locus-tag	class	description
SPS_RS00010	COG0592	DNA-directed DNA polymerase activity
SPS_RS00020	COG0012	GTP binding
SPS_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPS_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPS_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPS_RS00065	COG0531	amino acid
SPS_RS00175	COG3942	CHAP domain
SPS_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPS_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPS_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPS_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPS_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPS_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPS_RS00285	COG1454	alcohol dehydrogenase
SPS_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
SPS_RS00290	COG1064	alcohol dehydrogenase
SPS_RS00295	COG0534	Mate efflux family protein
SPS_RS00405	COG0201	protein transport
SPS_RS00540	COG1121	(ABC) transporter
SPS_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPS_RS00560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPS_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPS_RS00585	COG1459	type II secretion system
SPS_RS00590	COG4537	Required for transformation and DNA binding
SPS_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPS_RS00635	COG1363	Peptidase, m42
SPS_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPS_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPS_RS00665	COG1428	Deoxynucleoside kinase
SPS_RS00670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPS_RS00700	COG4509	Sortase family
SPS_RS00725	COG2031	fatty acid transporter
SPS_RS00740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPS_RS00755	COG0251	oxidation-reduction process
SPS_RS00770	COG1269	ATP hydrolysis coupled proton transport
SPS_RS00775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPS_RS00785	COG1527	subunit (C
SPS_RS00790	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPS_RS00825	COG1744	ABC transporter substrate-binding protein PnrA-like
SPS_RS00860	COG0626	cystathionine gamma-synthase activity
SPS_RS00890	COG3623	hexulose-6-phosphate isomerase
SPS_RS00910	COG3448	diguanylate cyclase activity
SPS_RS00910	COG4175	Glycine betaine
SPS_RS00920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPS_RS00920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPS_RS00950	COG1268	BioY protein
SPS_RS00955	COG1234	tRNA 3'-trailer cleavage
SPS_RS00990	COG0705	Rhomboid family
SPS_RS00990	COG0457	Tetratricopeptide repeat
SPS_RS01010	COG1132	(ABC) transporter
SPS_RS01015	COG1132	(ABC) transporter
SPS_RS01025	COG0756	dUTP diphosphatase activity
SPS_RS01050	COG3290	protein histidine kinase activity
SPS_RS01075	COG1847	R3H domain protein
SPS_RS01100	COG1175	transmembrane transport
SPS_RS01105	COG0395	ABC-type sugar transport system, permease component
SPS_RS01115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPS_RS01130	COG0084	hydrolase, TatD family'
SPS_RS01155	COG1564	THIamine pyrophosphokinase
SPS_RS01170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPS_RS01205	COG0765	amino acid transport
SPS_RS01225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPS_RS01235	COG0719	Fe-S assembly protein
SPS_RS01240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPS_RS01255	COG1686	Belongs to the peptidase S11 family
SPS_RS01260	COG1686	Belongs to the peptidase S11 family
SPS_RS01265	COG4166	transmembrane transport
SPS_RS01270	COG0601	transmembrane transport
SPS_RS01275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPS_RS01280	COG0444	Belongs to the ABC transporter superfamily
SPS_RS01335	COG0351	phosphomethylpyrimidine kinase
SPS_RS01340	COG4720	Psort location CytoplasmicMembrane, score
SPS_RS01350	COG0668	transmembrane transport
SPS_RS01405	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPS_RS01420	COG0789	Transcriptional regulator
SPS_RS01425	COG0174	glutamine synthetase
SPS_RS01440	COG1214	PFAM Peptidase M22, glycoprotease
SPS_RS01445	COG0456	acetyltransferase
SPS_RS01465	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPS_RS01470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPS_RS01480	COG2081	HI0933 family
SPS_RS01495	COG0789	Transcriptional regulator
SPS_RS01520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPS_RS01525	COG2814	Major facilitator Superfamily
SPS_RS01530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPS_RS01545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPS_RS01550	COG1882	Formate acetyltransferase
SPS_RS01565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPS_RS01570	COG0681	Belongs to the peptidase S26 family
SPS_RS01600	COG3118	belongs to the thioredoxin family
SPS_RS01605	COG3620	sequence-specific DNA binding
SPS_RS01610	COG1194	a g-specific adenine glycosylase
SPS_RS01650	COG0006	proline dipeptidase activity
SPS_RS01655	COG2131	deaminase
SPS_RS01675	COG1609	Transcriptional regulator
SPS_RS01680	COG1621	beta-fructofuranosidase activity
SPS_RS01685	COG1263	PTS System
SPS_RS01685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS_RS01685	COG2190	(PTS) system
SPS_RS01695	COG1940	carbohydrate kinase activity
SPS_RS01700	COG1482	cell wall glycoprotein biosynthetic process
SPS_RS01720	COG1388	LysM domain
SPS_RS01720	COG3942	CHAP domain
SPS_RS01745	COG1120	ATPase activity
SPS_RS01750	COG4988	ABC transporter
SPS_RS01755	COG1132	(ABC) transporter
SPS_RS01770	COG1129	ABC transporter
SPS_RS01775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPS_RS01790	COG0252	asparaginase activity
SPS_RS01795	COG0561	phosphatase activity
SPS_RS01805	COG0436	Aminotransferase
SPS_RS01815	COG1335	isochorismatase
SPS_RS01845	COG2261	transglycosylase associated protein
SPS_RS01850	COG0588	phosphoglycerate mutase activity
SPS_RS01885	COG1024	Enoyl-CoA hydratase
SPS_RS01910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPS_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
SPS_RS01920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPS_RS01935	COG0439	Biotin carboxylase
SPS_RS01960	COG5433	transposase activity
SPS_RS01970	COG3716	PTS system mannose fructose sorbose family IID component
SPS_RS01975	COG3715	PTS system
SPS_RS01985	COG0561	phosphatase activity
SPS_RS01990	COG2252	PERMEase
SPS_RS01995	COG0802	atpase or kinase
SPS_RS02005	COG1316	TRANSCRIPTIONal
SPS_RS02015	COG0537	adenosine 5'-monophosphoramidase activity
SPS_RS02020	COG1131	(ABC) transporter
SPS_RS02025	COG4473	ABC transporter
SPS_RS02050	COG0195	Participates in both transcription termination and antitermination
SPS_RS02055	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPS_RS02085	COG2217	Heavy metal translocating P-type atpase
SPS_RS02125	COG1105	Belongs to the carbohydrate kinase PfkB family
SPS_RS02135	COG2860	membrane
SPS_RS02140	COG0561	phosphatase activity
SPS_RS02160	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPS_RS02170	COG0656	L-ascorbic acid biosynthetic process
SPS_RS02175	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPS_RS02210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPS_RS02215	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPS_RS02240	COG1131	(ABC) transporter
SPS_RS02350	COG1783	phage Terminase large subunit
SPS_RS02470	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPS_RS02470	COG1388	LysM domain
SPS_RS02515	COG0768	penicillin binding
SPS_RS02525	COG0513	Belongs to the DEAD box helicase family
SPS_RS02535	COG1126	abc transporter atp-binding protein
SPS_RS02545	COG0492	ferredoxin-NADP+ reductase activity
SPS_RS02550	COG1113	amino acid transport
SPS_RS02555	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPS_RS02565	COG3579	cysteine-type endopeptidase activity
SPS_RS02570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPS_RS02590	COG0116	Belongs to the methyltransferase superfamily
SPS_RS02605	COG2610	gluconate transmembrane transporter activity
SPS_RS02620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPS_RS02625	COG0183	Belongs to the thiolase family
SPS_RS02630	COG0583	DNA-binding transcription factor activity
SPS_RS02650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPS_RS02660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPS_RS02660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPS_RS02670	COG2815	serine threonine protein kinase
SPS_RS02670	COG0515	serine threonine protein kinase
SPS_RS02680	COG4585	Histidine kinase
SPS_RS02685	COG2197	response regulator
SPS_RS02695	COG1098	S1 RNA binding domain
SPS_RS02705	COG1739	Uncharacterized protein family UPF0029
SPS_RS03080	COG0383	alpha-mannosidase activity
SPS_RS03090	COG1609	Transcriptional regulator
SPS_RS03095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPS_RS03100	COG2723	6-phospho-beta-galactosidase activity
SPS_RS03105	COG1940	carbohydrate kinase activity
SPS_RS03110	COG1175	transmembrane transport
SPS_RS03115	COG0395	ABC-type sugar transport system, permease component
SPS_RS03120	COG1653	transport
SPS_RS03130	COG2972	Histidine kinase
SPS_RS03135	COG4753	response regulator
SPS_RS03135	COG2207	Transcriptional regulator
SPS_RS03140	COG3250	beta-galactosidase activity
SPS_RS03150	COG2226	methyltransferase
SPS_RS03170	COG1605	Chorismate mutase
SPS_RS03170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPS_RS03210	COG0673	inositol 2-dehydrogenase activity
SPS_RS03220	COG0785	Cytochrome C biogenesis protein
SPS_RS03225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPS_RS03250	COG1396	sequence-specific DNA binding
SPS_RS03260	COG3561	AntA/AntB antirepressor
SPS_RS03285	COG3935	DnaD domain protein
SPS_RS03360	COG1475	DNA binding
SPS_RS03505	COG1388	LysM domain
SPS_RS03505	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPS_RS03545	COG2972	Histidine kinase
SPS_RS03585	COG1288	antiporter activity
SPS_RS03590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPS_RS03595	COG0549	Belongs to the carbamate kinase family
SPS_RS03605	COG0742	ribosomal rna small subunit methyltransferase
SPS_RS03615	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPS_RS03620	COG1609	Transcriptional regulator
SPS_RS03625	COG4470	Protein conserved in bacteria
SPS_RS03640	COG0783	Belongs to the Dps family
SPS_RS03650	COG1940	carbohydrate kinase activity
SPS_RS03655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPS_RS03660	COG1217	gtp-binding protein TYPA
SPS_RS03670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPS_RS03695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPS_RS03710	COG2302	S4 RNA-binding domain
SPS_RS03715	COG3599	regulation of cell shape
SPS_RS03730	COG0494	nUDIX hydrolase
SPS_RS03735	COG0542	response to heat
SPS_RS03740	COG4703	Protein of unknown function (DUF1797)
SPS_RS03745	COG0765	amino acid transport
SPS_RS03755	COG0415	Belongs to the DNA photolyase family
SPS_RS03760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPS_RS03785	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPS_RS03790	COG1438	arginine binding
SPS_RS03795	COG0497	DNA recombination
SPS_RS03810	COG2755	lipolytic protein G-D-S-L family
SPS_RS03825	COG0582	viral genome integration into host DNA
SPS_RS03835	COG1396	sequence-specific DNA binding
SPS_RS03880	COG3723	Recombinational DNA repair protein, rece pathway
SPS_RS04055	COG4824	toxin secretion phage lysis holin
SPS_RS04080	COG2217	Heavy metal translocating P-type atpase
SPS_RS04095	COG1827	regulation of RNA biosynthetic process
SPS_RS04105	COG2116	formate transmembrane transporter activity
SPS_RS04110	COG0768	penicillin binding
SPS_RS04125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPS_RS04140	COG0513	Belongs to the DEAD box helicase family
SPS_RS04155	COG2890	protein-(glutamine-N5) methyltransferase activity
SPS_RS04160	COG0204	Acyl-transferase
SPS_RS04165	COG1596	polysaccharide export
SPS_RS04165	COG1555	photosystem II stabilization
SPS_RS04170	COG2333	competence protein COMEC
SPS_RS04170	COG0658	competence protein
SPS_RS04215	COG1187	pseudouridine synthase activity
SPS_RS04230	COG2223	nitrite transmembrane transporter activity
SPS_RS04235	COG4122	O-methyltransferase activity
SPS_RS04250	COG1476	TRANSCRIPTIONal
SPS_RS04265	COG2801	Transposase and inactivated derivatives
SPS_RS04270	COG2801	Transposase and inactivated derivatives
SPS_RS04285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPS_RS04290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPS_RS04295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPS_RS04315	COG0726	polysaccharide deacetylase
SPS_RS04320	COG0513	Belongs to the DEAD box helicase family
SPS_RS04340	COG1956	GAF domain-containing protein
SPS_RS04345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPS_RS04350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPS_RS04350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPS_RS04380	COG4109	DRTGG domain
SPS_RS04430	COG2814	Major facilitator Superfamily
SPS_RS04440	COG1187	pseudouridine synthase activity
SPS_RS04450	COG2801	Transposase and inactivated derivatives
SPS_RS04465	COG0157	Belongs to the NadC ModD family
SPS_RS04470	COG2801	Transposase and inactivated derivatives
SPS_RS04495	COG2723	6-phospho-beta-galactosidase activity
SPS_RS04505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS_RS04505	COG3711	transcriptional antiterminator
SPS_RS04515	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPS_RS04525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS_RS04530	COG1126	abc transporter atp-binding protein
SPS_RS04535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPS_RS04555	COG1696	Membrane protein involved in D-alanine export
SPS_RS04565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPS_RS04570	COG0657	acetylesterase activity
SPS_RS04585	COG3833	ABC-type maltose transport systems, permease component
SPS_RS04590	COG1175	transmembrane transport
SPS_RS04595	COG2182	Extracellular solute-binding protein
SPS_RS04600	COG1609	Transcriptional regulator
SPS_RS04605	COG1640	4-alpha-glucanotransferase
SPS_RS04610	COG0058	SHG alpha-glucan phosphorylase activity
SPS_RS04795	COG0740	serine-type endopeptidase activity
SPS_RS04890	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPS_RS04920	COG0105	UTP biosynthetic process
SPS_RS04955	COG3715	PTS system
SPS_RS04960	COG3716	PTS system mannose fructose sorbose family IID component
SPS_RS04965	COG2972	Histidine kinase
SPS_RS04970	COG2207	Transcriptional regulator
SPS_RS04970	COG4753	response regulator
SPS_RS04980	COG1012	belongs to the aldehyde dehydrogenase family
SPS_RS04995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPS_RS05025	COG0285	dihydrofolate synthase activity
SPS_RS05060	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPS_RS05065	COG1177	transmembrane transport
SPS_RS05075	COG4565	transcriptional regulatory protein
SPS_RS05080	COG3290	protein histidine kinase activity
SPS_RS05085	COG3493	citrate carrier protein
SPS_RS05100	COG3700	Belongs to the class B bacterial acid phosphatase family
SPS_RS05105	COG0038	chloride channel
SPS_RS05115	COG0628	permease
SPS_RS05125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPS_RS05140	COG1104	cysteine desulfurase activity
SPS_RS05155	COG2357	RelA SpoT domain protein
SPS_RS05165	COG0564	pseudouridine synthase activity
SPS_RS05170	COG0280	phosphate acetyltransferase
SPS_RS05190	COG1174	glycine betaine transport
SPS_RS05205	COG2233	PERMEase
SPS_RS05230	COG2890	protein-(glutamine-N5) methyltransferase activity
SPS_RS05265	COG1132	(ABC) transporter
SPS_RS05285	COG3764	Sortase (surface protein transpeptidase)
SPS_RS05290	COG0346	lactoylglutathione lyase activity
SPS_RS05305	COG1272	protein, Hemolysin III
SPS_RS05325	COG0758	DNA mediated transformation
SPS_RS05330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPS_RS05350	COG0511	ligase activity, forming carbon-carbon bonds
SPS_RS05355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPS_RS05370	COG2851	Citrate transporter
SPS_RS05380	COG0511	ligase activity, forming carbon-carbon bonds
SPS_RS05385	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPS_RS05420	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPS_RS05440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPS_RS05450	COG2188	Transcriptional regulator
SPS_RS05470	COG0488	(ABC) transporter
SPS_RS05480	COG0352	thiamine-phosphate diphosphorylase activity
SPS_RS05480	COG0351	phosphomethylpyrimidine kinase
SPS_RS05485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPS_RS05490	COG1328	CTP reductase activity
SPS_RS05490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPS_RS05495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPS_RS05525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPS_RS05545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPS_RS05550	COG4684	Psort location CytoplasmicMembrane, score
SPS_RS05555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPS_RS05560	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPS_RS05565	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPS_RS05570	COG3845	ABC transporter
SPS_RS05575	COG1744	ABC transporter substrate-binding protein PnrA-like
SPS_RS05580	COG0295	cytidine deaminase activity
SPS_RS05585	COG2813	Specifically methylates the guanine in position
SPS_RS05600	COG5002	protein histidine kinase activity
SPS_RS05605	COG0745	RESPONSE REGULATOR receiver
SPS_RS05615	COG0704	Plays a role in the regulation of phosphate uptake
SPS_RS05630	COG0581	inorganic phosphate transmembrane transporter activity
SPS_RS05635	COG0573	inorganic phosphate transmembrane transporter activity
SPS_RS05645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPS_RS05645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPS_RS05650	COG0483	inositol monophosphate 1-phosphatase activity
SPS_RS05665	COG0196	riboflavin kinase activity
SPS_RS05695	COG1136	(ABC) transporter
SPS_RS05695	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPS_RS05745	COG1115	amino acid carrier protein
SPS_RS05750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPS_RS05760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPS_RS05765	COG1126	abc transporter atp-binding protein
SPS_RS05770	COG0765	amino acid transport
SPS_RS05775	COG2824	Alkylphosphonate utilization operon protein PhnA
SPS_RS05790	COG0469	pyruvate kinase activity
SPS_RS05805	COG1725	Transcriptional regulator
SPS_RS05810	COG1131	(ABC) transporter
SPS_RS05835	COG3177	Filamentation induced by cAMP protein fic
SPS_RS05840	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPS_RS05840	COG1388	LysM domain
SPS_RS05935	COG0740	serine-type endopeptidase activity
SPS_RS05980	COG0582	viral genome integration into host DNA
SPS_RS06040	COG1484	DNA-dependent DNA replication
SPS_RS06050	COG0305	Participates in initiation and elongation during chromosome replication
SPS_RS06115	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SPS_RS06120	COG1518	maintenance of DNA repeat elements
SPS_RS06135	COG0647	UMP catabolic process
SPS_RS06145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPS_RS06165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPS_RS06170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPS_RS06175	COG3442	glutamine amidotransferase
SPS_RS06180	COG0095	Lipoate-protein ligase
SPS_RS06185	COG5492	domain, Protein
SPS_RS06200	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPS_RS06205	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPS_RS06205	COG0022	dehydrogenase e1 component
SPS_RS06210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPS_RS06215	COG0488	(ABC) transporter
SPS_RS06235	COG1129	ABC transporter
SPS_RS06255	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPS_RS06260	COG0457	Tetratricopeptide repeat
SPS_RS06265	COG0628	permease
SPS_RS06270	COG1051	belongs to the nudix hydrolase family
SPS_RS06275	COG1088	dTDP-glucose 4,6-dehydratase activity
SPS_RS06285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPS_RS06290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPS_RS06300	COG2384	SAM-dependent methyltransferase
SPS_RS06305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPS_RS06320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPS_RS06320	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPS_RS06325	COG0300	oxidoreductase activity
SPS_RS06335	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPS_RS06340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPS_RS06375	COG0539	negative regulation of cytoplasmic translation
SPS_RS06395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPS_RS06405	COG0187	DNA topoisomerase II activity
SPS_RS06425	COG0765	amino acid transport
SPS_RS06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPS_RS06455	COG0583	DNA-binding transcription factor activity
SPS_RS06515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPS_RS06525	COG3425	synthase
SPS_RS06560	COG0745	RESPONSE REGULATOR receiver
SPS_RS06565	COG2357	RelA SpoT domain protein
SPS_RS06570	COG0737	Belongs to the 5'-nucleotidase family
SPS_RS06575	COG0242	peptide deformylase activity
SPS_RS06585	COG0488	(ABC) transporter
SPS_RS06605	COG0105	UTP biosynthetic process
SPS_RS06620	COG1388	LysM domain
SPS_RS06620	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPS_RS06625	COG1388	LysM domain
SPS_RS06625	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPS_RS06630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS_RS06630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPS_RS06630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPS_RS06635	COG1105	Belongs to the carbohydrate kinase PfkB family
SPS_RS06640	COG1349	DNA-binding transcription factor activity
SPS_RS06690	COG1837	Belongs to the UPF0109 family
SPS_RS06700	COG0584	glycerophosphoryl diester phosphodiesterase
SPS_RS06705	COG0577	efflux transmembrane transporter activity
SPS_RS06710	COG1136	(ABC) transporter
SPS_RS06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPS_RS06745	COG0564	pseudouridine synthase activity
SPS_RS06755	COG0583	DNA-binding transcription factor activity
SPS_RS06760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPS_RS06785	COG1104	cysteine desulfurase activity
SPS_RS06795	COG0285	dihydrofolate synthase activity
SPS_RS06800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPS_RS06820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPS_RS06825	COG1368	sulfuric ester hydrolase activity
SPS_RS06880	COG1216	Glycosyl transferase, family 2
SPS_RS06925	COG2151	metal-sulfur cluster biosynthetic enzyme
SPS_RS06930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPS_RS06935	COG0358	DNA primase activity
SPS_RS06940	COG1970	mechanosensitive ion channel activity
SPS_RS06950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPS_RS06975	COG0577	efflux transmembrane transporter activity
SPS_RS07060	COG1597	lipid kinase activity
SPS_RS07070	COG4708	membrane
SPS_RS07090	COG1131	(ABC) transporter
SPS_RS07160	COG0038	chloride channel
SPS_RS07170	COG0716	FMN binding
SPS_RS07175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPS_RS07185	COG2222	sugar isomerase
SPS_RS07190	COG2188	Transcriptional regulator
SPS_RS07225	COG0436	Aminotransferase
SPS_RS07230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPS_RS07230	COG1199	ATP-dependent helicase activity
SPS_RS07245	COG2177	Part of the ABC transporter FtsEX involved in
SPS_RS07250	COG2884	Cell division ATP-binding protein ftsE
SPS_RS07260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPS_RS07265	COG0546	phosphoglycolate phosphatase activity
SPS_RS07270	COG0800	Aldolase
SPS_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
SPS_RS07300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS_RS07305	COG3715	PTS system
SPS_RS07310	COG3716	PTS system mannose fructose sorbose family IID component
SPS_RS07320	COG1609	Transcriptional regulator
SPS_RS07335	COG1078	dGTPase activity
SPS_RS07370	COG0772	Belongs to the SEDS family
SPS_RS07380	COG1164	Oligoendopeptidase f
SPS_RS07385	COG0386	Belongs to the glutathione peroxidase family
SPS_RS07435	COG4443	Transcriptional Coactivator p15 (PC4)
SPS_RS07440	COG0826	peptidase U32
SPS_RS07485	COG2183	response to ionizing radiation
SPS_RS07495	COG0701	Predicted permease
SPS_RS07500	COG3689	TIGRFAM TIGR03943 family protein
SPS_RS07510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS_RS07510	COG1263	PTS System
SPS_RS07510	COG2190	(PTS) system
SPS_RS07515	COG3711	transcriptional antiterminator
SPS_RS07520	COG0477	Major facilitator Superfamily
SPS_RS07525	COG0552	protein localization to endoplasmic reticulum
SPS_RS07530	COG0561	phosphatase activity
SPS_RS07535	COG0561	phosphatase activity
SPS_RS07645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPS_RS07655	COG1196	nuclear chromosome segregation
SPS_RS07665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPS_RS07670	COG5002	protein histidine kinase activity
SPS_RS07675	COG0745	RESPONSE REGULATOR receiver
SPS_RS07690	COG0183	Belongs to the thiolase family
SPS_RS07710	COG4555	ABC transporter
SPS_RS07720	COG0438	transferase activity, transferring glycosyl groups
SPS_RS07730	COG1609	Transcriptional regulator
SPS_RS07735	COG0006	proline dipeptidase activity
SPS_RS07740	COG0778	Nitroreductase
SPS_RS07750	COG0463	Glycosyl transferase, family 2
SPS_RS07780	COG0557	exoribonuclease II activity
SPS_RS07790	COG2814	Major facilitator Superfamily
SPS_RS07795	COG0433	COG0433 Predicted ATPase
SPS_RS07875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPS_RS07885	COG1573	uracil-dna glycosylase
SPS_RS07890	COG1702	phosphate starvation-inducible protein PhoH
SPS_RS07980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPS_RS07990	COG0494	nUDIX hydrolase
SPS_RS08005	COG0673	inositol 2-dehydrogenase activity
SPS_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
SPS_RS08070	COG1304	FMN binding
SPS_RS08080	COG0708	Exodeoxyribonuclease III
SPS_RS08085	COG1393	Belongs to the ArsC family
SPS_RS08120	COG0470	DNA polymerase III
SPS_RS08145	COG2244	polysaccharide biosynthetic process
SPS_RS08155	COG1120	ATPase activity
SPS_RS08160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPS_RS08165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS_RS08170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS_RS08185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPS_RS08190	COG1253	flavin adenine dinucleotide binding
SPS_RS08195	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPS_RS08200	COG1242	4 iron, 4 sulfur cluster binding
SPS_RS08205	COG0671	phosphoesterase, PA-phosphatase related
SPS_RS08210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPS_RS08225	COG1187	pseudouridine synthase activity
SPS_RS08280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPS_RS08285	COG1254	Belongs to the acylphosphatase family
SPS_RS08300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPS_RS08320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPS_RS08330	COG1484	DNA-dependent DNA replication
SPS_RS08350	COG0745	RESPONSE REGULATOR receiver
SPS_RS08365	COG1704	LemA family
SPS_RS08375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPS_RS08380	COG0569	domain protein
SPS_RS08390	COG1114	Component of the transport system for branched-chain amino acids
SPS_RS08405	COG1464	Belongs to the NlpA lipoprotein family
SPS_RS08410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPS_RS08425	COG2226	methyltransferase
SPS_RS08430	COG0799	negative regulation of ribosome biogenesis
SPS_RS08435	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPS_RS08445	COG1534	Rna-binding protein
SPS_RS08450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPS_RS08455	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPS_RS08465	COG5433	transposase activity
SPS_RS08505	COG1929	Belongs to the glycerate kinase type-1 family
SPS_RS08510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPS_RS08535	COG0577	efflux transmembrane transporter activity
SPS_RS08540	COG1136	(ABC) transporter
SPS_RS08570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS_RS08570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS_RS08575	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPS_RS08625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPS_RS08630	COG1476	TRANSCRIPTIONal
SPS_RS08660	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPS_RS08675	COG1045	serine acetyltransferase
SPS_RS08690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPS_RS08705	COG3711	transcriptional antiterminator
SPS_RS08730	COG0431	NADPH-dependent FMN reductase
SPS_RS08735	COG1846	Transcriptional regulator
SPS_RS08755	COG4589	Belongs to the CDS family
SPS_RS08765	COG1862	Preprotein translocase
SPS_RS08775	COG1523	belongs to the glycosyl hydrolase 13 family
SPS_RS08785	COG3842	ATPase activity
SPS_RS08820	COG5433	transposase activity
SPS_RS08835	COG1263	PTS System
SPS_RS08835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS_RS08835	COG2190	(PTS) system
SPS_RS08840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPS_RS08855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPS_RS08860	COG0512	Glutamine amidotransferase of anthranilate synthase
SPS_RS08865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPS_RS08890	COG0601	transmembrane transport
SPS_RS08920	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPS_RS08930	COG1196	nuclear chromosome segregation
SPS_RS08935	COG3711	transcriptional antiterminator
SPS_RS08945	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPS_RS08945	COG3942	CHAP domain
SPS_RS08950	COG2205	protein histidine kinase activity
SPS_RS08955	COG0745	RESPONSE REGULATOR receiver
SPS_RS08960	COG0577	efflux transmembrane transporter activity
SPS_RS08965	COG1136	(ABC) transporter
SPS_RS09015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPS_RS09030	COG1882	Formate acetyltransferase
SPS_RS09035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS_RS09040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS_RS09045	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPS_RS09050	COG2390	Transcriptional regulator
SPS_RS09055	COG1349	DNA-binding transcription factor activity
SPS_RS09060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPS_RS09075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPS_RS09090	COG0564	pseudouridine synthase activity
SPS_RS09125	COG0542	response to heat
SPS_RS09130	COG4463	regulation of RNA biosynthetic process
SPS_RS09145	COG0450	alkyl hydroperoxide reductase
SPS_RS09160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPS_RS09170	COG3404	Formiminotransferase-cyclodeaminase
SPS_RS09185	COG0531	amino acid
SPS_RS09215	COG3590	peptidase
SPS_RS09220	COG0366	Alpha amylase catalytic
SPS_RS09225	COG1263	PTS System
SPS_RS09225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS_RS09230	COG2188	Transcriptional regulator
SPS_RS09240	COG2514	catechol 2,3-dioxygenase activity
SPS_RS09250	COG0602	queuosine metabolic process
SPS_RS09265	COG1328	CTP reductase activity
SPS_RS09290	COG1393	Belongs to the ArsC family
SPS_RS09305	COG0519	Catalyzes the synthesis of GMP from XMP
SPS_RS09350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPS_RS09355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPS_RS09360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPS_RS09440	COG1511	domain protein
SPS_RS09460	COG0305	Participates in initiation and elongation during chromosome replication
SPS_RS09490	COG1760	l-serine dehydratase
SPS_RS09495	COG1760	l-serine dehydratase
SPS_RS09500	COG0741	lytic transglycosylase activity
SPS_RS09505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPS_RS09520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPS_RS09530	COG0612	Peptidase, M16
SPS_RS09585	COG0488	(ABC) transporter
SPS_RS09620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPS_RS09625	COG1475	DNA binding