locus-tag	class	description
MGAS27961_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS27961_RS00020	COG0012	GTP binding
MGAS27961_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS27961_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS27961_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS27961_RS00065	COG0531	amino acid
MGAS27961_RS00245	COG3942	CHAP domain
MGAS27961_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS27961_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS27961_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS27961_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS27961_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS27961_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS27961_RS00355	COG1454	alcohol dehydrogenase
MGAS27961_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
MGAS27961_RS00360	COG1064	alcohol dehydrogenase
MGAS27961_RS00365	COG0534	Mate efflux family protein
MGAS27961_RS00475	COG0201	protein transport
MGAS27961_RS00620	COG1121	(ABC) transporter
MGAS27961_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS27961_RS00640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS27961_RS00660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS27961_RS00665	COG1459	type II secretion system
MGAS27961_RS00670	COG4537	Required for transformation and DNA binding
MGAS27961_RS00710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS27961_RS00715	COG1363	Peptidase, m42
MGAS27961_RS00730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS27961_RS00735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS27961_RS00745	COG1428	Deoxynucleoside kinase
MGAS27961_RS00750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS27961_RS00795	COG4509	Sortase family
MGAS27961_RS00820	COG2031	fatty acid transporter
MGAS27961_RS00835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS27961_RS00850	COG0251	oxidation-reduction process
MGAS27961_RS00865	COG1269	ATP hydrolysis coupled proton transport
MGAS27961_RS00870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS27961_RS00880	COG1527	subunit (C
MGAS27961_RS00885	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS27961_RS00920	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS27961_RS00960	COG0626	cystathionine gamma-synthase activity
MGAS27961_RS00990	COG3623	hexulose-6-phosphate isomerase
MGAS27961_RS01015	COG3448	diguanylate cyclase activity
MGAS27961_RS01015	COG4175	Glycine betaine
MGAS27961_RS01025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS27961_RS01025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS27961_RS01045	COG3969	phosphoadenosine phosphosulfate
MGAS27961_RS01050	COG1475	DNA binding
MGAS27961_RS01100	COG1268	BioY protein
MGAS27961_RS01105	COG1234	tRNA 3'-trailer cleavage
MGAS27961_RS01140	COG0705	Rhomboid family
MGAS27961_RS01140	COG0457	Tetratricopeptide repeat
MGAS27961_RS01160	COG1132	(ABC) transporter
MGAS27961_RS01165	COG1132	(ABC) transporter
MGAS27961_RS01175	COG0756	dUTP diphosphatase activity
MGAS27961_RS01200	COG3290	protein histidine kinase activity
MGAS27961_RS01225	COG1847	R3H domain protein
MGAS27961_RS01245	COG1175	transmembrane transport
MGAS27961_RS01250	COG0395	ABC-type sugar transport system, permease component
MGAS27961_RS01260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS27961_RS01275	COG0084	hydrolase, TatD family'
MGAS27961_RS01300	COG1564	THIamine pyrophosphokinase
MGAS27961_RS01315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS27961_RS01355	COG0765	amino acid transport
MGAS27961_RS01375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS27961_RS01385	COG0719	Fe-S assembly protein
MGAS27961_RS01390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS27961_RS01405	COG1686	Belongs to the peptidase S11 family
MGAS27961_RS01410	COG1686	Belongs to the peptidase S11 family
MGAS27961_RS01415	COG4166	transmembrane transport
MGAS27961_RS01420	COG0601	transmembrane transport
MGAS27961_RS01425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS27961_RS01430	COG0444	Belongs to the ABC transporter superfamily
MGAS27961_RS01485	COG0351	phosphomethylpyrimidine kinase
MGAS27961_RS01490	COG4720	Psort location CytoplasmicMembrane, score
MGAS27961_RS01500	COG0668	transmembrane transport
MGAS27961_RS01555	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS27961_RS01570	COG0789	Transcriptional regulator
MGAS27961_RS01575	COG0174	glutamine synthetase
MGAS27961_RS01590	COG1214	PFAM Peptidase M22, glycoprotease
MGAS27961_RS01595	COG0456	acetyltransferase
MGAS27961_RS01615	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS27961_RS01620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS27961_RS01630	COG2081	HI0933 family
MGAS27961_RS01665	COG0789	Transcriptional regulator
MGAS27961_RS01690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS27961_RS01695	COG2814	Major facilitator Superfamily
MGAS27961_RS01705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS27961_RS01720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS27961_RS01725	COG1882	Formate acetyltransferase
MGAS27961_RS01740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS27961_RS01745	COG0681	Belongs to the peptidase S26 family
MGAS27961_RS01775	COG3118	belongs to the thioredoxin family
MGAS27961_RS01785	COG1194	a g-specific adenine glycosylase
MGAS27961_RS01825	COG0006	proline dipeptidase activity
MGAS27961_RS01830	COG2131	deaminase
MGAS27961_RS01850	COG1609	Transcriptional regulator
MGAS27961_RS01855	COG1621	beta-fructofuranosidase activity
MGAS27961_RS01860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27961_RS01860	COG1263	PTS System
MGAS27961_RS01860	COG2190	(PTS) system
MGAS27961_RS01870	COG1940	carbohydrate kinase activity
MGAS27961_RS01875	COG1482	cell wall glycoprotein biosynthetic process
MGAS27961_RS01895	COG1388	LysM domain
MGAS27961_RS01895	COG3942	CHAP domain
MGAS27961_RS01920	COG1120	ATPase activity
MGAS27961_RS01925	COG1132	(ABC) transporter
MGAS27961_RS01930	COG1132	(ABC) transporter
MGAS27961_RS01945	COG1129	ABC transporter
MGAS27961_RS01955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS27961_RS01970	COG0252	asparaginase activity
MGAS27961_RS01975	COG0561	phosphatase activity
MGAS27961_RS01985	COG0436	Aminotransferase
MGAS27961_RS01995	COG1335	isochorismatase
MGAS27961_RS02030	COG2261	transglycosylase associated protein
MGAS27961_RS02035	COG0588	phosphoglycerate mutase activity
MGAS27961_RS02070	COG1024	Enoyl-CoA hydratase
MGAS27961_RS02095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS27961_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27961_RS02105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS27961_RS02120	COG0439	Biotin carboxylase
MGAS27961_RS02145	COG3716	PTS system mannose fructose sorbose family IID component
MGAS27961_RS02150	COG3715	PTS system
MGAS27961_RS02160	COG0561	phosphatase activity
MGAS27961_RS02165	COG2252	PERMEase
MGAS27961_RS02170	COG0802	atpase or kinase
MGAS27961_RS02180	COG1316	TRANSCRIPTIONal
MGAS27961_RS02190	COG0537	adenosine 5'-monophosphoramidase activity
MGAS27961_RS02195	COG1131	(ABC) transporter
MGAS27961_RS02200	COG4473	ABC transporter
MGAS27961_RS02225	COG0195	Participates in both transcription termination and antitermination
MGAS27961_RS02230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS27961_RS02260	COG2217	Heavy metal translocating P-type atpase
MGAS27961_RS02315	COG2860	membrane
MGAS27961_RS02320	COG0561	phosphatase activity
MGAS27961_RS02340	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS27961_RS02350	COG0656	L-ascorbic acid biosynthetic process
MGAS27961_RS02355	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS27961_RS02395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS27961_RS02400	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS27961_RS02425	COG1131	(ABC) transporter
MGAS27961_RS02460	COG0768	penicillin binding
MGAS27961_RS02470	COG0513	Belongs to the DEAD box helicase family
MGAS27961_RS02480	COG1126	abc transporter atp-binding protein
MGAS27961_RS02490	COG0492	ferredoxin-NADP+ reductase activity
MGAS27961_RS02495	COG1113	amino acid transport
MGAS27961_RS02500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS27961_RS02510	COG3579	cysteine-type endopeptidase activity
MGAS27961_RS02515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS27961_RS02540	COG0116	Belongs to the methyltransferase superfamily
MGAS27961_RS02555	COG2610	gluconate transmembrane transporter activity
MGAS27961_RS02560	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27961_RS02570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS27961_RS02575	COG0183	Belongs to the thiolase family
MGAS27961_RS02580	COG0583	DNA-binding transcription factor activity
MGAS27961_RS02600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS27961_RS02610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS27961_RS02610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS27961_RS02620	COG0515	serine threonine protein kinase
MGAS27961_RS02620	COG2815	serine threonine protein kinase
MGAS27961_RS02630	COG4585	Histidine kinase
MGAS27961_RS02635	COG2197	response regulator
MGAS27961_RS02645	COG1098	S1 RNA binding domain
MGAS27961_RS02655	COG1739	Uncharacterized protein family UPF0029
MGAS27961_RS02660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS27961_RS02770	COG0383	alpha-mannosidase activity
MGAS27961_RS02780	COG1609	Transcriptional regulator
MGAS27961_RS02785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS27961_RS02790	COG2723	6-phospho-beta-galactosidase activity
MGAS27961_RS02800	COG1175	transmembrane transport
MGAS27961_RS02805	COG0395	ABC-type sugar transport system, permease component
MGAS27961_RS02810	COG1653	transport
MGAS27961_RS02820	COG2972	Histidine kinase
MGAS27961_RS02825	COG2207	Transcriptional regulator
MGAS27961_RS02825	COG4753	response regulator
MGAS27961_RS02830	COG3250	beta-galactosidase activity
MGAS27961_RS02840	COG2226	methyltransferase
MGAS27961_RS02860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS27961_RS02860	COG1605	Chorismate mutase
MGAS27961_RS02900	COG1396	sequence-specific DNA binding
MGAS27961_RS02940	COG1674	ftsk spoiiie
MGAS27961_RS02990	COG0433	COG0433 Predicted ATPase
MGAS27961_RS03045	COG5433	transposase activity
MGAS27961_RS03105	COG1518	maintenance of DNA repeat elements
MGAS27961_RS03110	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS27961_RS03115	COG0785	Cytochrome C biogenesis protein
MGAS27961_RS03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS27961_RS03135	COG2972	Histidine kinase
MGAS27961_RS03160	COG2235	arginine
MGAS27961_RS03175	COG1288	antiporter activity
MGAS27961_RS03180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS27961_RS03185	COG0549	Belongs to the carbamate kinase family
MGAS27961_RS03195	COG0742	ribosomal rna small subunit methyltransferase
MGAS27961_RS03205	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS27961_RS03210	COG1609	Transcriptional regulator
MGAS27961_RS03215	COG4470	Protein conserved in bacteria
MGAS27961_RS03230	COG0783	Belongs to the Dps family
MGAS27961_RS03240	COG1940	carbohydrate kinase activity
MGAS27961_RS03245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS27961_RS03250	COG1217	gtp-binding protein TYPA
MGAS27961_RS03285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS27961_RS03300	COG2302	S4 RNA-binding domain
MGAS27961_RS03305	COG3599	regulation of cell shape
MGAS27961_RS03320	COG0494	nUDIX hydrolase
MGAS27961_RS03325	COG0542	response to heat
MGAS27961_RS03330	COG4703	Protein of unknown function (DUF1797)
MGAS27961_RS03335	COG0765	amino acid transport
MGAS27961_RS03345	COG0415	Belongs to the DNA photolyase family
MGAS27961_RS03350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS27961_RS03375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS27961_RS03380	COG1438	arginine binding
MGAS27961_RS03385	COG0497	DNA recombination
MGAS27961_RS03400	COG2755	lipolytic protein G-D-S-L family
MGAS27961_RS03415	COG2217	Heavy metal translocating P-type atpase
MGAS27961_RS03430	COG1827	regulation of RNA biosynthetic process
MGAS27961_RS03440	COG2116	formate transmembrane transporter activity
MGAS27961_RS03445	COG0768	penicillin binding
MGAS27961_RS03460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS27961_RS03480	COG0513	Belongs to the DEAD box helicase family
MGAS27961_RS03495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS27961_RS03500	COG0204	Acyl-transferase
MGAS27961_RS03505	COG1555	photosystem II stabilization
MGAS27961_RS03505	COG1596	polysaccharide export
MGAS27961_RS03555	COG1187	pseudouridine synthase activity
MGAS27961_RS03570	COG2223	nitrite transmembrane transporter activity
MGAS27961_RS03575	COG4122	O-methyltransferase activity
MGAS27961_RS03590	COG1476	TRANSCRIPTIONal
MGAS27961_RS03620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS27961_RS03625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS27961_RS03645	COG0726	polysaccharide deacetylase
MGAS27961_RS03650	COG0513	Belongs to the DEAD box helicase family
MGAS27961_RS03670	COG1956	GAF domain-containing protein
MGAS27961_RS03675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS27961_RS03680	COG5433	transposase activity
MGAS27961_RS03690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS27961_RS03690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS27961_RS03715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MGAS27961_RS03720	COG4109	DRTGG domain
MGAS27961_RS03835	COG2814	Major facilitator Superfamily
MGAS27961_RS03845	COG1187	pseudouridine synthase activity
MGAS27961_RS03875	COG2723	6-phospho-beta-galactosidase activity
MGAS27961_RS03885	COG3711	transcriptional antiterminator
MGAS27961_RS03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS27961_RS03895	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS27961_RS03905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27961_RS03910	COG1126	abc transporter atp-binding protein
MGAS27961_RS03915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27961_RS03935	COG1696	Membrane protein involved in D-alanine export
MGAS27961_RS03945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS27961_RS03950	COG0657	acetylesterase activity
MGAS27961_RS03960	COG2182	Extracellular solute-binding protein
MGAS27961_RS03965	COG0366	Alpha amylase catalytic
MGAS27961_RS03975	COG1175	transmembrane transport
MGAS27961_RS03980	COG3833	ABC-type maltose transport systems, permease component
MGAS27961_RS03995	COG3833	ABC-type maltose transport systems, permease component
MGAS27961_RS04000	COG1175	transmembrane transport
MGAS27961_RS04005	COG2182	Extracellular solute-binding protein
MGAS27961_RS04010	COG1609	Transcriptional regulator
MGAS27961_RS04015	COG1640	4-alpha-glucanotransferase
MGAS27961_RS04020	COG0058	SHG alpha-glucan phosphorylase activity
MGAS27961_RS04205	COG1598	PFAM Uncharacterised protein family UPF0150
MGAS27961_RS04390	COG1131	(ABC) transporter
MGAS27961_RS04395	COG1725	Transcriptional regulator
MGAS27961_RS04410	COG0469	pyruvate kinase activity
MGAS27961_RS04425	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS27961_RS04430	COG0765	amino acid transport
MGAS27961_RS04435	COG1126	abc transporter atp-binding protein
MGAS27961_RS04440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27961_RS04450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS27961_RS04455	COG1115	amino acid carrier protein
MGAS27961_RS04505	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS27961_RS04505	COG1136	(ABC) transporter
MGAS27961_RS04535	COG0196	riboflavin kinase activity
MGAS27961_RS04550	COG0483	inositol monophosphate 1-phosphatase activity
MGAS27961_RS04555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS27961_RS04555	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS27961_RS04565	COG0573	inorganic phosphate transmembrane transporter activity
MGAS27961_RS04570	COG0581	inorganic phosphate transmembrane transporter activity
MGAS27961_RS04585	COG0704	Plays a role in the regulation of phosphate uptake
MGAS27961_RS04600	COG0745	RESPONSE REGULATOR receiver
MGAS27961_RS04605	COG5002	protein histidine kinase activity
MGAS27961_RS04620	COG2813	Specifically methylates the guanine in position
MGAS27961_RS04625	COG0295	cytidine deaminase activity
MGAS27961_RS04630	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS27961_RS04635	COG3845	ABC transporter
MGAS27961_RS04640	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS27961_RS04645	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS27961_RS04650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS27961_RS04655	COG4684	Psort location CytoplasmicMembrane, score
MGAS27961_RS04660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS27961_RS04680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS27961_RS04710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS27961_RS04715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS27961_RS04715	COG1328	CTP reductase activity
MGAS27961_RS04720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS27961_RS04725	COG0351	phosphomethylpyrimidine kinase
MGAS27961_RS04725	COG0352	thiamine-phosphate diphosphorylase activity
MGAS27961_RS04735	COG0488	(ABC) transporter
MGAS27961_RS04755	COG2188	Transcriptional regulator
MGAS27961_RS04765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS27961_RS04785	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS27961_RS04815	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS27961_RS04820	COG0511	ligase activity, forming carbon-carbon bonds
MGAS27961_RS04830	COG2851	Citrate transporter
MGAS27961_RS04845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MGAS27961_RS04850	COG0511	ligase activity, forming carbon-carbon bonds
MGAS27961_RS04900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS27961_RS04905	COG0758	DNA mediated transformation
MGAS27961_RS04925	COG1272	protein, Hemolysin III
MGAS27961_RS04930	COG1597	lipid kinase activity
MGAS27961_RS04945	COG0346	lactoylglutathione lyase activity
MGAS27961_RS04950	COG3764	Sortase (surface protein transpeptidase)
MGAS27961_RS04970	COG1132	(ABC) transporter
MGAS27961_RS04975	COG1132	(ABC) transporter
MGAS27961_RS05005	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS27961_RS05030	COG2233	PERMEase
MGAS27961_RS05050	COG1174	glycine betaine transport
MGAS27961_RS05065	COG4221	oxidoreductase activity
MGAS27961_RS05070	COG0280	phosphate acetyltransferase
MGAS27961_RS05075	COG0564	pseudouridine synthase activity
MGAS27961_RS05085	COG2357	RelA SpoT domain protein
MGAS27961_RS05100	COG1104	cysteine desulfurase activity
MGAS27961_RS05115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS27961_RS05125	COG0628	permease
MGAS27961_RS05135	COG0038	chloride channel
MGAS27961_RS05140	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS27961_RS05145	COG1063	alcohol dehydrogenase
MGAS27961_RS05155	COG3493	citrate carrier protein
MGAS27961_RS05160	COG3290	protein histidine kinase activity
MGAS27961_RS05165	COG4565	transcriptional regulatory protein
MGAS27961_RS05175	COG1177	transmembrane transport
MGAS27961_RS05180	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS27961_RS05195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS27961_RS05215	COG0285	dihydrofolate synthase activity
MGAS27961_RS05245	COG1396	sequence-specific DNA binding
MGAS27961_RS05260	COG1131	(ABC) transporter
MGAS27961_RS05335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS27961_RS05350	COG1012	belongs to the aldehyde dehydrogenase family
MGAS27961_RS05360	COG2207	Transcriptional regulator
MGAS27961_RS05360	COG4753	response regulator
MGAS27961_RS05365	COG2972	Histidine kinase
MGAS27961_RS05370	COG3716	PTS system mannose fructose sorbose family IID component
MGAS27961_RS05375	COG3715	PTS system
MGAS27961_RS05420	COG5433	transposase activity
MGAS27961_RS05430	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS27961_RS05435	COG1518	maintenance of DNA repeat elements
MGAS27961_RS05450	COG0647	UMP catabolic process
MGAS27961_RS05460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS27961_RS05480	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS27961_RS05485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS27961_RS05490	COG3442	glutamine amidotransferase
MGAS27961_RS05495	COG0095	Lipoate-protein ligase
MGAS27961_RS05500	COG5492	domain, Protein
MGAS27961_RS05520	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS27961_RS05525	COG0022	dehydrogenase e1 component
MGAS27961_RS05525	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS27961_RS05530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS27961_RS05535	COG0488	(ABC) transporter
MGAS27961_RS05555	COG1129	ABC transporter
MGAS27961_RS05575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS27961_RS05580	COG0457	Tetratricopeptide repeat
MGAS27961_RS05585	COG0628	permease
MGAS27961_RS05590	COG1051	belongs to the nudix hydrolase family
MGAS27961_RS05595	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS27961_RS05605	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS27961_RS05610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS27961_RS05620	COG2384	SAM-dependent methyltransferase
MGAS27961_RS05625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS27961_RS05640	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MGAS27961_RS05640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MGAS27961_RS05645	COG0300	oxidoreductase activity
MGAS27961_RS05655	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS27961_RS05660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS27961_RS05705	COG0539	negative regulation of cytoplasmic translation
MGAS27961_RS05725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS27961_RS05735	COG0187	DNA topoisomerase II activity
MGAS27961_RS05755	COG0765	amino acid transport
MGAS27961_RS05760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27961_RS05785	COG0583	DNA-binding transcription factor activity
MGAS27961_RS05800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MGAS27961_RS05845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS27961_RS05855	COG3425	synthase
MGAS27961_RS05890	COG0745	RESPONSE REGULATOR receiver
MGAS27961_RS05895	COG2357	RelA SpoT domain protein
MGAS27961_RS05900	COG0737	Belongs to the 5'-nucleotidase family
MGAS27961_RS05905	COG0242	peptide deformylase activity
MGAS27961_RS05915	COG0488	(ABC) transporter
MGAS27961_RS05935	COG0105	UTP biosynthetic process
MGAS27961_RS05955	COG1388	LysM domain
MGAS27961_RS05955	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27961_RS05960	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27961_RS05960	COG1388	LysM domain
MGAS27961_RS05965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS27961_RS05965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS27961_RS05965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS27961_RS05970	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS27961_RS05975	COG1349	DNA-binding transcription factor activity
MGAS27961_RS06025	COG1837	Belongs to the UPF0109 family
MGAS27961_RS06035	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS27961_RS06040	COG0577	efflux transmembrane transporter activity
MGAS27961_RS06045	COG1136	(ABC) transporter
MGAS27961_RS06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS27961_RS06085	COG0564	pseudouridine synthase activity
MGAS27961_RS06095	COG0583	DNA-binding transcription factor activity
MGAS27961_RS06105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS27961_RS06130	COG1104	cysteine desulfurase activity
MGAS27961_RS06140	COG0285	dihydrofolate synthase activity
MGAS27961_RS06145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS27961_RS06165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS27961_RS06170	COG1368	sulfuric ester hydrolase activity
MGAS27961_RS06230	COG1216	Glycosyl transferase, family 2
MGAS27961_RS06275	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS27961_RS06280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS27961_RS06285	COG0358	DNA primase activity
MGAS27961_RS06290	COG1970	mechanosensitive ion channel activity
MGAS27961_RS06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27961_RS06315	COG2321	neutral zinc metallopeptidase
MGAS27961_RS06325	COG0577	efflux transmembrane transporter activity
MGAS27961_RS06410	COG1597	lipid kinase activity
MGAS27961_RS06420	COG4708	membrane
MGAS27961_RS06445	COG1131	(ABC) transporter
MGAS27961_RS06540	COG0038	chloride channel
MGAS27961_RS06550	COG0716	FMN binding
MGAS27961_RS06555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS27961_RS06565	COG2222	sugar isomerase
MGAS27961_RS06570	COG2188	Transcriptional regulator
MGAS27961_RS06605	COG0436	Aminotransferase
MGAS27961_RS06610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS27961_RS06610	COG1199	ATP-dependent helicase activity
MGAS27961_RS06625	COG2177	Part of the ABC transporter FtsEX involved in
MGAS27961_RS06630	COG2884	Cell division ATP-binding protein ftsE
MGAS27961_RS06640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS27961_RS06650	COG0546	phosphoglycolate phosphatase activity
MGAS27961_RS06655	COG0800	Aldolase
MGAS27961_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27961_RS06685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27961_RS06690	COG3715	PTS system
MGAS27961_RS06695	COG3716	PTS system mannose fructose sorbose family IID component
MGAS27961_RS06705	COG1609	Transcriptional regulator
MGAS27961_RS06720	COG1078	dGTPase activity
MGAS27961_RS06755	COG0772	Belongs to the SEDS family
MGAS27961_RS06765	COG1164	Oligoendopeptidase f
MGAS27961_RS06770	COG0386	Belongs to the glutathione peroxidase family
MGAS27961_RS06815	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS27961_RS06820	COG0826	peptidase U32
MGAS27961_RS06865	COG2183	response to ionizing radiation
MGAS27961_RS06875	COG0701	Predicted permease
MGAS27961_RS06880	COG3689	TIGRFAM TIGR03943 family protein
MGAS27961_RS06890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27961_RS06890	COG2190	(PTS) system
MGAS27961_RS06890	COG1263	PTS System
MGAS27961_RS06895	COG3711	transcriptional antiterminator
MGAS27961_RS06900	COG0477	Major facilitator Superfamily
MGAS27961_RS06905	COG0552	protein localization to endoplasmic reticulum
MGAS27961_RS06910	COG0561	phosphatase activity
MGAS27961_RS06915	COG0561	phosphatase activity
MGAS27961_RS07010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS27961_RS07020	COG1196	nuclear chromosome segregation
MGAS27961_RS07030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS27961_RS07035	COG5002	protein histidine kinase activity
MGAS27961_RS07040	COG0745	RESPONSE REGULATOR receiver
MGAS27961_RS07055	COG0183	Belongs to the thiolase family
MGAS27961_RS07075	COG4555	ABC transporter
MGAS27961_RS07085	COG0438	transferase activity, transferring glycosyl groups
MGAS27961_RS07095	COG1609	Transcriptional regulator
MGAS27961_RS07100	COG0006	proline dipeptidase activity
MGAS27961_RS07105	COG0778	Nitroreductase
MGAS27961_RS07115	COG0463	Glycosyl transferase, family 2
MGAS27961_RS07145	COG0557	exoribonuclease II activity
MGAS27961_RS07160	COG2814	Major facilitator Superfamily
MGAS27961_RS07165	COG0433	COG0433 Predicted ATPase
MGAS27961_RS07265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS27961_RS07275	COG1573	uracil-dna glycosylase
MGAS27961_RS07280	COG1702	phosphate starvation-inducible protein PhoH
MGAS27961_RS07370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS27961_RS07380	COG0494	nUDIX hydrolase
MGAS27961_RS07395	COG0673	inositol 2-dehydrogenase activity
MGAS27961_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS27961_RS07500	COG1304	FMN binding
MGAS27961_RS07510	COG0708	Exodeoxyribonuclease III
MGAS27961_RS07515	COG1393	Belongs to the ArsC family
MGAS27961_RS07540	COG0470	DNA polymerase III
MGAS27961_RS07570	COG2244	polysaccharide biosynthetic process
MGAS27961_RS07580	COG1120	ATPase activity
MGAS27961_RS07585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS27961_RS07590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS27961_RS07595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS27961_RS07610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS27961_RS07615	COG1253	flavin adenine dinucleotide binding
MGAS27961_RS07620	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS27961_RS07625	COG1242	4 iron, 4 sulfur cluster binding
MGAS27961_RS07630	COG0671	phosphoesterase, PA-phosphatase related
MGAS27961_RS07635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS27961_RS07650	COG1187	pseudouridine synthase activity
MGAS27961_RS07705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS27961_RS07710	COG1254	Belongs to the acylphosphatase family
MGAS27961_RS07725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS27961_RS07745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS27961_RS07755	COG1484	DNA-dependent DNA replication
MGAS27961_RS07775	COG0745	RESPONSE REGULATOR receiver
MGAS27961_RS07790	COG1704	LemA family
MGAS27961_RS07800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS27961_RS07805	COG0569	domain protein
MGAS27961_RS07815	COG1114	Component of the transport system for branched-chain amino acids
MGAS27961_RS07830	COG1464	Belongs to the NlpA lipoprotein family
MGAS27961_RS07835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS27961_RS07855	COG2226	methyltransferase
MGAS27961_RS07860	COG0799	negative regulation of ribosome biogenesis
MGAS27961_RS07865	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS27961_RS07875	COG1534	Rna-binding protein
MGAS27961_RS07880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS27961_RS07885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS27961_RS07925	COG1929	Belongs to the glycerate kinase type-1 family
MGAS27961_RS07930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS27961_RS07960	COG0577	efflux transmembrane transporter activity
MGAS27961_RS07965	COG1136	(ABC) transporter
MGAS27961_RS07990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27961_RS07990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27961_RS07995	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS27961_RS08045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS27961_RS08050	COG1476	TRANSCRIPTIONal
MGAS27961_RS08070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS27961_RS08080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS27961_RS08100	COG1045	serine acetyltransferase
MGAS27961_RS08115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS27961_RS08130	COG3711	transcriptional antiterminator
MGAS27961_RS08155	COG0431	NADPH-dependent FMN reductase
MGAS27961_RS08160	COG1846	Transcriptional regulator
MGAS27961_RS08180	COG4589	Belongs to the CDS family
MGAS27961_RS08190	COG1862	Preprotein translocase
MGAS27961_RS08200	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS27961_RS08215	COG3842	ATPase activity
MGAS27961_RS08255	COG2190	(PTS) system
MGAS27961_RS08255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27961_RS08255	COG1263	PTS System
MGAS27961_RS08260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS27961_RS08275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS27961_RS08280	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS27961_RS08285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS27961_RS08320	COG0601	transmembrane transport
MGAS27961_RS08330	COG1122	ATPase activity
MGAS27961_RS08350	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS27961_RS08355	COG5433	transposase activity
MGAS27961_RS08390	COG3711	transcriptional antiterminator
MGAS27961_RS08405	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS27961_RS08405	COG3942	CHAP domain
MGAS27961_RS08410	COG2205	protein histidine kinase activity
MGAS27961_RS08415	COG0745	RESPONSE REGULATOR receiver
MGAS27961_RS08420	COG0577	efflux transmembrane transporter activity
MGAS27961_RS08425	COG1136	(ABC) transporter
MGAS27961_RS08500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS27961_RS08515	COG1882	Formate acetyltransferase
MGAS27961_RS08520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27961_RS08525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS27961_RS08530	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS27961_RS08535	COG2390	Transcriptional regulator
MGAS27961_RS08540	COG1349	DNA-binding transcription factor activity
MGAS27961_RS08545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS27961_RS08565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS27961_RS08580	COG0564	pseudouridine synthase activity
MGAS27961_RS08615	COG0542	response to heat
MGAS27961_RS08620	COG4463	regulation of RNA biosynthetic process
MGAS27961_RS08635	COG0450	alkyl hydroperoxide reductase
MGAS27961_RS08650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS27961_RS08660	COG3404	Formiminotransferase-cyclodeaminase
MGAS27961_RS08675	COG0531	amino acid
MGAS27961_RS08705	COG3590	peptidase
MGAS27961_RS08710	COG0366	Alpha amylase catalytic
MGAS27961_RS08715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS27961_RS08715	COG1263	PTS System
MGAS27961_RS08720	COG2188	Transcriptional regulator
MGAS27961_RS08735	COG2514	catechol 2,3-dioxygenase activity
MGAS27961_RS08745	COG0602	queuosine metabolic process
MGAS27961_RS08760	COG1328	CTP reductase activity
MGAS27961_RS08785	COG1393	Belongs to the ArsC family
MGAS27961_RS08800	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS27961_RS08820	COG0582	viral genome integration into host DNA
MGAS27961_RS08990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27961_RS08995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27961_RS09000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27961_RS09085	COG1511	domain protein
MGAS27961_RS09205	COG0582	viral genome integration into host DNA
MGAS27961_RS09220	COG0305	Participates in initiation and elongation during chromosome replication
MGAS27961_RS09250	COG1760	l-serine dehydratase
MGAS27961_RS09255	COG1760	l-serine dehydratase
MGAS27961_RS09260	COG0741	lytic transglycosylase activity
MGAS27961_RS09265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS27961_RS09280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS27961_RS09290	COG0612	Peptidase, M16
MGAS27961_RS09315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MGAS27961_RS09335	COG0516	GMP reductase activity
MGAS27961_RS09335	COG0517	IMP dehydrogenase activity
MGAS27961_RS09345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS27961_RS09350	COG0488	(ABC) transporter
MGAS27961_RS09385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS27961_RS09390	COG1475	DNA binding