locus-tag	class	description
MGAS15252_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS15252_RS00020	COG0012	GTP binding
MGAS15252_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS15252_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS15252_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS15252_RS00065	COG0531	amino acid
MGAS15252_RS00175	COG3942	CHAP domain
MGAS15252_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS15252_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS15252_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS15252_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS15252_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS15252_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS15252_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
MGAS15252_RS00285	COG1454	alcohol dehydrogenase
MGAS15252_RS00290	COG1064	alcohol dehydrogenase
MGAS15252_RS00295	COG0534	Mate efflux family protein
MGAS15252_RS00405	COG0201	protein transport
MGAS15252_RS00520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MGAS15252_RS00540	COG1121	(ABC) transporter
MGAS15252_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS15252_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS15252_RS00560	COG4499	WXG100 protein secretion system (Wss), protein YukC
MGAS15252_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS15252_RS00585	COG1459	type II secretion system
MGAS15252_RS00590	COG4537	Required for transformation and DNA binding
MGAS15252_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS15252_RS00635	COG1363	Peptidase, m42
MGAS15252_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS15252_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS15252_RS00660	COG1428	Deoxynucleoside kinase
MGAS15252_RS00665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS15252_RS00705	COG4509	Sortase family
MGAS15252_RS00730	COG2031	fatty acid transporter
MGAS15252_RS00745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS15252_RS00760	COG0251	oxidation-reduction process
MGAS15252_RS00775	COG1269	ATP hydrolysis coupled proton transport
MGAS15252_RS00780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS15252_RS00790	COG1527	subunit (C
MGAS15252_RS00795	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS15252_RS00830	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS15252_RS00875	COG0626	cystathionine gamma-synthase activity
MGAS15252_RS00905	COG3623	hexulose-6-phosphate isomerase
MGAS15252_RS00925	COG3448	diguanylate cyclase activity
MGAS15252_RS00925	COG4175	Glycine betaine
MGAS15252_RS00935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS15252_RS00935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS15252_RS00955	COG3969	phosphoadenosine phosphosulfate
MGAS15252_RS00960	COG1475	DNA binding
MGAS15252_RS00970	COG2801	Transposase and inactivated derivatives
MGAS15252_RS00975	COG2801	Transposase and inactivated derivatives
MGAS15252_RS00980	COG2801	Transposase and inactivated derivatives
MGAS15252_RS00995	COG0157	Belongs to the NadC ModD family
MGAS15252_RS01000	COG2801	Transposase and inactivated derivatives
MGAS15252_RS01020	COG1268	BioY protein
MGAS15252_RS01025	COG1234	tRNA 3'-trailer cleavage
MGAS15252_RS01055	COG0457	Tetratricopeptide repeat
MGAS15252_RS01055	COG0705	Rhomboid family
MGAS15252_RS01075	COG1132	(ABC) transporter
MGAS15252_RS01080	COG1132	(ABC) transporter
MGAS15252_RS01090	COG0756	dUTP diphosphatase activity
MGAS15252_RS01115	COG3290	protein histidine kinase activity
MGAS15252_RS01140	COG1847	R3H domain protein
MGAS15252_RS01160	COG1175	transmembrane transport
MGAS15252_RS01165	COG0395	ABC-type sugar transport system, permease component
MGAS15252_RS01175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS15252_RS01190	COG0084	hydrolase, TatD family'
MGAS15252_RS01215	COG1564	THIamine pyrophosphokinase
MGAS15252_RS01230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS15252_RS01265	COG0765	amino acid transport
MGAS15252_RS01285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS15252_RS01295	COG0719	Fe-S assembly protein
MGAS15252_RS01300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS15252_RS01315	COG1686	Belongs to the peptidase S11 family
MGAS15252_RS01320	COG1686	Belongs to the peptidase S11 family
MGAS15252_RS01325	COG4166	transmembrane transport
MGAS15252_RS01330	COG0601	transmembrane transport
MGAS15252_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS15252_RS01340	COG0444	Belongs to the ABC transporter superfamily
MGAS15252_RS01390	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS15252_RS01395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS15252_RS01400	COG1534	Rna-binding protein
MGAS15252_RS01410	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS15252_RS01415	COG0799	negative regulation of ribosome biogenesis
MGAS15252_RS01420	COG2226	methyltransferase
MGAS15252_RS01435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS15252_RS01440	COG1464	Belongs to the NlpA lipoprotein family
MGAS15252_RS01455	COG1114	Component of the transport system for branched-chain amino acids
MGAS15252_RS01465	COG0569	domain protein
MGAS15252_RS01470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS15252_RS01480	COG1704	LemA family
MGAS15252_RS01495	COG0745	RESPONSE REGULATOR receiver
MGAS15252_RS01515	COG1484	DNA-dependent DNA replication
MGAS15252_RS01525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS15252_RS01545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS15252_RS01560	COG1254	Belongs to the acylphosphatase family
MGAS15252_RS01565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS15252_RS01620	COG1187	pseudouridine synthase activity
MGAS15252_RS01635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS15252_RS01640	COG0671	phosphoesterase, PA-phosphatase related
MGAS15252_RS01645	COG1242	4 iron, 4 sulfur cluster binding
MGAS15252_RS01650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS15252_RS01655	COG1253	flavin adenine dinucleotide binding
MGAS15252_RS01660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS15252_RS01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS15252_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS15252_RS01685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS15252_RS01690	COG1120	ATPase activity
MGAS15252_RS01700	COG2244	polysaccharide biosynthetic process
MGAS15252_RS01725	COG0470	DNA polymerase III
MGAS15252_RS01760	COG1393	Belongs to the ArsC family
MGAS15252_RS01765	COG0708	Exodeoxyribonuclease III
MGAS15252_RS01775	COG1304	FMN binding
MGAS15252_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS15252_RS01900	COG0673	inositol 2-dehydrogenase activity
MGAS15252_RS01915	COG0494	nUDIX hydrolase
MGAS15252_RS01925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS15252_RS02015	COG1702	phosphate starvation-inducible protein PhoH
MGAS15252_RS02020	COG1573	uracil-dna glycosylase
MGAS15252_RS02030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS15252_RS02125	COG0433	COG0433 Predicted ATPase
MGAS15252_RS02140	COG0557	exoribonuclease II activity
MGAS15252_RS02170	COG0463	Glycosyl transferase, family 2
MGAS15252_RS02180	COG0778	Nitroreductase
MGAS15252_RS02185	COG0006	proline dipeptidase activity
MGAS15252_RS02190	COG1609	Transcriptional regulator
MGAS15252_RS02200	COG0438	transferase activity, transferring glycosyl groups
MGAS15252_RS02210	COG4555	ABC transporter
MGAS15252_RS02230	COG0183	Belongs to the thiolase family
MGAS15252_RS02245	COG0745	RESPONSE REGULATOR receiver
MGAS15252_RS02250	COG5002	protein histidine kinase activity
MGAS15252_RS02255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS15252_RS02265	COG1196	nuclear chromosome segregation
MGAS15252_RS02275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS15252_RS02365	COG4695	Portal protein
MGAS15252_RS02395	COG0124	histidyl-tRNA synthetase
MGAS15252_RS02410	COG0561	phosphatase activity
MGAS15252_RS02415	COG0561	phosphatase activity
MGAS15252_RS02420	COG0552	protein localization to endoplasmic reticulum
MGAS15252_RS02425	COG0477	Major facilitator Superfamily
MGAS15252_RS02430	COG3711	transcriptional antiterminator
MGAS15252_RS02435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS15252_RS02435	COG1263	PTS System
MGAS15252_RS02435	COG2190	(PTS) system
MGAS15252_RS02445	COG3689	TIGRFAM TIGR03943 family protein
MGAS15252_RS02450	COG0701	Predicted permease
MGAS15252_RS02460	COG2183	response to ionizing radiation
MGAS15252_RS02505	COG0826	peptidase U32
MGAS15252_RS02510	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS15252_RS02560	COG0386	Belongs to the glutathione peroxidase family
MGAS15252_RS02565	COG1164	Oligoendopeptidase f
MGAS15252_RS02575	COG0772	Belongs to the SEDS family
MGAS15252_RS02610	COG1078	dGTPase activity
MGAS15252_RS02625	COG1609	Transcriptional regulator
MGAS15252_RS02635	COG3716	PTS system mannose fructose sorbose family IID component
MGAS15252_RS02640	COG3715	PTS system
MGAS15252_RS02645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS15252_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS15252_RS02675	COG0800	Aldolase
MGAS15252_RS02680	COG0546	phosphoglycolate phosphatase activity
MGAS15252_RS02685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS15252_RS02695	COG2884	Cell division ATP-binding protein ftsE
MGAS15252_RS02700	COG2177	Part of the ABC transporter FtsEX involved in
MGAS15252_RS02715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS15252_RS02715	COG1199	ATP-dependent helicase activity
MGAS15252_RS02720	COG0436	Aminotransferase
MGAS15252_RS02755	COG2188	Transcriptional regulator
MGAS15252_RS02760	COG2222	sugar isomerase
MGAS15252_RS02770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS15252_RS02775	COG0716	FMN binding
MGAS15252_RS02785	COG0038	chloride channel
MGAS15252_RS02830	COG5433	transposase activity
MGAS15252_RS02880	COG1131	(ABC) transporter
MGAS15252_RS02900	COG4708	membrane
MGAS15252_RS02910	COG1597	lipid kinase activity
MGAS15252_RS02995	COG0577	efflux transmembrane transporter activity
MGAS15252_RS03005	COG2321	neutral zinc metallopeptidase
MGAS15252_RS03020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS15252_RS03030	COG1970	mechanosensitive ion channel activity
MGAS15252_RS03035	COG0358	DNA primase activity
MGAS15252_RS03040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS15252_RS03045	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS15252_RS03090	COG1216	Glycosyl transferase, family 2
MGAS15252_RS03150	COG1368	sulfuric ester hydrolase activity
MGAS15252_RS03155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS15252_RS03175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS15252_RS03180	COG0285	dihydrofolate synthase activity
MGAS15252_RS03190	COG1104	cysteine desulfurase activity
MGAS15252_RS03215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS15252_RS03220	COG0583	DNA-binding transcription factor activity
MGAS15252_RS03230	COG0564	pseudouridine synthase activity
MGAS15252_RS03260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS15252_RS03265	COG1136	(ABC) transporter
MGAS15252_RS03270	COG0577	efflux transmembrane transporter activity
MGAS15252_RS03275	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS15252_RS03285	COG1837	Belongs to the UPF0109 family
MGAS15252_RS03335	COG1349	DNA-binding transcription factor activity
MGAS15252_RS03340	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS15252_RS03345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS15252_RS03345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS15252_RS03345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS15252_RS03350	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS15252_RS03350	COG1388	LysM domain
MGAS15252_RS03355	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS15252_RS03355	COG1388	LysM domain
MGAS15252_RS03375	COG0105	UTP biosynthetic process
MGAS15252_RS03395	COG0488	(ABC) transporter
MGAS15252_RS03405	COG0242	peptide deformylase activity
MGAS15252_RS03410	COG0737	Belongs to the 5'-nucleotidase family
MGAS15252_RS03415	COG2357	RelA SpoT domain protein
MGAS15252_RS03420	COG0745	RESPONSE REGULATOR receiver
MGAS15252_RS03455	COG3425	synthase
MGAS15252_RS03465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS15252_RS03525	COG0583	DNA-binding transcription factor activity
MGAS15252_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS15252_RS03555	COG0765	amino acid transport
MGAS15252_RS03575	COG0187	DNA topoisomerase II activity
MGAS15252_RS03590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS15252_RS03610	COG0539	negative regulation of cytoplasmic translation
MGAS15252_RS03645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS15252_RS03650	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS15252_RS03660	COG0300	oxidoreductase activity
MGAS15252_RS03665	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS15252_RS03665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS15252_RS03680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS15252_RS03685	COG2384	SAM-dependent methyltransferase
MGAS15252_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS15252_RS03700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS15252_RS03710	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS15252_RS03715	COG1051	belongs to the nudix hydrolase family
MGAS15252_RS03720	COG0628	permease
MGAS15252_RS03725	COG0457	Tetratricopeptide repeat
MGAS15252_RS03730	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS15252_RS03745	COG1129	ABC transporter
MGAS15252_RS03765	COG0488	(ABC) transporter
MGAS15252_RS03770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS15252_RS03775	COG0022	dehydrogenase e1 component
MGAS15252_RS03775	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS15252_RS03780	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS15252_RS03795	COG5492	domain, Protein
MGAS15252_RS03800	COG0095	Lipoate-protein ligase
MGAS15252_RS03805	COG3442	glutamine amidotransferase
MGAS15252_RS03810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS15252_RS03815	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS15252_RS03835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS15252_RS03845	COG0647	UMP catabolic process
MGAS15252_RS03860	COG1518	maintenance of DNA repeat elements
MGAS15252_RS03865	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS15252_RS03880	COG0105	UTP biosynthetic process
MGAS15252_RS03915	COG3715	PTS system
MGAS15252_RS03920	COG3716	PTS system mannose fructose sorbose family IID component
MGAS15252_RS03925	COG2972	Histidine kinase
MGAS15252_RS03930	COG4753	response regulator
MGAS15252_RS03930	COG2207	Transcriptional regulator
MGAS15252_RS03940	COG1012	belongs to the aldehyde dehydrogenase family
MGAS15252_RS03955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS15252_RS03985	COG0285	dihydrofolate synthase activity
MGAS15252_RS04005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS15252_RS04020	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS15252_RS04025	COG1177	transmembrane transport
MGAS15252_RS04035	COG4565	transcriptional regulatory protein
MGAS15252_RS04040	COG3290	protein histidine kinase activity
MGAS15252_RS04045	COG3493	citrate carrier protein
MGAS15252_RS04060	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS15252_RS04065	COG0038	chloride channel
MGAS15252_RS04075	COG0628	permease
MGAS15252_RS04085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS15252_RS04100	COG1104	cysteine desulfurase activity
MGAS15252_RS04115	COG2357	RelA SpoT domain protein
MGAS15252_RS04125	COG0564	pseudouridine synthase activity
MGAS15252_RS04130	COG0280	phosphate acetyltransferase
MGAS15252_RS04135	COG4221	oxidoreductase activity
MGAS15252_RS04150	COG1174	glycine betaine transport
MGAS15252_RS04165	COG2233	PERMEase
MGAS15252_RS04190	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS15252_RS04220	COG1132	(ABC) transporter
MGAS15252_RS04225	COG1132	(ABC) transporter
MGAS15252_RS04245	COG3764	Sortase (surface protein transpeptidase)
MGAS15252_RS04250	COG0346	lactoylglutathione lyase activity
MGAS15252_RS04265	COG1272	protein, Hemolysin III
MGAS15252_RS04285	COG0758	DNA mediated transformation
MGAS15252_RS04290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS15252_RS04335	COG0511	ligase activity, forming carbon-carbon bonds
MGAS15252_RS04340	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS15252_RS04355	COG2851	Citrate transporter
MGAS15252_RS04365	COG0511	ligase activity, forming carbon-carbon bonds
MGAS15252_RS04370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS15252_RS04405	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS15252_RS04425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS15252_RS04435	COG2188	Transcriptional regulator
MGAS15252_RS04455	COG0488	(ABC) transporter
MGAS15252_RS04465	COG0351	phosphomethylpyrimidine kinase
MGAS15252_RS04465	COG0352	thiamine-phosphate diphosphorylase activity
MGAS15252_RS04470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS15252_RS04475	COG1328	CTP reductase activity
MGAS15252_RS04475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS15252_RS04480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS15252_RS04510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS15252_RS04520	COG0095	Lipoate-protein ligase
MGAS15252_RS04530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS15252_RS04535	COG4684	Psort location CytoplasmicMembrane, score
MGAS15252_RS04540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS15252_RS04545	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS15252_RS04550	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS15252_RS04555	COG3845	ABC transporter
MGAS15252_RS04560	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS15252_RS04565	COG0295	cytidine deaminase activity
MGAS15252_RS04570	COG2813	Specifically methylates the guanine in position
MGAS15252_RS04585	COG5002	protein histidine kinase activity
MGAS15252_RS04590	COG0745	RESPONSE REGULATOR receiver
MGAS15252_RS04600	COG0704	Plays a role in the regulation of phosphate uptake
MGAS15252_RS04615	COG0581	inorganic phosphate transmembrane transporter activity
MGAS15252_RS04620	COG0573	inorganic phosphate transmembrane transporter activity
MGAS15252_RS04630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS15252_RS04630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS15252_RS04635	COG0483	inositol monophosphate 1-phosphatase activity
MGAS15252_RS04650	COG0196	riboflavin kinase activity
MGAS15252_RS04680	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS15252_RS04680	COG1136	(ABC) transporter
MGAS15252_RS04730	COG1115	amino acid carrier protein
MGAS15252_RS04735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS15252_RS04745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS15252_RS04750	COG1126	abc transporter atp-binding protein
MGAS15252_RS04755	COG0765	amino acid transport
MGAS15252_RS04760	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS15252_RS04775	COG0246	Mannitol dehydrogenase
MGAS15252_RS04780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS15252_RS04785	COG3711	transcriptional antiterminator
MGAS15252_RS04790	COG2213	PTS system mannitol-specific
MGAS15252_RS04815	COG0469	pyruvate kinase activity
MGAS15252_RS04830	COG1725	Transcriptional regulator
MGAS15252_RS04835	COG1131	(ABC) transporter
MGAS15252_RS04855	COG0058	SHG alpha-glucan phosphorylase activity
MGAS15252_RS04860	COG1640	4-alpha-glucanotransferase
MGAS15252_RS04865	COG1609	Transcriptional regulator
MGAS15252_RS04870	COG2182	Extracellular solute-binding protein
MGAS15252_RS04875	COG1175	transmembrane transport
MGAS15252_RS04880	COG3833	ABC-type maltose transport systems, permease component
MGAS15252_RS04895	COG0657	acetylesterase activity
MGAS15252_RS04900	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS15252_RS04910	COG1696	Membrane protein involved in D-alanine export
MGAS15252_RS04930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS15252_RS04935	COG1126	abc transporter atp-binding protein
MGAS15252_RS04940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS15252_RS04950	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS15252_RS04960	COG3711	transcriptional antiterminator
MGAS15252_RS04960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS15252_RS04970	COG2723	6-phospho-beta-galactosidase activity
MGAS15252_RS05005	COG2801	Transposase and inactivated derivatives
MGAS15252_RS05010	COG1187	pseudouridine synthase activity
MGAS15252_RS05020	COG2814	Major facilitator Superfamily
MGAS15252_RS05070	COG4109	DRTGG domain
MGAS15252_RS05100	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS15252_RS05100	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS15252_RS05105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS15252_RS05110	COG1956	GAF domain-containing protein
MGAS15252_RS05130	COG0513	Belongs to the DEAD box helicase family
MGAS15252_RS05135	COG0726	polysaccharide deacetylase
MGAS15252_RS05155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS15252_RS05160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS15252_RS05180	COG2801	Transposase and inactivated derivatives
MGAS15252_RS05185	COG2801	Transposase and inactivated derivatives
MGAS15252_RS05200	COG1476	TRANSCRIPTIONal
MGAS15252_RS05215	COG4122	O-methyltransferase activity
MGAS15252_RS05220	COG2223	nitrite transmembrane transporter activity
MGAS15252_RS05280	COG0658	competence protein
MGAS15252_RS05280	COG2333	competence protein COMEC
MGAS15252_RS05285	COG1555	photosystem II stabilization
MGAS15252_RS05285	COG1596	polysaccharide export
MGAS15252_RS05290	COG0204	Acyl-transferase
MGAS15252_RS05295	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS15252_RS05310	COG0513	Belongs to the DEAD box helicase family
MGAS15252_RS05325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS15252_RS05340	COG0768	penicillin binding
MGAS15252_RS05345	COG2116	formate transmembrane transporter activity
MGAS15252_RS05355	COG1827	regulation of RNA biosynthetic process
MGAS15252_RS05370	COG2217	Heavy metal translocating P-type atpase
MGAS15252_RS05385	COG2755	lipolytic protein G-D-S-L family
MGAS15252_RS05400	COG0497	DNA recombination
MGAS15252_RS05405	COG1438	arginine binding
MGAS15252_RS05410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS15252_RS05435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS15252_RS05440	COG0415	Belongs to the DNA photolyase family
MGAS15252_RS05450	COG0765	amino acid transport
MGAS15252_RS05455	COG4703	Protein of unknown function (DUF1797)
MGAS15252_RS05460	COG0542	response to heat
MGAS15252_RS05465	COG0494	nUDIX hydrolase
MGAS15252_RS05480	COG3599	regulation of cell shape
MGAS15252_RS05485	COG2302	S4 RNA-binding domain
MGAS15252_RS05500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS15252_RS05535	COG1217	gtp-binding protein TYPA
MGAS15252_RS05540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS15252_RS05545	COG1940	carbohydrate kinase activity
MGAS15252_RS05555	COG0783	Belongs to the Dps family
MGAS15252_RS05570	COG4470	Protein conserved in bacteria
MGAS15252_RS05575	COG1609	Transcriptional regulator
MGAS15252_RS05580	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS15252_RS05590	COG0742	ribosomal rna small subunit methyltransferase
MGAS15252_RS05600	COG0549	Belongs to the carbamate kinase family
MGAS15252_RS05605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS15252_RS05610	COG1288	antiporter activity
MGAS15252_RS05625	COG2235	arginine
MGAS15252_RS05650	COG2972	Histidine kinase
MGAS15252_RS05665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS15252_RS05670	COG0785	Cytochrome C biogenesis protein
MGAS15252_RS05680	COG0673	inositol 2-dehydrogenase activity
MGAS15252_RS05685	COG2801	Transposase and inactivated derivatives
MGAS15252_RS05745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS15252_RS05745	COG1605	Chorismate mutase
MGAS15252_RS05765	COG2226	methyltransferase
MGAS15252_RS05775	COG3250	beta-galactosidase activity
MGAS15252_RS05780	COG2207	Transcriptional regulator
MGAS15252_RS05780	COG4753	response regulator
MGAS15252_RS05785	COG2972	Histidine kinase
MGAS15252_RS05795	COG1653	transport
MGAS15252_RS05800	COG0395	ABC-type sugar transport system, permease component
MGAS15252_RS05805	COG1175	transmembrane transport
MGAS15252_RS05815	COG2723	6-phospho-beta-galactosidase activity
MGAS15252_RS05820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS15252_RS05835	COG0383	alpha-mannosidase activity
MGAS15252_RS05925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS15252_RS05930	COG1739	Uncharacterized protein family UPF0029
MGAS15252_RS05940	COG1098	S1 RNA binding domain
MGAS15252_RS05950	COG2197	response regulator
MGAS15252_RS05955	COG4585	Histidine kinase
MGAS15252_RS05965	COG2815	serine threonine protein kinase
MGAS15252_RS05965	COG0515	serine threonine protein kinase
MGAS15252_RS05975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS15252_RS05975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS15252_RS05985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS15252_RS06010	COG0183	Belongs to the thiolase family
MGAS15252_RS06015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS15252_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS15252_RS06030	COG2610	gluconate transmembrane transporter activity
MGAS15252_RS06045	COG0116	Belongs to the methyltransferase superfamily
MGAS15252_RS06065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS15252_RS06070	COG3579	cysteine-type endopeptidase activity
MGAS15252_RS06080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS15252_RS06085	COG1113	amino acid transport
MGAS15252_RS06090	COG0492	ferredoxin-NADP+ reductase activity
MGAS15252_RS06100	COG1126	abc transporter atp-binding protein
MGAS15252_RS06110	COG0513	Belongs to the DEAD box helicase family
MGAS15252_RS06120	COG0768	penicillin binding
MGAS15252_RS06155	COG1131	(ABC) transporter
MGAS15252_RS06180	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS15252_RS06185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS15252_RS06220	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS15252_RS06225	COG0656	L-ascorbic acid biosynthetic process
MGAS15252_RS06235	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS15252_RS06255	COG0561	phosphatase activity
MGAS15252_RS06260	COG2860	membrane
MGAS15252_RS06310	COG2217	Heavy metal translocating P-type atpase
MGAS15252_RS06340	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS15252_RS06345	COG0195	Participates in both transcription termination and antitermination
MGAS15252_RS06370	COG4473	ABC transporter
MGAS15252_RS06375	COG1131	(ABC) transporter
MGAS15252_RS06380	COG0537	adenosine 5'-monophosphoramidase activity
MGAS15252_RS06390	COG1316	TRANSCRIPTIONal
MGAS15252_RS06400	COG0802	atpase or kinase
MGAS15252_RS06405	COG2252	PERMEase
MGAS15252_RS06410	COG0561	phosphatase activity
MGAS15252_RS06420	COG3715	PTS system
MGAS15252_RS06425	COG3716	PTS system mannose fructose sorbose family IID component
MGAS15252_RS06435	COG5433	transposase activity
MGAS15252_RS06460	COG0439	Biotin carboxylase
MGAS15252_RS06475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS15252_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS15252_RS06485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS15252_RS06510	COG1024	Enoyl-CoA hydratase
MGAS15252_RS06545	COG0588	phosphoglycerate mutase activity
MGAS15252_RS06550	COG2261	transglycosylase associated protein
MGAS15252_RS06575	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS15252_RS06575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS15252_RS06580	COG1335	isochorismatase
MGAS15252_RS06590	COG0436	Aminotransferase
MGAS15252_RS06600	COG0561	phosphatase activity
MGAS15252_RS06605	COG0252	asparaginase activity
MGAS15252_RS06620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS15252_RS06625	COG1129	ABC transporter
MGAS15252_RS06640	COG1132	(ABC) transporter
MGAS15252_RS06645	COG4988	ABC transporter
MGAS15252_RS06650	COG1120	ATPase activity
MGAS15252_RS06675	COG1388	LysM domain
MGAS15252_RS06675	COG3942	CHAP domain
MGAS15252_RS06695	COG1482	cell wall glycoprotein biosynthetic process
MGAS15252_RS06700	COG1940	carbohydrate kinase activity
MGAS15252_RS06710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS15252_RS06710	COG2190	(PTS) system
MGAS15252_RS06710	COG1263	PTS System
MGAS15252_RS06715	COG1621	beta-fructofuranosidase activity
MGAS15252_RS06720	COG1609	Transcriptional regulator
MGAS15252_RS06740	COG2131	deaminase
MGAS15252_RS06745	COG0006	proline dipeptidase activity
MGAS15252_RS06785	COG1194	a g-specific adenine glycosylase
MGAS15252_RS06795	COG3118	belongs to the thioredoxin family
MGAS15252_RS06825	COG0681	Belongs to the peptidase S26 family
MGAS15252_RS06830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS15252_RS06845	COG1882	Formate acetyltransferase
MGAS15252_RS06850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS15252_RS06865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS15252_RS06870	COG2814	Major facilitator Superfamily
MGAS15252_RS06875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS15252_RS06900	COG0789	Transcriptional regulator
MGAS15252_RS06935	COG2081	HI0933 family
MGAS15252_RS06945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS15252_RS06950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS15252_RS06970	COG0456	acetyltransferase
MGAS15252_RS06975	COG1214	PFAM Peptidase M22, glycoprotease
MGAS15252_RS06990	COG0174	glutamine synthetase
MGAS15252_RS06995	COG0789	Transcriptional regulator
MGAS15252_RS07010	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS15252_RS07065	COG0668	transmembrane transport
MGAS15252_RS07075	COG4720	Psort location CytoplasmicMembrane, score
MGAS15252_RS07080	COG0351	phosphomethylpyrimidine kinase
MGAS15252_RS07125	COG1929	Belongs to the glycerate kinase type-1 family
MGAS15252_RS07130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS15252_RS07160	COG0577	efflux transmembrane transporter activity
MGAS15252_RS07165	COG1136	(ABC) transporter
MGAS15252_RS07170	COG1132	(ABC) transporter
MGAS15252_RS07190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS15252_RS07190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS15252_RS07195	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS15252_RS07245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS15252_RS07250	COG1476	TRANSCRIPTIONal
MGAS15252_RS07270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS15252_RS07280	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS15252_RS07295	COG1045	serine acetyltransferase
MGAS15252_RS07310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS15252_RS07325	COG3711	transcriptional antiterminator
MGAS15252_RS07355	COG1846	Transcriptional regulator
MGAS15252_RS07375	COG4589	Belongs to the CDS family
MGAS15252_RS07385	COG1862	Preprotein translocase
MGAS15252_RS07395	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS15252_RS07405	COG3842	ATPase activity
MGAS15252_RS07445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS15252_RS07445	COG1263	PTS System
MGAS15252_RS07445	COG2190	(PTS) system
MGAS15252_RS07450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS15252_RS07465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS15252_RS07470	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS15252_RS07475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS15252_RS07510	COG0601	transmembrane transport
MGAS15252_RS07520	COG1122	ATPase activity
MGAS15252_RS07540	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS15252_RS07550	COG5433	transposase activity
MGAS15252_RS07580	COG3711	transcriptional antiterminator
MGAS15252_RS07590	COG3942	CHAP domain
MGAS15252_RS07590	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS15252_RS07595	COG2205	protein histidine kinase activity
MGAS15252_RS07600	COG0745	RESPONSE REGULATOR receiver
MGAS15252_RS07605	COG0577	efflux transmembrane transporter activity
MGAS15252_RS07610	COG1136	(ABC) transporter
MGAS15252_RS07670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS15252_RS07685	COG1882	Formate acetyltransferase
MGAS15252_RS07690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS15252_RS07695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS15252_RS07700	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS15252_RS07705	COG2390	Transcriptional regulator
MGAS15252_RS07710	COG1349	DNA-binding transcription factor activity
MGAS15252_RS07715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS15252_RS07725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS15252_RS07740	COG0564	pseudouridine synthase activity
MGAS15252_RS07770	COG0542	response to heat
MGAS15252_RS07775	COG4463	regulation of RNA biosynthetic process
MGAS15252_RS07790	COG0450	alkyl hydroperoxide reductase
MGAS15252_RS07805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS15252_RS07815	COG3404	Formiminotransferase-cyclodeaminase
MGAS15252_RS07830	COG0531	amino acid
MGAS15252_RS07860	COG3590	peptidase
MGAS15252_RS07865	COG0366	Alpha amylase catalytic
MGAS15252_RS07870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS15252_RS07870	COG1263	PTS System
MGAS15252_RS07875	COG2188	Transcriptional regulator
MGAS15252_RS07880	COG1733	regulation of RNA biosynthetic process
MGAS15252_RS07885	COG2514	catechol 2,3-dioxygenase activity
MGAS15252_RS07895	COG0602	queuosine metabolic process
MGAS15252_RS07910	COG1328	CTP reductase activity
MGAS15252_RS07935	COG1393	Belongs to the ArsC family
MGAS15252_RS07950	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS15252_RS07960	COG2814	Major facilitator Superfamily
MGAS15252_RS07970	COG0582	viral genome integration into host DNA
MGAS15252_RS08095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS15252_RS08100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS15252_RS08105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS15252_RS08185	COG1511	domain protein
MGAS15252_RS08310	COG0582	viral genome integration into host DNA
MGAS15252_RS08325	COG0305	Participates in initiation and elongation during chromosome replication
MGAS15252_RS08360	COG1760	l-serine dehydratase
MGAS15252_RS08365	COG1760	l-serine dehydratase
MGAS15252_RS08370	COG0741	lytic transglycosylase activity
MGAS15252_RS08375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS15252_RS08390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS15252_RS08400	COG0612	Peptidase, M16
MGAS15252_RS08410	COG1215	transferase activity, transferring glycosyl groups
MGAS15252_RS08420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MGAS15252_RS08440	COG0517	IMP dehydrogenase activity
MGAS15252_RS08440	COG0516	GMP reductase activity
MGAS15252_RS08450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS15252_RS08455	COG0488	(ABC) transporter
MGAS15252_RS08490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS15252_RS08495	COG1475	DNA binding