locus-tag	class	description
J7S31_RS00010	COG0592	DNA-directed DNA polymerase activity
J7S31_RS00020	COG0012	GTP binding
J7S31_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J7S31_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J7S31_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J7S31_RS00065	COG0531	amino acid
J7S31_RS00240	COG3942	CHAP domain
J7S31_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J7S31_RS00270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J7S31_RS00285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J7S31_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J7S31_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J7S31_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J7S31_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
J7S31_RS00355	COG1454	alcohol dehydrogenase
J7S31_RS00360	COG1064	alcohol dehydrogenase
J7S31_RS00365	COG0534	Mate efflux family protein
J7S31_RS00475	COG0201	protein transport
J7S31_RS00605	COG1121	(ABC) transporter
J7S31_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J7S31_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J7S31_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J7S31_RS00650	COG1459	type II secretion system
J7S31_RS00655	COG4537	Required for transformation and DNA binding
J7S31_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J7S31_RS00700	COG1363	Peptidase, m42
J7S31_RS00710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J7S31_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J7S31_RS00725	COG1428	Deoxynucleoside kinase
J7S31_RS00730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J7S31_RS00760	COG4509	Sortase family
J7S31_RS00785	COG2031	fatty acid transporter
J7S31_RS00800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J7S31_RS00815	COG0251	oxidation-reduction process
J7S31_RS00830	COG1269	ATP hydrolysis coupled proton transport
J7S31_RS00835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J7S31_RS00845	COG1527	subunit (C
J7S31_RS00850	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
J7S31_RS00885	COG1744	ABC transporter substrate-binding protein PnrA-like
J7S31_RS00925	COG0626	cystathionine gamma-synthase activity
J7S31_RS00955	COG3623	hexulose-6-phosphate isomerase
J7S31_RS00975	COG3448	diguanylate cyclase activity
J7S31_RS00975	COG4175	Glycine betaine
J7S31_RS00985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J7S31_RS00985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J7S31_RS01015	COG1268	BioY protein
J7S31_RS01020	COG1234	tRNA 3'-trailer cleavage
J7S31_RS01055	COG0457	Tetratricopeptide repeat
J7S31_RS01055	COG0705	Rhomboid family
J7S31_RS01075	COG1132	(ABC) transporter
J7S31_RS01080	COG1132	(ABC) transporter
J7S31_RS01090	COG0756	dUTP diphosphatase activity
J7S31_RS01115	COG3290	protein histidine kinase activity
J7S31_RS01140	COG1847	R3H domain protein
J7S31_RS01160	COG1175	transmembrane transport
J7S31_RS01165	COG0395	ABC-type sugar transport system, permease component
J7S31_RS01175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J7S31_RS01190	COG0084	hydrolase, TatD family'
J7S31_RS01215	COG1564	THIamine pyrophosphokinase
J7S31_RS01230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J7S31_RS01270	COG0765	amino acid transport
J7S31_RS01290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J7S31_RS01300	COG0719	Fe-S assembly protein
J7S31_RS01305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J7S31_RS01320	COG1686	Belongs to the peptidase S11 family
J7S31_RS01325	COG1686	Belongs to the peptidase S11 family
J7S31_RS01330	COG4166	transmembrane transport
J7S31_RS01335	COG0601	transmembrane transport
J7S31_RS01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J7S31_RS01345	COG0444	Belongs to the ABC transporter superfamily
J7S31_RS01395	COG5433	transposase activity
J7S31_RS01405	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
J7S31_RS01410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J7S31_RS01415	COG1534	Rna-binding protein
J7S31_RS01425	COG1713	HD superfamily hydrolase involved in NAD metabolism
J7S31_RS01430	COG0799	negative regulation of ribosome biogenesis
J7S31_RS01435	COG2226	methyltransferase
J7S31_RS01450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S31_RS01455	COG1464	Belongs to the NlpA lipoprotein family
J7S31_RS01470	COG1114	Component of the transport system for branched-chain amino acids
J7S31_RS01480	COG0569	domain protein
J7S31_RS01485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J7S31_RS01495	COG1704	LemA family
J7S31_RS01510	COG0745	RESPONSE REGULATOR receiver
J7S31_RS01530	COG1484	DNA-dependent DNA replication
J7S31_RS01540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J7S31_RS01560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J7S31_RS01575	COG1254	Belongs to the acylphosphatase family
J7S31_RS01580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J7S31_RS01635	COG1187	pseudouridine synthase activity
J7S31_RS01650	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
J7S31_RS01655	COG0671	phosphoesterase, PA-phosphatase related
J7S31_RS01660	COG1242	4 iron, 4 sulfur cluster binding
J7S31_RS01665	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
J7S31_RS01670	COG1253	flavin adenine dinucleotide binding
J7S31_RS01675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J7S31_RS01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7S31_RS01695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J7S31_RS01700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J7S31_RS01705	COG1120	ATPase activity
J7S31_RS01715	COG2244	polysaccharide biosynthetic process
J7S31_RS01740	COG0470	DNA polymerase III
J7S31_RS01770	COG1393	Belongs to the ArsC family
J7S31_RS01775	COG0708	Exodeoxyribonuclease III
J7S31_RS01780	COG1304	FMN binding
J7S31_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
J7S31_RS01845	COG0673	inositol 2-dehydrogenase activity
J7S31_RS01860	COG0494	nUDIX hydrolase
J7S31_RS01870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J7S31_RS01960	COG1702	phosphate starvation-inducible protein PhoH
J7S31_RS01965	COG1573	uracil-dna glycosylase
J7S31_RS01975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J7S31_RS02055	COG0433	COG0433 Predicted ATPase
J7S31_RS02060	COG2814	Major facilitator Superfamily
J7S31_RS02075	COG0557	exoribonuclease II activity
J7S31_RS02105	COG0463	Glycosyl transferase, family 2
J7S31_RS02115	COG0778	Nitroreductase
J7S31_RS02120	COG0006	proline dipeptidase activity
J7S31_RS02125	COG1609	Transcriptional regulator
J7S31_RS02135	COG0438	transferase activity, transferring glycosyl groups
J7S31_RS02145	COG4555	ABC transporter
J7S31_RS02165	COG0183	Belongs to the thiolase family
J7S31_RS02180	COG0745	RESPONSE REGULATOR receiver
J7S31_RS02185	COG5002	protein histidine kinase activity
J7S31_RS02190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J7S31_RS02200	COG1196	nuclear chromosome segregation
J7S31_RS02215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J7S31_RS02320	COG0561	phosphatase activity
J7S31_RS02325	COG0561	phosphatase activity
J7S31_RS02330	COG0552	protein localization to endoplasmic reticulum
J7S31_RS02335	COG0477	Major facilitator Superfamily
J7S31_RS02340	COG3711	transcriptional antiterminator
J7S31_RS02345	COG2190	(PTS) system
J7S31_RS02345	COG1263	PTS System
J7S31_RS02345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J7S31_RS02355	COG3689	TIGRFAM TIGR03943 family protein
J7S31_RS02360	COG0701	Predicted permease
J7S31_RS02370	COG2183	response to ionizing radiation
J7S31_RS02415	COG0826	peptidase U32
J7S31_RS02420	COG4443	Transcriptional Coactivator p15 (PC4)
J7S31_RS02470	COG0386	Belongs to the glutathione peroxidase family
J7S31_RS02475	COG1164	Oligoendopeptidase f
J7S31_RS02485	COG0772	Belongs to the SEDS family
J7S31_RS02515	COG1078	dGTPase activity
J7S31_RS02530	COG1609	Transcriptional regulator
J7S31_RS02540	COG3716	PTS system mannose fructose sorbose family IID component
J7S31_RS02545	COG3715	PTS system
J7S31_RS02550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J7S31_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
J7S31_RS02580	COG0800	Aldolase
J7S31_RS02585	COG0546	phosphoglycolate phosphatase activity
J7S31_RS02590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J7S31_RS02600	COG2884	Cell division ATP-binding protein ftsE
J7S31_RS02605	COG2177	Part of the ABC transporter FtsEX involved in
J7S31_RS02620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J7S31_RS02620	COG1199	ATP-dependent helicase activity
J7S31_RS02625	COG0436	Aminotransferase
J7S31_RS02660	COG2188	Transcriptional regulator
J7S31_RS02665	COG2222	sugar isomerase
J7S31_RS02675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J7S31_RS02680	COG0716	FMN binding
J7S31_RS02690	COG0038	chloride channel
J7S31_RS02765	COG1131	(ABC) transporter
J7S31_RS02785	COG4708	membrane
J7S31_RS02795	COG1597	lipid kinase activity
J7S31_RS02880	COG0577	efflux transmembrane transporter activity
J7S31_RS02905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S31_RS02915	COG1970	mechanosensitive ion channel activity
J7S31_RS02920	COG0358	DNA primase activity
J7S31_RS02925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J7S31_RS02930	COG2151	metal-sulfur cluster biosynthetic enzyme
J7S31_RS02975	COG1216	Glycosyl transferase, family 2
J7S31_RS03035	COG1368	sulfuric ester hydrolase activity
J7S31_RS03040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J7S31_RS03060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J7S31_RS03065	COG0285	dihydrofolate synthase activity
J7S31_RS03075	COG1104	cysteine desulfurase activity
J7S31_RS03100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J7S31_RS03105	COG0583	DNA-binding transcription factor activity
J7S31_RS03115	COG0564	pseudouridine synthase activity
J7S31_RS03145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J7S31_RS03150	COG1136	(ABC) transporter
J7S31_RS03155	COG0577	efflux transmembrane transporter activity
J7S31_RS03160	COG0584	glycerophosphoryl diester phosphodiesterase
J7S31_RS03170	COG1837	Belongs to the UPF0109 family
J7S31_RS03220	COG1349	DNA-binding transcription factor activity
J7S31_RS03225	COG1105	Belongs to the carbohydrate kinase PfkB family
J7S31_RS03230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J7S31_RS03230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J7S31_RS03230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J7S31_RS03235	COG1705	Flagellar rod assembly protein muramidase FlgJ
J7S31_RS03235	COG1388	LysM domain
J7S31_RS03240	COG1705	Flagellar rod assembly protein muramidase FlgJ
J7S31_RS03240	COG1388	LysM domain
J7S31_RS03260	COG0105	UTP biosynthetic process
J7S31_RS03280	COG0488	(ABC) transporter
J7S31_RS03290	COG0242	peptide deformylase activity
J7S31_RS03295	COG0737	Belongs to the 5'-nucleotidase family
J7S31_RS03300	COG2357	RelA SpoT domain protein
J7S31_RS03305	COG0745	RESPONSE REGULATOR receiver
J7S31_RS03340	COG3425	synthase
J7S31_RS03350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J7S31_RS03410	COG0583	DNA-binding transcription factor activity
J7S31_RS03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S31_RS03440	COG0765	amino acid transport
J7S31_RS03460	COG0187	DNA topoisomerase II activity
J7S31_RS03470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J7S31_RS03490	COG0539	negative regulation of cytoplasmic translation
J7S31_RS03530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J7S31_RS03535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
J7S31_RS03545	COG0300	oxidoreductase activity
J7S31_RS03550	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
J7S31_RS03550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J7S31_RS03565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J7S31_RS03570	COG2384	SAM-dependent methyltransferase
J7S31_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J7S31_RS03585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J7S31_RS03595	COG1088	dTDP-glucose 4,6-dehydratase activity
J7S31_RS03600	COG1051	belongs to the nudix hydrolase family
J7S31_RS03605	COG0628	permease
J7S31_RS03610	COG0457	Tetratricopeptide repeat
J7S31_RS03615	COG1293	RNA-binding protein homologous to eukaryotic snRNP
J7S31_RS03630	COG1129	ABC transporter
J7S31_RS03650	COG0488	(ABC) transporter
J7S31_RS03655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J7S31_RS03660	COG0022	dehydrogenase e1 component
J7S31_RS03660	COG0508	dehydrogenase complex catalyzes the overall conversion of
J7S31_RS03665	COG0508	dehydrogenase complex catalyzes the overall conversion of
J7S31_RS03680	COG0095	Lipoate-protein ligase
J7S31_RS03685	COG3442	glutamine amidotransferase
J7S31_RS03690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J7S31_RS03695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
J7S31_RS03715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J7S31_RS03725	COG0647	UMP catabolic process
J7S31_RS03740	COG1518	maintenance of DNA repeat elements
J7S31_RS03745	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J7S31_RS03795	COG3715	PTS system
J7S31_RS03800	COG3716	PTS system mannose fructose sorbose family IID component
J7S31_RS03805	COG2972	Histidine kinase
J7S31_RS03810	COG4753	response regulator
J7S31_RS03810	COG2207	Transcriptional regulator
J7S31_RS03835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7S31_RS03865	COG0285	dihydrofolate synthase activity
J7S31_RS03900	COG1176	ABC-type spermidine putrescine transport system, permease component I
J7S31_RS03905	COG1177	transmembrane transport
J7S31_RS03915	COG4565	transcriptional regulatory protein
J7S31_RS03920	COG3290	protein histidine kinase activity
J7S31_RS03925	COG3493	citrate carrier protein
J7S31_RS03940	COG3700	Belongs to the class B bacterial acid phosphatase family
J7S31_RS03945	COG0038	chloride channel
J7S31_RS03955	COG0628	permease
J7S31_RS03980	COG1104	cysteine desulfurase activity
J7S31_RS03995	COG2357	RelA SpoT domain protein
J7S31_RS04005	COG0564	pseudouridine synthase activity
J7S31_RS04010	COG0280	phosphate acetyltransferase
J7S31_RS04030	COG1174	glycine betaine transport
J7S31_RS04045	COG2233	PERMEase
J7S31_RS04070	COG2890	protein-(glutamine-N5) methyltransferase activity
J7S31_RS04105	COG1132	(ABC) transporter
J7S31_RS04125	COG3764	Sortase (surface protein transpeptidase)
J7S31_RS04130	COG0346	lactoylglutathione lyase activity
J7S31_RS04145	COG1272	protein, Hemolysin III
J7S31_RS04165	COG0758	DNA mediated transformation
J7S31_RS04170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J7S31_RS04190	COG0511	ligase activity, forming carbon-carbon bonds
J7S31_RS04195	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
J7S31_RS04210	COG2851	Citrate transporter
J7S31_RS04220	COG0511	ligase activity, forming carbon-carbon bonds
J7S31_RS04225	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
J7S31_RS04255	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
J7S31_RS04275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J7S31_RS04285	COG2188	Transcriptional regulator
J7S31_RS04305	COG0488	(ABC) transporter
J7S31_RS04315	COG0351	phosphomethylpyrimidine kinase
J7S31_RS04315	COG0352	thiamine-phosphate diphosphorylase activity
J7S31_RS04320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J7S31_RS04325	COG1328	CTP reductase activity
J7S31_RS04325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J7S31_RS04330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J7S31_RS04360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J7S31_RS04380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J7S31_RS04385	COG4684	Psort location CytoplasmicMembrane, score
J7S31_RS04390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J7S31_RS04395	COG1079	Belongs to the binding-protein-dependent transport system permease family
J7S31_RS04400	COG4603	Belongs to the binding-protein-dependent transport system permease family
J7S31_RS04405	COG3845	ABC transporter
J7S31_RS04410	COG1744	ABC transporter substrate-binding protein PnrA-like
J7S31_RS04415	COG0295	cytidine deaminase activity
J7S31_RS04420	COG2813	Specifically methylates the guanine in position
J7S31_RS04435	COG5002	protein histidine kinase activity
J7S31_RS04440	COG0745	RESPONSE REGULATOR receiver
J7S31_RS04450	COG0704	Plays a role in the regulation of phosphate uptake
J7S31_RS04465	COG0581	inorganic phosphate transmembrane transporter activity
J7S31_RS04470	COG0573	inorganic phosphate transmembrane transporter activity
J7S31_RS04480	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
J7S31_RS04480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J7S31_RS04485	COG0483	inositol monophosphate 1-phosphatase activity
J7S31_RS04500	COG0196	riboflavin kinase activity
J7S31_RS04530	COG1136	(ABC) transporter
J7S31_RS04530	COG4591	ABC-type transport system involved in lipoprotein release permease component
J7S31_RS04580	COG1115	amino acid carrier protein
J7S31_RS04585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J7S31_RS04595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S31_RS04600	COG1126	abc transporter atp-binding protein
J7S31_RS04605	COG0765	amino acid transport
J7S31_RS04610	COG2824	Alkylphosphonate utilization operon protein PhnA
J7S31_RS04625	COG0469	pyruvate kinase activity
J7S31_RS04640	COG1725	Transcriptional regulator
J7S31_RS04645	COG1131	(ABC) transporter
J7S31_RS04670	COG0058	SHG alpha-glucan phosphorylase activity
J7S31_RS04675	COG1640	4-alpha-glucanotransferase
J7S31_RS04680	COG1609	Transcriptional regulator
J7S31_RS04685	COG2182	Extracellular solute-binding protein
J7S31_RS04690	COG1175	transmembrane transport
J7S31_RS04695	COG3833	ABC-type maltose transport systems, permease component
J7S31_RS04710	COG0657	acetylesterase activity
J7S31_RS04715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
J7S31_RS04725	COG1696	Membrane protein involved in D-alanine export
J7S31_RS04745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J7S31_RS04750	COG1126	abc transporter atp-binding protein
J7S31_RS04760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J7S31_RS04770	COG1447	Phosphotransferase system cellobiose-specific component IIA
J7S31_RS04790	COG2723	6-phospho-beta-galactosidase activity
J7S31_RS04820	COG0157	Belongs to the NadC ModD family
J7S31_RS04835	COG1187	pseudouridine synthase activity
J7S31_RS04845	COG2814	Major facilitator Superfamily
J7S31_RS04895	COG4109	DRTGG domain
J7S31_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J7S31_RS04930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J7S31_RS04930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J7S31_RS04940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J7S31_RS04945	COG1956	GAF domain-containing protein
J7S31_RS04965	COG0513	Belongs to the DEAD box helicase family
J7S31_RS04970	COG0726	polysaccharide deacetylase
J7S31_RS04990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J7S31_RS04995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J7S31_RS05000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J7S31_RS05025	COG1476	TRANSCRIPTIONal
J7S31_RS05040	COG4122	O-methyltransferase activity
J7S31_RS05045	COG2223	nitrite transmembrane transporter activity
J7S31_RS05060	COG1187	pseudouridine synthase activity
J7S31_RS05105	COG2333	competence protein COMEC
J7S31_RS05105	COG0658	competence protein
J7S31_RS05110	COG1596	polysaccharide export
J7S31_RS05110	COG1555	photosystem II stabilization
J7S31_RS05115	COG0204	Acyl-transferase
J7S31_RS05120	COG2890	protein-(glutamine-N5) methyltransferase activity
J7S31_RS05135	COG0513	Belongs to the DEAD box helicase family
J7S31_RS05150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J7S31_RS05165	COG2116	formate transmembrane transporter activity
J7S31_RS05175	COG1827	regulation of RNA biosynthetic process
J7S31_RS05190	COG2217	Heavy metal translocating P-type atpase
J7S31_RS05210	COG4824	toxin secretion phage lysis holin
J7S31_RS05395	COG3723	Recombinational DNA repair protein, rece pathway
J7S31_RS05445	COG1396	sequence-specific DNA binding
J7S31_RS05455	COG0582	viral genome integration into host DNA
J7S31_RS05470	COG2755	lipolytic protein G-D-S-L family
J7S31_RS05485	COG0497	DNA recombination
J7S31_RS05490	COG1438	arginine binding
J7S31_RS05495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
J7S31_RS05520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J7S31_RS05525	COG0415	Belongs to the DNA photolyase family
J7S31_RS05535	COG0765	amino acid transport
J7S31_RS05540	COG4703	Protein of unknown function (DUF1797)
J7S31_RS05545	COG0542	response to heat
J7S31_RS05550	COG0494	nUDIX hydrolase
J7S31_RS05565	COG3599	regulation of cell shape
J7S31_RS05570	COG2302	S4 RNA-binding domain
J7S31_RS05585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J7S31_RS05610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J7S31_RS05620	COG1217	gtp-binding protein TYPA
J7S31_RS05625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J7S31_RS05630	COG1940	carbohydrate kinase activity
J7S31_RS05640	COG0783	Belongs to the Dps family
J7S31_RS05655	COG4470	Protein conserved in bacteria
J7S31_RS05660	COG1609	Transcriptional regulator
J7S31_RS05665	COG3480	Lon protease (S16) C-terminal proteolytic domain
J7S31_RS05675	COG0742	ribosomal rna small subunit methyltransferase
J7S31_RS05685	COG0549	Belongs to the carbamate kinase family
J7S31_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J7S31_RS05695	COG1288	antiporter activity
J7S31_RS05735	COG2972	Histidine kinase
J7S31_RS05775	COG1388	LysM domain
J7S31_RS05775	COG0860	N-Acetylmuramoyl-L-alanine amidase
J7S31_RS05915	COG1475	DNA binding
J7S31_RS06010	COG3935	DnaD domain protein
J7S31_RS06045	COG3561	AntA/AntB antirepressor
J7S31_RS06055	COG1396	sequence-specific DNA binding
J7S31_RS06080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J7S31_RS06085	COG0785	Cytochrome C biogenesis protein
J7S31_RS06095	COG0673	inositol 2-dehydrogenase activity
J7S31_RS06135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J7S31_RS06135	COG1605	Chorismate mutase
J7S31_RS06155	COG2226	methyltransferase
J7S31_RS06165	COG3250	beta-galactosidase activity
J7S31_RS06170	COG4753	response regulator
J7S31_RS06170	COG2207	Transcriptional regulator
J7S31_RS06175	COG2972	Histidine kinase
J7S31_RS06185	COG1653	transport
J7S31_RS06190	COG0395	ABC-type sugar transport system, permease component
J7S31_RS06195	COG1175	transmembrane transport
J7S31_RS06200	COG1940	carbohydrate kinase activity
J7S31_RS06205	COG2723	6-phospho-beta-galactosidase activity
J7S31_RS06210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J7S31_RS06215	COG1609	Transcriptional regulator
J7S31_RS06225	COG0383	alpha-mannosidase activity
J7S31_RS06600	COG1739	Uncharacterized protein family UPF0029
J7S31_RS06610	COG1098	S1 RNA binding domain
J7S31_RS06620	COG2197	response regulator
J7S31_RS06625	COG4585	Histidine kinase
J7S31_RS06635	COG0515	serine threonine protein kinase
J7S31_RS06635	COG2815	serine threonine protein kinase
J7S31_RS06645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J7S31_RS06645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J7S31_RS06655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J7S31_RS06675	COG0583	DNA-binding transcription factor activity
J7S31_RS06680	COG0183	Belongs to the thiolase family
J7S31_RS06685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J7S31_RS06700	COG2610	gluconate transmembrane transporter activity
J7S31_RS06715	COG0116	Belongs to the methyltransferase superfamily
J7S31_RS06740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J7S31_RS06745	COG3579	cysteine-type endopeptidase activity
J7S31_RS06755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J7S31_RS06760	COG1113	amino acid transport
J7S31_RS06765	COG0492	ferredoxin-NADP+ reductase activity
J7S31_RS06775	COG1126	abc transporter atp-binding protein
J7S31_RS06785	COG0513	Belongs to the DEAD box helicase family
J7S31_RS06795	COG0768	penicillin binding
J7S31_RS06845	COG0860	N-Acetylmuramoyl-L-alanine amidase
J7S31_RS06845	COG1388	LysM domain
J7S31_RS06960	COG1783	phage Terminase large subunit
J7S31_RS07080	COG1131	(ABC) transporter
J7S31_RS07105	COG0446	pyridine nucleotide-disulphide oxidoreductase
J7S31_RS07110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J7S31_RS07145	COG1755	Isoprenylcysteine carboxyl methyltransferase
J7S31_RS07150	COG0656	L-ascorbic acid biosynthetic process
J7S31_RS07160	COG1283	sodium-dependent phosphate transmembrane transporter activity
J7S31_RS07180	COG0561	phosphatase activity
J7S31_RS07185	COG2860	membrane
J7S31_RS07195	COG1105	Belongs to the carbohydrate kinase PfkB family
J7S31_RS07235	COG2217	Heavy metal translocating P-type atpase
J7S31_RS07265	COG2740	Nucleic-acid-binding protein implicated in transcription termination
J7S31_RS07270	COG0195	Participates in both transcription termination and antitermination
J7S31_RS07295	COG4473	ABC transporter
J7S31_RS07300	COG1131	(ABC) transporter
J7S31_RS07305	COG0537	adenosine 5'-monophosphoramidase activity
J7S31_RS07315	COG1316	TRANSCRIPTIONal
J7S31_RS07325	COG0802	atpase or kinase
J7S31_RS07330	COG2252	PERMEase
J7S31_RS07335	COG0561	phosphatase activity
J7S31_RS07345	COG3715	PTS system
J7S31_RS07350	COG3716	PTS system mannose fructose sorbose family IID component
J7S31_RS07360	COG5433	transposase activity
J7S31_RS07385	COG0439	Biotin carboxylase
J7S31_RS07400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J7S31_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
J7S31_RS07410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J7S31_RS07435	COG1024	Enoyl-CoA hydratase
J7S31_RS07470	COG0588	phosphoglycerate mutase activity
J7S31_RS07475	COG2261	transglycosylase associated protein
J7S31_RS07500	COG0574	Belongs to the PEP-utilizing enzyme family
J7S31_RS07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J7S31_RS07505	COG1335	isochorismatase
J7S31_RS07515	COG0436	Aminotransferase
J7S31_RS07525	COG0561	phosphatase activity
J7S31_RS07530	COG0252	asparaginase activity
J7S31_RS07545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J7S31_RS07550	COG1129	ABC transporter
J7S31_RS07565	COG1132	(ABC) transporter
J7S31_RS07570	COG4988	ABC transporter
J7S31_RS07575	COG1120	ATPase activity
J7S31_RS07595	COG3942	CHAP domain
J7S31_RS07595	COG1388	LysM domain
J7S31_RS07615	COG1482	cell wall glycoprotein biosynthetic process
J7S31_RS07620	COG1940	carbohydrate kinase activity
J7S31_RS07630	COG2190	(PTS) system
J7S31_RS07630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J7S31_RS07630	COG1263	PTS System
J7S31_RS07635	COG1621	beta-fructofuranosidase activity
J7S31_RS07640	COG1609	Transcriptional regulator
J7S31_RS07660	COG2131	deaminase
J7S31_RS07665	COG0006	proline dipeptidase activity
J7S31_RS07705	COG1194	a g-specific adenine glycosylase
J7S31_RS07710	COG3620	sequence-specific DNA binding
J7S31_RS07715	COG3118	belongs to the thioredoxin family
J7S31_RS07745	COG0681	Belongs to the peptidase S26 family
J7S31_RS07750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J7S31_RS07765	COG1882	Formate acetyltransferase
J7S31_RS07770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J7S31_RS07785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J7S31_RS07790	COG2814	Major facilitator Superfamily
J7S31_RS07795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J7S31_RS07820	COG0789	Transcriptional regulator
J7S31_RS07835	COG2081	HI0933 family
J7S31_RS07845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J7S31_RS07850	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
J7S31_RS07870	COG0456	acetyltransferase
J7S31_RS07875	COG1214	PFAM Peptidase M22, glycoprotease
J7S31_RS07890	COG0174	glutamine synthetase
J7S31_RS07895	COG0789	Transcriptional regulator
J7S31_RS07910	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J7S31_RS07965	COG0668	transmembrane transport
J7S31_RS07975	COG4720	Psort location CytoplasmicMembrane, score
J7S31_RS07980	COG0351	phosphomethylpyrimidine kinase
J7S31_RS08025	COG1929	Belongs to the glycerate kinase type-1 family
J7S31_RS08030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J7S31_RS08060	COG1136	(ABC) transporter
J7S31_RS08090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J7S31_RS08090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J7S31_RS08095	COG1447	Phosphotransferase system cellobiose-specific component IIA
J7S31_RS08145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J7S31_RS08150	COG1476	TRANSCRIPTIONal
J7S31_RS08180	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
J7S31_RS08195	COG1045	serine acetyltransferase
J7S31_RS08210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J7S31_RS08225	COG3711	transcriptional antiterminator
J7S31_RS08250	COG0431	NADPH-dependent FMN reductase
J7S31_RS08255	COG1846	Transcriptional regulator
J7S31_RS08275	COG4589	Belongs to the CDS family
J7S31_RS08285	COG1862	Preprotein translocase
J7S31_RS08295	COG1523	belongs to the glycosyl hydrolase 13 family
J7S31_RS08305	COG3842	ATPase activity
J7S31_RS08345	COG5433	transposase activity
J7S31_RS08365	COG1263	PTS System
J7S31_RS08365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J7S31_RS08365	COG2190	(PTS) system
J7S31_RS08370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J7S31_RS08385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J7S31_RS08390	COG0512	Glutamine amidotransferase of anthranilate synthase
J7S31_RS08395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J7S31_RS08420	COG0601	transmembrane transport
J7S31_RS08450	COG0803	Belongs to the bacterial solute-binding protein 9 family
J7S31_RS08470	COG3711	transcriptional antiterminator
J7S31_RS08480	COG1705	Flagellar rod assembly protein muramidase FlgJ
J7S31_RS08480	COG3942	CHAP domain
J7S31_RS08485	COG2205	protein histidine kinase activity
J7S31_RS08490	COG0745	RESPONSE REGULATOR receiver
J7S31_RS08495	COG0577	efflux transmembrane transporter activity
J7S31_RS08500	COG1136	(ABC) transporter
J7S31_RS08555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J7S31_RS08570	COG1882	Formate acetyltransferase
J7S31_RS08575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J7S31_RS08580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J7S31_RS08585	COG1447	Phosphotransferase system cellobiose-specific component IIA
J7S31_RS08590	COG2390	Transcriptional regulator
J7S31_RS08595	COG1349	DNA-binding transcription factor activity
J7S31_RS08600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J7S31_RS08615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J7S31_RS08630	COG0564	pseudouridine synthase activity
J7S31_RS08665	COG0542	response to heat
J7S31_RS08670	COG4463	regulation of RNA biosynthetic process
J7S31_RS08685	COG0450	alkyl hydroperoxide reductase
J7S31_RS08700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J7S31_RS08710	COG3404	Formiminotransferase-cyclodeaminase
J7S31_RS08725	COG0531	amino acid
J7S31_RS08755	COG3590	peptidase
J7S31_RS08760	COG0366	Alpha amylase catalytic
J7S31_RS08765	COG1263	PTS System
J7S31_RS08765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J7S31_RS08770	COG2188	Transcriptional regulator
J7S31_RS08775	COG1733	regulation of RNA biosynthetic process
J7S31_RS08780	COG2514	catechol 2,3-dioxygenase activity
J7S31_RS08790	COG0602	queuosine metabolic process
J7S31_RS08810	COG1328	CTP reductase activity
J7S31_RS08835	COG1393	Belongs to the ArsC family
J7S31_RS08850	COG0519	Catalyzes the synthesis of GMP from XMP
J7S31_RS08895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J7S31_RS08900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J7S31_RS08905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J7S31_RS08990	COG1511	domain protein
J7S31_RS09010	COG0305	Participates in initiation and elongation during chromosome replication
J7S31_RS09040	COG1760	l-serine dehydratase
J7S31_RS09045	COG1760	l-serine dehydratase
J7S31_RS09050	COG0741	lytic transglycosylase activity
J7S31_RS09055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J7S31_RS09070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J7S31_RS09080	COG0612	Peptidase, M16
J7S31_RS09130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J7S31_RS09135	COG0488	(ABC) transporter
J7S31_RS09170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J7S31_RS09175	COG1475	DNA binding