locus-tag	class	description
MGAS9429_RS00010	COG0592	DNA-directed DNA polymerase activity
MGAS9429_RS00020	COG0012	GTP binding
MGAS9429_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MGAS9429_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MGAS9429_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MGAS9429_RS00065	COG0531	amino acid
MGAS9429_RS00240	COG3942	CHAP domain
MGAS9429_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGAS9429_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MGAS9429_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MGAS9429_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MGAS9429_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MGAS9429_RS00335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MGAS9429_RS00350	COG1454	alcohol dehydrogenase
MGAS9429_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
MGAS9429_RS00355	COG1064	alcohol dehydrogenase
MGAS9429_RS00360	COG0534	Mate efflux family protein
MGAS9429_RS00470	COG0201	protein transport
MGAS9429_RS00605	COG1121	(ABC) transporter
MGAS9429_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MGAS9429_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS9429_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MGAS9429_RS00650	COG1459	type II secretion system
MGAS9429_RS00655	COG4537	Required for transformation and DNA binding
MGAS9429_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MGAS9429_RS00700	COG1363	Peptidase, m42
MGAS9429_RS00710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS9429_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MGAS9429_RS00725	COG1428	Deoxynucleoside kinase
MGAS9429_RS00730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MGAS9429_RS00770	COG4509	Sortase family
MGAS9429_RS00795	COG2031	fatty acid transporter
MGAS9429_RS00810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS9429_RS00825	COG0251	oxidation-reduction process
MGAS9429_RS00840	COG1269	ATP hydrolysis coupled proton transport
MGAS9429_RS00845	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGAS9429_RS00855	COG1527	subunit (C
MGAS9429_RS00860	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MGAS9429_RS00895	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS9429_RS00935	COG0626	cystathionine gamma-synthase activity
MGAS9429_RS00965	COG3623	hexulose-6-phosphate isomerase
MGAS9429_RS00985	COG3448	diguanylate cyclase activity
MGAS9429_RS00985	COG4175	Glycine betaine
MGAS9429_RS00995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS9429_RS00995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MGAS9429_RS01015	COG3969	phosphoadenosine phosphosulfate
MGAS9429_RS01020	COG1475	DNA binding
MGAS9429_RS01030	COG2801	Transposase and inactivated derivatives
MGAS9429_RS01035	COG2801	Transposase and inactivated derivatives
MGAS9429_RS01050	COG0157	Belongs to the NadC ModD family
MGAS9429_RS01055	COG2801	Transposase and inactivated derivatives
MGAS9429_RS01075	COG1268	BioY protein
MGAS9429_RS01080	COG5433	transposase activity
MGAS9429_RS01090	COG1234	tRNA 3'-trailer cleavage
MGAS9429_RS01120	COG5433	transposase activity
MGAS9429_RS01130	COG0457	Tetratricopeptide repeat
MGAS9429_RS01130	COG0705	Rhomboid family
MGAS9429_RS01150	COG1132	(ABC) transporter
MGAS9429_RS01155	COG1132	(ABC) transporter
MGAS9429_RS01165	COG0756	dUTP diphosphatase activity
MGAS9429_RS01190	COG3290	protein histidine kinase activity
MGAS9429_RS01215	COG1847	R3H domain protein
MGAS9429_RS01235	COG1175	transmembrane transport
MGAS9429_RS01240	COG0395	ABC-type sugar transport system, permease component
MGAS9429_RS01250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MGAS9429_RS01265	COG0084	hydrolase, TatD family'
MGAS9429_RS01290	COG1564	THIamine pyrophosphokinase
MGAS9429_RS01305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGAS9429_RS01340	COG0765	amino acid transport
MGAS9429_RS01360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MGAS9429_RS01370	COG0719	Fe-S assembly protein
MGAS9429_RS01375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MGAS9429_RS01390	COG1686	Belongs to the peptidase S11 family
MGAS9429_RS01395	COG1686	Belongs to the peptidase S11 family
MGAS9429_RS01400	COG4166	transmembrane transport
MGAS9429_RS01405	COG0601	transmembrane transport
MGAS9429_RS01410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MGAS9429_RS01415	COG0444	Belongs to the ABC transporter superfamily
MGAS9429_RS01465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MGAS9429_RS01470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGAS9429_RS01475	COG1534	Rna-binding protein
MGAS9429_RS01485	COG1713	HD superfamily hydrolase involved in NAD metabolism
MGAS9429_RS01490	COG0799	negative regulation of ribosome biogenesis
MGAS9429_RS01495	COG2226	methyltransferase
MGAS9429_RS01510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_RS01515	COG1464	Belongs to the NlpA lipoprotein family
MGAS9429_RS01530	COG1114	Component of the transport system for branched-chain amino acids
MGAS9429_RS01540	COG0569	domain protein
MGAS9429_RS01545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MGAS9429_RS01555	COG1704	LemA family
MGAS9429_RS01570	COG0745	RESPONSE REGULATOR receiver
MGAS9429_RS01590	COG1484	DNA-dependent DNA replication
MGAS9429_RS01600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MGAS9429_RS01620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MGAS9429_RS01635	COG1254	Belongs to the acylphosphatase family
MGAS9429_RS01640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS9429_RS01695	COG1187	pseudouridine synthase activity
MGAS9429_RS01710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MGAS9429_RS01715	COG0671	phosphoesterase, PA-phosphatase related
MGAS9429_RS01720	COG1242	4 iron, 4 sulfur cluster binding
MGAS9429_RS01725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MGAS9429_RS01730	COG1253	flavin adenine dinucleotide binding
MGAS9429_RS01735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS9429_RS01750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS9429_RS01755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MGAS9429_RS01760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MGAS9429_RS01765	COG1120	ATPase activity
MGAS9429_RS01775	COG2244	polysaccharide biosynthetic process
MGAS9429_RS01795	COG5433	transposase activity
MGAS9429_RS01810	COG0470	DNA polymerase III
MGAS9429_RS01840	COG1393	Belongs to the ArsC family
MGAS9429_RS01845	COG0708	Exodeoxyribonuclease III
MGAS9429_RS01850	COG1304	FMN binding
MGAS9429_RS01925	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_RS01930	COG0673	inositol 2-dehydrogenase activity
MGAS9429_RS01945	COG0494	nUDIX hydrolase
MGAS9429_RS01955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MGAS9429_RS02015	COG2996	Protein conserved in bacteria
MGAS9429_RS02040	COG1702	phosphate starvation-inducible protein PhoH
MGAS9429_RS02045	COG1573	uracil-dna glycosylase
MGAS9429_RS02055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MGAS9429_RS02070	COG3328	transposase activity
MGAS9429_RS02135	COG0433	COG0433 Predicted ATPase
MGAS9429_RS02140	COG2814	Major facilitator Superfamily
MGAS9429_RS02150	COG0557	exoribonuclease II activity
MGAS9429_RS02180	COG0463	Glycosyl transferase, family 2
MGAS9429_RS02190	COG0778	Nitroreductase
MGAS9429_RS02195	COG0006	proline dipeptidase activity
MGAS9429_RS02200	COG1609	Transcriptional regulator
MGAS9429_RS02210	COG0438	transferase activity, transferring glycosyl groups
MGAS9429_RS02220	COG4555	ABC transporter
MGAS9429_RS02240	COG0183	Belongs to the thiolase family
MGAS9429_RS02255	COG0745	RESPONSE REGULATOR receiver
MGAS9429_RS02260	COG5002	protein histidine kinase activity
MGAS9429_RS02265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MGAS9429_RS02275	COG1196	nuclear chromosome segregation
MGAS9429_RS02285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MGAS9429_RS02380	COG0561	phosphatase activity
MGAS9429_RS02385	COG0561	phosphatase activity
MGAS9429_RS02390	COG0552	protein localization to endoplasmic reticulum
MGAS9429_RS02395	COG0477	Major facilitator Superfamily
MGAS9429_RS02400	COG3711	transcriptional antiterminator
MGAS9429_RS02405	COG1263	PTS System
MGAS9429_RS02405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_RS02405	COG2190	(PTS) system
MGAS9429_RS02415	COG3689	TIGRFAM TIGR03943 family protein
MGAS9429_RS02420	COG0701	Predicted permease
MGAS9429_RS02430	COG2183	response to ionizing radiation
MGAS9429_RS02475	COG0826	peptidase U32
MGAS9429_RS02480	COG4443	Transcriptional Coactivator p15 (PC4)
MGAS9429_RS02500	COG0588	phosphoglycerate mutase activity
MGAS9429_RS02530	COG0386	Belongs to the glutathione peroxidase family
MGAS9429_RS02535	COG1164	Oligoendopeptidase f
MGAS9429_RS02545	COG0772	Belongs to the SEDS family
MGAS9429_RS02580	COG1078	dGTPase activity
MGAS9429_RS02595	COG1609	Transcriptional regulator
MGAS9429_RS02605	COG3716	PTS system mannose fructose sorbose family IID component
MGAS9429_RS02610	COG3715	PTS system
MGAS9429_RS02615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_RS02645	COG0800	Aldolase
MGAS9429_RS02650	COG0546	phosphoglycolate phosphatase activity
MGAS9429_RS02655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MGAS9429_RS02665	COG2884	Cell division ATP-binding protein ftsE
MGAS9429_RS02670	COG2177	Part of the ABC transporter FtsEX involved in
MGAS9429_RS02685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MGAS9429_RS02685	COG1199	ATP-dependent helicase activity
MGAS9429_RS02690	COG0436	Aminotransferase
MGAS9429_RS02855	COG1598	PFAM Uncharacterised protein family UPF0150
MGAS9429_RS02895	COG0740	serine-type endopeptidase activity
MGAS9429_RS02990	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_RS03015	COG2188	Transcriptional regulator
MGAS9429_RS03020	COG2222	sugar isomerase
MGAS9429_RS03030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MGAS9429_RS03035	COG0716	FMN binding
MGAS9429_RS03045	COG0038	chloride channel
MGAS9429_RS03130	COG1131	(ABC) transporter
MGAS9429_RS03150	COG4708	membrane
MGAS9429_RS03160	COG1597	lipid kinase activity
MGAS9429_RS03245	COG0577	efflux transmembrane transporter activity
MGAS9429_RS03255	COG2321	neutral zinc metallopeptidase
MGAS9429_RS03270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_RS03280	COG1970	mechanosensitive ion channel activity
MGAS9429_RS03285	COG0358	DNA primase activity
MGAS9429_RS03290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MGAS9429_RS03295	COG2151	metal-sulfur cluster biosynthetic enzyme
MGAS9429_RS03340	COG1216	Glycosyl transferase, family 2
MGAS9429_RS03395	COG1368	sulfuric ester hydrolase activity
MGAS9429_RS03400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MGAS9429_RS03420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MGAS9429_RS03425	COG0285	dihydrofolate synthase activity
MGAS9429_RS03435	COG1104	cysteine desulfurase activity
MGAS9429_RS03460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGAS9429_RS03465	COG0583	DNA-binding transcription factor activity
MGAS9429_RS03475	COG0564	pseudouridine synthase activity
MGAS9429_RS03505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MGAS9429_RS03510	COG1136	(ABC) transporter
MGAS9429_RS03515	COG0577	efflux transmembrane transporter activity
MGAS9429_RS03520	COG0584	glycerophosphoryl diester phosphodiesterase
MGAS9429_RS03530	COG1837	Belongs to the UPF0109 family
MGAS9429_RS03580	COG1349	DNA-binding transcription factor activity
MGAS9429_RS03585	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS9429_RS03590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS9429_RS03590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MGAS9429_RS03590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS9429_RS03595	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_RS03595	COG1388	LysM domain
MGAS9429_RS03600	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_RS03600	COG1388	LysM domain
MGAS9429_RS03605	COG2801	Transposase and inactivated derivatives
MGAS9429_RS03620	COG0105	UTP biosynthetic process
MGAS9429_RS03640	COG0488	(ABC) transporter
MGAS9429_RS03650	COG0242	peptide deformylase activity
MGAS9429_RS03655	COG0737	Belongs to the 5'-nucleotidase family
MGAS9429_RS03660	COG2357	RelA SpoT domain protein
MGAS9429_RS03665	COG0745	RESPONSE REGULATOR receiver
MGAS9429_RS03705	COG3425	synthase
MGAS9429_RS03715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MGAS9429_RS03775	COG0583	DNA-binding transcription factor activity
MGAS9429_RS03800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_RS03805	COG0765	amino acid transport
MGAS9429_RS03825	COG0187	DNA topoisomerase II activity
MGAS9429_RS03835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MGAS9429_RS03855	COG0539	negative regulation of cytoplasmic translation
MGAS9429_RS03880	COG5433	transposase activity
MGAS9429_RS03895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MGAS9429_RS03900	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MGAS9429_RS03910	COG0300	oxidoreductase activity
MGAS9429_RS03930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MGAS9429_RS03935	COG2384	SAM-dependent methyltransferase
MGAS9429_RS03945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MGAS9429_RS03950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MGAS9429_RS03960	COG1088	dTDP-glucose 4,6-dehydratase activity
MGAS9429_RS03965	COG0582	viral genome integration into host DNA
MGAS9429_RS03985	COG3561	AntA/AntB antirepressor
MGAS9429_RS04225	COG1051	belongs to the nudix hydrolase family
MGAS9429_RS04230	COG0628	permease
MGAS9429_RS04235	COG0457	Tetratricopeptide repeat
MGAS9429_RS04240	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MGAS9429_RS04255	COG1129	ABC transporter
MGAS9429_RS04275	COG0488	(ABC) transporter
MGAS9429_RS04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MGAS9429_RS04285	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS9429_RS04285	COG0022	dehydrogenase e1 component
MGAS9429_RS04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGAS9429_RS04305	COG5492	domain, Protein
MGAS9429_RS04310	COG0095	Lipoate-protein ligase
MGAS9429_RS04315	COG3442	glutamine amidotransferase
MGAS9429_RS04320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS9429_RS04325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MGAS9429_RS04345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MGAS9429_RS04355	COG0647	UMP catabolic process
MGAS9429_RS04370	COG1518	maintenance of DNA repeat elements
MGAS9429_RS04375	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS9429_RS04390	COG0105	UTP biosynthetic process
MGAS9429_RS04435	COG3715	PTS system
MGAS9429_RS04440	COG3716	PTS system mannose fructose sorbose family IID component
MGAS9429_RS04445	COG2972	Histidine kinase
MGAS9429_RS04450	COG2207	Transcriptional regulator
MGAS9429_RS04450	COG4753	response regulator
MGAS9429_RS04460	COG1012	belongs to the aldehyde dehydrogenase family
MGAS9429_RS04475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS9429_RS04555	COG1131	(ABC) transporter
MGAS9429_RS04570	COG1396	sequence-specific DNA binding
MGAS9429_RS04605	COG0285	dihydrofolate synthase activity
MGAS9429_RS04625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MGAS9429_RS04640	COG1176	ABC-type spermidine putrescine transport system, permease component I
MGAS9429_RS04645	COG1177	transmembrane transport
MGAS9429_RS04655	COG4565	transcriptional regulatory protein
MGAS9429_RS04660	COG3290	protein histidine kinase activity
MGAS9429_RS04665	COG3493	citrate carrier protein
MGAS9429_RS04680	COG3700	Belongs to the class B bacterial acid phosphatase family
MGAS9429_RS04685	COG0038	chloride channel
MGAS9429_RS04695	COG0628	permease
MGAS9429_RS04705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MGAS9429_RS04720	COG1104	cysteine desulfurase activity
MGAS9429_RS04735	COG2357	RelA SpoT domain protein
MGAS9429_RS04745	COG0564	pseudouridine synthase activity
MGAS9429_RS04750	COG0280	phosphate acetyltransferase
MGAS9429_RS04755	COG4221	oxidoreductase activity
MGAS9429_RS04770	COG1174	glycine betaine transport
MGAS9429_RS04785	COG2233	PERMEase
MGAS9429_RS04810	COG2890	protein-(glutamine-N5) methyltransferase activity
MGAS9429_RS04840	COG1132	(ABC) transporter
MGAS9429_RS04845	COG1132	(ABC) transporter
MGAS9429_RS04865	COG3764	Sortase (surface protein transpeptidase)
MGAS9429_RS04870	COG0346	lactoylglutathione lyase activity
MGAS9429_RS04885	COG1272	protein, Hemolysin III
MGAS9429_RS04905	COG0758	DNA mediated transformation
MGAS9429_RS04910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MGAS9429_RS04950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MGAS9429_RS04970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MGAS9429_RS04980	COG2188	Transcriptional regulator
MGAS9429_RS05000	COG0488	(ABC) transporter
MGAS9429_RS05010	COG0352	thiamine-phosphate diphosphorylase activity
MGAS9429_RS05010	COG0351	phosphomethylpyrimidine kinase
MGAS9429_RS05015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MGAS9429_RS05020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MGAS9429_RS05020	COG1328	CTP reductase activity
MGAS9429_RS05025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MGAS9429_RS05055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MGAS9429_RS05065	COG0095	Lipoate-protein ligase
MGAS9429_RS05075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MGAS9429_RS05080	COG4684	Psort location CytoplasmicMembrane, score
MGAS9429_RS05085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS9429_RS05090	COG1079	Belongs to the binding-protein-dependent transport system permease family
MGAS9429_RS05095	COG4603	Belongs to the binding-protein-dependent transport system permease family
MGAS9429_RS05100	COG3845	ABC transporter
MGAS9429_RS05105	COG1744	ABC transporter substrate-binding protein PnrA-like
MGAS9429_RS05110	COG0295	cytidine deaminase activity
MGAS9429_RS05115	COG2813	Specifically methylates the guanine in position
MGAS9429_RS05130	COG5002	protein histidine kinase activity
MGAS9429_RS05135	COG0745	RESPONSE REGULATOR receiver
MGAS9429_RS05145	COG0704	Plays a role in the regulation of phosphate uptake
MGAS9429_RS05160	COG0581	inorganic phosphate transmembrane transporter activity
MGAS9429_RS05165	COG0573	inorganic phosphate transmembrane transporter activity
MGAS9429_RS05175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MGAS9429_RS05175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS9429_RS05180	COG0483	inositol monophosphate 1-phosphatase activity
MGAS9429_RS05195	COG0196	riboflavin kinase activity
MGAS9429_RS05225	COG4591	ABC-type transport system involved in lipoprotein release permease component
MGAS9429_RS05225	COG1136	(ABC) transporter
MGAS9429_RS05275	COG1115	amino acid carrier protein
MGAS9429_RS05280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MGAS9429_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_RS05295	COG1126	abc transporter atp-binding protein
MGAS9429_RS05300	COG0765	amino acid transport
MGAS9429_RS05305	COG2824	Alkylphosphonate utilization operon protein PhnA
MGAS9429_RS05320	COG0469	pyruvate kinase activity
MGAS9429_RS05335	COG1725	Transcriptional regulator
MGAS9429_RS05340	COG1131	(ABC) transporter
MGAS9429_RS05360	COG0058	SHG alpha-glucan phosphorylase activity
MGAS9429_RS05365	COG1640	4-alpha-glucanotransferase
MGAS9429_RS05370	COG1609	Transcriptional regulator
MGAS9429_RS05375	COG2182	Extracellular solute-binding protein
MGAS9429_RS05380	COG1175	transmembrane transport
MGAS9429_RS05385	COG3833	ABC-type maltose transport systems, permease component
MGAS9429_RS05400	COG0657	acetylesterase activity
MGAS9429_RS05405	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MGAS9429_RS05415	COG1696	Membrane protein involved in D-alanine export
MGAS9429_RS05435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MGAS9429_RS05440	COG1126	abc transporter atp-binding protein
MGAS9429_RS05450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_RS05460	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS9429_RS05470	COG3711	transcriptional antiterminator
MGAS9429_RS05470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGAS9429_RS05480	COG2723	6-phospho-beta-galactosidase activity
MGAS9429_RS05505	COG2801	Transposase and inactivated derivatives
MGAS9429_RS05510	COG1187	pseudouridine synthase activity
MGAS9429_RS05520	COG2814	Major facilitator Superfamily
MGAS9429_RS05570	COG4109	DRTGG domain
MGAS9429_RS05600	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MGAS9429_RS05600	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MGAS9429_RS05605	COG5433	transposase activity
MGAS9429_RS05610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MGAS9429_RS05615	COG1956	GAF domain-containing protein
MGAS9429_RS05635	COG0513	Belongs to the DEAD box helicase family
MGAS9429_RS05640	COG0726	polysaccharide deacetylase
MGAS9429_RS05660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MGAS9429_RS05665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS9429_RS05670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MGAS9429_RS05685	COG2801	Transposase and inactivated derivatives
MGAS9429_RS05690	COG2801	Transposase and inactivated derivatives
MGAS9429_RS05705	COG1476	TRANSCRIPTIONal
MGAS9429_RS05720	COG4122	O-methyltransferase activity
MGAS9429_RS05725	COG2223	nitrite transmembrane transporter activity
MGAS9429_RS05740	COG1187	pseudouridine synthase activity
MGAS9429_RS05785	COG2333	competence protein COMEC
MGAS9429_RS05785	COG0658	competence protein
MGAS9429_RS05790	COG1596	polysaccharide export
MGAS9429_RS05790	COG1555	photosystem II stabilization
MGAS9429_RS05795	COG0204	Acyl-transferase
MGAS9429_RS05800	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MGAS9429_RS05815	COG0513	Belongs to the DEAD box helicase family
MGAS9429_RS05830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MGAS9429_RS05845	COG2116	formate transmembrane transporter activity
MGAS9429_RS05855	COG1827	regulation of RNA biosynthetic process
MGAS9429_RS05870	COG2217	Heavy metal translocating P-type atpase
MGAS9429_RS05885	COG2755	lipolytic protein G-D-S-L family
MGAS9429_RS05900	COG0497	DNA recombination
MGAS9429_RS05905	COG1438	arginine binding
MGAS9429_RS05910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MGAS9429_RS05935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MGAS9429_RS05940	COG0415	Belongs to the DNA photolyase family
MGAS9429_RS05950	COG0765	amino acid transport
MGAS9429_RS05955	COG4703	Protein of unknown function (DUF1797)
MGAS9429_RS05960	COG0542	response to heat
MGAS9429_RS05965	COG0494	nUDIX hydrolase
MGAS9429_RS05980	COG3599	regulation of cell shape
MGAS9429_RS05985	COG2302	S4 RNA-binding domain
MGAS9429_RS06000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MGAS9429_RS06035	COG1217	gtp-binding protein TYPA
MGAS9429_RS06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MGAS9429_RS06045	COG1940	carbohydrate kinase activity
MGAS9429_RS06055	COG0783	Belongs to the Dps family
MGAS9429_RS06070	COG4470	Protein conserved in bacteria
MGAS9429_RS06075	COG1609	Transcriptional regulator
MGAS9429_RS06080	COG3480	Lon protease (S16) C-terminal proteolytic domain
MGAS9429_RS06090	COG0742	ribosomal rna small subunit methyltransferase
MGAS9429_RS06100	COG0549	Belongs to the carbamate kinase family
MGAS9429_RS06105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MGAS9429_RS06110	COG1288	antiporter activity
MGAS9429_RS06125	COG2235	arginine
MGAS9429_RS06150	COG2972	Histidine kinase
MGAS9429_RS06165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MGAS9429_RS06170	COG0785	Cytochrome C biogenesis protein
MGAS9429_RS06175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MGAS9429_RS06180	COG1518	maintenance of DNA repeat elements
MGAS9429_RS06240	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MGAS9429_RS06240	COG1605	Chorismate mutase
MGAS9429_RS06260	COG2226	methyltransferase
MGAS9429_RS06270	COG3250	beta-galactosidase activity
MGAS9429_RS06275	COG4753	response regulator
MGAS9429_RS06275	COG2207	Transcriptional regulator
MGAS9429_RS06280	COG2972	Histidine kinase
MGAS9429_RS06290	COG1653	transport
MGAS9429_RS06295	COG0395	ABC-type sugar transport system, permease component
MGAS9429_RS06300	COG1175	transmembrane transport
MGAS9429_RS06310	COG2723	6-phospho-beta-galactosidase activity
MGAS9429_RS06315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MGAS9429_RS06330	COG0383	alpha-mannosidase activity
MGAS9429_RS06425	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MGAS9429_RS06430	COG1739	Uncharacterized protein family UPF0029
MGAS9429_RS06440	COG1098	S1 RNA binding domain
MGAS9429_RS06450	COG2197	response regulator
MGAS9429_RS06455	COG4585	Histidine kinase
MGAS9429_RS06465	COG2815	serine threonine protein kinase
MGAS9429_RS06465	COG0515	serine threonine protein kinase
MGAS9429_RS06475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MGAS9429_RS06475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MGAS9429_RS06485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MGAS9429_RS06505	COG0583	DNA-binding transcription factor activity
MGAS9429_RS06510	COG0183	Belongs to the thiolase family
MGAS9429_RS06515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MGAS9429_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_RS06545	COG0116	Belongs to the methyltransferase superfamily
MGAS9429_RS06565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS9429_RS06570	COG3579	cysteine-type endopeptidase activity
MGAS9429_RS06580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MGAS9429_RS06585	COG1113	amino acid transport
MGAS9429_RS06590	COG0492	ferredoxin-NADP+ reductase activity
MGAS9429_RS06600	COG1126	abc transporter atp-binding protein
MGAS9429_RS06610	COG0513	Belongs to the DEAD box helicase family
MGAS9429_RS06620	COG0768	penicillin binding
MGAS9429_RS06655	COG1131	(ABC) transporter
MGAS9429_RS06680	COG0446	pyridine nucleotide-disulphide oxidoreductase
MGAS9429_RS06685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS9429_RS06720	COG1755	Isoprenylcysteine carboxyl methyltransferase
MGAS9429_RS06725	COG0656	L-ascorbic acid biosynthetic process
MGAS9429_RS06735	COG1283	sodium-dependent phosphate transmembrane transporter activity
MGAS9429_RS06755	COG0561	phosphatase activity
MGAS9429_RS06760	COG2860	membrane
MGAS9429_RS06770	COG1105	Belongs to the carbohydrate kinase PfkB family
MGAS9429_RS06810	COG2217	Heavy metal translocating P-type atpase
MGAS9429_RS06840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGAS9429_RS06845	COG0195	Participates in both transcription termination and antitermination
MGAS9429_RS06865	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_RS06985	COG1783	phage Terminase large subunit
MGAS9429_RS07100	COG4974	Belongs to the 'phage' integrase family
MGAS9429_RS07120	COG4473	ABC transporter
MGAS9429_RS07125	COG1131	(ABC) transporter
MGAS9429_RS07130	COG0537	adenosine 5'-monophosphoramidase activity
MGAS9429_RS07140	COG1316	TRANSCRIPTIONal
MGAS9429_RS07150	COG0802	atpase or kinase
MGAS9429_RS07155	COG2252	PERMEase
MGAS9429_RS07160	COG0561	phosphatase activity
MGAS9429_RS07170	COG3715	PTS system
MGAS9429_RS07175	COG3716	PTS system mannose fructose sorbose family IID component
MGAS9429_RS07200	COG0439	Biotin carboxylase
MGAS9429_RS07215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MGAS9429_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
MGAS9429_RS07225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MGAS9429_RS07250	COG1024	Enoyl-CoA hydratase
MGAS9429_RS07255	COG0484	heat shock protein binding
MGAS9429_RS07285	COG0588	phosphoglycerate mutase activity
MGAS9429_RS07290	COG2261	transglycosylase associated protein
MGAS9429_RS07315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MGAS9429_RS07315	COG0574	Belongs to the PEP-utilizing enzyme family
MGAS9429_RS07320	COG1335	isochorismatase
MGAS9429_RS07330	COG0436	Aminotransferase
MGAS9429_RS07340	COG0561	phosphatase activity
MGAS9429_RS07345	COG0252	asparaginase activity
MGAS9429_RS07360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MGAS9429_RS07365	COG1129	ABC transporter
MGAS9429_RS07380	COG1132	(ABC) transporter
MGAS9429_RS07385	COG4988	ABC transporter
MGAS9429_RS07415	COG3942	CHAP domain
MGAS9429_RS07415	COG1388	LysM domain
MGAS9429_RS07445	COG1482	cell wall glycoprotein biosynthetic process
MGAS9429_RS07450	COG1940	carbohydrate kinase activity
MGAS9429_RS07460	COG2190	(PTS) system
MGAS9429_RS07460	COG1263	PTS System
MGAS9429_RS07460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_RS07465	COG1621	beta-fructofuranosidase activity
MGAS9429_RS07470	COG1609	Transcriptional regulator
MGAS9429_RS07490	COG2131	deaminase
MGAS9429_RS07495	COG0006	proline dipeptidase activity
MGAS9429_RS07535	COG1194	a g-specific adenine glycosylase
MGAS9429_RS07545	COG3118	belongs to the thioredoxin family
MGAS9429_RS07575	COG0681	Belongs to the peptidase S26 family
MGAS9429_RS07580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MGAS9429_RS07595	COG1882	Formate acetyltransferase
MGAS9429_RS07600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MGAS9429_RS07615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MGAS9429_RS07620	COG2814	Major facilitator Superfamily
MGAS9429_RS07625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MGAS9429_RS07665	COG2081	HI0933 family
MGAS9429_RS07675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MGAS9429_RS07680	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MGAS9429_RS07700	COG0456	acetyltransferase
MGAS9429_RS07705	COG1214	PFAM Peptidase M22, glycoprotease
MGAS9429_RS07720	COG0174	glutamine synthetase
MGAS9429_RS07725	COG0789	Transcriptional regulator
MGAS9429_RS07740	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MGAS9429_RS07795	COG0668	transmembrane transport
MGAS9429_RS07805	COG4720	Psort location CytoplasmicMembrane, score
MGAS9429_RS07810	COG0351	phosphomethylpyrimidine kinase
MGAS9429_RS07855	COG1929	Belongs to the glycerate kinase type-1 family
MGAS9429_RS07860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MGAS9429_RS07890	COG0577	efflux transmembrane transporter activity
MGAS9429_RS07895	COG1136	(ABC) transporter
MGAS9429_RS07900	COG1132	(ABC) transporter
MGAS9429_RS07920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_RS07920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_RS07925	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS9429_RS07975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MGAS9429_RS08000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MGAS9429_RS08010	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MGAS9429_RS08025	COG1045	serine acetyltransferase
MGAS9429_RS08040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MGAS9429_RS08055	COG3711	transcriptional antiterminator
MGAS9429_RS08085	COG1846	Transcriptional regulator
MGAS9429_RS08105	COG4589	Belongs to the CDS family
MGAS9429_RS08115	COG1862	Preprotein translocase
MGAS9429_RS08125	COG1523	belongs to the glycosyl hydrolase 13 family
MGAS9429_RS08140	COG3842	ATPase activity
MGAS9429_RS08180	COG1263	PTS System
MGAS9429_RS08180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_RS08180	COG2190	(PTS) system
MGAS9429_RS08185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MGAS9429_RS08210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MGAS9429_RS08215	COG0512	Glutamine amidotransferase of anthranilate synthase
MGAS9429_RS08220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MGAS9429_RS08255	COG0601	transmembrane transport
MGAS9429_RS08285	COG0803	Belongs to the bacterial solute-binding protein 9 family
MGAS9429_RS08295	COG5433	transposase activity
MGAS9429_RS08300	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MGAS9429_RS08300	COG1404	Belongs to the peptidase S8 family
MGAS9429_RS08320	COG1196	nuclear chromosome segregation
MGAS9429_RS08325	COG3711	transcriptional antiterminator
MGAS9429_RS08335	COG1705	Flagellar rod assembly protein muramidase FlgJ
MGAS9429_RS08335	COG3942	CHAP domain
MGAS9429_RS08340	COG2205	protein histidine kinase activity
MGAS9429_RS08345	COG0745	RESPONSE REGULATOR receiver
MGAS9429_RS08350	COG0577	efflux transmembrane transporter activity
MGAS9429_RS08355	COG1136	(ABC) transporter
MGAS9429_RS08420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MGAS9429_RS08440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_RS08445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MGAS9429_RS08450	COG1447	Phosphotransferase system cellobiose-specific component IIA
MGAS9429_RS08455	COG2390	Transcriptional regulator
MGAS9429_RS08460	COG1349	DNA-binding transcription factor activity
MGAS9429_RS08465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MGAS9429_RS08480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MGAS9429_RS08495	COG0564	pseudouridine synthase activity
MGAS9429_RS08525	COG0542	response to heat
MGAS9429_RS08530	COG4463	regulation of RNA biosynthetic process
MGAS9429_RS08545	COG0450	alkyl hydroperoxide reductase
MGAS9429_RS08560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MGAS9429_RS08570	COG3404	Formiminotransferase-cyclodeaminase
MGAS9429_RS08585	COG0531	amino acid
MGAS9429_RS08615	COG3590	peptidase
MGAS9429_RS08620	COG0366	Alpha amylase catalytic
MGAS9429_RS08625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MGAS9429_RS08625	COG1263	PTS System
MGAS9429_RS08630	COG2188	Transcriptional regulator
MGAS9429_RS08635	COG1733	regulation of RNA biosynthetic process
MGAS9429_RS08640	COG2514	catechol 2,3-dioxygenase activity
MGAS9429_RS08650	COG0602	queuosine metabolic process
MGAS9429_RS08660	COG0673	inositol 2-dehydrogenase activity
MGAS9429_RS08665	COG1328	CTP reductase activity
MGAS9429_RS08690	COG1393	Belongs to the ArsC family
MGAS9429_RS08705	COG0519	Catalyzes the synthesis of GMP from XMP
MGAS9429_RS08715	COG2814	Major facilitator Superfamily
MGAS9429_RS08745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_RS08750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_RS08755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_RS08775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MGAS9429_RS08835	COG1511	domain protein
MGAS9429_RS08855	COG0305	Participates in initiation and elongation during chromosome replication
MGAS9429_RS08885	COG1760	l-serine dehydratase
MGAS9429_RS08890	COG1760	l-serine dehydratase
MGAS9429_RS08895	COG0741	lytic transglycosylase activity
MGAS9429_RS08900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MGAS9429_RS08915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MGAS9429_RS08925	COG0612	Peptidase, M16
MGAS9429_RS08935	COG1215	transferase activity, transferring glycosyl groups
MGAS9429_RS08965	COG0516	GMP reductase activity
MGAS9429_RS08965	COG0517	IMP dehydrogenase activity
MGAS9429_RS08975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MGAS9429_RS08980	COG0488	(ABC) transporter
MGAS9429_RS09020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MGAS9429_RS09025	COG1475	DNA binding