locus-tag	class	description
SPy_0003	COG0592	DNA-directed DNA polymerase activity
SPy_0006	COG0012	GTP binding
SPy_0008	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPy_0009	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPy_0015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPy_0016	COG0531	amino acid
SPy_0019	COG3942	CHAP domain
SPy_0023	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPy_0025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPy_0028	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPy_0033	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPy_0036	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPy_0039	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPy_0044	COG1064	alcohol dehydrogenase
SPy_0045	COG0534	Mate efflux family protein
SPy_0073	COG0201	protein transport
SPy_0093	COG1121	(ABC) transporter
SPy_0094	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPy_0097	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPy_0101	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPy_0102	COG1459	type II secretion system
SPy_0103	COG4537	Required for transformation and DNA binding
SPy_0112	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPy_0115	COG1363	Peptidase, m42
SPy_0121	COG1428	Deoxynucleoside kinase
SPy_0122	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPy_0129	COG4509	Sortase family
SPy_0131	COG4372	Transposase
SPy_0137	COG2031	fatty acid transporter
SPy_0141	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPy_0145	COG0251	oxidation-reduction process
SPy_0148	COG1269	ATP hydrolysis coupled proton transport
SPy_0149	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPy_0151	COG1527	subunit (C
SPy_0163	COG1744	ABC transporter substrate-binding protein PnrA-like
SPy_0172	COG0626	cystathionine gamma-synthase activity
SPy_0178	COG3623	hexulose-6-phosphate isomerase
SPy_0183	COG3448	diguanylate cyclase activity
SPy_0183	COG4175	Glycine betaine
SPy_0185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPy_0185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPy_0189	COG3969	phosphoadenosine phosphosulfate
SPy_0190	COG1475	DNA binding
SPy_0197	COG0157	Belongs to the NadC ModD family
SPy_0198	COG2801	Transposase and inactivated derivatives
SPy_0207	COG1268	BioY protein
SPy_0208	COG1234	tRNA 3'-trailer cleavage
SPy_0223	COG0705	Rhomboid family
SPy_0223	COG0457	Tetratricopeptide repeat
SPy_0229	COG1132	(ABC) transporter
SPy_0230	COG1132	(ABC) transporter
SPy_0235	COG0756	dUTP diphosphatase activity
SPy_0242	COG3290	protein histidine kinase activity
SPy_0248	COG1847	R3H domain protein
SPy_0254	COG1175	transmembrane transport
SPy_0255	COG0395	ABC-type sugar transport system, permease component
SPy_0257	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPy_0260	COG0084	hydrolase, TatD family'
SPy_0265	COG1564	THIamine pyrophosphokinase
SPy_0268	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPy_0277	COG0765	amino acid transport
SPy_0282	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPy_0287	COG0719	Fe-S assembly protein
SPy_0288	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPy_0292	COG1686	Belongs to the peptidase S11 family
SPy_0294	COG0601	transmembrane transport
SPy_0295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPy_0296	COG0444	Belongs to the ABC transporter superfamily
SPy_0303	COG5433	transposase activity
SPy_0305	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPy_0306	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPy_0307	COG1534	Rna-binding protein
SPy_0309	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPy_0310	COG0799	negative regulation of ribosome biogenesis
SPy_0312	COG2226	methyltransferase
SPy_0317	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPy_0319	COG1464	Belongs to the NlpA lipoprotein family
SPy_0323	COG1114	Component of the transport system for branched-chain amino acids
SPy_0326	COG0569	domain protein
SPy_0327	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPy_0330	COG1704	LemA family
SPy_0340	COG1484	DNA-dependent DNA replication
SPy_0342	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPy_0348	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPy_0352	COG1254	Belongs to the acylphosphatase family
SPy_0356	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPy_0369	COG1187	pseudouridine synthase activity
SPy_0373	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPy_0374	COG0671	phosphoesterase, PA-phosphatase related
SPy_0376	COG1242	4 iron, 4 sulfur cluster binding
SPy_0377	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPy_0378	COG1253	flavin adenine dinucleotide binding
SPy_0379	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPy_0383	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPy_0384	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPy_0385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPy_0386	COG1120	ATPase activity
SPy_0390	COG2244	polysaccharide biosynthetic process
SPy_0400	COG0470	DNA polymerase III
SPy_0410	COG1393	Belongs to the ArsC family
SPy_0412	COG0708	Exodeoxyribonuclease III
SPy_0414	COG1304	FMN binding
SPy_0440	COG1028	Short-chain dehydrogenase reductase Sdr
SPy_0441	COG0673	inositol 2-dehydrogenase activity
SPy_0444	COG0494	nUDIX hydrolase
SPy_0447	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPy_0471	COG1702	phosphate starvation-inducible protein PhoH
SPy_0472	COG1573	uracil-dna glycosylase
SPy_0475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPy_0500	COG0433	COG0433 Predicted ATPase
SPy_0501	COG2814	Major facilitator Superfamily
SPy_0503	COG0557	exoribonuclease II activity
SPy_0510	COG0463	Glycosyl transferase, family 2
SPy_0512	COG0778	Nitroreductase
SPy_0513	COG0006	proline dipeptidase activity
SPy_0514	COG1609	Transcriptional regulator
SPy_0516	COG0438	transferase activity, transferring glycosyl groups
SPy_0518	COG4555	ABC transporter
SPy_0524	COG0183	Belongs to the thiolase family
SPy_0528	COG0745	RESPONSE REGULATOR receiver
SPy_0529	COG5002	protein histidine kinase activity
SPy_0530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPy_0532	COG1196	nuclear chromosome segregation
SPy_0534	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPy_0555	COG4695	Portal protein
SPy_0567	COG0561	phosphatase activity
SPy_0568	COG0561	phosphatase activity
SPy_0569	COG0552	protein localization to endoplasmic reticulum
SPy_0570	COG0477	Major facilitator Superfamily
SPy_0571	COG3711	transcriptional antiterminator
SPy_0572	COG1263	PTS System
SPy_0572	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPy_0572	COG2190	(PTS) system
SPy_0575	COG3689	TIGRFAM TIGR03943 family protein
SPy_0576	COG0701	Predicted permease
SPy_0580	COG2183	response to ionizing radiation
SPy_0591	COG0826	peptidase U32
SPy_0593	COG4443	Transcriptional Coactivator p15 (PC4)
SPy_0605	COG0386	Belongs to the glutathione peroxidase family
SPy_0606	COG1164	Oligoendopeptidase f
SPy_0609	COG0772	Belongs to the SEDS family
SPy_0621	COG1078	dGTPase activity
SPy_0627	COG1609	Transcriptional regulator
SPy_0629	COG3716	PTS system mannose fructose sorbose family IID component
SPy_0630	COG3715	PTS system
SPy_0631	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPy_0636	COG1028	Short-chain dehydrogenase reductase Sdr
SPy_0639	COG0800	Aldolase
SPy_0640	COG0546	phosphoglycolate phosphatase activity
SPy_0642	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPy_0644	COG2884	Cell division ATP-binding protein ftsE
SPy_0645	COG2177	Part of the ABC transporter FtsEX involved in
SPy_0649	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPy_0649	COG1199	ATP-dependent helicase activity
SPy_0650	COG0436	Aminotransferase
SPy_0679	COG1475	DNA binding
SPy_0710	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPy_0715	COG2188	Transcriptional regulator
SPy_0716	COG2222	sugar isomerase
SPy_0720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPy_0721	COG0716	FMN binding
SPy_0723	COG0038	chloride channel
SPy_0744	COG1131	(ABC) transporter
SPy_0749	COG4708	membrane
SPy_0752	COG1597	lipid kinase activity
SPy_0772	COG0577	efflux transmembrane transporter activity
SPy_0775	COG2321	neutral zinc metallopeptidase
SPy_0778	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPy_0780	COG1970	mechanosensitive ion channel activity
SPy_0781	COG0358	DNA primase activity
SPy_0782	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPy_0783	COG2151	metal-sulfur cluster biosynthetic enzyme
SPy_0794	COG1216	Glycosyl transferase, family 2
SPy_0807	COG1368	sulfuric ester hydrolase activity
SPy_0808	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPy_0813	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPy_0814	COG0285	dihydrofolate synthase activity
SPy_0816	COG1104	cysteine desulfurase activity
SPy_0822	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPy_0824	COG0583	DNA-binding transcription factor activity
SPy_0827	COG0564	pseudouridine synthase activity
SPy_0836	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPy_0837	COG1136	(ABC) transporter
SPy_0838	COG0577	efflux transmembrane transporter activity
SPy_0839	COG0584	glycerophosphoryl diester phosphodiesterase
SPy_0841	COG1837	Belongs to the UPF0109 family
SPy_0853	COG1349	DNA-binding transcription factor activity
SPy_0854	COG1105	Belongs to the carbohydrate kinase PfkB family
SPy_0855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPy_0855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPy_0855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPy_0856	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPy_0856	COG1388	LysM domain
SPy_0857	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPy_0857	COG1388	LysM domain
SPy_0867	COG0488	(ABC) transporter
SPy_0870	COG0242	peptide deformylase activity
SPy_0872	COG0737	Belongs to the 5'-nucleotidase family
SPy_0873	COG2357	RelA SpoT domain protein
SPy_0874	COG0745	RESPONSE REGULATOR receiver
SPy_0881	COG3425	synthase
SPy_0883	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPy_0898	COG0583	DNA-binding transcription factor activity
SPy_0903	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPy_0904	COG0765	amino acid transport
SPy_0909	COG0187	DNA topoisomerase II activity
SPy_0911	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPy_0913	COG0539	negative regulation of cytoplasmic translation
SPy_0922	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPy_0923	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPy_0925	COG0300	oxidoreductase activity
SPy_0926	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPy_0926	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPy_0929	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPy_0930	COG2384	SAM-dependent methyltransferase
SPy_0932	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPy_0933	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPy_0936	COG1088	dTDP-glucose 4,6-dehydratase activity
SPy_0937	COG0582	viral genome integration into host DNA
SPy_0946	COG3561	AntA/AntB antirepressor
SPy_1010	COG1051	belongs to the nudix hydrolase family
SPy_1011	COG0628	permease
SPy_1012	COG0457	Tetratricopeptide repeat
SPy_1013	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPy_1019	COG1129	ABC transporter
SPy_1025	COG0488	(ABC) transporter
SPy_1026	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPy_1028	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPy_1028	COG0022	dehydrogenase e1 component
SPy_1032	COG5492	domain, Protein
SPy_1033	COG0095	Lipoate-protein ligase
SPy_1034	COG3442	glutamine amidotransferase
SPy_1035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPy_1036	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPy_1040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPy_1043	COG0647	UMP catabolic process
SPy_1047	COG1518	maintenance of DNA repeat elements
SPy_1048	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPy_1059	COG3715	PTS system
SPy_1060	COG3716	PTS system mannose fructose sorbose family IID component
SPy_1061	COG2972	Histidine kinase
SPy_1062	COG2207	Transcriptional regulator
SPy_1062	COG4753	response regulator
SPy_1063	COG1840	ABC-type Fe3 transport system, periplasmic component
SPy_1066	COG1011	Hydrolase
SPy_1067	COG1012	belongs to the aldehyde dehydrogenase family
SPy_1070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPy_1085	COG1131	(ABC) transporter
SPy_1088	COG1396	sequence-specific DNA binding
SPy_1096	COG0285	dihydrofolate synthase activity
SPy_1100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPy_1103	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPy_1104	COG1177	transmembrane transport
SPy_1106	COG4565	transcriptional regulatory protein
SPy_1107	COG3290	protein histidine kinase activity
SPy_1109	COG3493	citrate carrier protein
SPy_1113	COG3700	Belongs to the class B bacterial acid phosphatase family
SPy_1114	COG0038	chloride channel
SPy_1117	COG0628	permease
SPy_1119	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPy_1122	COG1104	cysteine desulfurase activity
SPy_1125	COG2357	RelA SpoT domain protein
SPy_1127	COG0564	pseudouridine synthase activity
SPy_1128	COG0280	phosphate acetyltransferase
SPy_1134	COG1174	glycine betaine transport
SPy_1137	COG2233	PERMEase
SPy_1142	COG2890	protein-(glutamine-N5) methyltransferase activity
SPy_1148	COG1132	(ABC) transporter
SPy_1149	COG1132	(ABC) transporter
SPy_1154	COG3764	Sortase (surface protein transpeptidase)
SPy_1155	COG0346	lactoylglutathione lyase activity
SPy_1159	COG1272	protein, Hemolysin III
SPy_1163	COG0758	DNA mediated transformation
SPy_1164	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPy_1176	COG0511	ligase activity, forming carbon-carbon bonds
SPy_1177	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPy_1180	COG2851	Citrate transporter
SPy_1183	COG0511	ligase activity, forming carbon-carbon bonds
SPy_1184	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPy_1192	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPy_1200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPy_1202	COG2188	Transcriptional regulator
SPy_1206	COG0488	(ABC) transporter
SPy_1209	COG0352	thiamine-phosphate diphosphorylase activity
SPy_1209	COG0351	phosphomethylpyrimidine kinase
SPy_1210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPy_1211	COG1328	CTP reductase activity
SPy_1211	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPy_1212	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPy_1218	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPy_1222	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPy_1223	COG4684	Psort location CytoplasmicMembrane, score
SPy_1224	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPy_1225	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPy_1226	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPy_1227	COG3845	ABC transporter
SPy_1228	COG1744	ABC transporter substrate-binding protein PnrA-like
SPy_1230	COG0295	cytidine deaminase activity
SPy_1232	COG2813	Specifically methylates the guanine in position
SPy_1236	COG5002	protein histidine kinase activity
SPy_1237	COG0745	RESPONSE REGULATOR receiver
SPy_1240	COG0704	Plays a role in the regulation of phosphate uptake
SPy_1243	COG0581	inorganic phosphate transmembrane transporter activity
SPy_1244	COG0573	inorganic phosphate transmembrane transporter activity
SPy_1246	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPy_1246	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPy_1247	COG0483	inositol monophosphate 1-phosphatase activity
SPy_1250	COG0196	riboflavin kinase activity
SPy_1257	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPy_1257	COG1136	(ABC) transporter
SPy_1270	COG1115	amino acid carrier protein
SPy_1272	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPy_1274	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPy_1275	COG1126	abc transporter atp-binding protein
SPy_1276	COG0765	amino acid transport
SPy_1277	COG2824	Alkylphosphonate utilization operon protein PhnA
SPy_1282	COG0469	pyruvate kinase activity
SPy_1285	COG1725	Transcriptional regulator
SPy_1286	COG1131	(ABC) transporter
SPy_1291	COG0058	SHG alpha-glucan phosphorylase activity
SPy_1292	COG1640	4-alpha-glucanotransferase
SPy_1293	COG1609	Transcriptional regulator
SPy_1294	COG2182	Extracellular solute-binding protein
SPy_1295	COG1175	transmembrane transport
SPy_1296	COG3833	ABC-type maltose transport systems, permease component
SPy_1299	COG3833	ABC-type maltose transport systems, permease component
SPy_1301	COG1175	transmembrane transport
SPy_1304	COG0366	Alpha amylase catalytic
SPy_1306	COG2182	Extracellular solute-binding protein
SPy_1308	COG0657	acetylesterase activity
SPy_1309	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPy_1311	COG1696	Membrane protein involved in D-alanine export
SPy_1315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPy_1316	COG1126	abc transporter atp-binding protein
SPy_1323	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPy_1325	COG3711	transcriptional antiterminator
SPy_1325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPy_1328	COG2723	6-phospho-beta-galactosidase activity
SPy_1336	COG2801	Transposase and inactivated derivatives
SPy_1337	COG1187	pseudouridine synthase activity
SPy_1340	COG2814	Major facilitator Superfamily
SPy_1355	COG4109	DRTGG domain
SPy_1356	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPy_1362	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPy_1362	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPy_1364	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPy_1365	COG1956	GAF domain-containing protein
SPy_1369	COG0513	Belongs to the DEAD box helicase family
SPy_1370	COG0726	polysaccharide deacetylase
SPy_1374	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPy_1375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPy_1378	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPy_1386	COG1476	TRANSCRIPTIONal
SPy_1391	COG4122	O-methyltransferase activity
SPy_1392	COG2223	nitrite transmembrane transporter activity
SPy_1398	COG1187	pseudouridine synthase activity
SPy_1408	COG0658	competence protein
SPy_1408	COG2333	competence protein COMEC
SPy_1409	COG1596	polysaccharide export
SPy_1409	COG1555	photosystem II stabilization
SPy_1410	COG0204	Acyl-transferase
SPy_1411	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPy_1415	COG0513	Belongs to the DEAD box helicase family
SPy_1420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPy_1423	COG0768	penicillin binding
SPy_1424	COG2116	formate transmembrane transporter activity
SPy_1427	COG1827	regulation of RNA biosynthetic process
SPy_1434	COG2217	Heavy metal translocating P-type atpase
SPy_1477	COG3723	Recombinational DNA repair protein, rece pathway
SPy_1486	COG1396	sequence-specific DNA binding
SPy_1488	COG0582	viral genome integration into host DNA
SPy_1492	COG2755	lipolytic protein G-D-S-L family
SPy_1495	COG0497	DNA recombination
SPy_1496	COG1438	arginine binding
SPy_1497	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPy_1503	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPy_1505	COG0415	Belongs to the DNA photolyase family
SPy_1507	COG0765	amino acid transport
SPy_1508	COG4703	Protein of unknown function (DUF1797)
SPy_1509	COG0542	response to heat
SPy_1510	COG0494	nUDIX hydrolase
SPy_1514	COG3599	regulation of cell shape
SPy_1515	COG2302	S4 RNA-binding domain
SPy_1519	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPy_1527	COG1217	gtp-binding protein TYPA
SPy_1528	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPy_1529	COG1940	carbohydrate kinase activity
SPy_1531	COG0783	Belongs to the Dps family
SPy_1534	COG4470	Protein conserved in bacteria
SPy_1535	COG1609	Transcriptional regulator
SPy_1536	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPy_1538	COG0742	ribosomal rna small subunit methyltransferase
SPy_1541	COG0549	Belongs to the carbamate kinase family
SPy_1542	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPy_1543	COG1288	antiporter activity
SPy_1547	COG2235	arginine
SPy_1553	COG2972	Histidine kinase
SPy_1558	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPy_1559	COG0785	Cytochrome C biogenesis protein
SPy_1561	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPy_1562	COG1518	maintenance of DNA repeat elements
SPy_1574	COG5433	transposase activity
SPy_1576	COG1605	Chorismate mutase
SPy_1576	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPy_1582	COG2226	methyltransferase
SPy_1586	COG3250	beta-galactosidase activity
SPy_1587	COG4753	response regulator
SPy_1587	COG2207	Transcriptional regulator
SPy_1588	COG2972	Histidine kinase
SPy_1592	COG1653	transport
SPy_1593	COG0395	ABC-type sugar transport system, permease component
SPy_1595	COG1175	transmembrane transport
SPy_1596	COG1940	carbohydrate kinase activity
SPy_1599	COG2723	6-phospho-beta-galactosidase activity
SPy_1600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPy_1604	COG0383	alpha-mannosidase activity
SPy_1616	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPy_1617	COG1739	Uncharacterized protein family UPF0029
SPy_1619	COG1098	S1 RNA binding domain
SPy_1621	COG2197	response regulator
SPy_1622	COG4585	Histidine kinase
SPy_1625	COG2815	serine threonine protein kinase
SPy_1625	COG0515	serine threonine protein kinase
SPy_1627	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPy_1627	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPy_1629	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPy_1634	COG0583	DNA-binding transcription factor activity
SPy_1637	COG0183	Belongs to the thiolase family
SPy_1638	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPy_1640	COG1028	Short-chain dehydrogenase reductase Sdr
SPy_1641	COG2610	gluconate transmembrane transporter activity
SPy_1644	COG0116	Belongs to the methyltransferase superfamily
SPy_1649	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPy_1651	COG3579	cysteine-type endopeptidase activity
SPy_1653	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPy_1654	COG1113	amino acid transport
SPy_1657	COG1126	abc transporter atp-binding protein
SPy_1659	COG0513	Belongs to the DEAD box helicase family
SPy_1664	COG0768	penicillin binding
SPy_1674	COG1131	(ABC) transporter
SPy_1681	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPy_1682	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPy_1691	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPy_1693	COG0656	L-ascorbic acid biosynthetic process
SPy_1695	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPy_1700	COG0561	phosphatase activity
SPy_1701	COG2860	membrane
SPy_1715	COG2217	Heavy metal translocating P-type atpase
SPy_1723	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPy_1724	COG0195	Participates in both transcription termination and antitermination
SPy_1728	COG4473	ABC transporter
SPy_1729	COG1131	(ABC) transporter
SPy_1730	COG0537	adenosine 5'-monophosphoramidase activity
SPy_1733	COG1316	TRANSCRIPTIONal
SPy_1735	COG0802	atpase or kinase
SPy_1736	COG2252	PERMEase
SPy_1737	COG0561	phosphatase activity
SPy_1739	COG3715	PTS system
SPy_1740	COG3716	PTS system mannose fructose sorbose family IID component
SPy_1745	COG0439	Biotin carboxylase
SPy_1748	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPy_1749	COG1028	Short-chain dehydrogenase reductase Sdr
SPy_1750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPy_1758	COG1024	Enoyl-CoA hydratase
SPy_1766	COG0588	phosphoglycerate mutase activity
SPy_1768	COG2261	transglycosylase associated protein
SPy_1776	COG1335	isochorismatase
SPy_1779	COG0436	Aminotransferase
SPy_1781	COG0561	phosphatase activity
SPy_1782	COG0252	asparaginase activity
SPy_1785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPy_1787	COG1129	ABC transporter
SPy_1790	COG1132	(ABC) transporter
SPy_1791	COG4988	ABC transporter
SPy_1793	COG1120	ATPase activity
SPy_1801	COG3942	CHAP domain
SPy_1801	COG1388	LysM domain
SPy_1807	COG5433	transposase activity
SPy_1810	COG1482	cell wall glycoprotein biosynthetic process
SPy_1811	COG1940	carbohydrate kinase activity
SPy_1815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPy_1815	COG2190	(PTS) system
SPy_1815	COG1263	PTS System
SPy_1816	COG1621	beta-fructofuranosidase activity
SPy_1817	COG1609	Transcriptional regulator
SPy_1823	COG2131	deaminase
SPy_1824	COG0006	proline dipeptidase activity
SPy_1833	COG1194	a g-specific adenine glycosylase
SPy_1835	COG3118	belongs to the thioredoxin family
SPy_1842	COG0681	Belongs to the peptidase S26 family
SPy_1844	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPy_1849	COG1882	Formate acetyltransferase
SPy_1850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPy_1854	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPy_1856	COG2814	Major facilitator Superfamily
SPy_1857	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPy_1863	COG0789	Transcriptional regulator
SPy_1866	COG2081	HI0933 family
SPy_1868	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPy_1869	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPy_1873	COG0456	acetyltransferase
SPy_1874	COG1214	PFAM Peptidase M22, glycoprotease
SPy_1877	COG0174	glutamine synthetase
SPy_1878	COG0789	Transcriptional regulator
SPy_1882	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPy_1897	COG0668	transmembrane transport
SPy_1899	COG4720	Psort location CytoplasmicMembrane, score
SPy_1900	COG0351	phosphomethylpyrimidine kinase
SPy_1903	COG1929	Belongs to the glycerate kinase type-1 family
SPy_1904	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPy_1911	COG0577	efflux transmembrane transporter activity
SPy_1912	COG1136	(ABC) transporter
SPy_1917	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPy_1917	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPy_1918	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPy_1932	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPy_1934	COG1476	TRANSCRIPTIONal
SPy_1938	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPy_1940	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPy_1944	COG1045	serine acetyltransferase
SPy_1947	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPy_1949	COG3037	sugar-specific permease SgaT UlaA
SPy_1952	COG3711	transcriptional antiterminator
SPy_1960	COG1846	Transcriptional regulator
SPy_1964	COG4589	Belongs to the CDS family
SPy_1968	COG1862	Preprotein translocase
SPy_1972	COG1523	belongs to the glycosyl hydrolase 13 family
SPy_1976	COG3842	ATPase activity
SPy_1986	COG1263	PTS System
SPy_1986	COG2190	(PTS) system
SPy_1986	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPy_1987	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPy_1990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPy_1991	COG0512	Glutamine amidotransferase of anthranilate synthase
SPy_1992	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPy_2001	COG0601	transmembrane transport
SPy_2003	COG1122	ATPase activity
SPy_2007	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPy_2019	COG3711	transcriptional antiterminator
SPy_2025	COG3942	CHAP domain
SPy_2025	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPy_2026	COG2205	protein histidine kinase activity
SPy_2027	COG0745	RESPONSE REGULATOR receiver
SPy_2029	COG0577	efflux transmembrane transporter activity
SPy_2031	COG1136	(ABC) transporter
SPy_2045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPy_2049	COG1882	Formate acetyltransferase
SPy_2050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPy_2051	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPy_2052	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPy_2053	COG2390	Transcriptional regulator
SPy_2054	COG1349	DNA-binding transcription factor activity
SPy_2055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPy_2059	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPy_2063	COG0564	pseudouridine synthase activity
SPy_2073	COG0542	response to heat
SPy_2074	COG4463	regulation of RNA biosynthetic process
SPy_2079	COG0450	alkyl hydroperoxide reductase
SPy_2082	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPy_2084	COG3404	Formiminotransferase-cyclodeaminase
SPy_2088	COG0531	amino acid
SPy_2095	COG3590	peptidase
SPy_2096	COG0366	Alpha amylase catalytic
SPy_2097	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPy_2097	COG1263	PTS System
SPy_2099	COG2188	Transcriptional regulator
SPy_2103	COG2514	catechol 2,3-dioxygenase activity
SPy_2105	COG0602	queuosine metabolic process
SPy_2110	COG1328	CTP reductase activity
SPy_2115	COG1393	Belongs to the ArsC family
SPy_2118	COG0519	Catalyzes the synthesis of GMP from XMP
SPy_2120	COG2814	Major facilitator Superfamily
SPy_2153	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPy_2154	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPy_2155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPy_2176	COG1511	domain protein
SPy_2180	COG5433	transposase activity
SPy_2182	COG0305	Participates in initiation and elongation during chromosome replication
SPy_2189	COG1760	l-serine dehydratase
SPy_2190	COG1760	l-serine dehydratase
SPy_2191	COG0741	lytic transglycosylase activity
SPy_2193	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPy_2196	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPy_2198	COG0612	Peptidase, M16
SPy_2200	COG1215	transferase activity, transferring glycosyl groups
SPy_2206	COG0516	GMP reductase activity
SPy_2206	COG0517	IMP dehydrogenase activity
SPy_2209	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPy_2210	COG0488	(ABC) transporter
SPy_2216	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPy_2217	COG1475	DNA binding