locus-tag	class	description
MGAS2221_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
MGAS2221_RS00020	ENOG4105C3G	gtp-binding protein
MGAS2221_RS00030	ENOG4108JA2	transcriptioN-repair coupling factor
MGAS2221_RS00035	ENOG41082I2	s4 domain protein
MGAS2221_RS00050	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
MGAS2221_RS00060	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
MGAS2221_RS00065	ENOG4105CUB	amino acid
MGAS2221_RS00245	ENOG41068JE	domain protein
MGAS2221_RS00265	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
MGAS2221_RS00270	ENOG4105C8V	SAICAR synthetase
MGAS2221_RS00275	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
MGAS2221_RS00280	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
MGAS2221_RS00285	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
MGAS2221_RS00290	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
MGAS2221_RS00305	ENOG4105C12	Phosphoribosylglycinamide synthetase
MGAS2221_RS00310	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
MGAS2221_RS00325	ENOG4105C83	adenylosuccinate lyase
MGAS2221_RS00340	ENOG4105KJF	protein tyrosine phosphatase
MGAS2221_RS00355	ENOG4105C0A	alcohol dehydrogenase
MGAS2221_RS00365	ENOG4105UQX	Mate efflux family protein
MGAS2221_RS00430	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
MGAS2221_RS00475	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
MGAS2221_RS00480	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
MGAS2221_RS00500	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
MGAS2221_RS00610	ENOG4105FDK	ABC transporter
MGAS2221_RS00630	ENOG4105BZ4	penicillin-binding protein
MGAS2221_RS00635	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
MGAS2221_RS00640	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
MGAS2221_RS00700	ENOG4105II7	pyrroline-5-carboxylate reductase
MGAS2221_RS00705	ENOG4105CN9	Peptidase m42 family protein
MGAS2221_RS00720	ENOG4108VDD	TRNA binding domain protein
MGAS2221_RS00730	ENOG4105ZMH	deoxynucleoside kinase
MGAS2221_RS00735	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
MGAS2221_RS00740	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
MGAS2221_RS00760	ENOG4105YXA	Pilin isopeptide linkage domain protein
MGAS2221_RS00765	ENOG4105KFN	sortase, SrtB family
MGAS2221_RS00775	ENOG4105E5H	Transposase
MGAS2221_RS00805	ENOG4105CRW	Short chain fatty acid transporter
MGAS2221_RS00815	ENOG4105CHU	acetyl-coa acetyltransferase
MGAS2221_RS00820	ENOG4107QP7	CoA-transferase subunit A
MGAS2221_RS00835	ENOG4105KME	endoribonuclease L-psp
MGAS2221_RS00885	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
MGAS2221_RS00905	ENOG4105DIH	basic membrane
MGAS2221_RS00925	ENOG4105E5P	Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation
MGAS2221_RS00945	ENOG4105C28	cystathionine
MGAS2221_RS00975	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
MGAS2221_RS00995	ENOG4108IJ7	Glycine betaine
MGAS2221_RS01005	ENOG4105C2M	dna polymerase I
MGAS2221_RS01025	ENOG4105BZV	Phosphoadenosine phosphosulfate reductase
MGAS2221_RS01030	ENOG4105GTN	ParB Domain Protein Nuclease
MGAS2221_RS01055	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
MGAS2221_RS01070	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
MGAS2221_RS01080	ENOG41080Y5	BioY family
MGAS2221_RS01085	ENOG4108RQ5	Beta-lactamase domain-containing protein
MGAS2221_RS01110	ENOG4107QYV	phosphohexose isomerase
MGAS2221_RS01125	ENOG4105DSE	periplasmic solute binding protein
MGAS2221_RS01145	ENOG4108JJB	ABC transporter
MGAS2221_RS01195	ENOG4105D1H	recombination factor protein RarA
MGAS2221_RS01200	ENOG4105DDQ	anthranilate synthase
MGAS2221_RS01205	ENOG4105CRQ	synthase (Component I)
MGAS2221_RS01215	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
MGAS2221_RS01220	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
MGAS2221_RS01225	ENOG4105CI1	PTS System
MGAS2221_RS01265	ENOG4108IJ9	(ABC) transporter
MGAS2221_RS01275	ENOG4108IUM	Glycogen debranching enzyme
MGAS2221_RS01285	ENOG4105VIE	preprotein translocase, subunit YajC
MGAS2221_RS01290	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
MGAS2221_RS01295	ENOG4105KNE	Phosphatidate cytidylyltransferase
MGAS2221_RS01300	ENOG4105DZP	Membrane-associated zinc metalloprotease
MGAS2221_RS01305	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
MGAS2221_RS01310	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
MGAS2221_RS01340	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
MGAS2221_RS01345	ENOG4105ETD	TRANSCRIPTIONal
MGAS2221_RS01360	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
MGAS2221_RS01365	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
MGAS2221_RS01375	ENOG4105D7W	serine acetyltransferase
MGAS2221_RS01385	ENOG4105C8N	cysteinyl-tRNA synthetase
MGAS2221_RS01390	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS2221_RS01400	ENOG4105C2N	RNA methyltransferase TrmH family group 3
MGAS2221_RS01410	ENOG4105EPR	degv family
MGAS2221_RS01420	ENOG4105VZ8	Transcriptional regulator
MGAS2221_RS01425	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
MGAS2221_RS01470	ENOG4105DE4	1-phosphofructokinase
MGAS2221_RS01480	ENOG4105VCP	PTS System
MGAS2221_RS01485	ENOG4105CK1	PTS System
MGAS2221_RS01490	ENOG4105CS2	ec 3.2.1.21
MGAS2221_RS01505	ENOG4108JJA	ABC, transporter
MGAS2221_RS01510	ENOG4105C19	ABC transporter
MGAS2221_RS01545	ENOG4105DZR	Type I site-specific deoxyribonuclease
MGAS2221_RS01550	ENOG4105BZW	Glycerate kinase
MGAS2221_RS01595	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
MGAS2221_RS01600	ENOG4105CQW	ribosome biogenesis GTPase YqeH
MGAS2221_RS01605	ENOG410812S	Rna-binding protein
MGAS2221_RS01610	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
MGAS2221_RS01615	ENOG4108WF2	Metal Dependent Phosphohydrolase
MGAS2221_RS01620	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
MGAS2221_RS01625	ENOG4105DXX	methyltransferase
MGAS2221_RS01630	ENOG4105CDE	UPF0348 protein
MGAS2221_RS01645	ENOG4105D01	(LipO)protein
MGAS2221_RS01655	ENOG4108UMI	ABC transporter, permease
MGAS2221_RS01670	ENOG4107ZYR	domain protein
MGAS2221_RS01680	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
MGAS2221_RS01685	ENOG4108V0P	LemA family
MGAS2221_RS01700	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
MGAS2221_RS01730	ENOG4105C0D	helicase
MGAS2221_RS01760	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
MGAS2221_RS01770	ENOG410600T	transposase
MGAS2221_RS01775	ENOG4108RWN	rrna methyltransferase
MGAS2221_RS01785	ENOG4105HFZ	Membrane
MGAS2221_RS01795	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
MGAS2221_RS01800	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
MGAS2221_RS01815	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
MGAS2221_RS01820	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
MGAS2221_RS01830	ENOG4105FE9	pseudouridine synthase
MGAS2221_RS01845	ENOG4108SAX	Membrane
MGAS2221_RS01850	ENOG410841Q	phosphoesterase PA-phosphatase related protein
MGAS2221_RS01855	ENOG4105N5T	Radical SAM Protein
MGAS2221_RS01870	ENOG4105F1A	Pyruvate formate-lyase
MGAS2221_RS01885	ENOG4105EHG	Permease protein
MGAS2221_RS01890	ENOG4105DQ5	transport system permease protein
MGAS2221_RS01900	ENOG4105E0A	ABC, transporter
MGAS2221_RS01905	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
MGAS2221_RS01930	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
MGAS2221_RS01935	ENOG4105FA2	dna polymerase iii
MGAS2221_RS01950	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
MGAS2221_RS01965	ENOG41080E8	Transcriptional regulator, Spx MgsR family
MGAS2221_RS01970	ENOG4105CGK	Exodeoxyribonuclease III
MGAS2221_RS01990	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
MGAS2221_RS02000	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
MGAS2221_RS02050	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
MGAS2221_RS02060	ENOG4105CXY	transporter
MGAS2221_RS02065	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
MGAS2221_RS02070	ENOG4108YZ4	nudix hydrolase
MGAS2221_RS02080	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
MGAS2221_RS02095	ENOG4105DSE	periplasmic solute binding protein
MGAS2221_RS02100	ENOG4105DIK	(ABC) transporter
MGAS2221_RS02105	ENOG4105CC5	ABC transporter
MGAS2221_RS02115	ENOG4105CNU	cell division protein FtsK
MGAS2221_RS02150	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
MGAS2221_RS02170	ENOG4105C9A	Phoh family
MGAS2221_RS02175	ENOG4108RG0	uracil-dna glycosylase
MGAS2221_RS02185	ENOG4107YR5	Diacylglycerol kinase
MGAS2221_RS02190	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
MGAS2221_RS02265	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
MGAS2221_RS02270	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
MGAS2221_RS02275	ENOG4105D7A	ATP-binding protein
MGAS2221_RS02280	ENOG4105C6X	Major Facilitator
MGAS2221_RS02295	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
MGAS2221_RS02325	ENOG4105CKK	Glycosyl transferase, family 2
MGAS2221_RS02330	ENOG4108UYE	Lactoylglutathione lyase
MGAS2221_RS02335	ENOG4108RCM	Nitroreductase
MGAS2221_RS02340	ENOG4105DC7	peptidase M24
MGAS2221_RS02345	ENOG4105ETE	Transcriptional regulator (LacI family
MGAS2221_RS02350	ENOG4105W2C	Glycosyl transferase
MGAS2221_RS02355	ENOG4105BZF	Glycosyl transferase (Group 1
MGAS2221_RS02360	ENOG4105C22	threonyL-tRNA synthetase
MGAS2221_RS02365	ENOG4108IUW	ABC transporter
MGAS2221_RS02400	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
MGAS2221_RS02405	ENOG4105BZU	Histidine kinase
MGAS2221_RS02410	ENOG4105Q2H	domain protein
MGAS2221_RS02420	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
MGAS2221_RS02435	ENOG4105E2X	shikimate dehydrogenase
MGAS2221_RS02525	ENOG4105EFC	phage portal protein HK97 family
MGAS2221_RS02540	ENOG4105C5S	asparaginyl-tRNA synthetase
MGAS2221_RS02570	ENOG4108HCJ	Hydrolase
MGAS2221_RS02575	ENOG410667J	hydrolase
MGAS2221_RS02580	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MGAS2221_RS02585	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
MGAS2221_RS02590	ENOG4105CID	antiterminator
MGAS2221_RS02595	ENOG4105C5Y	PTS System
MGAS2221_RS02605	ENOG4108NNR	transporter substrate-binding protein
MGAS2221_RS02610	ENOG4108PJD	permease
MGAS2221_RS02625	ENOG410906U	SprT-like
MGAS2221_RS02665	ENOG4105CFP	Peptidase U32
MGAS2221_RS02670	ENOG4105VEM	Conserved domain protein
MGAS2221_RS02680	ENOG4105CRK	lysyL-tRNA synthetase
MGAS2221_RS02720	ENOG4108V06	Glutathione peroxidase
MGAS2221_RS02725	ENOG4105DPN	Oligoendopeptidase f
MGAS2221_RS02730	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
MGAS2221_RS02735	ENOG4105CNI	cell division protein FtsW
MGAS2221_RS02740	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
MGAS2221_RS02765	ENOG4105DCI	Phosphohydrolase
MGAS2221_RS02780	ENOG4108M60	Transcriptional regulator
MGAS2221_RS02790	ENOG4105F3R	pts system mannose fructose sorbose family iid
MGAS2221_RS02795	ENOG4105ETZ	PTS System
MGAS2221_RS02800	ENOG4108RG5	PTS system N-acetylgalactosamine-specific transporter subunit IIB
MGAS2221_RS02805	ENOG4105EP8	Glycosyl Hydrolase Family 88
MGAS2221_RS02830	ENOG4108RTU	Aldolase
MGAS2221_RS02835	ENOG4107XGZ	Hydrolase
MGAS2221_RS02840	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
MGAS2221_RS02850	ENOG4105CAK	Cell division ATP-binding protein ftsE
MGAS2221_RS02855	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
MGAS2221_RS02865	ENOG4105CHR	reductase
MGAS2221_RS02870	ENOG4105CHR	reductase
MGAS2221_RS02875	ENOG4105DVT	helicase
MGAS2221_RS02880	ENOG4105CHM	Aminotransferase
MGAS2221_RS02895	ENOG4105CHW	UPF0052 protein
MGAS2221_RS02900	ENOG4105CIE	May be required for sporulation (By similarity)
MGAS2221_RS02910	ENOG4105DSE	periplasmic solute binding protein
MGAS2221_RS02915	ENOG4105FDP	GntR family transcriptional regulator
MGAS2221_RS02920	ENOG4105E70	isomerase
MGAS2221_RS02930	ENOG4105SFS	phosphoesterase RecJ domain protein
MGAS2221_RS02945	ENOG4107R4J	Chloride channel
MGAS2221_RS02970	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MGAS2221_RS02975	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
MGAS2221_RS03040	ENOG4105CJ1	ABC, transporter
MGAS2221_RS03060	ENOG410807C	QueT transporter
MGAS2221_RS03065	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
MGAS2221_RS03070	ENOG4105CBD	Diacylglycerol kinase
MGAS2221_RS03075	ENOG4105ZA1	atp synthase
MGAS2221_RS03080	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
MGAS2221_RS03085	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
MGAS2221_RS03090	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
MGAS2221_RS03105	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
MGAS2221_RS03110	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
MGAS2221_RS03120	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
MGAS2221_RS03130	ENOG4105ZT7	DNA-entry nuclease
MGAS2221_RS03135	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
MGAS2221_RS03140	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
MGAS2221_RS03155	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
MGAS2221_RS03165	ENOG4105CGZ	zinc metallopeptidase
MGAS2221_RS03170	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MGAS2221_RS03175	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
MGAS2221_RS03180	ENOG4106PMH	Extracellular solute-binding protein family 3
MGAS2221_RS03190	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
MGAS2221_RS03195	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
MGAS2221_RS03200	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
MGAS2221_RS03205	ENOG4105VG1	fes assembly suf system protein
MGAS2221_RS03210	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
MGAS2221_RS03230	ENOG4105EY8	ABC transporter
MGAS2221_RS03250	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
MGAS2221_RS03270	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
MGAS2221_RS03315	ENOG4105DR4	Methyltransferase
MGAS2221_RS03325	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
MGAS2221_RS03335	ENOG4105DC8	reductase
MGAS2221_RS03340	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
MGAS2221_RS03350	ENOG4105C3J	Cysteine desulfurase
MGAS2221_RS03375	ENOG4105K46	50S ribosomal protein l27
MGAS2221_RS03380	ENOG4105CMU	LysR family (Transcriptional regulator
MGAS2221_RS03385	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
MGAS2221_RS03390	ENOG4105C34	Pseudouridine synthase
MGAS2221_RS03415	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
MGAS2221_RS03420	ENOG4107X8C	Efflux transporter RND family MFP subunit
MGAS2221_RS03425	ENOG4105C19	ABC transporter
MGAS2221_RS03430	ENOG4107RBB	ABC transporter, permease
MGAS2221_RS03435	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
MGAS2221_RS03445	ENOG4105VB6	UPF0109 protein
MGAS2221_RS03470	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
MGAS2221_RS03475	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
MGAS2221_RS03495	ENOG4105E98	transcriptional regulator DeoR family
MGAS2221_RS03500	ENOG4105DE4	1-phosphofructokinase
MGAS2221_RS03505	ENOG4105DM4	PTS System
MGAS2221_RS03510	ENOG4107X35	defense response to bacterium
MGAS2221_RS03515	ENOG4107X35	defense response to bacterium
MGAS2221_RS03545	ENOG4105EPR	degv family
MGAS2221_RS03550	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MGAS2221_RS03555	ENOG4105C5H	ABC transporter
MGAS2221_RS03565	ENOG4107YDN	peptide deformylase
MGAS2221_RS03570	ENOG4105CGH	5'-nucleotidase
MGAS2221_RS03580	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
MGAS2221_RS03615	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
MGAS2221_RS03625	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
MGAS2221_RS03640	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
MGAS2221_RS03685	ENOG4107RSM	transcriptional regulator
MGAS2221_RS03695	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
MGAS2221_RS03700	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
MGAS2221_RS03710	ENOG4105E89	ABC transporter
MGAS2221_RS03715	ENOG4105E5Q	amino acid AbC transporter
MGAS2221_RS03725	ENOG4105CD3	dihydroorotase
MGAS2221_RS03735	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MGAS2221_RS03745	ENOG4105CM2	brancheD-chain amino acid aminotransferase
MGAS2221_RS03765	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
MGAS2221_RS03810	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
MGAS2221_RS03815	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
MGAS2221_RS03825	ENOG4108IXY	short-chain dehydrogenase reductase
MGAS2221_RS03830	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
MGAS2221_RS03845	ENOG4105CSM	endonuclease III
MGAS2221_RS03860	ENOG4107VFR	oxidoreductase
MGAS2221_RS03865	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
MGAS2221_RS03875	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
MGAS2221_RS03890	ENOG41068YB	TPR repeat-containing protein
MGAS2221_RS03910	ENOG4105C2J	ABC transporter
MGAS2221_RS03920	ENOG4107UWA	esterase
MGAS2221_RS03930	ENOG4105C5H	ABC transporter
MGAS2221_RS03935	ENOG4107RUY	(E1 component), alpha subunit
MGAS2221_RS03940	ENOG4105CPP	Dehydrogenase, E1 component
MGAS2221_RS03950	ENOG4107QN2	dihydrolipoyl dehydrogenase
MGAS2221_RS03965	ENOG4106AM8	polysaccharide lyase family 8
MGAS2221_RS03970	ENOG4105DF9	Lipoate-protein, ligase
MGAS2221_RS03975	ENOG4105F1K	Glutamine amidotransferase
MGAS2221_RS03980	ENOG4105DMS	mur ligase
MGAS2221_RS03985	ENOG4105C8B	TIGR00159 family
MGAS2221_RS03995	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
MGAS2221_RS04005	ENOG4105CSA	Coproporphyrinogen iii oxidase
MGAS2221_RS04015	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
MGAS2221_RS04050	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
MGAS2221_RS04060	ENOG4105E0X	reductase
MGAS2221_RS04065	ENOG4105HMI	Membrane
MGAS2221_RS04080	ENOG4105ETZ	PTS System
MGAS2221_RS04085	ENOG4105F3R	pts system mannose fructose sorbose family iid
MGAS2221_RS04090	ENOG4105C2F	Histidine kinase
MGAS2221_RS04095	ENOG4107VQW	regulatoR
MGAS2221_RS04100	ENOG4105C4Y	ABC transporter
MGAS2221_RS04120	ENOG4105C26	Dehydrogenase
MGAS2221_RS04125	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
MGAS2221_RS04135	ENOG4107QSE	Dipeptidase
MGAS2221_RS04140	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
MGAS2221_RS04145	ENOG4108VZM	50s ribosomal protein L10
MGAS2221_RS04200	ENOG4105DA5	(ABC) transporter
MGAS2221_RS04215	ENOG4108IMY	Transcriptional regulator
MGAS2221_RS04245	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
MGAS2221_RS04255	ENOG4105EEI	dihydropteroate synthase
MGAS2221_RS04265	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS2221_RS04270	ENOG4105D4A	Cell wall formation (By similarity)
MGAS2221_RS04280	ENOG4105F38	ABC transporter, permease
MGAS2221_RS04285	ENOG4105D38	putrescine abc transporter
MGAS2221_RS04290	ENOG4108HM4	ABC transporter
MGAS2221_RS04295	ENOG4108MRH	transcriptional regulatory protein
MGAS2221_RS04320	ENOG4105F0S	class B acid phosphatase
MGAS2221_RS04325	ENOG4105CMQ	Chloride channel
MGAS2221_RS04360	ENOG4105C3J	Cysteine desulfurase
MGAS2221_RS04365	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
MGAS2221_RS04385	ENOG4108YBP	pseudouridine synthase
MGAS2221_RS04390	ENOG4108IJ2	phosphate acetyltransferase
MGAS2221_RS04410	ENOG4105E90	ABC transporter
MGAS2221_RS04415	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
MGAS2221_RS04440	ENOG4107104	thymidine kinase
MGAS2221_RS04450	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
MGAS2221_RS04465	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
MGAS2221_RS04475	ENOG41065S2	pneumococcal vaccine antigen
MGAS2221_RS04480	ENOG4105BZ1	(ABC) transporter
MGAS2221_RS04485	ENOG4105BZ1	(ABC) transporter
MGAS2221_RS04500	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MGAS2221_RS04505	ENOG4108Z6X	(sortase) family
MGAS2221_RS04510	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
MGAS2221_RS04525	ENOG4108UT2	hemolysin iii
MGAS2221_RS04540	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
MGAS2221_RS04545	ENOG4105C79	DNA protecting protein DprA
MGAS2221_RS04550	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
MGAS2221_RS04565	ENOG4107RBM	d-lactate dehydrogenase
MGAS2221_RS04580	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
MGAS2221_RS04585	ENOG4107QSA	Oxaloacetate decarboxylase
MGAS2221_RS04595	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
MGAS2221_RS04600	ENOG4105D9Q	decarboxylase (Beta subunit)
MGAS2221_RS04615	ENOG4105D4T	Citrate transporter
MGAS2221_RS04625	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
MGAS2221_RS04630	ENOG4105D9Q	decarboxylase (Beta subunit)
MGAS2221_RS04650	ENOG4105YGP	holo-ACP synthase CitX
MGAS2221_RS04655	ENOG4107QSA	Oxaloacetate decarboxylase
MGAS2221_RS04660	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
MGAS2221_RS04680	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS2221_RS04710	ENOG4105C5H	ABC transporter
MGAS2221_RS04720	ENOG4105DWF	phosphomethylpyrimidine kinase
MGAS2221_RS04730	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
MGAS2221_RS04735	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
MGAS2221_RS04755	ENOG4108UVJ	appr-1-p processing domain protein
MGAS2221_RS04765	ENOG4105DEN	Luciferase family
MGAS2221_RS04775	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
MGAS2221_RS04785	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
MGAS2221_RS04790	ENOG4105FH5	Membrane
MGAS2221_RS04805	ENOG4105UIB	(ABC) transporter
MGAS2221_RS04810	ENOG4108JQ9	ABC transporter
MGAS2221_RS04815	ENOG4105DIH	basic membrane
MGAS2221_RS04820	ENOG4105KG3	cytidine deaminase
MGAS2221_RS04825	ENOG4107Y49	methyltransferase
MGAS2221_RS04840	ENOG4105US7	Histidine kinase
MGAS2221_RS04845	ENOG4108STX	response regulator
MGAS2221_RS04855	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
MGAS2221_RS04870	ENOG4105E2Z	phosphate ABC transporter (Permease
MGAS2221_RS04875	ENOG4105C8U	phosphate abc transporter
MGAS2221_RS04885	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
MGAS2221_RS04890	ENOG4105ECY	inositol monophosphatase
MGAS2221_RS04900	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
MGAS2221_RS04905	ENOG4105DTN	riboflavin biosynthesis protein ribF
MGAS2221_RS04910	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
MGAS2221_RS04935	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
MGAS2221_RS04985	ENOG4105BZG	amino acid carrier protein
MGAS2221_RS05000	ENOG4106TNF	Periplasmic binding protein
MGAS2221_RS05005	ENOG4105CDA	abc transporter atp-binding protein
MGAS2221_RS05010	ENOG4105E5Q	amino acid AbC transporter
MGAS2221_RS05015	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
MGAS2221_RS05020	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
MGAS2221_RS05030	ENOG4105CA9	Pyruvate kinase
MGAS2221_RS05035	ENOG4105CTQ	phosphohexokinase
MGAS2221_RS05040	ENOG4105C0B	DNA polymerase III (alpha subunit)
MGAS2221_RS05045	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
MGAS2221_RS05050	ENOG4105CZV	ABC transporter
MGAS2221_RS05205	ENOG4105IG6	Phage terminase, large subunit
MGAS2221_RS05355	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
MGAS2221_RS05360	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
MGAS2221_RS05365	ENOG4105FKQ	transcriptional regulator
MGAS2221_RS05370	ENOG4107FKK	extracellular solute-binding protein family 1
MGAS2221_RS05380	ENOG4105EG2	ABC transporter, permease
MGAS2221_RS05385	ENOG4105ETE	Transcriptional regulator (LacI family
MGAS2221_RS05390	ENOG4108VP7	maltodextrose utilization protein MalA
MGAS2221_RS05395	ENOG4105EG2	ABC transporter, permease
MGAS2221_RS05400	ENOG4105D56	permease protein
MGAS2221_RS05410	ENOG4108IUK	alpha amylase, catalytic
MGAS2221_RS05415	ENOG4107FKK	extracellular solute-binding protein family 1
MGAS2221_RS05425	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
MGAS2221_RS05435	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
MGAS2221_RS05455	ENOG4107R0W	ABC transporter
MGAS2221_RS05460	ENOG4105CDA	abc transporter atp-binding protein
MGAS2221_RS05470	ENOG4105CK1	PTS System
MGAS2221_RS05480	ENOG4105VCP	PTS System
MGAS2221_RS05490	ENOG4105EMD	TRANSCRIPTIONal
MGAS2221_RS05500	ENOG4105CS2	ec 3.2.1.21
MGAS2221_RS05515	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MGAS2221_RS05540	ENOG4107RGD	Major Facilitator superfamily
MGAS2221_RS05545	ENOG4105DPH	UPF0371 protein
MGAS2221_RS05560	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
MGAS2221_RS05575	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
MGAS2221_RS05595	ENOG4105D9U	N-acetyltransferase
MGAS2221_RS05610	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
MGAS2221_RS05620	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
MGAS2221_RS05630	ENOG4105C6E	dna polymerase iii
MGAS2221_RS05635	ENOG4108ZGC	gaf domain protein
MGAS2221_RS05655	ENOG4105FDU	atp-dependent rna helicase
MGAS2221_RS05660	ENOG4108ZJ4	polysaccharide deacetylase
MGAS2221_RS05665	ENOG4105C26	Dehydrogenase
MGAS2221_RS05670	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
MGAS2221_RS05675	ENOG4105KRI	phosphocarrier protein (HPr
MGAS2221_RS05680	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
MGAS2221_RS05685	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
MGAS2221_RS05690	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
MGAS2221_RS05720	ENOG4105VZ8	Transcriptional regulator
MGAS2221_RS05725	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
MGAS2221_RS05760	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
MGAS2221_RS05765	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
MGAS2221_RS05790	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
MGAS2221_RS05800	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
MGAS2221_RS05805	ENOG4105KQC	Competence protein
MGAS2221_RS05810	ENOG4105F6E	Acyl-transferase
MGAS2221_RS05815	ENOG41060K3	Methyltransferase
MGAS2221_RS05825	ENOG4105DFH	Transport of potassium into the cell (By similarity)
MGAS2221_RS05830	ENOG4105C1J	atp-dependent rna helicase
MGAS2221_RS05845	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
MGAS2221_RS05860	ENOG4107RF6	penicillin-binding protein
MGAS2221_RS05865	ENOG4105TMB	Formate nitrite transporter
MGAS2221_RS05870	ENOG4105RNB	
MGAS2221_RS05885	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
MGAS2221_RS05890	ENOG4105C59	p-type ATPase
MGAS2221_RS06075	ENOG4108PNI	recT protein
MGAS2221_RS06135	ENOG4105XB7	anti-repressor protein
MGAS2221_RS06180	ENOG41090WU	lipolytic protein G-D-S-L family
MGAS2221_RS06185	ENOG4108RCR	degv family
MGAS2221_RS06195	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
MGAS2221_RS06200	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
MGAS2221_RS06205	ENOG4105DX0	Hemolysin A
MGAS2221_RS06235	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
MGAS2221_RS06245	ENOG4105E5Q	amino acid AbC transporter
MGAS2221_RS06250	ENOG4107IN1	Protein of unknown function (DUF1797)
MGAS2221_RS06255	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
MGAS2221_RS06260	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
MGAS2221_RS06270	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
MGAS2221_RS06275	ENOG4105MMF	Cell division protein DIVIVA
MGAS2221_RS06280	ENOG4105DBK	s4 domain protein
MGAS2221_RS06295	ENOG4105DFA	alanine racemase domain protein
MGAS2221_RS06315	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
MGAS2221_RS06320	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
MGAS2221_RS06330	ENOG4105CI3	gtp-binding protein typa
MGAS2221_RS06335	ENOG4107YZP	Rhodanese domain protein
MGAS2221_RS06340	ENOG4105DKQ	ROK family
MGAS2221_RS06350	ENOG4105HUF	DNA protection during starvation protein
MGAS2221_RS06365	ENOG4105MMD	transcriptional regulator
MGAS2221_RS06375	ENOG41063PX	domain protein
MGAS2221_RS06385	ENOG4106H78	methyltransferase
MGAS2221_RS06390	ENOG4105CU9	asparagine synthetase A
MGAS2221_RS06395	ENOG4105C5B	carbamate kinase
MGAS2221_RS06400	ENOG4107QSE	Dipeptidase
MGAS2221_RS06405	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
MGAS2221_RS06420	ENOG4105CEU	Arginine dihydrolase
MGAS2221_RS06445	ENOG4105C2F	Histidine kinase
MGAS2221_RS06460	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MGAS2221_RS06465	ENOG4107QIV	Cytochrome c biogenesis protein
MGAS2221_RS06470	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
MGAS2221_RS06475	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
MGAS2221_RS06505	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
MGAS2221_RS06535	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
MGAS2221_RS06555	ENOG4105DVA	methyltransferase
MGAS2221_RS06565	ENOG4105CNT	hydrolase family 2
MGAS2221_RS06570	ENOG4105EQD	regulatoR
MGAS2221_RS06575	ENOG4105C2F	Histidine kinase
MGAS2221_RS06590	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
MGAS2221_RS06600	ENOG41066F8	ROK family
MGAS2221_RS06605	ENOG4105CS2	ec 3.2.1.21
MGAS2221_RS06610	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
MGAS2221_RS06625	ENOG4105C8I	hydrolase, family 38
MGAS2221_RS06635	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
MGAS2221_RS06640	ENOG410902V	Modulates RecA activity (By similarity)
MGAS2221_RS06725	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
MGAS2221_RS06745	ENOG4105WH1	Two component transcriptional regulator luxr family
MGAS2221_RS06750	ENOG4105ENE	Histidine kinase
MGAS2221_RS06760	ENOG4105D9P	serine threonine protein kinase
MGAS2221_RS06770	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
MGAS2221_RS06775	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
MGAS2221_RS06780	ENOG4105C25	Primosomal protein n'
MGAS2221_RS06790	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
MGAS2221_RS06800	ENOG4105CMU	LysR family (Transcriptional regulator
MGAS2221_RS06810	ENOG4107QP7	CoA-transferase subunit A
MGAS2221_RS06820	ENOG4105DTD	Dehydrogenase
MGAS2221_RS06825	ENOG4105CY2	Citrate transporter
MGAS2221_RS06835	ENOG41070VT	
MGAS2221_RS06840	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
MGAS2221_RS06855	ENOG4108UKS	UPF0398 protein
MGAS2221_RS06860	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
MGAS2221_RS06865	ENOG4105BZ4	penicillin-binding protein
MGAS2221_RS06870	ENOG4105CTZ	aminopeptidase c
MGAS2221_RS06875	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
MGAS2221_RS06880	ENOG4105DAP	Nicotinate phosphoribosyltransferase
MGAS2221_RS06885	ENOG4105C85	amino acid
MGAS2221_RS06890	ENOG4105C3M	thioredoxin reductase
MGAS2221_RS06900	ENOG4105CDA	abc transporter atp-binding protein
MGAS2221_RS06905	ENOG4105E5Q	amino acid AbC transporter
MGAS2221_RS06910	ENOG4105C1J	atp-dependent rna helicase
MGAS2221_RS06920	ENOG4105CJN	penicillin-binding protein
MGAS2221_RS06940	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
MGAS2221_RS06945	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
MGAS2221_RS06980	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
MGAS2221_RS06985	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
MGAS2221_RS06990	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
MGAS2221_RS07010	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
MGAS2221_RS07020	ENOG4108WWS	isoprenylcysteine carboxyl methyltransferase
MGAS2221_RS07030	ENOG4105CE4	GlcNAc 6-P deacetylase
MGAS2221_RS07045	ENOG4108S8M	degv family
MGAS2221_RS07055	ENOG410667J	hydrolase
MGAS2221_RS07060	ENOG4105EN6	Membrane
MGAS2221_RS07115	ENOG4105C59	p-type ATPase
MGAS2221_RS07120	ENOG4105NA0	Transcriptional regulator
MGAS2221_RS07145	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
MGAS2221_RS07150	ENOG4105CHV	Transcription elongation factor NusA
MGAS2221_RS07170	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
MGAS2221_RS07290	ENOG4105IG6	Phage terminase, large subunit
MGAS2221_RS07420	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
MGAS2221_RS07450	ENOG4105K59	histidine triad (HIT) protein
MGAS2221_RS07460	ENOG4108KGH	TRANSCRIPTIONal
MGAS2221_RS07470	ENOG4105K8N	protein family UPF0079, ATPase
MGAS2221_RS07475	ENOG4105C7N	Xanthine uracil vitamin C permease
MGAS2221_RS07480	ENOG4108KP7	hydrolase
MGAS2221_RS07490	ENOG4105ETZ	PTS System
MGAS2221_RS07495	ENOG4105F3R	pts system mannose fructose sorbose family iid
MGAS2221_RS07505	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
MGAS2221_RS07520	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
MGAS2221_RS07535	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
MGAS2221_RS07540	ENOG4105CHR	reductase
MGAS2221_RS07545	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
MGAS2221_RS07570	ENOG4105CGU	Enoyl-CoA hydratase
MGAS2221_RS07575	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
MGAS2221_RS07605	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
MGAS2221_RS07610	ENOG4107BMA	Transglycosylase associated protein
MGAS2221_RS07620	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
MGAS2221_RS07625	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
MGAS2221_RS07650	ENOG4105CHM	Aminotransferase
MGAS2221_RS07665	ENOG4107RB3	L-asparaginase
MGAS2221_RS07680	ENOG4105CB5	ATP-dependent DNA helicase recG
MGAS2221_RS07685	ENOG4108JJB	ABC transporter
MGAS2221_RS07700	ENOG4105BZ1	(ABC) transporter
MGAS2221_RS07705	ENOG4108JJ9	ABC, transporter
MGAS2221_RS07710	ENOG4105E0A	ABC, transporter
MGAS2221_RS07735	ENOG41068JE	domain protein
MGAS2221_RS07740	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
MGAS2221_RS07755	ENOG410600T	transposase
MGAS2221_RS07760	ENOG4105DG6	mannose-6-phosphate isomerase
MGAS2221_RS07765	ENOG4105EVU	fructokinase
MGAS2221_RS07775	ENOG4105C5Y	PTS System
MGAS2221_RS07785	ENOG4105ETE	Transcriptional regulator (LacI family
MGAS2221_RS07790	ENOG4105M7K	Involved in the transcription termination process (By similarity)
MGAS2221_RS07805	ENOG4108UK2	deaminase
MGAS2221_RS07810	ENOG4105DC7	peptidase M24
MGAS2221_RS07815	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
MGAS2221_RS07850	ENOG4105CEN	a g-specific adenine glycosylase
MGAS2221_RS07860	ENOG4105K63	Thioredoxin
MGAS2221_RS07870	ENOG4105C98	muts2 protein
MGAS2221_RS07885	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
MGAS2221_RS07890	ENOG4105C3F	Signal peptidase i
MGAS2221_RS07895	ENOG4105C7H	Helicase, RecD TraA family
MGAS2221_RS07905	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
MGAS2221_RS07910	ENOG4105C6N	Formate acetyltransferase
MGAS2221_RS07915	ENOG4107S1E	Beta-lactamase
MGAS2221_RS07930	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
MGAS2221_RS07940	ENOG4105CZM	Major Facilitator
MGAS2221_RS07945	ENOG4105TV1	Transcriptional regulator
MGAS2221_RS07950	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
MGAS2221_RS07970	ENOG4107TXC	Transcriptional regulator
MGAS2221_RS07985	ENOG4105CBX	hi0933 family
MGAS2221_RS07995	ENOG4105D9N	nucleoside
MGAS2221_RS08000	ENOG4108I5U	Uridine phosphorylase
MGAS2221_RS08020	ENOG410801F	ribosomal-protein-alanine acetyltransferase
MGAS2221_RS08025	ENOG41072GX	Peptidase M22 Glycoprotease
MGAS2221_RS08040	ENOG4105C5F	glutamine synthetase
MGAS2221_RS08045	ENOG4105KV4	Transcriptional regulator
MGAS2221_RS08055	ENOG4105BZA	Phosphoglycerate kinase
MGAS2221_RS08060	ENOG4105CUR	5'-nucleotidase, lipoprotein e(p4) family
MGAS2221_RS08080	ENOG410600T	transposase
MGAS2221_RS08090	ENOG4105D2N	Aldolase
MGAS2221_RS08120	ENOG4105D8X	mechanosensitive ion channel
MGAS2221_RS08130	ENOG4105PUK	Membrane
MGAS2221_RS08135	ENOG4105DWF	phosphomethylpyrimidine kinase
MGAS2221_RS08180	ENOG4105DQ6	Transposase
MGAS2221_RS08185	ENOG4108JQ7	(ABC) transporter
MGAS2221_RS08190	ENOG4105C3U	ABC transporter
MGAS2221_RS08195	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
MGAS2221_RS08200	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
MGAS2221_RS08205	ENOG4105DIB	Oligopeptide-binding protein
MGAS2221_RS08225	ENOG4108UNV	SUF system FeS assembly protein, NifU family
MGAS2221_RS08230	ENOG4105C9B	Cysteine desulfurase
MGAS2221_RS08235	ENOG4105JRK	feS assembly protein SufD
MGAS2221_RS08245	ENOG4105ESV	Glycosyl transferase, family 4
MGAS2221_RS08265	ENOG4105E5Q	amino acid AbC transporter
MGAS2221_RS08270	ENOG4108JEH	abc transporter atp-binding protein
MGAS2221_RS08280	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
MGAS2221_RS08290	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
MGAS2221_RS08305	ENOG4105DFT	pur operon repressor
MGAS2221_RS08310	ENOG4105EQI	Metal Dependent Phosphohydrolase
MGAS2221_RS08320	ENOG4105FJ0	thiamine
MGAS2221_RS08325	ENOG4105DJV	ribulose-phosphate 3-epimerase
MGAS2221_RS08330	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
MGAS2221_RS08345	ENOG4105F8V	Hydrolase, tatD family
MGAS2221_RS08370	ENOG4105DRS	transport system, permease
MGAS2221_RS08375	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
MGAS2221_RS08385	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
MGAS2221_RS08440	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
MGAS2221_RS08445	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
MGAS2221_RS08450	ENOG4105WPN	DNA integration recombination invertion protein
MGAS2221_RS08455	ENOG4105BZ1	(ABC) transporter
MGAS2221_RS08460	ENOG4105BZ1	(ABC) transporter
MGAS2221_RS08480	ENOG4107ZXI	Rhomboid family
MGAS2221_RS08485	ENOG410600T	transposase
MGAS2221_RS08495	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
MGAS2221_RS08525	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
MGAS2221_RS08535	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
MGAS2221_RS08540	ENOG4107RBB	ABC transporter, permease
MGAS2221_RS08545	ENOG4105C19	ABC transporter
MGAS2221_RS08585	ENOG4105JBQ	Pyrogenic exotoxin B
MGAS2221_RS08600	ENOG4108W5N	phosphatidylglycerophosphatase a
MGAS2221_RS08620	ENOG4105CK1	PTS System
MGAS2221_RS08625	ENOG4105VZJ	PTS System
MGAS2221_RS08630	ENOG4105VCP	PTS System
MGAS2221_RS08635	ENOG4107RHR	regulatoR
MGAS2221_RS08640	ENOG4105E98	transcriptional regulator DeoR family
MGAS2221_RS08645	ENOG4105F1A	Pyruvate formate-lyase
MGAS2221_RS08665	ENOG4105BZ4	penicillin-binding protein
MGAS2221_RS08680	ENOG4108YBP	pseudouridine synthase
MGAS2221_RS08690	ENOG4105DZW	Dipeptidase
MGAS2221_RS08700	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
MGAS2221_RS08710	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
MGAS2221_RS08730	ENOG4105D3R	alkyl hydroperoxide reductase
MGAS2221_RS08740	ENOG4105CI2	imidazolone-5-propionate hydrolase
MGAS2221_RS08745	ENOG4105CGP	Urocanate hydratase
MGAS2221_RS08750	ENOG4105CCS	Glutamate formiminotransferase
MGAS2221_RS08755	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
MGAS2221_RS08760	ENOG4105CKU	formyltetrahydrofolate synthetase
MGAS2221_RS08770	ENOG4107R7I	amino acid
MGAS2221_RS08775	ENOG4105C84	Histidine ammonia-lyase
MGAS2221_RS08790	ENOG4105CE9	30S ribosomal protein S2
MGAS2221_RS08795	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
MGAS2221_RS08800	ENOG4105C9K	Endothelin-converting enzyme 1
MGAS2221_RS08805	ENOG4105CG3	alpha amylase, catalytic region
MGAS2221_RS08810	ENOG4105C5Y	PTS System
MGAS2221_RS08815	ENOG4107414	GntR family transcriptional regulator
MGAS2221_RS08820	ENOG4105KVH	Transcriptional regulator
MGAS2221_RS08825	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
MGAS2221_RS08835	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
MGAS2221_RS08845	ENOG4105EP9	oxidoreductase
MGAS2221_RS08855	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
MGAS2221_RS08870	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
MGAS2221_RS08880	ENOG410888K	transcriptional regulator, Spx
MGAS2221_RS08885	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
MGAS2221_RS08890	ENOG4105CEV	competence damage-inducible protein
MGAS2221_RS08895	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
MGAS2221_RS08905	ENOG4105D94	Major Facilitator Superfamily
MGAS2221_RS08910	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
MGAS2221_RS08915	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
MGAS2221_RS08925	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
MGAS2221_RS08940	ENOG4108JYZ	YitT family
MGAS2221_RS08945	ENOG4108JYZ	YitT family
MGAS2221_RS08950	ENOG4107AYK	membrAne
MGAS2221_RS08955	ENOG4105C9M	aspartyl-trna synthetase
MGAS2221_RS08960	ENOG4105CUT	histidyl-tRNA synthetase
MGAS2221_RS09035	ENOG4105ECB	domain protein
MGAS2221_RS09050	ENOG410600T	transposase
MGAS2221_RS09060	ENOG4105CDU	Replicative dna helicase
MGAS2221_RS09075	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
MGAS2221_RS09085	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
MGAS2221_RS09095	ENOG4105EJQ	L-serine dehydratase
MGAS2221_RS09100	ENOG4106770	Is able to cleave peptidoglycan (By similarity)
MGAS2221_RS09105	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
MGAS2221_RS09115	ENOG4108JJB	ABC transporter
MGAS2221_RS09120	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
MGAS2221_RS09140	ENOG4108NV9	Glycosyl Transferase
MGAS2221_RS09150	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
MGAS2221_RS09160	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
MGAS2221_RS09170	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
MGAS2221_RS09175	ENOG4105C31	Tryptophanyl-tRNA synthetase
MGAS2221_RS09185	ENOG4105C5H	ABC transporter
MGAS2221_RS09220	ENOG4105C0H	protease
MGAS2221_RS09225	ENOG4105FA0	parb-like partition protein