locus-tag	class	description
VB13_RS00010	COG0592	DNA-directed DNA polymerase activity
VB13_RS00020	COG0012	GTP binding
VB13_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VB13_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VB13_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VB13_RS00240	COG3942	CHAP domain
VB13_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VB13_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VB13_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VB13_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VB13_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VB13_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VB13_RS00355	COG1454	alcohol dehydrogenase
VB13_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
VB13_RS00360	COG1064	alcohol dehydrogenase
VB13_RS00365	COG0534	Mate efflux family protein
VB13_RS00475	COG0201	protein transport
VB13_RS00615	COG1121	(ABC) transporter
VB13_RS00620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VB13_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VB13_RS00635	COG4499	WXG100 protein secretion system (Wss), protein YukC
VB13_RS00655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VB13_RS00660	COG1459	type II secretion system
VB13_RS00665	COG4537	Required for transformation and DNA binding
VB13_RS00710	COG1363	Peptidase, m42
VB13_RS00715	COG5433	transposase activity
VB13_RS00725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VB13_RS00730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VB13_RS00740	COG1428	Deoxynucleoside kinase
VB13_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VB13_RS00775	COG4509	Sortase family
VB13_RS00800	COG2031	fatty acid transporter
VB13_RS00815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
VB13_RS00830	COG0251	oxidation-reduction process
VB13_RS00845	COG1269	ATP hydrolysis coupled proton transport
VB13_RS00850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VB13_RS00860	COG1527	subunit (C
VB13_RS00865	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
VB13_RS00900	COG1744	ABC transporter substrate-binding protein PnrA-like
VB13_RS00945	COG0626	cystathionine gamma-synthase activity
VB13_RS00975	COG3623	hexulose-6-phosphate isomerase
VB13_RS00995	COG3448	diguanylate cyclase activity
VB13_RS00995	COG4175	Glycine betaine
VB13_RS01005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VB13_RS01005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VB13_RS01025	COG3969	phosphoadenosine phosphosulfate
VB13_RS01030	COG1475	DNA binding
VB13_RS01050	COG0157	Belongs to the NadC ModD family
VB13_RS01075	COG1268	BioY protein
VB13_RS01080	COG1234	tRNA 3'-trailer cleavage
VB13_RS01115	COG0705	Rhomboid family
VB13_RS01115	COG0457	Tetratricopeptide repeat
VB13_RS01135	COG1132	(ABC) transporter
VB13_RS01140	COG1132	(ABC) transporter
VB13_RS01150	COG0756	dUTP diphosphatase activity
VB13_RS01175	COG3290	protein histidine kinase activity
VB13_RS01200	COG1847	R3H domain protein
VB13_RS01220	COG1175	transmembrane transport
VB13_RS01225	COG0395	ABC-type sugar transport system, permease component
VB13_RS01235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VB13_RS01250	COG0084	hydrolase, TatD family'
VB13_RS01275	COG1564	THIamine pyrophosphokinase
VB13_RS01290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VB13_RS01330	COG0765	amino acid transport
VB13_RS01350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VB13_RS01360	COG0719	Fe-S assembly protein
VB13_RS01365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VB13_RS01380	COG1686	Belongs to the peptidase S11 family
VB13_RS01385	COG1686	Belongs to the peptidase S11 family
VB13_RS01390	COG4166	transmembrane transport
VB13_RS01395	COG0601	transmembrane transport
VB13_RS01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VB13_RS01405	COG0444	Belongs to the ABC transporter superfamily
VB13_RS01455	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
VB13_RS01460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VB13_RS01465	COG1534	Rna-binding protein
VB13_RS01475	COG1713	HD superfamily hydrolase involved in NAD metabolism
VB13_RS01480	COG0799	negative regulation of ribosome biogenesis
VB13_RS01485	COG2226	methyltransferase
VB13_RS01500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VB13_RS01505	COG1464	Belongs to the NlpA lipoprotein family
VB13_RS01520	COG1114	Component of the transport system for branched-chain amino acids
VB13_RS01530	COG0569	domain protein
VB13_RS01535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VB13_RS01545	COG1704	LemA family
VB13_RS01560	COG0745	RESPONSE REGULATOR receiver
VB13_RS01580	COG1484	DNA-dependent DNA replication
VB13_RS01590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VB13_RS01610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VB13_RS01625	COG1254	Belongs to the acylphosphatase family
VB13_RS01630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VB13_RS01685	COG1187	pseudouridine synthase activity
VB13_RS01700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
VB13_RS01705	COG0671	phosphoesterase, PA-phosphatase related
VB13_RS01710	COG1242	4 iron, 4 sulfur cluster binding
VB13_RS01715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
VB13_RS01720	COG1253	flavin adenine dinucleotide binding
VB13_RS01725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VB13_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VB13_RS01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VB13_RS01750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VB13_RS01755	COG1120	ATPase activity
VB13_RS01765	COG2244	polysaccharide biosynthetic process
VB13_RS01790	COG0470	DNA polymerase III
VB13_RS01820	COG1393	Belongs to the ArsC family
VB13_RS01825	COG0708	Exodeoxyribonuclease III
VB13_RS01830	COG1304	FMN binding
VB13_RS02015	COG0582	viral genome integration into host DNA
VB13_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
VB13_RS02030	COG0673	inositol 2-dehydrogenase activity
VB13_RS02045	COG0494	nUDIX hydrolase
VB13_RS02055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VB13_RS02120	COG2996	Protein conserved in bacteria
VB13_RS02145	COG1702	phosphate starvation-inducible protein PhoH
VB13_RS02150	COG1573	uracil-dna glycosylase
VB13_RS02160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VB13_RS02250	COG0433	COG0433 Predicted ATPase
VB13_RS02255	COG2814	Major facilitator Superfamily
VB13_RS02270	COG0557	exoribonuclease II activity
VB13_RS02300	COG0463	Glycosyl transferase, family 2
VB13_RS02310	COG0778	Nitroreductase
VB13_RS02315	COG0006	proline dipeptidase activity
VB13_RS02320	COG1609	Transcriptional regulator
VB13_RS02330	COG0438	transferase activity, transferring glycosyl groups
VB13_RS02340	COG4555	ABC transporter
VB13_RS02360	COG0183	Belongs to the thiolase family
VB13_RS02375	COG0745	RESPONSE REGULATOR receiver
VB13_RS02380	COG5002	protein histidine kinase activity
VB13_RS02385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VB13_RS02395	COG1196	nuclear chromosome segregation
VB13_RS02410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VB13_RS02515	COG0017	Asparaginyl-tRNA synthetase
VB13_RS02530	COG0124	histidyl-tRNA synthetase
VB13_RS02540	COG0561	phosphatase activity
VB13_RS02545	COG0561	phosphatase activity
VB13_RS02550	COG0552	protein localization to endoplasmic reticulum
VB13_RS02555	COG0477	Major facilitator Superfamily
VB13_RS02560	COG3711	transcriptional antiterminator
VB13_RS02565	COG2190	(PTS) system
VB13_RS02565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VB13_RS02565	COG1263	PTS System
VB13_RS02575	COG3689	TIGRFAM TIGR03943 family protein
VB13_RS02580	COG0701	Predicted permease
VB13_RS02590	COG2183	response to ionizing radiation
VB13_RS02635	COG0826	peptidase U32
VB13_RS02640	COG4443	Transcriptional Coactivator p15 (PC4)
VB13_RS02690	COG0386	Belongs to the glutathione peroxidase family
VB13_RS02695	COG1164	Oligoendopeptidase f
VB13_RS02705	COG0772	Belongs to the SEDS family
VB13_RS02735	COG1078	dGTPase activity
VB13_RS02750	COG1609	Transcriptional regulator
VB13_RS02760	COG3716	PTS system mannose fructose sorbose family IID component
VB13_RS02765	COG3715	PTS system
VB13_RS02770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VB13_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
VB13_RS02805	COG0546	phosphoglycolate phosphatase activity
VB13_RS02820	COG2884	Cell division ATP-binding protein ftsE
VB13_RS02825	COG2177	Part of the ABC transporter FtsEX involved in
VB13_RS02840	COG1199	ATP-dependent helicase activity
VB13_RS02840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VB13_RS02845	COG0436	Aminotransferase
VB13_RS02880	COG2188	Transcriptional regulator
VB13_RS02885	COG2222	sugar isomerase
VB13_RS02895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VB13_RS02900	COG0716	FMN binding
VB13_RS02910	COG0038	chloride channel
VB13_RS02995	COG1131	(ABC) transporter
VB13_RS03015	COG4708	membrane
VB13_RS03025	COG1597	lipid kinase activity
VB13_RS03110	COG0577	efflux transmembrane transporter activity
VB13_RS03120	COG2321	neutral zinc metallopeptidase
VB13_RS03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VB13_RS03145	COG1970	mechanosensitive ion channel activity
VB13_RS03150	COG0358	DNA primase activity
VB13_RS03155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VB13_RS03160	COG2151	metal-sulfur cluster biosynthetic enzyme
VB13_RS03205	COG1216	Glycosyl transferase, family 2
VB13_RS03265	COG1368	sulfuric ester hydrolase activity
VB13_RS03270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VB13_RS03290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VB13_RS03295	COG0285	dihydrofolate synthase activity
VB13_RS03305	COG1104	cysteine desulfurase activity
VB13_RS03330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VB13_RS03335	COG0583	DNA-binding transcription factor activity
VB13_RS03345	COG0564	pseudouridine synthase activity
VB13_RS03375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VB13_RS03380	COG1136	(ABC) transporter
VB13_RS03385	COG0577	efflux transmembrane transporter activity
VB13_RS03390	COG0584	glycerophosphoryl diester phosphodiesterase
VB13_RS03400	COG1837	Belongs to the UPF0109 family
VB13_RS03450	COG1349	DNA-binding transcription factor activity
VB13_RS03455	COG1105	Belongs to the carbohydrate kinase PfkB family
VB13_RS03460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VB13_RS03460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VB13_RS03460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VB13_RS03465	COG1388	LysM domain
VB13_RS03465	COG1705	Flagellar rod assembly protein muramidase FlgJ
VB13_RS03470	COG1388	LysM domain
VB13_RS03470	COG1705	Flagellar rod assembly protein muramidase FlgJ
VB13_RS03490	COG0105	UTP biosynthetic process
VB13_RS03510	COG0488	(ABC) transporter
VB13_RS03515	COG0242	peptide deformylase activity
VB13_RS03520	COG0737	Belongs to the 5'-nucleotidase family
VB13_RS03525	COG2357	RelA SpoT domain protein
VB13_RS03530	COG0745	RESPONSE REGULATOR receiver
VB13_RS03565	COG3425	synthase
VB13_RS03575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VB13_RS03635	COG0583	DNA-binding transcription factor activity
VB13_RS03660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VB13_RS03665	COG0765	amino acid transport
VB13_RS03685	COG0187	DNA topoisomerase II activity
VB13_RS03695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VB13_RS03715	COG0539	negative regulation of cytoplasmic translation
VB13_RS03755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VB13_RS03760	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
VB13_RS03770	COG0300	oxidoreductase activity
VB13_RS03775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
VB13_RS03775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VB13_RS03790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VB13_RS03795	COG2384	SAM-dependent methyltransferase
VB13_RS03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VB13_RS03810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VB13_RS03820	COG1088	dTDP-glucose 4,6-dehydratase activity
VB13_RS03825	COG1051	belongs to the nudix hydrolase family
VB13_RS03830	COG0628	permease
VB13_RS03835	COG0457	Tetratricopeptide repeat
VB13_RS03840	COG1293	RNA-binding protein homologous to eukaryotic snRNP
VB13_RS03855	COG1129	ABC transporter
VB13_RS03875	COG0488	(ABC) transporter
VB13_RS03880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VB13_RS03885	COG0508	dehydrogenase complex catalyzes the overall conversion of
VB13_RS03885	COG0022	dehydrogenase e1 component
VB13_RS03890	COG0508	dehydrogenase complex catalyzes the overall conversion of
VB13_RS03900	COG5492	domain, Protein
VB13_RS03905	COG0095	Lipoate-protein ligase
VB13_RS03910	COG3442	glutamine amidotransferase
VB13_RS03915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VB13_RS03920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
VB13_RS03940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VB13_RS03950	COG0647	UMP catabolic process
VB13_RS03965	COG1518	maintenance of DNA repeat elements
VB13_RS03970	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
VB13_RS04015	COG3715	PTS system
VB13_RS04020	COG3716	PTS system mannose fructose sorbose family IID component
VB13_RS04025	COG2972	Histidine kinase
VB13_RS04030	COG4753	response regulator
VB13_RS04030	COG2207	Transcriptional regulator
VB13_RS04040	COG1012	belongs to the aldehyde dehydrogenase family
VB13_RS04055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VB13_RS04085	COG0285	dihydrofolate synthase activity
VB13_RS04120	COG1176	ABC-type spermidine putrescine transport system, permease component I
VB13_RS04125	COG1177	transmembrane transport
VB13_RS04135	COG4565	transcriptional regulatory protein
VB13_RS04140	COG3290	protein histidine kinase activity
VB13_RS04145	COG3493	citrate carrier protein
VB13_RS04160	COG3700	Belongs to the class B bacterial acid phosphatase family
VB13_RS04165	COG0038	chloride channel
VB13_RS04175	COG0628	permease
VB13_RS04185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VB13_RS04200	COG1104	cysteine desulfurase activity
VB13_RS04215	COG2357	RelA SpoT domain protein
VB13_RS04225	COG0564	pseudouridine synthase activity
VB13_RS04230	COG0280	phosphate acetyltransferase
VB13_RS04250	COG1174	glycine betaine transport
VB13_RS04265	COG2233	PERMEase
VB13_RS04290	COG2890	protein-(glutamine-N5) methyltransferase activity
VB13_RS04320	COG1132	(ABC) transporter
VB13_RS04325	COG1132	(ABC) transporter
VB13_RS04345	COG3764	Sortase (surface protein transpeptidase)
VB13_RS04350	COG0346	lactoylglutathione lyase activity
VB13_RS04365	COG1272	protein, Hemolysin III
VB13_RS04385	COG0758	DNA mediated transformation
VB13_RS04390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VB13_RS04435	COG0511	ligase activity, forming carbon-carbon bonds
VB13_RS04440	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VB13_RS04465	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VB13_RS04485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VB13_RS04495	COG2188	Transcriptional regulator
VB13_RS04515	COG0488	(ABC) transporter
VB13_RS04525	COG0351	phosphomethylpyrimidine kinase
VB13_RS04525	COG0352	thiamine-phosphate diphosphorylase activity
VB13_RS04530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VB13_RS04535	COG1328	CTP reductase activity
VB13_RS04535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VB13_RS04540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VB13_RS04570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VB13_RS04580	COG0095	Lipoate-protein ligase
VB13_RS04590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VB13_RS04595	COG4684	Psort location CytoplasmicMembrane, score
VB13_RS04600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VB13_RS04605	COG1079	Belongs to the binding-protein-dependent transport system permease family
VB13_RS04610	COG4603	Belongs to the binding-protein-dependent transport system permease family
VB13_RS04615	COG3845	ABC transporter
VB13_RS04620	COG1744	ABC transporter substrate-binding protein PnrA-like
VB13_RS04625	COG0295	cytidine deaminase activity
VB13_RS04630	COG2813	Specifically methylates the guanine in position
VB13_RS04645	COG5002	protein histidine kinase activity
VB13_RS04650	COG0745	RESPONSE REGULATOR receiver
VB13_RS04660	COG0704	Plays a role in the regulation of phosphate uptake
VB13_RS04675	COG0581	inorganic phosphate transmembrane transporter activity
VB13_RS04680	COG0573	inorganic phosphate transmembrane transporter activity
VB13_RS04690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VB13_RS04690	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VB13_RS04695	COG0483	inositol monophosphate 1-phosphatase activity
VB13_RS04710	COG0196	riboflavin kinase activity
VB13_RS04740	COG4591	ABC-type transport system involved in lipoprotein release permease component
VB13_RS04740	COG1136	(ABC) transporter
VB13_RS04790	COG1115	amino acid carrier protein
VB13_RS04795	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VB13_RS04805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VB13_RS04810	COG1126	abc transporter atp-binding protein
VB13_RS04815	COG0765	amino acid transport
VB13_RS04820	COG2824	Alkylphosphonate utilization operon protein PhnA
VB13_RS04835	COG0469	pyruvate kinase activity
VB13_RS04850	COG1725	Transcriptional regulator
VB13_RS04855	COG1131	(ABC) transporter
VB13_RS04880	COG0058	SHG alpha-glucan phosphorylase activity
VB13_RS04885	COG1640	4-alpha-glucanotransferase
VB13_RS04890	COG1609	Transcriptional regulator
VB13_RS04895	COG2182	Extracellular solute-binding protein
VB13_RS04900	COG1175	transmembrane transport
VB13_RS04905	COG3833	ABC-type maltose transport systems, permease component
VB13_RS04915	COG0657	acetylesterase activity
VB13_RS04920	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
VB13_RS04930	COG1696	Membrane protein involved in D-alanine export
VB13_RS04950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VB13_RS04955	COG1126	abc transporter atp-binding protein
VB13_RS04965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VB13_RS04975	COG1447	Phosphotransferase system cellobiose-specific component IIA
VB13_RS04985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VB13_RS04985	COG3711	transcriptional antiterminator
VB13_RS04995	COG2723	6-phospho-beta-galactosidase activity
VB13_RS05025	COG0157	Belongs to the NadC ModD family
VB13_RS05055	COG1187	pseudouridine synthase activity
VB13_RS05065	COG2814	Major facilitator Superfamily
VB13_RS05115	COG4109	DRTGG domain
VB13_RS05120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VB13_RS05145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VB13_RS05145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VB13_RS05155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VB13_RS05160	COG1956	GAF domain-containing protein
VB13_RS05180	COG0513	Belongs to the DEAD box helicase family
VB13_RS05185	COG0726	polysaccharide deacetylase
VB13_RS05205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VB13_RS05210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VB13_RS05240	COG1476	TRANSCRIPTIONal
VB13_RS05255	COG4122	O-methyltransferase activity
VB13_RS05260	COG2223	nitrite transmembrane transporter activity
VB13_RS05275	COG1187	pseudouridine synthase activity
VB13_RS05320	COG0658	competence protein
VB13_RS05320	COG2333	competence protein COMEC
VB13_RS05325	COG1555	photosystem II stabilization
VB13_RS05325	COG1596	polysaccharide export
VB13_RS05330	COG0204	Acyl-transferase
VB13_RS05335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VB13_RS05350	COG0513	Belongs to the DEAD box helicase family
VB13_RS05365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VB13_RS05380	COG2116	formate transmembrane transporter activity
VB13_RS05385	COG5433	transposase activity
VB13_RS05395	COG1827	regulation of RNA biosynthetic process
VB13_RS05410	COG2217	Heavy metal translocating P-type atpase
VB13_RS05425	COG2755	lipolytic protein G-D-S-L family
VB13_RS05440	COG0497	DNA recombination
VB13_RS05445	COG1438	arginine binding
VB13_RS05450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
VB13_RS05475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VB13_RS05480	COG0415	Belongs to the DNA photolyase family
VB13_RS05490	COG0765	amino acid transport
VB13_RS05495	COG4703	Protein of unknown function (DUF1797)
VB13_RS05500	COG0542	response to heat
VB13_RS05505	COG0494	nUDIX hydrolase
VB13_RS05520	COG3599	regulation of cell shape
VB13_RS05525	COG2302	S4 RNA-binding domain
VB13_RS05540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VB13_RS05575	COG1217	gtp-binding protein TYPA
VB13_RS05580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VB13_RS05585	COG1940	carbohydrate kinase activity
VB13_RS05595	COG0783	Belongs to the Dps family
VB13_RS05610	COG4470	Protein conserved in bacteria
VB13_RS05615	COG1609	Transcriptional regulator
VB13_RS05620	COG3480	Lon protease (S16) C-terminal proteolytic domain
VB13_RS05630	COG0742	ribosomal rna small subunit methyltransferase
VB13_RS05640	COG0549	Belongs to the carbamate kinase family
VB13_RS05645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VB13_RS05650	COG1288	antiporter activity
VB13_RS05660	COG0454	-acetyltransferase
VB13_RS05665	COG2235	arginine
VB13_RS05690	COG2972	Histidine kinase
VB13_RS05705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VB13_RS05710	COG0785	Cytochrome C biogenesis protein
VB13_RS05715	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
VB13_RS05720	COG1518	maintenance of DNA repeat elements
VB13_RS05780	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VB13_RS05780	COG1605	Chorismate mutase
VB13_RS05800	COG2226	methyltransferase
VB13_RS05810	COG3250	beta-galactosidase activity
VB13_RS05815	COG4753	response regulator
VB13_RS05815	COG2207	Transcriptional regulator
VB13_RS05820	COG2972	Histidine kinase
VB13_RS05830	COG1653	transport
VB13_RS05835	COG0395	ABC-type sugar transport system, permease component
VB13_RS05840	COG1175	transmembrane transport
VB13_RS05850	COG2723	6-phospho-beta-galactosidase activity
VB13_RS05855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VB13_RS05870	COG0383	alpha-mannosidase activity
VB13_RS06020	COG1783	phage Terminase large subunit
VB13_RS06215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
VB13_RS06220	COG1739	Uncharacterized protein family UPF0029
VB13_RS06230	COG1098	S1 RNA binding domain
VB13_RS06240	COG2197	response regulator
VB13_RS06245	COG4585	Histidine kinase
VB13_RS06255	COG2815	serine threonine protein kinase
VB13_RS06255	COG0515	serine threonine protein kinase
VB13_RS06265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VB13_RS06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VB13_RS06275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VB13_RS06295	COG0583	DNA-binding transcription factor activity
VB13_RS06300	COG0183	Belongs to the thiolase family
VB13_RS06305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
VB13_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
VB13_RS06320	COG2610	gluconate transmembrane transporter activity
VB13_RS06335	COG0116	Belongs to the methyltransferase superfamily
VB13_RS06360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VB13_RS06365	COG3579	cysteine-type endopeptidase activity
VB13_RS06375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VB13_RS06380	COG1113	amino acid transport
VB13_RS06385	COG0492	ferredoxin-NADP+ reductase activity
VB13_RS06395	COG1126	abc transporter atp-binding protein
VB13_RS06405	COG0513	Belongs to the DEAD box helicase family
VB13_RS06415	COG0768	penicillin binding
VB13_RS06450	COG1131	(ABC) transporter
VB13_RS06460	COG5433	transposase activity
VB13_RS06480	COG0446	pyridine nucleotide-disulphide oxidoreductase
VB13_RS06485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VB13_RS06520	COG1755	Isoprenylcysteine carboxyl methyltransferase
VB13_RS06525	COG0656	L-ascorbic acid biosynthetic process
VB13_RS06535	COG1283	sodium-dependent phosphate transmembrane transporter activity
VB13_RS06555	COG0561	phosphatase activity
VB13_RS06560	COG2860	membrane
VB13_RS06585	COG3775	system Galactitol-specific IIC component
VB13_RS06610	COG2217	Heavy metal translocating P-type atpase
VB13_RS06640	COG2740	Nucleic-acid-binding protein implicated in transcription termination
VB13_RS06645	COG0195	Participates in both transcription termination and antitermination
VB13_RS06670	COG4473	ABC transporter
VB13_RS06675	COG1131	(ABC) transporter
VB13_RS06680	COG0537	adenosine 5'-monophosphoramidase activity
VB13_RS06690	COG1316	TRANSCRIPTIONal
VB13_RS06700	COG0802	atpase or kinase
VB13_RS06705	COG2252	PERMEase
VB13_RS06710	COG0561	phosphatase activity
VB13_RS06720	COG3715	PTS system
VB13_RS06725	COG3716	PTS system mannose fructose sorbose family IID component
VB13_RS06750	COG0439	Biotin carboxylase
VB13_RS06765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VB13_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
VB13_RS06775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VB13_RS06800	COG1024	Enoyl-CoA hydratase
VB13_RS06835	COG0588	phosphoglycerate mutase activity
VB13_RS06840	COG2261	transglycosylase associated protein
VB13_RS06865	COG0574	Belongs to the PEP-utilizing enzyme family
VB13_RS06865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VB13_RS06870	COG1335	isochorismatase
VB13_RS06880	COG0436	Aminotransferase
VB13_RS06890	COG0561	phosphatase activity
VB13_RS06895	COG0252	asparaginase activity
VB13_RS06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VB13_RS06915	COG1129	ABC transporter
VB13_RS06930	COG1132	(ABC) transporter
VB13_RS06935	COG4988	ABC transporter
VB13_RS06940	COG1120	ATPase activity
VB13_RS06965	COG1388	LysM domain
VB13_RS06965	COG3942	CHAP domain
VB13_RS06985	COG5433	transposase activity
VB13_RS06990	COG1482	cell wall glycoprotein biosynthetic process
VB13_RS06995	COG1940	carbohydrate kinase activity
VB13_RS07005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VB13_RS07005	COG1263	PTS System
VB13_RS07005	COG2190	(PTS) system
VB13_RS07010	COG1621	beta-fructofuranosidase activity
VB13_RS07015	COG1609	Transcriptional regulator
VB13_RS07035	COG2131	deaminase
VB13_RS07040	COG0006	proline dipeptidase activity
VB13_RS07080	COG1194	a g-specific adenine glycosylase
VB13_RS07090	COG3118	belongs to the thioredoxin family
VB13_RS07120	COG0681	Belongs to the peptidase S26 family
VB13_RS07125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VB13_RS07140	COG1882	Formate acetyltransferase
VB13_RS07160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VB13_RS07170	COG2814	Major facilitator Superfamily
VB13_RS07175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VB13_RS07200	COG0789	Transcriptional regulator
VB13_RS07215	COG5433	transposase activity
VB13_RS07220	COG2081	HI0933 family
VB13_RS07230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VB13_RS07235	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VB13_RS07255	COG0456	acetyltransferase
VB13_RS07260	COG1214	PFAM Peptidase M22, glycoprotease
VB13_RS07275	COG0174	glutamine synthetase
VB13_RS07280	COG0789	Transcriptional regulator
VB13_RS07295	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
VB13_RS07350	COG0668	transmembrane transport
VB13_RS07360	COG4720	Psort location CytoplasmicMembrane, score
VB13_RS07365	COG0351	phosphomethylpyrimidine kinase
VB13_RS07410	COG1929	Belongs to the glycerate kinase type-1 family
VB13_RS07415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VB13_RS07440	COG0577	efflux transmembrane transporter activity
VB13_RS07445	COG1136	(ABC) transporter
VB13_RS07470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VB13_RS07470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VB13_RS07475	COG1447	Phosphotransferase system cellobiose-specific component IIA
VB13_RS07530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VB13_RS07535	COG1476	TRANSCRIPTIONal
VB13_RS07555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VB13_RS07565	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
VB13_RS07580	COG1045	serine acetyltransferase
VB13_RS07595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VB13_RS07610	COG3711	transcriptional antiterminator
VB13_RS07635	COG0431	NADPH-dependent FMN reductase
VB13_RS07640	COG1846	Transcriptional regulator
VB13_RS07660	COG4589	Belongs to the CDS family
VB13_RS07670	COG1862	Preprotein translocase
VB13_RS07680	COG1523	belongs to the glycosyl hydrolase 13 family
VB13_RS07690	COG3842	ATPase activity
VB13_RS07730	COG1263	PTS System
VB13_RS07730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VB13_RS07730	COG2190	(PTS) system
VB13_RS07735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VB13_RS07770	COG2801	Transposase and inactivated derivatives
VB13_RS07795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VB13_RS07800	COG0512	Glutamine amidotransferase of anthranilate synthase
VB13_RS07805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VB13_RS07845	COG0601	transmembrane transport
VB13_RS07855	COG1122	ATPase activity
VB13_RS07875	COG0803	Belongs to the bacterial solute-binding protein 9 family
VB13_RS07905	COG3711	transcriptional antiterminator
VB13_RS07915	COG1705	Flagellar rod assembly protein muramidase FlgJ
VB13_RS07915	COG3942	CHAP domain
VB13_RS07920	COG2205	protein histidine kinase activity
VB13_RS07925	COG0745	RESPONSE REGULATOR receiver
VB13_RS07930	COG0577	efflux transmembrane transporter activity
VB13_RS07935	COG1136	(ABC) transporter
VB13_RS08000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VB13_RS08015	COG1882	Formate acetyltransferase
VB13_RS08020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VB13_RS08025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VB13_RS08030	COG1447	Phosphotransferase system cellobiose-specific component IIA
VB13_RS08035	COG2390	Transcriptional regulator
VB13_RS08040	COG1349	DNA-binding transcription factor activity
VB13_RS08045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VB13_RS08060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VB13_RS08070	COG0564	pseudouridine synthase activity
VB13_RS08100	COG0542	response to heat
VB13_RS08105	COG4463	regulation of RNA biosynthetic process
VB13_RS08120	COG5433	transposase activity
VB13_RS08125	COG0450	alkyl hydroperoxide reductase
VB13_RS08140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VB13_RS08150	COG3404	Formiminotransferase-cyclodeaminase
VB13_RS08165	COG0531	amino acid
VB13_RS08195	COG3590	peptidase
VB13_RS08200	COG0366	Alpha amylase catalytic
VB13_RS08205	COG1263	PTS System
VB13_RS08205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VB13_RS08210	COG2188	Transcriptional regulator
VB13_RS08220	COG2514	catechol 2,3-dioxygenase activity
VB13_RS08230	COG0602	queuosine metabolic process
VB13_RS08250	COG1328	CTP reductase activity
VB13_RS08275	COG1393	Belongs to the ArsC family
VB13_RS08290	COG0519	Catalyzes the synthesis of GMP from XMP
VB13_RS08335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VB13_RS08340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VB13_RS08345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VB13_RS08430	COG1511	domain protein
VB13_RS08450	COG0305	Participates in initiation and elongation during chromosome replication
VB13_RS08480	COG1760	l-serine dehydratase
VB13_RS08485	COG1760	l-serine dehydratase
VB13_RS08490	COG0741	lytic transglycosylase activity
VB13_RS08495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VB13_RS08510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VB13_RS08520	COG0612	Peptidase, M16
VB13_RS08540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VB13_RS08560	COG0516	GMP reductase activity
VB13_RS08560	COG0517	IMP dehydrogenase activity
VB13_RS08570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VB13_RS08575	COG0488	(ABC) transporter
VB13_RS08610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VB13_RS08615	COG1475	DNA binding