locus-tag	class	description
SPY49_RS00010	COG0592	DNA-directed DNA polymerase activity
SPY49_RS00020	COG0012	GTP binding
SPY49_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPY49_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPY49_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPY49_RS00065	COG0531	amino acid
SPY49_RS00240	COG3942	CHAP domain
SPY49_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPY49_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPY49_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPY49_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPY49_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPY49_RS00335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPY49_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
SPY49_RS00350	COG1454	alcohol dehydrogenase
SPY49_RS00355	COG1064	alcohol dehydrogenase
SPY49_RS00360	COG0534	Mate efflux family protein
SPY49_RS00470	COG0201	protein transport
SPY49_RS00585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SPY49_RS00605	COG1121	(ABC) transporter
SPY49_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPY49_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPY49_RS00625	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPY49_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPY49_RS00650	COG1459	type II secretion system
SPY49_RS00655	COG4537	Required for transformation and DNA binding
SPY49_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPY49_RS00700	COG1363	Peptidase, m42
SPY49_RS00710	COG5433	transposase activity
SPY49_RS00720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPY49_RS00725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPY49_RS00735	COG1428	Deoxynucleoside kinase
SPY49_RS00740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPY49_RS00770	COG4509	Sortase family
SPY49_RS00795	COG2031	fatty acid transporter
SPY49_RS00810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPY49_RS00825	COG0251	oxidation-reduction process
SPY49_RS00840	COG1269	ATP hydrolysis coupled proton transport
SPY49_RS00845	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPY49_RS00855	COG1527	subunit (C
SPY49_RS00860	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPY49_RS00895	COG1744	ABC transporter substrate-binding protein PnrA-like
SPY49_RS00935	COG0626	cystathionine gamma-synthase activity
SPY49_RS00965	COG3623	hexulose-6-phosphate isomerase
SPY49_RS00985	COG3448	diguanylate cyclase activity
SPY49_RS00985	COG4175	Glycine betaine
SPY49_RS00995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPY49_RS00995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPY49_RS01015	COG3969	phosphoadenosine phosphosulfate
SPY49_RS01030	COG2801	Transposase and inactivated derivatives
SPY49_RS01035	COG2801	Transposase and inactivated derivatives
SPY49_RS01040	COG2801	Transposase and inactivated derivatives
SPY49_RS01055	COG0157	Belongs to the NadC ModD family
SPY49_RS01080	COG1268	BioY protein
SPY49_RS01085	COG1234	tRNA 3'-trailer cleavage
SPY49_RS01115	COG0705	Rhomboid family
SPY49_RS01115	COG0457	Tetratricopeptide repeat
SPY49_RS01135	COG1132	(ABC) transporter
SPY49_RS01140	COG1132	(ABC) transporter
SPY49_RS01175	COG3290	protein histidine kinase activity
SPY49_RS01200	COG1847	R3H domain protein
SPY49_RS01220	COG1175	transmembrane transport
SPY49_RS01225	COG0395	ABC-type sugar transport system, permease component
SPY49_RS01235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPY49_RS01250	COG0084	hydrolase, TatD family'
SPY49_RS01275	COG1564	THIamine pyrophosphokinase
SPY49_RS01290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPY49_RS01345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPY49_RS01355	COG0719	Fe-S assembly protein
SPY49_RS01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPY49_RS01375	COG1686	Belongs to the peptidase S11 family
SPY49_RS01385	COG4166	transmembrane transport
SPY49_RS01390	COG0601	transmembrane transport
SPY49_RS01395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPY49_RS01400	COG0444	Belongs to the ABC transporter superfamily
SPY49_RS01450	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPY49_RS01455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPY49_RS01460	COG1534	Rna-binding protein
SPY49_RS01470	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPY49_RS01475	COG0799	negative regulation of ribosome biogenesis
SPY49_RS01480	COG2226	methyltransferase
SPY49_RS01500	COG1464	Belongs to the NlpA lipoprotein family
SPY49_RS01515	COG1114	Component of the transport system for branched-chain amino acids
SPY49_RS01525	COG0569	domain protein
SPY49_RS01530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPY49_RS01540	COG1704	LemA family
SPY49_RS01555	COG0745	RESPONSE REGULATOR receiver
SPY49_RS01575	COG1484	DNA-dependent DNA replication
SPY49_RS01585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPY49_RS01605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPY49_RS01620	COG1254	Belongs to the acylphosphatase family
SPY49_RS01625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPY49_RS01680	COG1187	pseudouridine synthase activity
SPY49_RS01705	COG1242	4 iron, 4 sulfur cluster binding
SPY49_RS01710	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPY49_RS01715	COG1253	flavin adenine dinucleotide binding
SPY49_RS01720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPY49_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPY49_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPY49_RS01745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPY49_RS01750	COG1120	ATPase activity
SPY49_RS01760	COG2244	polysaccharide biosynthetic process
SPY49_RS01785	COG0470	DNA polymerase III
SPY49_RS01815	COG1393	Belongs to the ArsC family
SPY49_RS01820	COG0708	Exodeoxyribonuclease III
SPY49_RS01830	COG1304	FMN binding
SPY49_RS02005	COG0582	viral genome integration into host DNA
SPY49_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
SPY49_RS02020	COG0673	inositol 2-dehydrogenase activity
SPY49_RS02035	COG0494	nUDIX hydrolase
SPY49_RS02045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPY49_RS02110	COG2996	Protein conserved in bacteria
SPY49_RS02135	COG1702	phosphate starvation-inducible protein PhoH
SPY49_RS02140	COG1573	uracil-dna glycosylase
SPY49_RS02150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPY49_RS02175	COG3328	transposase activity
SPY49_RS02180	COG3328	transposase activity
SPY49_RS02245	COG0433	COG0433 Predicted ATPase
SPY49_RS02250	COG2814	Major facilitator Superfamily
SPY49_RS02260	COG0557	exoribonuclease II activity
SPY49_RS02290	COG0463	Glycosyl transferase, family 2
SPY49_RS02300	COG0778	Nitroreductase
SPY49_RS02305	COG0006	proline dipeptidase activity
SPY49_RS02310	COG1609	Transcriptional regulator
SPY49_RS02320	COG0438	transferase activity, transferring glycosyl groups
SPY49_RS02330	COG4555	ABC transporter
SPY49_RS02350	COG0183	Belongs to the thiolase family
SPY49_RS02365	COG0745	RESPONSE REGULATOR receiver
SPY49_RS02370	COG5002	protein histidine kinase activity
SPY49_RS02375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPY49_RS02385	COG1196	nuclear chromosome segregation
SPY49_RS02395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPY49_RS02475	COG4695	Portal protein
SPY49_RS02505	COG0124	histidyl-tRNA synthetase
SPY49_RS02520	COG0561	phosphatase activity
SPY49_RS02525	COG0561	phosphatase activity
SPY49_RS02530	COG0552	protein localization to endoplasmic reticulum
SPY49_RS02535	COG0477	Major facilitator Superfamily
SPY49_RS02540	COG3711	transcriptional antiterminator
SPY49_RS02545	COG1263	PTS System
SPY49_RS02545	COG2190	(PTS) system
SPY49_RS02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPY49_RS02555	COG3689	TIGRFAM TIGR03943 family protein
SPY49_RS02560	COG0701	Predicted permease
SPY49_RS02570	COG2183	response to ionizing radiation
SPY49_RS02615	COG0826	peptidase U32
SPY49_RS02670	COG0386	Belongs to the glutathione peroxidase family
SPY49_RS02675	COG1164	Oligoendopeptidase f
SPY49_RS02720	COG1078	dGTPase activity
SPY49_RS02735	COG1609	Transcriptional regulator
SPY49_RS02745	COG3716	PTS system mannose fructose sorbose family IID component
SPY49_RS02750	COG3715	PTS system
SPY49_RS02755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPY49_RS02770	COG1028	Short-chain dehydrogenase reductase Sdr
SPY49_RS02790	COG0546	phosphoglycolate phosphatase activity
SPY49_RS02795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPY49_RS02805	COG2884	Cell division ATP-binding protein ftsE
SPY49_RS02810	COG2177	Part of the ABC transporter FtsEX involved in
SPY49_RS02825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPY49_RS02825	COG1199	ATP-dependent helicase activity
SPY49_RS02830	COG0436	Aminotransferase
SPY49_RS02865	COG2188	Transcriptional regulator
SPY49_RS02870	COG2222	sugar isomerase
SPY49_RS02880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPY49_RS02885	COG0716	FMN binding
SPY49_RS02895	COG0038	chloride channel
SPY49_RS02980	COG1131	(ABC) transporter
SPY49_RS03000	COG4708	membrane
SPY49_RS03010	COG1597	lipid kinase activity
SPY49_RS03095	COG0577	efflux transmembrane transporter activity
SPY49_RS03105	COG2321	neutral zinc metallopeptidase
SPY49_RS03130	COG1970	mechanosensitive ion channel activity
SPY49_RS03135	COG0358	DNA primase activity
SPY49_RS03140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPY49_RS03145	COG2151	metal-sulfur cluster biosynthetic enzyme
SPY49_RS03190	COG1216	Glycosyl transferase, family 2
SPY49_RS03245	COG1368	sulfuric ester hydrolase activity
SPY49_RS03250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPY49_RS03270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPY49_RS03275	COG0285	dihydrofolate synthase activity
SPY49_RS03285	COG1104	cysteine desulfurase activity
SPY49_RS03310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPY49_RS03315	COG0583	DNA-binding transcription factor activity
SPY49_RS03325	COG0564	pseudouridine synthase activity
SPY49_RS03355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPY49_RS03360	COG1136	(ABC) transporter
SPY49_RS03365	COG0577	efflux transmembrane transporter activity
SPY49_RS03370	COG0584	glycerophosphoryl diester phosphodiesterase
SPY49_RS03380	COG1837	Belongs to the UPF0109 family
SPY49_RS03430	COG1349	DNA-binding transcription factor activity
SPY49_RS03435	COG1105	Belongs to the carbohydrate kinase PfkB family
SPY49_RS03440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPY49_RS03440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPY49_RS03440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPY49_RS03445	COG1388	LysM domain
SPY49_RS03445	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPY49_RS03450	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPY49_RS03450	COG1388	LysM domain
SPY49_RS03455	COG2801	Transposase and inactivated derivatives
SPY49_RS03470	COG0105	UTP biosynthetic process
SPY49_RS03490	COG0488	(ABC) transporter
SPY49_RS03495	COG0242	peptide deformylase activity
SPY49_RS03500	COG0737	Belongs to the 5'-nucleotidase family
SPY49_RS03505	COG2357	RelA SpoT domain protein
SPY49_RS03510	COG0745	RESPONSE REGULATOR receiver
SPY49_RS03545	COG3425	synthase
SPY49_RS03555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPY49_RS03610	COG0583	DNA-binding transcription factor activity
SPY49_RS03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPY49_RS03640	COG0765	amino acid transport
SPY49_RS03660	COG0187	DNA topoisomerase II activity
SPY49_RS03670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPY49_RS03690	COG0539	negative regulation of cytoplasmic translation
SPY49_RS03725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPY49_RS03730	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPY49_RS03745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPY49_RS03745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPY49_RS03760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPY49_RS03765	COG2384	SAM-dependent methyltransferase
SPY49_RS03775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPY49_RS03780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPY49_RS03790	COG1088	dTDP-glucose 4,6-dehydratase activity
SPY49_RS03795	COG0582	viral genome integration into host DNA
SPY49_RS03895	COG1783	phage Terminase large subunit
SPY49_RS03990	COG4824	toxin secretion phage lysis holin
SPY49_RS04015	COG1051	belongs to the nudix hydrolase family
SPY49_RS04020	COG0628	permease
SPY49_RS04025	COG0457	Tetratricopeptide repeat
SPY49_RS04030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPY49_RS04045	COG1129	ABC transporter
SPY49_RS04065	COG0488	(ABC) transporter
SPY49_RS04070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPY49_RS04075	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPY49_RS04075	COG0022	dehydrogenase e1 component
SPY49_RS04080	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPY49_RS04095	COG5492	domain, Protein
SPY49_RS04100	COG0095	Lipoate-protein ligase
SPY49_RS04105	COG3442	glutamine amidotransferase
SPY49_RS04110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPY49_RS04115	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPY49_RS04135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPY49_RS04145	COG0647	UMP catabolic process
SPY49_RS04160	COG1518	maintenance of DNA repeat elements
SPY49_RS04165	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPY49_RS04180	COG0105	UTP biosynthetic process
SPY49_RS04215	COG3715	PTS system
SPY49_RS04220	COG3716	PTS system mannose fructose sorbose family IID component
SPY49_RS04225	COG2972	Histidine kinase
SPY49_RS04230	COG4753	response regulator
SPY49_RS04230	COG2207	Transcriptional regulator
SPY49_RS04240	COG1012	belongs to the aldehyde dehydrogenase family
SPY49_RS04255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPY49_RS04290	COG0285	dihydrofolate synthase activity
SPY49_RS04325	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPY49_RS04330	COG1177	transmembrane transport
SPY49_RS04340	COG4565	transcriptional regulatory protein
SPY49_RS04345	COG3290	protein histidine kinase activity
SPY49_RS04350	COG3493	citrate carrier protein
SPY49_RS04365	COG3700	Belongs to the class B bacterial acid phosphatase family
SPY49_RS04370	COG0038	chloride channel
SPY49_RS04380	COG0628	permease
SPY49_RS04390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPY49_RS04405	COG1104	cysteine desulfurase activity
SPY49_RS04420	COG2357	RelA SpoT domain protein
SPY49_RS04430	COG0564	pseudouridine synthase activity
SPY49_RS04435	COG0280	phosphate acetyltransferase
SPY49_RS04440	COG4221	oxidoreductase activity
SPY49_RS04455	COG1174	glycine betaine transport
SPY49_RS04470	COG2233	PERMEase
SPY49_RS04495	COG2890	protein-(glutamine-N5) methyltransferase activity
SPY49_RS04525	COG1132	(ABC) transporter
SPY49_RS04530	COG1132	(ABC) transporter
SPY49_RS04550	COG3764	Sortase (surface protein transpeptidase)
SPY49_RS04555	COG0346	lactoylglutathione lyase activity
SPY49_RS04590	COG0758	DNA mediated transformation
SPY49_RS04595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPY49_RS04640	COG0511	ligase activity, forming carbon-carbon bonds
SPY49_RS04645	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPY49_RS04660	COG2851	Citrate transporter
SPY49_RS04675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPY49_RS04710	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPY49_RS04730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPY49_RS04740	COG2188	Transcriptional regulator
SPY49_RS04760	COG0488	(ABC) transporter
SPY49_RS04770	COG0352	thiamine-phosphate diphosphorylase activity
SPY49_RS04770	COG0351	phosphomethylpyrimidine kinase
SPY49_RS04775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPY49_RS04780	COG1328	CTP reductase activity
SPY49_RS04780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPY49_RS04785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPY49_RS04815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPY49_RS04825	COG0095	Lipoate-protein ligase
SPY49_RS04835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPY49_RS04840	COG4684	Psort location CytoplasmicMembrane, score
SPY49_RS04845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPY49_RS04850	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPY49_RS04855	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPY49_RS04860	COG3845	ABC transporter
SPY49_RS04865	COG1744	ABC transporter substrate-binding protein PnrA-like
SPY49_RS04870	COG0295	cytidine deaminase activity
SPY49_RS04875	COG2813	Specifically methylates the guanine in position
SPY49_RS04890	COG5002	protein histidine kinase activity
SPY49_RS04895	COG0745	RESPONSE REGULATOR receiver
SPY49_RS04905	COG0704	Plays a role in the regulation of phosphate uptake
SPY49_RS04920	COG0581	inorganic phosphate transmembrane transporter activity
SPY49_RS04925	COG0573	inorganic phosphate transmembrane transporter activity
SPY49_RS04935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPY49_RS04935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPY49_RS04940	COG0483	inositol monophosphate 1-phosphatase activity
SPY49_RS04955	COG0196	riboflavin kinase activity
SPY49_RS04985	COG1136	(ABC) transporter
SPY49_RS04985	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPY49_RS05035	COG1115	amino acid carrier protein
SPY49_RS05040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPY49_RS05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPY49_RS05055	COG1126	abc transporter atp-binding protein
SPY49_RS05060	COG0765	amino acid transport
SPY49_RS05065	COG2824	Alkylphosphonate utilization operon protein PhnA
SPY49_RS05080	COG0469	pyruvate kinase activity
SPY49_RS05095	COG1725	Transcriptional regulator
SPY49_RS05100	COG1131	(ABC) transporter
SPY49_RS05120	COG0058	SHG alpha-glucan phosphorylase activity
SPY49_RS05125	COG1640	4-alpha-glucanotransferase
SPY49_RS05130	COG1609	Transcriptional regulator
SPY49_RS05135	COG2182	Extracellular solute-binding protein
SPY49_RS05140	COG1175	transmembrane transport
SPY49_RS05145	COG3833	ABC-type maltose transport systems, permease component
SPY49_RS05160	COG0657	acetylesterase activity
SPY49_RS05165	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPY49_RS05175	COG1696	Membrane protein involved in D-alanine export
SPY49_RS05195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPY49_RS05200	COG1126	abc transporter atp-binding protein
SPY49_RS05205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPY49_RS05215	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPY49_RS05225	COG3711	transcriptional antiterminator
SPY49_RS05225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPY49_RS05235	COG2723	6-phospho-beta-galactosidase activity
SPY49_RS05260	COG2801	Transposase and inactivated derivatives
SPY49_RS05270	COG2801	Transposase and inactivated derivatives
SPY49_RS05275	COG0157	Belongs to the NadC ModD family
SPY49_RS05290	COG2801	Transposase and inactivated derivatives
SPY49_RS05295	COG2801	Transposase and inactivated derivatives
SPY49_RS05300	COG1187	pseudouridine synthase activity
SPY49_RS05310	COG2814	Major facilitator Superfamily
SPY49_RS05360	COG4109	DRTGG domain
SPY49_RS05395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPY49_RS05400	COG1956	GAF domain-containing protein
SPY49_RS05420	COG0513	Belongs to the DEAD box helicase family
SPY49_RS05425	COG0726	polysaccharide deacetylase
SPY49_RS05445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPY49_RS05450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPY49_RS05475	COG2801	Transposase and inactivated derivatives
SPY49_RS05480	COG2801	Transposase and inactivated derivatives
SPY49_RS05495	COG1476	TRANSCRIPTIONal
SPY49_RS05510	COG4122	O-methyltransferase activity
SPY49_RS05515	COG2223	nitrite transmembrane transporter activity
SPY49_RS05530	COG1187	pseudouridine synthase activity
SPY49_RS05575	COG0658	competence protein
SPY49_RS05575	COG2333	competence protein COMEC
SPY49_RS05580	COG1596	polysaccharide export
SPY49_RS05580	COG1555	photosystem II stabilization
SPY49_RS05585	COG0204	Acyl-transferase
SPY49_RS05590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPY49_RS05605	COG0513	Belongs to the DEAD box helicase family
SPY49_RS05620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPY49_RS05635	COG0768	penicillin binding
SPY49_RS05640	COG2116	formate transmembrane transporter activity
SPY49_RS05650	COG1827	regulation of RNA biosynthetic process
SPY49_RS05665	COG2217	Heavy metal translocating P-type atpase
SPY49_RS05680	COG2755	lipolytic protein G-D-S-L family
SPY49_RS05695	COG0497	DNA recombination
SPY49_RS05700	COG1438	arginine binding
SPY49_RS05705	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPY49_RS05730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPY49_RS05735	COG0415	Belongs to the DNA photolyase family
SPY49_RS05745	COG0765	amino acid transport
SPY49_RS05750	COG4703	Protein of unknown function (DUF1797)
SPY49_RS05755	COG0542	response to heat
SPY49_RS05760	COG0494	nUDIX hydrolase
SPY49_RS05775	COG3599	regulation of cell shape
SPY49_RS05780	COG2302	S4 RNA-binding domain
SPY49_RS05795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPY49_RS05830	COG1217	gtp-binding protein TYPA
SPY49_RS05835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPY49_RS05840	COG1940	carbohydrate kinase activity
SPY49_RS05850	COG0783	Belongs to the Dps family
SPY49_RS05865	COG4470	Protein conserved in bacteria
SPY49_RS05870	COG1609	Transcriptional regulator
SPY49_RS05875	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPY49_RS05885	COG0742	ribosomal rna small subunit methyltransferase
SPY49_RS05895	COG0549	Belongs to the carbamate kinase family
SPY49_RS05900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPY49_RS05915	COG0454	-acetyltransferase
SPY49_RS05945	COG2972	Histidine kinase
SPY49_RS05960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPY49_RS05965	COG0785	Cytochrome C biogenesis protein
SPY49_RS05970	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPY49_RS05975	COG1518	maintenance of DNA repeat elements
SPY49_RS06035	COG1605	Chorismate mutase
SPY49_RS06035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPY49_RS06055	COG2226	methyltransferase
SPY49_RS06065	COG3250	beta-galactosidase activity
SPY49_RS06070	COG2207	Transcriptional regulator
SPY49_RS06070	COG4753	response regulator
SPY49_RS06075	COG2972	Histidine kinase
SPY49_RS06085	COG1653	transport
SPY49_RS06090	COG0395	ABC-type sugar transport system, permease component
SPY49_RS06095	COG1175	transmembrane transport
SPY49_RS06105	COG2723	6-phospho-beta-galactosidase activity
SPY49_RS06110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPY49_RS06125	COG0383	alpha-mannosidase activity
SPY49_RS06210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPY49_RS06215	COG1739	Uncharacterized protein family UPF0029
SPY49_RS06225	COG1098	S1 RNA binding domain
SPY49_RS06235	COG2197	response regulator
SPY49_RS06240	COG4585	Histidine kinase
SPY49_RS06250	COG2815	serine threonine protein kinase
SPY49_RS06250	COG0515	serine threonine protein kinase
SPY49_RS06260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPY49_RS06260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPY49_RS06270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPY49_RS06290	COG0583	DNA-binding transcription factor activity
SPY49_RS06295	COG0183	Belongs to the thiolase family
SPY49_RS06300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPY49_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
SPY49_RS06315	COG2610	gluconate transmembrane transporter activity
SPY49_RS06330	COG0116	Belongs to the methyltransferase superfamily
SPY49_RS06350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPY49_RS06355	COG3579	cysteine-type endopeptidase activity
SPY49_RS06365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPY49_RS06370	COG1113	amino acid transport
SPY49_RS06375	COG0492	ferredoxin-NADP+ reductase activity
SPY49_RS06385	COG1126	abc transporter atp-binding protein
SPY49_RS06390	COG0765	amino acid transport
SPY49_RS06395	COG0513	Belongs to the DEAD box helicase family
SPY49_RS06405	COG0768	penicillin binding
SPY49_RS06440	COG1131	(ABC) transporter
SPY49_RS06465	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPY49_RS06470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPY49_RS06505	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPY49_RS06510	COG0656	L-ascorbic acid biosynthetic process
SPY49_RS06520	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPY49_RS06540	COG0561	phosphatase activity
SPY49_RS06545	COG2860	membrane
SPY49_RS06570	COG3775	system Galactitol-specific IIC component
SPY49_RS06595	COG2217	Heavy metal translocating P-type atpase
SPY49_RS06625	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPY49_RS06630	COG0195	Participates in both transcription termination and antitermination
SPY49_RS06655	COG4473	ABC transporter
SPY49_RS06660	COG1131	(ABC) transporter
SPY49_RS06665	COG0537	adenosine 5'-monophosphoramidase activity
SPY49_RS06675	COG1316	TRANSCRIPTIONal
SPY49_RS06685	COG0802	atpase or kinase
SPY49_RS06690	COG2252	PERMEase
SPY49_RS06705	COG3715	PTS system
SPY49_RS06710	COG3716	PTS system mannose fructose sorbose family IID component
SPY49_RS06735	COG0439	Biotin carboxylase
SPY49_RS06750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPY49_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
SPY49_RS06760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPY49_RS06785	COG1024	Enoyl-CoA hydratase
SPY49_RS06820	COG0588	phosphoglycerate mutase activity
SPY49_RS06825	COG2261	transglycosylase associated protein
SPY49_RS06850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPY49_RS06850	COG0574	Belongs to the PEP-utilizing enzyme family
SPY49_RS06855	COG1335	isochorismatase
SPY49_RS06875	COG0561	phosphatase activity
SPY49_RS06880	COG0252	asparaginase activity
SPY49_RS06895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPY49_RS06900	COG1129	ABC transporter
SPY49_RS06915	COG1132	(ABC) transporter
SPY49_RS06920	COG4988	ABC transporter
SPY49_RS06925	COG1120	ATPase activity
SPY49_RS06950	COG3942	CHAP domain
SPY49_RS06950	COG1388	LysM domain
SPY49_RS06975	COG5433	transposase activity
SPY49_RS06980	COG1482	cell wall glycoprotein biosynthetic process
SPY49_RS06985	COG1940	carbohydrate kinase activity
SPY49_RS06995	COG2190	(PTS) system
SPY49_RS06995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPY49_RS06995	COG1263	PTS System
SPY49_RS07000	COG1621	beta-fructofuranosidase activity
SPY49_RS07005	COG1609	Transcriptional regulator
SPY49_RS07025	COG2131	deaminase
SPY49_RS07030	COG0006	proline dipeptidase activity
SPY49_RS07070	COG1194	a g-specific adenine glycosylase
SPY49_RS07080	COG3118	belongs to the thioredoxin family
SPY49_RS07110	COG0681	Belongs to the peptidase S26 family
SPY49_RS07115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPY49_RS07130	COG1882	Formate acetyltransferase
SPY49_RS07150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPY49_RS07155	COG2814	Major facilitator Superfamily
SPY49_RS07160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPY49_RS07205	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPY49_RS07205	COG1388	LysM domain
SPY49_RS07485	COG3561	AntA/AntB antirepressor
SPY49_RS07540	COG0582	viral genome integration into host DNA
SPY49_RS07550	COG0789	Transcriptional regulator
SPY49_RS07575	COG5433	transposase activity
SPY49_RS07580	COG2081	HI0933 family
SPY49_RS07590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPY49_RS07595	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPY49_RS07615	COG0456	acetyltransferase
SPY49_RS07620	COG1214	PFAM Peptidase M22, glycoprotease
SPY49_RS07635	COG0174	glutamine synthetase
SPY49_RS07640	COG0789	Transcriptional regulator
SPY49_RS07655	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPY49_RS07710	COG0668	transmembrane transport
SPY49_RS07720	COG4720	Psort location CytoplasmicMembrane, score
SPY49_RS07725	COG0351	phosphomethylpyrimidine kinase
SPY49_RS07770	COG1929	Belongs to the glycerate kinase type-1 family
SPY49_RS07775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPY49_RS07805	COG0577	efflux transmembrane transporter activity
SPY49_RS07810	COG1136	(ABC) transporter
SPY49_RS07835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPY49_RS07835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPY49_RS07840	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPY49_RS07885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPY49_RS07890	COG1476	TRANSCRIPTIONal
SPY49_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPY49_RS07920	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPY49_RS07940	COG1045	serine acetyltransferase
SPY49_RS07955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPY49_RS07970	COG3711	transcriptional antiterminator
SPY49_RS07990	COG0431	NADPH-dependent FMN reductase
SPY49_RS07995	COG1846	Transcriptional regulator
SPY49_RS08015	COG4589	Belongs to the CDS family
SPY49_RS08025	COG1862	Preprotein translocase
SPY49_RS08035	COG1523	belongs to the glycosyl hydrolase 13 family
SPY49_RS08045	COG3842	ATPase activity
SPY49_RS08085	COG1263	PTS System
SPY49_RS08085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPY49_RS08085	COG2190	(PTS) system
SPY49_RS08090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPY49_RS08130	COG2801	Transposase and inactivated derivatives
SPY49_RS08140	COG2801	Transposase and inactivated derivatives
SPY49_RS08165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPY49_RS08170	COG0512	Glutamine amidotransferase of anthranilate synthase
SPY49_RS08175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPY49_RS08210	COG0601	transmembrane transport
SPY49_RS08220	COG1122	ATPase activity
SPY49_RS08240	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPY49_RS08270	COG3711	transcriptional antiterminator
SPY49_RS08280	COG3942	CHAP domain
SPY49_RS08280	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPY49_RS08285	COG2205	protein histidine kinase activity
SPY49_RS08290	COG0745	RESPONSE REGULATOR receiver
SPY49_RS08295	COG0577	efflux transmembrane transporter activity
SPY49_RS08300	COG1136	(ABC) transporter
SPY49_RS08360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPY49_RS08375	COG1882	Formate acetyltransferase
SPY49_RS08380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPY49_RS08385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPY49_RS08390	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPY49_RS08395	COG2390	Transcriptional regulator
SPY49_RS08400	COG1349	DNA-binding transcription factor activity
SPY49_RS08405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPY49_RS08415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPY49_RS08430	COG0564	pseudouridine synthase activity
SPY49_RS08460	COG0542	response to heat
SPY49_RS08465	COG4463	regulation of RNA biosynthetic process
SPY49_RS08485	COG5433	transposase activity
SPY49_RS08490	COG0450	alkyl hydroperoxide reductase
SPY49_RS08505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPY49_RS08515	COG3404	Formiminotransferase-cyclodeaminase
SPY49_RS08530	COG0531	amino acid
SPY49_RS08560	COG3590	peptidase
SPY49_RS08565	COG0366	Alpha amylase catalytic
SPY49_RS08570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPY49_RS08570	COG1263	PTS System
SPY49_RS08575	COG2188	Transcriptional regulator
SPY49_RS08585	COG2514	catechol 2,3-dioxygenase activity
SPY49_RS08595	COG0602	queuosine metabolic process
SPY49_RS08610	COG1328	CTP reductase activity
SPY49_RS08635	COG1393	Belongs to the ArsC family
SPY49_RS08650	COG0519	Catalyzes the synthesis of GMP from XMP
SPY49_RS08695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPY49_RS08700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPY49_RS08705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPY49_RS08790	COG1511	domain protein
SPY49_RS08810	COG0305	Participates in initiation and elongation during chromosome replication
SPY49_RS08840	COG1760	l-serine dehydratase
SPY49_RS08845	COG1760	l-serine dehydratase
SPY49_RS08850	COG0741	lytic transglycosylase activity
SPY49_RS08855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPY49_RS08870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPY49_RS08880	COG0612	Peptidase, M16
SPY49_RS08900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPY49_RS08920	COG0516	GMP reductase activity
SPY49_RS08920	COG0517	IMP dehydrogenase activity
SPY49_RS08930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPY49_RS08935	COG0488	(ABC) transporter
SPY49_RS08970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPY49_RS08975	COG1475	DNA binding