locus-tag	class	description
MGAS2221_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS2221_RS00020	COG0012	GTP binding
MGAS2221_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS2221_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS2221_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS2221_RS00065	COG0531	amino acid
MGAS2221_RS00245	COG3942	CHAP domain
MGAS2221_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS2221_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS2221_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS2221_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS2221_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS2221_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS2221_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
MGAS2221_RS00355	COG1454	alcohol dehydrogenase
MGAS2221_RS00360	COG1064	alcohol dehydrogenase
MGAS2221_RS00365	COG0534	Mate efflux family protein
MGAS2221_RS00475	COG0201	protein transport
MGAS2221_RS00610	COG1121	(ABC) transporter
MGAS2221_RS00615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS2221_RS00630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS2221_RS00650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS2221_RS00655	COG1459	type II secretion system
MGAS2221_RS00660	COG4537	Required for transformation and DNA binding
MGAS2221_RS00700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS2221_RS00705	COG1363	Peptidase, m42
MGAS2221_RS00715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS2221_RS00720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS2221_RS00730	COG1428	Deoxynucleoside kinase
MGAS2221_RS00735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS2221_RS00765	COG4509	Sortase family
MGAS2221_RS00775	COG4372	Transposase
MGAS2221_RS00805	COG2031	fatty acid transporter
MGAS2221_RS00820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS2221_RS00835	COG0251	oxidation-reduction process
MGAS2221_RS00850	COG1269	ATP hydrolysis coupled proton transport
MGAS2221_RS00855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS2221_RS00865	COG1527	subunit (C
MGAS2221_RS00870	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS2221_RS00905	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS2221_RS00945	COG0626	cystathionine gamma-synthase activity
MGAS2221_RS00975	COG3623	hexulose-6-phosphate isomerase
MGAS2221_RS00995	COG4175	Glycine betaine
MGAS2221_RS00995	COG3448	diguanylate cyclase activity
MGAS2221_RS01005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS2221_RS01005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS2221_RS01025	COG3969	phosphoadenosine phosphosulfate
MGAS2221_RS01030	COG1475	DNA binding
MGAS2221_RS01055	COG0157	Belongs to the NadC ModD family
MGAS2221_RS01080	COG1268	BioY protein
MGAS2221_RS01085	COG1234	tRNA 3'-trailer cleavage
MGAS2221_RS01125	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS2221_RS01145	COG1122	ATPase activity
MGAS2221_RS01155	COG0601	transmembrane transport
MGAS2221_RS01195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS2221_RS01200	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS2221_RS01205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS2221_RS01220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS2221_RS01225	COG2190	(PTS) system
MGAS2221_RS01225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS2221_RS01225	COG1263	PTS System
MGAS2221_RS01265	COG3842	ATPase activity
MGAS2221_RS01275	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS2221_RS01285	COG1862	Preprotein translocase
MGAS2221_RS01295	COG4589	Belongs to the CDS family
MGAS2221_RS01315	COG1846	Transcriptional regulator
MGAS2221_RS01345	COG3711	transcriptional antiterminator
MGAS2221_RS01360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS2221_RS01375	COG1045	serine acetyltransferase
MGAS2221_RS01390	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS2221_RS01400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS2221_RS01420	COG1476	TRANSCRIPTIONal
MGAS2221_RS01425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS2221_RS01480	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS2221_RS01485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS2221_RS01485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS2221_RS01505	COG2274	protein secretion by the type I secretion system
MGAS2221_RS01510	COG1136	(ABC) transporter
MGAS2221_RS01515	COG0577	efflux transmembrane transporter activity
MGAS2221_RS01545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS2221_RS01550	COG1929	Belongs to the glycerate kinase type-1 family
MGAS2221_RS01595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS2221_RS01600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS2221_RS01605	COG1534	Rna-binding protein
MGAS2221_RS01615	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS2221_RS01620	COG0799	negative regulation of ribosome biogenesis
MGAS2221_RS01625	COG2226	methyltransferase
MGAS2221_RS01640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS2221_RS01645	COG1464	Belongs to the NlpA lipoprotein family
MGAS2221_RS01660	COG1114	Component of the transport system for branched-chain amino acids
MGAS2221_RS01670	COG0569	domain protein
MGAS2221_RS01675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS2221_RS01685	COG1704	LemA family
MGAS2221_RS01700	COG0745	RESPONSE REGULATOR receiver
MGAS2221_RS01720	COG1484	DNA-dependent DNA replication
MGAS2221_RS01730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS2221_RS01750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS2221_RS01765	COG1254	Belongs to the acylphosphatase family
MGAS2221_RS01770	COG5433	transposase activity
MGAS2221_RS01775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS2221_RS01830	COG1187	pseudouridine synthase activity
MGAS2221_RS01845	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS2221_RS01850	COG0671	phosphoesterase, PA-phosphatase related
MGAS2221_RS01855	COG1242	4 iron, 4 sulfur cluster binding
MGAS2221_RS01860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS2221_RS01865	COG1253	flavin adenine dinucleotide binding
MGAS2221_RS01870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS2221_RS01885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS2221_RS01890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS2221_RS01895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS2221_RS01900	COG1120	ATPase activity
MGAS2221_RS01910	COG2244	polysaccharide biosynthetic process
MGAS2221_RS01935	COG0470	DNA polymerase III
MGAS2221_RS01965	COG1393	Belongs to the ArsC family
MGAS2221_RS01970	COG0708	Exodeoxyribonuclease III
MGAS2221_RS01975	COG1304	FMN binding
MGAS2221_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS2221_RS02055	COG0673	inositol 2-dehydrogenase activity
MGAS2221_RS02070	COG0494	nUDIX hydrolase
MGAS2221_RS02080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS2221_RS02170	COG1702	phosphate starvation-inducible protein PhoH
MGAS2221_RS02175	COG1573	uracil-dna glycosylase
MGAS2221_RS02185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS2221_RS02275	COG0433	COG0433 Predicted ATPase
MGAS2221_RS02280	COG2814	Major facilitator Superfamily
MGAS2221_RS02295	COG0557	exoribonuclease II activity
MGAS2221_RS02325	COG0463	Glycosyl transferase, family 2
MGAS2221_RS02335	COG0778	Nitroreductase
MGAS2221_RS02340	COG0006	proline dipeptidase activity
MGAS2221_RS02345	COG1609	Transcriptional regulator
MGAS2221_RS02355	COG0438	transferase activity, transferring glycosyl groups
MGAS2221_RS02365	COG4555	ABC transporter
MGAS2221_RS02385	COG0183	Belongs to the thiolase family
MGAS2221_RS02400	COG0745	RESPONSE REGULATOR receiver
MGAS2221_RS02405	COG5002	protein histidine kinase activity
MGAS2221_RS02410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS2221_RS02420	COG1196	nuclear chromosome segregation
MGAS2221_RS02435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS2221_RS02525	COG4695	Portal protein
MGAS2221_RS02570	COG0561	phosphatase activity
MGAS2221_RS02575	COG0561	phosphatase activity
MGAS2221_RS02580	COG0552	protein localization to endoplasmic reticulum
MGAS2221_RS02585	COG0477	Major facilitator Superfamily
MGAS2221_RS02590	COG3711	transcriptional antiterminator
MGAS2221_RS02595	COG1263	PTS System
MGAS2221_RS02595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS2221_RS02595	COG2190	(PTS) system
MGAS2221_RS02605	COG3689	TIGRFAM TIGR03943 family protein
MGAS2221_RS02610	COG0701	Predicted permease
MGAS2221_RS02620	COG2183	response to ionizing radiation
MGAS2221_RS02670	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS2221_RS02720	COG0386	Belongs to the glutathione peroxidase family
MGAS2221_RS02725	COG1164	Oligoendopeptidase f
MGAS2221_RS02735	COG0772	Belongs to the SEDS family
MGAS2221_RS02765	COG1078	dGTPase activity
MGAS2221_RS02780	COG1609	Transcriptional regulator
MGAS2221_RS02790	COG3716	PTS system mannose fructose sorbose family IID component
MGAS2221_RS02795	COG3715	PTS system
MGAS2221_RS02800	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS2221_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS2221_RS02830	COG0800	Aldolase
MGAS2221_RS02835	COG0546	phosphoglycolate phosphatase activity
MGAS2221_RS02840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS2221_RS02850	COG2884	Cell division ATP-binding protein ftsE
MGAS2221_RS02855	COG2177	Part of the ABC transporter FtsEX involved in
MGAS2221_RS02875	COG1199	ATP-dependent helicase activity
MGAS2221_RS02875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS2221_RS02880	COG0436	Aminotransferase
MGAS2221_RS02915	COG2188	Transcriptional regulator
MGAS2221_RS02920	COG2222	sugar isomerase
MGAS2221_RS02930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS2221_RS02935	COG0716	FMN binding
MGAS2221_RS02945	COG0038	chloride channel
MGAS2221_RS03040	COG1131	(ABC) transporter
MGAS2221_RS03060	COG4708	membrane
MGAS2221_RS03070	COG1597	lipid kinase activity
MGAS2221_RS03155	COG0577	efflux transmembrane transporter activity
MGAS2221_RS03165	COG2321	neutral zinc metallopeptidase
MGAS2221_RS03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS2221_RS03190	COG1970	mechanosensitive ion channel activity
MGAS2221_RS03195	COG0358	DNA primase activity
MGAS2221_RS03200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS2221_RS03205	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS2221_RS03250	COG1216	Glycosyl transferase, family 2
MGAS2221_RS03310	COG1368	sulfuric ester hydrolase activity
MGAS2221_RS03315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS2221_RS03335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS2221_RS03340	COG0285	dihydrofolate synthase activity
MGAS2221_RS03350	COG1104	cysteine desulfurase activity
MGAS2221_RS03375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS2221_RS03380	COG0583	DNA-binding transcription factor activity
MGAS2221_RS03390	COG0564	pseudouridine synthase activity
MGAS2221_RS03420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS2221_RS03425	COG1136	(ABC) transporter
MGAS2221_RS03430	COG0577	efflux transmembrane transporter activity
MGAS2221_RS03435	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS2221_RS03445	COG1837	Belongs to the UPF0109 family
MGAS2221_RS03495	COG1349	DNA-binding transcription factor activity
MGAS2221_RS03500	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS2221_RS03505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS2221_RS03505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS2221_RS03505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS2221_RS03510	COG1388	LysM domain
MGAS2221_RS03510	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS2221_RS03515	COG1388	LysM domain
MGAS2221_RS03515	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS2221_RS03555	COG0488	(ABC) transporter
MGAS2221_RS03565	COG0242	peptide deformylase activity
MGAS2221_RS03570	COG0737	Belongs to the 5'-nucleotidase family
MGAS2221_RS03575	COG2357	RelA SpoT domain protein
MGAS2221_RS03580	COG0745	RESPONSE REGULATOR receiver
MGAS2221_RS03615	COG3425	synthase
MGAS2221_RS03625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS2221_RS03685	COG0583	DNA-binding transcription factor activity
MGAS2221_RS03710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS2221_RS03715	COG0765	amino acid transport
MGAS2221_RS03735	COG0187	DNA topoisomerase II activity
MGAS2221_RS03745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS2221_RS03765	COG0539	negative regulation of cytoplasmic translation
MGAS2221_RS03810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS2221_RS03815	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS2221_RS03825	COG0300	oxidoreductase activity
MGAS2221_RS03830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS2221_RS03830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS2221_RS03845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS2221_RS03850	COG2384	SAM-dependent methyltransferase
MGAS2221_RS03860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS2221_RS03865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS2221_RS03875	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS2221_RS03880	COG1051	belongs to the nudix hydrolase family
MGAS2221_RS03885	COG0628	permease
MGAS2221_RS03890	COG0457	Tetratricopeptide repeat
MGAS2221_RS03895	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS2221_RS03910	COG1129	ABC transporter
MGAS2221_RS03930	COG0488	(ABC) transporter
MGAS2221_RS03935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS2221_RS03940	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS2221_RS03940	COG0022	dehydrogenase e1 component
MGAS2221_RS03965	COG5492	domain, Protein
MGAS2221_RS03970	COG0095	Lipoate-protein ligase
MGAS2221_RS03975	COG3442	glutamine amidotransferase
MGAS2221_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS2221_RS03985	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS2221_RS04005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS2221_RS04015	COG0647	UMP catabolic process
MGAS2221_RS04030	COG1518	maintenance of DNA repeat elements
MGAS2221_RS04035	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS2221_RS04080	COG3715	PTS system
MGAS2221_RS04085	COG3716	PTS system mannose fructose sorbose family IID component
MGAS2221_RS04090	COG2972	Histidine kinase
MGAS2221_RS04095	COG4753	response regulator
MGAS2221_RS04095	COG2207	Transcriptional regulator
MGAS2221_RS04100	COG1840	ABC-type Fe3 transport system, periplasmic component
MGAS2221_RS04115	COG1011	Hydrolase
MGAS2221_RS04120	COG1012	belongs to the aldehyde dehydrogenase family
MGAS2221_RS04135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS2221_RS04200	COG1131	(ABC) transporter
MGAS2221_RS04215	COG1396	sequence-specific DNA binding
MGAS2221_RS04245	COG0285	dihydrofolate synthase activity
MGAS2221_RS04265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS2221_RS04280	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS2221_RS04285	COG1177	transmembrane transport
MGAS2221_RS04295	COG4565	transcriptional regulatory protein
MGAS2221_RS04300	COG3290	protein histidine kinase activity
MGAS2221_RS04305	COG3493	citrate carrier protein
MGAS2221_RS04320	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS2221_RS04325	COG0038	chloride channel
MGAS2221_RS04335	COG0628	permease
MGAS2221_RS04345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS2221_RS04360	COG1104	cysteine desulfurase activity
MGAS2221_RS04375	COG2357	RelA SpoT domain protein
MGAS2221_RS04385	COG0564	pseudouridine synthase activity
MGAS2221_RS04390	COG0280	phosphate acetyltransferase
MGAS2221_RS04410	COG1174	glycine betaine transport
MGAS2221_RS04425	COG2233	PERMEase
MGAS2221_RS04450	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS2221_RS04480	COG1132	(ABC) transporter
MGAS2221_RS04485	COG1132	(ABC) transporter
MGAS2221_RS04505	COG3764	Sortase (surface protein transpeptidase)
MGAS2221_RS04510	COG0346	lactoylglutathione lyase activity
MGAS2221_RS04525	COG1272	protein, Hemolysin III
MGAS2221_RS04545	COG0758	DNA mediated transformation
MGAS2221_RS04550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS2221_RS04595	COG0511	ligase activity, forming carbon-carbon bonds
MGAS2221_RS04600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS2221_RS04615	COG2851	Citrate transporter
MGAS2221_RS04625	COG0511	ligase activity, forming carbon-carbon bonds
MGAS2221_RS04630	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS2221_RS04660	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS2221_RS04680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS2221_RS04690	COG2188	Transcriptional regulator
MGAS2221_RS04710	COG0488	(ABC) transporter
MGAS2221_RS04720	COG0352	thiamine-phosphate diphosphorylase activity
MGAS2221_RS04720	COG0351	phosphomethylpyrimidine kinase
MGAS2221_RS04725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS2221_RS04730	COG1328	CTP reductase activity
MGAS2221_RS04730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS2221_RS04735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS2221_RS04765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS2221_RS04785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS2221_RS04790	COG4684	Psort location CytoplasmicMembrane, score
MGAS2221_RS04795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS2221_RS04815	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS2221_RS04820	COG0295	cytidine deaminase activity
MGAS2221_RS04825	COG2813	Specifically methylates the guanine in position
MGAS2221_RS04840	COG5002	protein histidine kinase activity
MGAS2221_RS04845	COG0745	RESPONSE REGULATOR receiver
MGAS2221_RS04855	COG0704	Plays a role in the regulation of phosphate uptake
MGAS2221_RS04870	COG0581	inorganic phosphate transmembrane transporter activity
MGAS2221_RS04875	COG0573	inorganic phosphate transmembrane transporter activity
MGAS2221_RS04885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS2221_RS04885	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS2221_RS04890	COG0483	inositol monophosphate 1-phosphatase activity
MGAS2221_RS04905	COG0196	riboflavin kinase activity
MGAS2221_RS04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS2221_RS04935	COG1136	(ABC) transporter
MGAS2221_RS04985	COG1115	amino acid carrier protein
MGAS2221_RS04990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS2221_RS05000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS2221_RS05005	COG1126	abc transporter atp-binding protein
MGAS2221_RS05010	COG0765	amino acid transport
MGAS2221_RS05015	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS2221_RS05030	COG0469	pyruvate kinase activity
MGAS2221_RS05045	COG1725	Transcriptional regulator
MGAS2221_RS05050	COG1131	(ABC) transporter
MGAS2221_RS05205	COG1783	phage Terminase large subunit
MGAS2221_RS05310	COG1396	sequence-specific DNA binding
MGAS2221_RS05355	COG0058	SHG alpha-glucan phosphorylase activity
MGAS2221_RS05360	COG1640	4-alpha-glucanotransferase
MGAS2221_RS05365	COG1609	Transcriptional regulator
MGAS2221_RS05370	COG2182	Extracellular solute-binding protein
MGAS2221_RS05375	COG1175	transmembrane transport
MGAS2221_RS05380	COG3833	ABC-type maltose transport systems, permease component
MGAS2221_RS05395	COG3833	ABC-type maltose transport systems, permease component
MGAS2221_RS05400	COG1175	transmembrane transport
MGAS2221_RS05410	COG0366	Alpha amylase catalytic
MGAS2221_RS05415	COG2182	Extracellular solute-binding protein
MGAS2221_RS05420	COG0657	acetylesterase activity
MGAS2221_RS05425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS2221_RS05435	COG1696	Membrane protein involved in D-alanine export
MGAS2221_RS05455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS2221_RS05460	COG1126	abc transporter atp-binding protein
MGAS2221_RS05470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS2221_RS05480	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS2221_RS05490	COG3711	transcriptional antiterminator
MGAS2221_RS05490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS2221_RS05500	COG2723	6-phospho-beta-galactosidase activity
MGAS2221_RS05530	COG1187	pseudouridine synthase activity
MGAS2221_RS05540	COG2814	Major facilitator Superfamily
MGAS2221_RS05590	COG4109	DRTGG domain
MGAS2221_RS05595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MGAS2221_RS05620	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS2221_RS05620	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS2221_RS05630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS2221_RS05635	COG1956	GAF domain-containing protein
MGAS2221_RS05655	COG0513	Belongs to the DEAD box helicase family
MGAS2221_RS05660	COG0726	polysaccharide deacetylase
MGAS2221_RS05680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS2221_RS05685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS2221_RS05690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS2221_RS05720	COG1476	TRANSCRIPTIONal
MGAS2221_RS05735	COG4122	O-methyltransferase activity
MGAS2221_RS05740	COG2223	nitrite transmembrane transporter activity
MGAS2221_RS05755	COG1187	pseudouridine synthase activity
MGAS2221_RS05800	COG0658	competence protein
MGAS2221_RS05800	COG2333	competence protein COMEC
MGAS2221_RS05805	COG1596	polysaccharide export
MGAS2221_RS05805	COG1555	photosystem II stabilization
MGAS2221_RS05810	COG0204	Acyl-transferase
MGAS2221_RS05815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS2221_RS05830	COG0513	Belongs to the DEAD box helicase family
MGAS2221_RS05845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS2221_RS05860	COG0768	penicillin binding
MGAS2221_RS05865	COG2116	formate transmembrane transporter activity
MGAS2221_RS05875	COG1827	regulation of RNA biosynthetic process
MGAS2221_RS05890	COG2217	Heavy metal translocating P-type atpase
MGAS2221_RS06075	COG3723	Recombinational DNA repair protein, rece pathway
MGAS2221_RS06100	COG3935	DnaD domain protein
MGAS2221_RS06135	COG3561	AntA/AntB antirepressor
MGAS2221_RS06150	COG1396	sequence-specific DNA binding
MGAS2221_RS06165	COG0582	viral genome integration into host DNA
MGAS2221_RS06180	COG2755	lipolytic protein G-D-S-L family
MGAS2221_RS06195	COG0497	DNA recombination
MGAS2221_RS06200	COG1438	arginine binding
MGAS2221_RS06205	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS2221_RS06230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS2221_RS06245	COG0765	amino acid transport
MGAS2221_RS06250	COG4703	Protein of unknown function (DUF1797)
MGAS2221_RS06255	COG0542	response to heat
MGAS2221_RS06260	COG0494	nUDIX hydrolase
MGAS2221_RS06275	COG3599	regulation of cell shape
MGAS2221_RS06280	COG2302	S4 RNA-binding domain
MGAS2221_RS06295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS2221_RS06335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS2221_RS06340	COG1940	carbohydrate kinase activity
MGAS2221_RS06350	COG0783	Belongs to the Dps family
MGAS2221_RS06365	COG4470	Protein conserved in bacteria
MGAS2221_RS06375	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS2221_RS06385	COG0742	ribosomal rna small subunit methyltransferase
MGAS2221_RS06395	COG0549	Belongs to the carbamate kinase family
MGAS2221_RS06400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS2221_RS06405	COG1288	antiporter activity
MGAS2221_RS06420	COG2235	arginine
MGAS2221_RS06445	COG2972	Histidine kinase
MGAS2221_RS06460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS2221_RS06465	COG0785	Cytochrome C biogenesis protein
MGAS2221_RS06470	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS2221_RS06475	COG1518	maintenance of DNA repeat elements
MGAS2221_RS06535	COG1605	Chorismate mutase
MGAS2221_RS06535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS2221_RS06555	COG2226	methyltransferase
MGAS2221_RS06565	COG3250	beta-galactosidase activity
MGAS2221_RS06570	COG4753	response regulator
MGAS2221_RS06570	COG2207	Transcriptional regulator
MGAS2221_RS06575	COG2972	Histidine kinase
MGAS2221_RS06590	COG0395	ABC-type sugar transport system, permease component
MGAS2221_RS06595	COG1175	transmembrane transport
MGAS2221_RS06600	COG1940	carbohydrate kinase activity
MGAS2221_RS06605	COG2723	6-phospho-beta-galactosidase activity
MGAS2221_RS06610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS2221_RS06625	COG0383	alpha-mannosidase activity
MGAS2221_RS06720	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS2221_RS06725	COG1739	Uncharacterized protein family UPF0029
MGAS2221_RS06735	COG1098	S1 RNA binding domain
MGAS2221_RS06745	COG2197	response regulator
MGAS2221_RS06750	COG4585	Histidine kinase
MGAS2221_RS06760	COG2815	serine threonine protein kinase
MGAS2221_RS06760	COG0515	serine threonine protein kinase
MGAS2221_RS06770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS2221_RS06770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS2221_RS06780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS2221_RS06800	COG0583	DNA-binding transcription factor activity
MGAS2221_RS06805	COG0183	Belongs to the thiolase family
MGAS2221_RS06810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS2221_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS2221_RS06825	COG2610	gluconate transmembrane transporter activity
MGAS2221_RS06840	COG0116	Belongs to the methyltransferase superfamily
MGAS2221_RS06865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS2221_RS06870	COG3579	cysteine-type endopeptidase activity
MGAS2221_RS06880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS2221_RS06885	COG1113	amino acid transport
MGAS2221_RS06890	COG0492	ferredoxin-NADP+ reductase activity
MGAS2221_RS06900	COG1126	abc transporter atp-binding protein
MGAS2221_RS06910	COG0513	Belongs to the DEAD box helicase family
MGAS2221_RS06920	COG0768	penicillin binding
MGAS2221_RS06955	COG1131	(ABC) transporter
MGAS2221_RS06980	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS2221_RS06985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS2221_RS07020	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS2221_RS07025	COG0656	L-ascorbic acid biosynthetic process
MGAS2221_RS07035	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS2221_RS07055	COG0561	phosphatase activity
MGAS2221_RS07060	COG2860	membrane
MGAS2221_RS07115	COG2217	Heavy metal translocating P-type atpase
MGAS2221_RS07145	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS2221_RS07150	COG0195	Participates in both transcription termination and antitermination
MGAS2221_RS07170	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS2221_RS07290	COG1783	phage Terminase large subunit
MGAS2221_RS07420	COG4974	Belongs to the 'phage' integrase family
MGAS2221_RS07440	COG4473	ABC transporter
MGAS2221_RS07445	COG1131	(ABC) transporter
MGAS2221_RS07450	COG0537	adenosine 5'-monophosphoramidase activity
MGAS2221_RS07460	COG1316	TRANSCRIPTIONal
MGAS2221_RS07470	COG0802	atpase or kinase
MGAS2221_RS07475	COG2252	PERMEase
MGAS2221_RS07480	COG0561	phosphatase activity
MGAS2221_RS07490	COG3715	PTS system
MGAS2221_RS07495	COG3716	PTS system mannose fructose sorbose family IID component
MGAS2221_RS07520	COG0439	Biotin carboxylase
MGAS2221_RS07535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS2221_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS2221_RS07545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS2221_RS07570	COG1024	Enoyl-CoA hydratase
MGAS2221_RS07605	COG0588	phosphoglycerate mutase activity
MGAS2221_RS07610	COG2261	transglycosylase associated protein
MGAS2221_RS07640	COG1335	isochorismatase
MGAS2221_RS07650	COG0436	Aminotransferase
MGAS2221_RS07660	COG0561	phosphatase activity
MGAS2221_RS07665	COG0252	asparaginase activity
MGAS2221_RS07680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS2221_RS07685	COG1129	ABC transporter
MGAS2221_RS07700	COG1132	(ABC) transporter
MGAS2221_RS07705	COG4988	ABC transporter
MGAS2221_RS07710	COG1120	ATPase activity
MGAS2221_RS07735	COG1388	LysM domain
MGAS2221_RS07735	COG3942	CHAP domain
MGAS2221_RS07755	COG5433	transposase activity
MGAS2221_RS07760	COG1482	cell wall glycoprotein biosynthetic process
MGAS2221_RS07765	COG1940	carbohydrate kinase activity
MGAS2221_RS07775	COG2190	(PTS) system
MGAS2221_RS07775	COG1263	PTS System
MGAS2221_RS07775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS2221_RS07780	COG1621	beta-fructofuranosidase activity
MGAS2221_RS07785	COG1609	Transcriptional regulator
MGAS2221_RS07805	COG2131	deaminase
MGAS2221_RS07810	COG0006	proline dipeptidase activity
MGAS2221_RS07850	COG1194	a g-specific adenine glycosylase
MGAS2221_RS07860	COG3118	belongs to the thioredoxin family
MGAS2221_RS07890	COG0681	Belongs to the peptidase S26 family
MGAS2221_RS07895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS2221_RS07910	COG1882	Formate acetyltransferase
MGAS2221_RS07915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS2221_RS07930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS2221_RS07940	COG2814	Major facilitator Superfamily
MGAS2221_RS07945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS2221_RS07970	COG0789	Transcriptional regulator
MGAS2221_RS07985	COG2081	HI0933 family
MGAS2221_RS07995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS2221_RS08000	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS2221_RS08020	COG0456	acetyltransferase
MGAS2221_RS08025	COG1214	PFAM Peptidase M22, glycoprotease
MGAS2221_RS08040	COG0174	glutamine synthetase
MGAS2221_RS08045	COG0789	Transcriptional regulator
MGAS2221_RS08060	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS2221_RS08080	COG5433	transposase activity
MGAS2221_RS08120	COG0668	transmembrane transport
MGAS2221_RS08130	COG4720	Psort location CytoplasmicMembrane, score
MGAS2221_RS08135	COG0351	phosphomethylpyrimidine kinase
MGAS2221_RS08180	COG2801	Transposase and inactivated derivatives
MGAS2221_RS08190	COG0444	Belongs to the ABC transporter superfamily
MGAS2221_RS08195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS2221_RS08200	COG0601	transmembrane transport
MGAS2221_RS08205	COG4166	transmembrane transport
MGAS2221_RS08210	COG1686	Belongs to the peptidase S11 family
MGAS2221_RS08215	COG1686	Belongs to the peptidase S11 family
MGAS2221_RS08230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS2221_RS08235	COG0719	Fe-S assembly protein
MGAS2221_RS08245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS2221_RS08265	COG0765	amino acid transport
MGAS2221_RS08305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS2221_RS08320	COG1564	THIamine pyrophosphokinase
MGAS2221_RS08345	COG0084	hydrolase, TatD family'
MGAS2221_RS08360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS2221_RS08370	COG0395	ABC-type sugar transport system, permease component
MGAS2221_RS08375	COG1175	transmembrane transport
MGAS2221_RS08395	COG1847	R3H domain protein
MGAS2221_RS08420	COG3290	protein histidine kinase activity
MGAS2221_RS08445	COG0756	dUTP diphosphatase activity
MGAS2221_RS08455	COG1132	(ABC) transporter
MGAS2221_RS08460	COG1132	(ABC) transporter
MGAS2221_RS08480	COG0457	Tetratricopeptide repeat
MGAS2221_RS08480	COG0705	Rhomboid family
MGAS2221_RS08485	COG5433	transposase activity
MGAS2221_RS08515	COG3711	transcriptional antiterminator
MGAS2221_RS08525	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS2221_RS08525	COG3942	CHAP domain
MGAS2221_RS08530	COG2205	protein histidine kinase activity
MGAS2221_RS08535	COG0745	RESPONSE REGULATOR receiver
MGAS2221_RS08540	COG0577	efflux transmembrane transporter activity
MGAS2221_RS08545	COG1136	(ABC) transporter
MGAS2221_RS08600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS2221_RS08615	COG1882	Formate acetyltransferase
MGAS2221_RS08620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS2221_RS08625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS2221_RS08630	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS2221_RS08635	COG2390	Transcriptional regulator
MGAS2221_RS08640	COG1349	DNA-binding transcription factor activity
MGAS2221_RS08645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS2221_RS08665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS2221_RS08680	COG0564	pseudouridine synthase activity
MGAS2221_RS08710	COG0542	response to heat
MGAS2221_RS08715	COG4463	regulation of RNA biosynthetic process
MGAS2221_RS08730	COG0450	alkyl hydroperoxide reductase
MGAS2221_RS08745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS2221_RS08755	COG3404	Formiminotransferase-cyclodeaminase
MGAS2221_RS08770	COG0531	amino acid
MGAS2221_RS08800	COG3590	peptidase
MGAS2221_RS08805	COG0366	Alpha amylase catalytic
MGAS2221_RS08810	COG1263	PTS System
MGAS2221_RS08810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS2221_RS08815	COG2188	Transcriptional regulator
MGAS2221_RS08820	COG1733	regulation of RNA biosynthetic process
MGAS2221_RS08825	COG2514	catechol 2,3-dioxygenase activity
MGAS2221_RS08835	COG0602	queuosine metabolic process
MGAS2221_RS08855	COG1328	CTP reductase activity
MGAS2221_RS08880	COG1393	Belongs to the ArsC family
MGAS2221_RS08895	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS2221_RS08905	COG2814	Major facilitator Superfamily
MGAS2221_RS08940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS2221_RS08945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS2221_RS08950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS2221_RS09035	COG1511	domain protein
MGAS2221_RS09050	COG5433	transposase activity
MGAS2221_RS09060	COG0305	Participates in initiation and elongation during chromosome replication
MGAS2221_RS09090	COG1760	l-serine dehydratase
MGAS2221_RS09095	COG1760	l-serine dehydratase
MGAS2221_RS09100	COG0741	lytic transglycosylase activity
MGAS2221_RS09105	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS2221_RS09120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS2221_RS09130	COG0612	Peptidase, M16
MGAS2221_RS09140	COG1215	transferase activity, transferring glycosyl groups
MGAS2221_RS09170	COG0516	GMP reductase activity
MGAS2221_RS09170	COG0517	IMP dehydrogenase activity
MGAS2221_RS09180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS2221_RS09185	COG0488	(ABC) transporter
MGAS2221_RS09220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS2221_RS09225	COG1475	DNA binding