
M1GAS476_RS00405	COG0201	protein transport
M1GAS476_RS00540	COG1121	(ABC) transporter
M1GAS476_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1GAS476_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1GAS476_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1GAS476_RS00585	COG1459	type II secretion system
M1GAS476_RS00590	COG4537	Required for transformation and DNA binding
M1GAS476_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1GAS476_RS00635	COG1363	Peptidase, m42
M1GAS476_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1GAS476_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1GAS476_RS00660	COG1428	Deoxynucleoside kinase
M1GAS476_RS00665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1GAS476_RS00695	COG4509	Sortase family
M1GAS476_RS00705	COG4372	Transposase
M1GAS476_RS00730	COG2031	fatty acid transporter
M1GAS476_RS00750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1GAS476_RS00765	COG0251	oxidation-reduction process
M1GAS476_RS00780	COG1269	ATP hydrolysis coupled proton transport
M1GAS476_RS00785	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1GAS476_RS00795	COG1527	subunit (C
M1GAS476_RS00800	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M1GAS476_RS00835	COG1744	ABC transporter substrate-binding protein PnrA-like
M1GAS476_RS00875	COG0626	cystathionine gamma-synthase activity
M1GAS476_RS00905	COG3623	hexulose-6-phosphate isomerase
M1GAS476_RS00925	COG4175	Glycine betaine
M1GAS476_RS00925	COG3448	diguanylate cyclase activity
M1GAS476_RS00935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1GAS476_RS00935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1GAS476_RS00955	COG3969	phosphoadenosine phosphosulfate
M1GAS476_RS00960	COG1475	DNA binding
M1GAS476_RS00970	COG2801	Transposase and inactivated derivatives
M1GAS476_RS00975	COG2801	Transposase and inactivated derivatives
M1GAS476_RS00990	COG0157	Belongs to the NadC ModD family
M1GAS476_RS00995	COG2801	Transposase and inactivated derivatives
M1GAS476_RS01015	COG1268	BioY protein
M1GAS476_RS01020	COG1234	tRNA 3'-trailer cleavage
M1GAS476_RS01060	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1GAS476_RS01080	COG1122	ATPase activity
M1GAS476_RS01090	COG0601	transmembrane transport
M1GAS476_RS01125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1GAS476_RS01130	COG0512	Glutamine amidotransferase of anthranilate synthase
M1GAS476_RS01135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1GAS476_RS01150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1GAS476_RS01155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1GAS476_RS01155	COG2190	(PTS) system
M1GAS476_RS01155	COG1263	PTS System
M1GAS476_RS01195	COG3842	ATPase activity
M1GAS476_RS01205	COG1523	belongs to the glycosyl hydrolase 13 family
M1GAS476_RS01215	COG1862	Preprotein translocase
M1GAS476_RS01225	COG4589	Belongs to the CDS family
M1GAS476_RS01245	COG1846	Transcriptional regulator
M1GAS476_RS01270	COG3711	transcriptional antiterminator
M1GAS476_RS01280	COG3037	sugar-specific permease SgaT UlaA
M1GAS476_RS01285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1GAS476_RS01300	COG1045	serine acetyltransferase
M1GAS476_RS01315	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M1GAS476_RS01325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1GAS476_RS01345	COG1476	TRANSCRIPTIONal
M1GAS476_RS01350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1GAS476_RS01400	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1GAS476_RS01405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1GAS476_RS01405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1GAS476_RS01430	COG1136	(ABC) transporter
M1GAS476_RS01435	COG0577	efflux transmembrane transporter activity
M1GAS476_RS01465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M1GAS476_RS01470	COG1929	Belongs to the glycerate kinase type-1 family
M1GAS476_RS01510	COG5433	transposase activity
M1GAS476_RS01520	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M1GAS476_RS01525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M1GAS476_RS01530	COG1534	Rna-binding protein
M1GAS476_RS01540	COG1713	HD superfamily hydrolase involved in NAD metabolism
M1GAS476_RS01545	COG0799	negative regulation of ribosome biogenesis
M1GAS476_RS01550	COG2226	methyltransferase
M1GAS476_RS01565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1GAS476_RS01570	COG1464	Belongs to the NlpA lipoprotein family
M1GAS476_RS01585	COG1114	Component of the transport system for branched-chain amino acids
M1GAS476_RS01595	COG0569	domain protein
M1GAS476_RS01600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1GAS476_RS01610	COG1704	LemA family
M1GAS476_RS01625	COG0745	RESPONSE REGULATOR receiver
M1GAS476_RS01645	COG1484	DNA-dependent DNA replication
M1GAS476_RS01655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1GAS476_RS01675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1GAS476_RS01690	COG1254	Belongs to the acylphosphatase family
M1GAS476_RS01700	COG5433	transposase activity
M1GAS476_RS01705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1GAS476_RS01760	COG1187	pseudouridine synthase activity
M1GAS476_RS01785	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M1GAS476_RS01790	COG0671	phosphoesterase, PA-phosphatase related
M1GAS476_RS01795	COG1242	4 iron, 4 sulfur cluster binding
M1GAS476_RS01800	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M1GAS476_RS01805	COG1253	flavin adenine dinucleotide binding
M1GAS476_RS01810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M1GAS476_RS01825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1GAS476_RS01830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1GAS476_RS01835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1GAS476_RS01840	COG1120	ATPase activity
M1GAS476_RS01850	COG2244	polysaccharide biosynthetic process
M1GAS476_RS01875	COG0470	DNA polymerase III
M1GAS476_RS01910	COG1393	Belongs to the ArsC family
M1GAS476_RS01915	COG0708	Exodeoxyribonuclease III
M1GAS476_RS01925	COG1304	FMN binding
M1GAS476_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
M1GAS476_RS02010	COG0673	inositol 2-dehydrogenase activity
M1GAS476_RS02025	COG0494	nUDIX hydrolase
M1GAS476_RS02035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1GAS476_RS02125	COG1702	phosphate starvation-inducible protein PhoH
M1GAS476_RS02130	COG1573	uracil-dna glycosylase
M1GAS476_RS02140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M1GAS476_RS02220	COG0433	COG0433 Predicted ATPase
M1GAS476_RS02225	COG2814	Major facilitator Superfamily
M1GAS476_RS02235	COG0557	exoribonuclease II activity
M1GAS476_RS02265	COG0463	Glycosyl transferase, family 2
M1GAS476_RS02275	COG0778	Nitroreductase
M1GAS476_RS02280	COG0006	proline dipeptidase activity
M1GAS476_RS02285	COG1609	Transcriptional regulator
M1GAS476_RS02295	COG0438	transferase activity, transferring glycosyl groups
M1GAS476_RS02305	COG4555	ABC transporter
M1GAS476_RS02325	COG0183	Belongs to the thiolase family
M1GAS476_RS02340	COG0745	RESPONSE REGULATOR receiver
M1GAS476_RS02345	COG5002	protein histidine kinase activity
M1GAS476_RS02350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M1GAS476_RS02360	COG1196	nuclear chromosome segregation
M1GAS476_RS02370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M1GAS476_RS02450	COG4695	Portal protein
M1GAS476_RS02500	COG0561	phosphatase activity
M1GAS476_RS02505	COG0561	phosphatase activity
M1GAS476_RS02510	COG0552	protein localization to endoplasmic reticulum
M1GAS476_RS02515	COG0477	Major facilitator Superfamily
M1GAS476_RS02520	COG3711	transcriptional antiterminator
M1GAS476_RS02525	COG1263	PTS System
M1GAS476_RS02525	COG2190	(PTS) system
M1GAS476_RS02525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1GAS476_RS02535	COG3689	TIGRFAM TIGR03943 family protein
M1GAS476_RS02540	COG0701	Predicted permease
M1GAS476_RS02550	COG2183	response to ionizing radiation
M1GAS476_RS02595	COG0826	peptidase U32
M1GAS476_RS02600	COG4443	Transcriptional Coactivator p15 (PC4)
M1GAS476_RS02650	COG0386	Belongs to the glutathione peroxidase family
M1GAS476_RS02655	COG1164	Oligoendopeptidase f
M1GAS476_RS02665	COG0772	Belongs to the SEDS family
M1GAS476_RS02700	COG1078	dGTPase activity
M1GAS476_RS02715	COG1609	Transcriptional regulator
M1GAS476_RS02725	COG3716	PTS system mannose fructose sorbose family IID component
M1GAS476_RS02730	COG3715	PTS system
M1GAS476_RS02735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1GAS476_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
M1GAS476_RS02765	COG0800	Aldolase
M1GAS476_RS02770	COG0546	phosphoglycolate phosphatase activity
M1GAS476_RS02775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1GAS476_RS02785	COG2884	Cell division ATP-binding protein ftsE
M1GAS476_RS02790	COG2177	Part of the ABC transporter FtsEX involved in
M1GAS476_RS02805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1GAS476_RS02805	COG1199	ATP-dependent helicase activity
M1GAS476_RS02810	COG0436	Aminotransferase
M1GAS476_RS02845	COG2188	Transcriptional regulator
M1GAS476_RS02850	COG2222	sugar isomerase
M1GAS476_RS02860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1GAS476_RS02865	COG0716	FMN binding
M1GAS476_RS02875	COG0038	chloride channel
M1GAS476_RS02965	COG1131	(ABC) transporter
M1GAS476_RS02985	COG4708	membrane
M1GAS476_RS02995	COG1597	lipid kinase activity
M1GAS476_RS03080	COG0577	efflux transmembrane transporter activity
M1GAS476_RS03090	COG2321	neutral zinc metallopeptidase
M1GAS476_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1GAS476_RS03115	COG1970	mechanosensitive ion channel activity
M1GAS476_RS03120	COG0358	DNA primase activity
M1GAS476_RS03125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1GAS476_RS03130	COG2151	metal-sulfur cluster biosynthetic enzyme
M1GAS476_RS03175	COG1216	Glycosyl transferase, family 2
M1GAS476_RS03230	COG1368	sulfuric ester hydrolase activity
M1GAS476_RS03235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M1GAS476_RS03255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1GAS476_RS03260	COG0285	dihydrofolate synthase activity
M1GAS476_RS03270	COG1104	cysteine desulfurase activity
M1GAS476_RS03295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M1GAS476_RS03300	COG0583	DNA-binding transcription factor activity
M1GAS476_RS03310	COG0564	pseudouridine synthase activity
M1GAS476_RS03340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1GAS476_RS03345	COG1136	(ABC) transporter
M1GAS476_RS03350	COG0577	efflux transmembrane transporter activity
M1GAS476_RS03355	COG0584	glycerophosphoryl diester phosphodiesterase
M1GAS476_RS03365	COG1837	Belongs to the UPF0109 family
M1GAS476_RS03415	COG1349	DNA-binding transcription factor activity
M1GAS476_RS03420	COG1105	Belongs to the carbohydrate kinase PfkB family
M1GAS476_RS03425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1GAS476_RS03425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1GAS476_RS03425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1GAS476_RS03430	COG1705	Flagellar rod assembly protein muramidase FlgJ
M1GAS476_RS03430	COG1388	LysM domain
M1GAS476_RS03435	COG1705	Flagellar rod assembly protein muramidase FlgJ
M1GAS476_RS03435	COG1388	LysM domain
M1GAS476_RS03440	COG2801	Transposase and inactivated derivatives
M1GAS476_RS03455	COG0105	UTP biosynthetic process
M1GAS476_RS03475	COG0488	(ABC) transporter
M1GAS476_RS03485	COG0242	peptide deformylase activity
M1GAS476_RS03490	COG0737	Belongs to the 5'-nucleotidase family
M1GAS476_RS03495	COG2357	RelA SpoT domain protein
M1GAS476_RS03500	COG0745	RESPONSE REGULATOR receiver
M1GAS476_RS03535	COG3425	synthase
M1GAS476_RS03545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1GAS476_RS03605	COG0583	DNA-binding transcription factor activity
M1GAS476_RS03630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1GAS476_RS03635	COG0765	amino acid transport
M1GAS476_RS03655	COG0187	DNA topoisomerase II activity
M1GAS476_RS03665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1GAS476_RS03685	COG0539	negative regulation of cytoplasmic translation
M1GAS476_RS03720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1GAS476_RS03725	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M1GAS476_RS03735	COG0300	oxidoreductase activity
M1GAS476_RS03740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1GAS476_RS03740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M1GAS476_RS03755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1GAS476_RS03760	COG2384	SAM-dependent methyltransferase
M1GAS476_RS03770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1GAS476_RS03775	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1GAS476_RS03785	COG1088	dTDP-glucose 4,6-dehydratase activity
M1GAS476_RS03790	COG1051	belongs to the nudix hydrolase family
M1GAS476_RS03795	COG0628	permease
M1GAS476_RS03800	COG0457	Tetratricopeptide repeat
M1GAS476_RS03805	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M1GAS476_RS03820	COG1129	ABC transporter
M1GAS476_RS03840	COG0488	(ABC) transporter
M1GAS476_RS03845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1GAS476_RS03850	COG0022	dehydrogenase e1 component
M1GAS476_RS03850	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1GAS476_RS03870	COG5492	domain, Protein
M1GAS476_RS03875	COG0095	Lipoate-protein ligase
M1GAS476_RS03880	COG3442	glutamine amidotransferase
M1GAS476_RS03885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1GAS476_RS03890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M1GAS476_RS03910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1GAS476_RS03920	COG0647	UMP catabolic process
M1GAS476_RS03935	COG1518	maintenance of DNA repeat elements
M1GAS476_RS03940	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M1GAS476_RS03955	COG0105	UTP biosynthetic process
M1GAS476_RS03990	COG3715	PTS system
M1GAS476_RS03995	COG3716	PTS system mannose fructose sorbose family IID component
M1GAS476_RS04000	COG2972	Histidine kinase
M1GAS476_RS04005	COG4753	response regulator
M1GAS476_RS04005	COG2207	Transcriptional regulator
M1GAS476_RS04010	COG1840	ABC-type Fe3 transport system, periplasmic component
M1GAS476_RS04025	COG1011	Hydrolase
M1GAS476_RS04030	COG1012	belongs to the aldehyde dehydrogenase family
M1GAS476_RS04045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1GAS476_RS04105	COG1131	(ABC) transporter
M1GAS476_RS04120	COG1396	sequence-specific DNA binding
M1GAS476_RS04160	COG0285	dihydrofolate synthase activity
M1GAS476_RS04180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1GAS476_RS04195	COG1176	ABC-type spermidine putrescine transport system, permease component I
M1GAS476_RS04200	COG1177	transmembrane transport
M1GAS476_RS04210	COG4565	transcriptional regulatory protein
M1GAS476_RS04215	COG3290	protein histidine kinase activity
M1GAS476_RS04220	COG3493	citrate carrier protein
M1GAS476_RS04235	COG3700	Belongs to the class B bacterial acid phosphatase family
M1GAS476_RS04240	COG0038	chloride channel
M1GAS476_RS04250	COG0628	permease
M1GAS476_RS04260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M1GAS476_RS04275	COG1104	cysteine desulfurase activity
M1GAS476_RS04285	COG4116	CYTH
M1GAS476_RS04290	COG2357	RelA SpoT domain protein
M1GAS476_RS04300	COG0564	pseudouridine synthase activity
M1GAS476_RS04305	COG0280	phosphate acetyltransferase
M1GAS476_RS04325	COG1174	glycine betaine transport
M1GAS476_RS04340	COG2233	PERMEase
M1GAS476_RS04365	COG2890	protein-(glutamine-N5) methyltransferase activity
M1GAS476_RS04395	COG1132	(ABC) transporter
M1GAS476_RS04400	COG1132	(ABC) transporter
M1GAS476_RS04420	COG3764	Sortase (surface protein transpeptidase)
M1GAS476_RS04425	COG0346	lactoylglutathione lyase activity
M1GAS476_RS04440	COG1272	protein, Hemolysin III
M1GAS476_RS04460	COG0758	DNA mediated transformation
M1GAS476_RS04465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1GAS476_RS04510	COG0511	ligase activity, forming carbon-carbon bonds
M1GAS476_RS04515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M1GAS476_RS04530	COG2851	Citrate transporter
M1GAS476_RS04540	COG0511	ligase activity, forming carbon-carbon bonds
M1GAS476_RS04545	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M1GAS476_RS04580	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
M1GAS476_RS04600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1GAS476_RS04610	COG2188	Transcriptional regulator
M1GAS476_RS04630	COG0488	(ABC) transporter
M1GAS476_RS04640	COG0352	thiamine-phosphate diphosphorylase activity
M1GAS476_RS04640	COG0351	phosphomethylpyrimidine kinase
M1GAS476_RS04645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1GAS476_RS04650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1GAS476_RS04650	COG1328	CTP reductase activity
M1GAS476_RS04655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1GAS476_RS04685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1GAS476_RS04705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1GAS476_RS04710	COG4684	Psort location CytoplasmicMembrane, score
M1GAS476_RS04715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1GAS476_RS04720	COG1079	Belongs to the binding-protein-dependent transport system permease family
M1GAS476_RS04725	COG4603	Belongs to the binding-protein-dependent transport system permease family
M1GAS476_RS04730	COG3845	ABC transporter
M1GAS476_RS04735	COG1744	ABC transporter substrate-binding protein PnrA-like
M1GAS476_RS04740	COG0295	cytidine deaminase activity
M1GAS476_RS04745	COG2813	Specifically methylates the guanine in position
M1GAS476_RS04760	COG5002	protein histidine kinase activity
M1GAS476_RS04765	COG0745	RESPONSE REGULATOR receiver
M1GAS476_RS04775	COG0704	Plays a role in the regulation of phosphate uptake
M1GAS476_RS04790	COG0581	inorganic phosphate transmembrane transporter activity
M1GAS476_RS04795	COG0573	inorganic phosphate transmembrane transporter activity
M1GAS476_RS04805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1GAS476_RS04805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M1GAS476_RS04810	COG0483	inositol monophosphate 1-phosphatase activity
M1GAS476_RS04825	COG0196	riboflavin kinase activity
M1GAS476_RS04855	COG1136	(ABC) transporter
M1GAS476_RS04855	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1GAS476_RS04905	COG1115	amino acid carrier protein
M1GAS476_RS04910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1GAS476_RS04920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1GAS476_RS04925	COG1126	abc transporter atp-binding protein
M1GAS476_RS04930	COG0765	amino acid transport
M1GAS476_RS04935	COG2824	Alkylphosphonate utilization operon protein PhnA
M1GAS476_RS04950	COG0469	pyruvate kinase activity
M1GAS476_RS04965	COG1725	Transcriptional regulator
M1GAS476_RS04970	COG1131	(ABC) transporter
M1GAS476_RS05125	COG1783	phage Terminase large subunit
M1GAS476_RS05230	COG1396	sequence-specific DNA binding
M1GAS476_RS05270	COG0058	SHG alpha-glucan phosphorylase activity
M1GAS476_RS05275	COG1640	4-alpha-glucanotransferase
M1GAS476_RS05280	COG1609	Transcriptional regulator
M1GAS476_RS05285	COG2182	Extracellular solute-binding protein
M1GAS476_RS05290	COG1175	transmembrane transport
M1GAS476_RS05295	COG3833	ABC-type maltose transport systems, permease component
M1GAS476_RS05310	COG3833	ABC-type maltose transport systems, permease component
M1GAS476_RS05315	COG1175	transmembrane transport
M1GAS476_RS05325	COG0366	Alpha amylase catalytic
M1GAS476_RS05330	COG2182	Extracellular solute-binding protein
M1GAS476_RS05340	COG0657	acetylesterase activity
M1GAS476_RS05345	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M1GAS476_RS05355	COG1696	Membrane protein involved in D-alanine export
M1GAS476_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1GAS476_RS05380	COG1126	abc transporter atp-binding protein
M1GAS476_RS05385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1GAS476_RS05395	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1GAS476_RS05405	COG3711	transcriptional antiterminator
M1GAS476_RS05405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1GAS476_RS05415	COG2723	6-phospho-beta-galactosidase activity
M1GAS476_RS05440	COG2801	Transposase and inactivated derivatives
M1GAS476_RS05445	COG1187	pseudouridine synthase activity
M1GAS476_RS05455	COG2814	Major facilitator Superfamily
M1GAS476_RS05505	COG4109	DRTGG domain
M1GAS476_RS05535	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M1GAS476_RS05535	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M1GAS476_RS05540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1GAS476_RS05545	COG1956	GAF domain-containing protein
M1GAS476_RS05565	COG0513	Belongs to the DEAD box helicase family
M1GAS476_RS05570	COG0726	polysaccharide deacetylase
M1GAS476_RS05590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1GAS476_RS05595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1GAS476_RS05600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1GAS476_RS05615	COG2801	Transposase and inactivated derivatives
M1GAS476_RS05625	COG2801	Transposase and inactivated derivatives
M1GAS476_RS05640	COG1476	TRANSCRIPTIONal
M1GAS476_RS05655	COG4122	O-methyltransferase activity
M1GAS476_RS05660	COG2223	nitrite transmembrane transporter activity
M1GAS476_RS05675	COG1187	pseudouridine synthase activity
M1GAS476_RS05720	COG0658	competence protein
M1GAS476_RS05720	COG2333	competence protein COMEC
M1GAS476_RS05725	COG1596	polysaccharide export
M1GAS476_RS05725	COG1555	photosystem II stabilization
M1GAS476_RS05730	COG0204	Acyl-transferase
M1GAS476_RS05735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M1GAS476_RS05750	COG0513	Belongs to the DEAD box helicase family
M1GAS476_RS05765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1GAS476_RS05780	COG0768	penicillin binding
M1GAS476_RS05785	COG2116	formate transmembrane transporter activity
M1GAS476_RS05795	COG1827	regulation of RNA biosynthetic process
M1GAS476_RS05810	COG2217	Heavy metal translocating P-type atpase
M1GAS476_RS05995	COG3723	Recombinational DNA repair protein, rece pathway
M1GAS476_RS06015	COG3935	DnaD domain protein
M1GAS476_RS06050	COG3561	AntA/AntB antirepressor
M1GAS476_RS06060	COG1396	sequence-specific DNA binding
M1GAS476_RS06075	COG0582	viral genome integration into host DNA
M1GAS476_RS06090	COG2755	lipolytic protein G-D-S-L family
M1GAS476_RS06105	COG0497	DNA recombination
M1GAS476_RS06110	COG1438	arginine binding
M1GAS476_RS06115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M1GAS476_RS06140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1GAS476_RS06145	COG0415	Belongs to the DNA photolyase family
M1GAS476_RS06155	COG0765	amino acid transport
M1GAS476_RS06160	COG4703	Protein of unknown function (DUF1797)
M1GAS476_RS06165	COG0542	response to heat
M1GAS476_RS06170	COG0494	nUDIX hydrolase
M1GAS476_RS06185	COG3599	regulation of cell shape
M1GAS476_RS06190	COG2302	S4 RNA-binding domain
M1GAS476_RS06205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M1GAS476_RS06240	COG1217	gtp-binding protein TYPA
M1GAS476_RS06245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1GAS476_RS06250	COG1940	carbohydrate kinase activity
M1GAS476_RS06260	COG0783	Belongs to the Dps family
M1GAS476_RS06275	COG4470	Protein conserved in bacteria
M1GAS476_RS06285	COG3480	Lon protease (S16) C-terminal proteolytic domain
M1GAS476_RS06295	COG0742	ribosomal rna small subunit methyltransferase
M1GAS476_RS06305	COG0549	Belongs to the carbamate kinase family
M1GAS476_RS06310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1GAS476_RS06315	COG1288	antiporter activity
M1GAS476_RS06330	COG2235	arginine
M1GAS476_RS06355	COG2972	Histidine kinase
M1GAS476_RS06370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1GAS476_RS06375	COG0785	Cytochrome C biogenesis protein
M1GAS476_RS06380	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M1GAS476_RS06385	COG1518	maintenance of DNA repeat elements
M1GAS476_RS06445	COG1605	Chorismate mutase
M1GAS476_RS06445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M1GAS476_RS06465	COG2226	methyltransferase
M1GAS476_RS06475	COG3250	beta-galactosidase activity
M1GAS476_RS06480	COG2207	Transcriptional regulator
M1GAS476_RS06480	COG4753	response regulator
M1GAS476_RS06485	COG2972	Histidine kinase
M1GAS476_RS06495	COG1653	transport
M1GAS476_RS06500	COG0395	ABC-type sugar transport system, permease component
M1GAS476_RS06505	COG1175	transmembrane transport
M1GAS476_RS06510	COG1940	carbohydrate kinase activity
M1GAS476_RS06515	COG2723	6-phospho-beta-galactosidase activity
M1GAS476_RS06520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M1GAS476_RS06535	COG0383	alpha-mannosidase activity
M1GAS476_RS06625	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M1GAS476_RS06630	COG1739	Uncharacterized protein family UPF0029
M1GAS476_RS06640	COG1098	S1 RNA binding domain
M1GAS476_RS06650	COG2197	response regulator
M1GAS476_RS06655	COG4585	Histidine kinase
M1GAS476_RS06665	COG2815	serine threonine protein kinase
M1GAS476_RS06665	COG0515	serine threonine protein kinase
M1GAS476_RS06675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1GAS476_RS06675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1GAS476_RS06685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1GAS476_RS06705	COG0583	DNA-binding transcription factor activity
M1GAS476_RS06710	COG0183	Belongs to the thiolase family
M1GAS476_RS06715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1GAS476_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
M1GAS476_RS06730	COG2610	gluconate transmembrane transporter activity
M1GAS476_RS06745	COG0116	Belongs to the methyltransferase superfamily
M1GAS476_RS06765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1GAS476_RS06770	COG3579	cysteine-type endopeptidase activity
M1GAS476_RS06780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M1GAS476_RS06785	COG1113	amino acid transport
M1GAS476_RS06790	COG0492	ferredoxin-NADP+ reductase activity
M1GAS476_RS06800	COG1126	abc transporter atp-binding protein
M1GAS476_RS06810	COG0513	Belongs to the DEAD box helicase family
M1GAS476_RS06820	COG0768	penicillin binding
M1GAS476_RS06855	COG1131	(ABC) transporter
M1GAS476_RS06880	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1GAS476_RS06885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1GAS476_RS06920	COG1755	Isoprenylcysteine carboxyl methyltransferase
M1GAS476_RS06925	COG0656	L-ascorbic acid biosynthetic process
M1GAS476_RS06935	COG1283	sodium-dependent phosphate transmembrane transporter activity
M1GAS476_RS06955	COG0561	phosphatase activity
M1GAS476_RS06960	COG2860	membrane
M1GAS476_RS07010	COG2217	Heavy metal translocating P-type atpase
M1GAS476_RS07040	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M1GAS476_RS07045	COG0195	Participates in both transcription termination and antitermination
M1GAS476_RS07065	COG1705	Flagellar rod assembly protein muramidase FlgJ
M1GAS476_RS07185	COG1783	phage Terminase large subunit
M1GAS476_RS07300	COG4974	Belongs to the 'phage' integrase family
M1GAS476_RS07320	COG4473	ABC transporter
M1GAS476_RS07325	COG1131	(ABC) transporter
M1GAS476_RS07330	COG0537	adenosine 5'-monophosphoramidase activity
M1GAS476_RS07340	COG1316	TRANSCRIPTIONal
M1GAS476_RS07350	COG0802	atpase or kinase
M1GAS476_RS07355	COG2252	PERMEase
M1GAS476_RS07360	COG0561	phosphatase activity
M1GAS476_RS07370	COG3715	PTS system
M1GAS476_RS07375	COG3716	PTS system mannose fructose sorbose family IID component
M1GAS476_RS07400	COG0439	Biotin carboxylase
M1GAS476_RS07415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1GAS476_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
M1GAS476_RS07425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1GAS476_RS07450	COG1024	Enoyl-CoA hydratase
M1GAS476_RS07485	COG0588	phosphoglycerate mutase activity
M1GAS476_RS07490	COG2261	transglycosylase associated protein
M1GAS476_RS07515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1GAS476_RS07515	COG0574	Belongs to the PEP-utilizing enzyme family
M1GAS476_RS07520	COG1335	isochorismatase
M1GAS476_RS07530	COG0436	Aminotransferase
M1GAS476_RS07540	COG0561	phosphatase activity
M1GAS476_RS07545	COG0252	asparaginase activity
M1GAS476_RS07560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1GAS476_RS07565	COG1129	ABC transporter
M1GAS476_RS07580	COG1132	(ABC) transporter
M1GAS476_RS07585	COG4988	ABC transporter
M1GAS476_RS07590	COG1120	ATPase activity
M1GAS476_RS07615	COG3942	CHAP domain
M1GAS476_RS07615	COG1388	LysM domain
M1GAS476_RS07640	COG5433	transposase activity
M1GAS476_RS07645	COG1482	cell wall glycoprotein biosynthetic process
M1GAS476_RS07650	COG1940	carbohydrate kinase activity
M1GAS476_RS07660	COG1263	PTS System
M1GAS476_RS07660	COG2190	(PTS) system
M1GAS476_RS07660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1GAS476_RS07665	COG1621	beta-fructofuranosidase activity
M1GAS476_RS07670	COG1609	Transcriptional regulator
M1GAS476_RS07690	COG2131	deaminase
M1GAS476_RS07695	COG0006	proline dipeptidase activity
M1GAS476_RS07735	COG1194	a g-specific adenine glycosylase
M1GAS476_RS07745	COG3118	belongs to the thioredoxin family
M1GAS476_RS07775	COG0681	Belongs to the peptidase S26 family
M1GAS476_RS07780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1GAS476_RS07795	COG1882	Formate acetyltransferase
M1GAS476_RS07800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1GAS476_RS07815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1GAS476_RS07820	COG2814	Major facilitator Superfamily
M1GAS476_RS07825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1GAS476_RS07850	COG0789	Transcriptional regulator
M1GAS476_RS07865	COG2081	HI0933 family
M1GAS476_RS07875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1GAS476_RS07880	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M1GAS476_RS07900	COG0456	acetyltransferase
M1GAS476_RS07905	COG1214	PFAM Peptidase M22, glycoprotease
M1GAS476_RS07920	COG0174	glutamine synthetase
M1GAS476_RS07925	COG0789	Transcriptional regulator
M1GAS476_RS07940	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M1GAS476_RS07965	COG5433	transposase activity
M1GAS476_RS08005	COG0668	transmembrane transport
M1GAS476_RS08015	COG4720	Psort location CytoplasmicMembrane, score
M1GAS476_RS08020	COG0351	phosphomethylpyrimidine kinase
M1GAS476_RS08070	COG0444	Belongs to the ABC transporter superfamily
M1GAS476_RS08075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1GAS476_RS08080	COG0601	transmembrane transport
M1GAS476_RS08085	COG4166	transmembrane transport
M1GAS476_RS08090	COG1686	Belongs to the peptidase S11 family
M1GAS476_RS08095	COG1686	Belongs to the peptidase S11 family
M1GAS476_RS08110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1GAS476_RS08115	COG0719	Fe-S assembly protein
M1GAS476_RS08125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1GAS476_RS08145	COG0765	amino acid transport
M1GAS476_RS08180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1GAS476_RS08195	COG1564	THIamine pyrophosphokinase
M1GAS476_RS08220	COG0084	hydrolase, TatD family'
M1GAS476_RS08235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1GAS476_RS08245	COG0395	ABC-type sugar transport system, permease component
M1GAS476_RS08250	COG1175	transmembrane transport
M1GAS476_RS08270	COG1847	R3H domain protein
M1GAS476_RS08295	COG3290	protein histidine kinase activity
M1GAS476_RS08320	COG0756	dUTP diphosphatase activity
M1GAS476_RS08330	COG1132	(ABC) transporter
M1GAS476_RS08335	COG1132	(ABC) transporter
M1GAS476_RS08355	COG0457	Tetratricopeptide repeat
M1GAS476_RS08355	COG0705	Rhomboid family
M1GAS476_RS08370	COG5433	transposase activity
M1GAS476_RS08400	COG3711	transcriptional antiterminator
M1GAS476_RS08410	COG1705	Flagellar rod assembly protein muramidase FlgJ
M1GAS476_RS08410	COG3942	CHAP domain
M1GAS476_RS08415	COG2205	protein histidine kinase activity
M1GAS476_RS08420	COG0745	RESPONSE REGULATOR receiver
M1GAS476_RS08425	COG0577	efflux transmembrane transporter activity
M1GAS476_RS08430	COG1136	(ABC) transporter
M1GAS476_RS08480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1GAS476_RS08495	COG1882	Formate acetyltransferase
M1GAS476_RS08500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1GAS476_RS08505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1GAS476_RS08510	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1GAS476_RS08515	COG2390	Transcriptional regulator
M1GAS476_RS08520	COG1349	DNA-binding transcription factor activity
M1GAS476_RS08525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M1GAS476_RS08540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1GAS476_RS08555	COG0564	pseudouridine synthase activity
M1GAS476_RS08585	COG0542	response to heat
M1GAS476_RS08590	COG4463	regulation of RNA biosynthetic process
M1GAS476_RS08605	COG0450	alkyl hydroperoxide reductase
M1GAS476_RS08620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M1GAS476_RS08630	COG3404	Formiminotransferase-cyclodeaminase
M1GAS476_RS08645	COG0531	amino acid
M1GAS476_RS08675	COG3590	peptidase
M1GAS476_RS08680	COG0366	Alpha amylase catalytic
M1GAS476_RS08685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1GAS476_RS08685	COG1263	PTS System
M1GAS476_RS08690	COG2188	Transcriptional regulator
M1GAS476_RS08700	COG2514	catechol 2,3-dioxygenase activity
M1GAS476_RS08710	COG0602	queuosine metabolic process
M1GAS476_RS08725	COG1328	CTP reductase activity
M1GAS476_RS08750	COG1393	Belongs to the ArsC family
M1GAS476_RS08765	COG0519	Catalyzes the synthesis of GMP from XMP
M1GAS476_RS08775	COG2814	Major facilitator Superfamily
M1GAS476_RS08810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1GAS476_RS08815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1GAS476_RS08820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1GAS476_RS08900	COG1511	domain protein
M1GAS476_RS08920	COG5433	transposase activity
M1GAS476_RS08930	COG0305	Participates in initiation and elongation during chromosome replication
M1GAS476_RS08960	COG1760	l-serine dehydratase
M1GAS476_RS08965	COG1760	l-serine dehydratase
M1GAS476_RS08970	COG0741	lytic transglycosylase activity
M1GAS476_RS08975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1GAS476_RS08990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1GAS476_RS09000	COG0612	Peptidase, M16
M1GAS476_RS09010	COG1215	transferase activity, transferring glycosyl groups
M1GAS476_RS09040	COG0516	GMP reductase activity
M1GAS476_RS09040	COG0517	IMP dehydrogenase activity
M1GAS476_RS09050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1GAS476_RS09055	COG0488	(ABC) transporter
M1GAS476_RS09095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1GAS476_RS09100	COG1475	DNA binding