locus-tag	class	description
SPYM18_RS00010	COG0592	DNA-directed DNA polymerase activity
SPYM18_RS00020	COG0012	GTP binding
SPYM18_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYM18_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYM18_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYM18_RS00065	COG0531	amino acid
SPYM18_RS00240	COG3942	CHAP domain
SPYM18_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYM18_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYM18_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYM18_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYM18_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYM18_RS00335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYM18_RS00350	COG1454	alcohol dehydrogenase
SPYM18_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
SPYM18_RS00355	COG1064	alcohol dehydrogenase
SPYM18_RS00360	COG0534	Mate efflux family protein
SPYM18_RS00470	COG0201	protein transport
SPYM18_RS00605	COG1121	(ABC) transporter
SPYM18_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYM18_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM18_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYM18_RS00650	COG1459	type II secretion system
SPYM18_RS00655	COG4537	Required for transformation and DNA binding
SPYM18_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYM18_RS00700	COG1363	Peptidase, m42
SPYM18_RS00715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYM18_RS00720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYM18_RS00730	COG1428	Deoxynucleoside kinase
SPYM18_RS00735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYM18_RS00765	COG4509	Sortase family
SPYM18_RS00790	COG2031	fatty acid transporter
SPYM18_RS00805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYM18_RS00820	COG0251	oxidation-reduction process
SPYM18_RS00835	COG1269	ATP hydrolysis coupled proton transport
SPYM18_RS00840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYM18_RS00850	COG1527	subunit (C
SPYM18_RS00855	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYM18_RS00890	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYM18_RS00930	COG0626	cystathionine gamma-synthase activity
SPYM18_RS00960	COG3623	hexulose-6-phosphate isomerase
SPYM18_RS00980	COG3448	diguanylate cyclase activity
SPYM18_RS00980	COG4175	Glycine betaine
SPYM18_RS00990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYM18_RS00990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYM18_RS01020	COG1268	BioY protein
SPYM18_RS01025	COG1234	tRNA 3'-trailer cleavage
SPYM18_RS01060	COG0705	Rhomboid family
SPYM18_RS01060	COG0457	Tetratricopeptide repeat
SPYM18_RS01080	COG1132	(ABC) transporter
SPYM18_RS01085	COG1132	(ABC) transporter
SPYM18_RS01095	COG0756	dUTP diphosphatase activity
SPYM18_RS01120	COG3290	protein histidine kinase activity
SPYM18_RS01145	COG1847	R3H domain protein
SPYM18_RS01165	COG1175	transmembrane transport
SPYM18_RS01170	COG0395	ABC-type sugar transport system, permease component
SPYM18_RS01185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYM18_RS01200	COG0084	hydrolase, TatD family'
SPYM18_RS01225	COG1564	THIamine pyrophosphokinase
SPYM18_RS01245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYM18_RS01280	COG0765	amino acid transport
SPYM18_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYM18_RS01310	COG0719	Fe-S assembly protein
SPYM18_RS01315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYM18_RS01330	COG1686	Belongs to the peptidase S11 family
SPYM18_RS01335	COG1686	Belongs to the peptidase S11 family
SPYM18_RS01340	COG4166	transmembrane transport
SPYM18_RS01345	COG0601	transmembrane transport
SPYM18_RS01350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYM18_RS01355	COG0444	Belongs to the ABC transporter superfamily
SPYM18_RS01400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYM18_RS01405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYM18_RS01410	COG1534	Rna-binding protein
SPYM18_RS01420	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYM18_RS01425	COG0799	negative regulation of ribosome biogenesis
SPYM18_RS01430	COG2226	methyltransferase
SPYM18_RS01445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM18_RS01450	COG1464	Belongs to the NlpA lipoprotein family
SPYM18_RS01465	COG1114	Component of the transport system for branched-chain amino acids
SPYM18_RS01475	COG0569	domain protein
SPYM18_RS01480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYM18_RS01490	COG1704	LemA family
SPYM18_RS01505	COG0745	RESPONSE REGULATOR receiver
SPYM18_RS01525	COG1484	DNA-dependent DNA replication
SPYM18_RS01535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYM18_RS01595	COG0305	Participates in initiation and elongation during chromosome replication
SPYM18_RS01605	COG1484	DNA-dependent DNA replication
SPYM18_RS01665	COG0582	viral genome integration into host DNA
SPYM18_RS01710	COG0740	serine-type endopeptidase activity
SPYM18_RS01835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYM18_RS01850	COG1254	Belongs to the acylphosphatase family
SPYM18_RS01855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYM18_RS01910	COG1187	pseudouridine synthase activity
SPYM18_RS01935	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYM18_RS01940	COG0671	phosphoesterase, PA-phosphatase related
SPYM18_RS01945	COG1242	4 iron, 4 sulfur cluster binding
SPYM18_RS01950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYM18_RS01955	COG1253	flavin adenine dinucleotide binding
SPYM18_RS01960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYM18_RS01975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYM18_RS01980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYM18_RS01985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYM18_RS01990	COG1120	ATPase activity
SPYM18_RS02000	COG2244	polysaccharide biosynthetic process
SPYM18_RS02025	COG0470	DNA polymerase III
SPYM18_RS02055	COG1393	Belongs to the ArsC family
SPYM18_RS02060	COG0708	Exodeoxyribonuclease III
SPYM18_RS02065	COG1304	FMN binding
SPYM18_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM18_RS02130	COG0673	inositol 2-dehydrogenase activity
SPYM18_RS02145	COG0494	nUDIX hydrolase
SPYM18_RS02155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYM18_RS02245	COG1702	phosphate starvation-inducible protein PhoH
SPYM18_RS02250	COG1573	uracil-dna glycosylase
SPYM18_RS02260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYM18_RS02275	COG2274	protein secretion by the type I secretion system
SPYM18_RS02280	COG2274	protein secretion by the type I secretion system
SPYM18_RS02310	COG2801	Transposase and inactivated derivatives
SPYM18_RS02315	COG2801	Transposase and inactivated derivatives
SPYM18_RS02320	COG2801	Transposase and inactivated derivatives
SPYM18_RS02330	COG3279	Response regulator of the LytR AlgR family
SPYM18_RS02345	COG2274	protein secretion by the type I secretion system
SPYM18_RS02410	COG0433	COG0433 Predicted ATPase
SPYM18_RS02415	COG2814	Major facilitator Superfamily
SPYM18_RS02425	COG0557	exoribonuclease II activity
SPYM18_RS02455	COG0463	Glycosyl transferase, family 2
SPYM18_RS02465	COG0778	Nitroreductase
SPYM18_RS02470	COG0006	proline dipeptidase activity
SPYM18_RS02480	COG1609	Transcriptional regulator
SPYM18_RS02490	COG0438	transferase activity, transferring glycosyl groups
SPYM18_RS02505	COG4555	ABC transporter
SPYM18_RS02520	COG2376	Dihydroxyacetone kinase
SPYM18_RS02530	COG2376	Dihydroxyacetone kinase
SPYM18_RS02535	COG1461	Dihydroxyacetone kinase
SPYM18_RS02540	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPYM18_RS02545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM18_RS02555	COG0183	Belongs to the thiolase family
SPYM18_RS02570	COG0745	RESPONSE REGULATOR receiver
SPYM18_RS02575	COG5002	protein histidine kinase activity
SPYM18_RS02580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYM18_RS02590	COG1196	nuclear chromosome segregation
SPYM18_RS02600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYM18_RS02675	COG4695	Portal protein
SPYM18_RS02730	COG0561	phosphatase activity
SPYM18_RS02735	COG0561	phosphatase activity
SPYM18_RS02740	COG0552	protein localization to endoplasmic reticulum
SPYM18_RS02745	COG0477	Major facilitator Superfamily
SPYM18_RS02750	COG3711	transcriptional antiterminator
SPYM18_RS02755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM18_RS02755	COG2190	(PTS) system
SPYM18_RS02755	COG1263	PTS System
SPYM18_RS02765	COG3689	TIGRFAM TIGR03943 family protein
SPYM18_RS02770	COG0701	Predicted permease
SPYM18_RS02780	COG2183	response to ionizing radiation
SPYM18_RS02825	COG0826	peptidase U32
SPYM18_RS02830	COG4443	Transcriptional Coactivator p15 (PC4)
SPYM18_RS02880	COG0386	Belongs to the glutathione peroxidase family
SPYM18_RS02885	COG1164	Oligoendopeptidase f
SPYM18_RS02895	COG0772	Belongs to the SEDS family
SPYM18_RS02930	COG1078	dGTPase activity
SPYM18_RS02945	COG1609	Transcriptional regulator
SPYM18_RS02955	COG3716	PTS system mannose fructose sorbose family IID component
SPYM18_RS02960	COG3715	PTS system
SPYM18_RS02965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM18_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM18_RS02995	COG0800	Aldolase
SPYM18_RS03000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPYM18_RS03005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYM18_RS03015	COG2884	Cell division ATP-binding protein ftsE
SPYM18_RS03020	COG2177	Part of the ABC transporter FtsEX involved in
SPYM18_RS03035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYM18_RS03035	COG1199	ATP-dependent helicase activity
SPYM18_RS03040	COG0436	Aminotransferase
SPYM18_RS03075	COG3620	sequence-specific DNA binding
SPYM18_RS03130	COG3723	Recombinational DNA repair protein, rece pathway
SPYM18_RS03210	COG1598	PFAM Uncharacterised protein family UPF0150
SPYM18_RS03250	COG0740	serine-type endopeptidase activity
SPYM18_RS03345	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM18_RS03370	COG2188	Transcriptional regulator
SPYM18_RS03375	COG2222	sugar isomerase
SPYM18_RS03385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYM18_RS03390	COG0716	FMN binding
SPYM18_RS03400	COG0038	chloride channel
SPYM18_RS03475	COG1131	(ABC) transporter
SPYM18_RS03495	COG4708	membrane
SPYM18_RS03505	COG1597	lipid kinase activity
SPYM18_RS03590	COG0577	efflux transmembrane transporter activity
SPYM18_RS03600	COG2321	neutral zinc metallopeptidase
SPYM18_RS03615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM18_RS03625	COG1970	mechanosensitive ion channel activity
SPYM18_RS03630	COG0358	DNA primase activity
SPYM18_RS03635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYM18_RS03640	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYM18_RS03685	COG1216	Glycosyl transferase, family 2
SPYM18_RS03740	COG1368	sulfuric ester hydrolase activity
SPYM18_RS03745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYM18_RS03765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYM18_RS03770	COG0285	dihydrofolate synthase activity
SPYM18_RS03780	COG1104	cysteine desulfurase activity
SPYM18_RS03810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYM18_RS03815	COG0583	DNA-binding transcription factor activity
SPYM18_RS03825	COG0564	pseudouridine synthase activity
SPYM18_RS03855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYM18_RS03860	COG1136	(ABC) transporter
SPYM18_RS03865	COG0577	efflux transmembrane transporter activity
SPYM18_RS03870	COG0584	glycerophosphoryl diester phosphodiesterase
SPYM18_RS03880	COG1837	Belongs to the UPF0109 family
SPYM18_RS03930	COG1349	DNA-binding transcription factor activity
SPYM18_RS03935	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYM18_RS03940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYM18_RS03940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYM18_RS03940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYM18_RS03945	COG1388	LysM domain
SPYM18_RS03945	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM18_RS03950	COG1388	LysM domain
SPYM18_RS03950	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM18_RS03955	COG2801	Transposase and inactivated derivatives
SPYM18_RS03970	COG0105	UTP biosynthetic process
SPYM18_RS03990	COG0488	(ABC) transporter
SPYM18_RS04000	COG0242	peptide deformylase activity
SPYM18_RS04005	COG0737	Belongs to the 5'-nucleotidase family
SPYM18_RS04010	COG2357	RelA SpoT domain protein
SPYM18_RS04015	COG0745	RESPONSE REGULATOR receiver
SPYM18_RS04050	COG3425	synthase
SPYM18_RS04060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYM18_RS04105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPYM18_RS04120	COG0583	DNA-binding transcription factor activity
SPYM18_RS04145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM18_RS04150	COG0765	amino acid transport
SPYM18_RS04170	COG0187	DNA topoisomerase II activity
SPYM18_RS04180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYM18_RS04200	COG0539	negative regulation of cytoplasmic translation
SPYM18_RS04235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYM18_RS04240	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYM18_RS04250	COG0300	oxidoreductase activity
SPYM18_RS04255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYM18_RS04255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYM18_RS04270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYM18_RS04275	COG2384	SAM-dependent methyltransferase
SPYM18_RS04285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYM18_RS04290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYM18_RS04300	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYM18_RS04305	COG1051	belongs to the nudix hydrolase family
SPYM18_RS04310	COG0628	permease
SPYM18_RS04315	COG0457	Tetratricopeptide repeat
SPYM18_RS04320	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYM18_RS04335	COG1129	ABC transporter
SPYM18_RS04355	COG0488	(ABC) transporter
SPYM18_RS04360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYM18_RS04365	COG0022	dehydrogenase e1 component
SPYM18_RS04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYM18_RS04370	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYM18_RS04385	COG5492	domain, Protein
SPYM18_RS04390	COG0095	Lipoate-protein ligase
SPYM18_RS04395	COG3442	glutamine amidotransferase
SPYM18_RS04400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYM18_RS04405	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYM18_RS04425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYM18_RS04435	COG0647	UMP catabolic process
SPYM18_RS04475	COG3715	PTS system
SPYM18_RS04480	COG3716	PTS system mannose fructose sorbose family IID component
SPYM18_RS04485	COG2972	Histidine kinase
SPYM18_RS04490	COG2207	Transcriptional regulator
SPYM18_RS04490	COG4753	response regulator
SPYM18_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
SPYM18_RS04515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYM18_RS04555	COG0285	dihydrofolate synthase activity
SPYM18_RS04590	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYM18_RS04595	COG1177	transmembrane transport
SPYM18_RS04605	COG4565	transcriptional regulatory protein
SPYM18_RS04610	COG3290	protein histidine kinase activity
SPYM18_RS04615	COG3493	citrate carrier protein
SPYM18_RS04630	COG3700	Belongs to the class B bacterial acid phosphatase family
SPYM18_RS04635	COG0038	chloride channel
SPYM18_RS04655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYM18_RS04670	COG1104	cysteine desulfurase activity
SPYM18_RS04685	COG2357	RelA SpoT domain protein
SPYM18_RS04695	COG0564	pseudouridine synthase activity
SPYM18_RS04700	COG0280	phosphate acetyltransferase
SPYM18_RS04705	COG4221	oxidoreductase activity
SPYM18_RS04720	COG1174	glycine betaine transport
SPYM18_RS04735	COG2233	PERMEase
SPYM18_RS04760	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYM18_RS04790	COG1132	(ABC) transporter
SPYM18_RS04795	COG1132	(ABC) transporter
SPYM18_RS04815	COG3764	Sortase (surface protein transpeptidase)
SPYM18_RS04820	COG0346	lactoylglutathione lyase activity
SPYM18_RS04835	COG1272	protein, Hemolysin III
SPYM18_RS04855	COG0758	DNA mediated transformation
SPYM18_RS04860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYM18_RS04880	COG0511	ligase activity, forming carbon-carbon bonds
SPYM18_RS04885	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYM18_RS04900	COG2851	Citrate transporter
SPYM18_RS04910	COG0511	ligase activity, forming carbon-carbon bonds
SPYM18_RS04915	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYM18_RS04950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYM18_RS04970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYM18_RS04980	COG2188	Transcriptional regulator
SPYM18_RS05000	COG0488	(ABC) transporter
SPYM18_RS05010	COG0352	thiamine-phosphate diphosphorylase activity
SPYM18_RS05010	COG0351	phosphomethylpyrimidine kinase
SPYM18_RS05015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYM18_RS05020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYM18_RS05020	COG1328	CTP reductase activity
SPYM18_RS05025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYM18_RS05055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYM18_RS05065	COG0095	Lipoate-protein ligase
SPYM18_RS05075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYM18_RS05080	COG4684	Psort location CytoplasmicMembrane, score
SPYM18_RS05085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYM18_RS05090	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYM18_RS05095	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYM18_RS05100	COG3845	ABC transporter
SPYM18_RS05105	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYM18_RS05110	COG0295	cytidine deaminase activity
SPYM18_RS05115	COG2813	Specifically methylates the guanine in position
SPYM18_RS05130	COG5002	protein histidine kinase activity
SPYM18_RS05135	COG0745	RESPONSE REGULATOR receiver
SPYM18_RS05145	COG0704	Plays a role in the regulation of phosphate uptake
SPYM18_RS05160	COG0581	inorganic phosphate transmembrane transporter activity
SPYM18_RS05165	COG0573	inorganic phosphate transmembrane transporter activity
SPYM18_RS05175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYM18_RS05175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYM18_RS05180	COG0483	inositol monophosphate 1-phosphatase activity
SPYM18_RS05195	COG0196	riboflavin kinase activity
SPYM18_RS05225	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYM18_RS05225	COG1136	(ABC) transporter
SPYM18_RS05275	COG1115	amino acid carrier protein
SPYM18_RS05280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYM18_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM18_RS05295	COG1126	abc transporter atp-binding protein
SPYM18_RS05300	COG0765	amino acid transport
SPYM18_RS05305	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYM18_RS05320	COG0469	pyruvate kinase activity
SPYM18_RS05335	COG1725	Transcriptional regulator
SPYM18_RS05340	COG1131	(ABC) transporter
SPYM18_RS05380	COG1388	LysM domain
SPYM18_RS05380	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYM18_RS05390	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM18_RS05660	COG1396	sequence-specific DNA binding
SPYM18_RS05690	COG0058	SHG alpha-glucan phosphorylase activity
SPYM18_RS05695	COG1640	4-alpha-glucanotransferase
SPYM18_RS05700	COG1609	Transcriptional regulator
SPYM18_RS05705	COG2182	Extracellular solute-binding protein
SPYM18_RS05710	COG1175	transmembrane transport
SPYM18_RS05715	COG3833	ABC-type maltose transport systems, permease component
SPYM18_RS05730	COG0657	acetylesterase activity
SPYM18_RS05735	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYM18_RS05745	COG1696	Membrane protein involved in D-alanine export
SPYM18_RS05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM18_RS05770	COG1126	abc transporter atp-binding protein
SPYM18_RS05775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM18_RS05785	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM18_RS05795	COG3711	transcriptional antiterminator
SPYM18_RS05795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYM18_RS05805	COG2723	6-phospho-beta-galactosidase activity
SPYM18_RS05830	COG2801	Transposase and inactivated derivatives
SPYM18_RS05835	COG0157	Belongs to the NadC ModD family
SPYM18_RS05850	COG2801	Transposase and inactivated derivatives
SPYM18_RS05855	COG1187	pseudouridine synthase activity
SPYM18_RS05865	COG2814	Major facilitator Superfamily
SPYM18_RS05915	COG4109	DRTGG domain
SPYM18_RS05945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYM18_RS05945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYM18_RS05950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYM18_RS05955	COG1956	GAF domain-containing protein
SPYM18_RS05975	COG0513	Belongs to the DEAD box helicase family
SPYM18_RS05980	COG0726	polysaccharide deacetylase
SPYM18_RS06000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYM18_RS06005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYM18_RS06025	COG2801	Transposase and inactivated derivatives
SPYM18_RS06030	COG2801	Transposase and inactivated derivatives
SPYM18_RS06045	COG1476	TRANSCRIPTIONal
SPYM18_RS06065	COG4122	O-methyltransferase activity
SPYM18_RS06070	COG2223	nitrite transmembrane transporter activity
SPYM18_RS06085	COG1187	pseudouridine synthase activity
SPYM18_RS06125	COG2333	competence protein COMEC
SPYM18_RS06125	COG0658	competence protein
SPYM18_RS06130	COG1596	polysaccharide export
SPYM18_RS06130	COG1555	photosystem II stabilization
SPYM18_RS06135	COG0204	Acyl-transferase
SPYM18_RS06140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPYM18_RS06155	COG0513	Belongs to the DEAD box helicase family
SPYM18_RS06170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYM18_RS06195	COG1827	regulation of RNA biosynthetic process
SPYM18_RS06210	COG2217	Heavy metal translocating P-type atpase
SPYM18_RS06430	COG3723	Recombinational DNA repair protein, rece pathway
SPYM18_RS06475	COG1396	sequence-specific DNA binding
SPYM18_RS06485	COG0582	viral genome integration into host DNA
SPYM18_RS06500	COG2755	lipolytic protein G-D-S-L family
SPYM18_RS06515	COG0497	DNA recombination
SPYM18_RS06520	COG1438	arginine binding
SPYM18_RS06525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYM18_RS06550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYM18_RS06555	COG0415	Belongs to the DNA photolyase family
SPYM18_RS06565	COG0765	amino acid transport
SPYM18_RS06570	COG4703	Protein of unknown function (DUF1797)
SPYM18_RS06575	COG0542	response to heat
SPYM18_RS06580	COG0494	nUDIX hydrolase
SPYM18_RS06595	COG3599	regulation of cell shape
SPYM18_RS06600	COG2302	S4 RNA-binding domain
SPYM18_RS06615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYM18_RS06650	COG1217	gtp-binding protein TYPA
SPYM18_RS06655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYM18_RS06660	COG1940	carbohydrate kinase activity
SPYM18_RS06670	COG0783	Belongs to the Dps family
SPYM18_RS06685	COG4470	Protein conserved in bacteria
SPYM18_RS06690	COG1609	Transcriptional regulator
SPYM18_RS06695	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYM18_RS06705	COG0742	ribosomal rna small subunit methyltransferase
SPYM18_RS06715	COG0549	Belongs to the carbamate kinase family
SPYM18_RS06720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYM18_RS06725	COG1288	antiporter activity
SPYM18_RS06735	COG0454	-acetyltransferase
SPYM18_RS06740	COG2235	arginine
SPYM18_RS06765	COG2972	Histidine kinase
SPYM18_RS06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYM18_RS06785	COG0785	Cytochrome C biogenesis protein
SPYM18_RS06795	COG0673	inositol 2-dehydrogenase activity
SPYM18_RS06835	COG1605	Chorismate mutase
SPYM18_RS06835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYM18_RS06855	COG2226	methyltransferase
SPYM18_RS06865	COG3250	beta-galactosidase activity
SPYM18_RS06870	COG4753	response regulator
SPYM18_RS06870	COG2207	Transcriptional regulator
SPYM18_RS06875	COG2972	Histidine kinase
SPYM18_RS06885	COG1653	transport
SPYM18_RS06890	COG0395	ABC-type sugar transport system, permease component
SPYM18_RS06895	COG1175	transmembrane transport
SPYM18_RS06905	COG2723	6-phospho-beta-galactosidase activity
SPYM18_RS06910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYM18_RS06925	COG0383	alpha-mannosidase activity
SPYM18_RS07020	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPYM18_RS07025	COG1739	Uncharacterized protein family UPF0029
SPYM18_RS07035	COG1098	S1 RNA binding domain
SPYM18_RS07045	COG2197	response regulator
SPYM18_RS07050	COG4585	Histidine kinase
SPYM18_RS07060	COG2815	serine threonine protein kinase
SPYM18_RS07060	COG0515	serine threonine protein kinase
SPYM18_RS07070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYM18_RS07070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYM18_RS07080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYM18_RS07100	COG0583	DNA-binding transcription factor activity
SPYM18_RS07105	COG0183	Belongs to the thiolase family
SPYM18_RS07110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYM18_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM18_RS07140	COG0116	Belongs to the methyltransferase superfamily
SPYM18_RS07160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM18_RS07165	COG3579	cysteine-type endopeptidase activity
SPYM18_RS07175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYM18_RS07180	COG1113	amino acid transport
SPYM18_RS07185	COG0492	ferredoxin-NADP+ reductase activity
SPYM18_RS07195	COG1126	abc transporter atp-binding protein
SPYM18_RS07205	COG0513	Belongs to the DEAD box helicase family
SPYM18_RS07215	COG0768	penicillin binding
SPYM18_RS07250	COG1131	(ABC) transporter
SPYM18_RS07275	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYM18_RS07280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM18_RS07315	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYM18_RS07320	COG0656	L-ascorbic acid biosynthetic process
SPYM18_RS07330	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYM18_RS07350	COG0561	phosphatase activity
SPYM18_RS07355	COG2860	membrane
SPYM18_RS07380	COG3775	system Galactitol-specific IIC component
SPYM18_RS07405	COG2217	Heavy metal translocating P-type atpase
SPYM18_RS07435	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYM18_RS07440	COG0195	Participates in both transcription termination and antitermination
SPYM18_RS07465	COG4473	ABC transporter
SPYM18_RS07470	COG1131	(ABC) transporter
SPYM18_RS07475	COG0537	adenosine 5'-monophosphoramidase activity
SPYM18_RS07485	COG1316	TRANSCRIPTIONal
SPYM18_RS07495	COG0802	atpase or kinase
SPYM18_RS07500	COG2252	PERMEase
SPYM18_RS07525	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYM18_RS07525	COG1388	LysM domain
SPYM18_RS07670	COG1475	DNA binding
SPYM18_RS07785	COG3561	AntA/AntB antirepressor
SPYM18_RS07815	COG0561	phosphatase activity
SPYM18_RS07825	COG3715	PTS system
SPYM18_RS07830	COG3716	PTS system mannose fructose sorbose family IID component
SPYM18_RS07855	COG0439	Biotin carboxylase
SPYM18_RS07870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYM18_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM18_RS07880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYM18_RS07905	COG1024	Enoyl-CoA hydratase
SPYM18_RS07940	COG0588	phosphoglycerate mutase activity
SPYM18_RS07945	COG2261	transglycosylase associated protein
SPYM18_RS07970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYM18_RS07970	COG0574	Belongs to the PEP-utilizing enzyme family
SPYM18_RS07975	COG1335	isochorismatase
SPYM18_RS07985	COG0436	Aminotransferase
SPYM18_RS07995	COG0561	phosphatase activity
SPYM18_RS08000	COG0252	asparaginase activity
SPYM18_RS08015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYM18_RS08020	COG1129	ABC transporter
SPYM18_RS08035	COG1132	(ABC) transporter
SPYM18_RS08040	COG4988	ABC transporter
SPYM18_RS08070	COG3942	CHAP domain
SPYM18_RS08070	COG1388	LysM domain
SPYM18_RS08095	COG1482	cell wall glycoprotein biosynthetic process
SPYM18_RS08100	COG1940	carbohydrate kinase activity
SPYM18_RS08110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM18_RS08110	COG1263	PTS System
SPYM18_RS08110	COG2190	(PTS) system
SPYM18_RS08115	COG1621	beta-fructofuranosidase activity
SPYM18_RS08120	COG1609	Transcriptional regulator
SPYM18_RS08140	COG2131	deaminase
SPYM18_RS08145	COG0006	proline dipeptidase activity
SPYM18_RS08185	COG1194	a g-specific adenine glycosylase
SPYM18_RS08190	COG3620	sequence-specific DNA binding
SPYM18_RS08195	COG3118	belongs to the thioredoxin family
SPYM18_RS08225	COG0681	Belongs to the peptidase S26 family
SPYM18_RS08230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYM18_RS08245	COG1882	Formate acetyltransferase
SPYM18_RS08250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYM18_RS08265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM18_RS08275	COG2814	Major facilitator Superfamily
SPYM18_RS08280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYM18_RS08305	COG0789	Transcriptional regulator
SPYM18_RS08320	COG2081	HI0933 family
SPYM18_RS08330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYM18_RS08335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYM18_RS08355	COG0456	acetyltransferase
SPYM18_RS08360	COG1214	PFAM Peptidase M22, glycoprotease
SPYM18_RS08375	COG0174	glutamine synthetase
SPYM18_RS08380	COG0789	Transcriptional regulator
SPYM18_RS08395	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYM18_RS08450	COG0668	transmembrane transport
SPYM18_RS08460	COG4720	Psort location CytoplasmicMembrane, score
SPYM18_RS08465	COG0351	phosphomethylpyrimidine kinase
SPYM18_RS08515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYM18_RS08545	COG0577	efflux transmembrane transporter activity
SPYM18_RS08550	COG1136	(ABC) transporter
SPYM18_RS08570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM18_RS08570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM18_RS08575	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM18_RS08625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYM18_RS08630	COG1476	TRANSCRIPTIONal
SPYM18_RS08650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYM18_RS08660	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYM18_RS08675	COG1045	serine acetyltransferase
SPYM18_RS08690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYM18_RS08705	COG3711	transcriptional antiterminator
SPYM18_RS08735	COG1846	Transcriptional regulator
SPYM18_RS08755	COG4589	Belongs to the CDS family
SPYM18_RS08765	COG1862	Preprotein translocase
SPYM18_RS08775	COG1523	belongs to the glycosyl hydrolase 13 family
SPYM18_RS08785	COG3842	ATPase activity
SPYM18_RS08830	COG1263	PTS System
SPYM18_RS08830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM18_RS08830	COG2190	(PTS) system
SPYM18_RS08835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYM18_RS08850	COG0154	amidase activity
SPYM18_RS08855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYM18_RS08860	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYM18_RS08865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYM18_RS08900	COG0601	transmembrane transport
SPYM18_RS08930	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYM18_RS08945	COG3711	transcriptional antiterminator
SPYM18_RS08955	COG3942	CHAP domain
SPYM18_RS08955	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM18_RS08960	COG2205	protein histidine kinase activity
SPYM18_RS08965	COG0745	RESPONSE REGULATOR receiver
SPYM18_RS08970	COG0577	efflux transmembrane transporter activity
SPYM18_RS08975	COG1136	(ABC) transporter
SPYM18_RS09025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYM18_RS09040	COG1882	Formate acetyltransferase
SPYM18_RS09045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM18_RS09050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM18_RS09055	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM18_RS09060	COG2390	Transcriptional regulator
SPYM18_RS09065	COG1349	DNA-binding transcription factor activity
SPYM18_RS09070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYM18_RS09080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM18_RS09095	COG0564	pseudouridine synthase activity
SPYM18_RS09130	COG0542	response to heat
SPYM18_RS09135	COG4463	regulation of RNA biosynthetic process
SPYM18_RS09150	COG0450	alkyl hydroperoxide reductase
SPYM18_RS09165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYM18_RS09175	COG3404	Formiminotransferase-cyclodeaminase
SPYM18_RS09190	COG0531	amino acid
SPYM18_RS09220	COG3590	peptidase
SPYM18_RS09225	COG0366	Alpha amylase catalytic
SPYM18_RS09230	COG1263	PTS System
SPYM18_RS09230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM18_RS09235	COG2188	Transcriptional regulator
SPYM18_RS09240	COG1733	regulation of RNA biosynthetic process
SPYM18_RS09255	COG0602	queuosine metabolic process
SPYM18_RS09270	COG1328	CTP reductase activity
SPYM18_RS09295	COG1393	Belongs to the ArsC family
SPYM18_RS09310	COG0519	Catalyzes the synthesis of GMP from XMP
SPYM18_RS09355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM18_RS09360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM18_RS09365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM18_RS09460	COG1511	domain protein
SPYM18_RS09480	COG0305	Participates in initiation and elongation during chromosome replication
SPYM18_RS09510	COG1760	l-serine dehydratase
SPYM18_RS09515	COG1760	l-serine dehydratase
SPYM18_RS09520	COG0741	lytic transglycosylase activity
SPYM18_RS09525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYM18_RS09540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYM18_RS09550	COG0612	Peptidase, M16
SPYM18_RS09560	COG1215	transferase activity, transferring glycosyl groups
SPYM18_RS09565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPYM18_RS09570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPYM18_RS09590	COG0516	GMP reductase activity
SPYM18_RS09590	COG0517	IMP dehydrogenase activity
SPYM18_RS09600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM18_RS09640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYM18_RS09645	COG1475	DNA binding