locus-tag	class	description
MGAS10270_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS10270_RS00020	COG0012	GTP binding
MGAS10270_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS10270_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS10270_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS10270_RS00065	COG0531	amino acid
MGAS10270_RS00240	COG3942	CHAP domain
MGAS10270_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS10270_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS10270_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS10270_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS10270_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS10270_RS00335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS10270_RS00350	COG1454	alcohol dehydrogenase
MGAS10270_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
MGAS10270_RS00355	COG1064	alcohol dehydrogenase
MGAS10270_RS00360	COG0534	Mate efflux family protein
MGAS10270_RS00605	COG1121	(ABC) transporter
MGAS10270_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS10270_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS10270_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS10270_RS00650	COG1459	type II secretion system
MGAS10270_RS00655	COG4537	Required for transformation and DNA binding
MGAS10270_RS00690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS10270_RS00695	COG1363	Peptidase, m42
MGAS10270_RS00705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS10270_RS00710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS10270_RS00720	COG1428	Deoxynucleoside kinase
MGAS10270_RS00725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS10270_RS00785	COG2031	fatty acid transporter
MGAS10270_RS00800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS10270_RS00815	COG0251	oxidation-reduction process
MGAS10270_RS00830	COG1269	ATP hydrolysis coupled proton transport
MGAS10270_RS00835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS10270_RS00845	COG1527	subunit (C
MGAS10270_RS00850	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS10270_RS00885	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS10270_RS00925	COG0626	cystathionine gamma-synthase activity
MGAS10270_RS00955	COG3623	hexulose-6-phosphate isomerase
MGAS10270_RS00975	COG4175	Glycine betaine
MGAS10270_RS00975	COG3448	diguanylate cyclase activity
MGAS10270_RS00985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS10270_RS00985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS10270_RS01005	COG3969	phosphoadenosine phosphosulfate
MGAS10270_RS01010	COG1475	DNA binding
MGAS10270_RS01020	COG2801	Transposase and inactivated derivatives
MGAS10270_RS01025	COG2801	Transposase and inactivated derivatives
MGAS10270_RS01030	COG2801	Transposase and inactivated derivatives
MGAS10270_RS01045	COG0157	Belongs to the NadC ModD family
MGAS10270_RS01050	COG2801	Transposase and inactivated derivatives
MGAS10270_RS01070	COG1268	BioY protein
MGAS10270_RS01075	COG1234	tRNA 3'-trailer cleavage
MGAS10270_RS01125	COG1132	(ABC) transporter
MGAS10270_RS01130	COG1132	(ABC) transporter
MGAS10270_RS01140	COG0756	dUTP diphosphatase activity
MGAS10270_RS01165	COG3290	protein histidine kinase activity
MGAS10270_RS01190	COG1847	R3H domain protein
MGAS10270_RS01210	COG1175	transmembrane transport
MGAS10270_RS01215	COG0395	ABC-type sugar transport system, permease component
MGAS10270_RS01225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS10270_RS01240	COG0084	hydrolase, TatD family'
MGAS10270_RS01265	COG1564	THIamine pyrophosphokinase
MGAS10270_RS01280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS10270_RS01315	COG0765	amino acid transport
MGAS10270_RS01335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS10270_RS01345	COG0719	Fe-S assembly protein
MGAS10270_RS01350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS10270_RS01365	COG1686	Belongs to the peptidase S11 family
MGAS10270_RS01370	COG1686	Belongs to the peptidase S11 family
MGAS10270_RS01375	COG4166	transmembrane transport
MGAS10270_RS01380	COG0601	transmembrane transport
MGAS10270_RS01385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS10270_RS01390	COG0444	Belongs to the ABC transporter superfamily
MGAS10270_RS01435	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS10270_RS01440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS10270_RS01445	COG1534	Rna-binding protein
MGAS10270_RS01455	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS10270_RS01460	COG0799	negative regulation of ribosome biogenesis
MGAS10270_RS01465	COG2226	methyltransferase
MGAS10270_RS01480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10270_RS01485	COG1464	Belongs to the NlpA lipoprotein family
MGAS10270_RS01500	COG1114	Component of the transport system for branched-chain amino acids
MGAS10270_RS01510	COG0569	domain protein
MGAS10270_RS01515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS10270_RS01525	COG1704	LemA family
MGAS10270_RS01540	COG0745	RESPONSE REGULATOR receiver
MGAS10270_RS01560	COG1484	DNA-dependent DNA replication
MGAS10270_RS01570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS10270_RS01590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS10270_RS01605	COG1254	Belongs to the acylphosphatase family
MGAS10270_RS01610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS10270_RS01665	COG1187	pseudouridine synthase activity
MGAS10270_RS01680	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS10270_RS01685	COG0671	phosphoesterase, PA-phosphatase related
MGAS10270_RS01690	COG1242	4 iron, 4 sulfur cluster binding
MGAS10270_RS01695	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS10270_RS01700	COG1253	flavin adenine dinucleotide binding
MGAS10270_RS01705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS10270_RS01720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS10270_RS01725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS10270_RS01730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS10270_RS01735	COG1120	ATPase activity
MGAS10270_RS01745	COG2244	polysaccharide biosynthetic process
MGAS10270_RS01770	COG0470	DNA polymerase III
MGAS10270_RS01800	COG1393	Belongs to the ArsC family
MGAS10270_RS01805	COG0708	Exodeoxyribonuclease III
MGAS10270_RS01815	COG1304	FMN binding
MGAS10270_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10270_RS01920	COG0673	inositol 2-dehydrogenase activity
MGAS10270_RS01935	COG0494	nUDIX hydrolase
MGAS10270_RS01945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS10270_RS02035	COG1702	phosphate starvation-inducible protein PhoH
MGAS10270_RS02040	COG1573	uracil-dna glycosylase
MGAS10270_RS02050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS10270_RS02075	COG3328	transposase activity
MGAS10270_RS02080	COG3328	transposase activity
MGAS10270_RS02135	COG0433	COG0433 Predicted ATPase
MGAS10270_RS02140	COG2814	Major facilitator Superfamily
MGAS10270_RS02150	COG0557	exoribonuclease II activity
MGAS10270_RS02180	COG0463	Glycosyl transferase, family 2
MGAS10270_RS02195	COG0006	proline dipeptidase activity
MGAS10270_RS02200	COG1609	Transcriptional regulator
MGAS10270_RS02210	COG0438	transferase activity, transferring glycosyl groups
MGAS10270_RS02240	COG0183	Belongs to the thiolase family
MGAS10270_RS02255	COG0745	RESPONSE REGULATOR receiver
MGAS10270_RS02260	COG5002	protein histidine kinase activity
MGAS10270_RS02265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS10270_RS02275	COG1196	nuclear chromosome segregation
MGAS10270_RS02285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS10270_RS02395	COG0561	phosphatase activity
MGAS10270_RS02400	COG0561	phosphatase activity
MGAS10270_RS02405	COG0552	protein localization to endoplasmic reticulum
MGAS10270_RS02410	COG0477	Major facilitator Superfamily
MGAS10270_RS02415	COG3711	transcriptional antiterminator
MGAS10270_RS02420	COG1263	PTS System
MGAS10270_RS02420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10270_RS02420	COG2190	(PTS) system
MGAS10270_RS02430	COG3689	TIGRFAM TIGR03943 family protein
MGAS10270_RS02435	COG0701	Predicted permease
MGAS10270_RS02445	COG2183	response to ionizing radiation
MGAS10270_RS02490	COG0826	peptidase U32
MGAS10270_RS02495	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS10270_RS02525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MGAS10270_RS02550	COG0386	Belongs to the glutathione peroxidase family
MGAS10270_RS02555	COG1164	Oligoendopeptidase f
MGAS10270_RS02565	COG0772	Belongs to the SEDS family
MGAS10270_RS02600	COG1078	dGTPase activity
MGAS10270_RS02615	COG1609	Transcriptional regulator
MGAS10270_RS02625	COG3716	PTS system mannose fructose sorbose family IID component
MGAS10270_RS02630	COG3715	PTS system
MGAS10270_RS02635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10270_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10270_RS02665	COG0800	Aldolase
MGAS10270_RS02670	COG0546	phosphoglycolate phosphatase activity
MGAS10270_RS02675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS10270_RS02685	COG2884	Cell division ATP-binding protein ftsE
MGAS10270_RS02690	COG2177	Part of the ABC transporter FtsEX involved in
MGAS10270_RS02705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS10270_RS02705	COG1199	ATP-dependent helicase activity
MGAS10270_RS02710	COG0436	Aminotransferase
MGAS10270_RS02890	COG1598	PFAM Uncharacterised protein family UPF0150
MGAS10270_RS02930	COG0740	serine-type endopeptidase activity
MGAS10270_RS03025	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10270_RS03050	COG2188	Transcriptional regulator
MGAS10270_RS03055	COG2222	sugar isomerase
MGAS10270_RS03065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS10270_RS03070	COG0716	FMN binding
MGAS10270_RS03080	COG0038	chloride channel
MGAS10270_RS03150	COG1131	(ABC) transporter
MGAS10270_RS03170	COG4708	membrane
MGAS10270_RS03180	COG1597	lipid kinase activity
MGAS10270_RS03265	COG0577	efflux transmembrane transporter activity
MGAS10270_RS03275	COG2321	neutral zinc metallopeptidase
MGAS10270_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10270_RS03300	COG1970	mechanosensitive ion channel activity
MGAS10270_RS03305	COG0358	DNA primase activity
MGAS10270_RS03310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS10270_RS03315	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS10270_RS03360	COG1216	Glycosyl transferase, family 2
MGAS10270_RS03420	COG1368	sulfuric ester hydrolase activity
MGAS10270_RS03425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS10270_RS03445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS10270_RS03450	COG0285	dihydrofolate synthase activity
MGAS10270_RS03460	COG1104	cysteine desulfurase activity
MGAS10270_RS03485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS10270_RS03490	COG0583	DNA-binding transcription factor activity
MGAS10270_RS03500	COG0564	pseudouridine synthase activity
MGAS10270_RS03505	COG5433	transposase activity
MGAS10270_RS03535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS10270_RS03540	COG1136	(ABC) transporter
MGAS10270_RS03545	COG0577	efflux transmembrane transporter activity
MGAS10270_RS03550	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS10270_RS03560	COG1837	Belongs to the UPF0109 family
MGAS10270_RS03610	COG1349	DNA-binding transcription factor activity
MGAS10270_RS03615	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS10270_RS03620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS10270_RS03620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS10270_RS03620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS10270_RS03625	COG1388	LysM domain
MGAS10270_RS03625	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10270_RS03630	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10270_RS03630	COG1388	LysM domain
MGAS10270_RS03650	COG0105	UTP biosynthetic process
MGAS10270_RS03670	COG0488	(ABC) transporter
MGAS10270_RS03680	COG0242	peptide deformylase activity
MGAS10270_RS03685	COG0737	Belongs to the 5'-nucleotidase family
MGAS10270_RS03690	COG2357	RelA SpoT domain protein
MGAS10270_RS03695	COG0745	RESPONSE REGULATOR receiver
MGAS10270_RS03730	COG3425	synthase
MGAS10270_RS03740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS10270_RS03785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MGAS10270_RS03800	COG0583	DNA-binding transcription factor activity
MGAS10270_RS03825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10270_RS03830	COG0765	amino acid transport
MGAS10270_RS03850	COG0187	DNA topoisomerase II activity
MGAS10270_RS03865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS10270_RS03885	COG0539	negative regulation of cytoplasmic translation
MGAS10270_RS03920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS10270_RS03925	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS10270_RS03935	COG0300	oxidoreductase activity
MGAS10270_RS03940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS10270_RS03940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS10270_RS03955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS10270_RS03960	COG2384	SAM-dependent methyltransferase
MGAS10270_RS03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS10270_RS03975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS10270_RS03985	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS10270_RS03990	COG0582	viral genome integration into host DNA
MGAS10270_RS04100	COG1783	phage Terminase large subunit
MGAS10270_RS04250	COG1051	belongs to the nudix hydrolase family
MGAS10270_RS04255	COG0628	permease
MGAS10270_RS04260	COG0457	Tetratricopeptide repeat
MGAS10270_RS04265	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS10270_RS04280	COG1129	ABC transporter
MGAS10270_RS04300	COG0488	(ABC) transporter
MGAS10270_RS04305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS10270_RS04310	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS10270_RS04310	COG0022	dehydrogenase e1 component
MGAS10270_RS04315	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS10270_RS04330	COG5492	domain, Protein
MGAS10270_RS04335	COG0095	Lipoate-protein ligase
MGAS10270_RS04340	COG3442	glutamine amidotransferase
MGAS10270_RS04345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS10270_RS04350	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS10270_RS04370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS10270_RS04380	COG0647	UMP catabolic process
MGAS10270_RS04395	COG1518	maintenance of DNA repeat elements
MGAS10270_RS04400	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS10270_RS04450	COG3715	PTS system
MGAS10270_RS04455	COG3716	PTS system mannose fructose sorbose family IID component
MGAS10270_RS04460	COG2972	Histidine kinase
MGAS10270_RS04465	COG4753	response regulator
MGAS10270_RS04465	COG2207	Transcriptional regulator
MGAS10270_RS04475	COG1012	belongs to the aldehyde dehydrogenase family
MGAS10270_RS04490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS10270_RS04570	COG1131	(ABC) transporter
MGAS10270_RS04625	COG0285	dihydrofolate synthase activity
MGAS10270_RS04645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS10270_RS04660	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS10270_RS04665	COG1177	transmembrane transport
MGAS10270_RS04675	COG4565	transcriptional regulatory protein
MGAS10270_RS04680	COG3290	protein histidine kinase activity
MGAS10270_RS04685	COG3493	citrate carrier protein
MGAS10270_RS04700	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS10270_RS04705	COG0038	chloride channel
MGAS10270_RS04715	COG0628	permease
MGAS10270_RS04740	COG1104	cysteine desulfurase activity
MGAS10270_RS04755	COG2357	RelA SpoT domain protein
MGAS10270_RS04765	COG0564	pseudouridine synthase activity
MGAS10270_RS04770	COG0280	phosphate acetyltransferase
MGAS10270_RS04775	COG4221	oxidoreductase activity
MGAS10270_RS04790	COG1174	glycine betaine transport
MGAS10270_RS04805	COG2233	PERMEase
MGAS10270_RS04830	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS10270_RS04860	COG1132	(ABC) transporter
MGAS10270_RS04865	COG1132	(ABC) transporter
MGAS10270_RS04885	COG3764	Sortase (surface protein transpeptidase)
MGAS10270_RS04890	COG0346	lactoylglutathione lyase activity
MGAS10270_RS04905	COG1272	protein, Hemolysin III
MGAS10270_RS04925	COG0758	DNA mediated transformation
MGAS10270_RS04930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS10270_RS04975	COG0511	ligase activity, forming carbon-carbon bonds
MGAS10270_RS04980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS10270_RS04995	COG2851	Citrate transporter
MGAS10270_RS05005	COG0511	ligase activity, forming carbon-carbon bonds
MGAS10270_RS05010	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS10270_RS05045	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS10270_RS05065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS10270_RS05075	COG2188	Transcriptional regulator
MGAS10270_RS05095	COG0488	(ABC) transporter
MGAS10270_RS05105	COG0352	thiamine-phosphate diphosphorylase activity
MGAS10270_RS05105	COG0351	phosphomethylpyrimidine kinase
MGAS10270_RS05110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS10270_RS05115	COG1328	CTP reductase activity
MGAS10270_RS05115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS10270_RS05120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS10270_RS05150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS10270_RS05160	COG0095	Lipoate-protein ligase
MGAS10270_RS05170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS10270_RS05175	COG4684	Psort location CytoplasmicMembrane, score
MGAS10270_RS05180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS10270_RS05185	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS10270_RS05190	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS10270_RS05195	COG3845	ABC transporter
MGAS10270_RS05200	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS10270_RS05205	COG0295	cytidine deaminase activity
MGAS10270_RS05210	COG2813	Specifically methylates the guanine in position
MGAS10270_RS05225	COG5002	protein histidine kinase activity
MGAS10270_RS05230	COG0745	RESPONSE REGULATOR receiver
MGAS10270_RS05240	COG0704	Plays a role in the regulation of phosphate uptake
MGAS10270_RS05255	COG0581	inorganic phosphate transmembrane transporter activity
MGAS10270_RS05260	COG0573	inorganic phosphate transmembrane transporter activity
MGAS10270_RS05270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS10270_RS05270	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS10270_RS05275	COG0483	inositol monophosphate 1-phosphatase activity
MGAS10270_RS05290	COG0196	riboflavin kinase activity
MGAS10270_RS05320	COG1136	(ABC) transporter
MGAS10270_RS05320	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS10270_RS05370	COG1115	amino acid carrier protein
MGAS10270_RS05375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS10270_RS05385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10270_RS05390	COG1126	abc transporter atp-binding protein
MGAS10270_RS05395	COG0765	amino acid transport
MGAS10270_RS05400	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS10270_RS05415	COG0469	pyruvate kinase activity
MGAS10270_RS05430	COG1725	Transcriptional regulator
MGAS10270_RS05435	COG1131	(ABC) transporter
MGAS10270_RS05455	COG0058	SHG alpha-glucan phosphorylase activity
MGAS10270_RS05460	COG1640	4-alpha-glucanotransferase
MGAS10270_RS05465	COG1609	Transcriptional regulator
MGAS10270_RS05470	COG2182	Extracellular solute-binding protein
MGAS10270_RS05475	COG1175	transmembrane transport
MGAS10270_RS05480	COG3833	ABC-type maltose transport systems, permease component
MGAS10270_RS05495	COG3833	ABC-type maltose transport systems, permease component
MGAS10270_RS05500	COG1175	transmembrane transport
MGAS10270_RS05510	COG0366	Alpha amylase catalytic
MGAS10270_RS05515	COG2182	Extracellular solute-binding protein
MGAS10270_RS05525	COG0657	acetylesterase activity
MGAS10270_RS05530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS10270_RS05540	COG1696	Membrane protein involved in D-alanine export
MGAS10270_RS05560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10270_RS05565	COG1126	abc transporter atp-binding protein
MGAS10270_RS05570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10270_RS05580	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS10270_RS05590	COG3711	transcriptional antiterminator
MGAS10270_RS05590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS10270_RS05600	COG2723	6-phospho-beta-galactosidase activity
MGAS10270_RS05625	COG2801	Transposase and inactivated derivatives
MGAS10270_RS05630	COG1187	pseudouridine synthase activity
MGAS10270_RS05640	COG2814	Major facilitator Superfamily
MGAS10270_RS05690	COG4109	DRTGG domain
MGAS10270_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10270_RS05740	COG0800	Aldolase
MGAS10270_RS05745	COG2186	Transcriptional regulator
MGAS10270_RS05750	COG3250	beta-galactosidase activity
MGAS10270_RS05760	COG2211	Major facilitator Superfamily
MGAS10270_RS05780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS10270_RS05780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS10270_RS05785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS10270_RS05790	COG1956	GAF domain-containing protein
MGAS10270_RS05810	COG0513	Belongs to the DEAD box helicase family
MGAS10270_RS05815	COG0726	polysaccharide deacetylase
MGAS10270_RS05835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS10270_RS05840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS10270_RS05860	COG2801	Transposase and inactivated derivatives
MGAS10270_RS05865	COG2801	Transposase and inactivated derivatives
MGAS10270_RS05880	COG1476	TRANSCRIPTIONal
MGAS10270_RS05895	COG4122	O-methyltransferase activity
MGAS10270_RS05900	COG2223	nitrite transmembrane transporter activity
MGAS10270_RS05915	COG1187	pseudouridine synthase activity
MGAS10270_RS05955	COG2333	competence protein COMEC
MGAS10270_RS05955	COG0658	competence protein
MGAS10270_RS05960	COG1555	photosystem II stabilization
MGAS10270_RS05960	COG1596	polysaccharide export
MGAS10270_RS05965	COG0204	Acyl-transferase
MGAS10270_RS05970	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS10270_RS05985	COG0513	Belongs to the DEAD box helicase family
MGAS10270_RS06000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS10270_RS06015	COG0768	penicillin binding
MGAS10270_RS06020	COG2116	formate transmembrane transporter activity
MGAS10270_RS06030	COG1827	regulation of RNA biosynthetic process
MGAS10270_RS06045	COG2217	Heavy metal translocating P-type atpase
MGAS10270_RS06060	COG2755	lipolytic protein G-D-S-L family
MGAS10270_RS06075	COG0497	DNA recombination
MGAS10270_RS06080	COG1438	arginine binding
MGAS10270_RS06085	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS10270_RS06110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS10270_RS06115	COG0415	Belongs to the DNA photolyase family
MGAS10270_RS06125	COG0765	amino acid transport
MGAS10270_RS06130	COG4703	Protein of unknown function (DUF1797)
MGAS10270_RS06135	COG0542	response to heat
MGAS10270_RS06140	COG0494	nUDIX hydrolase
MGAS10270_RS06155	COG3599	regulation of cell shape
MGAS10270_RS06160	COG2302	S4 RNA-binding domain
MGAS10270_RS06175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS10270_RS06200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MGAS10270_RS06210	COG1217	gtp-binding protein TYPA
MGAS10270_RS06215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS10270_RS06220	COG1940	carbohydrate kinase activity
MGAS10270_RS06230	COG0783	Belongs to the Dps family
MGAS10270_RS06245	COG4470	Protein conserved in bacteria
MGAS10270_RS06250	COG1609	Transcriptional regulator
MGAS10270_RS06255	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS10270_RS06265	COG0742	ribosomal rna small subunit methyltransferase
MGAS10270_RS06275	COG0549	Belongs to the carbamate kinase family
MGAS10270_RS06280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS10270_RS06285	COG1288	antiporter activity
MGAS10270_RS06325	COG2972	Histidine kinase
MGAS10270_RS06510	COG1475	DNA binding
MGAS10270_RS06585	COG3935	DnaD domain protein
MGAS10270_RS06615	COG3561	AntA/AntB antirepressor
MGAS10270_RS06625	COG1396	sequence-specific DNA binding
MGAS10270_RS06650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS10270_RS06655	COG0785	Cytochrome C biogenesis protein
MGAS10270_RS06660	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS10270_RS06765	COG0433	COG0433 Predicted ATPase
MGAS10270_RS06815	COG1674	ftsk spoiiie
MGAS10270_RS06855	COG1396	sequence-specific DNA binding
MGAS10270_RS06890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS10270_RS06890	COG1605	Chorismate mutase
MGAS10270_RS06910	COG2226	methyltransferase
MGAS10270_RS06920	COG3250	beta-galactosidase activity
MGAS10270_RS06925	COG2207	Transcriptional regulator
MGAS10270_RS06925	COG4753	response regulator
MGAS10270_RS06940	COG1653	transport
MGAS10270_RS06945	COG0395	ABC-type sugar transport system, permease component
MGAS10270_RS06950	COG1175	transmembrane transport
MGAS10270_RS06960	COG2723	6-phospho-beta-galactosidase activity
MGAS10270_RS06965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS10270_RS06980	COG0383	alpha-mannosidase activity
MGAS10270_RS07070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS10270_RS07075	COG1739	Uncharacterized protein family UPF0029
MGAS10270_RS07085	COG1098	S1 RNA binding domain
MGAS10270_RS07095	COG2197	response regulator
MGAS10270_RS07100	COG4585	Histidine kinase
MGAS10270_RS07110	COG2815	serine threonine protein kinase
MGAS10270_RS07110	COG0515	serine threonine protein kinase
MGAS10270_RS07120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS10270_RS07120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS10270_RS07130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS10270_RS07155	COG0183	Belongs to the thiolase family
MGAS10270_RS07160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS10270_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10270_RS07175	COG2610	gluconate transmembrane transporter activity
MGAS10270_RS07190	COG0116	Belongs to the methyltransferase superfamily
MGAS10270_RS07210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS10270_RS07215	COG3579	cysteine-type endopeptidase activity
MGAS10270_RS07225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS10270_RS07230	COG1113	amino acid transport
MGAS10270_RS07235	COG0492	ferredoxin-NADP+ reductase activity
MGAS10270_RS07245	COG1126	abc transporter atp-binding protein
MGAS10270_RS07255	COG0513	Belongs to the DEAD box helicase family
MGAS10270_RS07265	COG0768	penicillin binding
MGAS10270_RS07300	COG1131	(ABC) transporter
MGAS10270_RS07325	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS10270_RS07330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS10270_RS07365	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS10270_RS07370	COG0656	L-ascorbic acid biosynthetic process
MGAS10270_RS07400	COG0561	phosphatase activity
MGAS10270_RS07405	COG2860	membrane
MGAS10270_RS07455	COG2217	Heavy metal translocating P-type atpase
MGAS10270_RS07485	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS10270_RS07490	COG0195	Participates in both transcription termination and antitermination
MGAS10270_RS07515	COG4473	ABC transporter
MGAS10270_RS07520	COG1131	(ABC) transporter
MGAS10270_RS07525	COG0537	adenosine 5'-monophosphoramidase activity
MGAS10270_RS07535	COG1316	TRANSCRIPTIONal
MGAS10270_RS07545	COG0802	atpase or kinase
MGAS10270_RS07550	COG2252	PERMEase
MGAS10270_RS07555	COG0561	phosphatase activity
MGAS10270_RS07565	COG3715	PTS system
MGAS10270_RS07570	COG3716	PTS system mannose fructose sorbose family IID component
MGAS10270_RS07610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS10270_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10270_RS07620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS10270_RS07645	COG1024	Enoyl-CoA hydratase
MGAS10270_RS07650	COG0484	heat shock protein binding
MGAS10270_RS07680	COG0588	phosphoglycerate mutase activity
MGAS10270_RS07685	COG2261	transglycosylase associated protein
MGAS10270_RS07710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS10270_RS07710	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS10270_RS07715	COG1335	isochorismatase
MGAS10270_RS07725	COG0436	Aminotransferase
MGAS10270_RS07735	COG0561	phosphatase activity
MGAS10270_RS07740	COG0252	asparaginase activity
MGAS10270_RS07755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS10270_RS07760	COG1129	ABC transporter
MGAS10270_RS07775	COG1132	(ABC) transporter
MGAS10270_RS07780	COG4988	ABC transporter
MGAS10270_RS07785	COG1120	ATPase activity
MGAS10270_RS07810	COG1388	LysM domain
MGAS10270_RS07810	COG3942	CHAP domain
MGAS10270_RS07835	COG5433	transposase activity
MGAS10270_RS07840	COG1482	cell wall glycoprotein biosynthetic process
MGAS10270_RS07845	COG1940	carbohydrate kinase activity
MGAS10270_RS07855	COG2190	(PTS) system
MGAS10270_RS07855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10270_RS07855	COG1263	PTS System
MGAS10270_RS07860	COG1621	beta-fructofuranosidase activity
MGAS10270_RS07865	COG1609	Transcriptional regulator
MGAS10270_RS07885	COG2131	deaminase
MGAS10270_RS07890	COG0006	proline dipeptidase activity
MGAS10270_RS07930	COG1194	a g-specific adenine glycosylase
MGAS10270_RS07940	COG3118	belongs to the thioredoxin family
MGAS10270_RS07970	COG0681	Belongs to the peptidase S26 family
MGAS10270_RS07975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS10270_RS07990	COG1882	Formate acetyltransferase
MGAS10270_RS07995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS10270_RS08010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS10270_RS08015	COG2814	Major facilitator Superfamily
MGAS10270_RS08020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS10270_RS08045	COG0789	Transcriptional regulator
MGAS10270_RS08065	COG0577	efflux transmembrane transporter activity
MGAS10270_RS08065	COG1136	(ABC) transporter
MGAS10270_RS08080	COG2081	HI0933 family
MGAS10270_RS08090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS10270_RS08095	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS10270_RS08115	COG0456	acetyltransferase
MGAS10270_RS08120	COG1214	PFAM Peptidase M22, glycoprotease
MGAS10270_RS08135	COG0174	glutamine synthetase
MGAS10270_RS08140	COG0789	Transcriptional regulator
MGAS10270_RS08155	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS10270_RS08210	COG0668	transmembrane transport
MGAS10270_RS08220	COG4720	Psort location CytoplasmicMembrane, score
MGAS10270_RS08225	COG0351	phosphomethylpyrimidine kinase
MGAS10270_RS08270	COG1929	Belongs to the glycerate kinase type-1 family
MGAS10270_RS08275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS10270_RS08305	COG0577	efflux transmembrane transporter activity
MGAS10270_RS08310	COG1136	(ABC) transporter
MGAS10270_RS08335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10270_RS08335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10270_RS08340	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS10270_RS08385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS10270_RS08390	COG1476	TRANSCRIPTIONal
MGAS10270_RS08410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS10270_RS08420	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS10270_RS08440	COG1045	serine acetyltransferase
MGAS10270_RS08455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS10270_RS08460	COG3037	sugar-specific permease SgaT UlaA
MGAS10270_RS08470	COG3711	transcriptional antiterminator
MGAS10270_RS08495	COG1846	Transcriptional regulator
MGAS10270_RS08515	COG4589	Belongs to the CDS family
MGAS10270_RS08525	COG1862	Preprotein translocase
MGAS10270_RS08540	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS10270_RS08550	COG3842	ATPase activity
MGAS10270_RS08590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10270_RS08590	COG2190	(PTS) system
MGAS10270_RS08590	COG1263	PTS System
MGAS10270_RS08595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS10270_RS08625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS10270_RS08630	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS10270_RS08635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS10270_RS08670	COG0601	transmembrane transport
MGAS10270_RS08700	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS10270_RS08730	COG3711	transcriptional antiterminator
MGAS10270_RS08740	COG3942	CHAP domain
MGAS10270_RS08740	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10270_RS08745	COG2205	protein histidine kinase activity
MGAS10270_RS08750	COG0745	RESPONSE REGULATOR receiver
MGAS10270_RS08755	COG0577	efflux transmembrane transporter activity
MGAS10270_RS08760	COG1136	(ABC) transporter
MGAS10270_RS08820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS10270_RS08835	COG1882	Formate acetyltransferase
MGAS10270_RS08840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10270_RS08845	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10270_RS08850	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS10270_RS08855	COG2390	Transcriptional regulator
MGAS10270_RS08860	COG1349	DNA-binding transcription factor activity
MGAS10270_RS08880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS10270_RS08895	COG0564	pseudouridine synthase activity
MGAS10270_RS08925	COG0542	response to heat
MGAS10270_RS08930	COG4463	regulation of RNA biosynthetic process
MGAS10270_RS08945	COG0450	alkyl hydroperoxide reductase
MGAS10270_RS08960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS10270_RS08970	COG3404	Formiminotransferase-cyclodeaminase
MGAS10270_RS08985	COG0531	amino acid
MGAS10270_RS09015	COG3590	peptidase
MGAS10270_RS09020	COG0366	Alpha amylase catalytic
MGAS10270_RS09025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10270_RS09025	COG1263	PTS System
MGAS10270_RS09030	COG2188	Transcriptional regulator
MGAS10270_RS09050	COG0602	queuosine metabolic process
MGAS10270_RS09065	COG1328	CTP reductase activity
MGAS10270_RS09090	COG1393	Belongs to the ArsC family
MGAS10270_RS09105	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS10270_RS09125	COG0582	viral genome integration into host DNA
MGAS10270_RS09260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10270_RS09265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10270_RS09270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10270_RS09370	COG1511	domain protein
MGAS10270_RS09495	COG0582	viral genome integration into host DNA
MGAS10270_RS09510	COG0305	Participates in initiation and elongation during chromosome replication
MGAS10270_RS09540	COG1760	l-serine dehydratase
MGAS10270_RS09545	COG1760	l-serine dehydratase
MGAS10270_RS09550	COG0741	lytic transglycosylase activity
MGAS10270_RS09555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS10270_RS09570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS10270_RS09580	COG0612	Peptidase, M16
MGAS10270_RS09600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MGAS10270_RS09620	COG0517	IMP dehydrogenase activity
MGAS10270_RS09620	COG0516	GMP reductase activity
MGAS10270_RS09630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10270_RS09635	COG0488	(ABC) transporter
MGAS10270_RS09670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS10270_RS09675	COG1475	DNA binding