locus-tag	class	description
MGAS11027_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS11027_RS00020	COG0012	GTP binding
MGAS11027_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS11027_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS11027_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS11027_RS00065	COG0531	amino acid
MGAS11027_RS00175	COG3942	CHAP domain
MGAS11027_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS11027_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS11027_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS11027_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS11027_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS11027_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS11027_RS00285	COG1454	alcohol dehydrogenase
MGAS11027_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
MGAS11027_RS00290	COG1064	alcohol dehydrogenase
MGAS11027_RS00295	COG0534	Mate efflux family protein
MGAS11027_RS00405	COG0201	protein transport
MGAS11027_RS00545	COG1121	(ABC) transporter
MGAS11027_RS00550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS11027_RS00565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS11027_RS00585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS11027_RS00590	COG1459	type II secretion system
MGAS11027_RS00635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS11027_RS00640	COG1363	Peptidase, m42
MGAS11027_RS00650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS11027_RS00655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS11027_RS00665	COG1428	Deoxynucleoside kinase
MGAS11027_RS00670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS11027_RS00710	COG4509	Sortase family
MGAS11027_RS00755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS11027_RS00770	COG0251	oxidation-reduction process
MGAS11027_RS00785	COG1269	ATP hydrolysis coupled proton transport
MGAS11027_RS00790	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS11027_RS00800	COG1527	subunit (C
MGAS11027_RS00805	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS11027_RS00840	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS11027_RS00880	COG0626	cystathionine gamma-synthase activity
MGAS11027_RS00910	COG3623	hexulose-6-phosphate isomerase
MGAS11027_RS00930	COG4175	Glycine betaine
MGAS11027_RS00930	COG3448	diguanylate cyclase activity
MGAS11027_RS00940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS11027_RS00940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS11027_RS00960	COG3969	phosphoadenosine phosphosulfate
MGAS11027_RS00965	COG1475	DNA binding
MGAS11027_RS00975	COG2801	Transposase and inactivated derivatives
MGAS11027_RS00980	COG2801	Transposase and inactivated derivatives
MGAS11027_RS00995	COG0157	Belongs to the NadC ModD family
MGAS11027_RS01000	COG2801	Transposase and inactivated derivatives
MGAS11027_RS01020	COG1268	BioY protein
MGAS11027_RS01025	COG1234	tRNA 3'-trailer cleavage
MGAS11027_RS01060	COG0457	Tetratricopeptide repeat
MGAS11027_RS01060	COG0705	Rhomboid family
MGAS11027_RS01080	COG1132	(ABC) transporter
MGAS11027_RS01085	COG1132	(ABC) transporter
MGAS11027_RS01095	COG0756	dUTP diphosphatase activity
MGAS11027_RS01125	COG3290	protein histidine kinase activity
MGAS11027_RS01150	COG1847	R3H domain protein
MGAS11027_RS01170	COG1175	transmembrane transport
MGAS11027_RS01175	COG0395	ABC-type sugar transport system, permease component
MGAS11027_RS01190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS11027_RS01205	COG0084	hydrolase, TatD family'
MGAS11027_RS01230	COG1564	THIamine pyrophosphokinase
MGAS11027_RS01245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS11027_RS01270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MGAS11027_RS01280	COG0765	amino acid transport
MGAS11027_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS11027_RS01310	COG0719	Fe-S assembly protein
MGAS11027_RS01315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS11027_RS01330	COG1686	Belongs to the peptidase S11 family
MGAS11027_RS01335	COG1686	Belongs to the peptidase S11 family
MGAS11027_RS01340	COG4166	transmembrane transport
MGAS11027_RS01345	COG0601	transmembrane transport
MGAS11027_RS01350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS11027_RS01355	COG0444	Belongs to the ABC transporter superfamily
MGAS11027_RS01405	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS11027_RS01410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS11027_RS01415	COG1534	Rna-binding protein
MGAS11027_RS01425	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS11027_RS01430	COG0799	negative regulation of ribosome biogenesis
MGAS11027_RS01435	COG2226	methyltransferase
MGAS11027_RS01450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS11027_RS01455	COG1464	Belongs to the NlpA lipoprotein family
MGAS11027_RS01470	COG1114	Component of the transport system for branched-chain amino acids
MGAS11027_RS01480	COG0569	domain protein
MGAS11027_RS01485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS11027_RS01495	COG1704	LemA family
MGAS11027_RS01510	COG0745	RESPONSE REGULATOR receiver
MGAS11027_RS01530	COG1484	DNA-dependent DNA replication
MGAS11027_RS01540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS11027_RS01560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS11027_RS01575	COG1254	Belongs to the acylphosphatase family
MGAS11027_RS01580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS11027_RS01635	COG1187	pseudouridine synthase activity
MGAS11027_RS01650	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS11027_RS01655	COG0671	phosphoesterase, PA-phosphatase related
MGAS11027_RS01660	COG1242	4 iron, 4 sulfur cluster binding
MGAS11027_RS01665	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS11027_RS01670	COG1253	flavin adenine dinucleotide binding
MGAS11027_RS01675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS11027_RS01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS11027_RS01695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS11027_RS01700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS11027_RS01705	COG1120	ATPase activity
MGAS11027_RS01715	COG2244	polysaccharide biosynthetic process
MGAS11027_RS01740	COG0470	DNA polymerase III
MGAS11027_RS01765	COG1393	Belongs to the ArsC family
MGAS11027_RS01770	COG0708	Exodeoxyribonuclease III
MGAS11027_RS01780	COG1304	FMN binding
MGAS11027_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS11027_RS01880	COG0673	inositol 2-dehydrogenase activity
MGAS11027_RS01895	COG0494	nUDIX hydrolase
MGAS11027_RS01905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS11027_RS01950	COG5433	transposase activity
MGAS11027_RS02005	COG1702	phosphate starvation-inducible protein PhoH
MGAS11027_RS02010	COG1573	uracil-dna glycosylase
MGAS11027_RS02020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS11027_RS02045	COG3328	transposase activity
MGAS11027_RS02050	COG3328	transposase activity
MGAS11027_RS02105	COG0433	COG0433 Predicted ATPase
MGAS11027_RS02110	COG2814	Major facilitator Superfamily
MGAS11027_RS02120	COG0557	exoribonuclease II activity
MGAS11027_RS02150	COG0463	Glycosyl transferase, family 2
MGAS11027_RS02160	COG0778	Nitroreductase
MGAS11027_RS02165	COG0006	proline dipeptidase activity
MGAS11027_RS02170	COG1609	Transcriptional regulator
MGAS11027_RS02180	COG0438	transferase activity, transferring glycosyl groups
MGAS11027_RS02190	COG4555	ABC transporter
MGAS11027_RS02210	COG0183	Belongs to the thiolase family
MGAS11027_RS02225	COG0745	RESPONSE REGULATOR receiver
MGAS11027_RS02230	COG5002	protein histidine kinase activity
MGAS11027_RS02235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS11027_RS02245	COG1196	nuclear chromosome segregation
MGAS11027_RS02255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS11027_RS02340	COG4695	Portal protein
MGAS11027_RS02350	COG0561	phosphatase activity
MGAS11027_RS02355	COG0561	phosphatase activity
MGAS11027_RS02360	COG0552	protein localization to endoplasmic reticulum
MGAS11027_RS02365	COG0477	Major facilitator Superfamily
MGAS11027_RS02370	COG3711	transcriptional antiterminator
MGAS11027_RS02375	COG1263	PTS System
MGAS11027_RS02375	COG2190	(PTS) system
MGAS11027_RS02375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS11027_RS02385	COG3689	TIGRFAM TIGR03943 family protein
MGAS11027_RS02390	COG0701	Predicted permease
MGAS11027_RS02395	COG2183	response to ionizing radiation
MGAS11027_RS02440	COG0826	peptidase U32
MGAS11027_RS02445	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS11027_RS02490	COG0386	Belongs to the glutathione peroxidase family
MGAS11027_RS02495	COG1164	Oligoendopeptidase f
MGAS11027_RS02505	COG0772	Belongs to the SEDS family
MGAS11027_RS02540	COG1078	dGTPase activity
MGAS11027_RS02555	COG1609	Transcriptional regulator
MGAS11027_RS02565	COG3716	PTS system mannose fructose sorbose family IID component
MGAS11027_RS02570	COG3715	PTS system
MGAS11027_RS02575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS11027_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS11027_RS02610	COG0546	phosphoglycolate phosphatase activity
MGAS11027_RS02615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS11027_RS02625	COG2884	Cell division ATP-binding protein ftsE
MGAS11027_RS02630	COG2177	Part of the ABC transporter FtsEX involved in
MGAS11027_RS02645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS11027_RS02645	COG1199	ATP-dependent helicase activity
MGAS11027_RS02650	COG0436	Aminotransferase
MGAS11027_RS02770	COG1475	DNA binding
MGAS11027_RS02895	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS11027_RS02920	COG2188	Transcriptional regulator
MGAS11027_RS02925	COG2222	sugar isomerase
MGAS11027_RS02935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS11027_RS02940	COG0716	FMN binding
MGAS11027_RS02950	COG0038	chloride channel
MGAS11027_RS02965	COG0582	viral genome integration into host DNA
MGAS11027_RS03080	COG1475	DNA binding
MGAS11027_RS03205	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS11027_RS03275	COG1131	(ABC) transporter
MGAS11027_RS03295	COG4708	membrane
MGAS11027_RS03305	COG1597	lipid kinase activity
MGAS11027_RS03390	COG0577	efflux transmembrane transporter activity
MGAS11027_RS03395	COG1136	(ABC) transporter
MGAS11027_RS03400	COG2321	neutral zinc metallopeptidase
MGAS11027_RS03425	COG1970	mechanosensitive ion channel activity
MGAS11027_RS03430	COG0358	DNA primase activity
MGAS11027_RS03435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS11027_RS03440	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS11027_RS03485	COG1216	Glycosyl transferase, family 2
MGAS11027_RS03540	COG1368	sulfuric ester hydrolase activity
MGAS11027_RS03545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS11027_RS03565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS11027_RS03570	COG0285	dihydrofolate synthase activity
MGAS11027_RS03580	COG1104	cysteine desulfurase activity
MGAS11027_RS03605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS11027_RS03610	COG0583	DNA-binding transcription factor activity
MGAS11027_RS03620	COG0564	pseudouridine synthase activity
MGAS11027_RS03650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS11027_RS03655	COG1136	(ABC) transporter
MGAS11027_RS03660	COG0577	efflux transmembrane transporter activity
MGAS11027_RS03665	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS11027_RS03675	COG1837	Belongs to the UPF0109 family
MGAS11027_RS03725	COG1349	DNA-binding transcription factor activity
MGAS11027_RS03730	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS11027_RS03735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS11027_RS03735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS11027_RS03735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS11027_RS03740	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS11027_RS03740	COG1388	LysM domain
MGAS11027_RS03745	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS11027_RS03745	COG1388	LysM domain
MGAS11027_RS03765	COG0105	UTP biosynthetic process
MGAS11027_RS03785	COG0488	(ABC) transporter
MGAS11027_RS03795	COG0242	peptide deformylase activity
MGAS11027_RS03805	COG2357	RelA SpoT domain protein
MGAS11027_RS03810	COG0745	RESPONSE REGULATOR receiver
MGAS11027_RS03845	COG3425	synthase
MGAS11027_RS03855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS11027_RS03910	COG0583	DNA-binding transcription factor activity
MGAS11027_RS03935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS11027_RS03940	COG0765	amino acid transport
MGAS11027_RS03960	COG0187	DNA topoisomerase II activity
MGAS11027_RS03970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS11027_RS03990	COG0539	negative regulation of cytoplasmic translation
MGAS11027_RS04025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS11027_RS04030	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS11027_RS04040	COG0300	oxidoreductase activity
MGAS11027_RS04045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS11027_RS04045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS11027_RS04060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS11027_RS04065	COG2384	SAM-dependent methyltransferase
MGAS11027_RS04075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS11027_RS04080	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS11027_RS04090	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS11027_RS04095	COG1051	belongs to the nudix hydrolase family
MGAS11027_RS04100	COG0628	permease
MGAS11027_RS04105	COG0457	Tetratricopeptide repeat
MGAS11027_RS04110	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS11027_RS04145	COG0488	(ABC) transporter
MGAS11027_RS04150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS11027_RS04155	COG0022	dehydrogenase e1 component
MGAS11027_RS04155	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS11027_RS04160	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS11027_RS04180	COG0095	Lipoate-protein ligase
MGAS11027_RS04185	COG3442	glutamine amidotransferase
MGAS11027_RS04190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS11027_RS04195	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS11027_RS04215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS11027_RS04225	COG0647	UMP catabolic process
MGAS11027_RS04240	COG1518	maintenance of DNA repeat elements
MGAS11027_RS04245	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS11027_RS04260	COG0105	UTP biosynthetic process
MGAS11027_RS04295	COG3715	PTS system
MGAS11027_RS04300	COG3716	PTS system mannose fructose sorbose family IID component
MGAS11027_RS04305	COG2972	Histidine kinase
MGAS11027_RS04310	COG4753	response regulator
MGAS11027_RS04310	COG2207	Transcriptional regulator
MGAS11027_RS04320	COG1012	belongs to the aldehyde dehydrogenase family
MGAS11027_RS04335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS11027_RS04415	COG1131	(ABC) transporter
MGAS11027_RS04430	COG1396	sequence-specific DNA binding
MGAS11027_RS04470	COG0285	dihydrofolate synthase activity
MGAS11027_RS04505	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS11027_RS04510	COG1177	transmembrane transport
MGAS11027_RS04520	COG4565	transcriptional regulatory protein
MGAS11027_RS04525	COG3290	protein histidine kinase activity
MGAS11027_RS04530	COG0281	malic enzyme
MGAS11027_RS04540	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS11027_RS04545	COG0038	chloride channel
MGAS11027_RS04555	COG0628	permease
MGAS11027_RS04565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS11027_RS04580	COG1104	cysteine desulfurase activity
MGAS11027_RS04595	COG2357	RelA SpoT domain protein
MGAS11027_RS04605	COG0564	pseudouridine synthase activity
MGAS11027_RS04610	COG0280	phosphate acetyltransferase
MGAS11027_RS04615	COG4221	oxidoreductase activity
MGAS11027_RS04630	COG1174	glycine betaine transport
MGAS11027_RS04645	COG2233	PERMEase
MGAS11027_RS04670	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS11027_RS04700	COG1132	(ABC) transporter
MGAS11027_RS04705	COG1132	(ABC) transporter
MGAS11027_RS04725	COG3764	Sortase (surface protein transpeptidase)
MGAS11027_RS04730	COG0346	lactoylglutathione lyase activity
MGAS11027_RS04745	COG1272	protein, Hemolysin III
MGAS11027_RS04765	COG0758	DNA mediated transformation
MGAS11027_RS04770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS11027_RS04815	COG0511	ligase activity, forming carbon-carbon bonds
MGAS11027_RS04820	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS11027_RS04850	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS11027_RS04870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS11027_RS04880	COG2188	Transcriptional regulator
MGAS11027_RS04900	COG0488	(ABC) transporter
MGAS11027_RS04910	COG0352	thiamine-phosphate diphosphorylase activity
MGAS11027_RS04910	COG0351	phosphomethylpyrimidine kinase
MGAS11027_RS04915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS11027_RS04920	COG1328	CTP reductase activity
MGAS11027_RS04920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS11027_RS04925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS11027_RS04955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS11027_RS04975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS11027_RS04980	COG4684	Psort location CytoplasmicMembrane, score
MGAS11027_RS04985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS11027_RS04990	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS11027_RS04995	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS11027_RS05000	COG3845	ABC transporter
MGAS11027_RS05005	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS11027_RS05010	COG0295	cytidine deaminase activity
MGAS11027_RS05015	COG2813	Specifically methylates the guanine in position
MGAS11027_RS05030	COG5002	protein histidine kinase activity
MGAS11027_RS05035	COG0745	RESPONSE REGULATOR receiver
MGAS11027_RS05045	COG0704	Plays a role in the regulation of phosphate uptake
MGAS11027_RS05060	COG0581	inorganic phosphate transmembrane transporter activity
MGAS11027_RS05065	COG0573	inorganic phosphate transmembrane transporter activity
MGAS11027_RS05075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS11027_RS05075	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS11027_RS05080	COG0483	inositol monophosphate 1-phosphatase activity
MGAS11027_RS05095	COG0196	riboflavin kinase activity
MGAS11027_RS05125	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS11027_RS05125	COG1136	(ABC) transporter
MGAS11027_RS05175	COG1115	amino acid carrier protein
MGAS11027_RS05180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS11027_RS05190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS11027_RS05195	COG1126	abc transporter atp-binding protein
MGAS11027_RS05200	COG0765	amino acid transport
MGAS11027_RS05205	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS11027_RS05220	COG0469	pyruvate kinase activity
MGAS11027_RS05235	COG1725	Transcriptional regulator
MGAS11027_RS05240	COG1131	(ABC) transporter
MGAS11027_RS05265	COG0058	SHG alpha-glucan phosphorylase activity
MGAS11027_RS05270	COG1640	4-alpha-glucanotransferase
MGAS11027_RS05275	COG1609	Transcriptional regulator
MGAS11027_RS05280	COG2182	Extracellular solute-binding protein
MGAS11027_RS05285	COG1175	transmembrane transport
MGAS11027_RS05290	COG3833	ABC-type maltose transport systems, permease component
MGAS11027_RS05305	COG0657	acetylesterase activity
MGAS11027_RS05310	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS11027_RS05320	COG1696	Membrane protein involved in D-alanine export
MGAS11027_RS05340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS11027_RS05345	COG1126	abc transporter atp-binding protein
MGAS11027_RS05350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS11027_RS05360	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS11027_RS05370	COG3711	transcriptional antiterminator
MGAS11027_RS05370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS11027_RS05380	COG2723	6-phospho-beta-galactosidase activity
MGAS11027_RS05400	COG2801	Transposase and inactivated derivatives
MGAS11027_RS05405	COG1187	pseudouridine synthase activity
MGAS11027_RS05415	COG2814	Major facilitator Superfamily
MGAS11027_RS05465	COG4109	DRTGG domain
MGAS11027_RS05495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS11027_RS05495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS11027_RS05500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS11027_RS05505	COG1956	GAF domain-containing protein
MGAS11027_RS05525	COG0513	Belongs to the DEAD box helicase family
MGAS11027_RS05530	COG0726	polysaccharide deacetylase
MGAS11027_RS05550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS11027_RS05555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS11027_RS05560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS11027_RS05580	COG2801	Transposase and inactivated derivatives
MGAS11027_RS05595	COG1476	TRANSCRIPTIONal
MGAS11027_RS05610	COG4122	O-methyltransferase activity
MGAS11027_RS05615	COG2223	nitrite transmembrane transporter activity
MGAS11027_RS05630	COG1187	pseudouridine synthase activity
MGAS11027_RS05675	COG0658	competence protein
MGAS11027_RS05675	COG2333	competence protein COMEC
MGAS11027_RS05680	COG1596	polysaccharide export
MGAS11027_RS05680	COG1555	photosystem II stabilization
MGAS11027_RS05685	COG0204	Acyl-transferase
MGAS11027_RS05690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS11027_RS05705	COG0513	Belongs to the DEAD box helicase family
MGAS11027_RS05720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS11027_RS05735	COG0768	penicillin binding
MGAS11027_RS05740	COG2116	formate transmembrane transporter activity
MGAS11027_RS05750	COG1827	regulation of RNA biosynthetic process
MGAS11027_RS05765	COG2217	Heavy metal translocating P-type atpase
MGAS11027_RS05780	COG2755	lipolytic protein G-D-S-L family
MGAS11027_RS05795	COG0497	DNA recombination
MGAS11027_RS05800	COG1438	arginine binding
MGAS11027_RS05805	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS11027_RS05830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS11027_RS05835	COG0415	Belongs to the DNA photolyase family
MGAS11027_RS05845	COG0765	amino acid transport
MGAS11027_RS05850	COG4703	Protein of unknown function (DUF1797)
MGAS11027_RS05855	COG0542	response to heat
MGAS11027_RS05860	COG0494	nUDIX hydrolase
MGAS11027_RS05875	COG3599	regulation of cell shape
MGAS11027_RS05880	COG2302	S4 RNA-binding domain
MGAS11027_RS05930	COG1217	gtp-binding protein TYPA
MGAS11027_RS05935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS11027_RS05940	COG1940	carbohydrate kinase activity
MGAS11027_RS05950	COG0783	Belongs to the Dps family
MGAS11027_RS05965	COG4470	Protein conserved in bacteria
MGAS11027_RS05970	COG1609	Transcriptional regulator
MGAS11027_RS05975	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS11027_RS05985	COG0742	ribosomal rna small subunit methyltransferase
MGAS11027_RS05995	COG0549	Belongs to the carbamate kinase family
MGAS11027_RS06000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS11027_RS06005	COG1288	antiporter activity
MGAS11027_RS06020	COG2235	arginine
MGAS11027_RS06045	COG2972	Histidine kinase
MGAS11027_RS06060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS11027_RS06065	COG0785	Cytochrome C biogenesis protein
MGAS11027_RS06070	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS11027_RS06135	COG5433	transposase activity
MGAS11027_RS06145	COG1605	Chorismate mutase
MGAS11027_RS06145	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS11027_RS06165	COG2226	methyltransferase
MGAS11027_RS06175	COG3250	beta-galactosidase activity
MGAS11027_RS06180	COG4753	response regulator
MGAS11027_RS06180	COG2207	Transcriptional regulator
MGAS11027_RS06185	COG2972	Histidine kinase
MGAS11027_RS06195	COG1653	transport
MGAS11027_RS06200	COG0395	ABC-type sugar transport system, permease component
MGAS11027_RS06205	COG1175	transmembrane transport
MGAS11027_RS06210	COG1940	carbohydrate kinase activity
MGAS11027_RS06215	COG2723	6-phospho-beta-galactosidase activity
MGAS11027_RS06220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS11027_RS06235	COG0383	alpha-mannosidase activity
MGAS11027_RS06325	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS11027_RS06330	COG1739	Uncharacterized protein family UPF0029
MGAS11027_RS06340	COG1098	S1 RNA binding domain
MGAS11027_RS06350	COG2197	response regulator
MGAS11027_RS06355	COG4585	Histidine kinase
MGAS11027_RS06365	COG2815	serine threonine protein kinase
MGAS11027_RS06365	COG0515	serine threonine protein kinase
MGAS11027_RS06375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS11027_RS06375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS11027_RS06385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS11027_RS06405	COG0583	DNA-binding transcription factor activity
MGAS11027_RS06410	COG0183	Belongs to the thiolase family
MGAS11027_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS11027_RS06430	COG2610	gluconate transmembrane transporter activity
MGAS11027_RS06445	COG0116	Belongs to the methyltransferase superfamily
MGAS11027_RS06470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS11027_RS06475	COG3579	cysteine-type endopeptidase activity
MGAS11027_RS06485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS11027_RS06490	COG1113	amino acid transport
MGAS11027_RS06495	COG0492	ferredoxin-NADP+ reductase activity
MGAS11027_RS06505	COG1126	abc transporter atp-binding protein
MGAS11027_RS06515	COG0513	Belongs to the DEAD box helicase family
MGAS11027_RS06525	COG0768	penicillin binding
MGAS11027_RS06560	COG1131	(ABC) transporter
MGAS11027_RS06585	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS11027_RS06590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS11027_RS06625	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS11027_RS06630	COG0656	L-ascorbic acid biosynthetic process
MGAS11027_RS06640	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS11027_RS06660	COG0561	phosphatase activity
MGAS11027_RS06665	COG2860	membrane
MGAS11027_RS06715	COG2217	Heavy metal translocating P-type atpase
MGAS11027_RS06745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS11027_RS06750	COG0195	Participates in both transcription termination and antitermination
MGAS11027_RS06775	COG4473	ABC transporter
MGAS11027_RS06780	COG1131	(ABC) transporter
MGAS11027_RS06785	COG0537	adenosine 5'-monophosphoramidase activity
MGAS11027_RS06795	COG1316	TRANSCRIPTIONal
MGAS11027_RS06805	COG0802	atpase or kinase
MGAS11027_RS06810	COG2252	PERMEase
MGAS11027_RS06815	COG0561	phosphatase activity
MGAS11027_RS06825	COG3715	PTS system
MGAS11027_RS06830	COG3716	PTS system mannose fructose sorbose family IID component
MGAS11027_RS06855	COG0439	Biotin carboxylase
MGAS11027_RS06870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS11027_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS11027_RS06880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS11027_RS06905	COG1024	Enoyl-CoA hydratase
MGAS11027_RS06940	COG0588	phosphoglycerate mutase activity
MGAS11027_RS06945	COG2261	transglycosylase associated protein
MGAS11027_RS06970	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS11027_RS06970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS11027_RS06975	COG1335	isochorismatase
MGAS11027_RS06985	COG0436	Aminotransferase
MGAS11027_RS06995	COG0561	phosphatase activity
MGAS11027_RS07000	COG0252	asparaginase activity
MGAS11027_RS07015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS11027_RS07020	COG1129	ABC transporter
MGAS11027_RS07035	COG1132	(ABC) transporter
MGAS11027_RS07040	COG4988	ABC transporter
MGAS11027_RS07070	COG3942	CHAP domain
MGAS11027_RS07070	COG1388	LysM domain
MGAS11027_RS07095	COG5433	transposase activity
MGAS11027_RS07100	COG1482	cell wall glycoprotein biosynthetic process
MGAS11027_RS07105	COG1940	carbohydrate kinase activity
MGAS11027_RS07115	COG1263	PTS System
MGAS11027_RS07115	COG2190	(PTS) system
MGAS11027_RS07115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS11027_RS07120	COG1621	beta-fructofuranosidase activity
MGAS11027_RS07125	COG1609	Transcriptional regulator
MGAS11027_RS07145	COG2131	deaminase
MGAS11027_RS07150	COG0006	proline dipeptidase activity
MGAS11027_RS07190	COG1194	a g-specific adenine glycosylase
MGAS11027_RS07195	COG3620	sequence-specific DNA binding
MGAS11027_RS07200	COG3118	belongs to the thioredoxin family
MGAS11027_RS07230	COG0681	Belongs to the peptidase S26 family
MGAS11027_RS07235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS11027_RS07250	COG1882	Formate acetyltransferase
MGAS11027_RS07255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS11027_RS07270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS11027_RS07275	COG2814	Major facilitator Superfamily
MGAS11027_RS07280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS11027_RS07305	COG0789	Transcriptional regulator
MGAS11027_RS07320	COG2081	HI0933 family
MGAS11027_RS07330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS11027_RS07335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS11027_RS07355	COG0456	acetyltransferase
MGAS11027_RS07360	COG1214	PFAM Peptidase M22, glycoprotease
MGAS11027_RS07375	COG0174	glutamine synthetase
MGAS11027_RS07380	COG0789	Transcriptional regulator
MGAS11027_RS07395	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS11027_RS07450	COG0668	transmembrane transport
MGAS11027_RS07460	COG4720	Psort location CytoplasmicMembrane, score
MGAS11027_RS07465	COG0351	phosphomethylpyrimidine kinase
MGAS11027_RS07515	COG5433	transposase activity
MGAS11027_RS07520	COG1929	Belongs to the glycerate kinase type-1 family
MGAS11027_RS07525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS11027_RS07555	COG0577	efflux transmembrane transporter activity
MGAS11027_RS07560	COG1136	(ABC) transporter
MGAS11027_RS07585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS11027_RS07585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS11027_RS07590	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS11027_RS07640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS11027_RS07645	COG1476	TRANSCRIPTIONal
MGAS11027_RS07665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS11027_RS07675	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS11027_RS07695	COG1045	serine acetyltransferase
MGAS11027_RS07710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS11027_RS07755	COG1846	Transcriptional regulator
MGAS11027_RS07775	COG4589	Belongs to the CDS family
MGAS11027_RS07785	COG1862	Preprotein translocase
MGAS11027_RS07795	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS11027_RS07805	COG3842	ATPase activity
MGAS11027_RS07845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS11027_RS07845	COG2190	(PTS) system
MGAS11027_RS07845	COG1263	PTS System
MGAS11027_RS07850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS11027_RS07865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS11027_RS07870	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS11027_RS07875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS11027_RS07915	COG0601	transmembrane transport
MGAS11027_RS07925	COG1122	ATPase activity
MGAS11027_RS07945	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS11027_RS07955	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MGAS11027_RS07955	COG1404	Belongs to the peptidase S8 family
MGAS11027_RS07975	COG3711	transcriptional antiterminator
MGAS11027_RS07985	COG3942	CHAP domain
MGAS11027_RS07985	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS11027_RS07990	COG2205	protein histidine kinase activity
MGAS11027_RS07995	COG0745	RESPONSE REGULATOR receiver
MGAS11027_RS08000	COG0577	efflux transmembrane transporter activity
MGAS11027_RS08005	COG1136	(ABC) transporter
MGAS11027_RS08065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS11027_RS08080	COG1882	Formate acetyltransferase
MGAS11027_RS08085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS11027_RS08090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS11027_RS08095	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS11027_RS08100	COG2390	Transcriptional regulator
MGAS11027_RS08105	COG1349	DNA-binding transcription factor activity
MGAS11027_RS08110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS11027_RS08125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS11027_RS08140	COG0564	pseudouridine synthase activity
MGAS11027_RS08170	COG0542	response to heat
MGAS11027_RS08175	COG4463	regulation of RNA biosynthetic process
MGAS11027_RS08190	COG0450	alkyl hydroperoxide reductase
MGAS11027_RS08205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS11027_RS08215	COG3404	Formiminotransferase-cyclodeaminase
MGAS11027_RS08230	COG0531	amino acid
MGAS11027_RS08260	COG3590	peptidase
MGAS11027_RS08265	COG0366	Alpha amylase catalytic
MGAS11027_RS08270	COG1263	PTS System
MGAS11027_RS08270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS11027_RS08275	COG2188	Transcriptional regulator
MGAS11027_RS08285	COG5433	transposase activity
MGAS11027_RS08290	COG2514	catechol 2,3-dioxygenase activity
MGAS11027_RS08300	COG0602	queuosine metabolic process
MGAS11027_RS08315	COG1328	CTP reductase activity
MGAS11027_RS08340	COG1393	Belongs to the ArsC family
MGAS11027_RS08355	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS11027_RS08400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS11027_RS08405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS11027_RS08410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS11027_RS08495	COG1511	domain protein
MGAS11027_RS08515	COG5433	transposase activity
MGAS11027_RS08525	COG0305	Participates in initiation and elongation during chromosome replication
MGAS11027_RS08555	COG1760	l-serine dehydratase
MGAS11027_RS08560	COG1760	l-serine dehydratase
MGAS11027_RS08565	COG0741	lytic transglycosylase activity
MGAS11027_RS08570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS11027_RS08585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS11027_RS08595	COG0612	Peptidase, M16
MGAS11027_RS08635	COG0516	GMP reductase activity
MGAS11027_RS08635	COG0517	IMP dehydrogenase activity
MGAS11027_RS08645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS11027_RS08650	COG0488	(ABC) transporter
MGAS11027_RS08685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS11027_RS08690	COG1475	DNA binding