locus-tag	class	description
MGAS10750_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS10750_RS00020	COG0012	GTP binding
MGAS10750_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS10750_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS10750_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS10750_RS00065	COG0531	amino acid
MGAS10750_RS00240	COG3942	CHAP domain
MGAS10750_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS10750_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS10750_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS10750_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS10750_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS10750_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS10750_RS00355	COG1454	alcohol dehydrogenase
MGAS10750_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
MGAS10750_RS00360	COG1064	alcohol dehydrogenase
MGAS10750_RS00365	COG0534	Mate efflux family protein
MGAS10750_RS00480	COG0201	protein transport
MGAS10750_RS00625	COG1121	(ABC) transporter
MGAS10750_RS00630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS10750_RS00645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS10750_RS00645	COG4499	WXG100 protein secretion system (Wss), protein YukC
MGAS10750_RS00665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS10750_RS00670	COG1459	type II secretion system
MGAS10750_RS00675	COG4537	Required for transformation and DNA binding
MGAS10750_RS00715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS10750_RS00720	COG1363	Peptidase, m42
MGAS10750_RS00730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS10750_RS00735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS10750_RS00745	COG1428	Deoxynucleoside kinase
MGAS10750_RS00750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS10750_RS00805	COG2031	fatty acid transporter
MGAS10750_RS00820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS10750_RS00835	COG0251	oxidation-reduction process
MGAS10750_RS00850	COG1269	ATP hydrolysis coupled proton transport
MGAS10750_RS00855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS10750_RS00865	COG1527	subunit (C
MGAS10750_RS00870	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS10750_RS00905	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS10750_RS00945	COG0626	cystathionine gamma-synthase activity
MGAS10750_RS00975	COG3623	hexulose-6-phosphate isomerase
MGAS10750_RS00995	COG3448	diguanylate cyclase activity
MGAS10750_RS00995	COG4175	Glycine betaine
MGAS10750_RS01005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS10750_RS01005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS10750_RS01030	COG1268	BioY protein
MGAS10750_RS01035	COG1234	tRNA 3'-trailer cleavage
MGAS10750_RS01075	COG0705	Rhomboid family
MGAS10750_RS01075	COG0457	Tetratricopeptide repeat
MGAS10750_RS01095	COG1132	(ABC) transporter
MGAS10750_RS01100	COG1132	(ABC) transporter
MGAS10750_RS01110	COG0756	dUTP diphosphatase activity
MGAS10750_RS01160	COG1847	R3H domain protein
MGAS10750_RS01180	COG1175	transmembrane transport
MGAS10750_RS01185	COG0395	ABC-type sugar transport system, permease component
MGAS10750_RS01200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS10750_RS01215	COG0084	hydrolase, TatD family'
MGAS10750_RS01240	COG1564	THIamine pyrophosphokinase
MGAS10750_RS01255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS10750_RS01290	COG0765	amino acid transport
MGAS10750_RS01310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS10750_RS01320	COG0719	Fe-S assembly protein
MGAS10750_RS01325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS10750_RS01340	COG1686	Belongs to the peptidase S11 family
MGAS10750_RS01345	COG1686	Belongs to the peptidase S11 family
MGAS10750_RS01350	COG4166	transmembrane transport
MGAS10750_RS01355	COG0601	transmembrane transport
MGAS10750_RS01360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS10750_RS01365	COG0444	Belongs to the ABC transporter superfamily
MGAS10750_RS01415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS10750_RS01420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS10750_RS01425	COG1534	Rna-binding protein
MGAS10750_RS01435	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS10750_RS01445	COG0799	negative regulation of ribosome biogenesis
MGAS10750_RS01450	COG2226	methyltransferase
MGAS10750_RS01465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10750_RS01470	COG1464	Belongs to the NlpA lipoprotein family
MGAS10750_RS01495	COG0569	domain protein
MGAS10750_RS01500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS10750_RS01510	COG1704	LemA family
MGAS10750_RS01525	COG0745	RESPONSE REGULATOR receiver
MGAS10750_RS01545	COG1484	DNA-dependent DNA replication
MGAS10750_RS01555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS10750_RS01575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS10750_RS01590	COG1254	Belongs to the acylphosphatase family
MGAS10750_RS01595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS10750_RS01650	COG1187	pseudouridine synthase activity
MGAS10750_RS01665	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS10750_RS01670	COG0671	phosphoesterase, PA-phosphatase related
MGAS10750_RS01675	COG1242	4 iron, 4 sulfur cluster binding
MGAS10750_RS01680	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS10750_RS01685	COG1253	flavin adenine dinucleotide binding
MGAS10750_RS01690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS10750_RS01705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS10750_RS01710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS10750_RS01715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS10750_RS01720	COG1120	ATPase activity
MGAS10750_RS01740	COG2244	polysaccharide biosynthetic process
MGAS10750_RS01765	COG0470	DNA polymerase III
MGAS10750_RS01795	COG1393	Belongs to the ArsC family
MGAS10750_RS01800	COG0708	Exodeoxyribonuclease III
MGAS10750_RS01810	COG1304	FMN binding
MGAS10750_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10750_RS01905	COG0673	inositol 2-dehydrogenase activity
MGAS10750_RS01920	COG0494	nUDIX hydrolase
MGAS10750_RS01930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS10750_RS02020	COG1702	phosphate starvation-inducible protein PhoH
MGAS10750_RS02025	COG1573	uracil-dna glycosylase
MGAS10750_RS02035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS10750_RS02050	COG2274	protein secretion by the type I secretion system
MGAS10750_RS02055	COG2274	protein secretion by the type I secretion system
MGAS10750_RS02090	COG2801	Transposase and inactivated derivatives
MGAS10750_RS02100	COG3279	Response regulator of the LytR AlgR family
MGAS10750_RS02115	COG2274	protein secretion by the type I secretion system
MGAS10750_RS02180	COG0433	COG0433 Predicted ATPase
MGAS10750_RS02185	COG2814	Major facilitator Superfamily
MGAS10750_RS02195	COG0557	exoribonuclease II activity
MGAS10750_RS02225	COG0463	Glycosyl transferase, family 2
MGAS10750_RS02235	COG0778	Nitroreductase
MGAS10750_RS02240	COG0006	proline dipeptidase activity
MGAS10750_RS02245	COG1609	Transcriptional regulator
MGAS10750_RS02255	COG0438	transferase activity, transferring glycosyl groups
MGAS10750_RS02280	COG2376	Dihydroxyacetone kinase
MGAS10750_RS02290	COG2376	Dihydroxyacetone kinase
MGAS10750_RS02295	COG1461	Dihydroxyacetone kinase
MGAS10750_RS02300	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MGAS10750_RS02305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS10750_RS02315	COG0183	Belongs to the thiolase family
MGAS10750_RS02330	COG0745	RESPONSE REGULATOR receiver
MGAS10750_RS02335	COG5002	protein histidine kinase activity
MGAS10750_RS02340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS10750_RS02350	COG1196	nuclear chromosome segregation
MGAS10750_RS02360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS10750_RS02500	COG0561	phosphatase activity
MGAS10750_RS02505	COG0561	phosphatase activity
MGAS10750_RS02510	COG0552	protein localization to endoplasmic reticulum
MGAS10750_RS02515	COG0477	Major facilitator Superfamily
MGAS10750_RS02520	COG3711	transcriptional antiterminator
MGAS10750_RS02525	COG1263	PTS System
MGAS10750_RS02525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10750_RS02525	COG2190	(PTS) system
MGAS10750_RS02535	COG3689	TIGRFAM TIGR03943 family protein
MGAS10750_RS02540	COG0701	Predicted permease
MGAS10750_RS02550	COG2183	response to ionizing radiation
MGAS10750_RS02595	COG0826	peptidase U32
MGAS10750_RS02600	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS10750_RS02650	COG0386	Belongs to the glutathione peroxidase family
MGAS10750_RS02655	COG1164	Oligoendopeptidase f
MGAS10750_RS02665	COG0772	Belongs to the SEDS family
MGAS10750_RS02700	COG1078	dGTPase activity
MGAS10750_RS02715	COG1609	Transcriptional regulator
MGAS10750_RS02725	COG3716	PTS system mannose fructose sorbose family IID component
MGAS10750_RS02730	COG3715	PTS system
MGAS10750_RS02735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10750_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10750_RS02765	COG0800	Aldolase
MGAS10750_RS02770	COG0546	phosphoglycolate phosphatase activity
MGAS10750_RS02775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS10750_RS02785	COG2884	Cell division ATP-binding protein ftsE
MGAS10750_RS02790	COG2177	Part of the ABC transporter FtsEX involved in
MGAS10750_RS02805	COG1199	ATP-dependent helicase activity
MGAS10750_RS02805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS10750_RS02810	COG0436	Aminotransferase
MGAS10750_RS02995	COG1598	PFAM Uncharacterised protein family UPF0150
MGAS10750_RS03035	COG0740	serine-type endopeptidase activity
MGAS10750_RS03130	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10750_RS03165	COG2188	Transcriptional regulator
MGAS10750_RS03170	COG2222	sugar isomerase
MGAS10750_RS03180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS10750_RS03185	COG0716	FMN binding
MGAS10750_RS03195	COG0038	chloride channel
MGAS10750_RS03280	COG1131	(ABC) transporter
MGAS10750_RS03300	COG4708	membrane
MGAS10750_RS03310	COG1597	lipid kinase activity
MGAS10750_RS03405	COG0577	efflux transmembrane transporter activity
MGAS10750_RS03410	COG1136	(ABC) transporter
MGAS10750_RS03415	COG2321	neutral zinc metallopeptidase
MGAS10750_RS03430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10750_RS03440	COG1970	mechanosensitive ion channel activity
MGAS10750_RS03445	COG5433	transposase activity
MGAS10750_RS03455	COG0358	DNA primase activity
MGAS10750_RS03460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS10750_RS03465	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS10750_RS03510	COG1216	Glycosyl transferase, family 2
MGAS10750_RS03565	COG1368	sulfuric ester hydrolase activity
MGAS10750_RS03570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS10750_RS03590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS10750_RS03595	COG0285	dihydrofolate synthase activity
MGAS10750_RS03605	COG1104	cysteine desulfurase activity
MGAS10750_RS03635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS10750_RS03640	COG0583	DNA-binding transcription factor activity
MGAS10750_RS03650	COG0564	pseudouridine synthase activity
MGAS10750_RS03680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS10750_RS03685	COG1136	(ABC) transporter
MGAS10750_RS03690	COG0577	efflux transmembrane transporter activity
MGAS10750_RS03695	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS10750_RS03705	COG1837	Belongs to the UPF0109 family
MGAS10750_RS03765	COG1349	DNA-binding transcription factor activity
MGAS10750_RS03770	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS10750_RS03775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS10750_RS03775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS10750_RS03775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS10750_RS03780	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10750_RS03780	COG1388	LysM domain
MGAS10750_RS03785	COG1388	LysM domain
MGAS10750_RS03785	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10750_RS03790	COG2801	Transposase and inactivated derivatives
MGAS10750_RS03805	COG0105	UTP biosynthetic process
MGAS10750_RS03825	COG0488	(ABC) transporter
MGAS10750_RS03835	COG0242	peptide deformylase activity
MGAS10750_RS03840	COG0737	Belongs to the 5'-nucleotidase family
MGAS10750_RS03845	COG2357	RelA SpoT domain protein
MGAS10750_RS03850	COG0745	RESPONSE REGULATOR receiver
MGAS10750_RS03885	COG3425	synthase
MGAS10750_RS03895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS10750_RS03950	COG0583	DNA-binding transcription factor activity
MGAS10750_RS03975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10750_RS03980	COG0765	amino acid transport
MGAS10750_RS04000	COG0187	DNA topoisomerase II activity
MGAS10750_RS04010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS10750_RS04040	COG0539	negative regulation of cytoplasmic translation
MGAS10750_RS04075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS10750_RS04080	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS10750_RS04090	COG0300	oxidoreductase activity
MGAS10750_RS04095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS10750_RS04095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS10750_RS04110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS10750_RS04115	COG2384	SAM-dependent methyltransferase
MGAS10750_RS04125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS10750_RS04130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS10750_RS04140	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS10750_RS04145	COG0582	viral genome integration into host DNA
MGAS10750_RS04260	COG1783	phage Terminase large subunit
MGAS10750_RS04410	COG1051	belongs to the nudix hydrolase family
MGAS10750_RS04415	COG0628	permease
MGAS10750_RS04420	COG0457	Tetratricopeptide repeat
MGAS10750_RS04425	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS10750_RS04440	COG1129	ABC transporter
MGAS10750_RS04460	COG0488	(ABC) transporter
MGAS10750_RS04465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS10750_RS04470	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS10750_RS04470	COG0022	dehydrogenase e1 component
MGAS10750_RS04475	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS10750_RS04490	COG5492	domain, Protein
MGAS10750_RS04495	COG0095	Lipoate-protein ligase
MGAS10750_RS04500	COG3442	glutamine amidotransferase
MGAS10750_RS04505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS10750_RS04510	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS10750_RS04530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS10750_RS04540	COG0647	UMP catabolic process
MGAS10750_RS04555	COG1518	maintenance of DNA repeat elements
MGAS10750_RS04560	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS10750_RS04575	COG0105	UTP biosynthetic process
MGAS10750_RS04610	COG3715	PTS system
MGAS10750_RS04615	COG3716	PTS system mannose fructose sorbose family IID component
MGAS10750_RS04620	COG2972	Histidine kinase
MGAS10750_RS04625	COG4753	response regulator
MGAS10750_RS04625	COG2207	Transcriptional regulator
MGAS10750_RS04635	COG1012	belongs to the aldehyde dehydrogenase family
MGAS10750_RS04650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS10750_RS04730	COG1131	(ABC) transporter
MGAS10750_RS04745	COG1396	sequence-specific DNA binding
MGAS10750_RS04785	COG0285	dihydrofolate synthase activity
MGAS10750_RS04805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS10750_RS04820	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS10750_RS04825	COG1177	transmembrane transport
MGAS10750_RS04835	COG4565	transcriptional regulatory protein
MGAS10750_RS04840	COG3290	protein histidine kinase activity
MGAS10750_RS04845	COG3493	citrate carrier protein
MGAS10750_RS04860	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS10750_RS04875	COG0628	permease
MGAS10750_RS04885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS10750_RS04900	COG1104	cysteine desulfurase activity
MGAS10750_RS04915	COG2357	RelA SpoT domain protein
MGAS10750_RS04925	COG0564	pseudouridine synthase activity
MGAS10750_RS04930	COG0280	phosphate acetyltransferase
MGAS10750_RS04935	COG4221	oxidoreductase activity
MGAS10750_RS04950	COG1174	glycine betaine transport
MGAS10750_RS04965	COG2233	PERMEase
MGAS10750_RS04990	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS10750_RS05020	COG1132	(ABC) transporter
MGAS10750_RS05025	COG1132	(ABC) transporter
MGAS10750_RS05045	COG3764	Sortase (surface protein transpeptidase)
MGAS10750_RS05050	COG0346	lactoylglutathione lyase activity
MGAS10750_RS05065	COG1272	protein, Hemolysin III
MGAS10750_RS05085	COG0758	DNA mediated transformation
MGAS10750_RS05090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS10750_RS05135	COG0511	ligase activity, forming carbon-carbon bonds
MGAS10750_RS05140	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS10750_RS05155	COG2851	Citrate transporter
MGAS10750_RS05165	COG0511	ligase activity, forming carbon-carbon bonds
MGAS10750_RS05205	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS10750_RS05225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS10750_RS05235	COG2188	Transcriptional regulator
MGAS10750_RS05255	COG0488	(ABC) transporter
MGAS10750_RS05265	COG0352	thiamine-phosphate diphosphorylase activity
MGAS10750_RS05265	COG0351	phosphomethylpyrimidine kinase
MGAS10750_RS05270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS10750_RS05275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS10750_RS05275	COG1328	CTP reductase activity
MGAS10750_RS05280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS10750_RS05310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS10750_RS05320	COG0095	Lipoate-protein ligase
MGAS10750_RS05330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS10750_RS05335	COG4684	Psort location CytoplasmicMembrane, score
MGAS10750_RS05340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS10750_RS05345	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS10750_RS05350	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS10750_RS05355	COG3845	ABC transporter
MGAS10750_RS05360	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS10750_RS05365	COG0295	cytidine deaminase activity
MGAS10750_RS05370	COG2813	Specifically methylates the guanine in position
MGAS10750_RS05385	COG5002	protein histidine kinase activity
MGAS10750_RS05390	COG0745	RESPONSE REGULATOR receiver
MGAS10750_RS05400	COG0704	Plays a role in the regulation of phosphate uptake
MGAS10750_RS05415	COG0581	inorganic phosphate transmembrane transporter activity
MGAS10750_RS05420	COG0573	inorganic phosphate transmembrane transporter activity
MGAS10750_RS05430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS10750_RS05430	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS10750_RS05450	COG0196	riboflavin kinase activity
MGAS10750_RS05480	COG1136	(ABC) transporter
MGAS10750_RS05480	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS10750_RS05530	COG1115	amino acid carrier protein
MGAS10750_RS05535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS10750_RS05545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10750_RS05550	COG1126	abc transporter atp-binding protein
MGAS10750_RS05555	COG0765	amino acid transport
MGAS10750_RS05560	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS10750_RS05575	COG0469	pyruvate kinase activity
MGAS10750_RS05590	COG1725	Transcriptional regulator
MGAS10750_RS05595	COG1131	(ABC) transporter
MGAS10750_RS05615	COG0058	SHG alpha-glucan phosphorylase activity
MGAS10750_RS05620	COG1640	4-alpha-glucanotransferase
MGAS10750_RS05625	COG1609	Transcriptional regulator
MGAS10750_RS05630	COG2182	Extracellular solute-binding protein
MGAS10750_RS05635	COG1175	transmembrane transport
MGAS10750_RS05640	COG3833	ABC-type maltose transport systems, permease component
MGAS10750_RS05655	COG3833	ABC-type maltose transport systems, permease component
MGAS10750_RS05660	COG1175	transmembrane transport
MGAS10750_RS05670	COG0366	Alpha amylase catalytic
MGAS10750_RS05675	COG2182	Extracellular solute-binding protein
MGAS10750_RS05685	COG0657	acetylesterase activity
MGAS10750_RS05690	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS10750_RS05700	COG1696	Membrane protein involved in D-alanine export
MGAS10750_RS05720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS10750_RS05725	COG1126	abc transporter atp-binding protein
MGAS10750_RS05730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10750_RS05740	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS10750_RS05750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS10750_RS05750	COG3711	transcriptional antiterminator
MGAS10750_RS05760	COG2723	6-phospho-beta-galactosidase activity
MGAS10750_RS05790	COG0157	Belongs to the NadC ModD family
MGAS10750_RS05805	COG2801	Transposase and inactivated derivatives
MGAS10750_RS05810	COG2801	Transposase and inactivated derivatives
MGAS10750_RS05815	COG1187	pseudouridine synthase activity
MGAS10750_RS05825	COG2814	Major facilitator Superfamily
MGAS10750_RS05875	COG4109	DRTGG domain
MGAS10750_RS05905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS10750_RS05905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS10750_RS05915	COG1956	GAF domain-containing protein
MGAS10750_RS05935	COG0513	Belongs to the DEAD box helicase family
MGAS10750_RS05950	COG0726	polysaccharide deacetylase
MGAS10750_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS10750_RS06010	COG2801	Transposase and inactivated derivatives
MGAS10750_RS06015	COG2801	Transposase and inactivated derivatives
MGAS10750_RS06030	COG1476	TRANSCRIPTIONal
MGAS10750_RS06045	COG4122	O-methyltransferase activity
MGAS10750_RS06050	COG2223	nitrite transmembrane transporter activity
MGAS10750_RS06065	COG1187	pseudouridine synthase activity
MGAS10750_RS06110	COG0658	competence protein
MGAS10750_RS06110	COG2333	competence protein COMEC
MGAS10750_RS06115	COG1596	polysaccharide export
MGAS10750_RS06115	COG1555	photosystem II stabilization
MGAS10750_RS06120	COG0204	Acyl-transferase
MGAS10750_RS06125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS10750_RS06140	COG0513	Belongs to the DEAD box helicase family
MGAS10750_RS06155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS10750_RS06170	COG0768	penicillin binding
MGAS10750_RS06175	COG2116	formate transmembrane transporter activity
MGAS10750_RS06185	COG1827	regulation of RNA biosynthetic process
MGAS10750_RS06200	COG2217	Heavy metal translocating P-type atpase
MGAS10750_RS06215	COG3177	Filamentation induced by cAMP protein fic
MGAS10750_RS06450	COG1396	sequence-specific DNA binding
MGAS10750_RS06460	COG0582	viral genome integration into host DNA
MGAS10750_RS06475	COG2755	lipolytic protein G-D-S-L family
MGAS10750_RS06495	COG1438	arginine binding
MGAS10750_RS06500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS10750_RS06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS10750_RS06530	COG0415	Belongs to the DNA photolyase family
MGAS10750_RS06540	COG0765	amino acid transport
MGAS10750_RS06545	COG4703	Protein of unknown function (DUF1797)
MGAS10750_RS06550	COG0542	response to heat
MGAS10750_RS06555	COG0494	nUDIX hydrolase
MGAS10750_RS06570	COG3599	regulation of cell shape
MGAS10750_RS06575	COG2302	S4 RNA-binding domain
MGAS10750_RS06590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS10750_RS06625	COG1217	gtp-binding protein TYPA
MGAS10750_RS06630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS10750_RS06635	COG1940	carbohydrate kinase activity
MGAS10750_RS06645	COG0783	Belongs to the Dps family
MGAS10750_RS06660	COG4470	Protein conserved in bacteria
MGAS10750_RS06665	COG1609	Transcriptional regulator
MGAS10750_RS06670	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS10750_RS06680	COG0742	ribosomal rna small subunit methyltransferase
MGAS10750_RS06690	COG0549	Belongs to the carbamate kinase family
MGAS10750_RS06695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS10750_RS06700	COG1288	antiporter activity
MGAS10750_RS06710	COG0454	-acetyltransferase
MGAS10750_RS06715	COG2235	arginine
MGAS10750_RS06740	COG2972	Histidine kinase
MGAS10750_RS06755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS10750_RS06760	COG0785	Cytochrome C biogenesis protein
MGAS10750_RS06765	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS10750_RS06770	COG1518	maintenance of DNA repeat elements
MGAS10750_RS06830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS10750_RS06830	COG1605	Chorismate mutase
MGAS10750_RS06850	COG2226	methyltransferase
MGAS10750_RS06860	COG3250	beta-galactosidase activity
MGAS10750_RS06865	COG2207	Transcriptional regulator
MGAS10750_RS06865	COG4753	response regulator
MGAS10750_RS06870	COG2972	Histidine kinase
MGAS10750_RS06880	COG1653	transport
MGAS10750_RS06885	COG0395	ABC-type sugar transport system, permease component
MGAS10750_RS06890	COG1175	transmembrane transport
MGAS10750_RS06895	COG1940	carbohydrate kinase activity
MGAS10750_RS06900	COG2723	6-phospho-beta-galactosidase activity
MGAS10750_RS06905	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS10750_RS06920	COG0383	alpha-mannosidase activity
MGAS10750_RS07015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS10750_RS07020	COG1739	Uncharacterized protein family UPF0029
MGAS10750_RS07030	COG1098	S1 RNA binding domain
MGAS10750_RS07040	COG2197	response regulator
MGAS10750_RS07045	COG4585	Histidine kinase
MGAS10750_RS07055	COG2815	serine threonine protein kinase
MGAS10750_RS07055	COG0515	serine threonine protein kinase
MGAS10750_RS07065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS10750_RS07065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS10750_RS07075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS10750_RS07095	COG0583	DNA-binding transcription factor activity
MGAS10750_RS07100	COG0183	Belongs to the thiolase family
MGAS10750_RS07105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS10750_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10750_RS07120	COG2610	gluconate transmembrane transporter activity
MGAS10750_RS07135	COG0116	Belongs to the methyltransferase superfamily
MGAS10750_RS07155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS10750_RS07160	COG3579	cysteine-type endopeptidase activity
MGAS10750_RS07170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS10750_RS07175	COG1113	amino acid transport
MGAS10750_RS07180	COG0492	ferredoxin-NADP+ reductase activity
MGAS10750_RS07190	COG1126	abc transporter atp-binding protein
MGAS10750_RS07200	COG0513	Belongs to the DEAD box helicase family
MGAS10750_RS07210	COG0768	penicillin binding
MGAS10750_RS07250	COG1131	(ABC) transporter
MGAS10750_RS07280	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS10750_RS07285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS10750_RS07320	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS10750_RS07325	COG0656	L-ascorbic acid biosynthetic process
MGAS10750_RS07335	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS10750_RS07355	COG0561	phosphatase activity
MGAS10750_RS07360	COG2860	membrane
MGAS10750_RS07370	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS10750_RS07410	COG2217	Heavy metal translocating P-type atpase
MGAS10750_RS07440	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS10750_RS07445	COG0195	Participates in both transcription termination and antitermination
MGAS10750_RS07470	COG4473	ABC transporter
MGAS10750_RS07475	COG1131	(ABC) transporter
MGAS10750_RS07480	COG0537	adenosine 5'-monophosphoramidase activity
MGAS10750_RS07490	COG1316	TRANSCRIPTIONal
MGAS10750_RS07500	COG0802	atpase or kinase
MGAS10750_RS07505	COG2252	PERMEase
MGAS10750_RS07510	COG0561	phosphatase activity
MGAS10750_RS07520	COG3715	PTS system
MGAS10750_RS07525	COG3716	PTS system mannose fructose sorbose family IID component
MGAS10750_RS07550	COG0439	Biotin carboxylase
MGAS10750_RS07565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS10750_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS10750_RS07575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS10750_RS07600	COG1024	Enoyl-CoA hydratase
MGAS10750_RS07605	COG0484	heat shock protein binding
MGAS10750_RS07635	COG0588	phosphoglycerate mutase activity
MGAS10750_RS07640	COG2261	transglycosylase associated protein
MGAS10750_RS07665	COG1335	isochorismatase
MGAS10750_RS07675	COG0436	Aminotransferase
MGAS10750_RS07685	COG0561	phosphatase activity
MGAS10750_RS07690	COG0252	asparaginase activity
MGAS10750_RS07705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS10750_RS07710	COG1129	ABC transporter
MGAS10750_RS07725	COG1132	(ABC) transporter
MGAS10750_RS07730	COG4988	ABC transporter
MGAS10750_RS07735	COG1120	ATPase activity
MGAS10750_RS07760	COG3942	CHAP domain
MGAS10750_RS07760	COG1388	LysM domain
MGAS10750_RS07790	COG1482	cell wall glycoprotein biosynthetic process
MGAS10750_RS07795	COG1940	carbohydrate kinase activity
MGAS10750_RS07805	COG1263	PTS System
MGAS10750_RS07805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10750_RS07805	COG2190	(PTS) system
MGAS10750_RS07810	COG1621	beta-fructofuranosidase activity
MGAS10750_RS07815	COG1609	Transcriptional regulator
MGAS10750_RS07835	COG2131	deaminase
MGAS10750_RS07840	COG0006	proline dipeptidase activity
MGAS10750_RS07880	COG1194	a g-specific adenine glycosylase
MGAS10750_RS07885	COG3620	sequence-specific DNA binding
MGAS10750_RS07890	COG3118	belongs to the thioredoxin family
MGAS10750_RS07920	COG0681	Belongs to the peptidase S26 family
MGAS10750_RS07925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS10750_RS07940	COG1882	Formate acetyltransferase
MGAS10750_RS07945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS10750_RS07960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS10750_RS07965	COG2814	Major facilitator Superfamily
MGAS10750_RS07970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS10750_RS07995	COG0789	Transcriptional regulator
MGAS10750_RS08010	COG2081	HI0933 family
MGAS10750_RS08020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS10750_RS08025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS10750_RS08045	COG0456	acetyltransferase
MGAS10750_RS08050	COG1214	PFAM Peptidase M22, glycoprotease
MGAS10750_RS08065	COG0174	glutamine synthetase
MGAS10750_RS08070	COG0789	Transcriptional regulator
MGAS10750_RS08085	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS10750_RS08140	COG0668	transmembrane transport
MGAS10750_RS08150	COG4720	Psort location CytoplasmicMembrane, score
MGAS10750_RS08155	COG0351	phosphomethylpyrimidine kinase
MGAS10750_RS08200	COG1929	Belongs to the glycerate kinase type-1 family
MGAS10750_RS08205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS10750_RS08225	COG1484	DNA-dependent DNA replication
MGAS10750_RS08320	COG1309	transcriptional regulator
MGAS10750_RS08325	COG1131	(ABC) transporter
MGAS10750_RS08365	COG3843	relaxase mobilization nuclease domain protein
MGAS10750_RS08440	COG0577	efflux transmembrane transporter activity
MGAS10750_RS08445	COG1136	(ABC) transporter
MGAS10750_RS08450	COG2274	protein secretion by the type I secretion system
MGAS10750_RS08470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10750_RS08470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10750_RS08475	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS10750_RS08520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS10750_RS08525	COG1476	TRANSCRIPTIONal
MGAS10750_RS08545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS10750_RS08555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS10750_RS08575	COG1045	serine acetyltransferase
MGAS10750_RS08590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS10750_RS08605	COG3711	transcriptional antiterminator
MGAS10750_RS08625	COG0431	NADPH-dependent FMN reductase
MGAS10750_RS08630	COG1846	Transcriptional regulator
MGAS10750_RS08660	COG1862	Preprotein translocase
MGAS10750_RS08670	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS10750_RS08680	COG3842	ATPase activity
MGAS10750_RS08720	COG2190	(PTS) system
MGAS10750_RS08720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10750_RS08720	COG1263	PTS System
MGAS10750_RS08725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS10750_RS08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS10750_RS08750	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS10750_RS08755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS10750_RS08790	COG0601	transmembrane transport
MGAS10750_RS08800	COG1122	ATPase activity
MGAS10750_RS08820	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS10750_RS08850	COG3711	transcriptional antiterminator
MGAS10750_RS08860	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS10750_RS08860	COG3942	CHAP domain
MGAS10750_RS08865	COG2205	protein histidine kinase activity
MGAS10750_RS08870	COG0745	RESPONSE REGULATOR receiver
MGAS10750_RS08875	COG0577	efflux transmembrane transporter activity
MGAS10750_RS08880	COG1136	(ABC) transporter
MGAS10750_RS08940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS10750_RS08955	COG1882	Formate acetyltransferase
MGAS10750_RS08960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10750_RS08965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS10750_RS08970	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS10750_RS08975	COG2390	Transcriptional regulator
MGAS10750_RS08980	COG1349	DNA-binding transcription factor activity
MGAS10750_RS08985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS10750_RS09000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS10750_RS09015	COG0564	pseudouridine synthase activity
MGAS10750_RS09050	COG0542	response to heat
MGAS10750_RS09055	COG4463	regulation of RNA biosynthetic process
MGAS10750_RS09070	COG0450	alkyl hydroperoxide reductase
MGAS10750_RS09085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS10750_RS09095	COG3404	Formiminotransferase-cyclodeaminase
MGAS10750_RS09110	COG0531	amino acid
MGAS10750_RS09140	COG3590	peptidase
MGAS10750_RS09145	COG0366	Alpha amylase catalytic
MGAS10750_RS09150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS10750_RS09150	COG1263	PTS System
MGAS10750_RS09155	COG2188	Transcriptional regulator
MGAS10750_RS09160	COG1733	regulation of RNA biosynthetic process
MGAS10750_RS09165	COG2514	catechol 2,3-dioxygenase activity
MGAS10750_RS09175	COG0602	queuosine metabolic process
MGAS10750_RS09190	COG1328	CTP reductase activity
MGAS10750_RS09215	COG1393	Belongs to the ArsC family
MGAS10750_RS09230	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS10750_RS09250	COG0582	viral genome integration into host DNA
MGAS10750_RS09260	COG1396	sequence-specific DNA binding
MGAS10750_RS09265	COG3617	BRO family, N-terminal domain
MGAS10750_RS09395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10750_RS09400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10750_RS09405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10750_RS09490	COG1511	domain protein
MGAS10750_RS09510	COG0305	Participates in initiation and elongation during chromosome replication
MGAS10750_RS09540	COG1760	l-serine dehydratase
MGAS10750_RS09545	COG1760	l-serine dehydratase
MGAS10750_RS09550	COG0741	lytic transglycosylase activity
MGAS10750_RS09555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS10750_RS09570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS10750_RS09580	COG0612	Peptidase, M16
MGAS10750_RS09605	COG0516	GMP reductase activity
MGAS10750_RS09605	COG0517	IMP dehydrogenase activity
MGAS10750_RS09615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS10750_RS09620	COG0488	(ABC) transporter
MGAS10750_RS09655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS10750_RS09660	COG1475	DNA binding