locus-tag	class	description
JF649_RS00010	COG0592	DNA-directed DNA polymerase activity
JF649_RS00020	COG0012	GTP binding
JF649_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JF649_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JF649_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JF649_RS00065	COG0531	amino acid
JF649_RS00240	COG3942	CHAP domain
JF649_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JF649_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JF649_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JF649_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JF649_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JF649_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JF649_RS00355	COG1454	alcohol dehydrogenase
JF649_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
JF649_RS00360	COG1064	alcohol dehydrogenase
JF649_RS00365	COG0534	Mate efflux family protein
JF649_RS00475	COG0201	protein transport
JF649_RS00605	COG1121	(ABC) transporter
JF649_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JF649_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JF649_RS00650	COG1459	type II secretion system
JF649_RS00655	COG4537	Required for transformation and DNA binding
JF649_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JF649_RS00700	COG1363	Peptidase, m42
JF649_RS00710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JF649_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JF649_RS00725	COG1428	Deoxynucleoside kinase
JF649_RS00730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JF649_RS00785	COG2031	fatty acid transporter
JF649_RS00795	COG0183	Belongs to the thiolase family
JF649_RS00800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JF649_RS00815	COG0251	oxidation-reduction process
JF649_RS00830	COG1269	ATP hydrolysis coupled proton transport
JF649_RS00835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JF649_RS00845	COG1527	subunit (C
JF649_RS00850	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
JF649_RS00885	COG1744	ABC transporter substrate-binding protein PnrA-like
JF649_RS00930	COG0626	cystathionine gamma-synthase activity
JF649_RS00960	COG3623	hexulose-6-phosphate isomerase
JF649_RS00980	COG4175	Glycine betaine
JF649_RS00980	COG3448	diguanylate cyclase activity
JF649_RS00990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JF649_RS00990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JF649_RS01010	COG3969	phosphoadenosine phosphosulfate
JF649_RS01015	COG1475	DNA binding
JF649_RS01035	COG0157	Belongs to the NadC ModD family
JF649_RS01060	COG1268	BioY protein
JF649_RS01065	COG1234	tRNA 3'-trailer cleavage
JF649_RS01100	COG5433	transposase activity
JF649_RS01110	COG0705	Rhomboid family
JF649_RS01110	COG0457	Tetratricopeptide repeat
JF649_RS01130	COG1132	(ABC) transporter
JF649_RS01135	COG1132	(ABC) transporter
JF649_RS01145	COG0756	dUTP diphosphatase activity
JF649_RS01170	COG3290	protein histidine kinase activity
JF649_RS01195	COG1847	R3H domain protein
JF649_RS01215	COG1175	transmembrane transport
JF649_RS01220	COG0395	ABC-type sugar transport system, permease component
JF649_RS01230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JF649_RS01245	COG0084	hydrolase, TatD family'
JF649_RS01270	COG1564	THIamine pyrophosphokinase
JF649_RS01285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JF649_RS01325	COG0765	amino acid transport
JF649_RS01345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JF649_RS01355	COG0719	Fe-S assembly protein
JF649_RS01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JF649_RS01375	COG1686	Belongs to the peptidase S11 family
JF649_RS01380	COG1686	Belongs to the peptidase S11 family
JF649_RS01385	COG4166	transmembrane transport
JF649_RS01390	COG0601	transmembrane transport
JF649_RS01395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JF649_RS01400	COG0444	Belongs to the ABC transporter superfamily
JF649_RS01445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JF649_RS01450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JF649_RS01455	COG1534	Rna-binding protein
JF649_RS01465	COG1713	HD superfamily hydrolase involved in NAD metabolism
JF649_RS01470	COG0799	negative regulation of ribosome biogenesis
JF649_RS01475	COG2226	methyltransferase
JF649_RS01490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JF649_RS01495	COG1464	Belongs to the NlpA lipoprotein family
JF649_RS01510	COG1114	Component of the transport system for branched-chain amino acids
JF649_RS01520	COG0569	domain protein
JF649_RS01525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JF649_RS01535	COG1704	LemA family
JF649_RS01550	COG0745	RESPONSE REGULATOR receiver
JF649_RS01560	COG5433	transposase activity
JF649_RS01580	COG1484	DNA-dependent DNA replication
JF649_RS01590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JF649_RS01610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JF649_RS01625	COG1254	Belongs to the acylphosphatase family
JF649_RS01630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JF649_RS01685	COG1187	pseudouridine synthase activity
JF649_RS01700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JF649_RS01705	COG0671	phosphoesterase, PA-phosphatase related
JF649_RS01710	COG1242	4 iron, 4 sulfur cluster binding
JF649_RS01715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JF649_RS01720	COG1253	flavin adenine dinucleotide binding
JF649_RS01725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JF649_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JF649_RS01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JF649_RS01750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JF649_RS01755	COG1120	ATPase activity
JF649_RS01765	COG2244	polysaccharide biosynthetic process
JF649_RS01790	COG0470	DNA polymerase III
JF649_RS01820	COG1393	Belongs to the ArsC family
JF649_RS01825	COG0708	Exodeoxyribonuclease III
JF649_RS01830	COG1304	FMN binding
JF649_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
JF649_RS01940	COG0673	inositol 2-dehydrogenase activity
JF649_RS01955	COG0494	nUDIX hydrolase
JF649_RS01965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JF649_RS02055	COG1702	phosphate starvation-inducible protein PhoH
JF649_RS02060	COG1573	uracil-dna glycosylase
JF649_RS02070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JF649_RS02155	COG0433	COG0433 Predicted ATPase
JF649_RS02175	COG0557	exoribonuclease II activity
JF649_RS02205	COG0463	Glycosyl transferase, family 2
JF649_RS02215	COG0778	Nitroreductase
JF649_RS02220	COG0006	proline dipeptidase activity
JF649_RS02225	COG1609	Transcriptional regulator
JF649_RS02235	COG0438	transferase activity, transferring glycosyl groups
JF649_RS02245	COG4555	ABC transporter
JF649_RS02265	COG0183	Belongs to the thiolase family
JF649_RS02280	COG0745	RESPONSE REGULATOR receiver
JF649_RS02285	COG5002	protein histidine kinase activity
JF649_RS02290	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JF649_RS02300	COG1196	nuclear chromosome segregation
JF649_RS02315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JF649_RS02430	COG0124	histidyl-tRNA synthetase
JF649_RS02440	COG0561	phosphatase activity
JF649_RS02445	COG0561	phosphatase activity
JF649_RS02450	COG0552	protein localization to endoplasmic reticulum
JF649_RS02455	COG0477	Major facilitator Superfamily
JF649_RS02460	COG3711	transcriptional antiterminator
JF649_RS02465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JF649_RS02465	COG1263	PTS System
JF649_RS02465	COG2190	(PTS) system
JF649_RS02475	COG3689	TIGRFAM TIGR03943 family protein
JF649_RS02480	COG0701	Predicted permease
JF649_RS02490	COG2183	response to ionizing radiation
JF649_RS02535	COG0826	peptidase U32
JF649_RS02540	COG4443	Transcriptional Coactivator p15 (PC4)
JF649_RS02590	COG0386	Belongs to the glutathione peroxidase family
JF649_RS02595	COG1164	Oligoendopeptidase f
JF649_RS02605	COG0772	Belongs to the SEDS family
JF649_RS02635	COG1078	dGTPase activity
JF649_RS02650	COG1609	Transcriptional regulator
JF649_RS02660	COG3716	PTS system mannose fructose sorbose family IID component
JF649_RS02665	COG3715	PTS system
JF649_RS02670	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JF649_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
JF649_RS02700	COG0800	Aldolase
JF649_RS02705	COG0546	phosphoglycolate phosphatase activity
JF649_RS02710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JF649_RS02720	COG2884	Cell division ATP-binding protein ftsE
JF649_RS02725	COG2177	Part of the ABC transporter FtsEX involved in
JF649_RS02740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JF649_RS02740	COG1199	ATP-dependent helicase activity
JF649_RS02745	COG0436	Aminotransferase
JF649_RS02780	COG2188	Transcriptional regulator
JF649_RS02785	COG2222	sugar isomerase
JF649_RS02795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JF649_RS02800	COG0716	FMN binding
JF649_RS02810	COG0038	chloride channel
JF649_RS02920	COG1131	(ABC) transporter
JF649_RS02940	COG5433	transposase activity
JF649_RS02950	COG4708	membrane
JF649_RS02960	COG1597	lipid kinase activity
JF649_RS03045	COG0577	efflux transmembrane transporter activity
JF649_RS03055	COG2321	neutral zinc metallopeptidase
JF649_RS03080	COG1970	mechanosensitive ion channel activity
JF649_RS03085	COG0358	DNA primase activity
JF649_RS03090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JF649_RS03095	COG2151	metal-sulfur cluster biosynthetic enzyme
JF649_RS03140	COG1216	Glycosyl transferase, family 2
JF649_RS03200	COG1368	sulfuric ester hydrolase activity
JF649_RS03205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JF649_RS03225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JF649_RS03230	COG0285	dihydrofolate synthase activity
JF649_RS03240	COG1104	cysteine desulfurase activity
JF649_RS03265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JF649_RS03270	COG0583	DNA-binding transcription factor activity
JF649_RS03280	COG0564	pseudouridine synthase activity
JF649_RS03285	COG5433	transposase activity
JF649_RS03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JF649_RS03320	COG1136	(ABC) transporter
JF649_RS03325	COG0577	efflux transmembrane transporter activity
JF649_RS03330	COG0584	glycerophosphoryl diester phosphodiesterase
JF649_RS03340	COG1837	Belongs to the UPF0109 family
JF649_RS03390	COG1349	DNA-binding transcription factor activity
JF649_RS03395	COG1105	Belongs to the carbohydrate kinase PfkB family
JF649_RS03400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JF649_RS03400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JF649_RS03400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JF649_RS03405	COG1388	LysM domain
JF649_RS03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
JF649_RS03410	COG1388	LysM domain
JF649_RS03410	COG1705	Flagellar rod assembly protein muramidase FlgJ
JF649_RS03430	COG0105	UTP biosynthetic process
JF649_RS03450	COG0488	(ABC) transporter
JF649_RS03460	COG0242	peptide deformylase activity
JF649_RS03465	COG0737	Belongs to the 5'-nucleotidase family
JF649_RS03470	COG2357	RelA SpoT domain protein
JF649_RS03475	COG0745	RESPONSE REGULATOR receiver
JF649_RS03510	COG3425	synthase
JF649_RS03520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JF649_RS03565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JF649_RS03580	COG0583	DNA-binding transcription factor activity
JF649_RS03605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JF649_RS03610	COG0765	amino acid transport
JF649_RS03630	COG0187	DNA topoisomerase II activity
JF649_RS03640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JF649_RS03660	COG0539	negative regulation of cytoplasmic translation
JF649_RS03700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JF649_RS03705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JF649_RS03715	COG0300	oxidoreductase activity
JF649_RS03720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JF649_RS03720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JF649_RS03735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JF649_RS03740	COG2384	SAM-dependent methyltransferase
JF649_RS03750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JF649_RS03755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JF649_RS03765	COG1088	dTDP-glucose 4,6-dehydratase activity
JF649_RS03770	COG0582	viral genome integration into host DNA
JF649_RS03890	COG1783	phage Terminase large subunit
JF649_RS03995	COG4824	toxin secretion phage lysis holin
JF649_RS04015	COG1051	belongs to the nudix hydrolase family
JF649_RS04020	COG0628	permease
JF649_RS04025	COG0457	Tetratricopeptide repeat
JF649_RS04030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JF649_RS04045	COG1129	ABC transporter
JF649_RS04065	COG0488	(ABC) transporter
JF649_RS04070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JF649_RS04075	COG0508	dehydrogenase complex catalyzes the overall conversion of
JF649_RS04075	COG0022	dehydrogenase e1 component
JF649_RS04080	COG0508	dehydrogenase complex catalyzes the overall conversion of
JF649_RS04090	COG5492	domain, Protein
JF649_RS04095	COG0095	Lipoate-protein ligase
JF649_RS04100	COG3442	glutamine amidotransferase
JF649_RS04105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JF649_RS04110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JF649_RS04130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JF649_RS04140	COG0647	UMP catabolic process
JF649_RS04185	COG3715	PTS system
JF649_RS04190	COG3716	PTS system mannose fructose sorbose family IID component
JF649_RS04195	COG2972	Histidine kinase
JF649_RS04200	COG2207	Transcriptional regulator
JF649_RS04200	COG4753	response regulator
JF649_RS04210	COG1012	belongs to the aldehyde dehydrogenase family
JF649_RS04225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JF649_RS04280	COG1131	(ABC) transporter
JF649_RS04295	COG1396	sequence-specific DNA binding
JF649_RS04320	COG0285	dihydrofolate synthase activity
JF649_RS04340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JF649_RS04355	COG1176	ABC-type spermidine putrescine transport system, permease component I
JF649_RS04360	COG1177	transmembrane transport
JF649_RS04370	COG4565	transcriptional regulatory protein
JF649_RS04375	COG3290	protein histidine kinase activity
JF649_RS04380	COG3493	citrate carrier protein
JF649_RS04395	COG3700	Belongs to the class B bacterial acid phosphatase family
JF649_RS04400	COG0038	chloride channel
JF649_RS04410	COG0628	permease
JF649_RS04420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JF649_RS04435	COG1104	cysteine desulfurase activity
JF649_RS04450	COG2357	RelA SpoT domain protein
JF649_RS04460	COG0564	pseudouridine synthase activity
JF649_RS04465	COG0280	phosphate acetyltransferase
JF649_RS04470	COG4221	oxidoreductase activity
JF649_RS04485	COG1174	glycine betaine transport
JF649_RS04500	COG2233	PERMEase
JF649_RS04525	COG2890	protein-(glutamine-N5) methyltransferase activity
JF649_RS04555	COG1132	(ABC) transporter
JF649_RS04560	COG1132	(ABC) transporter
JF649_RS04580	COG3764	Sortase (surface protein transpeptidase)
JF649_RS04585	COG0346	lactoylglutathione lyase activity
JF649_RS04600	COG1272	protein, Hemolysin III
JF649_RS04620	COG0758	DNA mediated transformation
JF649_RS04625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JF649_RS04670	COG0511	ligase activity, forming carbon-carbon bonds
JF649_RS04675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JF649_RS04690	COG2851	Citrate transporter
JF649_RS04700	COG0511	ligase activity, forming carbon-carbon bonds
JF649_RS04705	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JF649_RS04735	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
JF649_RS04755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JF649_RS04765	COG2188	Transcriptional regulator
JF649_RS04785	COG0488	(ABC) transporter
JF649_RS04795	COG0351	phosphomethylpyrimidine kinase
JF649_RS04795	COG0352	thiamine-phosphate diphosphorylase activity
JF649_RS04800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JF649_RS04805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JF649_RS04805	COG1328	CTP reductase activity
JF649_RS04810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JF649_RS04840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JF649_RS04860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JF649_RS04865	COG4684	Psort location CytoplasmicMembrane, score
JF649_RS04870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JF649_RS04875	COG1079	Belongs to the binding-protein-dependent transport system permease family
JF649_RS04880	COG4603	Belongs to the binding-protein-dependent transport system permease family
JF649_RS04885	COG3845	ABC transporter
JF649_RS04890	COG1744	ABC transporter substrate-binding protein PnrA-like
JF649_RS04895	COG0295	cytidine deaminase activity
JF649_RS04900	COG2813	Specifically methylates the guanine in position
JF649_RS04915	COG5002	protein histidine kinase activity
JF649_RS04920	COG0745	RESPONSE REGULATOR receiver
JF649_RS04930	COG0704	Plays a role in the regulation of phosphate uptake
JF649_RS04945	COG0581	inorganic phosphate transmembrane transporter activity
JF649_RS04950	COG0573	inorganic phosphate transmembrane transporter activity
JF649_RS04960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JF649_RS04960	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JF649_RS04965	COG0483	inositol monophosphate 1-phosphatase activity
JF649_RS04980	COG0196	riboflavin kinase activity
JF649_RS05010	COG1136	(ABC) transporter
JF649_RS05010	COG4591	ABC-type transport system involved in lipoprotein release permease component
JF649_RS05060	COG1115	amino acid carrier protein
JF649_RS05065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JF649_RS05075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JF649_RS05080	COG1126	abc transporter atp-binding protein
JF649_RS05085	COG0765	amino acid transport
JF649_RS05090	COG2824	Alkylphosphonate utilization operon protein PhnA
JF649_RS05105	COG0469	pyruvate kinase activity
JF649_RS05120	COG1725	Transcriptional regulator
JF649_RS05125	COG1131	(ABC) transporter
JF649_RS05150	COG0058	SHG alpha-glucan phosphorylase activity
JF649_RS05155	COG1640	4-alpha-glucanotransferase
JF649_RS05160	COG1609	Transcriptional regulator
JF649_RS05165	COG2182	Extracellular solute-binding protein
JF649_RS05170	COG1175	transmembrane transport
JF649_RS05175	COG3833	ABC-type maltose transport systems, permease component
JF649_RS05190	COG0657	acetylesterase activity
JF649_RS05195	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JF649_RS05205	COG1696	Membrane protein involved in D-alanine export
JF649_RS05225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JF649_RS05230	COG1126	abc transporter atp-binding protein
JF649_RS05235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JF649_RS05245	COG1447	Phosphotransferase system cellobiose-specific component IIA
JF649_RS05255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JF649_RS05255	COG3711	transcriptional antiterminator
JF649_RS05265	COG2723	6-phospho-beta-galactosidase activity
JF649_RS05295	COG1187	pseudouridine synthase activity
JF649_RS05305	COG2814	Major facilitator Superfamily
JF649_RS05355	COG4109	DRTGG domain
JF649_RS05360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JF649_RS05385	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JF649_RS05385	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JF649_RS05395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JF649_RS05400	COG1956	GAF domain-containing protein
JF649_RS05420	COG0513	Belongs to the DEAD box helicase family
JF649_RS05425	COG0726	polysaccharide deacetylase
JF649_RS05445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JF649_RS05450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JF649_RS05455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JF649_RS05480	COG1476	TRANSCRIPTIONal
JF649_RS05495	COG5433	transposase activity
JF649_RS05505	COG4122	O-methyltransferase activity
JF649_RS05510	COG2223	nitrite transmembrane transporter activity
JF649_RS05525	COG1187	pseudouridine synthase activity
JF649_RS05570	COG0658	competence protein
JF649_RS05570	COG2333	competence protein COMEC
JF649_RS05575	COG1555	photosystem II stabilization
JF649_RS05575	COG1596	polysaccharide export
JF649_RS05580	COG0204	Acyl-transferase
JF649_RS05585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JF649_RS05600	COG0513	Belongs to the DEAD box helicase family
JF649_RS05615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JF649_RS05630	COG2116	formate transmembrane transporter activity
JF649_RS05640	COG1827	regulation of RNA biosynthetic process
JF649_RS05655	COG2217	Heavy metal translocating P-type atpase
JF649_RS05680	COG4824	toxin secretion phage lysis holin
JF649_RS05865	COG3723	Recombinational DNA repair protein, rece pathway
JF649_RS05915	COG1396	sequence-specific DNA binding
JF649_RS05925	COG0582	viral genome integration into host DNA
JF649_RS05940	COG2755	lipolytic protein G-D-S-L family
JF649_RS05955	COG0497	DNA recombination
JF649_RS05960	COG1438	arginine binding
JF649_RS05965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JF649_RS05990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JF649_RS05995	COG0415	Belongs to the DNA photolyase family
JF649_RS06005	COG0765	amino acid transport
JF649_RS06010	COG4703	Protein of unknown function (DUF1797)
JF649_RS06015	COG0542	response to heat
JF649_RS06020	COG0494	nUDIX hydrolase
JF649_RS06035	COG3599	regulation of cell shape
JF649_RS06040	COG2302	S4 RNA-binding domain
JF649_RS06055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JF649_RS06090	COG1217	gtp-binding protein TYPA
JF649_RS06095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JF649_RS06100	COG1940	carbohydrate kinase activity
JF649_RS06110	COG0783	Belongs to the Dps family
JF649_RS06125	COG4470	Protein conserved in bacteria
JF649_RS06130	COG1609	Transcriptional regulator
JF649_RS06135	COG3480	Lon protease (S16) C-terminal proteolytic domain
JF649_RS06145	COG0742	ribosomal rna small subunit methyltransferase
JF649_RS06155	COG0549	Belongs to the carbamate kinase family
JF649_RS06160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JF649_RS06165	COG1288	antiporter activity
JF649_RS06180	COG2235	arginine
JF649_RS06205	COG2972	Histidine kinase
JF649_RS06220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JF649_RS06225	COG0785	Cytochrome C biogenesis protein
JF649_RS06230	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JF649_RS06235	COG1518	maintenance of DNA repeat elements
JF649_RS06295	COG1605	Chorismate mutase
JF649_RS06295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JF649_RS06315	COG2226	methyltransferase
JF649_RS06325	COG3250	beta-galactosidase activity
JF649_RS06330	COG4753	response regulator
JF649_RS06330	COG2207	Transcriptional regulator
JF649_RS06335	COG2972	Histidine kinase
JF649_RS06345	COG1653	transport
JF649_RS06350	COG0395	ABC-type sugar transport system, permease component
JF649_RS06355	COG1175	transmembrane transport
JF649_RS06360	COG1940	carbohydrate kinase activity
JF649_RS06365	COG2723	6-phospho-beta-galactosidase activity
JF649_RS06370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JF649_RS06385	COG0383	alpha-mannosidase activity
JF649_RS06480	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JF649_RS06485	COG1739	Uncharacterized protein family UPF0029
JF649_RS06495	COG1098	S1 RNA binding domain
JF649_RS06505	COG2197	response regulator
JF649_RS06510	COG4585	Histidine kinase
JF649_RS06520	COG0515	serine threonine protein kinase
JF649_RS06520	COG2815	serine threonine protein kinase
JF649_RS06530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JF649_RS06530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JF649_RS06540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JF649_RS06560	COG0583	DNA-binding transcription factor activity
JF649_RS06565	COG0183	Belongs to the thiolase family
JF649_RS06570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JF649_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
JF649_RS06600	COG0116	Belongs to the methyltransferase superfamily
JF649_RS06625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JF649_RS06630	COG3579	cysteine-type endopeptidase activity
JF649_RS06640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JF649_RS06645	COG1113	amino acid transport
JF649_RS06650	COG0492	ferredoxin-NADP+ reductase activity
JF649_RS06660	COG1126	abc transporter atp-binding protein
JF649_RS06670	COG0513	Belongs to the DEAD box helicase family
JF649_RS06680	COG0768	penicillin binding
JF649_RS06715	COG1131	(ABC) transporter
JF649_RS06740	COG0446	pyridine nucleotide-disulphide oxidoreductase
JF649_RS06745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JF649_RS06780	COG1755	Isoprenylcysteine carboxyl methyltransferase
JF649_RS06785	COG0656	L-ascorbic acid biosynthetic process
JF649_RS06795	COG1283	sodium-dependent phosphate transmembrane transporter activity
JF649_RS06815	COG0561	phosphatase activity
JF649_RS06820	COG2860	membrane
JF649_RS06865	COG2217	Heavy metal translocating P-type atpase
JF649_RS06895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JF649_RS06900	COG0195	Participates in both transcription termination and antitermination
JF649_RS06925	COG4473	ABC transporter
JF649_RS06930	COG1131	(ABC) transporter
JF649_RS06935	COG0537	adenosine 5'-monophosphoramidase activity
JF649_RS06945	COG1316	TRANSCRIPTIONal
JF649_RS06955	COG0802	atpase or kinase
JF649_RS06960	COG2252	PERMEase
JF649_RS06965	COG0561	phosphatase activity
JF649_RS06975	COG3715	PTS system
JF649_RS06980	COG3716	PTS system mannose fructose sorbose family IID component
JF649_RS07005	COG0439	Biotin carboxylase
JF649_RS07020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JF649_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
JF649_RS07030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JF649_RS07055	COG1024	Enoyl-CoA hydratase
JF649_RS07060	COG0484	heat shock protein binding
JF649_RS07090	COG0588	phosphoglycerate mutase activity
JF649_RS07095	COG2261	transglycosylase associated protein
JF649_RS07120	COG0574	Belongs to the PEP-utilizing enzyme family
JF649_RS07120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JF649_RS07125	COG1335	isochorismatase
JF649_RS07135	COG0436	Aminotransferase
JF649_RS07145	COG0561	phosphatase activity
JF649_RS07150	COG0252	asparaginase activity
JF649_RS07165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JF649_RS07170	COG1129	ABC transporter
JF649_RS07185	COG1132	(ABC) transporter
JF649_RS07190	COG4988	ABC transporter
JF649_RS07195	COG1120	ATPase activity
JF649_RS07220	COG1388	LysM domain
JF649_RS07220	COG3942	CHAP domain
JF649_RS07240	COG1482	cell wall glycoprotein biosynthetic process
JF649_RS07245	COG1940	carbohydrate kinase activity
JF649_RS07255	COG1263	PTS System
JF649_RS07255	COG2190	(PTS) system
JF649_RS07255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JF649_RS07260	COG1621	beta-fructofuranosidase activity
JF649_RS07265	COG1609	Transcriptional regulator
JF649_RS07285	COG2131	deaminase
JF649_RS07290	COG0006	proline dipeptidase activity
JF649_RS07330	COG1194	a g-specific adenine glycosylase
JF649_RS07340	COG3118	belongs to the thioredoxin family
JF649_RS07370	COG0681	Belongs to the peptidase S26 family
JF649_RS07375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JF649_RS07390	COG1882	Formate acetyltransferase
JF649_RS07395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JF649_RS07410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JF649_RS07415	COG2814	Major facilitator Superfamily
JF649_RS07420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JF649_RS07445	COG0789	Transcriptional regulator
JF649_RS07475	COG2081	HI0933 family
JF649_RS07485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JF649_RS07490	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JF649_RS07510	COG0456	acetyltransferase
JF649_RS07515	COG1214	PFAM Peptidase M22, glycoprotease
JF649_RS07530	COG0174	glutamine synthetase
JF649_RS07535	COG0789	Transcriptional regulator
JF649_RS07550	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JF649_RS07605	COG0668	transmembrane transport
JF649_RS07615	COG4720	Psort location CytoplasmicMembrane, score
JF649_RS07620	COG0351	phosphomethylpyrimidine kinase
JF649_RS07665	COG1929	Belongs to the glycerate kinase type-1 family
JF649_RS07670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JF649_RS07695	COG0577	efflux transmembrane transporter activity
JF649_RS07700	COG1136	(ABC) transporter
JF649_RS07725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JF649_RS07725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JF649_RS07730	COG1447	Phosphotransferase system cellobiose-specific component IIA
JF649_RS07780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JF649_RS07785	COG1476	TRANSCRIPTIONal
JF649_RS07805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JF649_RS07815	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JF649_RS07830	COG1045	serine acetyltransferase
JF649_RS07845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JF649_RS07850	COG3037	sugar-specific permease SgaT UlaA
JF649_RS07860	COG3711	transcriptional antiterminator
JF649_RS07890	COG1846	Transcriptional regulator
JF649_RS07910	COG4589	Belongs to the CDS family
JF649_RS07920	COG1862	Preprotein translocase
JF649_RS07930	COG1523	belongs to the glycosyl hydrolase 13 family
JF649_RS07940	COG3842	ATPase activity
JF649_RS07980	COG1263	PTS System
JF649_RS07980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JF649_RS07980	COG2190	(PTS) system
JF649_RS07985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JF649_RS08000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JF649_RS08005	COG0512	Glutamine amidotransferase of anthranilate synthase
JF649_RS08010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JF649_RS08045	COG0601	transmembrane transport
JF649_RS08075	COG0803	Belongs to the bacterial solute-binding protein 9 family
JF649_RS08105	COG3711	transcriptional antiterminator
JF649_RS08115	COG3942	CHAP domain
JF649_RS08115	COG1705	Flagellar rod assembly protein muramidase FlgJ
JF649_RS08120	COG2205	protein histidine kinase activity
JF649_RS08125	COG0745	RESPONSE REGULATOR receiver
JF649_RS08130	COG0577	efflux transmembrane transporter activity
JF649_RS08135	COG1136	(ABC) transporter
JF649_RS08200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JF649_RS08215	COG1882	Formate acetyltransferase
JF649_RS08220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JF649_RS08225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JF649_RS08230	COG1447	Phosphotransferase system cellobiose-specific component IIA
JF649_RS08235	COG2390	Transcriptional regulator
JF649_RS08240	COG1349	DNA-binding transcription factor activity
JF649_RS08245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JF649_RS08260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JF649_RS08275	COG0564	pseudouridine synthase activity
JF649_RS08310	COG0542	response to heat
JF649_RS08315	COG4463	regulation of RNA biosynthetic process
JF649_RS08330	COG0450	alkyl hydroperoxide reductase
JF649_RS08345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JF649_RS08355	COG3404	Formiminotransferase-cyclodeaminase
JF649_RS08370	COG0531	amino acid
JF649_RS08400	COG3590	peptidase
JF649_RS08405	COG0366	Alpha amylase catalytic
JF649_RS08410	COG1263	PTS System
JF649_RS08410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JF649_RS08415	COG2188	Transcriptional regulator
JF649_RS08420	COG1733	regulation of RNA biosynthetic process
JF649_RS08435	COG0602	queuosine metabolic process
JF649_RS08455	COG1328	CTP reductase activity
JF649_RS08480	COG1393	Belongs to the ArsC family
JF649_RS08495	COG0519	Catalyzes the synthesis of GMP from XMP
JF649_RS08505	COG2814	Major facilitator Superfamily
JF649_RS08540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JF649_RS08545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JF649_RS08550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JF649_RS08625	COG4974	Belongs to the 'phage' integrase family
JF649_RS08655	COG1511	domain protein
JF649_RS08675	COG0305	Participates in initiation and elongation during chromosome replication
JF649_RS08705	COG1760	l-serine dehydratase
JF649_RS08710	COG1760	l-serine dehydratase
JF649_RS08715	COG0741	lytic transglycosylase activity
JF649_RS08720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JF649_RS08735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JF649_RS08745	COG0612	Peptidase, M16
JF649_RS08755	COG1215	transferase activity, transferring glycosyl groups
JF649_RS08765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JF649_RS08785	COG0516	GMP reductase activity
JF649_RS08785	COG0517	IMP dehydrogenase activity
JF649_RS08795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JF649_RS08800	COG0488	(ABC) transporter
JF649_RS08835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JF649_RS08840	COG1475	DNA binding