locus-tag	class	description
M28_RS00010	COG0592	DNA-directed DNA polymerase activity
M28_RS00020	COG0012	GTP binding
M28_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M28_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M28_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M28_RS00065	COG0531	amino acid
M28_RS00245	COG3942	CHAP domain
M28_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M28_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M28_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M28_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M28_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M28_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M28_RS00355	COG1454	alcohol dehydrogenase
M28_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
M28_RS00360	COG1064	alcohol dehydrogenase
M28_RS00365	COG0534	Mate efflux family protein
M28_RS00475	COG0201	protein transport
M28_RS00620	COG1121	(ABC) transporter
M28_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M28_RS00640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M28_RS00660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M28_RS00665	COG1459	type II secretion system
M28_RS00670	COG4537	Required for transformation and DNA binding
M28_RS00710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M28_RS00715	COG1363	Peptidase, m42
M28_RS00730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M28_RS00735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M28_RS00745	COG1428	Deoxynucleoside kinase
M28_RS00750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M28_RS00795	COG4509	Sortase family
M28_RS00820	COG2031	fatty acid transporter
M28_RS00835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M28_RS00850	COG0251	oxidation-reduction process
M28_RS00865	COG1269	ATP hydrolysis coupled proton transport
M28_RS00870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M28_RS00880	COG1527	subunit (C
M28_RS00885	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M28_RS00920	COG1744	ABC transporter substrate-binding protein PnrA-like
M28_RS00965	COG0626	cystathionine gamma-synthase activity
M28_RS00995	COG3623	hexulose-6-phosphate isomerase
M28_RS01020	COG4175	Glycine betaine
M28_RS01020	COG3448	diguanylate cyclase activity
M28_RS01030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M28_RS01030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M28_RS01050	COG3969	phosphoadenosine phosphosulfate
M28_RS01055	COG1475	DNA binding
M28_RS01105	COG1268	BioY protein
M28_RS01110	COG1234	tRNA 3'-trailer cleavage
M28_RS01145	COG0457	Tetratricopeptide repeat
M28_RS01145	COG0705	Rhomboid family
M28_RS01165	COG1132	(ABC) transporter
M28_RS01170	COG1132	(ABC) transporter
M28_RS01180	COG0756	dUTP diphosphatase activity
M28_RS01205	COG3290	protein histidine kinase activity
M28_RS01230	COG1847	R3H domain protein
M28_RS01250	COG1175	transmembrane transport
M28_RS01255	COG0395	ABC-type sugar transport system, permease component
M28_RS01265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M28_RS01280	COG0084	hydrolase, TatD family'
M28_RS01305	COG1564	THIamine pyrophosphokinase
M28_RS01320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M28_RS01360	COG0765	amino acid transport
M28_RS01380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M28_RS01390	COG0719	Fe-S assembly protein
M28_RS01395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M28_RS01410	COG1686	Belongs to the peptidase S11 family
M28_RS01415	COG1686	Belongs to the peptidase S11 family
M28_RS01420	COG4166	transmembrane transport
M28_RS01425	COG0601	transmembrane transport
M28_RS01430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M28_RS01435	COG0444	Belongs to the ABC transporter superfamily
M28_RS01485	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M28_RS01490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M28_RS01495	COG1534	Rna-binding protein
M28_RS01505	COG1713	HD superfamily hydrolase involved in NAD metabolism
M28_RS01510	COG0799	negative regulation of ribosome biogenesis
M28_RS01515	COG2226	methyltransferase
M28_RS01535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M28_RS01540	COG1464	Belongs to the NlpA lipoprotein family
M28_RS01555	COG1114	Component of the transport system for branched-chain amino acids
M28_RS01565	COG0569	domain protein
M28_RS01570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M28_RS01580	COG1704	LemA family
M28_RS01595	COG0745	RESPONSE REGULATOR receiver
M28_RS01615	COG1484	DNA-dependent DNA replication
M28_RS01625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M28_RS01645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M28_RS01660	COG1254	Belongs to the acylphosphatase family
M28_RS01665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M28_RS01720	COG1187	pseudouridine synthase activity
M28_RS01735	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M28_RS01740	COG0671	phosphoesterase, PA-phosphatase related
M28_RS01745	COG1242	4 iron, 4 sulfur cluster binding
M28_RS01750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M28_RS01755	COG1253	flavin adenine dinucleotide binding
M28_RS01760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M28_RS01775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M28_RS01780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M28_RS01785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M28_RS01790	COG1120	ATPase activity
M28_RS01800	COG2244	polysaccharide biosynthetic process
M28_RS01830	COG0470	DNA polymerase III
M28_RS01855	COG1393	Belongs to the ArsC family
M28_RS01860	COG0708	Exodeoxyribonuclease III
M28_RS01870	COG1304	FMN binding
M28_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
M28_RS01975	COG0673	inositol 2-dehydrogenase activity
M28_RS01990	COG0494	nUDIX hydrolase
M28_RS02000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M28_RS02090	COG1702	phosphate starvation-inducible protein PhoH
M28_RS02095	COG1573	uracil-dna glycosylase
M28_RS02105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M28_RS02210	COG0433	COG0433 Predicted ATPase
M28_RS02215	COG2814	Major facilitator Superfamily
M28_RS02230	COG0557	exoribonuclease II activity
M28_RS02260	COG0463	Glycosyl transferase, family 2
M28_RS02270	COG0778	Nitroreductase
M28_RS02275	COG0006	proline dipeptidase activity
M28_RS02280	COG1609	Transcriptional regulator
M28_RS02290	COG0438	transferase activity, transferring glycosyl groups
M28_RS02300	COG4555	ABC transporter
M28_RS02320	COG0183	Belongs to the thiolase family
M28_RS02335	COG0745	RESPONSE REGULATOR receiver
M28_RS02340	COG5002	protein histidine kinase activity
M28_RS02345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M28_RS02355	COG1196	nuclear chromosome segregation
M28_RS02370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M28_RS02465	COG0561	phosphatase activity
M28_RS02470	COG0561	phosphatase activity
M28_RS02475	COG0552	protein localization to endoplasmic reticulum
M28_RS02480	COG0477	Major facilitator Superfamily
M28_RS02485	COG3711	transcriptional antiterminator
M28_RS02490	COG2190	(PTS) system
M28_RS02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M28_RS02490	COG1263	PTS System
M28_RS02500	COG3689	TIGRFAM TIGR03943 family protein
M28_RS02505	COG0701	Predicted permease
M28_RS02515	COG2183	response to ionizing radiation
M28_RS02560	COG0826	peptidase U32
M28_RS02565	COG4443	Transcriptional Coactivator p15 (PC4)
M28_RS02615	COG1164	Oligoendopeptidase f
M28_RS02625	COG0772	Belongs to the SEDS family
M28_RS02660	COG1078	dGTPase activity
M28_RS02675	COG1609	Transcriptional regulator
M28_RS02685	COG3716	PTS system mannose fructose sorbose family IID component
M28_RS02690	COG3715	PTS system
M28_RS02695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M28_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
M28_RS02725	COG0800	Aldolase
M28_RS02730	COG0546	phosphoglycolate phosphatase activity
M28_RS02740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M28_RS02750	COG2884	Cell division ATP-binding protein ftsE
M28_RS02755	COG2177	Part of the ABC transporter FtsEX involved in
M28_RS02770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M28_RS02770	COG1199	ATP-dependent helicase activity
M28_RS02775	COG0436	Aminotransferase
M28_RS02810	COG2188	Transcriptional regulator
M28_RS02815	COG2222	sugar isomerase
M28_RS02825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M28_RS02830	COG0716	FMN binding
M28_RS02840	COG0038	chloride channel
M28_RS02935	COG1131	(ABC) transporter
M28_RS02960	COG4708	membrane
M28_RS02970	COG1597	lipid kinase activity
M28_RS03055	COG0577	efflux transmembrane transporter activity
M28_RS03065	COG2321	neutral zinc metallopeptidase
M28_RS03080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M28_RS03090	COG1970	mechanosensitive ion channel activity
M28_RS03095	COG0358	DNA primase activity
M28_RS03100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M28_RS03105	COG2151	metal-sulfur cluster biosynthetic enzyme
M28_RS03150	COG1216	Glycosyl transferase, family 2
M28_RS03210	COG1368	sulfuric ester hydrolase activity
M28_RS03215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M28_RS03235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M28_RS03240	COG0285	dihydrofolate synthase activity
M28_RS03250	COG1104	cysteine desulfurase activity
M28_RS03275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M28_RS03285	COG0583	DNA-binding transcription factor activity
M28_RS03295	COG0564	pseudouridine synthase activity
M28_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M28_RS03335	COG1136	(ABC) transporter
M28_RS03340	COG0577	efflux transmembrane transporter activity
M28_RS03345	COG0584	glycerophosphoryl diester phosphodiesterase
M28_RS03355	COG1837	Belongs to the UPF0109 family
M28_RS03405	COG1349	DNA-binding transcription factor activity
M28_RS03410	COG1105	Belongs to the carbohydrate kinase PfkB family
M28_RS03415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M28_RS03415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M28_RS03415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M28_RS03420	COG1705	Flagellar rod assembly protein muramidase FlgJ
M28_RS03420	COG1388	LysM domain
M28_RS03425	COG1705	Flagellar rod assembly protein muramidase FlgJ
M28_RS03425	COG1388	LysM domain
M28_RS03445	COG0105	UTP biosynthetic process
M28_RS03465	COG0488	(ABC) transporter
M28_RS03475	COG0242	peptide deformylase activity
M28_RS03480	COG0737	Belongs to the 5'-nucleotidase family
M28_RS03485	COG2357	RelA SpoT domain protein
M28_RS03490	COG0745	RESPONSE REGULATOR receiver
M28_RS03525	COG3425	synthase
M28_RS03535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M28_RS03580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M28_RS03595	COG0583	DNA-binding transcription factor activity
M28_RS03620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M28_RS03625	COG0765	amino acid transport
M28_RS03645	COG0187	DNA topoisomerase II activity
M28_RS03655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M28_RS03675	COG0539	negative regulation of cytoplasmic translation
M28_RS03720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M28_RS03725	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M28_RS03735	COG0300	oxidoreductase activity
M28_RS03740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M28_RS03740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M28_RS03755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M28_RS03760	COG2384	SAM-dependent methyltransferase
M28_RS03770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M28_RS03775	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M28_RS03785	COG1088	dTDP-glucose 4,6-dehydratase activity
M28_RS03790	COG1051	belongs to the nudix hydrolase family
M28_RS03795	COG0628	permease
M28_RS03800	COG0457	Tetratricopeptide repeat
M28_RS03805	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M28_RS03825	COG1129	ABC transporter
M28_RS03845	COG0488	(ABC) transporter
M28_RS03850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M28_RS03855	COG0022	dehydrogenase e1 component
M28_RS03855	COG0508	dehydrogenase complex catalyzes the overall conversion of
M28_RS03860	COG0508	dehydrogenase complex catalyzes the overall conversion of
M28_RS03880	COG5492	domain, Protein
M28_RS03885	COG0095	Lipoate-protein ligase
M28_RS03890	COG3442	glutamine amidotransferase
M28_RS03895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M28_RS03900	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M28_RS03920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M28_RS03930	COG0647	UMP catabolic process
M28_RS03945	COG1518	maintenance of DNA repeat elements
M28_RS03950	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M28_RS03960	COG5433	transposase activity
M28_RS04000	COG3715	PTS system
M28_RS04005	COG3716	PTS system mannose fructose sorbose family IID component
M28_RS04010	COG2972	Histidine kinase
M28_RS04015	COG2207	Transcriptional regulator
M28_RS04015	COG4753	response regulator
M28_RS04025	COG1012	belongs to the aldehyde dehydrogenase family
M28_RS04040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M28_RS04115	COG1131	(ABC) transporter
M28_RS04130	COG1396	sequence-specific DNA binding
M28_RS04160	COG0285	dihydrofolate synthase activity
M28_RS04180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M28_RS04195	COG1176	ABC-type spermidine putrescine transport system, permease component I
M28_RS04200	COG1177	transmembrane transport
M28_RS04210	COG4565	transcriptional regulatory protein
M28_RS04215	COG3290	protein histidine kinase activity
M28_RS04220	COG3493	citrate carrier protein
M28_RS04230	COG1063	alcohol dehydrogenase
M28_RS04235	COG3700	Belongs to the class B bacterial acid phosphatase family
M28_RS04240	COG0038	chloride channel
M28_RS04250	COG0628	permease
M28_RS04260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M28_RS04275	COG1104	cysteine desulfurase activity
M28_RS04290	COG2357	RelA SpoT domain protein
M28_RS04300	COG0564	pseudouridine synthase activity
M28_RS04305	COG0280	phosphate acetyltransferase
M28_RS04310	COG4221	oxidoreductase activity
M28_RS04325	COG1174	glycine betaine transport
M28_RS04345	COG2233	PERMEase
M28_RS04370	COG2890	protein-(glutamine-N5) methyltransferase activity
M28_RS04400	COG1132	(ABC) transporter
M28_RS04405	COG1132	(ABC) transporter
M28_RS04425	COG3764	Sortase (surface protein transpeptidase)
M28_RS04430	COG0346	lactoylglutathione lyase activity
M28_RS04445	COG1597	lipid kinase activity
M28_RS04450	COG1272	protein, Hemolysin III
M28_RS04470	COG0758	DNA mediated transformation
M28_RS04475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M28_RS04525	COG0511	ligase activity, forming carbon-carbon bonds
M28_RS04530	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M28_RS04545	COG2851	Citrate transporter
M28_RS04555	COG0511	ligase activity, forming carbon-carbon bonds
M28_RS04560	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M28_RS04590	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
M28_RS04610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M28_RS04620	COG2188	Transcriptional regulator
M28_RS04640	COG0488	(ABC) transporter
M28_RS04650	COG0352	thiamine-phosphate diphosphorylase activity
M28_RS04650	COG0351	phosphomethylpyrimidine kinase
M28_RS04655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M28_RS04660	COG1328	CTP reductase activity
M28_RS04660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M28_RS04665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M28_RS04695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M28_RS04715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M28_RS04720	COG4684	Psort location CytoplasmicMembrane, score
M28_RS04725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M28_RS04730	COG1079	Belongs to the binding-protein-dependent transport system permease family
M28_RS04735	COG4603	Belongs to the binding-protein-dependent transport system permease family
M28_RS04740	COG3845	ABC transporter
M28_RS04745	COG1744	ABC transporter substrate-binding protein PnrA-like
M28_RS04750	COG0295	cytidine deaminase activity
M28_RS04755	COG2813	Specifically methylates the guanine in position
M28_RS04770	COG5002	protein histidine kinase activity
M28_RS04775	COG0745	RESPONSE REGULATOR receiver
M28_RS04790	COG0704	Plays a role in the regulation of phosphate uptake
M28_RS04805	COG0581	inorganic phosphate transmembrane transporter activity
M28_RS04810	COG0573	inorganic phosphate transmembrane transporter activity
M28_RS04820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M28_RS04820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M28_RS04825	COG0483	inositol monophosphate 1-phosphatase activity
M28_RS04840	COG0196	riboflavin kinase activity
M28_RS04870	COG1136	(ABC) transporter
M28_RS04870	COG4591	ABC-type transport system involved in lipoprotein release permease component
M28_RS04920	COG1115	amino acid carrier protein
M28_RS04925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M28_RS04935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M28_RS04940	COG1126	abc transporter atp-binding protein
M28_RS04945	COG0765	amino acid transport
M28_RS04950	COG2824	Alkylphosphonate utilization operon protein PhnA
M28_RS04965	COG0469	pyruvate kinase activity
M28_RS04980	COG1725	Transcriptional regulator
M28_RS04985	COG1131	(ABC) transporter
M28_RS05170	COG1598	PFAM Uncharacterised protein family UPF0150
M28_RS05355	COG0058	SHG alpha-glucan phosphorylase activity
M28_RS05360	COG1640	4-alpha-glucanotransferase
M28_RS05365	COG1609	Transcriptional regulator
M28_RS05370	COG2182	Extracellular solute-binding protein
M28_RS05375	COG1175	transmembrane transport
M28_RS05380	COG3833	ABC-type maltose transport systems, permease component
M28_RS05395	COG3833	ABC-type maltose transport systems, permease component
M28_RS05400	COG1175	transmembrane transport
M28_RS05410	COG0366	Alpha amylase catalytic
M28_RS05415	COG2182	Extracellular solute-binding protein
M28_RS05425	COG0657	acetylesterase activity
M28_RS05430	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M28_RS05440	COG1696	Membrane protein involved in D-alanine export
M28_RS05460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M28_RS05465	COG1126	abc transporter atp-binding protein
M28_RS05470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M28_RS05480	COG1447	Phosphotransferase system cellobiose-specific component IIA
M28_RS05490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M28_RS05490	COG3711	transcriptional antiterminator
M28_RS05500	COG2723	6-phospho-beta-galactosidase activity
M28_RS05530	COG1187	pseudouridine synthase activity
M28_RS05540	COG2814	Major facilitator Superfamily
M28_RS05660	COG4109	DRTGG domain
M28_RS05665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M28_RS05690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M28_RS05690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M28_RS05700	COG5433	transposase activity
M28_RS05705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M28_RS05710	COG1956	GAF domain-containing protein
M28_RS05730	COG0513	Belongs to the DEAD box helicase family
M28_RS05735	COG0726	polysaccharide deacetylase
M28_RS05755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M28_RS05760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M28_RS05790	COG1476	TRANSCRIPTIONal
M28_RS05805	COG4122	O-methyltransferase activity
M28_RS05810	COG2223	nitrite transmembrane transporter activity
M28_RS05825	COG1187	pseudouridine synthase activity
M28_RS05875	COG1555	photosystem II stabilization
M28_RS05875	COG1596	polysaccharide export
M28_RS05880	COG0204	Acyl-transferase
M28_RS05885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M28_RS05900	COG0513	Belongs to the DEAD box helicase family
M28_RS05920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M28_RS05935	COG0768	penicillin binding
M28_RS05940	COG2116	formate transmembrane transporter activity
M28_RS05950	COG1827	regulation of RNA biosynthetic process
M28_RS05965	COG2217	Heavy metal translocating P-type atpase
M28_RS05980	COG2755	lipolytic protein G-D-S-L family
M28_RS05995	COG0497	DNA recombination
M28_RS06000	COG1438	arginine binding
M28_RS06005	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M28_RS06030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M28_RS06035	COG0415	Belongs to the DNA photolyase family
M28_RS06045	COG0765	amino acid transport
M28_RS06050	COG4703	Protein of unknown function (DUF1797)
M28_RS06055	COG0542	response to heat
M28_RS06060	COG0494	nUDIX hydrolase
M28_RS06075	COG3599	regulation of cell shape
M28_RS06080	COG2302	S4 RNA-binding domain
M28_RS06095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M28_RS06130	COG1217	gtp-binding protein TYPA
M28_RS06135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M28_RS06140	COG1940	carbohydrate kinase activity
M28_RS06150	COG0783	Belongs to the Dps family
M28_RS06165	COG4470	Protein conserved in bacteria
M28_RS06170	COG1609	Transcriptional regulator
M28_RS06175	COG3480	Lon protease (S16) C-terminal proteolytic domain
M28_RS06185	COG0742	ribosomal rna small subunit methyltransferase
M28_RS06195	COG0549	Belongs to the carbamate kinase family
M28_RS06200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M28_RS06205	COG1288	antiporter activity
M28_RS06220	COG2235	arginine
M28_RS06245	COG2972	Histidine kinase
M28_RS06285	COG0860	N-Acetylmuramoyl-L-alanine amidase
M28_RS06285	COG1388	LysM domain
M28_RS06430	COG1475	DNA binding
M28_RS06530	COG3935	DnaD domain protein
M28_RS06565	COG3561	AntA/AntB antirepressor
M28_RS06575	COG1396	sequence-specific DNA binding
M28_RS06600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M28_RS06605	COG0785	Cytochrome C biogenesis protein
M28_RS06610	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M28_RS06615	COG1518	maintenance of DNA repeat elements
M28_RS06675	COG5433	transposase activity
M28_RS06730	COG0433	COG0433 Predicted ATPase
M28_RS06780	COG1674	ftsk spoiiie
M28_RS06820	COG1396	sequence-specific DNA binding
M28_RS06860	COG1605	Chorismate mutase
M28_RS06860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M28_RS06880	COG2226	methyltransferase
M28_RS06890	COG3250	beta-galactosidase activity
M28_RS06895	COG4753	response regulator
M28_RS06895	COG2207	Transcriptional regulator
M28_RS06900	COG2972	Histidine kinase
M28_RS06910	COG1653	transport
M28_RS06915	COG0395	ABC-type sugar transport system, permease component
M28_RS06920	COG1175	transmembrane transport
M28_RS06935	COG2723	6-phospho-beta-galactosidase activity
M28_RS06940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M28_RS06945	COG1609	Transcriptional regulator
M28_RS06955	COG0383	alpha-mannosidase activity
M28_RS07065	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M28_RS07070	COG1739	Uncharacterized protein family UPF0029
M28_RS07080	COG1098	S1 RNA binding domain
M28_RS07090	COG2197	response regulator
M28_RS07095	COG4585	Histidine kinase
M28_RS07105	COG0515	serine threonine protein kinase
M28_RS07105	COG2815	serine threonine protein kinase
M28_RS07115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M28_RS07115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M28_RS07125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M28_RS07145	COG0583	DNA-binding transcription factor activity
M28_RS07150	COG0183	Belongs to the thiolase family
M28_RS07155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M28_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
M28_RS07170	COG2610	gluconate transmembrane transporter activity
M28_RS07185	COG0116	Belongs to the methyltransferase superfamily
M28_RS07210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M28_RS07215	COG3579	cysteine-type endopeptidase activity
M28_RS07225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M28_RS07230	COG1113	amino acid transport
M28_RS07235	COG0492	ferredoxin-NADP+ reductase activity
M28_RS07245	COG1126	abc transporter atp-binding protein
M28_RS07255	COG0513	Belongs to the DEAD box helicase family
M28_RS07265	COG0768	penicillin binding
M28_RS07300	COG1131	(ABC) transporter
M28_RS07325	COG0446	pyridine nucleotide-disulphide oxidoreductase
M28_RS07330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M28_RS07370	COG1755	Isoprenylcysteine carboxyl methyltransferase
M28_RS07375	COG0656	L-ascorbic acid biosynthetic process
M28_RS07385	COG1283	sodium-dependent phosphate transmembrane transporter activity
M28_RS07405	COG0561	phosphatase activity
M28_RS07410	COG2860	membrane
M28_RS07465	COG2217	Heavy metal translocating P-type atpase
M28_RS07495	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M28_RS07500	COG0195	Participates in both transcription termination and antitermination
M28_RS07525	COG4473	ABC transporter
M28_RS07530	COG1131	(ABC) transporter
M28_RS07535	COG0537	adenosine 5'-monophosphoramidase activity
M28_RS07545	COG1316	TRANSCRIPTIONal
M28_RS07555	COG0802	atpase or kinase
M28_RS07560	COG2252	PERMEase
M28_RS07565	COG0561	phosphatase activity
M28_RS07575	COG3715	PTS system
M28_RS07580	COG3716	PTS system mannose fructose sorbose family IID component
M28_RS07605	COG0439	Biotin carboxylase
M28_RS07620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M28_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
M28_RS07630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M28_RS07655	COG1024	Enoyl-CoA hydratase
M28_RS07690	COG0588	phosphoglycerate mutase activity
M28_RS07695	COG2261	transglycosylase associated protein
M28_RS07730	COG1335	isochorismatase
M28_RS07740	COG0436	Aminotransferase
M28_RS07750	COG0561	phosphatase activity
M28_RS07755	COG0252	asparaginase activity
M28_RS07770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M28_RS07780	COG1129	ABC transporter
M28_RS07795	COG1132	(ABC) transporter
M28_RS07800	COG1132	(ABC) transporter
M28_RS07805	COG1120	ATPase activity
M28_RS07830	COG1388	LysM domain
M28_RS07830	COG3942	CHAP domain
M28_RS07850	COG1482	cell wall glycoprotein biosynthetic process
M28_RS07855	COG1940	carbohydrate kinase activity
M28_RS07865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M28_RS07865	COG1263	PTS System
M28_RS07865	COG2190	(PTS) system
M28_RS07870	COG1621	beta-fructofuranosidase activity
M28_RS07875	COG1609	Transcriptional regulator
M28_RS07895	COG2131	deaminase
M28_RS07900	COG0006	proline dipeptidase activity
M28_RS07940	COG1194	a g-specific adenine glycosylase
M28_RS07950	COG3118	belongs to the thioredoxin family
M28_RS07980	COG0681	Belongs to the peptidase S26 family
M28_RS07985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M28_RS08000	COG1882	Formate acetyltransferase
M28_RS08005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M28_RS08020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M28_RS08030	COG2814	Major facilitator Superfamily
M28_RS08035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M28_RS08060	COG0789	Transcriptional regulator
M28_RS08095	COG2081	HI0933 family
M28_RS08105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M28_RS08110	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M28_RS08130	COG0456	acetyltransferase
M28_RS08135	COG1214	PFAM Peptidase M22, glycoprotease
M28_RS08150	COG0174	glutamine synthetase
M28_RS08155	COG0789	Transcriptional regulator
M28_RS08170	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M28_RS08225	COG0668	transmembrane transport
M28_RS08235	COG4720	Psort location CytoplasmicMembrane, score
M28_RS08240	COG0351	phosphomethylpyrimidine kinase
M28_RS08285	COG1929	Belongs to the glycerate kinase type-1 family
M28_RS08290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M28_RS08320	COG0577	efflux transmembrane transporter activity
M28_RS08325	COG1136	(ABC) transporter
M28_RS08350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M28_RS08350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M28_RS08355	COG1447	Phosphotransferase system cellobiose-specific component IIA
M28_RS08405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M28_RS08410	COG1476	TRANSCRIPTIONal
M28_RS08430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M28_RS08440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M28_RS08460	COG1045	serine acetyltransferase
M28_RS08475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M28_RS08490	COG3711	transcriptional antiterminator
M28_RS08515	COG0431	NADPH-dependent FMN reductase
M28_RS08520	COG1846	Transcriptional regulator
M28_RS08540	COG4589	Belongs to the CDS family
M28_RS08550	COG1862	Preprotein translocase
M28_RS08560	COG1523	belongs to the glycosyl hydrolase 13 family
M28_RS08575	COG3842	ATPase activity
M28_RS08615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M28_RS08615	COG2190	(PTS) system
M28_RS08615	COG1263	PTS System
M28_RS08620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M28_RS08635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M28_RS08640	COG0512	Glutamine amidotransferase of anthranilate synthase
M28_RS08645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M28_RS08680	COG0601	transmembrane transport
M28_RS08690	COG1122	ATPase activity
M28_RS08710	COG0803	Belongs to the bacterial solute-binding protein 9 family
M28_RS08715	COG5433	transposase activity
M28_RS08745	COG3711	transcriptional antiterminator
M28_RS08760	COG1705	Flagellar rod assembly protein muramidase FlgJ
M28_RS08760	COG3942	CHAP domain
M28_RS08765	COG2205	protein histidine kinase activity
M28_RS08770	COG0745	RESPONSE REGULATOR receiver
M28_RS08775	COG0577	efflux transmembrane transporter activity
M28_RS08780	COG1136	(ABC) transporter
M28_RS08855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M28_RS08870	COG1882	Formate acetyltransferase
M28_RS08875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M28_RS08880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M28_RS08885	COG1447	Phosphotransferase system cellobiose-specific component IIA
M28_RS08890	COG2390	Transcriptional regulator
M28_RS08895	COG1349	DNA-binding transcription factor activity
M28_RS08900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M28_RS08920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M28_RS08935	COG0564	pseudouridine synthase activity
M28_RS08970	COG0542	response to heat
M28_RS08975	COG4463	regulation of RNA biosynthetic process
M28_RS08990	COG0450	alkyl hydroperoxide reductase
M28_RS09005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M28_RS09015	COG3404	Formiminotransferase-cyclodeaminase
M28_RS09030	COG0531	amino acid
M28_RS09060	COG3590	peptidase
M28_RS09065	COG0366	Alpha amylase catalytic
M28_RS09070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M28_RS09070	COG1263	PTS System
M28_RS09075	COG2188	Transcriptional regulator
M28_RS09090	COG2514	catechol 2,3-dioxygenase activity
M28_RS09100	COG0602	queuosine metabolic process
M28_RS09115	COG1328	CTP reductase activity
M28_RS09140	COG1393	Belongs to the ArsC family
M28_RS09155	COG0519	Catalyzes the synthesis of GMP from XMP
M28_RS09175	COG0582	viral genome integration into host DNA
M28_RS09315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M28_RS09320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M28_RS09325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M28_RS09410	COG1511	domain protein
M28_RS09530	COG0582	viral genome integration into host DNA
M28_RS09545	COG0305	Participates in initiation and elongation during chromosome replication
M28_RS09575	COG1760	l-serine dehydratase
M28_RS09580	COG1760	l-serine dehydratase
M28_RS09585	COG0741	lytic transglycosylase activity
M28_RS09590	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M28_RS09605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M28_RS09615	COG0612	Peptidase, M16
M28_RS09635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M28_RS09655	COG0516	GMP reductase activity
M28_RS09655	COG0517	IMP dehydrogenase activity
M28_RS09665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M28_RS09670	COG0488	(ABC) transporter
M28_RS09705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M28_RS09710	COG1475	DNA binding