locus-tag	class	description
M6_RS00010	COG0592	DNA-directed DNA polymerase activity
M6_RS00020	COG0012	GTP binding
M6_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M6_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M6_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M6_RS00070	COG0531	amino acid
M6_RS00245	COG3942	CHAP domain
M6_RS00360	COG1783	phage Terminase large subunit
M6_RS00480	COG1388	LysM domain
M6_RS00480	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6_RS00505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6_RS00515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M6_RS00530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M6_RS00550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M6_RS00555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M6_RS00565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M6_RS00580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M6_RS00595	COG1012	belongs to the aldehyde dehydrogenase family
M6_RS00595	COG1454	alcohol dehydrogenase
M6_RS00600	COG1064	alcohol dehydrogenase
M6_RS00605	COG0534	Mate efflux family protein
M6_RS00715	COG0201	protein transport
M6_RS00850	COG1121	(ABC) transporter
M6_RS00855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6_RS00870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6_RS00890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M6_RS00895	COG1459	type II secretion system
M6_RS00900	COG4537	Required for transformation and DNA binding
M6_RS00940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6_RS00945	COG1363	Peptidase, m42
M6_RS00960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6_RS00965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6_RS00980	COG1428	Deoxynucleoside kinase
M6_RS00985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6_RS01025	COG2031	fatty acid transporter
M6_RS01040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M6_RS01055	COG0251	oxidation-reduction process
M6_RS01070	COG1269	ATP hydrolysis coupled proton transport
M6_RS01075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M6_RS01085	COG1527	subunit (C
M6_RS01090	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M6_RS01125	COG1744	ABC transporter substrate-binding protein PnrA-like
M6_RS01160	COG0626	cystathionine gamma-synthase activity
M6_RS01190	COG3623	hexulose-6-phosphate isomerase
M6_RS01210	COG3448	diguanylate cyclase activity
M6_RS01210	COG4175	Glycine betaine
M6_RS01220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6_RS01220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6_RS01245	COG1268	BioY protein
M6_RS01250	COG1234	tRNA 3'-trailer cleavage
M6_RS01280	COG0457	Tetratricopeptide repeat
M6_RS01280	COG0705	Rhomboid family
M6_RS01300	COG1132	(ABC) transporter
M6_RS01305	COG1132	(ABC) transporter
M6_RS01315	COG0756	dUTP diphosphatase activity
M6_RS01340	COG3290	protein histidine kinase activity
M6_RS01365	COG1847	R3H domain protein
M6_RS01385	COG1175	transmembrane transport
M6_RS01390	COG0395	ABC-type sugar transport system, permease component
M6_RS01400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6_RS01415	COG0084	hydrolase, TatD family'
M6_RS01440	COG1564	THIamine pyrophosphokinase
M6_RS01455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M6_RS01490	COG0765	amino acid transport
M6_RS01510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M6_RS01520	COG0719	Fe-S assembly protein
M6_RS01525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M6_RS01540	COG1686	Belongs to the peptidase S11 family
M6_RS01545	COG1686	Belongs to the peptidase S11 family
M6_RS01550	COG4166	transmembrane transport
M6_RS01555	COG0601	transmembrane transport
M6_RS01560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6_RS01565	COG0444	Belongs to the ABC transporter superfamily
M6_RS01615	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M6_RS01620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M6_RS01625	COG1534	Rna-binding protein
M6_RS01635	COG1713	HD superfamily hydrolase involved in NAD metabolism
M6_RS01640	COG0799	negative regulation of ribosome biogenesis
M6_RS01645	COG2226	methyltransferase
M6_RS01660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6_RS01665	COG1464	Belongs to the NlpA lipoprotein family
M6_RS01680	COG1114	Component of the transport system for branched-chain amino acids
M6_RS01690	COG0569	domain protein
M6_RS01695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6_RS01705	COG1704	LemA family
M6_RS01720	COG0745	RESPONSE REGULATOR receiver
M6_RS01740	COG1484	DNA-dependent DNA replication
M6_RS01750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6_RS01770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M6_RS01785	COG1254	Belongs to the acylphosphatase family
M6_RS01790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6_RS01845	COG1187	pseudouridine synthase activity
M6_RS01860	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M6_RS01865	COG0671	phosphoesterase, PA-phosphatase related
M6_RS01870	COG1242	4 iron, 4 sulfur cluster binding
M6_RS01875	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M6_RS01880	COG1253	flavin adenine dinucleotide binding
M6_RS01885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M6_RS01900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6_RS01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6_RS01910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6_RS01915	COG1120	ATPase activity
M6_RS01925	COG2244	polysaccharide biosynthetic process
M6_RS01950	COG0470	DNA polymerase III
M6_RS01985	COG1393	Belongs to the ArsC family
M6_RS01990	COG0708	Exodeoxyribonuclease III
M6_RS02000	COG1304	FMN binding
M6_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
M6_RS02065	COG0673	inositol 2-dehydrogenase activity
M6_RS02080	COG0494	nUDIX hydrolase
M6_RS02090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M6_RS02195	COG1702	phosphate starvation-inducible protein PhoH
M6_RS02200	COG1573	uracil-dna glycosylase
M6_RS02210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M6_RS02235	COG3328	transposase activity
M6_RS02240	COG3328	transposase activity
M6_RS02315	COG2814	Major facilitator Superfamily
M6_RS02325	COG0557	exoribonuclease II activity
M6_RS02355	COG0463	Glycosyl transferase, family 2
M6_RS02365	COG0778	Nitroreductase
M6_RS02370	COG0006	proline dipeptidase activity
M6_RS02375	COG1609	Transcriptional regulator
M6_RS02385	COG0438	transferase activity, transferring glycosyl groups
M6_RS02395	COG4555	ABC transporter
M6_RS02420	COG2376	Dihydroxyacetone kinase
M6_RS02425	COG1461	Dihydroxyacetone kinase
M6_RS02430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M6_RS02435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6_RS02445	COG0183	Belongs to the thiolase family
M6_RS02460	COG0745	RESPONSE REGULATOR receiver
M6_RS02465	COG5002	protein histidine kinase activity
M6_RS02470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M6_RS02480	COG1196	nuclear chromosome segregation
M6_RS02490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M6_RS02570	COG4695	Portal protein
M6_RS02580	COG0561	phosphatase activity
M6_RS02585	COG0561	phosphatase activity
M6_RS02590	COG0552	protein localization to endoplasmic reticulum
M6_RS02595	COG0477	Major facilitator Superfamily
M6_RS02600	COG3711	transcriptional antiterminator
M6_RS02605	COG2190	(PTS) system
M6_RS02605	COG1263	PTS System
M6_RS02605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6_RS02615	COG3689	TIGRFAM TIGR03943 family protein
M6_RS02620	COG0701	Predicted permease
M6_RS02630	COG2183	response to ionizing radiation
M6_RS02675	COG0826	peptidase U32
M6_RS02680	COG4443	Transcriptional Coactivator p15 (PC4)
M6_RS02730	COG0386	Belongs to the glutathione peroxidase family
M6_RS02735	COG1164	Oligoendopeptidase f
M6_RS02745	COG0772	Belongs to the SEDS family
M6_RS02780	COG1078	dGTPase activity
M6_RS02795	COG1609	Transcriptional regulator
M6_RS02805	COG3716	PTS system mannose fructose sorbose family IID component
M6_RS02810	COG3715	PTS system
M6_RS02815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
M6_RS02845	COG0800	Aldolase
M6_RS02850	COG0546	phosphoglycolate phosphatase activity
M6_RS02855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M6_RS02865	COG2884	Cell division ATP-binding protein ftsE
M6_RS02870	COG2177	Part of the ABC transporter FtsEX involved in
M6_RS02885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M6_RS02885	COG1199	ATP-dependent helicase activity
M6_RS02890	COG0436	Aminotransferase
M6_RS02925	COG2188	Transcriptional regulator
M6_RS02930	COG2222	sugar isomerase
M6_RS02940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M6_RS02945	COG0716	FMN binding
M6_RS02955	COG0038	chloride channel
M6_RS03025	COG1131	(ABC) transporter
M6_RS03045	COG4708	membrane
M6_RS03055	COG1597	lipid kinase activity
M6_RS03140	COG0577	efflux transmembrane transporter activity
M6_RS03150	COG2321	neutral zinc metallopeptidase
M6_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6_RS03175	COG1970	mechanosensitive ion channel activity
M6_RS03180	COG0358	DNA primase activity
M6_RS03185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M6_RS03190	COG2151	metal-sulfur cluster biosynthetic enzyme
M6_RS03235	COG1216	Glycosyl transferase, family 2
M6_RS03290	COG1368	sulfuric ester hydrolase activity
M6_RS03295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M6_RS03315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6_RS03320	COG0285	dihydrofolate synthase activity
M6_RS03330	COG1104	cysteine desulfurase activity
M6_RS03360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M6_RS03365	COG0583	DNA-binding transcription factor activity
M6_RS03375	COG0564	pseudouridine synthase activity
M6_RS03405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6_RS03410	COG1136	(ABC) transporter
M6_RS03415	COG0577	efflux transmembrane transporter activity
M6_RS03420	COG0584	glycerophosphoryl diester phosphodiesterase
M6_RS03430	COG1837	Belongs to the UPF0109 family
M6_RS03470	COG0730	response to heat
M6_RS03480	COG1349	DNA-binding transcription factor activity
M6_RS03485	COG1105	Belongs to the carbohydrate kinase PfkB family
M6_RS03490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6_RS03490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6_RS03490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6_RS03495	COG1388	LysM domain
M6_RS03495	COG1705	Flagellar rod assembly protein muramidase FlgJ
M6_RS03500	COG1705	Flagellar rod assembly protein muramidase FlgJ
M6_RS03500	COG1388	LysM domain
M6_RS03520	COG0105	UTP biosynthetic process
M6_RS03540	COG0488	(ABC) transporter
M6_RS03550	COG0242	peptide deformylase activity
M6_RS03555	COG0737	Belongs to the 5'-nucleotidase family
M6_RS03560	COG2357	RelA SpoT domain protein
M6_RS03565	COG0745	RESPONSE REGULATOR receiver
M6_RS03600	COG3425	synthase
M6_RS03610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M6_RS03655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M6_RS03670	COG0583	DNA-binding transcription factor activity
M6_RS03695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6_RS03700	COG0765	amino acid transport
M6_RS03720	COG0187	DNA topoisomerase II activity
M6_RS03730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6_RS03750	COG0539	negative regulation of cytoplasmic translation
M6_RS03765	COG2801	Transposase and inactivated derivatives
M6_RS03840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6_RS03845	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M6_RS03855	COG0300	oxidoreductase activity
M6_RS03860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M6_RS03860	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M6_RS03875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M6_RS03880	COG2384	SAM-dependent methyltransferase
M6_RS03890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6_RS03895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M6_RS03905	COG1088	dTDP-glucose 4,6-dehydratase activity
M6_RS03910	COG1051	belongs to the nudix hydrolase family
M6_RS03915	COG0628	permease
M6_RS03925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M6_RS03940	COG1129	ABC transporter
M6_RS03960	COG0488	(ABC) transporter
M6_RS03965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6_RS03970	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6_RS03970	COG0022	dehydrogenase e1 component
M6_RS03975	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6_RS03990	COG5492	domain, Protein
M6_RS03995	COG0095	Lipoate-protein ligase
M6_RS04000	COG3442	glutamine amidotransferase
M6_RS04005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M6_RS04010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M6_RS04030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6_RS04040	COG0647	UMP catabolic process
M6_RS04085	COG3715	PTS system
M6_RS04090	COG3716	PTS system mannose fructose sorbose family IID component
M6_RS04095	COG2972	Histidine kinase
M6_RS04100	COG4753	response regulator
M6_RS04100	COG2207	Transcriptional regulator
M6_RS04110	COG1012	belongs to the aldehyde dehydrogenase family
M6_RS04125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6_RS04160	COG0285	dihydrofolate synthase activity
M6_RS04195	COG1176	ABC-type spermidine putrescine transport system, permease component I
M6_RS04200	COG1177	transmembrane transport
M6_RS04210	COG4565	transcriptional regulatory protein
M6_RS04215	COG3290	protein histidine kinase activity
M6_RS04220	COG3493	citrate carrier protein
M6_RS04235	COG3700	Belongs to the class B bacterial acid phosphatase family
M6_RS04240	COG0038	chloride channel
M6_RS04260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M6_RS04275	COG1104	cysteine desulfurase activity
M6_RS04290	COG2357	RelA SpoT domain protein
M6_RS04300	COG0564	pseudouridine synthase activity
M6_RS04305	COG0280	phosphate acetyltransferase
M6_RS04310	COG4221	oxidoreductase activity
M6_RS04325	COG1174	glycine betaine transport
M6_RS04340	COG2233	PERMEase
M6_RS04365	COG2890	protein-(glutamine-N5) methyltransferase activity
M6_RS04400	COG1132	(ABC) transporter
M6_RS04420	COG3764	Sortase (surface protein transpeptidase)
M6_RS04425	COG0346	lactoylglutathione lyase activity
M6_RS04440	COG1272	protein, Hemolysin III
M6_RS04460	COG0758	DNA mediated transformation
M6_RS04465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M6_RS04485	COG0511	ligase activity, forming carbon-carbon bonds
M6_RS04490	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M6_RS04505	COG2851	Citrate transporter
M6_RS04515	COG0511	ligase activity, forming carbon-carbon bonds
M6_RS04520	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M6_RS04555	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
M6_RS04575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M6_RS04585	COG2188	Transcriptional regulator
M6_RS04605	COG0488	(ABC) transporter
M6_RS04615	COG0351	phosphomethylpyrimidine kinase
M6_RS04615	COG0352	thiamine-phosphate diphosphorylase activity
M6_RS04620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6_RS04625	COG1328	CTP reductase activity
M6_RS04625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M6_RS04630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6_RS04660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6_RS04670	COG0095	Lipoate-protein ligase
M6_RS04680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M6_RS04685	COG4684	Psort location CytoplasmicMembrane, score
M6_RS04690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M6_RS04695	COG1079	Belongs to the binding-protein-dependent transport system permease family
M6_RS04700	COG4603	Belongs to the binding-protein-dependent transport system permease family
M6_RS04705	COG3845	ABC transporter
M6_RS04710	COG1744	ABC transporter substrate-binding protein PnrA-like
M6_RS04715	COG0295	cytidine deaminase activity
M6_RS04720	COG2813	Specifically methylates the guanine in position
M6_RS04735	COG5002	protein histidine kinase activity
M6_RS04740	COG0745	RESPONSE REGULATOR receiver
M6_RS04750	COG0704	Plays a role in the regulation of phosphate uptake
M6_RS04765	COG0581	inorganic phosphate transmembrane transporter activity
M6_RS04770	COG0573	inorganic phosphate transmembrane transporter activity
M6_RS04780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6_RS04780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M6_RS04785	COG0483	inositol monophosphate 1-phosphatase activity
M6_RS04800	COG0196	riboflavin kinase activity
M6_RS04830	COG1136	(ABC) transporter
M6_RS04830	COG4591	ABC-type transport system involved in lipoprotein release permease component
M6_RS04880	COG1115	amino acid carrier protein
M6_RS04885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M6_RS04890	COG3711	transcriptional antiterminator
M6_RS04895	COG2213	PTS system mannitol-specific
M6_RS04915	COG0469	pyruvate kinase activity
M6_RS04930	COG1725	Transcriptional regulator
M6_RS04935	COG1131	(ABC) transporter
M6_RS04970	COG1388	LysM domain
M6_RS04970	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6_RS04980	COG1705	Flagellar rod assembly protein muramidase FlgJ
M6_RS04990	COG4824	toxin secretion phage lysis holin
M6_RS05170	COG0058	SHG alpha-glucan phosphorylase activity
M6_RS05175	COG1640	4-alpha-glucanotransferase
M6_RS05180	COG1609	Transcriptional regulator
M6_RS05185	COG2182	Extracellular solute-binding protein
M6_RS05190	COG1175	transmembrane transport
M6_RS05195	COG3833	ABC-type maltose transport systems, permease component
M6_RS05210	COG0657	acetylesterase activity
M6_RS05215	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M6_RS05225	COG1696	Membrane protein involved in D-alanine export
M6_RS05245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6_RS05250	COG1126	abc transporter atp-binding protein
M6_RS05255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6_RS05265	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6_RS05275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6_RS05275	COG3711	transcriptional antiterminator
M6_RS05285	COG2723	6-phospho-beta-galactosidase activity
M6_RS05310	COG2801	Transposase and inactivated derivatives
M6_RS05315	COG0157	Belongs to the NadC ModD family
M6_RS05330	COG1187	pseudouridine synthase activity
M6_RS05340	COG2814	Major facilitator Superfamily
M6_RS05390	COG4109	DRTGG domain
M6_RS05430	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M6_RS05430	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M6_RS05435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M6_RS05440	COG1956	GAF domain-containing protein
M6_RS05460	COG0513	Belongs to the DEAD box helicase family
M6_RS05465	COG0726	polysaccharide deacetylase
M6_RS05485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M6_RS05490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6_RS05510	COG2801	Transposase and inactivated derivatives
M6_RS05515	COG2801	Transposase and inactivated derivatives
M6_RS05520	COG2801	Transposase and inactivated derivatives
M6_RS05535	COG1476	TRANSCRIPTIONal
M6_RS05550	COG4122	O-methyltransferase activity
M6_RS05555	COG2223	nitrite transmembrane transporter activity
M6_RS05570	COG1187	pseudouridine synthase activity
M6_RS05610	COG0658	competence protein
M6_RS05610	COG2333	competence protein COMEC
M6_RS05705	COG0740	serine-type endopeptidase activity
M6_RS05710	COG4695	Portal protein
M6_RS05735	COG0270	DNA (cytosine-5-)-methyltransferase activity
M6_RS05755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M6_RS05805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6_RS05805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6_RS05845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M6_RS05860	COG0488	(ABC) transporter
M6_RS05915	COG1555	photosystem II stabilization
M6_RS05920	COG0204	Acyl-transferase
M6_RS05925	COG2890	protein-(glutamine-N5) methyltransferase activity
M6_RS05940	COG0513	Belongs to the DEAD box helicase family
M6_RS05955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M6_RS05975	COG2116	formate transmembrane transporter activity
M6_RS05985	COG1827	regulation of RNA biosynthetic process
M6_RS06000	COG2217	Heavy metal translocating P-type atpase
M6_RS06035	COG4824	toxin secretion phage lysis holin
M6_RS06205	COG3723	Recombinational DNA repair protein, rece pathway
M6_RS06230	COG0582	viral genome integration into host DNA
M6_RS06245	COG2755	lipolytic protein G-D-S-L family
M6_RS06260	COG0497	DNA recombination
M6_RS06265	COG1438	arginine binding
M6_RS06270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M6_RS06295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M6_RS06310	COG0765	amino acid transport
M6_RS06315	COG4703	Protein of unknown function (DUF1797)
M6_RS06320	COG0542	response to heat
M6_RS06325	COG0494	nUDIX hydrolase
M6_RS06340	COG3599	regulation of cell shape
M6_RS06345	COG2302	S4 RNA-binding domain
M6_RS06360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M6_RS06395	COG1217	gtp-binding protein TYPA
M6_RS06400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6_RS06405	COG1940	carbohydrate kinase activity
M6_RS06415	COG0783	Belongs to the Dps family
M6_RS06430	COG4470	Protein conserved in bacteria
M6_RS06440	COG3480	Lon protease (S16) C-terminal proteolytic domain
M6_RS06450	COG0742	ribosomal rna small subunit methyltransferase
M6_RS06460	COG0549	Belongs to the carbamate kinase family
M6_RS06465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6_RS06470	COG1288	antiporter activity
M6_RS06480	COG0454	-acetyltransferase
M6_RS06485	COG2235	arginine
M6_RS06510	COG2972	Histidine kinase
M6_RS06525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6_RS06530	COG0785	Cytochrome C biogenesis protein
M6_RS06540	COG0673	inositol 2-dehydrogenase activity
M6_RS06585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M6_RS06585	COG1605	Chorismate mutase
M6_RS06605	COG2226	methyltransferase
M6_RS06615	COG3250	beta-galactosidase activity
M6_RS06620	COG2207	Transcriptional regulator
M6_RS06620	COG4753	response regulator
M6_RS06625	COG2972	Histidine kinase
M6_RS06635	COG1653	transport
M6_RS06640	COG0395	ABC-type sugar transport system, permease component
M6_RS06645	COG1175	transmembrane transport
M6_RS06650	COG1940	carbohydrate kinase activity
M6_RS06655	COG2723	6-phospho-beta-galactosidase activity
M6_RS06660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M6_RS06675	COG0383	alpha-mannosidase activity
M6_RS06710	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6_RS06710	COG1388	LysM domain
M6_RS06910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M6_RS06915	COG1739	Uncharacterized protein family UPF0029
M6_RS06925	COG1098	S1 RNA binding domain
M6_RS06935	COG2197	response regulator
M6_RS06940	COG4585	Histidine kinase
M6_RS06950	COG0515	serine threonine protein kinase
M6_RS06950	COG2815	serine threonine protein kinase
M6_RS06960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6_RS06960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6_RS06970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M6_RS06990	COG0583	DNA-binding transcription factor activity
M6_RS06995	COG0183	Belongs to the thiolase family
M6_RS07000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M6_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
M6_RS07015	COG2610	gluconate transmembrane transporter activity
M6_RS07030	COG0116	Belongs to the methyltransferase superfamily
M6_RS07050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6_RS07055	COG3579	cysteine-type endopeptidase activity
M6_RS07065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M6_RS07070	COG1113	amino acid transport
M6_RS07075	COG0492	ferredoxin-NADP+ reductase activity
M6_RS07085	COG1126	abc transporter atp-binding protein
M6_RS07095	COG0513	Belongs to the DEAD box helicase family
M6_RS07105	COG0768	penicillin binding
M6_RS07140	COG1131	(ABC) transporter
M6_RS07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
M6_RS07170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6_RS07205	COG1755	Isoprenylcysteine carboxyl methyltransferase
M6_RS07210	COG0656	L-ascorbic acid biosynthetic process
M6_RS07220	COG1283	sodium-dependent phosphate transmembrane transporter activity
M6_RS07240	COG0561	phosphatase activity
M6_RS07245	COG2860	membrane
M6_RS07295	COG2217	Heavy metal translocating P-type atpase
M6_RS07325	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M6_RS07330	COG0195	Participates in both transcription termination and antitermination
M6_RS07355	COG4473	ABC transporter
M6_RS07360	COG1131	(ABC) transporter
M6_RS07365	COG0537	adenosine 5'-monophosphoramidase activity
M6_RS07375	COG1316	TRANSCRIPTIONal
M6_RS07385	COG0802	atpase or kinase
M6_RS07390	COG2252	PERMEase
M6_RS07395	COG0561	phosphatase activity
M6_RS07405	COG3715	PTS system
M6_RS07410	COG3716	PTS system mannose fructose sorbose family IID component
M6_RS07435	COG0439	Biotin carboxylase
M6_RS07450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M6_RS07455	COG1028	Short-chain dehydrogenase reductase Sdr
M6_RS07460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M6_RS07485	COG1024	Enoyl-CoA hydratase
M6_RS07520	COG0588	phosphoglycerate mutase activity
M6_RS07525	COG2261	transglycosylase associated protein
M6_RS07550	COG0574	Belongs to the PEP-utilizing enzyme family
M6_RS07550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M6_RS07555	COG1335	isochorismatase
M6_RS07565	COG0436	Aminotransferase
M6_RS07575	COG0561	phosphatase activity
M6_RS07580	COG0252	asparaginase activity
M6_RS07595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M6_RS07600	COG1129	ABC transporter
M6_RS07615	COG1132	(ABC) transporter
M6_RS07620	COG4988	ABC transporter
M6_RS07625	COG1120	ATPase activity
M6_RS07650	COG3942	CHAP domain
M6_RS07650	COG1388	LysM domain
M6_RS07675	COG1482	cell wall glycoprotein biosynthetic process
M6_RS07680	COG1940	carbohydrate kinase activity
M6_RS07690	COG1263	PTS System
M6_RS07690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6_RS07690	COG2190	(PTS) system
M6_RS07695	COG1621	beta-fructofuranosidase activity
M6_RS07700	COG1609	Transcriptional regulator
M6_RS07720	COG2131	deaminase
M6_RS07725	COG0006	proline dipeptidase activity
M6_RS07880	COG1194	a g-specific adenine glycosylase
M6_RS07890	COG3118	belongs to the thioredoxin family
M6_RS07920	COG0681	Belongs to the peptidase S26 family
M6_RS07925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M6_RS07940	COG1882	Formate acetyltransferase
M6_RS07945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6_RS07960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6_RS07965	COG2814	Major facilitator Superfamily
M6_RS07970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6_RS08010	COG2081	HI0933 family
M6_RS08020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6_RS08025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M6_RS08045	COG0456	acetyltransferase
M6_RS08050	COG1214	PFAM Peptidase M22, glycoprotease
M6_RS08065	COG0174	glutamine synthetase
M6_RS08070	COG0789	Transcriptional regulator
M6_RS08085	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M6_RS08140	COG0668	transmembrane transport
M6_RS08150	COG4720	Psort location CytoplasmicMembrane, score
M6_RS08155	COG0351	phosphomethylpyrimidine kinase
M6_RS08200	COG1929	Belongs to the glycerate kinase type-1 family
M6_RS08205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M6_RS08235	COG0577	efflux transmembrane transporter activity
M6_RS08240	COG1136	(ABC) transporter
M6_RS08265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6_RS08265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6_RS08270	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6_RS08320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M6_RS08325	COG1476	TRANSCRIPTIONal
M6_RS08345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6_RS08355	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M6_RS08375	COG1045	serine acetyltransferase
M6_RS08390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M6_RS08405	COG3711	transcriptional antiterminator
M6_RS08430	COG1846	Transcriptional regulator
M6_RS08450	COG4589	Belongs to the CDS family
M6_RS08460	COG1862	Preprotein translocase
M6_RS08470	COG1523	belongs to the glycosyl hydrolase 13 family
M6_RS08480	COG3842	ATPase activity
M6_RS08520	COG1263	PTS System
M6_RS08520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6_RS08520	COG2190	(PTS) system
M6_RS08525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M6_RS08545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M6_RS08550	COG0512	Glutamine amidotransferase of anthranilate synthase
M6_RS08555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M6_RS08585	COG0601	transmembrane transport
M6_RS08595	COG1122	ATPase activity
M6_RS08615	COG0803	Belongs to the bacterial solute-binding protein 9 family
M6_RS08630	COG3711	transcriptional antiterminator
M6_RS08640	COG3942	CHAP domain
M6_RS08640	COG1705	Flagellar rod assembly protein muramidase FlgJ
M6_RS08645	COG2205	protein histidine kinase activity
M6_RS08650	COG0745	RESPONSE REGULATOR receiver
M6_RS08655	COG0577	efflux transmembrane transporter activity
M6_RS08660	COG1136	(ABC) transporter
M6_RS08710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M6_RS08725	COG1882	Formate acetyltransferase
M6_RS08730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6_RS08735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6_RS08740	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6_RS08745	COG2390	Transcriptional regulator
M6_RS08750	COG1349	DNA-binding transcription factor activity
M6_RS08755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M6_RS08770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6_RS08785	COG0564	pseudouridine synthase activity
M6_RS08815	COG0542	response to heat
M6_RS08820	COG4463	regulation of RNA biosynthetic process
M6_RS08835	COG0450	alkyl hydroperoxide reductase
M6_RS08850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M6_RS08860	COG3404	Formiminotransferase-cyclodeaminase
M6_RS08875	COG0531	amino acid
M6_RS08910	COG3590	peptidase
M6_RS08915	COG0366	Alpha amylase catalytic
M6_RS08920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6_RS08920	COG1263	PTS System
M6_RS08925	COG2188	Transcriptional regulator
M6_RS08930	COG1733	regulation of RNA biosynthetic process
M6_RS08935	COG2514	catechol 2,3-dioxygenase activity
M6_RS08945	COG0602	queuosine metabolic process
M6_RS08960	COG1328	CTP reductase activity
M6_RS08985	COG1393	Belongs to the ArsC family
M6_RS09000	COG0519	Catalyzes the synthesis of GMP from XMP
M6_RS09020	COG0582	viral genome integration into host DNA
M6_RS09140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6_RS09145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6_RS09150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6_RS09240	COG1511	domain protein
M6_RS09260	COG0305	Participates in initiation and elongation during chromosome replication
M6_RS09285	COG1760	l-serine dehydratase
M6_RS09290	COG1760	l-serine dehydratase
M6_RS09295	COG0741	lytic transglycosylase activity
M6_RS09300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M6_RS09315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M6_RS09325	COG0612	Peptidase, M16
M6_RS09330	COG0612	Peptidase, M16
M6_RS09345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M6_RS09370	COG0516	GMP reductase activity
M6_RS09370	COG0517	IMP dehydrogenase activity
M6_RS09380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6_RS09385	COG0488	(ABC) transporter
M6_RS09420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6_RS09425	COG1475	DNA binding