locus-tag	class	description
MTB313_RS00010	COG0592	DNA-directed DNA polymerase activity
MTB313_RS00020	COG0012	GTP binding
MTB313_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MTB313_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTB313_RS00245	COG3942	CHAP domain
MTB313_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTB313_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTB313_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MTB313_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MTB313_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MTB313_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTB313_RS00360	COG1064	alcohol dehydrogenase
MTB313_RS00365	COG0534	Mate efflux family protein
MTB313_RS00475	COG0201	protein transport
MTB313_RS00620	COG1121	(ABC) transporter
MTB313_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MTB313_RS00660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MTB313_RS00665	COG1459	type II secretion system
MTB313_RS00670	COG4537	Required for transformation and DNA binding
MTB313_RS00710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MTB313_RS00715	COG1363	Peptidase, m42
MTB313_RS00735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTB313_RS00745	COG1428	Deoxynucleoside kinase
MTB313_RS00750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MTB313_RS00785	COG4509	Sortase family
MTB313_RS00795	COG4372	Transposase
MTB313_RS00825	COG2031	fatty acid transporter
MTB313_RS00840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MTB313_RS00855	COG0251	oxidation-reduction process
MTB313_RS00870	COG1269	ATP hydrolysis coupled proton transport
MTB313_RS00875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTB313_RS00885	COG1527	subunit (C
MTB313_RS00890	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MTB313_RS00925	COG1744	ABC transporter substrate-binding protein PnrA-like
MTB313_RS00970	COG0626	cystathionine gamma-synthase activity
MTB313_RS01000	COG3623	hexulose-6-phosphate isomerase
MTB313_RS01025	COG3448	diguanylate cyclase activity
MTB313_RS01025	COG4175	Glycine betaine
MTB313_RS01035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTB313_RS01035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MTB313_RS01060	COG1475	DNA binding
MTB313_RS01085	COG0157	Belongs to the NadC ModD family
MTB313_RS01110	COG1268	BioY protein
MTB313_RS01115	COG1234	tRNA 3'-trailer cleavage
MTB313_RS01160	COG0457	Tetratricopeptide repeat
MTB313_RS01160	COG0705	Rhomboid family
MTB313_RS01180	COG1132	(ABC) transporter
MTB313_RS01185	COG1132	(ABC) transporter
MTB313_RS01195	COG0756	dUTP diphosphatase activity
MTB313_RS01245	COG1847	R3H domain protein
MTB313_RS01265	COG1175	transmembrane transport
MTB313_RS01270	COG0395	ABC-type sugar transport system, permease component
MTB313_RS01280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTB313_RS01295	COG0084	hydrolase, TatD family'
MTB313_RS01320	COG1564	THIamine pyrophosphokinase
MTB313_RS01335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MTB313_RS01375	COG0765	amino acid transport
MTB313_RS01395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTB313_RS01405	COG0719	Fe-S assembly protein
MTB313_RS01410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MTB313_RS01425	COG1686	Belongs to the peptidase S11 family
MTB313_RS01430	COG1686	Belongs to the peptidase S11 family
MTB313_RS01435	COG4166	transmembrane transport
MTB313_RS01440	COG0601	transmembrane transport
MTB313_RS01445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTB313_RS01450	COG0444	Belongs to the ABC transporter superfamily
MTB313_RS01460	COG2801	Transposase and inactivated derivatives
MTB313_RS01510	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MTB313_RS01515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MTB313_RS01520	COG1534	Rna-binding protein
MTB313_RS01530	COG1713	HD superfamily hydrolase involved in NAD metabolism
MTB313_RS01535	COG0799	negative regulation of ribosome biogenesis
MTB313_RS01540	COG2226	methyltransferase
MTB313_RS01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTB313_RS01580	COG1114	Component of the transport system for branched-chain amino acids
MTB313_RS01590	COG0569	domain protein
MTB313_RS01595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MTB313_RS01605	COG1704	LemA family
MTB313_RS01620	COG0745	RESPONSE REGULATOR receiver
MTB313_RS01640	COG1484	DNA-dependent DNA replication
MTB313_RS01670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MTB313_RS01685	COG1254	Belongs to the acylphosphatase family
MTB313_RS01700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTB313_RS01755	COG1187	pseudouridine synthase activity
MTB313_RS01770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MTB313_RS01775	COG0671	phosphoesterase, PA-phosphatase related
MTB313_RS01780	COG1242	4 iron, 4 sulfur cluster binding
MTB313_RS01785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MTB313_RS01795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTB313_RS01810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTB313_RS01815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTB313_RS01820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTB313_RS01825	COG1120	ATPase activity
MTB313_RS01835	COG2244	polysaccharide biosynthetic process
MTB313_RS01870	COG0470	DNA polymerase III
MTB313_RS01900	COG1393	Belongs to the ArsC family
MTB313_RS01905	COG0708	Exodeoxyribonuclease III
MTB313_RS01915	COG1304	FMN binding
MTB313_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
MTB313_RS02010	COG0673	inositol 2-dehydrogenase activity
MTB313_RS02025	COG0494	nUDIX hydrolase
MTB313_RS02035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MTB313_RS02125	COG1702	phosphate starvation-inducible protein PhoH
MTB313_RS02130	COG1573	uracil-dna glycosylase
MTB313_RS02140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MTB313_RS02235	COG0433	COG0433 Predicted ATPase
MTB313_RS02240	COG2814	Major facilitator Superfamily
MTB313_RS02285	COG0463	Glycosyl transferase, family 2
MTB313_RS02295	COG0778	Nitroreductase
MTB313_RS02300	COG0006	proline dipeptidase activity
MTB313_RS02305	COG1609	Transcriptional regulator
MTB313_RS02315	COG0438	transferase activity, transferring glycosyl groups
MTB313_RS02325	COG4555	ABC transporter
MTB313_RS02345	COG0183	Belongs to the thiolase family
MTB313_RS02360	COG0745	RESPONSE REGULATOR receiver
MTB313_RS02365	COG5002	protein histidine kinase activity
MTB313_RS02370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MTB313_RS02380	COG1196	nuclear chromosome segregation
MTB313_RS02395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MTB313_RS02480	COG4695	Portal protein
MTB313_RS02525	COG0561	phosphatase activity
MTB313_RS02535	COG0552	protein localization to endoplasmic reticulum
MTB313_RS02540	COG0477	Major facilitator Superfamily
MTB313_RS02545	COG3711	transcriptional antiterminator
MTB313_RS02550	COG1263	PTS System
MTB313_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTB313_RS02550	COG2190	(PTS) system
MTB313_RS02560	COG3689	TIGRFAM TIGR03943 family protein
MTB313_RS02565	COG0701	Predicted permease
MTB313_RS02575	COG2183	response to ionizing radiation
MTB313_RS02620	COG0826	peptidase U32
MTB313_RS02625	COG4443	Transcriptional Coactivator p15 (PC4)
MTB313_RS02670	COG0386	Belongs to the glutathione peroxidase family
MTB313_RS02675	COG1164	Oligoendopeptidase f
MTB313_RS02685	COG0772	Belongs to the SEDS family
MTB313_RS02720	COG1078	dGTPase activity
MTB313_RS02745	COG3716	PTS system mannose fructose sorbose family IID component
MTB313_RS02750	COG3715	PTS system
MTB313_RS02755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTB313_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
MTB313_RS02790	COG0800	Aldolase
MTB313_RS02795	COG0546	phosphoglycolate phosphatase activity
MTB313_RS02810	COG2884	Cell division ATP-binding protein ftsE
MTB313_RS02815	COG2177	Part of the ABC transporter FtsEX involved in
MTB313_RS02835	COG1199	ATP-dependent helicase activity
MTB313_RS02835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MTB313_RS02840	COG0436	Aminotransferase
MTB313_RS02875	COG2188	Transcriptional regulator
MTB313_RS02880	COG2222	sugar isomerase
MTB313_RS02890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MTB313_RS02895	COG0716	FMN binding
MTB313_RS02905	COG0038	chloride channel
MTB313_RS03000	COG1131	(ABC) transporter
MTB313_RS03025	COG4708	membrane
MTB313_RS03035	COG1597	lipid kinase activity
MTB313_RS03120	COG0577	efflux transmembrane transporter activity
MTB313_RS03125	COG1136	(ABC) transporter
MTB313_RS03130	COG2321	neutral zinc metallopeptidase
MTB313_RS03145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTB313_RS03155	COG1970	mechanosensitive ion channel activity
MTB313_RS03165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MTB313_RS03170	COG2151	metal-sulfur cluster biosynthetic enzyme
MTB313_RS03280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MTB313_RS03300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MTB313_RS03305	COG0285	dihydrofolate synthase activity
MTB313_RS03315	COG1104	cysteine desulfurase activity
MTB313_RS03340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MTB313_RS03345	COG0583	DNA-binding transcription factor activity
MTB313_RS03355	COG0564	pseudouridine synthase activity
MTB313_RS03385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MTB313_RS03390	COG1136	(ABC) transporter
MTB313_RS03395	COG0577	efflux transmembrane transporter activity
MTB313_RS03410	COG1837	Belongs to the UPF0109 family
MTB313_RS03465	COG1105	Belongs to the carbohydrate kinase PfkB family
MTB313_RS03470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTB313_RS03470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTB313_RS03470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MTB313_RS03475	COG1388	LysM domain
MTB313_RS03475	COG1705	Flagellar rod assembly protein muramidase FlgJ
MTB313_RS03480	COG1705	Flagellar rod assembly protein muramidase FlgJ
MTB313_RS03480	COG1388	LysM domain
MTB313_RS03505	COG0105	UTP biosynthetic process
MTB313_RS03525	COG0488	(ABC) transporter
MTB313_RS03535	COG0242	peptide deformylase activity
MTB313_RS03545	COG2357	RelA SpoT domain protein
MTB313_RS03550	COG0745	RESPONSE REGULATOR receiver
MTB313_RS03585	COG3425	synthase
MTB313_RS03595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MTB313_RS03655	COG0583	DNA-binding transcription factor activity
MTB313_RS03680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTB313_RS03685	COG0765	amino acid transport
MTB313_RS03705	COG0187	DNA topoisomerase II activity
MTB313_RS03715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTB313_RS03735	COG0539	negative regulation of cytoplasmic translation
MTB313_RS03780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MTB313_RS03785	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MTB313_RS03795	COG0300	oxidoreductase activity
MTB313_RS03815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MTB313_RS03820	COG2384	SAM-dependent methyltransferase
MTB313_RS03830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MTB313_RS03835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MTB313_RS03845	COG1088	dTDP-glucose 4,6-dehydratase activity
MTB313_RS03850	COG1051	belongs to the nudix hydrolase family
MTB313_RS03855	COG0628	permease
MTB313_RS03860	COG0457	Tetratricopeptide repeat
MTB313_RS03865	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MTB313_RS03885	COG1129	ABC transporter
MTB313_RS03905	COG0488	(ABC) transporter
MTB313_RS03910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MTB313_RS03915	COG0022	dehydrogenase e1 component
MTB313_RS03915	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTB313_RS03950	COG0095	Lipoate-protein ligase
MTB313_RS03955	COG3442	glutamine amidotransferase
MTB313_RS03960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MTB313_RS03965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MTB313_RS03985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MTB313_RS04000	COG0647	UMP catabolic process
MTB313_RS04020	COG1518	maintenance of DNA repeat elements
MTB313_RS04025	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MTB313_RS04040	COG0105	UTP biosynthetic process
MTB313_RS04075	COG3715	PTS system
MTB313_RS04080	COG3716	PTS system mannose fructose sorbose family IID component
MTB313_RS04085	COG2972	Histidine kinase
MTB313_RS04090	COG2207	Transcriptional regulator
MTB313_RS04090	COG4753	response regulator
MTB313_RS04095	COG1840	ABC-type Fe3 transport system, periplasmic component
MTB313_RS04110	COG1011	Hydrolase
MTB313_RS04115	COG1012	belongs to the aldehyde dehydrogenase family
MTB313_RS04130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTB313_RS04195	COG1131	(ABC) transporter
MTB313_RS04210	COG1396	sequence-specific DNA binding
MTB313_RS04240	COG0285	dihydrofolate synthase activity
MTB313_RS04260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MTB313_RS04275	COG1176	ABC-type spermidine putrescine transport system, permease component I
MTB313_RS04280	COG1177	transmembrane transport
MTB313_RS04290	COG4565	transcriptional regulatory protein
MTB313_RS04295	COG3290	protein histidine kinase activity
MTB313_RS04300	COG3493	citrate carrier protein
MTB313_RS04315	COG3700	Belongs to the class B bacterial acid phosphatase family
MTB313_RS04340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MTB313_RS04355	COG1104	cysteine desulfurase activity
MTB313_RS04370	COG2357	RelA SpoT domain protein
MTB313_RS04380	COG0564	pseudouridine synthase activity
MTB313_RS04385	COG0280	phosphate acetyltransferase
MTB313_RS04405	COG1174	glycine betaine transport
MTB313_RS04425	COG2233	PERMEase
MTB313_RS04450	COG2890	protein-(glutamine-N5) methyltransferase activity
MTB313_RS04480	COG1132	(ABC) transporter
MTB313_RS04485	COG1132	(ABC) transporter
MTB313_RS04505	COG3764	Sortase (surface protein transpeptidase)
MTB313_RS04510	COG0346	lactoylglutathione lyase activity
MTB313_RS04530	COG1272	protein, Hemolysin III
MTB313_RS04550	COG0758	DNA mediated transformation
MTB313_RS04605	COG0511	ligase activity, forming carbon-carbon bonds
MTB313_RS04610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MTB313_RS04625	COG2851	Citrate transporter
MTB313_RS04635	COG0511	ligase activity, forming carbon-carbon bonds
MTB313_RS04640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MTB313_RS04670	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MTB313_RS04700	COG2188	Transcriptional regulator
MTB313_RS04720	COG0488	(ABC) transporter
MTB313_RS04730	COG0351	phosphomethylpyrimidine kinase
MTB313_RS04730	COG0352	thiamine-phosphate diphosphorylase activity
MTB313_RS04745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MTB313_RS04745	COG1328	CTP reductase activity
MTB313_RS04750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MTB313_RS04780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTB313_RS04800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MTB313_RS04805	COG4684	Psort location CytoplasmicMembrane, score
MTB313_RS04810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTB313_RS04815	COG1079	Belongs to the binding-protein-dependent transport system permease family
MTB313_RS04820	COG4603	Belongs to the binding-protein-dependent transport system permease family
MTB313_RS04825	COG3845	ABC transporter
MTB313_RS04830	COG1744	ABC transporter substrate-binding protein PnrA-like
MTB313_RS04835	COG0295	cytidine deaminase activity
MTB313_RS04875	COG0704	Plays a role in the regulation of phosphate uptake
MTB313_RS04890	COG0581	inorganic phosphate transmembrane transporter activity
MTB313_RS04895	COG0573	inorganic phosphate transmembrane transporter activity
MTB313_RS04905	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MTB313_RS04905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MTB313_RS04910	COG0483	inositol monophosphate 1-phosphatase activity
MTB313_RS04925	COG0196	riboflavin kinase activity
MTB313_RS04955	COG4591	ABC-type transport system involved in lipoprotein release permease component
MTB313_RS04955	COG1136	(ABC) transporter
MTB313_RS05005	COG1115	amino acid carrier protein
MTB313_RS05010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MTB313_RS05020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTB313_RS05025	COG1126	abc transporter atp-binding protein
MTB313_RS05030	COG0765	amino acid transport
MTB313_RS05035	COG2824	Alkylphosphonate utilization operon protein PhnA
MTB313_RS05050	COG0469	pyruvate kinase activity
MTB313_RS05065	COG1725	Transcriptional regulator
MTB313_RS05130	COG1396	sequence-specific DNA binding
MTB313_RS05180	COG0058	SHG alpha-glucan phosphorylase activity
MTB313_RS05185	COG1640	4-alpha-glucanotransferase
MTB313_RS05195	COG2182	Extracellular solute-binding protein
MTB313_RS05200	COG1175	transmembrane transport
MTB313_RS05205	COG3833	ABC-type maltose transport systems, permease component
MTB313_RS05220	COG3833	ABC-type maltose transport systems, permease component
MTB313_RS05225	COG1175	transmembrane transport
MTB313_RS05235	COG0366	Alpha amylase catalytic
MTB313_RS05240	COG2182	Extracellular solute-binding protein
MTB313_RS05250	COG0657	acetylesterase activity
MTB313_RS05255	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MTB313_RS05265	COG1696	Membrane protein involved in D-alanine export
MTB313_RS05285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTB313_RS05290	COG1126	abc transporter atp-binding protein
MTB313_RS05295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MTB313_RS05305	COG1447	Phosphotransferase system cellobiose-specific component IIA
MTB313_RS05315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MTB313_RS05315	COG3711	transcriptional antiterminator
MTB313_RS05325	COG2723	6-phospho-beta-galactosidase activity
MTB313_RS05365	COG2814	Major facilitator Superfamily
MTB313_RS05415	COG4109	DRTGG domain
MTB313_RS05445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MTB313_RS05445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MTB313_RS05455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MTB313_RS05460	COG1956	GAF domain-containing protein
MTB313_RS05480	COG0513	Belongs to the DEAD box helicase family
MTB313_RS05505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MTB313_RS05510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTB313_RS05515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTB313_RS05545	COG1476	TRANSCRIPTIONal
MTB313_RS05560	COG4122	O-methyltransferase activity
MTB313_RS05565	COG2223	nitrite transmembrane transporter activity
MTB313_RS05580	COG1187	pseudouridine synthase activity
MTB313_RS05630	COG1555	photosystem II stabilization
MTB313_RS05630	COG1596	polysaccharide export
MTB313_RS05635	COG0204	Acyl-transferase
MTB313_RS05640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MTB313_RS05655	COG0513	Belongs to the DEAD box helicase family
MTB313_RS05675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MTB313_RS05690	COG0768	penicillin binding
MTB313_RS05695	COG2116	formate transmembrane transporter activity
MTB313_RS05705	COG1827	regulation of RNA biosynthetic process
MTB313_RS05720	COG2217	Heavy metal translocating P-type atpase
MTB313_RS05870	COG3935	DnaD domain protein
MTB313_RS05920	COG3561	AntA/AntB antirepressor
MTB313_RS05935	COG1396	sequence-specific DNA binding
MTB313_RS05950	COG0582	viral genome integration into host DNA
MTB313_RS05960	COG2755	lipolytic protein G-D-S-L family
MTB313_RS05975	COG0497	DNA recombination
MTB313_RS05980	COG1438	arginine binding
MTB313_RS05985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MTB313_RS06010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTB313_RS06025	COG0765	amino acid transport
MTB313_RS06030	COG4703	Protein of unknown function (DUF1797)
MTB313_RS06035	COG0542	response to heat
MTB313_RS06040	COG0494	nUDIX hydrolase
MTB313_RS06055	COG3599	regulation of cell shape
MTB313_RS06060	COG2302	S4 RNA-binding domain
MTB313_RS06075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MTB313_RS06110	COG1217	gtp-binding protein TYPA
MTB313_RS06115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MTB313_RS06120	COG1940	carbohydrate kinase activity
MTB313_RS06130	COG0783	Belongs to the Dps family
MTB313_RS06145	COG4470	Protein conserved in bacteria
MTB313_RS06155	COG3480	Lon protease (S16) C-terminal proteolytic domain
MTB313_RS06165	COG0742	ribosomal rna small subunit methyltransferase
MTB313_RS06175	COG0549	Belongs to the carbamate kinase family
MTB313_RS06180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTB313_RS06185	COG1288	antiporter activity
MTB313_RS06200	COG2235	arginine
MTB313_RS06225	COG2972	Histidine kinase
MTB313_RS06240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTB313_RS06245	COG0785	Cytochrome C biogenesis protein
MTB313_RS06250	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MTB313_RS06255	COG1518	maintenance of DNA repeat elements
MTB313_RS06320	COG1605	Chorismate mutase
MTB313_RS06320	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MTB313_RS06340	COG2226	methyltransferase
MTB313_RS06355	COG2207	Transcriptional regulator
MTB313_RS06355	COG4753	response regulator
MTB313_RS06360	COG2972	Histidine kinase
MTB313_RS06375	COG0395	ABC-type sugar transport system, permease component
MTB313_RS06380	COG1175	transmembrane transport
MTB313_RS06385	COG1940	carbohydrate kinase activity
MTB313_RS06390	COG2723	6-phospho-beta-galactosidase activity
MTB313_RS06395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MTB313_RS06410	COG0383	alpha-mannosidase activity
MTB313_RS06520	COG1739	Uncharacterized protein family UPF0029
MTB313_RS06530	COG1098	S1 RNA binding domain
MTB313_RS06540	COG2197	response regulator
MTB313_RS06565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MTB313_RS06565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MTB313_RS06575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MTB313_RS06600	COG0183	Belongs to the thiolase family
MTB313_RS06605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MTB313_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
MTB313_RS06620	COG2610	gluconate transmembrane transporter activity
MTB313_RS06635	COG0116	Belongs to the methyltransferase superfamily
MTB313_RS06660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTB313_RS06665	COG3579	cysteine-type endopeptidase activity
MTB313_RS06675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MTB313_RS06680	COG1113	amino acid transport
MTB313_RS06685	COG0492	ferredoxin-NADP+ reductase activity
MTB313_RS06695	COG1126	abc transporter atp-binding protein
MTB313_RS06715	COG0768	penicillin binding
MTB313_RS06755	COG1131	(ABC) transporter
MTB313_RS06780	COG0446	pyridine nucleotide-disulphide oxidoreductase
MTB313_RS06785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MTB313_RS06830	COG1755	Isoprenylcysteine carboxyl methyltransferase
MTB313_RS06835	COG0656	L-ascorbic acid biosynthetic process
MTB313_RS06845	COG1283	sodium-dependent phosphate transmembrane transporter activity
MTB313_RS06865	COG0561	phosphatase activity
MTB313_RS06870	COG2860	membrane
MTB313_RS06925	COG2217	Heavy metal translocating P-type atpase
MTB313_RS06955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MTB313_RS06960	COG0195	Participates in both transcription termination and antitermination
MTB313_RS06980	COG4473	ABC transporter
MTB313_RS06985	COG1131	(ABC) transporter
MTB313_RS06990	COG0537	adenosine 5'-monophosphoramidase activity
MTB313_RS07000	COG1316	TRANSCRIPTIONal
MTB313_RS07010	COG0802	atpase or kinase
MTB313_RS07015	COG2252	PERMEase
MTB313_RS07020	COG0561	phosphatase activity
MTB313_RS07030	COG3715	PTS system
MTB313_RS07035	COG3716	PTS system mannose fructose sorbose family IID component
MTB313_RS07060	COG0439	Biotin carboxylase
MTB313_RS07075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MTB313_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
MTB313_RS07085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MTB313_RS07110	COG1024	Enoyl-CoA hydratase
MTB313_RS07145	COG0588	phosphoglycerate mutase activity
MTB313_RS07150	COG2261	transglycosylase associated protein
MTB313_RS07185	COG1335	isochorismatase
MTB313_RS07205	COG0561	phosphatase activity
MTB313_RS07210	COG0252	asparaginase activity
MTB313_RS07225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MTB313_RS07235	COG1129	ABC transporter
MTB313_RS07255	COG4988	ABC transporter
MTB313_RS07260	COG1120	ATPase activity
MTB313_RS07285	COG1388	LysM domain
MTB313_RS07285	COG3942	CHAP domain
MTB313_RS07315	COG1482	cell wall glycoprotein biosynthetic process
MTB313_RS07320	COG1940	carbohydrate kinase activity
MTB313_RS07330	COG2190	(PTS) system
MTB313_RS07330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTB313_RS07330	COG1263	PTS System
MTB313_RS07335	COG1621	beta-fructofuranosidase activity
MTB313_RS07340	COG1609	Transcriptional regulator
MTB313_RS07360	COG2131	deaminase
MTB313_RS07365	COG0006	proline dipeptidase activity
MTB313_RS07405	COG1194	a g-specific adenine glycosylase
MTB313_RS07415	COG3118	belongs to the thioredoxin family
MTB313_RS07445	COG0681	Belongs to the peptidase S26 family
MTB313_RS07450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MTB313_RS07465	COG1882	Formate acetyltransferase
MTB313_RS07470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MTB313_RS07485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MTB313_RS07500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MTB313_RS07525	COG0789	Transcriptional regulator
MTB313_RS07540	COG2081	HI0933 family
MTB313_RS07550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MTB313_RS07555	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MTB313_RS07575	COG0456	acetyltransferase
MTB313_RS07580	COG1214	PFAM Peptidase M22, glycoprotease
MTB313_RS07595	COG0174	glutamine synthetase
MTB313_RS07600	COG0789	Transcriptional regulator
MTB313_RS07615	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MTB313_RS07690	COG4720	Psort location CytoplasmicMembrane, score
MTB313_RS07695	COG0351	phosphomethylpyrimidine kinase
MTB313_RS07740	COG1929	Belongs to the glycerate kinase type-1 family
MTB313_RS07765	COG2274	protein secretion by the type I secretion system
MTB313_RS07785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MTB313_RS07785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MTB313_RS07790	COG1447	Phosphotransferase system cellobiose-specific component IIA
MTB313_RS07850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MTB313_RS07855	COG1476	TRANSCRIPTIONal
MTB313_RS07875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTB313_RS07885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MTB313_RS07905	COG1045	serine acetyltransferase
MTB313_RS07920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTB313_RS07925	COG3037	sugar-specific permease SgaT UlaA
MTB313_RS07935	COG3711	transcriptional antiterminator
MTB313_RS07965	COG1846	Transcriptional regulator
MTB313_RS07985	COG4589	Belongs to the CDS family
MTB313_RS08005	COG1523	belongs to the glycosyl hydrolase 13 family
MTB313_RS08020	COG3842	ATPase activity
MTB313_RS08060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTB313_RS08060	COG1263	PTS System
MTB313_RS08060	COG2190	(PTS) system
MTB313_RS08065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MTB313_RS08080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MTB313_RS08085	COG0512	Glutamine amidotransferase of anthranilate synthase
MTB313_RS08130	COG0601	transmembrane transport
MTB313_RS08140	COG1122	ATPase activity
MTB313_RS08160	COG0803	Belongs to the bacterial solute-binding protein 9 family
MTB313_RS08220	COG0745	RESPONSE REGULATOR receiver
MTB313_RS08225	COG0577	efflux transmembrane transporter activity
MTB313_RS08230	COG1136	(ABC) transporter
MTB313_RS08295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MTB313_RS08310	COG1882	Formate acetyltransferase
MTB313_RS08315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MTB313_RS08320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MTB313_RS08325	COG1447	Phosphotransferase system cellobiose-specific component IIA
MTB313_RS08330	COG2390	Transcriptional regulator
MTB313_RS08335	COG1349	DNA-binding transcription factor activity
MTB313_RS08340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MTB313_RS08375	COG0564	pseudouridine synthase activity
MTB313_RS08410	COG0542	response to heat
MTB313_RS08415	COG4463	regulation of RNA biosynthetic process
MTB313_RS08430	COG0450	alkyl hydroperoxide reductase
MTB313_RS08445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MTB313_RS08455	COG3404	Formiminotransferase-cyclodeaminase
MTB313_RS08470	COG0531	amino acid
MTB313_RS08500	COG3590	peptidase
MTB313_RS08505	COG0366	Alpha amylase catalytic
MTB313_RS08510	COG1263	PTS System
MTB313_RS08510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTB313_RS08515	COG2188	Transcriptional regulator
MTB313_RS08525	COG1733	regulation of RNA biosynthetic process
MTB313_RS08530	COG2514	catechol 2,3-dioxygenase activity
MTB313_RS08540	COG0602	queuosine metabolic process
MTB313_RS08555	COG1328	CTP reductase activity
MTB313_RS08580	COG1393	Belongs to the ArsC family
MTB313_RS08595	COG0519	Catalyzes the synthesis of GMP from XMP
MTB313_RS08605	COG2814	Major facilitator Superfamily
MTB313_RS08640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MTB313_RS08645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MTB313_RS08650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MTB313_RS08735	COG1511	domain protein
MTB313_RS08755	COG5433	transposase activity
MTB313_RS08765	COG0305	Participates in initiation and elongation during chromosome replication
MTB313_RS08795	COG1760	l-serine dehydratase
MTB313_RS08800	COG1760	l-serine dehydratase
MTB313_RS08805	COG0741	lytic transglycosylase activity
MTB313_RS08810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MTB313_RS08825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MTB313_RS08875	COG0517	IMP dehydrogenase activity
MTB313_RS08875	COG0516	GMP reductase activity
MTB313_RS08885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MTB313_RS08890	COG0488	(ABC) transporter
MTB313_RS08935	COG1475	DNA binding