locus-tag	class	description
A4265_RS00045	COG3942	CHAP domain
A4265_RS00065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4265_RS00075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4265_RS00090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4265_RS00110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4265_RS00135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4265_RS00150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4265_RS00165	COG1012	belongs to the aldehyde dehydrogenase family
A4265_RS00165	COG1454	alcohol dehydrogenase
A4265_RS00170	COG1064	alcohol dehydrogenase
A4265_RS00175	COG0534	Mate efflux family protein
A4265_RS00285	COG0201	protein transport
A4265_RS00400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4265_RS00420	COG1121	(ABC) transporter
A4265_RS00425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4265_RS00435	COG0582	viral genome integration into host DNA
A4265_RS00535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4265_RS00555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4265_RS00560	COG1459	type II secretion system
A4265_RS00565	COG4537	Required for transformation and DNA binding
A4265_RS00600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4265_RS00605	COG1363	Peptidase, m42
A4265_RS00615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4265_RS00620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4265_RS00635	COG1428	Deoxynucleoside kinase
A4265_RS00640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4265_RS00670	COG4509	Sortase family
A4265_RS00695	COG2031	fatty acid transporter
A4265_RS00710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4265_RS00725	COG0251	oxidation-reduction process
A4265_RS00740	COG1269	ATP hydrolysis coupled proton transport
A4265_RS00745	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4265_RS00755	COG1527	subunit (C
A4265_RS00760	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A4265_RS00795	COG1744	ABC transporter substrate-binding protein PnrA-like
A4265_RS00840	COG0626	cystathionine gamma-synthase activity
A4265_RS00870	COG3623	hexulose-6-phosphate isomerase
A4265_RS00890	COG3448	diguanylate cyclase activity
A4265_RS00890	COG4175	Glycine betaine
A4265_RS00900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4265_RS00900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4265_RS00920	COG3969	phosphoadenosine phosphosulfate
A4265_RS00925	COG1475	DNA binding
A4265_RS00935	COG2801	Transposase and inactivated derivatives
A4265_RS00950	COG0157	Belongs to the NadC ModD family
A4265_RS00955	COG2801	Transposase and inactivated derivatives
A4265_RS00975	COG1268	BioY protein
A4265_RS00980	COG1234	tRNA 3'-trailer cleavage
A4265_RS01015	COG0457	Tetratricopeptide repeat
A4265_RS01015	COG0705	Rhomboid family
A4265_RS01035	COG1132	(ABC) transporter
A4265_RS01040	COG1132	(ABC) transporter
A4265_RS01050	COG0756	dUTP diphosphatase activity
A4265_RS01080	COG3290	protein histidine kinase activity
A4265_RS01105	COG1847	R3H domain protein
A4265_RS01125	COG1175	transmembrane transport
A4265_RS01130	COG0395	ABC-type sugar transport system, permease component
A4265_RS01140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4265_RS01155	COG0084	hydrolase, TatD family'
A4265_RS01180	COG1564	THIamine pyrophosphokinase
A4265_RS01195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4265_RS01230	COG0765	amino acid transport
A4265_RS01250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4265_RS01260	COG0719	Fe-S assembly protein
A4265_RS01265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4265_RS01280	COG1686	Belongs to the peptidase S11 family
A4265_RS01285	COG1686	Belongs to the peptidase S11 family
A4265_RS01290	COG4166	transmembrane transport
A4265_RS01295	COG0601	transmembrane transport
A4265_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4265_RS01305	COG0444	Belongs to the ABC transporter superfamily
A4265_RS01365	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4265_RS01370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A4265_RS01375	COG1534	Rna-binding protein
A4265_RS01385	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4265_RS01390	COG0799	negative regulation of ribosome biogenesis
A4265_RS01395	COG2226	methyltransferase
A4265_RS01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4265_RS01415	COG1464	Belongs to the NlpA lipoprotein family
A4265_RS01430	COG1114	Component of the transport system for branched-chain amino acids
A4265_RS01440	COG0569	domain protein
A4265_RS01445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4265_RS01455	COG1704	LemA family
A4265_RS01470	COG0745	RESPONSE REGULATOR receiver
A4265_RS01500	COG1484	DNA-dependent DNA replication
A4265_RS01510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4265_RS01530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4265_RS01545	COG1254	Belongs to the acylphosphatase family
A4265_RS01550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4265_RS01605	COG1187	pseudouridine synthase activity
A4265_RS01620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4265_RS01625	COG0671	phosphoesterase, PA-phosphatase related
A4265_RS01630	COG1242	4 iron, 4 sulfur cluster binding
A4265_RS01635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4265_RS01640	COG1253	flavin adenine dinucleotide binding
A4265_RS01645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4265_RS01660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4265_RS01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4265_RS01670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4265_RS01675	COG1120	ATPase activity
A4265_RS01685	COG2244	polysaccharide biosynthetic process
A4265_RS01710	COG0470	DNA polymerase III
A4265_RS01740	COG1393	Belongs to the ArsC family
A4265_RS01745	COG0708	Exodeoxyribonuclease III
A4265_RS01755	COG1304	FMN binding
A4265_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
A4265_RS01835	COG0673	inositol 2-dehydrogenase activity
A4265_RS01850	COG0494	nUDIX hydrolase
A4265_RS01860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4265_RS01950	COG1702	phosphate starvation-inducible protein PhoH
A4265_RS01955	COG1573	uracil-dna glycosylase
A4265_RS01965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4265_RS01980	COG2274	protein secretion by the type I secretion system
A4265_RS01985	COG2274	protein secretion by the type I secretion system
A4265_RS02020	COG2801	Transposase and inactivated derivatives
A4265_RS02025	COG2801	Transposase and inactivated derivatives
A4265_RS02035	COG3279	Response regulator of the LytR AlgR family
A4265_RS02050	COG2274	protein secretion by the type I secretion system
A4265_RS02140	COG0433	COG0433 Predicted ATPase
A4265_RS02145	COG2814	Major facilitator Superfamily
A4265_RS02155	COG0557	exoribonuclease II activity
A4265_RS02185	COG0463	Glycosyl transferase, family 2
A4265_RS02195	COG0778	Nitroreductase
A4265_RS02200	COG0006	proline dipeptidase activity
A4265_RS02205	COG1609	Transcriptional regulator
A4265_RS02215	COG0438	transferase activity, transferring glycosyl groups
A4265_RS02225	COG4555	ABC transporter
A4265_RS02245	COG0183	Belongs to the thiolase family
A4265_RS02260	COG0745	RESPONSE REGULATOR receiver
A4265_RS02265	COG5002	protein histidine kinase activity
A4265_RS02270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4265_RS02280	COG1196	nuclear chromosome segregation
A4265_RS02290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4265_RS02380	COG4695	Portal protein
A4265_RS02400	COG0561	phosphatase activity
A4265_RS02405	COG0561	phosphatase activity
A4265_RS02410	COG0552	protein localization to endoplasmic reticulum
A4265_RS02415	COG0477	Major facilitator Superfamily
A4265_RS02420	COG3711	transcriptional antiterminator
A4265_RS02425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4265_RS02425	COG1263	PTS System
A4265_RS02425	COG2190	(PTS) system
A4265_RS02435	COG3689	TIGRFAM TIGR03943 family protein
A4265_RS02440	COG0701	Predicted permease
A4265_RS02445	COG2183	response to ionizing radiation
A4265_RS02490	COG0826	peptidase U32
A4265_RS02495	COG4443	Transcriptional Coactivator p15 (PC4)
A4265_RS02540	COG0386	Belongs to the glutathione peroxidase family
A4265_RS02545	COG1164	Oligoendopeptidase f
A4265_RS02555	COG0772	Belongs to the SEDS family
A4265_RS02585	COG1078	dGTPase activity
A4265_RS02600	COG1609	Transcriptional regulator
A4265_RS02610	COG3716	PTS system mannose fructose sorbose family IID component
A4265_RS02615	COG3715	PTS system
A4265_RS02620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4265_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
A4265_RS02650	COG0800	Aldolase
A4265_RS02655	COG0546	phosphoglycolate phosphatase activity
A4265_RS02670	COG2884	Cell division ATP-binding protein ftsE
A4265_RS02675	COG2177	Part of the ABC transporter FtsEX involved in
A4265_RS02690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4265_RS02690	COG1199	ATP-dependent helicase activity
A4265_RS02695	COG0436	Aminotransferase
A4265_RS02730	COG2188	Transcriptional regulator
A4265_RS02735	COG2222	sugar isomerase
A4265_RS02745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4265_RS02750	COG0716	FMN binding
A4265_RS02760	COG0038	chloride channel
A4265_RS02845	COG1131	(ABC) transporter
A4265_RS02865	COG4708	membrane
A4265_RS02875	COG1597	lipid kinase activity
A4265_RS02960	COG0577	efflux transmembrane transporter activity
A4265_RS02970	COG2321	neutral zinc metallopeptidase
A4265_RS02985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4265_RS02995	COG1970	mechanosensitive ion channel activity
A4265_RS03000	COG0358	DNA primase activity
A4265_RS03005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4265_RS03010	COG2151	metal-sulfur cluster biosynthetic enzyme
A4265_RS03055	COG1216	Glycosyl transferase, family 2
A4265_RS03110	COG1368	sulfuric ester hydrolase activity
A4265_RS03115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4265_RS03135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4265_RS03140	COG0285	dihydrofolate synthase activity
A4265_RS03150	COG1104	cysteine desulfurase activity
A4265_RS03175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4265_RS03180	COG0583	DNA-binding transcription factor activity
A4265_RS03190	COG0564	pseudouridine synthase activity
A4265_RS03220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4265_RS03225	COG1136	(ABC) transporter
A4265_RS03230	COG0577	efflux transmembrane transporter activity
A4265_RS03235	COG0584	glycerophosphoryl diester phosphodiesterase
A4265_RS03245	COG1837	Belongs to the UPF0109 family
A4265_RS03295	COG1349	DNA-binding transcription factor activity
A4265_RS03300	COG1105	Belongs to the carbohydrate kinase PfkB family
A4265_RS03305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4265_RS03305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4265_RS03305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4265_RS03310	COG1388	LysM domain
A4265_RS03310	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4265_RS03315	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4265_RS03315	COG1388	LysM domain
A4265_RS03335	COG0105	UTP biosynthetic process
A4265_RS03355	COG0488	(ABC) transporter
A4265_RS03365	COG0242	peptide deformylase activity
A4265_RS03370	COG0737	Belongs to the 5'-nucleotidase family
A4265_RS03375	COG2357	RelA SpoT domain protein
A4265_RS03380	COG0745	RESPONSE REGULATOR receiver
A4265_RS03415	COG3425	synthase
A4265_RS03425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4265_RS03465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4265_RS03480	COG0583	DNA-binding transcription factor activity
A4265_RS03505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4265_RS03510	COG0765	amino acid transport
A4265_RS03530	COG0187	DNA topoisomerase II activity
A4265_RS03545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4265_RS03565	COG0539	negative regulation of cytoplasmic translation
A4265_RS03580	COG2801	Transposase and inactivated derivatives
A4265_RS03655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4265_RS03660	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A4265_RS03670	COG0300	oxidoreductase activity
A4265_RS03675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4265_RS03675	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4265_RS03690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4265_RS03695	COG2384	SAM-dependent methyltransferase
A4265_RS03705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4265_RS03710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4265_RS03720	COG1088	dTDP-glucose 4,6-dehydratase activity
A4265_RS03725	COG1051	belongs to the nudix hydrolase family
A4265_RS03730	COG0628	permease
A4265_RS03735	COG0457	Tetratricopeptide repeat
A4265_RS03740	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A4265_RS03760	COG1129	ABC transporter
A4265_RS03780	COG0488	(ABC) transporter
A4265_RS03785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4265_RS03790	COG0022	dehydrogenase e1 component
A4265_RS03790	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4265_RS03795	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4265_RS03810	COG5492	domain, Protein
A4265_RS03815	COG0095	Lipoate-protein ligase
A4265_RS03820	COG3442	glutamine amidotransferase
A4265_RS03825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4265_RS03830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4265_RS03850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4265_RS03860	COG0647	UMP catabolic process
A4265_RS03915	COG3715	PTS system
A4265_RS03920	COG3716	PTS system mannose fructose sorbose family IID component
A4265_RS03925	COG2972	Histidine kinase
A4265_RS03930	COG4753	response regulator
A4265_RS03930	COG2207	Transcriptional regulator
A4265_RS03940	COG1012	belongs to the aldehyde dehydrogenase family
A4265_RS03955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4265_RS04015	COG1131	(ABC) transporter
A4265_RS04030	COG1396	sequence-specific DNA binding
A4265_RS04065	COG0285	dihydrofolate synthase activity
A4265_RS04085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4265_RS04100	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4265_RS04105	COG1177	transmembrane transport
A4265_RS04115	COG4565	transcriptional regulatory protein
A4265_RS04120	COG3290	protein histidine kinase activity
A4265_RS04125	COG3493	citrate carrier protein
A4265_RS04140	COG3700	Belongs to the class B bacterial acid phosphatase family
A4265_RS04145	COG0038	chloride channel
A4265_RS04155	COG0628	permease
A4265_RS04165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4265_RS04180	COG1104	cysteine desulfurase activity
A4265_RS04195	COG2357	RelA SpoT domain protein
A4265_RS04205	COG0564	pseudouridine synthase activity
A4265_RS04210	COG0280	phosphate acetyltransferase
A4265_RS04215	COG4221	oxidoreductase activity
A4265_RS04230	COG1174	glycine betaine transport
A4265_RS04245	COG2233	PERMEase
A4265_RS04270	COG2890	protein-(glutamine-N5) methyltransferase activity
A4265_RS04300	COG1132	(ABC) transporter
A4265_RS04305	COG1132	(ABC) transporter
A4265_RS04325	COG3764	Sortase (surface protein transpeptidase)
A4265_RS04330	COG0346	lactoylglutathione lyase activity
A4265_RS04345	COG1272	protein, Hemolysin III
A4265_RS04365	COG0758	DNA mediated transformation
A4265_RS04370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4265_RS04390	COG0511	ligase activity, forming carbon-carbon bonds
A4265_RS04395	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4265_RS04410	COG2851	Citrate transporter
A4265_RS04420	COG0511	ligase activity, forming carbon-carbon bonds
A4265_RS04425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4265_RS04455	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A4265_RS04475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4265_RS04485	COG2188	Transcriptional regulator
A4265_RS04505	COG0488	(ABC) transporter
A4265_RS04515	COG0351	phosphomethylpyrimidine kinase
A4265_RS04515	COG0352	thiamine-phosphate diphosphorylase activity
A4265_RS04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4265_RS04525	COG1328	CTP reductase activity
A4265_RS04525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4265_RS04530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4265_RS04560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4265_RS04570	COG0095	Lipoate-protein ligase
A4265_RS04580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4265_RS04585	COG4684	Psort location CytoplasmicMembrane, score
A4265_RS04590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4265_RS04595	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4265_RS04600	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4265_RS04605	COG3845	ABC transporter
A4265_RS04610	COG1744	ABC transporter substrate-binding protein PnrA-like
A4265_RS04615	COG0295	cytidine deaminase activity
A4265_RS04620	COG2813	Specifically methylates the guanine in position
A4265_RS04635	COG5002	protein histidine kinase activity
A4265_RS04640	COG0745	RESPONSE REGULATOR receiver
A4265_RS04650	COG0704	Plays a role in the regulation of phosphate uptake
A4265_RS04665	COG0581	inorganic phosphate transmembrane transporter activity
A4265_RS04670	COG0573	inorganic phosphate transmembrane transporter activity
A4265_RS04680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4265_RS04680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4265_RS04685	COG0483	inositol monophosphate 1-phosphatase activity
A4265_RS04700	COG0196	riboflavin kinase activity
A4265_RS04780	COG1115	amino acid carrier protein
A4265_RS04785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4265_RS04795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4265_RS04800	COG1126	abc transporter atp-binding protein
A4265_RS04805	COG0765	amino acid transport
A4265_RS04810	COG2824	Alkylphosphonate utilization operon protein PhnA
A4265_RS04825	COG0469	pyruvate kinase activity
A4265_RS04840	COG1725	Transcriptional regulator
A4265_RS04845	COG1131	(ABC) transporter
A4265_RS04870	COG0058	SHG alpha-glucan phosphorylase activity
A4265_RS04875	COG1640	4-alpha-glucanotransferase
A4265_RS04880	COG1609	Transcriptional regulator
A4265_RS04885	COG2182	Extracellular solute-binding protein
A4265_RS04890	COG1175	transmembrane transport
A4265_RS04895	COG3833	ABC-type maltose transport systems, permease component
A4265_RS04910	COG3833	ABC-type maltose transport systems, permease component
A4265_RS04915	COG1175	transmembrane transport
A4265_RS04925	COG0366	Alpha amylase catalytic
A4265_RS04930	COG2182	Extracellular solute-binding protein
A4265_RS04940	COG0657	acetylesterase activity
A4265_RS04945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A4265_RS04955	COG1696	Membrane protein involved in D-alanine export
A4265_RS04975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4265_RS04980	COG1126	abc transporter atp-binding protein
A4265_RS04985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4265_RS04995	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4265_RS05005	COG3711	transcriptional antiterminator
A4265_RS05005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4265_RS05015	COG2723	6-phospho-beta-galactosidase activity
A4265_RS05035	COG2801	Transposase and inactivated derivatives
A4265_RS05040	COG0157	Belongs to the NadC ModD family
A4265_RS05060	COG1187	pseudouridine synthase activity
A4265_RS05070	COG2814	Major facilitator Superfamily
A4265_RS05120	COG4109	DRTGG domain
A4265_RS05150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4265_RS05150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4265_RS05155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4265_RS05160	COG1956	GAF domain-containing protein
A4265_RS05180	COG0513	Belongs to the DEAD box helicase family
A4265_RS05185	COG0726	polysaccharide deacetylase
A4265_RS05205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4265_RS05210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4265_RS05230	COG2801	Transposase and inactivated derivatives
A4265_RS05245	COG1476	TRANSCRIPTIONal
A4265_RS05260	COG4122	O-methyltransferase activity
A4265_RS05265	COG2223	nitrite transmembrane transporter activity
A4265_RS05280	COG1187	pseudouridine synthase activity
A4265_RS05325	COG0658	competence protein
A4265_RS05325	COG2333	competence protein COMEC
A4265_RS05330	COG1555	photosystem II stabilization
A4265_RS05330	COG1596	polysaccharide export
A4265_RS05335	COG0204	Acyl-transferase
A4265_RS05340	COG2890	protein-(glutamine-N5) methyltransferase activity
A4265_RS05355	COG0513	Belongs to the DEAD box helicase family
A4265_RS05370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4265_RS05385	COG0768	penicillin binding
A4265_RS05390	COG2116	formate transmembrane transporter activity
A4265_RS05400	COG1827	regulation of RNA biosynthetic process
A4265_RS05415	COG2217	Heavy metal translocating P-type atpase
A4265_RS05430	COG2755	lipolytic protein G-D-S-L family
A4265_RS05445	COG0497	DNA recombination
A4265_RS05450	COG1438	arginine binding
A4265_RS05455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4265_RS05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4265_RS05485	COG0415	Belongs to the DNA photolyase family
A4265_RS05495	COG0765	amino acid transport
A4265_RS05500	COG4703	Protein of unknown function (DUF1797)
A4265_RS05505	COG0542	response to heat
A4265_RS05510	COG0494	nUDIX hydrolase
A4265_RS05525	COG3599	regulation of cell shape
A4265_RS05530	COG2302	S4 RNA-binding domain
A4265_RS05545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4265_RS05580	COG1217	gtp-binding protein TYPA
A4265_RS05585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4265_RS05590	COG1940	carbohydrate kinase activity
A4265_RS05600	COG0783	Belongs to the Dps family
A4265_RS05615	COG4470	Protein conserved in bacteria
A4265_RS05620	COG1609	Transcriptional regulator
A4265_RS05625	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4265_RS05635	COG0742	ribosomal rna small subunit methyltransferase
A4265_RS05645	COG0549	Belongs to the carbamate kinase family
A4265_RS05650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4265_RS05655	COG1288	antiporter activity
A4265_RS05670	COG2235	arginine
A4265_RS05695	COG2972	Histidine kinase
A4265_RS05710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4265_RS05715	COG0785	Cytochrome C biogenesis protein
A4265_RS05725	COG0673	inositol 2-dehydrogenase activity
A4265_RS05765	COG1605	Chorismate mutase
A4265_RS05765	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4265_RS05785	COG2226	methyltransferase
A4265_RS05795	COG3250	beta-galactosidase activity
A4265_RS05800	COG2207	Transcriptional regulator
A4265_RS05800	COG4753	response regulator
A4265_RS05805	COG2972	Histidine kinase
A4265_RS05815	COG1653	transport
A4265_RS05820	COG0395	ABC-type sugar transport system, permease component
A4265_RS05825	COG1175	transmembrane transport
A4265_RS05830	COG1940	carbohydrate kinase activity
A4265_RS05835	COG2723	6-phospho-beta-galactosidase activity
A4265_RS05840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4265_RS05855	COG0383	alpha-mannosidase activity
A4265_RS05945	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A4265_RS05950	COG1739	Uncharacterized protein family UPF0029
A4265_RS05960	COG1185	polyribonucleotide nucleotidyltransferase activity
A4265_RS05970	COG2197	response regulator
A4265_RS05975	COG4585	Histidine kinase
A4265_RS05985	COG2815	serine threonine protein kinase
A4265_RS05985	COG0515	serine threonine protein kinase
A4265_RS05995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4265_RS05995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4265_RS06005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4265_RS06025	COG0583	DNA-binding transcription factor activity
A4265_RS06030	COG0183	Belongs to the thiolase family
A4265_RS06035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4265_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
A4265_RS06065	COG0116	Belongs to the methyltransferase superfamily
A4265_RS06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4265_RS06095	COG3579	cysteine-type endopeptidase activity
A4265_RS06105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4265_RS06110	COG1113	amino acid transport
A4265_RS06115	COG0492	ferredoxin-NADP+ reductase activity
A4265_RS06125	COG1126	abc transporter atp-binding protein
A4265_RS06135	COG0513	Belongs to the DEAD box helicase family
A4265_RS06145	COG0768	penicillin binding
A4265_RS06185	COG1131	(ABC) transporter
A4265_RS06210	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4265_RS06215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4265_RS06250	COG1755	Isoprenylcysteine carboxyl methyltransferase
A4265_RS06255	COG0656	L-ascorbic acid biosynthetic process
A4265_RS06265	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4265_RS06285	COG0561	phosphatase activity
A4265_RS06290	COG2860	membrane
A4265_RS06315	COG3775	system Galactitol-specific IIC component
A4265_RS06340	COG2217	Heavy metal translocating P-type atpase
A4265_RS06370	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4265_RS06375	COG0195	Participates in both transcription termination and antitermination
A4265_RS06400	COG4473	ABC transporter
A4265_RS06405	COG1131	(ABC) transporter
A4265_RS06410	COG0537	adenosine 5'-monophosphoramidase activity
A4265_RS06420	COG1316	TRANSCRIPTIONal
A4265_RS06430	COG0802	atpase or kinase
A4265_RS06435	COG2252	PERMEase
A4265_RS06440	COG0561	phosphatase activity
A4265_RS06450	COG3715	PTS system
A4265_RS06455	COG3716	PTS system mannose fructose sorbose family IID component
A4265_RS06480	COG0439	Biotin carboxylase
A4265_RS06495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4265_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
A4265_RS06505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4265_RS06530	COG1024	Enoyl-CoA hydratase
A4265_RS06565	COG0588	phosphoglycerate mutase activity
A4265_RS06570	COG2261	transglycosylase associated protein
A4265_RS06595	COG0574	Belongs to the PEP-utilizing enzyme family
A4265_RS06595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4265_RS06600	COG1335	isochorismatase
A4265_RS06610	COG0436	Aminotransferase
A4265_RS06620	COG0561	phosphatase activity
A4265_RS06625	COG0252	asparaginase activity
A4265_RS06640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4265_RS06645	COG1129	ABC transporter
A4265_RS06660	COG1132	(ABC) transporter
A4265_RS06665	COG4988	ABC transporter
A4265_RS06670	COG1120	ATPase activity
A4265_RS06695	COG3942	CHAP domain
A4265_RS06695	COG1388	LysM domain
A4265_RS06715	COG1482	cell wall glycoprotein biosynthetic process
A4265_RS06720	COG1940	carbohydrate kinase activity
A4265_RS06730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4265_RS06730	COG1263	PTS System
A4265_RS06730	COG2190	(PTS) system
A4265_RS06735	COG1621	beta-fructofuranosidase activity
A4265_RS06740	COG1609	Transcriptional regulator
A4265_RS06760	COG2131	deaminase
A4265_RS06765	COG0006	proline dipeptidase activity
A4265_RS06805	COG1194	a g-specific adenine glycosylase
A4265_RS06810	COG3620	sequence-specific DNA binding
A4265_RS06815	COG3118	belongs to the thioredoxin family
A4265_RS06845	COG0681	Belongs to the peptidase S26 family
A4265_RS06850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4265_RS06865	COG1882	Formate acetyltransferase
A4265_RS06870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4265_RS06885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4265_RS06890	COG2814	Major facilitator Superfamily
A4265_RS06895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4265_RS06920	COG0789	Transcriptional regulator
A4265_RS06935	COG2081	HI0933 family
A4265_RS06945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4265_RS06950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4265_RS06970	COG0456	acetyltransferase
A4265_RS06975	COG1214	PFAM Peptidase M22, glycoprotease
A4265_RS06990	COG0174	glutamine synthetase
A4265_RS06995	COG0789	Transcriptional regulator
A4265_RS07010	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4265_RS07065	COG0668	transmembrane transport
A4265_RS07075	COG4720	Psort location CytoplasmicMembrane, score
A4265_RS07080	COG0351	phosphomethylpyrimidine kinase
A4265_RS07130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4265_RS07160	COG0577	efflux transmembrane transporter activity
A4265_RS07165	COG1136	(ABC) transporter
A4265_RS07190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4265_RS07190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4265_RS07195	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4265_RS07245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4265_RS07250	COG1476	TRANSCRIPTIONal
A4265_RS07270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4265_RS07280	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A4265_RS07300	COG1045	serine acetyltransferase
A4265_RS07315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4265_RS07330	COG3711	transcriptional antiterminator
A4265_RS07360	COG1846	Transcriptional regulator
A4265_RS07380	COG4589	Belongs to the CDS family
A4265_RS07390	COG1862	Preprotein translocase
A4265_RS07400	COG1523	belongs to the glycosyl hydrolase 13 family
A4265_RS07410	COG3842	ATPase activity
A4265_RS07450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4265_RS07450	COG2190	(PTS) system
A4265_RS07450	COG1263	PTS System
A4265_RS07455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4265_RS07470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4265_RS07475	COG0512	Glutamine amidotransferase of anthranilate synthase
A4265_RS07480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4265_RS07515	COG0601	transmembrane transport
A4265_RS07525	COG1122	ATPase activity
A4265_RS07545	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4265_RS07575	COG3711	transcriptional antiterminator
A4265_RS07585	COG3942	CHAP domain
A4265_RS07585	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4265_RS07590	COG2205	protein histidine kinase activity
A4265_RS07595	COG0745	RESPONSE REGULATOR receiver
A4265_RS07600	COG0577	efflux transmembrane transporter activity
A4265_RS07605	COG1136	(ABC) transporter
A4265_RS07655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4265_RS07670	COG1882	Formate acetyltransferase
A4265_RS07675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4265_RS07680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4265_RS07685	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4265_RS07690	COG2390	Transcriptional regulator
A4265_RS07695	COG1349	DNA-binding transcription factor activity
A4265_RS07700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4265_RS07715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4265_RS07730	COG0564	pseudouridine synthase activity
A4265_RS07760	COG0542	response to heat
A4265_RS07765	COG4463	regulation of RNA biosynthetic process
A4265_RS07780	COG0450	alkyl hydroperoxide reductase
A4265_RS07795	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4265_RS07805	COG3404	Formiminotransferase-cyclodeaminase
A4265_RS07820	COG0531	amino acid
A4265_RS07850	COG3590	peptidase
A4265_RS07855	COG0366	Alpha amylase catalytic
A4265_RS07860	COG1263	PTS System
A4265_RS07860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4265_RS07865	COG2188	Transcriptional regulator
A4265_RS07875	COG2514	catechol 2,3-dioxygenase activity
A4265_RS07885	COG0602	queuosine metabolic process
A4265_RS07900	COG1328	CTP reductase activity
A4265_RS07925	COG1393	Belongs to the ArsC family
A4265_RS07950	COG2814	Major facilitator Superfamily
A4265_RS07960	COG0582	viral genome integration into host DNA
A4265_RS07965	COG3645	SOS response
A4265_RS08115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4265_RS08120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4265_RS08125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4265_RS08205	COG1511	domain protein
A4265_RS08225	COG0305	Participates in initiation and elongation during chromosome replication
A4265_RS08255	COG1760	l-serine dehydratase
A4265_RS08260	COG1760	l-serine dehydratase
A4265_RS08265	COG0741	lytic transglycosylase activity
A4265_RS08270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4265_RS08285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4265_RS08295	COG0612	Peptidase, M16
A4265_RS08310	COG5433	transposase activity
A4265_RS08315	COG1215	transferase activity, transferring glycosyl groups
A4265_RS08325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4265_RS08345	COG0517	IMP dehydrogenase activity
A4265_RS08345	COG0516	GMP reductase activity
A4265_RS08355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4265_RS08360	COG0488	(ABC) transporter
A4265_RS08395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4265_RS08400	COG1475	DNA binding
A4265_RS08410	COG0592	DNA-directed DNA polymerase activity
A4265_RS08420	COG0012	GTP binding
A4265_RS08430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4265_RS08435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4265_RS08460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4265_RS08465	COG0531	amino acid