locus-tag	class	description
MGAS27061_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS27061_RS00020	COG0012	GTP binding
MGAS27061_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS27061_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS27061_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS27061_RS00065	COG0531	amino acid
MGAS27061_RS00175	COG3942	CHAP domain
MGAS27061_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS27061_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS27061_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS27061_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS27061_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS27061_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS27061_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
MGAS27061_RS00285	COG1454	alcohol dehydrogenase
MGAS27061_RS00290	COG1064	alcohol dehydrogenase
MGAS27061_RS00295	COG0534	Mate efflux family protein
MGAS27061_RS00405	COG0201	protein transport
MGAS27061_RS00540	COG1121	(ABC) transporter
MGAS27061_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS27061_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS27061_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS27061_RS00585	COG1459	type II secretion system
MGAS27061_RS00590	COG4537	Required for transformation and DNA binding
MGAS27061_RS00625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS27061_RS00630	COG1363	Peptidase, m42
MGAS27061_RS00640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS27061_RS00645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS27061_RS00655	COG1428	Deoxynucleoside kinase
MGAS27061_RS00660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS27061_RS00700	COG4509	Sortase family
MGAS27061_RS00725	COG2031	fatty acid transporter
MGAS27061_RS00740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS27061_RS00755	COG0251	oxidation-reduction process
MGAS27061_RS00770	COG1269	ATP hydrolysis coupled proton transport
MGAS27061_RS00775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS27061_RS00785	COG1527	subunit (C
MGAS27061_RS00790	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS27061_RS00825	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS27061_RS00860	COG0626	cystathionine gamma-synthase activity
MGAS27061_RS00890	COG3623	hexulose-6-phosphate isomerase
MGAS27061_RS00910	COG4175	Glycine betaine
MGAS27061_RS00910	COG3448	diguanylate cyclase activity
MGAS27061_RS00920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS27061_RS00920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS27061_RS00940	COG3969	phosphoadenosine phosphosulfate
MGAS27061_RS00945	COG1475	DNA binding
MGAS27061_RS00955	COG2801	Transposase and inactivated derivatives
MGAS27061_RS00960	COG2801	Transposase and inactivated derivatives
MGAS27061_RS00975	COG0157	Belongs to the NadC ModD family
MGAS27061_RS00980	COG2801	Transposase and inactivated derivatives
MGAS27061_RS01000	COG1268	BioY protein
MGAS27061_RS01005	COG1234	tRNA 3'-trailer cleavage
MGAS27061_RS01040	COG0705	Rhomboid family
MGAS27061_RS01040	COG0457	Tetratricopeptide repeat
MGAS27061_RS01060	COG1132	(ABC) transporter
MGAS27061_RS01065	COG1132	(ABC) transporter
MGAS27061_RS01075	COG0756	dUTP diphosphatase activity
MGAS27061_RS01105	COG3290	protein histidine kinase activity
MGAS27061_RS01130	COG1847	R3H domain protein
MGAS27061_RS01150	COG1175	transmembrane transport
MGAS27061_RS01155	COG0395	ABC-type sugar transport system, permease component
MGAS27061_RS01170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS27061_RS01185	COG0084	hydrolase, TatD family'
MGAS27061_RS01210	COG1564	THIamine pyrophosphokinase
MGAS27061_RS01225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS27061_RS01250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MGAS27061_RS01260	COG0765	amino acid transport
MGAS27061_RS01280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS27061_RS01290	COG0719	Fe-S assembly protein
MGAS27061_RS01295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS27061_RS01310	COG1686	Belongs to the peptidase S11 family
MGAS27061_RS01315	COG1686	Belongs to the peptidase S11 family
MGAS27061_RS01320	COG4166	transmembrane transport
MGAS27061_RS01325	COG0601	transmembrane transport
MGAS27061_RS01330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS27061_RS01335	COG0444	Belongs to the ABC transporter superfamily
MGAS27061_RS01385	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS27061_RS01390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS27061_RS01395	COG1534	Rna-binding protein
MGAS27061_RS01405	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS27061_RS01410	COG0799	negative regulation of ribosome biogenesis
MGAS27061_RS01415	COG2226	methyltransferase
MGAS27061_RS01430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27061_RS01435	COG1464	Belongs to the NlpA lipoprotein family
MGAS27061_RS01450	COG1114	Component of the transport system for branched-chain amino acids
MGAS27061_RS01460	COG0569	domain protein
MGAS27061_RS01465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS27061_RS01475	COG1704	LemA family
MGAS27061_RS01490	COG0745	RESPONSE REGULATOR receiver
MGAS27061_RS01510	COG1484	DNA-dependent DNA replication
MGAS27061_RS01520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS27061_RS01540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS27061_RS01555	COG1254	Belongs to the acylphosphatase family
MGAS27061_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS27061_RS01615	COG1187	pseudouridine synthase activity
MGAS27061_RS01630	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS27061_RS01635	COG0671	phosphoesterase, PA-phosphatase related
MGAS27061_RS01640	COG1242	4 iron, 4 sulfur cluster binding
MGAS27061_RS01645	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS27061_RS01650	COG1253	flavin adenine dinucleotide binding
MGAS27061_RS01655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS27061_RS01670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS27061_RS01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS27061_RS01680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS27061_RS01685	COG1120	ATPase activity
MGAS27061_RS01695	COG2244	polysaccharide biosynthetic process
MGAS27061_RS01720	COG0470	DNA polymerase III
MGAS27061_RS01745	COG1393	Belongs to the ArsC family
MGAS27061_RS01750	COG0708	Exodeoxyribonuclease III
MGAS27061_RS01760	COG1304	FMN binding
MGAS27061_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27061_RS01860	COG0673	inositol 2-dehydrogenase activity
MGAS27061_RS01875	COG0494	nUDIX hydrolase
MGAS27061_RS01885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS27061_RS01930	COG5433	transposase activity
MGAS27061_RS01985	COG1702	phosphate starvation-inducible protein PhoH
MGAS27061_RS01990	COG1573	uracil-dna glycosylase
MGAS27061_RS02000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS27061_RS02085	COG0433	COG0433 Predicted ATPase
MGAS27061_RS02090	COG2814	Major facilitator Superfamily
MGAS27061_RS02100	COG0557	exoribonuclease II activity
MGAS27061_RS02130	COG0463	Glycosyl transferase, family 2
MGAS27061_RS02140	COG0778	Nitroreductase
MGAS27061_RS02145	COG0006	proline dipeptidase activity
MGAS27061_RS02150	COG1609	Transcriptional regulator
MGAS27061_RS02160	COG0438	transferase activity, transferring glycosyl groups
MGAS27061_RS02170	COG4555	ABC transporter
MGAS27061_RS02190	COG0183	Belongs to the thiolase family
MGAS27061_RS02205	COG0745	RESPONSE REGULATOR receiver
MGAS27061_RS02210	COG5002	protein histidine kinase activity
MGAS27061_RS02215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS27061_RS02225	COG1196	nuclear chromosome segregation
MGAS27061_RS02235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS27061_RS02320	COG4695	Portal protein
MGAS27061_RS02330	COG0561	phosphatase activity
MGAS27061_RS02335	COG0561	phosphatase activity
MGAS27061_RS02340	COG0552	protein localization to endoplasmic reticulum
MGAS27061_RS02345	COG0477	Major facilitator Superfamily
MGAS27061_RS02350	COG3711	transcriptional antiterminator
MGAS27061_RS02355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27061_RS02355	COG1263	PTS System
MGAS27061_RS02355	COG2190	(PTS) system
MGAS27061_RS02365	COG3689	TIGRFAM TIGR03943 family protein
MGAS27061_RS02370	COG0701	Predicted permease
MGAS27061_RS02375	COG2183	response to ionizing radiation
MGAS27061_RS02420	COG0826	peptidase U32
MGAS27061_RS02425	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS27061_RS02470	COG0386	Belongs to the glutathione peroxidase family
MGAS27061_RS02475	COG1164	Oligoendopeptidase f
MGAS27061_RS02485	COG0772	Belongs to the SEDS family
MGAS27061_RS02520	COG1078	dGTPase activity
MGAS27061_RS02535	COG1609	Transcriptional regulator
MGAS27061_RS02545	COG3716	PTS system mannose fructose sorbose family IID component
MGAS27061_RS02550	COG3715	PTS system
MGAS27061_RS02555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27061_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27061_RS02595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS27061_RS02605	COG2884	Cell division ATP-binding protein ftsE
MGAS27061_RS02610	COG2177	Part of the ABC transporter FtsEX involved in
MGAS27061_RS02625	COG1199	ATP-dependent helicase activity
MGAS27061_RS02625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS27061_RS02630	COG0436	Aminotransferase
MGAS27061_RS02795	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27061_RS02820	COG2188	Transcriptional regulator
MGAS27061_RS02825	COG2222	sugar isomerase
MGAS27061_RS02835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS27061_RS02840	COG0716	FMN binding
MGAS27061_RS02850	COG0038	chloride channel
MGAS27061_RS02920	COG1131	(ABC) transporter
MGAS27061_RS02940	COG4708	membrane
MGAS27061_RS02950	COG1597	lipid kinase activity
MGAS27061_RS03035	COG0577	efflux transmembrane transporter activity
MGAS27061_RS03040	COG1136	(ABC) transporter
MGAS27061_RS03045	COG2321	neutral zinc metallopeptidase
MGAS27061_RS03060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27061_RS03070	COG1970	mechanosensitive ion channel activity
MGAS27061_RS03075	COG0358	DNA primase activity
MGAS27061_RS03080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS27061_RS03085	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS27061_RS03130	COG1216	Glycosyl transferase, family 2
MGAS27061_RS03185	COG1368	sulfuric ester hydrolase activity
MGAS27061_RS03190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS27061_RS03210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS27061_RS03215	COG0285	dihydrofolate synthase activity
MGAS27061_RS03225	COG1104	cysteine desulfurase activity
MGAS27061_RS03250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS27061_RS03255	COG0583	DNA-binding transcription factor activity
MGAS27061_RS03265	COG0564	pseudouridine synthase activity
MGAS27061_RS03295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS27061_RS03300	COG1136	(ABC) transporter
MGAS27061_RS03305	COG0577	efflux transmembrane transporter activity
MGAS27061_RS03310	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS27061_RS03320	COG1837	Belongs to the UPF0109 family
MGAS27061_RS03370	COG1349	DNA-binding transcription factor activity
MGAS27061_RS03375	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS27061_RS03380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS27061_RS03380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS27061_RS03380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS27061_RS03385	COG1388	LysM domain
MGAS27061_RS03385	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27061_RS03390	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27061_RS03390	COG1388	LysM domain
MGAS27061_RS03410	COG0105	UTP biosynthetic process
MGAS27061_RS03430	COG0488	(ABC) transporter
MGAS27061_RS03440	COG0242	peptide deformylase activity
MGAS27061_RS03450	COG2357	RelA SpoT domain protein
MGAS27061_RS03455	COG0745	RESPONSE REGULATOR receiver
MGAS27061_RS03490	COG3425	synthase
MGAS27061_RS03500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS27061_RS03555	COG0583	DNA-binding transcription factor activity
MGAS27061_RS03580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27061_RS03585	COG0765	amino acid transport
MGAS27061_RS03605	COG0187	DNA topoisomerase II activity
MGAS27061_RS03615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS27061_RS03635	COG0539	negative regulation of cytoplasmic translation
MGAS27061_RS03670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS27061_RS03675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS27061_RS03685	COG0300	oxidoreductase activity
MGAS27061_RS03690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS27061_RS03690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS27061_RS03705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS27061_RS03710	COG2384	SAM-dependent methyltransferase
MGAS27061_RS03720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS27061_RS03725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS27061_RS03735	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS27061_RS03740	COG1051	belongs to the nudix hydrolase family
MGAS27061_RS03745	COG0628	permease
MGAS27061_RS03750	COG0457	Tetratricopeptide repeat
MGAS27061_RS03755	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS27061_RS03770	COG1129	ABC transporter
MGAS27061_RS03790	COG0488	(ABC) transporter
MGAS27061_RS03795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS27061_RS03800	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS27061_RS03800	COG0022	dehydrogenase e1 component
MGAS27061_RS03805	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS27061_RS03820	COG5492	domain, Protein
MGAS27061_RS03825	COG0095	Lipoate-protein ligase
MGAS27061_RS03830	COG3442	glutamine amidotransferase
MGAS27061_RS03835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS27061_RS03840	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS27061_RS03860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS27061_RS03870	COG0647	UMP catabolic process
MGAS27061_RS03885	COG1518	maintenance of DNA repeat elements
MGAS27061_RS03890	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS27061_RS03905	COG0105	UTP biosynthetic process
MGAS27061_RS03940	COG3715	PTS system
MGAS27061_RS03945	COG3716	PTS system mannose fructose sorbose family IID component
MGAS27061_RS03950	COG2972	Histidine kinase
MGAS27061_RS03955	COG2207	Transcriptional regulator
MGAS27061_RS03955	COG4753	response regulator
MGAS27061_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
MGAS27061_RS03980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS27061_RS04060	COG1131	(ABC) transporter
MGAS27061_RS04115	COG0285	dihydrofolate synthase activity
MGAS27061_RS04135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS27061_RS04150	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS27061_RS04155	COG1177	transmembrane transport
MGAS27061_RS04165	COG4565	transcriptional regulatory protein
MGAS27061_RS04170	COG3290	protein histidine kinase activity
MGAS27061_RS04175	COG0281	malic enzyme
MGAS27061_RS04185	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS27061_RS04190	COG0038	chloride channel
MGAS27061_RS04200	COG0628	permease
MGAS27061_RS04210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS27061_RS04225	COG1104	cysteine desulfurase activity
MGAS27061_RS04240	COG2357	RelA SpoT domain protein
MGAS27061_RS04250	COG0564	pseudouridine synthase activity
MGAS27061_RS04255	COG0280	phosphate acetyltransferase
MGAS27061_RS04260	COG4221	oxidoreductase activity
MGAS27061_RS04275	COG1174	glycine betaine transport
MGAS27061_RS04290	COG2233	PERMEase
MGAS27061_RS04315	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS27061_RS04345	COG1132	(ABC) transporter
MGAS27061_RS04350	COG1132	(ABC) transporter
MGAS27061_RS04370	COG3764	Sortase (surface protein transpeptidase)
MGAS27061_RS04375	COG0346	lactoylglutathione lyase activity
MGAS27061_RS04390	COG1272	protein, Hemolysin III
MGAS27061_RS04410	COG0758	DNA mediated transformation
MGAS27061_RS04415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS27061_RS04460	COG0511	ligase activity, forming carbon-carbon bonds
MGAS27061_RS04465	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS27061_RS04480	COG2851	Citrate transporter
MGAS27061_RS04490	COG0511	ligase activity, forming carbon-carbon bonds
MGAS27061_RS04495	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS27061_RS04525	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS27061_RS04545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS27061_RS04555	COG2188	Transcriptional regulator
MGAS27061_RS04575	COG0488	(ABC) transporter
MGAS27061_RS04585	COG0352	thiamine-phosphate diphosphorylase activity
MGAS27061_RS04585	COG0351	phosphomethylpyrimidine kinase
MGAS27061_RS04590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS27061_RS04595	COG1328	CTP reductase activity
MGAS27061_RS04595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS27061_RS04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS27061_RS04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS27061_RS04650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS27061_RS04655	COG4684	Psort location CytoplasmicMembrane, score
MGAS27061_RS04660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS27061_RS04665	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS27061_RS04670	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS27061_RS04675	COG3845	ABC transporter
MGAS27061_RS04680	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS27061_RS04685	COG0295	cytidine deaminase activity
MGAS27061_RS04690	COG2813	Specifically methylates the guanine in position
MGAS27061_RS04705	COG5002	protein histidine kinase activity
MGAS27061_RS04710	COG0745	RESPONSE REGULATOR receiver
MGAS27061_RS04720	COG0704	Plays a role in the regulation of phosphate uptake
MGAS27061_RS04735	COG0581	inorganic phosphate transmembrane transporter activity
MGAS27061_RS04740	COG0573	inorganic phosphate transmembrane transporter activity
MGAS27061_RS04750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS27061_RS04750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS27061_RS04755	COG0483	inositol monophosphate 1-phosphatase activity
MGAS27061_RS04770	COG0196	riboflavin kinase activity
MGAS27061_RS04800	COG1136	(ABC) transporter
MGAS27061_RS04800	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS27061_RS04850	COG1115	amino acid carrier protein
MGAS27061_RS04855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS27061_RS04865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27061_RS04870	COG1126	abc transporter atp-binding protein
MGAS27061_RS04875	COG0765	amino acid transport
MGAS27061_RS04880	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS27061_RS04895	COG0469	pyruvate kinase activity
MGAS27061_RS04910	COG1725	Transcriptional regulator
MGAS27061_RS04915	COG1131	(ABC) transporter
MGAS27061_RS04940	COG0058	SHG alpha-glucan phosphorylase activity
MGAS27061_RS04945	COG1640	4-alpha-glucanotransferase
MGAS27061_RS04950	COG1609	Transcriptional regulator
MGAS27061_RS04955	COG2182	Extracellular solute-binding protein
MGAS27061_RS04960	COG1175	transmembrane transport
MGAS27061_RS04965	COG3833	ABC-type maltose transport systems, permease component
MGAS27061_RS04980	COG3833	ABC-type maltose transport systems, permease component
MGAS27061_RS04985	COG1175	transmembrane transport
MGAS27061_RS04995	COG0366	Alpha amylase catalytic
MGAS27061_RS05000	COG2182	Extracellular solute-binding protein
MGAS27061_RS05010	COG0657	acetylesterase activity
MGAS27061_RS05015	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS27061_RS05025	COG1696	Membrane protein involved in D-alanine export
MGAS27061_RS05045	COG0765	amino acid transport
MGAS27061_RS05050	COG1126	abc transporter atp-binding protein
MGAS27061_RS05055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27061_RS05065	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS27061_RS05075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS27061_RS05075	COG3711	transcriptional antiterminator
MGAS27061_RS05085	COG2723	6-phospho-beta-galactosidase activity
MGAS27061_RS05105	COG2801	Transposase and inactivated derivatives
MGAS27061_RS05110	COG1187	pseudouridine synthase activity
MGAS27061_RS05120	COG2814	Major facilitator Superfamily
MGAS27061_RS05170	COG4109	DRTGG domain
MGAS27061_RS05200	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS27061_RS05200	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS27061_RS05205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS27061_RS05210	COG1956	GAF domain-containing protein
MGAS27061_RS05230	COG0513	Belongs to the DEAD box helicase family
MGAS27061_RS05235	COG0726	polysaccharide deacetylase
MGAS27061_RS05255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS27061_RS05260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS27061_RS05265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS27061_RS05280	COG2801	Transposase and inactivated derivatives
MGAS27061_RS05285	COG2801	Transposase and inactivated derivatives
MGAS27061_RS05300	COG1476	TRANSCRIPTIONal
MGAS27061_RS05315	COG4122	O-methyltransferase activity
MGAS27061_RS05320	COG2223	nitrite transmembrane transporter activity
MGAS27061_RS05335	COG1187	pseudouridine synthase activity
MGAS27061_RS05380	COG2333	competence protein COMEC
MGAS27061_RS05380	COG0658	competence protein
MGAS27061_RS05385	COG1596	polysaccharide export
MGAS27061_RS05385	COG1555	photosystem II stabilization
MGAS27061_RS05390	COG0204	Acyl-transferase
MGAS27061_RS05395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS27061_RS05410	COG0513	Belongs to the DEAD box helicase family
MGAS27061_RS05425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS27061_RS05440	COG0768	penicillin binding
MGAS27061_RS05445	COG2116	formate transmembrane transporter activity
MGAS27061_RS05455	COG1827	regulation of RNA biosynthetic process
MGAS27061_RS05470	COG2217	Heavy metal translocating P-type atpase
MGAS27061_RS05485	COG2755	lipolytic protein G-D-S-L family
MGAS27061_RS05500	COG0497	DNA recombination
MGAS27061_RS05505	COG1438	arginine binding
MGAS27061_RS05510	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS27061_RS05535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS27061_RS05540	COG0415	Belongs to the DNA photolyase family
MGAS27061_RS05550	COG0765	amino acid transport
MGAS27061_RS05555	COG4703	Protein of unknown function (DUF1797)
MGAS27061_RS05560	COG0542	response to heat
MGAS27061_RS05565	COG0494	nUDIX hydrolase
MGAS27061_RS05580	COG3599	regulation of cell shape
MGAS27061_RS05585	COG2302	S4 RNA-binding domain
MGAS27061_RS05635	COG1217	gtp-binding protein TYPA
MGAS27061_RS05640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS27061_RS05645	COG1940	carbohydrate kinase activity
MGAS27061_RS05655	COG0783	Belongs to the Dps family
MGAS27061_RS05670	COG4470	Protein conserved in bacteria
MGAS27061_RS05675	COG1609	Transcriptional regulator
MGAS27061_RS05680	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS27061_RS05690	COG0742	ribosomal rna small subunit methyltransferase
MGAS27061_RS05700	COG0549	Belongs to the carbamate kinase family
MGAS27061_RS05705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS27061_RS05710	COG1288	antiporter activity
MGAS27061_RS05725	COG2235	arginine
MGAS27061_RS05750	COG2972	Histidine kinase
MGAS27061_RS05765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS27061_RS05770	COG0785	Cytochrome C biogenesis protein
MGAS27061_RS05775	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS27061_RS05780	COG1518	maintenance of DNA repeat elements
MGAS27061_RS05840	COG5433	transposase activity
MGAS27061_RS05850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS27061_RS05850	COG1605	Chorismate mutase
MGAS27061_RS05870	COG2226	methyltransferase
MGAS27061_RS05880	COG3250	beta-galactosidase activity
MGAS27061_RS05885	COG2207	Transcriptional regulator
MGAS27061_RS05885	COG4753	response regulator
MGAS27061_RS05890	COG2972	Histidine kinase
MGAS27061_RS05900	COG1653	transport
MGAS27061_RS05905	COG0395	ABC-type sugar transport system, permease component
MGAS27061_RS05910	COG1175	transmembrane transport
MGAS27061_RS05915	COG1940	carbohydrate kinase activity
MGAS27061_RS05920	COG2723	6-phospho-beta-galactosidase activity
MGAS27061_RS05925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS27061_RS05940	COG0383	alpha-mannosidase activity
MGAS27061_RS06030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS27061_RS06035	COG1739	Uncharacterized protein family UPF0029
MGAS27061_RS06045	COG1098	S1 RNA binding domain
MGAS27061_RS06055	COG2197	response regulator
MGAS27061_RS06060	COG4585	Histidine kinase
MGAS27061_RS06070	COG2815	serine threonine protein kinase
MGAS27061_RS06070	COG0515	serine threonine protein kinase
MGAS27061_RS06080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS27061_RS06080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS27061_RS06090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS27061_RS06110	COG0583	DNA-binding transcription factor activity
MGAS27061_RS06115	COG0183	Belongs to the thiolase family
MGAS27061_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27061_RS06135	COG2610	gluconate transmembrane transporter activity
MGAS27061_RS06150	COG0116	Belongs to the methyltransferase superfamily
MGAS27061_RS06175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS27061_RS06180	COG3579	cysteine-type endopeptidase activity
MGAS27061_RS06190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS27061_RS06195	COG1113	amino acid transport
MGAS27061_RS06200	COG0492	ferredoxin-NADP+ reductase activity
MGAS27061_RS06210	COG1126	abc transporter atp-binding protein
MGAS27061_RS06220	COG0513	Belongs to the DEAD box helicase family
MGAS27061_RS06230	COG0768	penicillin binding
MGAS27061_RS06265	COG1131	(ABC) transporter
MGAS27061_RS06290	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS27061_RS06295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS27061_RS06330	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS27061_RS06335	COG0656	L-ascorbic acid biosynthetic process
MGAS27061_RS06345	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS27061_RS06365	COG0561	phosphatase activity
MGAS27061_RS06370	COG2860	membrane
MGAS27061_RS06420	COG2217	Heavy metal translocating P-type atpase
MGAS27061_RS06450	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS27061_RS06455	COG0195	Participates in both transcription termination and antitermination
MGAS27061_RS06480	COG4473	ABC transporter
MGAS27061_RS06485	COG1131	(ABC) transporter
MGAS27061_RS06490	COG0537	adenosine 5'-monophosphoramidase activity
MGAS27061_RS06500	COG1316	TRANSCRIPTIONal
MGAS27061_RS06510	COG0802	atpase or kinase
MGAS27061_RS06515	COG2252	PERMEase
MGAS27061_RS06520	COG0561	phosphatase activity
MGAS27061_RS06530	COG3715	PTS system
MGAS27061_RS06535	COG3716	PTS system mannose fructose sorbose family IID component
MGAS27061_RS06560	COG0439	Biotin carboxylase
MGAS27061_RS06575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS27061_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27061_RS06585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS27061_RS06610	COG1024	Enoyl-CoA hydratase
MGAS27061_RS06645	COG0588	phosphoglycerate mutase activity
MGAS27061_RS06650	COG2261	transglycosylase associated protein
MGAS27061_RS06675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS27061_RS06675	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS27061_RS06680	COG1335	isochorismatase
MGAS27061_RS06690	COG0436	Aminotransferase
MGAS27061_RS06700	COG0561	phosphatase activity
MGAS27061_RS06705	COG0252	asparaginase activity
MGAS27061_RS06720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS27061_RS06725	COG1129	ABC transporter
MGAS27061_RS06740	COG1132	(ABC) transporter
MGAS27061_RS06745	COG4988	ABC transporter
MGAS27061_RS06775	COG3942	CHAP domain
MGAS27061_RS06775	COG1388	LysM domain
MGAS27061_RS06805	COG1482	cell wall glycoprotein biosynthetic process
MGAS27061_RS06810	COG1940	carbohydrate kinase activity
MGAS27061_RS06820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27061_RS06820	COG1263	PTS System
MGAS27061_RS06820	COG2190	(PTS) system
MGAS27061_RS06825	COG1621	beta-fructofuranosidase activity
MGAS27061_RS06830	COG1609	Transcriptional regulator
MGAS27061_RS06850	COG2131	deaminase
MGAS27061_RS06855	COG0006	proline dipeptidase activity
MGAS27061_RS06895	COG1194	a g-specific adenine glycosylase
MGAS27061_RS06905	COG3118	belongs to the thioredoxin family
MGAS27061_RS06935	COG0681	Belongs to the peptidase S26 family
MGAS27061_RS06940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS27061_RS06955	COG1882	Formate acetyltransferase
MGAS27061_RS06960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS27061_RS06975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS27061_RS06980	COG2814	Major facilitator Superfamily
MGAS27061_RS06985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS27061_RS07010	COG0789	Transcriptional regulator
MGAS27061_RS07025	COG2081	HI0933 family
MGAS27061_RS07035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS27061_RS07040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS27061_RS07060	COG0456	acetyltransferase
MGAS27061_RS07065	COG1214	PFAM Peptidase M22, glycoprotease
MGAS27061_RS07080	COG0174	glutamine synthetase
MGAS27061_RS07085	COG0789	Transcriptional regulator
MGAS27061_RS07100	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS27061_RS07155	COG0668	transmembrane transport
MGAS27061_RS07165	COG4720	Psort location CytoplasmicMembrane, score
MGAS27061_RS07170	COG0351	phosphomethylpyrimidine kinase
MGAS27061_RS07220	COG5433	transposase activity
MGAS27061_RS07225	COG1929	Belongs to the glycerate kinase type-1 family
MGAS27061_RS07230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS27061_RS07260	COG0577	efflux transmembrane transporter activity
MGAS27061_RS07265	COG1136	(ABC) transporter
MGAS27061_RS07290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27061_RS07290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27061_RS07295	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS27061_RS07345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS27061_RS07350	COG1476	TRANSCRIPTIONal
MGAS27061_RS07370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS27061_RS07380	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS27061_RS07400	COG1045	serine acetyltransferase
MGAS27061_RS07415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS27061_RS07460	COG1846	Transcriptional regulator
MGAS27061_RS07480	COG4589	Belongs to the CDS family
MGAS27061_RS07490	COG1862	Preprotein translocase
MGAS27061_RS07500	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS27061_RS07510	COG3842	ATPase activity
MGAS27061_RS07550	COG1263	PTS System
MGAS27061_RS07550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27061_RS07550	COG2190	(PTS) system
MGAS27061_RS07555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS27061_RS07570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS27061_RS07575	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS27061_RS07580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS27061_RS07620	COG0601	transmembrane transport
MGAS27061_RS07630	COG1122	ATPase activity
MGAS27061_RS07650	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS27061_RS07680	COG3711	transcriptional antiterminator
MGAS27061_RS07690	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27061_RS07690	COG3942	CHAP domain
MGAS27061_RS07695	COG2205	protein histidine kinase activity
MGAS27061_RS07700	COG0745	RESPONSE REGULATOR receiver
MGAS27061_RS07705	COG0577	efflux transmembrane transporter activity
MGAS27061_RS07710	COG1136	(ABC) transporter
MGAS27061_RS07770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS27061_RS07785	COG1882	Formate acetyltransferase
MGAS27061_RS07790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27061_RS07795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27061_RS07800	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS27061_RS07805	COG2390	Transcriptional regulator
MGAS27061_RS07810	COG1349	DNA-binding transcription factor activity
MGAS27061_RS07815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS27061_RS07825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS27061_RS07840	COG0564	pseudouridine synthase activity
MGAS27061_RS07870	COG0542	response to heat
MGAS27061_RS07875	COG4463	regulation of RNA biosynthetic process
MGAS27061_RS07890	COG0450	alkyl hydroperoxide reductase
MGAS27061_RS07905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS27061_RS07915	COG3404	Formiminotransferase-cyclodeaminase
MGAS27061_RS07930	COG0531	amino acid
MGAS27061_RS07960	COG3590	peptidase
MGAS27061_RS07965	COG0366	Alpha amylase catalytic
MGAS27061_RS07970	COG1263	PTS System
MGAS27061_RS07970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27061_RS07975	COG2188	Transcriptional regulator
MGAS27061_RS07985	COG5433	transposase activity
MGAS27061_RS07990	COG2514	catechol 2,3-dioxygenase activity
MGAS27061_RS08000	COG0602	queuosine metabolic process
MGAS27061_RS08015	COG1328	CTP reductase activity
MGAS27061_RS08040	COG1393	Belongs to the ArsC family
MGAS27061_RS08055	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS27061_RS08100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27061_RS08105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27061_RS08110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27061_RS08195	COG1511	domain protein
MGAS27061_RS08215	COG5433	transposase activity
MGAS27061_RS08225	COG0305	Participates in initiation and elongation during chromosome replication
MGAS27061_RS08255	COG1760	l-serine dehydratase
MGAS27061_RS08260	COG1760	l-serine dehydratase
MGAS27061_RS08265	COG0741	lytic transglycosylase activity
MGAS27061_RS08270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS27061_RS08285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS27061_RS08295	COG0612	Peptidase, M16
MGAS27061_RS08320	COG0517	IMP dehydrogenase activity
MGAS27061_RS08320	COG0516	GMP reductase activity
MGAS27061_RS08330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27061_RS08335	COG0488	(ABC) transporter
MGAS27061_RS08370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS27061_RS08375	COG1475	DNA binding