locus-tag	class	description
SPYM3_RS00010	COG0592	DNA-directed DNA polymerase activity
SPYM3_RS00020	COG0012	GTP binding
SPYM3_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYM3_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYM3_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYM3_RS00065	COG0531	amino acid
SPYM3_RS00240	COG3942	CHAP domain
SPYM3_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYM3_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYM3_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYM3_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYM3_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYM3_RS00335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYM3_RS00350	COG1454	alcohol dehydrogenase
SPYM3_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
SPYM3_RS00355	COG1064	alcohol dehydrogenase
SPYM3_RS00360	COG0534	Mate efflux family protein
SPYM3_RS00470	COG0201	protein transport
SPYM3_RS00605	COG1121	(ABC) transporter
SPYM3_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYM3_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM3_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYM3_RS00650	COG1459	type II secretion system
SPYM3_RS00655	COG4537	Required for transformation and DNA binding
SPYM3_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYM3_RS00700	COG1363	Peptidase, m42
SPYM3_RS00710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYM3_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYM3_RS00730	COG1428	Deoxynucleoside kinase
SPYM3_RS00735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYM3_RS00765	COG4509	Sortase family
SPYM3_RS00790	COG2031	fatty acid transporter
SPYM3_RS00805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYM3_RS00820	COG0251	oxidation-reduction process
SPYM3_RS00835	COG1269	ATP hydrolysis coupled proton transport
SPYM3_RS00840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYM3_RS00850	COG1527	subunit (C
SPYM3_RS00855	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYM3_RS00890	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYM3_RS00925	COG0626	cystathionine gamma-synthase activity
SPYM3_RS00955	COG3623	hexulose-6-phosphate isomerase
SPYM3_RS00975	COG4175	Glycine betaine
SPYM3_RS00975	COG3448	diguanylate cyclase activity
SPYM3_RS00985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYM3_RS00985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYM3_RS01010	COG1268	BioY protein
SPYM3_RS01015	COG1234	tRNA 3'-trailer cleavage
SPYM3_RS01050	COG0705	Rhomboid family
SPYM3_RS01050	COG0457	Tetratricopeptide repeat
SPYM3_RS01070	COG1132	(ABC) transporter
SPYM3_RS01075	COG1132	(ABC) transporter
SPYM3_RS01085	COG0756	dUTP diphosphatase activity
SPYM3_RS01110	COG3290	protein histidine kinase activity
SPYM3_RS01135	COG1847	R3H domain protein
SPYM3_RS01160	COG1175	transmembrane transport
SPYM3_RS01165	COG0395	ABC-type sugar transport system, permease component
SPYM3_RS01175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYM3_RS01190	COG0084	hydrolase, TatD family'
SPYM3_RS01215	COG1564	THIamine pyrophosphokinase
SPYM3_RS01230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYM3_RS01265	COG0765	amino acid transport
SPYM3_RS01285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYM3_RS01295	COG0719	Fe-S assembly protein
SPYM3_RS01300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYM3_RS01315	COG1686	Belongs to the peptidase S11 family
SPYM3_RS01320	COG1686	Belongs to the peptidase S11 family
SPYM3_RS01325	COG4166	transmembrane transport
SPYM3_RS01330	COG0601	transmembrane transport
SPYM3_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYM3_RS01340	COG0444	Belongs to the ABC transporter superfamily
SPYM3_RS01400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYM3_RS01405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYM3_RS01410	COG1534	Rna-binding protein
SPYM3_RS01420	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYM3_RS01425	COG0799	negative regulation of ribosome biogenesis
SPYM3_RS01430	COG2226	methyltransferase
SPYM3_RS01445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM3_RS01450	COG1464	Belongs to the NlpA lipoprotein family
SPYM3_RS01465	COG1114	Component of the transport system for branched-chain amino acids
SPYM3_RS01475	COG0569	domain protein
SPYM3_RS01480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYM3_RS01490	COG1704	LemA family
SPYM3_RS01505	COG0745	RESPONSE REGULATOR receiver
SPYM3_RS01525	COG1484	DNA-dependent DNA replication
SPYM3_RS01535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYM3_RS01555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYM3_RS01570	COG1254	Belongs to the acylphosphatase family
SPYM3_RS01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYM3_RS01630	COG1187	pseudouridine synthase activity
SPYM3_RS01645	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYM3_RS01650	COG0671	phosphoesterase, PA-phosphatase related
SPYM3_RS01655	COG1242	4 iron, 4 sulfur cluster binding
SPYM3_RS01660	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYM3_RS01665	COG1253	flavin adenine dinucleotide binding
SPYM3_RS01670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYM3_RS01685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYM3_RS01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYM3_RS01695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYM3_RS01700	COG1120	ATPase activity
SPYM3_RS01710	COG2244	polysaccharide biosynthetic process
SPYM3_RS01735	COG0470	DNA polymerase III
SPYM3_RS01770	COG1393	Belongs to the ArsC family
SPYM3_RS01775	COG0708	Exodeoxyribonuclease III
SPYM3_RS01785	COG1304	FMN binding
SPYM3_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM3_RS01850	COG0673	inositol 2-dehydrogenase activity
SPYM3_RS01865	COG0494	nUDIX hydrolase
SPYM3_RS01875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYM3_RS01965	COG1702	phosphate starvation-inducible protein PhoH
SPYM3_RS01970	COG1573	uracil-dna glycosylase
SPYM3_RS01980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYM3_RS02060	COG0433	COG0433 Predicted ATPase
SPYM3_RS02065	COG2814	Major facilitator Superfamily
SPYM3_RS02075	COG0557	exoribonuclease II activity
SPYM3_RS02105	COG0463	Glycosyl transferase, family 2
SPYM3_RS02115	COG0778	Nitroreductase
SPYM3_RS02120	COG0006	proline dipeptidase activity
SPYM3_RS02125	COG1609	Transcriptional regulator
SPYM3_RS02135	COG0438	transferase activity, transferring glycosyl groups
SPYM3_RS02145	COG4555	ABC transporter
SPYM3_RS02165	COG0183	Belongs to the thiolase family
SPYM3_RS02180	COG0745	RESPONSE REGULATOR receiver
SPYM3_RS02185	COG5002	protein histidine kinase activity
SPYM3_RS02190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYM3_RS02200	COG1196	nuclear chromosome segregation
SPYM3_RS02210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYM3_RS02320	COG0561	phosphatase activity
SPYM3_RS02325	COG0561	phosphatase activity
SPYM3_RS02330	COG0552	protein localization to endoplasmic reticulum
SPYM3_RS02335	COG0477	Major facilitator Superfamily
SPYM3_RS02340	COG3711	transcriptional antiterminator
SPYM3_RS02345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM3_RS02345	COG2190	(PTS) system
SPYM3_RS02345	COG1263	PTS System
SPYM3_RS02355	COG3689	TIGRFAM TIGR03943 family protein
SPYM3_RS02360	COG0701	Predicted permease
SPYM3_RS02370	COG2183	response to ionizing radiation
SPYM3_RS02415	COG0826	peptidase U32
SPYM3_RS02420	COG4443	Transcriptional Coactivator p15 (PC4)
SPYM3_RS02470	COG0386	Belongs to the glutathione peroxidase family
SPYM3_RS02475	COG1164	Oligoendopeptidase f
SPYM3_RS02485	COG0772	Belongs to the SEDS family
SPYM3_RS02520	COG1078	dGTPase activity
SPYM3_RS02535	COG1609	Transcriptional regulator
SPYM3_RS02545	COG3716	PTS system mannose fructose sorbose family IID component
SPYM3_RS02550	COG3715	PTS system
SPYM3_RS02555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM3_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM3_RS02585	COG0800	Aldolase
SPYM3_RS02590	COG0546	phosphoglycolate phosphatase activity
SPYM3_RS02595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYM3_RS02605	COG2884	Cell division ATP-binding protein ftsE
SPYM3_RS02610	COG2177	Part of the ABC transporter FtsEX involved in
SPYM3_RS02625	COG1199	ATP-dependent helicase activity
SPYM3_RS02625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYM3_RS02630	COG0436	Aminotransferase
SPYM3_RS02665	COG2188	Transcriptional regulator
SPYM3_RS02670	COG2222	sugar isomerase
SPYM3_RS02680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYM3_RS02685	COG0716	FMN binding
SPYM3_RS02695	COG0038	chloride channel
SPYM3_RS02765	COG1131	(ABC) transporter
SPYM3_RS02785	COG4708	membrane
SPYM3_RS02795	COG1597	lipid kinase activity
SPYM3_RS02880	COG0577	efflux transmembrane transporter activity
SPYM3_RS02905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM3_RS02915	COG1970	mechanosensitive ion channel activity
SPYM3_RS02920	COG0358	DNA primase activity
SPYM3_RS02925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYM3_RS02930	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYM3_RS02975	COG1216	Glycosyl transferase, family 2
SPYM3_RS03030	COG1368	sulfuric ester hydrolase activity
SPYM3_RS03035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYM3_RS03055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYM3_RS03060	COG0285	dihydrofolate synthase activity
SPYM3_RS03070	COG1104	cysteine desulfurase activity
SPYM3_RS03095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYM3_RS03100	COG0583	DNA-binding transcription factor activity
SPYM3_RS03110	COG0564	pseudouridine synthase activity
SPYM3_RS03140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYM3_RS03145	COG1136	(ABC) transporter
SPYM3_RS03150	COG0577	efflux transmembrane transporter activity
SPYM3_RS03155	COG0584	glycerophosphoryl diester phosphodiesterase
SPYM3_RS03165	COG1837	Belongs to the UPF0109 family
SPYM3_RS03215	COG1349	DNA-binding transcription factor activity
SPYM3_RS03220	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYM3_RS03225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYM3_RS03225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYM3_RS03225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYM3_RS03230	COG1388	LysM domain
SPYM3_RS03230	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM3_RS03235	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM3_RS03235	COG1388	LysM domain
SPYM3_RS03250	COG0105	UTP biosynthetic process
SPYM3_RS03270	COG0488	(ABC) transporter
SPYM3_RS03280	COG0242	peptide deformylase activity
SPYM3_RS03285	COG0737	Belongs to the 5'-nucleotidase family
SPYM3_RS03290	COG2357	RelA SpoT domain protein
SPYM3_RS03295	COG0745	RESPONSE REGULATOR receiver
SPYM3_RS03330	COG3425	synthase
SPYM3_RS03340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYM3_RS03400	COG0583	DNA-binding transcription factor activity
SPYM3_RS03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM3_RS03430	COG0765	amino acid transport
SPYM3_RS03450	COG0187	DNA topoisomerase II activity
SPYM3_RS03460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYM3_RS03480	COG0539	negative regulation of cytoplasmic translation
SPYM3_RS03515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYM3_RS03520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYM3_RS03530	COG0300	oxidoreductase activity
SPYM3_RS03535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYM3_RS03535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYM3_RS03550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYM3_RS03555	COG2384	SAM-dependent methyltransferase
SPYM3_RS03565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYM3_RS03570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYM3_RS03580	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYM3_RS03585	COG1051	belongs to the nudix hydrolase family
SPYM3_RS03590	COG0628	permease
SPYM3_RS03595	COG0457	Tetratricopeptide repeat
SPYM3_RS03600	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYM3_RS03615	COG1129	ABC transporter
SPYM3_RS03635	COG0488	(ABC) transporter
SPYM3_RS03640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYM3_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYM3_RS03645	COG0022	dehydrogenase e1 component
SPYM3_RS03650	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYM3_RS03665	COG5492	domain, Protein
SPYM3_RS03670	COG0095	Lipoate-protein ligase
SPYM3_RS03675	COG3442	glutamine amidotransferase
SPYM3_RS03680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYM3_RS03685	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYM3_RS03705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYM3_RS03715	COG0647	UMP catabolic process
SPYM3_RS03730	COG1518	maintenance of DNA repeat elements
SPYM3_RS03735	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPYM3_RS03800	COG0305	Participates in initiation and elongation during chromosome replication
SPYM3_RS03810	COG1484	DNA-dependent DNA replication
SPYM3_RS03870	COG0582	viral genome integration into host DNA
SPYM3_RS03915	COG0740	serine-type endopeptidase activity
SPYM3_RS04010	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM3_RS04040	COG0105	UTP biosynthetic process
SPYM3_RS04075	COG3715	PTS system
SPYM3_RS04080	COG3716	PTS system mannose fructose sorbose family IID component
SPYM3_RS04085	COG2972	Histidine kinase
SPYM3_RS04090	COG2207	Transcriptional regulator
SPYM3_RS04090	COG4753	response regulator
SPYM3_RS04100	COG1012	belongs to the aldehyde dehydrogenase family
SPYM3_RS04115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYM3_RS04145	COG0285	dihydrofolate synthase activity
SPYM3_RS04180	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYM3_RS04185	COG1177	transmembrane transport
SPYM3_RS04195	COG4565	transcriptional regulatory protein
SPYM3_RS04200	COG3290	protein histidine kinase activity
SPYM3_RS04205	COG3493	citrate carrier protein
SPYM3_RS04220	COG3700	Belongs to the class B bacterial acid phosphatase family
SPYM3_RS04225	COG0038	chloride channel
SPYM3_RS04235	COG0628	permease
SPYM3_RS04245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYM3_RS04260	COG1104	cysteine desulfurase activity
SPYM3_RS04275	COG2357	RelA SpoT domain protein
SPYM3_RS04285	COG0564	pseudouridine synthase activity
SPYM3_RS04290	COG0280	phosphate acetyltransferase
SPYM3_RS04310	COG1174	glycine betaine transport
SPYM3_RS04325	COG2233	PERMEase
SPYM3_RS04350	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYM3_RS04385	COG1132	(ABC) transporter
SPYM3_RS04405	COG3764	Sortase (surface protein transpeptidase)
SPYM3_RS04410	COG0346	lactoylglutathione lyase activity
SPYM3_RS04425	COG1272	protein, Hemolysin III
SPYM3_RS04445	COG0758	DNA mediated transformation
SPYM3_RS04450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYM3_RS04470	COG0511	ligase activity, forming carbon-carbon bonds
SPYM3_RS04475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYM3_RS04490	COG2851	Citrate transporter
SPYM3_RS04500	COG0511	ligase activity, forming carbon-carbon bonds
SPYM3_RS04505	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYM3_RS04540	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYM3_RS04560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYM3_RS04570	COG2188	Transcriptional regulator
SPYM3_RS04590	COG0488	(ABC) transporter
SPYM3_RS04600	COG0352	thiamine-phosphate diphosphorylase activity
SPYM3_RS04600	COG0351	phosphomethylpyrimidine kinase
SPYM3_RS04605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYM3_RS04610	COG1328	CTP reductase activity
SPYM3_RS04610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYM3_RS04615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYM3_RS04645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYM3_RS04665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYM3_RS04670	COG4684	Psort location CytoplasmicMembrane, score
SPYM3_RS04675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYM3_RS04680	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYM3_RS04685	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYM3_RS04690	COG3845	ABC transporter
SPYM3_RS04695	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYM3_RS04700	COG0295	cytidine deaminase activity
SPYM3_RS04705	COG2813	Specifically methylates the guanine in position
SPYM3_RS04720	COG5002	protein histidine kinase activity
SPYM3_RS04725	COG0745	RESPONSE REGULATOR receiver
SPYM3_RS04735	COG0704	Plays a role in the regulation of phosphate uptake
SPYM3_RS04750	COG0581	inorganic phosphate transmembrane transporter activity
SPYM3_RS04755	COG0573	inorganic phosphate transmembrane transporter activity
SPYM3_RS04765	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYM3_RS04765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYM3_RS04770	COG0483	inositol monophosphate 1-phosphatase activity
SPYM3_RS04785	COG0196	riboflavin kinase activity
SPYM3_RS04815	COG1136	(ABC) transporter
SPYM3_RS04815	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYM3_RS04865	COG1115	amino acid carrier protein
SPYM3_RS04870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYM3_RS04880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM3_RS04885	COG1126	abc transporter atp-binding protein
SPYM3_RS04890	COG0765	amino acid transport
SPYM3_RS04895	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYM3_RS04910	COG0469	pyruvate kinase activity
SPYM3_RS04925	COG1725	Transcriptional regulator
SPYM3_RS04930	COG1131	(ABC) transporter
SPYM3_RS04955	COG3177	Filamentation induced by cAMP protein fic
SPYM3_RS04960	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYM3_RS04960	COG1388	LysM domain
SPYM3_RS05055	COG0740	serine-type endopeptidase activity
SPYM3_RS05235	COG0058	SHG alpha-glucan phosphorylase activity
SPYM3_RS05240	COG1640	4-alpha-glucanotransferase
SPYM3_RS05245	COG1609	Transcriptional regulator
SPYM3_RS05250	COG2182	Extracellular solute-binding protein
SPYM3_RS05255	COG1175	transmembrane transport
SPYM3_RS05260	COG3833	ABC-type maltose transport systems, permease component
SPYM3_RS05275	COG0657	acetylesterase activity
SPYM3_RS05280	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYM3_RS05290	COG1696	Membrane protein involved in D-alanine export
SPYM3_RS05310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM3_RS05315	COG1126	abc transporter atp-binding protein
SPYM3_RS05320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM3_RS05330	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM3_RS05340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYM3_RS05340	COG3711	transcriptional antiterminator
SPYM3_RS05350	COG2723	6-phospho-beta-galactosidase activity
SPYM3_RS05375	COG2801	Transposase and inactivated derivatives
SPYM3_RS05380	COG0157	Belongs to the NadC ModD family
SPYM3_RS05395	COG2801	Transposase and inactivated derivatives
SPYM3_RS05405	COG1187	pseudouridine synthase activity
SPYM3_RS05415	COG2814	Major facilitator Superfamily
SPYM3_RS05465	COG4109	DRTGG domain
SPYM3_RS05495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYM3_RS05495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYM3_RS05500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYM3_RS05505	COG1956	GAF domain-containing protein
SPYM3_RS05525	COG0513	Belongs to the DEAD box helicase family
SPYM3_RS05530	COG0726	polysaccharide deacetylase
SPYM3_RS05550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYM3_RS05555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYM3_RS05560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYM3_RS05575	COG2801	Transposase and inactivated derivatives
SPYM3_RS05580	COG2801	Transposase and inactivated derivatives
SPYM3_RS05595	COG1476	TRANSCRIPTIONal
SPYM3_RS05610	COG4122	O-methyltransferase activity
SPYM3_RS05615	COG2223	nitrite transmembrane transporter activity
SPYM3_RS05630	COG1187	pseudouridine synthase activity
SPYM3_RS05675	COG0658	competence protein
SPYM3_RS05675	COG2333	competence protein COMEC
SPYM3_RS05680	COG1596	polysaccharide export
SPYM3_RS05680	COG1555	photosystem II stabilization
SPYM3_RS05685	COG0204	Acyl-transferase
SPYM3_RS05690	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYM3_RS05705	COG0513	Belongs to the DEAD box helicase family
SPYM3_RS05720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYM3_RS05735	COG0768	penicillin binding
SPYM3_RS05740	COG2116	formate transmembrane transporter activity
SPYM3_RS05750	COG1827	regulation of RNA biosynthetic process
SPYM3_RS05765	COG2217	Heavy metal translocating P-type atpase
SPYM3_RS05790	COG4824	toxin secretion phage lysis holin
SPYM3_RS05965	COG3723	Recombinational DNA repair protein, rece pathway
SPYM3_RS06010	COG1396	sequence-specific DNA binding
SPYM3_RS06020	COG0582	viral genome integration into host DNA
SPYM3_RS06035	COG2755	lipolytic protein G-D-S-L family
SPYM3_RS06050	COG0497	DNA recombination
SPYM3_RS06055	COG1438	arginine binding
SPYM3_RS06060	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYM3_RS06085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYM3_RS06090	COG0415	Belongs to the DNA photolyase family
SPYM3_RS06100	COG0765	amino acid transport
SPYM3_RS06105	COG4703	Protein of unknown function (DUF1797)
SPYM3_RS06110	COG0542	response to heat
SPYM3_RS06115	COG0494	nUDIX hydrolase
SPYM3_RS06130	COG3599	regulation of cell shape
SPYM3_RS06135	COG2302	S4 RNA-binding domain
SPYM3_RS06150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYM3_RS06175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPYM3_RS06185	COG1217	gtp-binding protein TYPA
SPYM3_RS06190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYM3_RS06195	COG1940	carbohydrate kinase activity
SPYM3_RS06205	COG0783	Belongs to the Dps family
SPYM3_RS06220	COG4470	Protein conserved in bacteria
SPYM3_RS06225	COG1609	Transcriptional regulator
SPYM3_RS06230	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYM3_RS06240	COG0742	ribosomal rna small subunit methyltransferase
SPYM3_RS06250	COG0549	Belongs to the carbamate kinase family
SPYM3_RS06255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYM3_RS06260	COG1288	antiporter activity
SPYM3_RS06300	COG2972	Histidine kinase
SPYM3_RS06340	COG1388	LysM domain
SPYM3_RS06340	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYM3_RS06485	COG1475	DNA binding
SPYM3_RS06560	COG3935	DnaD domain protein
SPYM3_RS06590	COG3561	AntA/AntB antirepressor
SPYM3_RS06600	COG1396	sequence-specific DNA binding
SPYM3_RS06625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYM3_RS06630	COG0785	Cytochrome C biogenesis protein
SPYM3_RS06640	COG0673	inositol 2-dehydrogenase activity
SPYM3_RS06680	COG1605	Chorismate mutase
SPYM3_RS06680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYM3_RS06700	COG2226	methyltransferase
SPYM3_RS06710	COG3250	beta-galactosidase activity
SPYM3_RS06715	COG4753	response regulator
SPYM3_RS06715	COG2207	Transcriptional regulator
SPYM3_RS06720	COG2972	Histidine kinase
SPYM3_RS06730	COG1653	transport
SPYM3_RS06735	COG0395	ABC-type sugar transport system, permease component
SPYM3_RS06740	COG1175	transmembrane transport
SPYM3_RS06745	COG1940	carbohydrate kinase activity
SPYM3_RS06750	COG2723	6-phospho-beta-galactosidase activity
SPYM3_RS06755	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYM3_RS06760	COG1609	Transcriptional regulator
SPYM3_RS06770	COG0383	alpha-mannosidase activity
SPYM3_RS07135	COG1739	Uncharacterized protein family UPF0029
SPYM3_RS07145	COG1098	S1 RNA binding domain
SPYM3_RS07155	COG2197	response regulator
SPYM3_RS07160	COG4585	Histidine kinase
SPYM3_RS07170	COG2815	serine threonine protein kinase
SPYM3_RS07170	COG0515	serine threonine protein kinase
SPYM3_RS07180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYM3_RS07180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYM3_RS07190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYM3_RS07210	COG0583	DNA-binding transcription factor activity
SPYM3_RS07215	COG0183	Belongs to the thiolase family
SPYM3_RS07220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYM3_RS07235	COG2610	gluconate transmembrane transporter activity
SPYM3_RS07250	COG0116	Belongs to the methyltransferase superfamily
SPYM3_RS07270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM3_RS07275	COG3579	cysteine-type endopeptidase activity
SPYM3_RS07285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYM3_RS07290	COG1113	amino acid transport
SPYM3_RS07295	COG0492	ferredoxin-NADP+ reductase activity
SPYM3_RS07305	COG1126	abc transporter atp-binding protein
SPYM3_RS07315	COG0513	Belongs to the DEAD box helicase family
SPYM3_RS07325	COG0768	penicillin binding
SPYM3_RS07490	COG1783	phage Terminase large subunit
SPYM3_RS07600	COG1131	(ABC) transporter
SPYM3_RS07625	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYM3_RS07630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM3_RS07665	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYM3_RS07670	COG0656	L-ascorbic acid biosynthetic process
SPYM3_RS07680	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYM3_RS07700	COG0561	phosphatase activity
SPYM3_RS07705	COG2860	membrane
SPYM3_RS07715	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYM3_RS07755	COG2217	Heavy metal translocating P-type atpase
SPYM3_RS07785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYM3_RS07790	COG0195	Participates in both transcription termination and antitermination
SPYM3_RS07815	COG4473	ABC transporter
SPYM3_RS07820	COG1131	(ABC) transporter
SPYM3_RS07825	COG0537	adenosine 5'-monophosphoramidase activity
SPYM3_RS07835	COG1316	TRANSCRIPTIONal
SPYM3_RS07845	COG0802	atpase or kinase
SPYM3_RS07850	COG2252	PERMEase
SPYM3_RS07855	COG0561	phosphatase activity
SPYM3_RS07865	COG3715	PTS system
SPYM3_RS07870	COG3716	PTS system mannose fructose sorbose family IID component
SPYM3_RS07880	COG5433	transposase activity
SPYM3_RS07905	COG0439	Biotin carboxylase
SPYM3_RS07920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYM3_RS07925	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM3_RS07930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYM3_RS07955	COG1024	Enoyl-CoA hydratase
SPYM3_RS07990	COG0588	phosphoglycerate mutase activity
SPYM3_RS07995	COG2261	transglycosylase associated protein
SPYM3_RS08025	COG1335	isochorismatase
SPYM3_RS08035	COG0436	Aminotransferase
SPYM3_RS08045	COG0561	phosphatase activity
SPYM3_RS08050	COG0252	asparaginase activity
SPYM3_RS08065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYM3_RS08070	COG1129	ABC transporter
SPYM3_RS08085	COG1132	(ABC) transporter
SPYM3_RS08090	COG4988	ABC transporter
SPYM3_RS08095	COG1120	ATPase activity
SPYM3_RS08120	COG1388	LysM domain
SPYM3_RS08120	COG3942	CHAP domain
SPYM3_RS08140	COG1482	cell wall glycoprotein biosynthetic process
SPYM3_RS08145	COG1940	carbohydrate kinase activity
SPYM3_RS08155	COG2190	(PTS) system
SPYM3_RS08155	COG1263	PTS System
SPYM3_RS08155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM3_RS08160	COG1621	beta-fructofuranosidase activity
SPYM3_RS08165	COG1609	Transcriptional regulator
SPYM3_RS08185	COG2131	deaminase
SPYM3_RS08190	COG0006	proline dipeptidase activity
SPYM3_RS08230	COG1194	a g-specific adenine glycosylase
SPYM3_RS08235	COG3620	sequence-specific DNA binding
SPYM3_RS08240	COG3118	belongs to the thioredoxin family
SPYM3_RS08270	COG0681	Belongs to the peptidase S26 family
SPYM3_RS08275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYM3_RS08290	COG1882	Formate acetyltransferase
SPYM3_RS08295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYM3_RS08310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM3_RS08315	COG2814	Major facilitator Superfamily
SPYM3_RS08320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYM3_RS08345	COG0789	Transcriptional regulator
SPYM3_RS08360	COG2081	HI0933 family
SPYM3_RS08370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYM3_RS08375	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYM3_RS08395	COG0456	acetyltransferase
SPYM3_RS08400	COG1214	PFAM Peptidase M22, glycoprotease
SPYM3_RS08415	COG0174	glutamine synthetase
SPYM3_RS08420	COG0789	Transcriptional regulator
SPYM3_RS08435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYM3_RS08490	COG0668	transmembrane transport
SPYM3_RS08500	COG4720	Psort location CytoplasmicMembrane, score
SPYM3_RS08505	COG0351	phosphomethylpyrimidine kinase
SPYM3_RS08550	COG1929	Belongs to the glycerate kinase type-1 family
SPYM3_RS08555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYM3_RS08580	COG0577	efflux transmembrane transporter activity
SPYM3_RS08585	COG1136	(ABC) transporter
SPYM3_RS08615	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM3_RS08615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM3_RS08620	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM3_RS08670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYM3_RS08675	COG1476	TRANSCRIPTIONal
SPYM3_RS08705	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYM3_RS08720	COG1045	serine acetyltransferase
SPYM3_RS08735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYM3_RS08750	COG3711	transcriptional antiterminator
SPYM3_RS08775	COG0431	NADPH-dependent FMN reductase
SPYM3_RS08780	COG1846	Transcriptional regulator
SPYM3_RS08800	COG4589	Belongs to the CDS family
SPYM3_RS08810	COG1862	Preprotein translocase
SPYM3_RS08820	COG1523	belongs to the glycosyl hydrolase 13 family
SPYM3_RS08830	COG3842	ATPase activity
SPYM3_RS08865	COG5433	transposase activity
SPYM3_RS08880	COG1263	PTS System
SPYM3_RS08880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM3_RS08880	COG2190	(PTS) system
SPYM3_RS08885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYM3_RS08900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYM3_RS08905	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYM3_RS08910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYM3_RS08935	COG0601	transmembrane transport
SPYM3_RS08965	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYM3_RS08975	COG1196	nuclear chromosome segregation
SPYM3_RS08980	COG3711	transcriptional antiterminator
SPYM3_RS08990	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM3_RS08990	COG3942	CHAP domain
SPYM3_RS08995	COG2205	protein histidine kinase activity
SPYM3_RS09000	COG0745	RESPONSE REGULATOR receiver
SPYM3_RS09005	COG0577	efflux transmembrane transporter activity
SPYM3_RS09010	COG1136	(ABC) transporter
SPYM3_RS09060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYM3_RS09075	COG1882	Formate acetyltransferase
SPYM3_RS09080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM3_RS09085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM3_RS09090	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM3_RS09095	COG2390	Transcriptional regulator
SPYM3_RS09100	COG1349	DNA-binding transcription factor activity
SPYM3_RS09105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYM3_RS09120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM3_RS09135	COG0564	pseudouridine synthase activity
SPYM3_RS09170	COG0542	response to heat
SPYM3_RS09175	COG4463	regulation of RNA biosynthetic process
SPYM3_RS09190	COG0450	alkyl hydroperoxide reductase
SPYM3_RS09205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYM3_RS09215	COG3404	Formiminotransferase-cyclodeaminase
SPYM3_RS09230	COG0531	amino acid
SPYM3_RS09260	COG3590	peptidase
SPYM3_RS09265	COG0366	Alpha amylase catalytic
SPYM3_RS09270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM3_RS09270	COG1263	PTS System
SPYM3_RS09275	COG2188	Transcriptional regulator
SPYM3_RS09285	COG2514	catechol 2,3-dioxygenase activity
SPYM3_RS09295	COG0602	queuosine metabolic process
SPYM3_RS09310	COG1328	CTP reductase activity
SPYM3_RS09335	COG1393	Belongs to the ArsC family
SPYM3_RS09350	COG0519	Catalyzes the synthesis of GMP from XMP
SPYM3_RS09395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM3_RS09400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM3_RS09405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM3_RS09485	COG1511	domain protein
SPYM3_RS09505	COG0305	Participates in initiation and elongation during chromosome replication
SPYM3_RS09535	COG1760	l-serine dehydratase
SPYM3_RS09540	COG1760	l-serine dehydratase
SPYM3_RS09545	COG0741	lytic transglycosylase activity
SPYM3_RS09550	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYM3_RS09565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYM3_RS09575	COG0612	Peptidase, M16
SPYM3_RS09625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM3_RS09630	COG0488	(ABC) transporter
SPYM3_RS09665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYM3_RS09670	COG1475	DNA binding