locus-tag	class	description
MGAS1882_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS1882_RS00020	COG0012	GTP binding
MGAS1882_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS1882_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS1882_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS1882_RS00065	COG0531	amino acid
MGAS1882_RS00175	COG3942	CHAP domain
MGAS1882_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS1882_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS1882_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS1882_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS1882_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS1882_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS1882_RS00285	COG1454	alcohol dehydrogenase
MGAS1882_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
MGAS1882_RS00290	COG1064	alcohol dehydrogenase
MGAS1882_RS00295	COG0534	Mate efflux family protein
MGAS1882_RS00405	COG0201	protein transport
MGAS1882_RS00520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MGAS1882_RS00540	COG1121	(ABC) transporter
MGAS1882_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS1882_RS00560	COG4499	WXG100 protein secretion system (Wss), protein YukC
MGAS1882_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS1882_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS1882_RS00585	COG1459	type II secretion system
MGAS1882_RS00590	COG4537	Required for transformation and DNA binding
MGAS1882_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS1882_RS00635	COG1363	Peptidase, m42
MGAS1882_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS1882_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS1882_RS00660	COG1428	Deoxynucleoside kinase
MGAS1882_RS00665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS1882_RS00705	COG4509	Sortase family
MGAS1882_RS00730	COG2031	fatty acid transporter
MGAS1882_RS00745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS1882_RS00760	COG0251	oxidation-reduction process
MGAS1882_RS00775	COG1269	ATP hydrolysis coupled proton transport
MGAS1882_RS00780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS1882_RS00790	COG1527	subunit (C
MGAS1882_RS00795	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS1882_RS00830	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS1882_RS00875	COG0626	cystathionine gamma-synthase activity
MGAS1882_RS00905	COG3623	hexulose-6-phosphate isomerase
MGAS1882_RS00925	COG3448	diguanylate cyclase activity
MGAS1882_RS00925	COG4175	Glycine betaine
MGAS1882_RS00935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS1882_RS00935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS1882_RS00955	COG3969	phosphoadenosine phosphosulfate
MGAS1882_RS00960	COG1475	DNA binding
MGAS1882_RS00970	COG2801	Transposase and inactivated derivatives
MGAS1882_RS00975	COG2801	Transposase and inactivated derivatives
MGAS1882_RS00980	COG2801	Transposase and inactivated derivatives
MGAS1882_RS00995	COG0157	Belongs to the NadC ModD family
MGAS1882_RS01000	COG2801	Transposase and inactivated derivatives
MGAS1882_RS01020	COG1268	BioY protein
MGAS1882_RS01025	COG1234	tRNA 3'-trailer cleavage
MGAS1882_RS01055	COG0705	Rhomboid family
MGAS1882_RS01055	COG0457	Tetratricopeptide repeat
MGAS1882_RS01075	COG1132	(ABC) transporter
MGAS1882_RS01080	COG1132	(ABC) transporter
MGAS1882_RS01090	COG0756	dUTP diphosphatase activity
MGAS1882_RS01115	COG3290	protein histidine kinase activity
MGAS1882_RS01140	COG1847	R3H domain protein
MGAS1882_RS01160	COG1175	transmembrane transport
MGAS1882_RS01165	COG0395	ABC-type sugar transport system, permease component
MGAS1882_RS01175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS1882_RS01190	COG0084	hydrolase, TatD family'
MGAS1882_RS01215	COG1564	THIamine pyrophosphokinase
MGAS1882_RS01230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS1882_RS01265	COG0765	amino acid transport
MGAS1882_RS01285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS1882_RS01295	COG0719	Fe-S assembly protein
MGAS1882_RS01300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS1882_RS01315	COG1686	Belongs to the peptidase S11 family
MGAS1882_RS01320	COG1686	Belongs to the peptidase S11 family
MGAS1882_RS01325	COG4166	transmembrane transport
MGAS1882_RS01330	COG0601	transmembrane transport
MGAS1882_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS1882_RS01340	COG0444	Belongs to the ABC transporter superfamily
MGAS1882_RS01385	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS1882_RS01390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS1882_RS01395	COG1534	Rna-binding protein
MGAS1882_RS01405	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS1882_RS01410	COG0799	negative regulation of ribosome biogenesis
MGAS1882_RS01415	COG2226	methyltransferase
MGAS1882_RS01430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS1882_RS01435	COG1464	Belongs to the NlpA lipoprotein family
MGAS1882_RS01450	COG1114	Component of the transport system for branched-chain amino acids
MGAS1882_RS01460	COG0569	domain protein
MGAS1882_RS01465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS1882_RS01475	COG1704	LemA family
MGAS1882_RS01490	COG0745	RESPONSE REGULATOR receiver
MGAS1882_RS01510	COG1484	DNA-dependent DNA replication
MGAS1882_RS01520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS1882_RS01540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS1882_RS01555	COG1254	Belongs to the acylphosphatase family
MGAS1882_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS1882_RS01615	COG1187	pseudouridine synthase activity
MGAS1882_RS01630	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS1882_RS01635	COG0671	phosphoesterase, PA-phosphatase related
MGAS1882_RS01640	COG1242	4 iron, 4 sulfur cluster binding
MGAS1882_RS01645	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS1882_RS01650	COG1253	flavin adenine dinucleotide binding
MGAS1882_RS01655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS1882_RS01670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS1882_RS01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS1882_RS01680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS1882_RS01685	COG1120	ATPase activity
MGAS1882_RS01695	COG2244	polysaccharide biosynthetic process
MGAS1882_RS01720	COG0470	DNA polymerase III
MGAS1882_RS01755	COG1393	Belongs to the ArsC family
MGAS1882_RS01760	COG0708	Exodeoxyribonuclease III
MGAS1882_RS01770	COG1304	FMN binding
MGAS1882_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS1882_RS01880	COG0673	inositol 2-dehydrogenase activity
MGAS1882_RS01895	COG0494	nUDIX hydrolase
MGAS1882_RS01905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS1882_RS01995	COG1702	phosphate starvation-inducible protein PhoH
MGAS1882_RS02000	COG1573	uracil-dna glycosylase
MGAS1882_RS02010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS1882_RS02105	COG0433	COG0433 Predicted ATPase
MGAS1882_RS02120	COG0557	exoribonuclease II activity
MGAS1882_RS02150	COG0463	Glycosyl transferase, family 2
MGAS1882_RS02160	COG0778	Nitroreductase
MGAS1882_RS02165	COG0006	proline dipeptidase activity
MGAS1882_RS02170	COG1609	Transcriptional regulator
MGAS1882_RS02180	COG0438	transferase activity, transferring glycosyl groups
MGAS1882_RS02190	COG4555	ABC transporter
MGAS1882_RS02210	COG0183	Belongs to the thiolase family
MGAS1882_RS02225	COG0745	RESPONSE REGULATOR receiver
MGAS1882_RS02230	COG5002	protein histidine kinase activity
MGAS1882_RS02235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS1882_RS02245	COG1196	nuclear chromosome segregation
MGAS1882_RS02255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS1882_RS02345	COG4695	Portal protein
MGAS1882_RS02375	COG0124	histidyl-tRNA synthetase
MGAS1882_RS02390	COG0561	phosphatase activity
MGAS1882_RS02395	COG0561	phosphatase activity
MGAS1882_RS02400	COG0552	protein localization to endoplasmic reticulum
MGAS1882_RS02405	COG0477	Major facilitator Superfamily
MGAS1882_RS02410	COG3711	transcriptional antiterminator
MGAS1882_RS02415	COG2190	(PTS) system
MGAS1882_RS02415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS1882_RS02415	COG1263	PTS System
MGAS1882_RS02425	COG3689	TIGRFAM TIGR03943 family protein
MGAS1882_RS02430	COG0701	Predicted permease
MGAS1882_RS02440	COG2183	response to ionizing radiation
MGAS1882_RS02485	COG0826	peptidase U32
MGAS1882_RS02490	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS1882_RS02540	COG0386	Belongs to the glutathione peroxidase family
MGAS1882_RS02545	COG1164	Oligoendopeptidase f
MGAS1882_RS02555	COG0772	Belongs to the SEDS family
MGAS1882_RS02590	COG1078	dGTPase activity
MGAS1882_RS02605	COG1609	Transcriptional regulator
MGAS1882_RS02615	COG3716	PTS system mannose fructose sorbose family IID component
MGAS1882_RS02620	COG3715	PTS system
MGAS1882_RS02625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS1882_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS1882_RS02655	COG0800	Aldolase
MGAS1882_RS02660	COG0546	phosphoglycolate phosphatase activity
MGAS1882_RS02665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS1882_RS02675	COG2884	Cell division ATP-binding protein ftsE
MGAS1882_RS02680	COG2177	Part of the ABC transporter FtsEX involved in
MGAS1882_RS02695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS1882_RS02695	COG1199	ATP-dependent helicase activity
MGAS1882_RS02700	COG0436	Aminotransferase
MGAS1882_RS02735	COG2188	Transcriptional regulator
MGAS1882_RS02740	COG2222	sugar isomerase
MGAS1882_RS02750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS1882_RS02755	COG0716	FMN binding
MGAS1882_RS02765	COG0038	chloride channel
MGAS1882_RS02860	COG1131	(ABC) transporter
MGAS1882_RS02880	COG4708	membrane
MGAS1882_RS02890	COG1597	lipid kinase activity
MGAS1882_RS02975	COG0577	efflux transmembrane transporter activity
MGAS1882_RS02985	COG2321	neutral zinc metallopeptidase
MGAS1882_RS03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS1882_RS03010	COG1970	mechanosensitive ion channel activity
MGAS1882_RS03015	COG0358	DNA primase activity
MGAS1882_RS03020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS1882_RS03025	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS1882_RS03070	COG1216	Glycosyl transferase, family 2
MGAS1882_RS03130	COG1368	sulfuric ester hydrolase activity
MGAS1882_RS03135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS1882_RS03155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS1882_RS03160	COG0285	dihydrofolate synthase activity
MGAS1882_RS03170	COG1104	cysteine desulfurase activity
MGAS1882_RS03195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS1882_RS03200	COG0583	DNA-binding transcription factor activity
MGAS1882_RS03210	COG0564	pseudouridine synthase activity
MGAS1882_RS03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS1882_RS03245	COG1136	(ABC) transporter
MGAS1882_RS03250	COG0577	efflux transmembrane transporter activity
MGAS1882_RS03255	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS1882_RS03265	COG1837	Belongs to the UPF0109 family
MGAS1882_RS03315	COG1349	DNA-binding transcription factor activity
MGAS1882_RS03320	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS1882_RS03325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS1882_RS03325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS1882_RS03325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS1882_RS03330	COG1388	LysM domain
MGAS1882_RS03330	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS1882_RS03335	COG1388	LysM domain
MGAS1882_RS03335	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS1882_RS03355	COG0105	UTP biosynthetic process
MGAS1882_RS03375	COG0488	(ABC) transporter
MGAS1882_RS03385	COG0242	peptide deformylase activity
MGAS1882_RS03390	COG0737	Belongs to the 5'-nucleotidase family
MGAS1882_RS03395	COG2357	RelA SpoT domain protein
MGAS1882_RS03400	COG0745	RESPONSE REGULATOR receiver
MGAS1882_RS03435	COG3425	synthase
MGAS1882_RS03445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS1882_RS03505	COG0583	DNA-binding transcription factor activity
MGAS1882_RS03530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS1882_RS03535	COG0765	amino acid transport
MGAS1882_RS03555	COG0187	DNA topoisomerase II activity
MGAS1882_RS03570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS1882_RS03590	COG0539	negative regulation of cytoplasmic translation
MGAS1882_RS03625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS1882_RS03630	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS1882_RS03640	COG0300	oxidoreductase activity
MGAS1882_RS03645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS1882_RS03645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS1882_RS03660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS1882_RS03665	COG2384	SAM-dependent methyltransferase
MGAS1882_RS03675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS1882_RS03680	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS1882_RS03690	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS1882_RS03695	COG1051	belongs to the nudix hydrolase family
MGAS1882_RS03700	COG0628	permease
MGAS1882_RS03705	COG0457	Tetratricopeptide repeat
MGAS1882_RS03710	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS1882_RS03725	COG1129	ABC transporter
MGAS1882_RS03745	COG0488	(ABC) transporter
MGAS1882_RS03750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS1882_RS03755	COG0022	dehydrogenase e1 component
MGAS1882_RS03755	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS1882_RS03760	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS1882_RS03775	COG5492	domain, Protein
MGAS1882_RS03780	COG0095	Lipoate-protein ligase
MGAS1882_RS03785	COG3442	glutamine amidotransferase
MGAS1882_RS03790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS1882_RS03795	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS1882_RS03815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS1882_RS03825	COG0647	UMP catabolic process
MGAS1882_RS03840	COG1518	maintenance of DNA repeat elements
MGAS1882_RS03845	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS1882_RS03860	COG0105	UTP biosynthetic process
MGAS1882_RS03895	COG3715	PTS system
MGAS1882_RS03900	COG3716	PTS system mannose fructose sorbose family IID component
MGAS1882_RS03905	COG2972	Histidine kinase
MGAS1882_RS03910	COG2207	Transcriptional regulator
MGAS1882_RS03910	COG4753	response regulator
MGAS1882_RS03920	COG1012	belongs to the aldehyde dehydrogenase family
MGAS1882_RS03935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS1882_RS03965	COG0285	dihydrofolate synthase activity
MGAS1882_RS03985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS1882_RS04000	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS1882_RS04005	COG1177	transmembrane transport
MGAS1882_RS04015	COG4565	transcriptional regulatory protein
MGAS1882_RS04020	COG3290	protein histidine kinase activity
MGAS1882_RS04025	COG3493	citrate carrier protein
MGAS1882_RS04040	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS1882_RS04045	COG0038	chloride channel
MGAS1882_RS04055	COG0628	permease
MGAS1882_RS04065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS1882_RS04080	COG1104	cysteine desulfurase activity
MGAS1882_RS04095	COG2357	RelA SpoT domain protein
MGAS1882_RS04105	COG0564	pseudouridine synthase activity
MGAS1882_RS04110	COG0280	phosphate acetyltransferase
MGAS1882_RS04115	COG4221	oxidoreductase activity
MGAS1882_RS04130	COG1174	glycine betaine transport
MGAS1882_RS04145	COG2233	PERMEase
MGAS1882_RS04170	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS1882_RS04200	COG1132	(ABC) transporter
MGAS1882_RS04205	COG1132	(ABC) transporter
MGAS1882_RS04225	COG3764	Sortase (surface protein transpeptidase)
MGAS1882_RS04230	COG0346	lactoylglutathione lyase activity
MGAS1882_RS04245	COG1272	protein, Hemolysin III
MGAS1882_RS04265	COG0758	DNA mediated transformation
MGAS1882_RS04270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS1882_RS04315	COG0511	ligase activity, forming carbon-carbon bonds
MGAS1882_RS04320	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS1882_RS04335	COG2851	Citrate transporter
MGAS1882_RS04345	COG0511	ligase activity, forming carbon-carbon bonds
MGAS1882_RS04350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS1882_RS04385	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS1882_RS04405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS1882_RS04415	COG2188	Transcriptional regulator
MGAS1882_RS04435	COG0488	(ABC) transporter
MGAS1882_RS04445	COG0352	thiamine-phosphate diphosphorylase activity
MGAS1882_RS04445	COG0351	phosphomethylpyrimidine kinase
MGAS1882_RS04450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS1882_RS04455	COG1328	CTP reductase activity
MGAS1882_RS04455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS1882_RS04460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS1882_RS04490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS1882_RS04500	COG0095	Lipoate-protein ligase
MGAS1882_RS04510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS1882_RS04515	COG4684	Psort location CytoplasmicMembrane, score
MGAS1882_RS04520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS1882_RS04525	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS1882_RS04530	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS1882_RS04535	COG3845	ABC transporter
MGAS1882_RS04540	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS1882_RS04545	COG0295	cytidine deaminase activity
MGAS1882_RS04550	COG2813	Specifically methylates the guanine in position
MGAS1882_RS04565	COG5002	protein histidine kinase activity
MGAS1882_RS04570	COG0745	RESPONSE REGULATOR receiver
MGAS1882_RS04580	COG0704	Plays a role in the regulation of phosphate uptake
MGAS1882_RS04595	COG0581	inorganic phosphate transmembrane transporter activity
MGAS1882_RS04600	COG0573	inorganic phosphate transmembrane transporter activity
MGAS1882_RS04610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS1882_RS04610	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS1882_RS04615	COG0483	inositol monophosphate 1-phosphatase activity
MGAS1882_RS04630	COG0196	riboflavin kinase activity
MGAS1882_RS04660	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS1882_RS04660	COG1136	(ABC) transporter
MGAS1882_RS04710	COG1115	amino acid carrier protein
MGAS1882_RS04715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS1882_RS04725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS1882_RS04730	COG1126	abc transporter atp-binding protein
MGAS1882_RS04735	COG0765	amino acid transport
MGAS1882_RS04740	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS1882_RS04755	COG0246	Mannitol dehydrogenase
MGAS1882_RS04760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS1882_RS04765	COG3711	transcriptional antiterminator
MGAS1882_RS04770	COG2213	PTS system mannitol-specific
MGAS1882_RS04795	COG0469	pyruvate kinase activity
MGAS1882_RS04810	COG1725	Transcriptional regulator
MGAS1882_RS04815	COG1131	(ABC) transporter
MGAS1882_RS04835	COG0058	SHG alpha-glucan phosphorylase activity
MGAS1882_RS04840	COG1640	4-alpha-glucanotransferase
MGAS1882_RS04845	COG1609	Transcriptional regulator
MGAS1882_RS04850	COG2182	Extracellular solute-binding protein
MGAS1882_RS04855	COG1175	transmembrane transport
MGAS1882_RS04860	COG3833	ABC-type maltose transport systems, permease component
MGAS1882_RS04875	COG0657	acetylesterase activity
MGAS1882_RS04880	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS1882_RS04890	COG1696	Membrane protein involved in D-alanine export
MGAS1882_RS04910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS1882_RS04915	COG1126	abc transporter atp-binding protein
MGAS1882_RS04920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS1882_RS04930	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS1882_RS04940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS1882_RS04940	COG3711	transcriptional antiterminator
MGAS1882_RS04950	COG2723	6-phospho-beta-galactosidase activity
MGAS1882_RS04985	COG2801	Transposase and inactivated derivatives
MGAS1882_RS04990	COG1187	pseudouridine synthase activity
MGAS1882_RS05000	COG2814	Major facilitator Superfamily
MGAS1882_RS05050	COG4109	DRTGG domain
MGAS1882_RS05080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS1882_RS05080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS1882_RS05085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS1882_RS05090	COG1956	GAF domain-containing protein
MGAS1882_RS05110	COG0513	Belongs to the DEAD box helicase family
MGAS1882_RS05115	COG0726	polysaccharide deacetylase
MGAS1882_RS05135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS1882_RS05140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS1882_RS05160	COG2801	Transposase and inactivated derivatives
MGAS1882_RS05165	COG2801	Transposase and inactivated derivatives
MGAS1882_RS05180	COG1476	TRANSCRIPTIONal
MGAS1882_RS05195	COG4122	O-methyltransferase activity
MGAS1882_RS05200	COG2223	nitrite transmembrane transporter activity
MGAS1882_RS05215	COG1187	pseudouridine synthase activity
MGAS1882_RS05260	COG0658	competence protein
MGAS1882_RS05260	COG2333	competence protein COMEC
MGAS1882_RS05265	COG1596	polysaccharide export
MGAS1882_RS05265	COG1555	photosystem II stabilization
MGAS1882_RS05270	COG0204	Acyl-transferase
MGAS1882_RS05275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS1882_RS05290	COG0513	Belongs to the DEAD box helicase family
MGAS1882_RS05305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS1882_RS05320	COG0768	penicillin binding
MGAS1882_RS05325	COG2116	formate transmembrane transporter activity
MGAS1882_RS05335	COG1827	regulation of RNA biosynthetic process
MGAS1882_RS05350	COG2217	Heavy metal translocating P-type atpase
MGAS1882_RS05385	COG0860	N-Acetylmuramoyl-L-alanine amidase
MGAS1882_RS05385	COG1388	LysM domain
MGAS1882_RS05660	COG0582	viral genome integration into host DNA
MGAS1882_RS05675	COG2755	lipolytic protein G-D-S-L family
MGAS1882_RS05690	COG0497	DNA recombination
MGAS1882_RS05695	COG1438	arginine binding
MGAS1882_RS05700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS1882_RS05725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS1882_RS05730	COG0415	Belongs to the DNA photolyase family
MGAS1882_RS05740	COG0765	amino acid transport
MGAS1882_RS05745	COG4703	Protein of unknown function (DUF1797)
MGAS1882_RS05750	COG0542	response to heat
MGAS1882_RS05755	COG0494	nUDIX hydrolase
MGAS1882_RS05770	COG3599	regulation of cell shape
MGAS1882_RS05775	COG2302	S4 RNA-binding domain
MGAS1882_RS05790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS1882_RS05825	COG1217	gtp-binding protein TYPA
MGAS1882_RS05830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS1882_RS05835	COG1940	carbohydrate kinase activity
MGAS1882_RS05845	COG0783	Belongs to the Dps family
MGAS1882_RS05860	COG4470	Protein conserved in bacteria
MGAS1882_RS05865	COG1609	Transcriptional regulator
MGAS1882_RS05870	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS1882_RS05880	COG0742	ribosomal rna small subunit methyltransferase
MGAS1882_RS05890	COG0549	Belongs to the carbamate kinase family
MGAS1882_RS05895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS1882_RS05900	COG1288	antiporter activity
MGAS1882_RS05915	COG2235	arginine
MGAS1882_RS05940	COG2972	Histidine kinase
MGAS1882_RS05955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS1882_RS05960	COG0785	Cytochrome C biogenesis protein
MGAS1882_RS05970	COG0673	inositol 2-dehydrogenase activity
MGAS1882_RS05975	COG2801	Transposase and inactivated derivatives
MGAS1882_RS06035	COG1605	Chorismate mutase
MGAS1882_RS06035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS1882_RS06055	COG2226	methyltransferase
MGAS1882_RS06065	COG3250	beta-galactosidase activity
MGAS1882_RS06070	COG4753	response regulator
MGAS1882_RS06070	COG2207	Transcriptional regulator
MGAS1882_RS06075	COG2972	Histidine kinase
MGAS1882_RS06085	COG1653	transport
MGAS1882_RS06090	COG0395	ABC-type sugar transport system, permease component
MGAS1882_RS06095	COG1175	transmembrane transport
MGAS1882_RS06105	COG2723	6-phospho-beta-galactosidase activity
MGAS1882_RS06110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS1882_RS06125	COG0383	alpha-mannosidase activity
MGAS1882_RS06215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS1882_RS06220	COG1739	Uncharacterized protein family UPF0029
MGAS1882_RS06230	COG1098	S1 RNA binding domain
MGAS1882_RS06240	COG2197	response regulator
MGAS1882_RS06245	COG4585	Histidine kinase
MGAS1882_RS06255	COG0515	serine threonine protein kinase
MGAS1882_RS06255	COG2815	serine threonine protein kinase
MGAS1882_RS06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS1882_RS06265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS1882_RS06275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS1882_RS06300	COG0183	Belongs to the thiolase family
MGAS1882_RS06305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS1882_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS1882_RS06320	COG2610	gluconate transmembrane transporter activity
MGAS1882_RS06335	COG0116	Belongs to the methyltransferase superfamily
MGAS1882_RS06355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS1882_RS06360	COG3579	cysteine-type endopeptidase activity
MGAS1882_RS06370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS1882_RS06375	COG1113	amino acid transport
MGAS1882_RS06380	COG0492	ferredoxin-NADP+ reductase activity
MGAS1882_RS06390	COG1126	abc transporter atp-binding protein
MGAS1882_RS06400	COG0513	Belongs to the DEAD box helicase family
MGAS1882_RS06410	COG0768	penicillin binding
MGAS1882_RS06445	COG1131	(ABC) transporter
MGAS1882_RS06475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS1882_RS06510	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS1882_RS06515	COG0656	L-ascorbic acid biosynthetic process
MGAS1882_RS06525	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS1882_RS06545	COG0561	phosphatase activity
MGAS1882_RS06550	COG2860	membrane
MGAS1882_RS06600	COG2217	Heavy metal translocating P-type atpase
MGAS1882_RS06630	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS1882_RS06635	COG0195	Participates in both transcription termination and antitermination
MGAS1882_RS06660	COG4473	ABC transporter
MGAS1882_RS06665	COG1131	(ABC) transporter
MGAS1882_RS06670	COG0537	adenosine 5'-monophosphoramidase activity
MGAS1882_RS06680	COG1316	TRANSCRIPTIONal
MGAS1882_RS06690	COG0802	atpase or kinase
MGAS1882_RS06695	COG2252	PERMEase
MGAS1882_RS06700	COG0561	phosphatase activity
MGAS1882_RS06710	COG3715	PTS system
MGAS1882_RS06715	COG3716	PTS system mannose fructose sorbose family IID component
MGAS1882_RS06725	COG5433	transposase activity
MGAS1882_RS06750	COG0439	Biotin carboxylase
MGAS1882_RS06765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS1882_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS1882_RS06775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS1882_RS06800	COG1024	Enoyl-CoA hydratase
MGAS1882_RS06835	COG0588	phosphoglycerate mutase activity
MGAS1882_RS06840	COG2261	transglycosylase associated protein
MGAS1882_RS06865	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS1882_RS06865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS1882_RS06870	COG1335	isochorismatase
MGAS1882_RS06880	COG0436	Aminotransferase
MGAS1882_RS06890	COG0561	phosphatase activity
MGAS1882_RS06895	COG0252	asparaginase activity
MGAS1882_RS06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS1882_RS06915	COG1129	ABC transporter
MGAS1882_RS06930	COG1132	(ABC) transporter
MGAS1882_RS06935	COG4988	ABC transporter
MGAS1882_RS06940	COG1120	ATPase activity
MGAS1882_RS06965	COG3942	CHAP domain
MGAS1882_RS06965	COG1388	LysM domain
MGAS1882_RS06985	COG1482	cell wall glycoprotein biosynthetic process
MGAS1882_RS06990	COG1940	carbohydrate kinase activity
MGAS1882_RS07000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS1882_RS07000	COG2190	(PTS) system
MGAS1882_RS07000	COG1263	PTS System
MGAS1882_RS07005	COG1621	beta-fructofuranosidase activity
MGAS1882_RS07010	COG1609	Transcriptional regulator
MGAS1882_RS07030	COG2131	deaminase
MGAS1882_RS07035	COG0006	proline dipeptidase activity
MGAS1882_RS07075	COG1194	a g-specific adenine glycosylase
MGAS1882_RS07085	COG3118	belongs to the thioredoxin family
MGAS1882_RS07115	COG0681	Belongs to the peptidase S26 family
MGAS1882_RS07120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS1882_RS07135	COG1882	Formate acetyltransferase
MGAS1882_RS07140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS1882_RS07155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS1882_RS07160	COG2814	Major facilitator Superfamily
MGAS1882_RS07165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS1882_RS07190	COG0789	Transcriptional regulator
MGAS1882_RS07225	COG2081	HI0933 family
MGAS1882_RS07235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS1882_RS07240	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS1882_RS07260	COG0456	acetyltransferase
MGAS1882_RS07265	COG1214	PFAM Peptidase M22, glycoprotease
MGAS1882_RS07280	COG0174	glutamine synthetase
MGAS1882_RS07285	COG0789	Transcriptional regulator
MGAS1882_RS07300	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS1882_RS07355	COG0668	transmembrane transport
MGAS1882_RS07365	COG4720	Psort location CytoplasmicMembrane, score
MGAS1882_RS07370	COG0351	phosphomethylpyrimidine kinase
MGAS1882_RS07415	COG1929	Belongs to the glycerate kinase type-1 family
MGAS1882_RS07420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS1882_RS07450	COG0577	efflux transmembrane transporter activity
MGAS1882_RS07455	COG1136	(ABC) transporter
MGAS1882_RS07460	COG1132	(ABC) transporter
MGAS1882_RS07480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS1882_RS07480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS1882_RS07485	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS1882_RS07530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS1882_RS07535	COG1476	TRANSCRIPTIONal
MGAS1882_RS07555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS1882_RS07565	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS1882_RS07580	COG1045	serine acetyltransferase
MGAS1882_RS07595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS1882_RS07610	COG3711	transcriptional antiterminator
MGAS1882_RS07640	COG1846	Transcriptional regulator
MGAS1882_RS07660	COG4589	Belongs to the CDS family
MGAS1882_RS07670	COG1862	Preprotein translocase
MGAS1882_RS07680	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS1882_RS07690	COG3842	ATPase activity
MGAS1882_RS07730	COG2190	(PTS) system
MGAS1882_RS07730	COG1263	PTS System
MGAS1882_RS07730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS1882_RS07735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS1882_RS07750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS1882_RS07755	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS1882_RS07760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS1882_RS07795	COG0601	transmembrane transport
MGAS1882_RS07805	COG1122	ATPase activity
MGAS1882_RS07825	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS1882_RS07870	COG3711	transcriptional antiterminator
MGAS1882_RS07880	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS1882_RS07880	COG3942	CHAP domain
MGAS1882_RS07885	COG2205	protein histidine kinase activity
MGAS1882_RS07890	COG0745	RESPONSE REGULATOR receiver
MGAS1882_RS07895	COG0577	efflux transmembrane transporter activity
MGAS1882_RS07900	COG1136	(ABC) transporter
MGAS1882_RS07960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS1882_RS07975	COG1882	Formate acetyltransferase
MGAS1882_RS07980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS1882_RS07985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS1882_RS07990	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS1882_RS07995	COG2390	Transcriptional regulator
MGAS1882_RS08000	COG1349	DNA-binding transcription factor activity
MGAS1882_RS08005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS1882_RS08015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS1882_RS08030	COG0564	pseudouridine synthase activity
MGAS1882_RS08060	COG0542	response to heat
MGAS1882_RS08065	COG4463	regulation of RNA biosynthetic process
MGAS1882_RS08080	COG0450	alkyl hydroperoxide reductase
MGAS1882_RS08095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS1882_RS08105	COG3404	Formiminotransferase-cyclodeaminase
MGAS1882_RS08120	COG0531	amino acid
MGAS1882_RS08150	COG3590	peptidase
MGAS1882_RS08155	COG0366	Alpha amylase catalytic
MGAS1882_RS08160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS1882_RS08160	COG1263	PTS System
MGAS1882_RS08165	COG2188	Transcriptional regulator
MGAS1882_RS08170	COG1733	regulation of RNA biosynthetic process
MGAS1882_RS08175	COG2514	catechol 2,3-dioxygenase activity
MGAS1882_RS08185	COG0602	queuosine metabolic process
MGAS1882_RS08200	COG1328	CTP reductase activity
MGAS1882_RS08225	COG1393	Belongs to the ArsC family
MGAS1882_RS08240	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS1882_RS08250	COG2814	Major facilitator Superfamily
MGAS1882_RS08260	COG0582	viral genome integration into host DNA
MGAS1882_RS08385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS1882_RS08390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS1882_RS08395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS1882_RS08475	COG1511	domain protein
MGAS1882_RS08495	COG0305	Participates in initiation and elongation during chromosome replication
MGAS1882_RS08530	COG1760	l-serine dehydratase
MGAS1882_RS08535	COG1760	l-serine dehydratase
MGAS1882_RS08540	COG0741	lytic transglycosylase activity
MGAS1882_RS08545	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS1882_RS08560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS1882_RS08570	COG0612	Peptidase, M16
MGAS1882_RS08580	COG1215	transferase activity, transferring glycosyl groups
MGAS1882_RS08590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MGAS1882_RS08610	COG0516	GMP reductase activity
MGAS1882_RS08610	COG0517	IMP dehydrogenase activity
MGAS1882_RS08620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS1882_RS08625	COG0488	(ABC) transporter
MGAS1882_RS08660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS1882_RS08665	COG1475	DNA binding