locus-tag	class	description
B4W66_RS00010	COG0592	DNA-directed DNA polymerase activity
B4W66_RS00020	COG0012	GTP binding
B4W66_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4W66_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4W66_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4W66_RS00065	COG0531	amino acid
B4W66_RS00175	COG3942	CHAP domain
B4W66_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4W66_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4W66_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4W66_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4W66_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4W66_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4W66_RS00285	COG1012	belongs to the aldehyde dehydrogenase family
B4W66_RS00285	COG1454	alcohol dehydrogenase
B4W66_RS00290	COG1064	alcohol dehydrogenase
B4W66_RS00295	COG0534	Mate efflux family protein
B4W66_RS00405	COG0201	protein transport
B4W66_RS00525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B4W66_RS00550	COG1121	(ABC) transporter
B4W66_RS00555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4W66_RS00570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4W66_RS00590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4W66_RS00595	COG1459	type II secretion system
B4W66_RS00600	COG4537	Required for transformation and DNA binding
B4W66_RS00640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4W66_RS00645	COG1363	Peptidase, m42
B4W66_RS00660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4W66_RS00665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4W66_RS00680	COG1428	Deoxynucleoside kinase
B4W66_RS00685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4W66_RS00745	COG2031	fatty acid transporter
B4W66_RS00760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4W66_RS00775	COG0251	oxidation-reduction process
B4W66_RS00790	COG1269	ATP hydrolysis coupled proton transport
B4W66_RS00795	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4W66_RS00805	COG1527	subunit (C
B4W66_RS00810	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
B4W66_RS00845	COG1744	ABC transporter substrate-binding protein PnrA-like
B4W66_RS00885	COG0626	cystathionine gamma-synthase activity
B4W66_RS00915	COG3623	hexulose-6-phosphate isomerase
B4W66_RS00940	COG4175	Glycine betaine
B4W66_RS00940	COG3448	diguanylate cyclase activity
B4W66_RS00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4W66_RS00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4W66_RS00970	COG3969	phosphoadenosine phosphosulfate
B4W66_RS00975	COG1475	DNA binding
B4W66_RS00985	COG2801	Transposase and inactivated derivatives
B4W66_RS01000	COG0157	Belongs to the NadC ModD family
B4W66_RS01030	COG1268	BioY protein
B4W66_RS01035	COG1234	tRNA 3'-trailer cleavage
B4W66_RS01070	COG0457	Tetratricopeptide repeat
B4W66_RS01070	COG0705	Rhomboid family
B4W66_RS01090	COG1132	(ABC) transporter
B4W66_RS01095	COG1132	(ABC) transporter
B4W66_RS01105	COG0756	dUTP diphosphatase activity
B4W66_RS01130	COG3290	protein histidine kinase activity
B4W66_RS01155	COG1847	R3H domain protein
B4W66_RS01175	COG1175	transmembrane transport
B4W66_RS01180	COG0395	ABC-type sugar transport system, permease component
B4W66_RS01190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4W66_RS01205	COG0084	hydrolase, TatD family'
B4W66_RS01230	COG1564	THIamine pyrophosphokinase
B4W66_RS01245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4W66_RS01285	COG0765	amino acid transport
B4W66_RS01305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4W66_RS01315	COG0719	Fe-S assembly protein
B4W66_RS01320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4W66_RS01335	COG1686	Belongs to the peptidase S11 family
B4W66_RS01340	COG1686	Belongs to the peptidase S11 family
B4W66_RS01345	COG4166	transmembrane transport
B4W66_RS01350	COG0601	transmembrane transport
B4W66_RS01355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4W66_RS01360	COG0444	Belongs to the ABC transporter superfamily
B4W66_RS01370	COG2801	Transposase and inactivated derivatives
B4W66_RS01380	COG2801	Transposase and inactivated derivatives
B4W66_RS01425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4W66_RS01430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4W66_RS01435	COG1534	Rna-binding protein
B4W66_RS01445	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4W66_RS01450	COG0799	negative regulation of ribosome biogenesis
B4W66_RS01455	COG2226	methyltransferase
B4W66_RS01475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4W66_RS01480	COG1464	Belongs to the NlpA lipoprotein family
B4W66_RS01495	COG1114	Component of the transport system for branched-chain amino acids
B4W66_RS01505	COG0569	domain protein
B4W66_RS01510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4W66_RS01520	COG1704	LemA family
B4W66_RS01535	COG0745	RESPONSE REGULATOR receiver
B4W66_RS01540	COG5002	protein histidine kinase activity
B4W66_RS01555	COG1484	DNA-dependent DNA replication
B4W66_RS01565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4W66_RS01585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4W66_RS01600	COG1254	Belongs to the acylphosphatase family
B4W66_RS01605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4W66_RS01660	COG1187	pseudouridine synthase activity
B4W66_RS01675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4W66_RS01680	COG0671	phosphoesterase, PA-phosphatase related
B4W66_RS01685	COG1242	4 iron, 4 sulfur cluster binding
B4W66_RS01690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4W66_RS01695	COG1253	flavin adenine dinucleotide binding
B4W66_RS01700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B4W66_RS01715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4W66_RS01720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4W66_RS01725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4W66_RS01730	COG1120	ATPase activity
B4W66_RS01740	COG2244	polysaccharide biosynthetic process
B4W66_RS01770	COG0470	DNA polymerase III
B4W66_RS01800	COG1393	Belongs to the ArsC family
B4W66_RS01815	COG1609	Transcriptional regulator
B4W66_RS01820	COG0561	phosphatase activity
B4W66_RS01825	COG0708	Exodeoxyribonuclease III
B4W66_RS01835	COG1304	FMN binding
B4W66_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
B4W66_RS01935	COG0673	inositol 2-dehydrogenase activity
B4W66_RS01950	COG0494	nUDIX hydrolase
B4W66_RS01960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4W66_RS02050	COG1702	phosphate starvation-inducible protein PhoH
B4W66_RS02055	COG1573	uracil-dna glycosylase
B4W66_RS02065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4W66_RS02160	COG0433	COG0433 Predicted ATPase
B4W66_RS02165	COG2814	Major facilitator Superfamily
B4W66_RS02180	COG0557	exoribonuclease II activity
B4W66_RS02210	COG0463	Glycosyl transferase, family 2
B4W66_RS02220	COG0778	Nitroreductase
B4W66_RS02225	COG0006	proline dipeptidase activity
B4W66_RS02230	COG1609	Transcriptional regulator
B4W66_RS02240	COG0438	transferase activity, transferring glycosyl groups
B4W66_RS02250	COG4555	ABC transporter
B4W66_RS02270	COG0183	Belongs to the thiolase family
B4W66_RS02285	COG0745	RESPONSE REGULATOR receiver
B4W66_RS02290	COG5002	protein histidine kinase activity
B4W66_RS02295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4W66_RS02305	COG1196	nuclear chromosome segregation
B4W66_RS02315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4W66_RS02415	COG0561	phosphatase activity
B4W66_RS02420	COG0561	phosphatase activity
B4W66_RS02425	COG0552	protein localization to endoplasmic reticulum
B4W66_RS02430	COG0477	Major facilitator Superfamily
B4W66_RS02435	COG3711	transcriptional antiterminator
B4W66_RS02440	COG2190	(PTS) system
B4W66_RS02440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4W66_RS02440	COG1263	PTS System
B4W66_RS02450	COG3689	TIGRFAM TIGR03943 family protein
B4W66_RS02455	COG0701	Predicted permease
B4W66_RS02465	COG2183	response to ionizing radiation
B4W66_RS02510	COG0826	peptidase U32
B4W66_RS02515	COG4443	Transcriptional Coactivator p15 (PC4)
B4W66_RS02545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4W66_RS02570	COG0386	Belongs to the glutathione peroxidase family
B4W66_RS02575	COG1164	Oligoendopeptidase f
B4W66_RS02585	COG0772	Belongs to the SEDS family
B4W66_RS02620	COG1078	dGTPase activity
B4W66_RS02635	COG1609	Transcriptional regulator
B4W66_RS02645	COG3716	PTS system mannose fructose sorbose family IID component
B4W66_RS02650	COG3715	PTS system
B4W66_RS02655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4W66_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
B4W66_RS02685	COG0800	Aldolase
B4W66_RS02690	COG0546	phosphoglycolate phosphatase activity
B4W66_RS02695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4W66_RS02705	COG2884	Cell division ATP-binding protein ftsE
B4W66_RS02710	COG2177	Part of the ABC transporter FtsEX involved in
B4W66_RS02725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4W66_RS02725	COG1199	ATP-dependent helicase activity
B4W66_RS02730	COG0436	Aminotransferase
B4W66_RS02765	COG2188	Transcriptional regulator
B4W66_RS02770	COG2222	sugar isomerase
B4W66_RS02780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4W66_RS02785	COG0716	FMN binding
B4W66_RS02795	COG0038	chloride channel
B4W66_RS02870	COG1131	(ABC) transporter
B4W66_RS02895	COG4708	membrane
B4W66_RS02905	COG1597	lipid kinase activity
B4W66_RS02990	COG0577	efflux transmembrane transporter activity
B4W66_RS03000	COG2321	neutral zinc metallopeptidase
B4W66_RS03015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4W66_RS03025	COG1970	mechanosensitive ion channel activity
B4W66_RS03030	COG0358	DNA primase activity
B4W66_RS03035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4W66_RS03040	COG2151	metal-sulfur cluster biosynthetic enzyme
B4W66_RS03085	COG1216	Glycosyl transferase, family 2
B4W66_RS03145	COG1368	sulfuric ester hydrolase activity
B4W66_RS03150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4W66_RS03170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4W66_RS03175	COG0285	dihydrofolate synthase activity
B4W66_RS03185	COG1104	cysteine desulfurase activity
B4W66_RS03210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4W66_RS03220	COG0583	DNA-binding transcription factor activity
B4W66_RS03230	COG0564	pseudouridine synthase activity
B4W66_RS03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4W66_RS03280	COG1136	(ABC) transporter
B4W66_RS03285	COG0577	efflux transmembrane transporter activity
B4W66_RS03290	COG0584	glycerophosphoryl diester phosphodiesterase
B4W66_RS03300	COG1837	Belongs to the UPF0109 family
B4W66_RS03350	COG1349	DNA-binding transcription factor activity
B4W66_RS03355	COG1105	Belongs to the carbohydrate kinase PfkB family
B4W66_RS03360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4W66_RS03360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4W66_RS03360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4W66_RS03365	COG3942	CHAP domain
B4W66_RS03365	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4W66_RS03370	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4W66_RS03370	COG1388	LysM domain
B4W66_RS03410	COG0488	(ABC) transporter
B4W66_RS03425	COG0242	peptide deformylase activity
B4W66_RS03430	COG0737	Belongs to the 5'-nucleotidase family
B4W66_RS03435	COG2357	RelA SpoT domain protein
B4W66_RS03440	COG0745	RESPONSE REGULATOR receiver
B4W66_RS03475	COG3425	synthase
B4W66_RS03485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4W66_RS03545	COG0583	DNA-binding transcription factor activity
B4W66_RS03570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4W66_RS03575	COG0765	amino acid transport
B4W66_RS03595	COG0187	DNA topoisomerase II activity
B4W66_RS03605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4W66_RS03625	COG0539	negative regulation of cytoplasmic translation
B4W66_RS03670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4W66_RS03675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B4W66_RS03685	COG0300	oxidoreductase activity
B4W66_RS03690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4W66_RS03690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4W66_RS03705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4W66_RS03710	COG2384	SAM-dependent methyltransferase
B4W66_RS03720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4W66_RS03725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B4W66_RS03735	COG1088	dTDP-glucose 4,6-dehydratase activity
B4W66_RS03740	COG0582	viral genome integration into host DNA
B4W66_RS03855	COG1783	phage Terminase large subunit
B4W66_RS04000	COG1051	belongs to the nudix hydrolase family
B4W66_RS04005	COG0628	permease
B4W66_RS04010	COG0457	Tetratricopeptide repeat
B4W66_RS04015	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B4W66_RS04035	COG1129	ABC transporter
B4W66_RS04055	COG0488	(ABC) transporter
B4W66_RS04060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4W66_RS04065	COG0022	dehydrogenase e1 component
B4W66_RS04065	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4W66_RS04070	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4W66_RS04085	COG1695	Transcriptional regulator
B4W66_RS04095	COG0095	Lipoate-protein ligase
B4W66_RS04100	COG3442	glutamine amidotransferase
B4W66_RS04105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4W66_RS04110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4W66_RS04130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4W66_RS04140	COG0647	UMP catabolic process
B4W66_RS04155	COG0105	UTP biosynthetic process
B4W66_RS04190	COG3715	PTS system
B4W66_RS04195	COG3716	PTS system mannose fructose sorbose family IID component
B4W66_RS04200	COG2972	Histidine kinase
B4W66_RS04205	COG2207	Transcriptional regulator
B4W66_RS04205	COG4753	response regulator
B4W66_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
B4W66_RS04230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4W66_RS04310	COG1131	(ABC) transporter
B4W66_RS04355	COG0285	dihydrofolate synthase activity
B4W66_RS04375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4W66_RS04390	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4W66_RS04395	COG1177	transmembrane transport
B4W66_RS04405	COG4565	transcriptional regulatory protein
B4W66_RS04410	COG3290	protein histidine kinase activity
B4W66_RS04415	COG3493	citrate carrier protein
B4W66_RS04430	COG3700	Belongs to the class B bacterial acid phosphatase family
B4W66_RS04435	COG0038	chloride channel
B4W66_RS04445	COG0628	permease
B4W66_RS04455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B4W66_RS04470	COG1104	cysteine desulfurase activity
B4W66_RS04485	COG2357	RelA SpoT domain protein
B4W66_RS04495	COG0564	pseudouridine synthase activity
B4W66_RS04500	COG0280	phosphate acetyltransferase
B4W66_RS04505	COG4221	oxidoreductase activity
B4W66_RS04520	COG1174	glycine betaine transport
B4W66_RS04540	COG2233	PERMEase
B4W66_RS04565	COG2890	protein-(glutamine-N5) methyltransferase activity
B4W66_RS04595	COG1132	(ABC) transporter
B4W66_RS04600	COG1132	(ABC) transporter
B4W66_RS04620	COG3764	Sortase (surface protein transpeptidase)
B4W66_RS04625	COG0346	lactoylglutathione lyase activity
B4W66_RS04645	COG1272	protein, Hemolysin III
B4W66_RS04665	COG0758	DNA mediated transformation
B4W66_RS04670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4W66_RS04720	COG0511	ligase activity, forming carbon-carbon bonds
B4W66_RS04725	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B4W66_RS04740	COG2851	Citrate transporter
B4W66_RS04750	COG0511	ligase activity, forming carbon-carbon bonds
B4W66_RS04755	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B4W66_RS04790	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
B4W66_RS04810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4W66_RS04820	COG2188	Transcriptional regulator
B4W66_RS04840	COG0488	(ABC) transporter
B4W66_RS04850	COG0352	thiamine-phosphate diphosphorylase activity
B4W66_RS04850	COG0351	phosphomethylpyrimidine kinase
B4W66_RS04855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4W66_RS04865	COG1328	CTP reductase activity
B4W66_RS04865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4W66_RS04870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4W66_RS04900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4W66_RS04910	COG0095	Lipoate-protein ligase
B4W66_RS04920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4W66_RS04925	COG4684	Psort location CytoplasmicMembrane, score
B4W66_RS04930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4W66_RS04935	COG1079	Belongs to the binding-protein-dependent transport system permease family
B4W66_RS04940	COG4603	Belongs to the binding-protein-dependent transport system permease family
B4W66_RS04945	COG3845	ABC transporter
B4W66_RS04950	COG1744	ABC transporter substrate-binding protein PnrA-like
B4W66_RS04955	COG0295	cytidine deaminase activity
B4W66_RS04960	COG2813	Specifically methylates the guanine in position
B4W66_RS04975	COG5002	protein histidine kinase activity
B4W66_RS04980	COG0745	RESPONSE REGULATOR receiver
B4W66_RS04990	COG0704	Plays a role in the regulation of phosphate uptake
B4W66_RS05005	COG0581	inorganic phosphate transmembrane transporter activity
B4W66_RS05010	COG0573	inorganic phosphate transmembrane transporter activity
B4W66_RS05020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4W66_RS05020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B4W66_RS05025	COG0483	inositol monophosphate 1-phosphatase activity
B4W66_RS05040	COG0196	riboflavin kinase activity
B4W66_RS05070	COG4591	ABC-type transport system involved in lipoprotein release permease component
B4W66_RS05070	COG1136	(ABC) transporter
B4W66_RS05120	COG1115	amino acid carrier protein
B4W66_RS05125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4W66_RS05135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4W66_RS05140	COG1126	abc transporter atp-binding protein
B4W66_RS05145	COG0765	amino acid transport
B4W66_RS05150	COG2824	Alkylphosphonate utilization operon protein PhnA
B4W66_RS05165	COG0469	pyruvate kinase activity
B4W66_RS05180	COG1725	Transcriptional regulator
B4W66_RS05185	COG1131	(ABC) transporter
B4W66_RS05210	COG0058	SHG alpha-glucan phosphorylase activity
B4W66_RS05215	COG1640	4-alpha-glucanotransferase
B4W66_RS05220	COG1609	Transcriptional regulator
B4W66_RS05225	COG2182	Extracellular solute-binding protein
B4W66_RS05230	COG1175	transmembrane transport
B4W66_RS05235	COG3833	ABC-type maltose transport systems, permease component
B4W66_RS05250	COG3833	ABC-type maltose transport systems, permease component
B4W66_RS05255	COG1175	transmembrane transport
B4W66_RS05265	COG0366	Alpha amylase catalytic
B4W66_RS05270	COG2182	Extracellular solute-binding protein
B4W66_RS05280	COG0657	acetylesterase activity
B4W66_RS05285	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4W66_RS05295	COG1696	Membrane protein involved in D-alanine export
B4W66_RS05315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4W66_RS05320	COG1126	abc transporter atp-binding protein
B4W66_RS05325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4W66_RS05335	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4W66_RS05345	COG3711	transcriptional antiterminator
B4W66_RS05345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4W66_RS05355	COG2723	6-phospho-beta-galactosidase activity
B4W66_RS05385	COG1187	pseudouridine synthase activity
B4W66_RS05395	COG2814	Major facilitator Superfamily
B4W66_RS05445	COG4109	DRTGG domain
B4W66_RS05450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4W66_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
B4W66_RS05495	COG0800	Aldolase
B4W66_RS05500	COG2186	Transcriptional regulator
B4W66_RS05505	COG3250	beta-galactosidase activity
B4W66_RS05515	COG2211	Major facilitator Superfamily
B4W66_RS05535	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4W66_RS05535	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4W66_RS05545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4W66_RS05550	COG1956	GAF domain-containing protein
B4W66_RS05570	COG0513	Belongs to the DEAD box helicase family
B4W66_RS05575	COG0726	polysaccharide deacetylase
B4W66_RS05595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4W66_RS05600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4W66_RS05630	COG1476	TRANSCRIPTIONal
B4W66_RS05645	COG4122	O-methyltransferase activity
B4W66_RS05650	COG2223	nitrite transmembrane transporter activity
B4W66_RS05665	COG1187	pseudouridine synthase activity
B4W66_RS05705	COG0658	competence protein
B4W66_RS05705	COG2333	competence protein COMEC
B4W66_RS05710	COG1596	polysaccharide export
B4W66_RS05710	COG1555	photosystem II stabilization
B4W66_RS05715	COG0204	Acyl-transferase
B4W66_RS05720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4W66_RS05735	COG0513	Belongs to the DEAD box helicase family
B4W66_RS05755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4W66_RS05770	COG0768	penicillin binding
B4W66_RS05775	COG2116	formate transmembrane transporter activity
B4W66_RS05785	COG1827	regulation of RNA biosynthetic process
B4W66_RS05800	COG2217	Heavy metal translocating P-type atpase
B4W66_RS05830	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4W66_RS05830	COG1388	LysM domain
B4W66_RS05840	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4W66_RS06090	COG0582	viral genome integration into host DNA
B4W66_RS06105	COG2755	lipolytic protein G-D-S-L family
B4W66_RS06120	COG0497	DNA recombination
B4W66_RS06125	COG1438	arginine binding
B4W66_RS06130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4W66_RS06155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4W66_RS06160	COG0415	Belongs to the DNA photolyase family
B4W66_RS06170	COG0765	amino acid transport
B4W66_RS06175	COG4703	Protein of unknown function (DUF1797)
B4W66_RS06180	COG0542	response to heat
B4W66_RS06185	COG0494	nUDIX hydrolase
B4W66_RS06200	COG3599	regulation of cell shape
B4W66_RS06205	COG2302	S4 RNA-binding domain
B4W66_RS06220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4W66_RS06255	COG1217	gtp-binding protein TYPA
B4W66_RS06260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4W66_RS06265	COG1940	carbohydrate kinase activity
B4W66_RS06275	COG0783	Belongs to the Dps family
B4W66_RS06290	COG4470	Protein conserved in bacteria
B4W66_RS06295	COG1609	Transcriptional regulator
B4W66_RS06300	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4W66_RS06310	COG0742	ribosomal rna small subunit methyltransferase
B4W66_RS06320	COG0549	Belongs to the carbamate kinase family
B4W66_RS06325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4W66_RS06330	COG1288	antiporter activity
B4W66_RS06345	COG2235	arginine
B4W66_RS06370	COG2972	Histidine kinase
B4W66_RS06385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4W66_RS06390	COG0785	Cytochrome C biogenesis protein
B4W66_RS06395	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B4W66_RS06400	COG1518	maintenance of DNA repeat elements
B4W66_RS06465	COG1605	Chorismate mutase
B4W66_RS06465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4W66_RS06485	COG2226	methyltransferase
B4W66_RS06495	COG3250	beta-galactosidase activity
B4W66_RS06500	COG2207	Transcriptional regulator
B4W66_RS06500	COG4753	response regulator
B4W66_RS06505	COG2972	Histidine kinase
B4W66_RS06515	COG1653	transport
B4W66_RS06520	COG0395	ABC-type sugar transport system, permease component
B4W66_RS06525	COG1175	transmembrane transport
B4W66_RS06530	COG1940	carbohydrate kinase activity
B4W66_RS06535	COG2723	6-phospho-beta-galactosidase activity
B4W66_RS06540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B4W66_RS06555	COG0383	alpha-mannosidase activity
B4W66_RS06660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4W66_RS06665	COG1739	Uncharacterized protein family UPF0029
B4W66_RS06675	COG1098	S1 RNA binding domain
B4W66_RS06685	COG2197	response regulator
B4W66_RS06690	COG4585	Histidine kinase
B4W66_RS06700	COG2815	serine threonine protein kinase
B4W66_RS06700	COG0515	serine threonine protein kinase
B4W66_RS06710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4W66_RS06710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4W66_RS06720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4W66_RS06740	COG0583	DNA-binding transcription factor activity
B4W66_RS06745	COG0183	Belongs to the thiolase family
B4W66_RS06750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4W66_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
B4W66_RS06765	COG2610	gluconate transmembrane transporter activity
B4W66_RS06780	COG0116	Belongs to the methyltransferase superfamily
B4W66_RS06805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4W66_RS06810	COG3579	cysteine-type endopeptidase activity
B4W66_RS06820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4W66_RS06825	COG1113	amino acid transport
B4W66_RS06830	COG0492	ferredoxin-NADP+ reductase activity
B4W66_RS06840	COG1126	abc transporter atp-binding protein
B4W66_RS06850	COG0513	Belongs to the DEAD box helicase family
B4W66_RS06860	COG0768	penicillin binding
B4W66_RS06895	COG1131	(ABC) transporter
B4W66_RS06920	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4W66_RS06925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4W66_RS06965	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4W66_RS06980	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4W66_RS07000	COG0561	phosphatase activity
B4W66_RS07005	COG2860	membrane
B4W66_RS07065	COG2217	Heavy metal translocating P-type atpase
B4W66_RS07095	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4W66_RS07100	COG0195	Participates in both transcription termination and antitermination
B4W66_RS07125	COG4473	ABC transporter
B4W66_RS07130	COG1131	(ABC) transporter
B4W66_RS07135	COG0537	adenosine 5'-monophosphoramidase activity
B4W66_RS07145	COG1316	TRANSCRIPTIONal
B4W66_RS07155	COG0802	atpase or kinase
B4W66_RS07160	COG2252	PERMEase
B4W66_RS07165	COG0561	phosphatase activity
B4W66_RS07175	COG3715	PTS system
B4W66_RS07180	COG3716	PTS system mannose fructose sorbose family IID component
B4W66_RS07205	COG0439	Biotin carboxylase
B4W66_RS07220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4W66_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
B4W66_RS07230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4W66_RS07255	COG1024	Enoyl-CoA hydratase
B4W66_RS07260	COG0484	heat shock protein binding
B4W66_RS07290	COG0588	phosphoglycerate mutase activity
B4W66_RS07295	COG2261	transglycosylase associated protein
B4W66_RS07330	COG1335	isochorismatase
B4W66_RS07340	COG0436	Aminotransferase
B4W66_RS07350	COG0561	phosphatase activity
B4W66_RS07355	COG0252	asparaginase activity
B4W66_RS07370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4W66_RS07380	COG1129	ABC transporter
B4W66_RS07395	COG1132	(ABC) transporter
B4W66_RS07400	COG4988	ABC transporter
B4W66_RS07405	COG1120	ATPase activity
B4W66_RS07430	COG3942	CHAP domain
B4W66_RS07430	COG1388	LysM domain
B4W66_RS07455	COG5433	transposase activity
B4W66_RS07460	COG1482	cell wall glycoprotein biosynthetic process
B4W66_RS07465	COG1940	carbohydrate kinase activity
B4W66_RS07475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4W66_RS07475	COG1263	PTS System
B4W66_RS07475	COG2190	(PTS) system
B4W66_RS07480	COG1621	beta-fructofuranosidase activity
B4W66_RS07485	COG1609	Transcriptional regulator
B4W66_RS07505	COG2131	deaminase
B4W66_RS07510	COG0006	proline dipeptidase activity
B4W66_RS07540	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4W66_RS07545	COG4824	toxin secretion phage lysis holin
B4W66_RS07685	COG1475	DNA binding
B4W66_RS07750	COG3723	Recombinational DNA repair protein, rece pathway
B4W66_RS07775	COG3935	DnaD domain protein
B4W66_RS07810	COG3561	AntA/AntB antirepressor
B4W66_RS07820	COG1396	sequence-specific DNA binding
B4W66_RS07870	COG1194	a g-specific adenine glycosylase
B4W66_RS07880	COG3118	belongs to the thioredoxin family
B4W66_RS07910	COG0681	Belongs to the peptidase S26 family
B4W66_RS07915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4W66_RS07930	COG1882	Formate acetyltransferase
B4W66_RS07935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4W66_RS07950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4W66_RS07960	COG2814	Major facilitator Superfamily
B4W66_RS07965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4W66_RS07990	COG0789	Transcriptional regulator
B4W66_RS08025	COG2081	HI0933 family
B4W66_RS08035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4W66_RS08040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B4W66_RS08060	COG0456	acetyltransferase
B4W66_RS08065	COG1214	PFAM Peptidase M22, glycoprotease
B4W66_RS08080	COG0174	glutamine synthetase
B4W66_RS08085	COG0789	Transcriptional regulator
B4W66_RS08100	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4W66_RS08155	COG0668	transmembrane transport
B4W66_RS08165	COG4720	Psort location CytoplasmicMembrane, score
B4W66_RS08170	COG0351	phosphomethylpyrimidine kinase
B4W66_RS08215	COG1929	Belongs to the glycerate kinase type-1 family
B4W66_RS08220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4W66_RS08250	COG0577	efflux transmembrane transporter activity
B4W66_RS08255	COG1136	(ABC) transporter
B4W66_RS08280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4W66_RS08280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4W66_RS08285	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4W66_RS08345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4W66_RS08350	COG1476	TRANSCRIPTIONal
B4W66_RS08370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4W66_RS08380	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4W66_RS08400	COG1045	serine acetyltransferase
B4W66_RS08415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4W66_RS08430	COG3711	transcriptional antiterminator
B4W66_RS08455	COG0431	NADPH-dependent FMN reductase
B4W66_RS08460	COG1846	Transcriptional regulator
B4W66_RS08480	COG4589	Belongs to the CDS family
B4W66_RS08490	COG1862	Preprotein translocase
B4W66_RS08500	COG1523	belongs to the glycosyl hydrolase 13 family
B4W66_RS08515	COG3842	ATPase activity
B4W66_RS08555	COG2190	(PTS) system
B4W66_RS08555	COG1263	PTS System
B4W66_RS08555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4W66_RS08560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4W66_RS08580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4W66_RS08585	COG0512	Glutamine amidotransferase of anthranilate synthase
B4W66_RS08590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4W66_RS08620	COG0601	transmembrane transport
B4W66_RS08625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4W66_RS08630	COG1122	ATPase activity
B4W66_RS08650	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4W66_RS08660	COG1404	Belongs to the peptidase S8 family
B4W66_RS08660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4W66_RS08680	COG3711	transcriptional antiterminator
B4W66_RS08695	COG3942	CHAP domain
B4W66_RS08695	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4W66_RS08700	COG2205	protein histidine kinase activity
B4W66_RS08705	COG0745	RESPONSE REGULATOR receiver
B4W66_RS08710	COG0577	efflux transmembrane transporter activity
B4W66_RS08715	COG1136	(ABC) transporter
B4W66_RS08790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4W66_RS08805	COG1882	Formate acetyltransferase
B4W66_RS08810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4W66_RS08815	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4W66_RS08820	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4W66_RS08825	COG2390	Transcriptional regulator
B4W66_RS08830	COG1349	DNA-binding transcription factor activity
B4W66_RS08835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B4W66_RS08855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4W66_RS08870	COG0564	pseudouridine synthase activity
B4W66_RS08905	COG0542	response to heat
B4W66_RS08910	COG4463	regulation of RNA biosynthetic process
B4W66_RS08925	COG0450	alkyl hydroperoxide reductase
B4W66_RS08940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4W66_RS08950	COG3404	Formiminotransferase-cyclodeaminase
B4W66_RS08965	COG0531	amino acid
B4W66_RS08995	COG3590	peptidase
B4W66_RS09000	COG0366	Alpha amylase catalytic
B4W66_RS09005	COG1263	PTS System
B4W66_RS09005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4W66_RS09010	COG2188	Transcriptional regulator
B4W66_RS09020	COG1733	regulation of RNA biosynthetic process
B4W66_RS09025	COG2514	catechol 2,3-dioxygenase activity
B4W66_RS09035	COG0602	queuosine metabolic process
B4W66_RS09055	COG1328	CTP reductase activity
B4W66_RS09080	COG1393	Belongs to the ArsC family
B4W66_RS09095	COG0519	Catalyzes the synthesis of GMP from XMP
B4W66_RS09140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4W66_RS09145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4W66_RS09150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4W66_RS09235	COG1511	domain protein
B4W66_RS09255	COG0305	Participates in initiation and elongation during chromosome replication
B4W66_RS09285	COG1760	l-serine dehydratase
B4W66_RS09290	COG1760	l-serine dehydratase
B4W66_RS09295	COG0741	lytic transglycosylase activity
B4W66_RS09300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4W66_RS09315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4W66_RS09325	COG0612	Peptidase, M16
B4W66_RS09370	COG0517	IMP dehydrogenase activity
B4W66_RS09370	COG0516	GMP reductase activity
B4W66_RS09380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4W66_RS09385	COG0488	(ABC) transporter
B4W66_RS09430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4W66_RS09435	COG1475	DNA binding