locus-tag	class	description
MGAS23530_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS23530_RS00020	COG0012	GTP binding
MGAS23530_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS23530_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS23530_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS23530_RS00065	COG0531	amino acid
MGAS23530_RS00175	COG3942	CHAP domain
MGAS23530_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS23530_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS23530_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS23530_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS23530_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS23530_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS23530_RS00285	COG1454	alcohol dehydrogenase
MGAS23530_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
MGAS23530_RS00290	COG1064	alcohol dehydrogenase
MGAS23530_RS00295	COG0534	Mate efflux family protein
MGAS23530_RS00405	COG0201	protein transport
MGAS23530_RS00540	COG1121	(ABC) transporter
MGAS23530_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS23530_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS23530_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS23530_RS00585	COG1459	type II secretion system
MGAS23530_RS00590	COG4537	Required for transformation and DNA binding
MGAS23530_RS00625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS23530_RS00630	COG1363	Peptidase, m42
MGAS23530_RS00640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS23530_RS00645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS23530_RS00655	COG1428	Deoxynucleoside kinase
MGAS23530_RS00660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS23530_RS00700	COG4509	Sortase family
MGAS23530_RS00725	COG2031	fatty acid transporter
MGAS23530_RS00740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS23530_RS00755	COG0251	oxidation-reduction process
MGAS23530_RS00770	COG1269	ATP hydrolysis coupled proton transport
MGAS23530_RS00775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS23530_RS00785	COG1527	subunit (C
MGAS23530_RS00790	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS23530_RS00825	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS23530_RS00865	COG0626	cystathionine gamma-synthase activity
MGAS23530_RS00895	COG3623	hexulose-6-phosphate isomerase
MGAS23530_RS00915	COG3448	diguanylate cyclase activity
MGAS23530_RS00915	COG4175	Glycine betaine
MGAS23530_RS00925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS23530_RS00925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS23530_RS00950	COG1268	BioY protein
MGAS23530_RS00955	COG1234	tRNA 3'-trailer cleavage
MGAS23530_RS00990	COG0705	Rhomboid family
MGAS23530_RS00990	COG0457	Tetratricopeptide repeat
MGAS23530_RS01010	COG1132	(ABC) transporter
MGAS23530_RS01015	COG1132	(ABC) transporter
MGAS23530_RS01025	COG0756	dUTP diphosphatase activity
MGAS23530_RS01055	COG3290	protein histidine kinase activity
MGAS23530_RS01080	COG1847	R3H domain protein
MGAS23530_RS01100	COG1175	transmembrane transport
MGAS23530_RS01105	COG0395	ABC-type sugar transport system, permease component
MGAS23530_RS01120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS23530_RS01135	COG0084	hydrolase, TatD family'
MGAS23530_RS01160	COG1564	THIamine pyrophosphokinase
MGAS23530_RS01175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS23530_RS01200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MGAS23530_RS01210	COG0765	amino acid transport
MGAS23530_RS01230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS23530_RS01240	COG0719	Fe-S assembly protein
MGAS23530_RS01245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS23530_RS01260	COG1686	Belongs to the peptidase S11 family
MGAS23530_RS01265	COG1686	Belongs to the peptidase S11 family
MGAS23530_RS01270	COG4166	transmembrane transport
MGAS23530_RS01275	COG0601	transmembrane transport
MGAS23530_RS01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS23530_RS01285	COG0444	Belongs to the ABC transporter superfamily
MGAS23530_RS01335	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS23530_RS01340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS23530_RS01345	COG1534	Rna-binding protein
MGAS23530_RS01355	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS23530_RS01360	COG0799	negative regulation of ribosome biogenesis
MGAS23530_RS01365	COG2226	methyltransferase
MGAS23530_RS01380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS23530_RS01385	COG1464	Belongs to the NlpA lipoprotein family
MGAS23530_RS01400	COG1114	Component of the transport system for branched-chain amino acids
MGAS23530_RS01410	COG0569	domain protein
MGAS23530_RS01415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS23530_RS01425	COG1704	LemA family
MGAS23530_RS01440	COG0745	RESPONSE REGULATOR receiver
MGAS23530_RS01460	COG1484	DNA-dependent DNA replication
MGAS23530_RS01470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS23530_RS01490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS23530_RS01505	COG1254	Belongs to the acylphosphatase family
MGAS23530_RS01510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS23530_RS01565	COG1187	pseudouridine synthase activity
MGAS23530_RS01580	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS23530_RS01585	COG0671	phosphoesterase, PA-phosphatase related
MGAS23530_RS01590	COG1242	4 iron, 4 sulfur cluster binding
MGAS23530_RS01595	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS23530_RS01600	COG1253	flavin adenine dinucleotide binding
MGAS23530_RS01605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS23530_RS01620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS23530_RS01625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS23530_RS01630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS23530_RS01635	COG1120	ATPase activity
MGAS23530_RS01645	COG2244	polysaccharide biosynthetic process
MGAS23530_RS01670	COG0470	DNA polymerase III
MGAS23530_RS01695	COG1393	Belongs to the ArsC family
MGAS23530_RS01700	COG0708	Exodeoxyribonuclease III
MGAS23530_RS01710	COG1304	FMN binding
MGAS23530_RS01815	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS23530_RS01820	COG0673	inositol 2-dehydrogenase activity
MGAS23530_RS01835	COG0494	nUDIX hydrolase
MGAS23530_RS01845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS23530_RS01890	COG5433	transposase activity
MGAS23530_RS01945	COG1702	phosphate starvation-inducible protein PhoH
MGAS23530_RS01950	COG1573	uracil-dna glycosylase
MGAS23530_RS01960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS23530_RS01990	COG3328	transposase activity
MGAS23530_RS01995	COG3328	transposase activity
MGAS23530_RS02050	COG0433	COG0433 Predicted ATPase
MGAS23530_RS02055	COG2814	Major facilitator Superfamily
MGAS23530_RS02065	COG0557	exoribonuclease II activity
MGAS23530_RS02095	COG0463	Glycosyl transferase, family 2
MGAS23530_RS02105	COG0778	Nitroreductase
MGAS23530_RS02110	COG0006	proline dipeptidase activity
MGAS23530_RS02115	COG1609	Transcriptional regulator
MGAS23530_RS02125	COG0438	transferase activity, transferring glycosyl groups
MGAS23530_RS02135	COG4555	ABC transporter
MGAS23530_RS02155	COG0183	Belongs to the thiolase family
MGAS23530_RS02170	COG0745	RESPONSE REGULATOR receiver
MGAS23530_RS02175	COG5002	protein histidine kinase activity
MGAS23530_RS02180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS23530_RS02190	COG1196	nuclear chromosome segregation
MGAS23530_RS02200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS23530_RS02285	COG4695	Portal protein
MGAS23530_RS02295	COG0561	phosphatase activity
MGAS23530_RS02300	COG0561	phosphatase activity
MGAS23530_RS02305	COG0552	protein localization to endoplasmic reticulum
MGAS23530_RS02310	COG0477	Major facilitator Superfamily
MGAS23530_RS02315	COG3711	transcriptional antiterminator
MGAS23530_RS02320	COG1263	PTS System
MGAS23530_RS02320	COG2190	(PTS) system
MGAS23530_RS02320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS23530_RS02330	COG3689	TIGRFAM TIGR03943 family protein
MGAS23530_RS02335	COG0701	Predicted permease
MGAS23530_RS02340	COG2183	response to ionizing radiation
MGAS23530_RS02385	COG0826	peptidase U32
MGAS23530_RS02390	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS23530_RS02435	COG0386	Belongs to the glutathione peroxidase family
MGAS23530_RS02440	COG1164	Oligoendopeptidase f
MGAS23530_RS02450	COG0772	Belongs to the SEDS family
MGAS23530_RS02485	COG1078	dGTPase activity
MGAS23530_RS02500	COG1609	Transcriptional regulator
MGAS23530_RS02510	COG3716	PTS system mannose fructose sorbose family IID component
MGAS23530_RS02515	COG3715	PTS system
MGAS23530_RS02520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS23530_RS02535	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS23530_RS02560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS23530_RS02570	COG2884	Cell division ATP-binding protein ftsE
MGAS23530_RS02575	COG2177	Part of the ABC transporter FtsEX involved in
MGAS23530_RS02590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS23530_RS02590	COG1199	ATP-dependent helicase activity
MGAS23530_RS02595	COG0436	Aminotransferase
MGAS23530_RS02630	COG2188	Transcriptional regulator
MGAS23530_RS02635	COG2222	sugar isomerase
MGAS23530_RS02645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS23530_RS02650	COG0716	FMN binding
MGAS23530_RS02660	COG0038	chloride channel
MGAS23530_RS02730	COG1131	(ABC) transporter
MGAS23530_RS02750	COG4708	membrane
MGAS23530_RS02760	COG1597	lipid kinase activity
MGAS23530_RS02845	COG0577	efflux transmembrane transporter activity
MGAS23530_RS02850	COG1136	(ABC) transporter
MGAS23530_RS02855	COG2321	neutral zinc metallopeptidase
MGAS23530_RS02870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS23530_RS02880	COG1970	mechanosensitive ion channel activity
MGAS23530_RS02885	COG0358	DNA primase activity
MGAS23530_RS02890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS23530_RS02895	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS23530_RS02940	COG1216	Glycosyl transferase, family 2
MGAS23530_RS02995	COG1368	sulfuric ester hydrolase activity
MGAS23530_RS03000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS23530_RS03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS23530_RS03025	COG0285	dihydrofolate synthase activity
MGAS23530_RS03035	COG1104	cysteine desulfurase activity
MGAS23530_RS03060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS23530_RS03065	COG0583	DNA-binding transcription factor activity
MGAS23530_RS03075	COG0564	pseudouridine synthase activity
MGAS23530_RS03105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS23530_RS03110	COG1136	(ABC) transporter
MGAS23530_RS03115	COG0577	efflux transmembrane transporter activity
MGAS23530_RS03120	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS23530_RS03130	COG1837	Belongs to the UPF0109 family
MGAS23530_RS03180	COG1349	DNA-binding transcription factor activity
MGAS23530_RS03185	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS23530_RS03190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS23530_RS03190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS23530_RS03190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS23530_RS03195	COG1388	LysM domain
MGAS23530_RS03195	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS23530_RS03200	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS23530_RS03200	COG1388	LysM domain
MGAS23530_RS03220	COG0105	UTP biosynthetic process
MGAS23530_RS03240	COG0488	(ABC) transporter
MGAS23530_RS03250	COG0242	peptide deformylase activity
MGAS23530_RS03260	COG2357	RelA SpoT domain protein
MGAS23530_RS03265	COG0745	RESPONSE REGULATOR receiver
MGAS23530_RS03300	COG3425	synthase
MGAS23530_RS03310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS23530_RS03365	COG0583	DNA-binding transcription factor activity
MGAS23530_RS03390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS23530_RS03395	COG0765	amino acid transport
MGAS23530_RS03415	COG0187	DNA topoisomerase II activity
MGAS23530_RS03425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS23530_RS03445	COG0539	negative regulation of cytoplasmic translation
MGAS23530_RS03480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS23530_RS03485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS23530_RS03495	COG0300	oxidoreductase activity
MGAS23530_RS03500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS23530_RS03500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS23530_RS03515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS23530_RS03520	COG2384	SAM-dependent methyltransferase
MGAS23530_RS03530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS23530_RS03535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS23530_RS03545	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS23530_RS03550	COG1051	belongs to the nudix hydrolase family
MGAS23530_RS03555	COG0628	permease
MGAS23530_RS03560	COG0457	Tetratricopeptide repeat
MGAS23530_RS03565	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS23530_RS03580	COG1129	ABC transporter
MGAS23530_RS03600	COG0488	(ABC) transporter
MGAS23530_RS03605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS23530_RS03610	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS23530_RS03610	COG0022	dehydrogenase e1 component
MGAS23530_RS03615	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS23530_RS03630	COG5492	domain, Protein
MGAS23530_RS03635	COG0095	Lipoate-protein ligase
MGAS23530_RS03640	COG3442	glutamine amidotransferase
MGAS23530_RS03645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS23530_RS03650	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS23530_RS03670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS23530_RS03680	COG0647	UMP catabolic process
MGAS23530_RS03695	COG1518	maintenance of DNA repeat elements
MGAS23530_RS03700	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS23530_RS03715	COG0105	UTP biosynthetic process
MGAS23530_RS03750	COG3715	PTS system
MGAS23530_RS03755	COG3716	PTS system mannose fructose sorbose family IID component
MGAS23530_RS03760	COG2972	Histidine kinase
MGAS23530_RS03765	COG4753	response regulator
MGAS23530_RS03765	COG2207	Transcriptional regulator
MGAS23530_RS03775	COG1012	belongs to the aldehyde dehydrogenase family
MGAS23530_RS03790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS23530_RS03870	COG1131	(ABC) transporter
MGAS23530_RS03925	COG0285	dihydrofolate synthase activity
MGAS23530_RS03945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS23530_RS03960	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS23530_RS03965	COG1177	transmembrane transport
MGAS23530_RS03975	COG4565	transcriptional regulatory protein
MGAS23530_RS03980	COG3290	protein histidine kinase activity
MGAS23530_RS03985	COG0281	malic enzyme
MGAS23530_RS03995	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS23530_RS04000	COG0038	chloride channel
MGAS23530_RS04010	COG0628	permease
MGAS23530_RS04020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS23530_RS04035	COG1104	cysteine desulfurase activity
MGAS23530_RS04050	COG2357	RelA SpoT domain protein
MGAS23530_RS04060	COG0564	pseudouridine synthase activity
MGAS23530_RS04065	COG0280	phosphate acetyltransferase
MGAS23530_RS04070	COG4221	oxidoreductase activity
MGAS23530_RS04085	COG1174	glycine betaine transport
MGAS23530_RS04100	COG2233	PERMEase
MGAS23530_RS04125	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS23530_RS04155	COG1132	(ABC) transporter
MGAS23530_RS04160	COG1132	(ABC) transporter
MGAS23530_RS04180	COG3764	Sortase (surface protein transpeptidase)
MGAS23530_RS04185	COG0346	lactoylglutathione lyase activity
MGAS23530_RS04200	COG1272	protein, Hemolysin III
MGAS23530_RS04220	COG0758	DNA mediated transformation
MGAS23530_RS04225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS23530_RS04270	COG0511	ligase activity, forming carbon-carbon bonds
MGAS23530_RS04275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS23530_RS04290	COG2851	Citrate transporter
MGAS23530_RS04300	COG0511	ligase activity, forming carbon-carbon bonds
MGAS23530_RS04305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS23530_RS04335	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS23530_RS04355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS23530_RS04365	COG2188	Transcriptional regulator
MGAS23530_RS04385	COG0488	(ABC) transporter
MGAS23530_RS04395	COG0351	phosphomethylpyrimidine kinase
MGAS23530_RS04395	COG0352	thiamine-phosphate diphosphorylase activity
MGAS23530_RS04400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS23530_RS04405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS23530_RS04405	COG1328	CTP reductase activity
MGAS23530_RS04410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS23530_RS04440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS23530_RS04460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS23530_RS04465	COG4684	Psort location CytoplasmicMembrane, score
MGAS23530_RS04470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS23530_RS04475	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS23530_RS04480	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS23530_RS04485	COG3845	ABC transporter
MGAS23530_RS04490	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS23530_RS04495	COG0295	cytidine deaminase activity
MGAS23530_RS04500	COG2813	Specifically methylates the guanine in position
MGAS23530_RS04515	COG5002	protein histidine kinase activity
MGAS23530_RS04520	COG0745	RESPONSE REGULATOR receiver
MGAS23530_RS04530	COG0704	Plays a role in the regulation of phosphate uptake
MGAS23530_RS04545	COG0581	inorganic phosphate transmembrane transporter activity
MGAS23530_RS04550	COG0573	inorganic phosphate transmembrane transporter activity
MGAS23530_RS04560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS23530_RS04560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS23530_RS04565	COG0483	inositol monophosphate 1-phosphatase activity
MGAS23530_RS04580	COG0196	riboflavin kinase activity
MGAS23530_RS04610	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS23530_RS04610	COG1136	(ABC) transporter
MGAS23530_RS04660	COG1115	amino acid carrier protein
MGAS23530_RS04665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS23530_RS04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS23530_RS04680	COG1126	abc transporter atp-binding protein
MGAS23530_RS04685	COG0765	amino acid transport
MGAS23530_RS04690	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS23530_RS04705	COG0469	pyruvate kinase activity
MGAS23530_RS04720	COG1725	Transcriptional regulator
MGAS23530_RS04725	COG1131	(ABC) transporter
MGAS23530_RS04750	COG0058	SHG alpha-glucan phosphorylase activity
MGAS23530_RS04755	COG1640	4-alpha-glucanotransferase
MGAS23530_RS04760	COG1609	Transcriptional regulator
MGAS23530_RS04765	COG2182	Extracellular solute-binding protein
MGAS23530_RS04770	COG1175	transmembrane transport
MGAS23530_RS04775	COG3833	ABC-type maltose transport systems, permease component
MGAS23530_RS04790	COG3833	ABC-type maltose transport systems, permease component
MGAS23530_RS04795	COG1175	transmembrane transport
MGAS23530_RS04805	COG0366	Alpha amylase catalytic
MGAS23530_RS04810	COG2182	Extracellular solute-binding protein
MGAS23530_RS04820	COG0657	acetylesterase activity
MGAS23530_RS04825	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS23530_RS04835	COG1696	Membrane protein involved in D-alanine export
MGAS23530_RS04855	COG0765	amino acid transport
MGAS23530_RS04860	COG1126	abc transporter atp-binding protein
MGAS23530_RS04865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS23530_RS04875	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS23530_RS04885	COG3711	transcriptional antiterminator
MGAS23530_RS04885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS23530_RS04895	COG2723	6-phospho-beta-galactosidase activity
MGAS23530_RS04915	COG2801	Transposase and inactivated derivatives
MGAS23530_RS04920	COG1187	pseudouridine synthase activity
MGAS23530_RS04930	COG2814	Major facilitator Superfamily
MGAS23530_RS04980	COG4109	DRTGG domain
MGAS23530_RS05010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS23530_RS05010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS23530_RS05015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS23530_RS05020	COG1956	GAF domain-containing protein
MGAS23530_RS05040	COG0513	Belongs to the DEAD box helicase family
MGAS23530_RS05045	COG0726	polysaccharide deacetylase
MGAS23530_RS05065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS23530_RS05070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS23530_RS05075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS23530_RS05090	COG2801	Transposase and inactivated derivatives
MGAS23530_RS05095	COG2801	Transposase and inactivated derivatives
MGAS23530_RS05110	COG1476	TRANSCRIPTIONal
MGAS23530_RS05125	COG4122	O-methyltransferase activity
MGAS23530_RS05130	COG2223	nitrite transmembrane transporter activity
MGAS23530_RS05145	COG1187	pseudouridine synthase activity
MGAS23530_RS05190	COG2333	competence protein COMEC
MGAS23530_RS05190	COG0658	competence protein
MGAS23530_RS05195	COG1555	photosystem II stabilization
MGAS23530_RS05195	COG1596	polysaccharide export
MGAS23530_RS05200	COG0204	Acyl-transferase
MGAS23530_RS05205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS23530_RS05220	COG0513	Belongs to the DEAD box helicase family
MGAS23530_RS05235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS23530_RS05250	COG0768	penicillin binding
MGAS23530_RS05255	COG2116	formate transmembrane transporter activity
MGAS23530_RS05265	COG1827	regulation of RNA biosynthetic process
MGAS23530_RS05280	COG2217	Heavy metal translocating P-type atpase
MGAS23530_RS05295	COG2755	lipolytic protein G-D-S-L family
MGAS23530_RS05310	COG0497	DNA recombination
MGAS23530_RS05315	COG1438	arginine binding
MGAS23530_RS05320	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS23530_RS05345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS23530_RS05350	COG0415	Belongs to the DNA photolyase family
MGAS23530_RS05360	COG0765	amino acid transport
MGAS23530_RS05365	COG4703	Protein of unknown function (DUF1797)
MGAS23530_RS05370	COG0542	response to heat
MGAS23530_RS05375	COG0494	nUDIX hydrolase
MGAS23530_RS05390	COG3599	regulation of cell shape
MGAS23530_RS05395	COG2302	S4 RNA-binding domain
MGAS23530_RS05445	COG1217	gtp-binding protein TYPA
MGAS23530_RS05450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS23530_RS05455	COG1940	carbohydrate kinase activity
MGAS23530_RS05465	COG0783	Belongs to the Dps family
MGAS23530_RS05480	COG4470	Protein conserved in bacteria
MGAS23530_RS05485	COG1609	Transcriptional regulator
MGAS23530_RS05490	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS23530_RS05500	COG0742	ribosomal rna small subunit methyltransferase
MGAS23530_RS05510	COG0549	Belongs to the carbamate kinase family
MGAS23530_RS05515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS23530_RS05520	COG1288	antiporter activity
MGAS23530_RS05535	COG2235	arginine
MGAS23530_RS05560	COG2972	Histidine kinase
MGAS23530_RS05575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS23530_RS05580	COG0785	Cytochrome C biogenesis protein
MGAS23530_RS05585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS23530_RS05590	COG1518	maintenance of DNA repeat elements
MGAS23530_RS05650	COG5433	transposase activity
MGAS23530_RS05660	COG1605	Chorismate mutase
MGAS23530_RS05660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS23530_RS05680	COG2226	methyltransferase
MGAS23530_RS05690	COG3250	beta-galactosidase activity
MGAS23530_RS05695	COG2207	Transcriptional regulator
MGAS23530_RS05695	COG4753	response regulator
MGAS23530_RS05700	COG2972	Histidine kinase
MGAS23530_RS05710	COG1653	transport
MGAS23530_RS05715	COG0395	ABC-type sugar transport system, permease component
MGAS23530_RS05720	COG1175	transmembrane transport
MGAS23530_RS05725	COG1940	carbohydrate kinase activity
MGAS23530_RS05730	COG2723	6-phospho-beta-galactosidase activity
MGAS23530_RS05735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS23530_RS05750	COG0383	alpha-mannosidase activity
MGAS23530_RS05840	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS23530_RS05845	COG1739	Uncharacterized protein family UPF0029
MGAS23530_RS05855	COG1098	S1 RNA binding domain
MGAS23530_RS05865	COG2197	response regulator
MGAS23530_RS05870	COG4585	Histidine kinase
MGAS23530_RS05880	COG2815	serine threonine protein kinase
MGAS23530_RS05880	COG0515	serine threonine protein kinase
MGAS23530_RS05890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS23530_RS05890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS23530_RS05900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS23530_RS05920	COG0583	DNA-binding transcription factor activity
MGAS23530_RS05925	COG0183	Belongs to the thiolase family
MGAS23530_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS23530_RS05945	COG2610	gluconate transmembrane transporter activity
MGAS23530_RS05960	COG0116	Belongs to the methyltransferase superfamily
MGAS23530_RS05985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS23530_RS05990	COG3579	cysteine-type endopeptidase activity
MGAS23530_RS06000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS23530_RS06005	COG1113	amino acid transport
MGAS23530_RS06010	COG0492	ferredoxin-NADP+ reductase activity
MGAS23530_RS06020	COG1126	abc transporter atp-binding protein
MGAS23530_RS06030	COG0513	Belongs to the DEAD box helicase family
MGAS23530_RS06040	COG0768	penicillin binding
MGAS23530_RS06075	COG1131	(ABC) transporter
MGAS23530_RS06100	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS23530_RS06105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS23530_RS06140	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS23530_RS06145	COG0656	L-ascorbic acid biosynthetic process
MGAS23530_RS06155	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS23530_RS06175	COG0561	phosphatase activity
MGAS23530_RS06180	COG2860	membrane
MGAS23530_RS06230	COG2217	Heavy metal translocating P-type atpase
MGAS23530_RS06260	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS23530_RS06265	COG0195	Participates in both transcription termination and antitermination
MGAS23530_RS06290	COG4473	ABC transporter
MGAS23530_RS06295	COG1131	(ABC) transporter
MGAS23530_RS06300	COG0537	adenosine 5'-monophosphoramidase activity
MGAS23530_RS06310	COG1316	TRANSCRIPTIONal
MGAS23530_RS06320	COG0802	atpase or kinase
MGAS23530_RS06325	COG2252	PERMEase
MGAS23530_RS06330	COG0561	phosphatase activity
MGAS23530_RS06340	COG3715	PTS system
MGAS23530_RS06345	COG3716	PTS system mannose fructose sorbose family IID component
MGAS23530_RS06370	COG0439	Biotin carboxylase
MGAS23530_RS06385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS23530_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS23530_RS06395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS23530_RS06420	COG1024	Enoyl-CoA hydratase
MGAS23530_RS06455	COG0588	phosphoglycerate mutase activity
MGAS23530_RS06460	COG2261	transglycosylase associated protein
MGAS23530_RS06485	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS23530_RS06485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS23530_RS06490	COG1335	isochorismatase
MGAS23530_RS06500	COG0436	Aminotransferase
MGAS23530_RS06510	COG0561	phosphatase activity
MGAS23530_RS06515	COG0252	asparaginase activity
MGAS23530_RS06530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS23530_RS06535	COG1129	ABC transporter
MGAS23530_RS06550	COG1132	(ABC) transporter
MGAS23530_RS06555	COG4988	ABC transporter
MGAS23530_RS06585	COG3942	CHAP domain
MGAS23530_RS06585	COG1388	LysM domain
MGAS23530_RS06615	COG1482	cell wall glycoprotein biosynthetic process
MGAS23530_RS06620	COG1940	carbohydrate kinase activity
MGAS23530_RS06630	COG1263	PTS System
MGAS23530_RS06630	COG2190	(PTS) system
MGAS23530_RS06630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS23530_RS06635	COG1621	beta-fructofuranosidase activity
MGAS23530_RS06640	COG1609	Transcriptional regulator
MGAS23530_RS06660	COG2131	deaminase
MGAS23530_RS06665	COG0006	proline dipeptidase activity
MGAS23530_RS06705	COG1194	a g-specific adenine glycosylase
MGAS23530_RS06715	COG3118	belongs to the thioredoxin family
MGAS23530_RS06745	COG0681	Belongs to the peptidase S26 family
MGAS23530_RS06750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS23530_RS06765	COG1882	Formate acetyltransferase
MGAS23530_RS06770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS23530_RS06785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS23530_RS06790	COG2814	Major facilitator Superfamily
MGAS23530_RS06795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS23530_RS06820	COG0789	Transcriptional regulator
MGAS23530_RS06835	COG2081	HI0933 family
MGAS23530_RS06845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS23530_RS06850	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS23530_RS06870	COG0456	acetyltransferase
MGAS23530_RS06875	COG1214	PFAM Peptidase M22, glycoprotease
MGAS23530_RS06890	COG0174	glutamine synthetase
MGAS23530_RS06895	COG0789	Transcriptional regulator
MGAS23530_RS06910	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS23530_RS06965	COG0668	transmembrane transport
MGAS23530_RS06975	COG4720	Psort location CytoplasmicMembrane, score
MGAS23530_RS06980	COG0351	phosphomethylpyrimidine kinase
MGAS23530_RS07030	COG5433	transposase activity
MGAS23530_RS07035	COG1929	Belongs to the glycerate kinase type-1 family
MGAS23530_RS07040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS23530_RS07070	COG0577	efflux transmembrane transporter activity
MGAS23530_RS07075	COG1136	(ABC) transporter
MGAS23530_RS07100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS23530_RS07100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS23530_RS07105	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS23530_RS07155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS23530_RS07160	COG1476	TRANSCRIPTIONal
MGAS23530_RS07180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS23530_RS07190	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS23530_RS07210	COG1045	serine acetyltransferase
MGAS23530_RS07225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS23530_RS07270	COG1846	Transcriptional regulator
MGAS23530_RS07290	COG4589	Belongs to the CDS family
MGAS23530_RS07300	COG1862	Preprotein translocase
MGAS23530_RS07310	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS23530_RS07320	COG3842	ATPase activity
MGAS23530_RS07360	COG2190	(PTS) system
MGAS23530_RS07360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS23530_RS07360	COG1263	PTS System
MGAS23530_RS07365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS23530_RS07380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS23530_RS07385	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS23530_RS07390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS23530_RS07430	COG0601	transmembrane transport
MGAS23530_RS07440	COG1122	ATPase activity
MGAS23530_RS07460	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS23530_RS07490	COG3711	transcriptional antiterminator
MGAS23530_RS07500	COG3942	CHAP domain
MGAS23530_RS07500	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS23530_RS07505	COG2205	protein histidine kinase activity
MGAS23530_RS07510	COG0745	RESPONSE REGULATOR receiver
MGAS23530_RS07515	COG0577	efflux transmembrane transporter activity
MGAS23530_RS07520	COG1136	(ABC) transporter
MGAS23530_RS07580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS23530_RS07595	COG1882	Formate acetyltransferase
MGAS23530_RS07600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS23530_RS07605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS23530_RS07610	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS23530_RS07615	COG2390	Transcriptional regulator
MGAS23530_RS07620	COG1349	DNA-binding transcription factor activity
MGAS23530_RS07625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS23530_RS07635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS23530_RS07650	COG0564	pseudouridine synthase activity
MGAS23530_RS07680	COG0542	response to heat
MGAS23530_RS07685	COG4463	regulation of RNA biosynthetic process
MGAS23530_RS07700	COG0450	alkyl hydroperoxide reductase
MGAS23530_RS07715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS23530_RS07725	COG3404	Formiminotransferase-cyclodeaminase
MGAS23530_RS07740	COG0531	amino acid
MGAS23530_RS07770	COG3590	peptidase
MGAS23530_RS07775	COG0366	Alpha amylase catalytic
MGAS23530_RS07780	COG1263	PTS System
MGAS23530_RS07780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS23530_RS07785	COG2188	Transcriptional regulator
MGAS23530_RS07795	COG5433	transposase activity
MGAS23530_RS07800	COG2514	catechol 2,3-dioxygenase activity
MGAS23530_RS07810	COG0602	queuosine metabolic process
MGAS23530_RS07825	COG1328	CTP reductase activity
MGAS23530_RS07850	COG1393	Belongs to the ArsC family
MGAS23530_RS07865	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS23530_RS07910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS23530_RS07915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS23530_RS07920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS23530_RS08005	COG1511	domain protein
MGAS23530_RS08025	COG5433	transposase activity
MGAS23530_RS08035	COG0305	Participates in initiation and elongation during chromosome replication
MGAS23530_RS08065	COG1760	l-serine dehydratase
MGAS23530_RS08070	COG1760	l-serine dehydratase
MGAS23530_RS08075	COG0741	lytic transglycosylase activity
MGAS23530_RS08080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS23530_RS08095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS23530_RS08105	COG0612	Peptidase, M16
MGAS23530_RS08145	COG0517	IMP dehydrogenase activity
MGAS23530_RS08145	COG0516	GMP reductase activity
MGAS23530_RS08155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS23530_RS08160	COG0488	(ABC) transporter
MGAS23530_RS08195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS23530_RS08200	COG1475	DNA binding