locus-tag	class	description
D8S76_RS00010	COG0592	DNA-directed DNA polymerase activity
D8S76_RS00020	COG0012	GTP binding
D8S76_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8S76_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D8S76_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8S76_RS00065	COG0531	amino acid
D8S76_RS00245	COG3942	CHAP domain
D8S76_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8S76_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D8S76_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D8S76_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D8S76_RS00325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D8S76_RS00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8S76_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
D8S76_RS00355	COG1454	alcohol dehydrogenase
D8S76_RS00360	COG1064	alcohol dehydrogenase
D8S76_RS00365	COG0534	Mate efflux family protein
D8S76_RS00475	COG0201	protein transport
D8S76_RS00595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D8S76_RS00620	COG1121	(ABC) transporter
D8S76_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D8S76_RS00640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8S76_RS00665	COG1459	type II secretion system
D8S76_RS00670	COG4537	Required for transformation and DNA binding
D8S76_RS00710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D8S76_RS00715	COG1363	Peptidase, m42
D8S76_RS00730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8S76_RS00735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8S76_RS00745	COG1428	Deoxynucleoside kinase
D8S76_RS00750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D8S76_RS00795	COG4509	Sortase family
D8S76_RS00835	COG0251	oxidation-reduction process
D8S76_RS00850	COG1269	ATP hydrolysis coupled proton transport
D8S76_RS00855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8S76_RS00865	COG1527	subunit (C
D8S76_RS00870	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
D8S76_RS00905	COG1744	ABC transporter substrate-binding protein PnrA-like
D8S76_RS00950	COG0626	cystathionine gamma-synthase activity
D8S76_RS00980	COG3623	hexulose-6-phosphate isomerase
D8S76_RS01005	COG4175	Glycine betaine
D8S76_RS01005	COG3448	diguanylate cyclase activity
D8S76_RS01015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D8S76_RS01015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D8S76_RS01035	COG3969	phosphoadenosine phosphosulfate
D8S76_RS01040	COG1475	DNA binding
D8S76_RS01090	COG1268	BioY protein
D8S76_RS01095	COG1234	tRNA 3'-trailer cleavage
D8S76_RS01130	COG5433	transposase activity
D8S76_RS01140	COG0705	Rhomboid family
D8S76_RS01140	COG0457	Tetratricopeptide repeat
D8S76_RS01160	COG1132	(ABC) transporter
D8S76_RS01165	COG1132	(ABC) transporter
D8S76_RS01175	COG0756	dUTP diphosphatase activity
D8S76_RS01200	COG3290	protein histidine kinase activity
D8S76_RS01225	COG1847	R3H domain protein
D8S76_RS01245	COG1175	transmembrane transport
D8S76_RS01250	COG0395	ABC-type sugar transport system, permease component
D8S76_RS01260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8S76_RS01275	COG0084	hydrolase, TatD family'
D8S76_RS01300	COG1564	THIamine pyrophosphokinase
D8S76_RS01315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8S76_RS01355	COG0765	amino acid transport
D8S76_RS01375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8S76_RS01385	COG0719	Fe-S assembly protein
D8S76_RS01390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8S76_RS01405	COG1686	Belongs to the peptidase S11 family
D8S76_RS01410	COG1686	Belongs to the peptidase S11 family
D8S76_RS01415	COG4166	transmembrane transport
D8S76_RS01420	COG0601	transmembrane transport
D8S76_RS01425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8S76_RS01430	COG0444	Belongs to the ABC transporter superfamily
D8S76_RS01480	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D8S76_RS01485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D8S76_RS01490	COG1534	Rna-binding protein
D8S76_RS01500	COG1713	HD superfamily hydrolase involved in NAD metabolism
D8S76_RS01505	COG0799	negative regulation of ribosome biogenesis
D8S76_RS01510	COG2226	methyltransferase
D8S76_RS01530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8S76_RS01535	COG1464	Belongs to the NlpA lipoprotein family
D8S76_RS01550	COG1114	Component of the transport system for branched-chain amino acids
D8S76_RS01560	COG0569	domain protein
D8S76_RS01565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8S76_RS01575	COG1704	LemA family
D8S76_RS01590	COG0745	RESPONSE REGULATOR receiver
D8S76_RS01610	COG1484	DNA-dependent DNA replication
D8S76_RS01620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D8S76_RS01640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D8S76_RS01655	COG1254	Belongs to the acylphosphatase family
D8S76_RS01660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8S76_RS01715	COG1187	pseudouridine synthase activity
D8S76_RS01730	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D8S76_RS01735	COG0671	phosphoesterase, PA-phosphatase related
D8S76_RS01740	COG1242	4 iron, 4 sulfur cluster binding
D8S76_RS01745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D8S76_RS01750	COG1253	flavin adenine dinucleotide binding
D8S76_RS01755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D8S76_RS01770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8S76_RS01775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8S76_RS01780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8S76_RS01785	COG1120	ATPase activity
D8S76_RS01795	COG2244	polysaccharide biosynthetic process
D8S76_RS01825	COG0470	DNA polymerase III
D8S76_RS01855	COG1393	Belongs to the ArsC family
D8S76_RS01860	COG0708	Exodeoxyribonuclease III
D8S76_RS01870	COG1304	FMN binding
D8S76_RS02070	COG0582	viral genome integration into host DNA
D8S76_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
D8S76_RS02085	COG0673	inositol 2-dehydrogenase activity
D8S76_RS02100	COG0494	nUDIX hydrolase
D8S76_RS02110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8S76_RS02200	COG1702	phosphate starvation-inducible protein PhoH
D8S76_RS02205	COG1573	uracil-dna glycosylase
D8S76_RS02215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D8S76_RS02320	COG0433	COG0433 Predicted ATPase
D8S76_RS02340	COG0557	exoribonuclease II activity
D8S76_RS02370	COG0463	Glycosyl transferase, family 2
D8S76_RS02375	COG0346	lactoylglutathione lyase activity
D8S76_RS02380	COG0778	Nitroreductase
D8S76_RS02385	COG0006	proline dipeptidase activity
D8S76_RS02390	COG1609	Transcriptional regulator
D8S76_RS02400	COG0438	transferase activity, transferring glycosyl groups
D8S76_RS02410	COG4555	ABC transporter
D8S76_RS02430	COG0183	Belongs to the thiolase family
D8S76_RS02445	COG0745	RESPONSE REGULATOR receiver
D8S76_RS02450	COG5002	protein histidine kinase activity
D8S76_RS02455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D8S76_RS02465	COG1196	nuclear chromosome segregation
D8S76_RS02480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D8S76_RS02565	COG4695	Portal protein
D8S76_RS02595	COG0124	histidyl-tRNA synthetase
D8S76_RS02605	COG0561	phosphatase activity
D8S76_RS02610	COG0561	phosphatase activity
D8S76_RS02615	COG0552	protein localization to endoplasmic reticulum
D8S76_RS02620	COG0477	Major facilitator Superfamily
D8S76_RS02625	COG3711	transcriptional antiterminator
D8S76_RS02630	COG2190	(PTS) system
D8S76_RS02630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8S76_RS02630	COG1263	PTS System
D8S76_RS02640	COG3689	TIGRFAM TIGR03943 family protein
D8S76_RS02645	COG0701	Predicted permease
D8S76_RS02655	COG2183	response to ionizing radiation
D8S76_RS02700	COG0826	peptidase U32
D8S76_RS02705	COG4443	Transcriptional Coactivator p15 (PC4)
D8S76_RS02750	COG0386	Belongs to the glutathione peroxidase family
D8S76_RS02755	COG1164	Oligoendopeptidase f
D8S76_RS02765	COG0772	Belongs to the SEDS family
D8S76_RS02800	COG1078	dGTPase activity
D8S76_RS02815	COG1609	Transcriptional regulator
D8S76_RS02825	COG3716	PTS system mannose fructose sorbose family IID component
D8S76_RS02830	COG3715	PTS system
D8S76_RS02835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8S76_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
D8S76_RS02865	COG0800	Aldolase
D8S76_RS02870	COG0546	phosphoglycolate phosphatase activity
D8S76_RS02880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8S76_RS02890	COG2884	Cell division ATP-binding protein ftsE
D8S76_RS02895	COG2177	Part of the ABC transporter FtsEX involved in
D8S76_RS02910	COG1199	ATP-dependent helicase activity
D8S76_RS02910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8S76_RS02915	COG0436	Aminotransferase
D8S76_RS02955	COG2222	sugar isomerase
D8S76_RS02965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D8S76_RS02970	COG0716	FMN binding
D8S76_RS02980	COG0038	chloride channel
D8S76_RS03070	COG1131	(ABC) transporter
D8S76_RS03095	COG4708	membrane
D8S76_RS03105	COG1597	lipid kinase activity
D8S76_RS03190	COG0577	efflux transmembrane transporter activity
D8S76_RS03200	COG2321	neutral zinc metallopeptidase
D8S76_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8S76_RS03225	COG1970	mechanosensitive ion channel activity
D8S76_RS03230	COG0358	DNA primase activity
D8S76_RS03235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8S76_RS03240	COG2151	metal-sulfur cluster biosynthetic enzyme
D8S76_RS03285	COG1216	Glycosyl transferase, family 2
D8S76_RS03345	COG1368	sulfuric ester hydrolase activity
D8S76_RS03350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D8S76_RS03370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8S76_RS03375	COG0285	dihydrofolate synthase activity
D8S76_RS03385	COG1104	cysteine desulfurase activity
D8S76_RS03410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D8S76_RS03415	COG0583	DNA-binding transcription factor activity
D8S76_RS03425	COG0564	pseudouridine synthase activity
D8S76_RS03460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8S76_RS03465	COG1136	(ABC) transporter
D8S76_RS03470	COG0577	efflux transmembrane transporter activity
D8S76_RS03475	COG0584	glycerophosphoryl diester phosphodiesterase
D8S76_RS03485	COG1837	Belongs to the UPF0109 family
D8S76_RS03535	COG1349	DNA-binding transcription factor activity
D8S76_RS03540	COG1105	Belongs to the carbohydrate kinase PfkB family
D8S76_RS03545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8S76_RS03545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8S76_RS03545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8S76_RS03550	COG3942	CHAP domain
D8S76_RS03550	COG1705	Flagellar rod assembly protein muramidase FlgJ
D8S76_RS03555	COG1705	Flagellar rod assembly protein muramidase FlgJ
D8S76_RS03555	COG1388	LysM domain
D8S76_RS03580	COG0105	UTP biosynthetic process
D8S76_RS03600	COG0488	(ABC) transporter
D8S76_RS03610	COG0242	peptide deformylase activity
D8S76_RS03615	COG0737	Belongs to the 5'-nucleotidase family
D8S76_RS03620	COG2357	RelA SpoT domain protein
D8S76_RS03625	COG0745	RESPONSE REGULATOR receiver
D8S76_RS03660	COG3425	synthase
D8S76_RS03670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D8S76_RS03715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D8S76_RS03730	COG0583	DNA-binding transcription factor activity
D8S76_RS03760	COG0765	amino acid transport
D8S76_RS03780	COG0187	DNA topoisomerase II activity
D8S76_RS03795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8S76_RS03815	COG0539	negative regulation of cytoplasmic translation
D8S76_RS03860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8S76_RS03865	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D8S76_RS03875	COG0300	oxidoreductase activity
D8S76_RS03880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8S76_RS03880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D8S76_RS03895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D8S76_RS03900	COG2384	SAM-dependent methyltransferase
D8S76_RS03910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8S76_RS03915	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D8S76_RS03925	COG1088	dTDP-glucose 4,6-dehydratase activity
D8S76_RS03930	COG0582	viral genome integration into host DNA
D8S76_RS04035	COG1783	phage Terminase large subunit
D8S76_RS04175	COG1051	belongs to the nudix hydrolase family
D8S76_RS04180	COG0628	permease
D8S76_RS04185	COG0457	Tetratricopeptide repeat
D8S76_RS04190	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D8S76_RS04210	COG1129	ABC transporter
D8S76_RS04230	COG0488	(ABC) transporter
D8S76_RS04235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8S76_RS04240	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8S76_RS04240	COG0022	dehydrogenase e1 component
D8S76_RS04245	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8S76_RS04260	COG5492	domain, Protein
D8S76_RS04265	COG0095	Lipoate-protein ligase
D8S76_RS04270	COG3442	glutamine amidotransferase
D8S76_RS04275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8S76_RS04280	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D8S76_RS04300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8S76_RS04310	COG0647	UMP catabolic process
D8S76_RS04325	COG0105	UTP biosynthetic process
D8S76_RS04360	COG3715	PTS system
D8S76_RS04365	COG3716	PTS system mannose fructose sorbose family IID component
D8S76_RS04370	COG2972	Histidine kinase
D8S76_RS04375	COG2207	Transcriptional regulator
D8S76_RS04375	COG4753	response regulator
D8S76_RS04385	COG1012	belongs to the aldehyde dehydrogenase family
D8S76_RS04400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8S76_RS04475	COG1131	(ABC) transporter
D8S76_RS04490	COG1396	sequence-specific DNA binding
D8S76_RS04520	COG0285	dihydrofolate synthase activity
D8S76_RS04540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D8S76_RS04555	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8S76_RS04560	COG1177	transmembrane transport
D8S76_RS04570	COG4565	transcriptional regulatory protein
D8S76_RS04575	COG3290	protein histidine kinase activity
D8S76_RS04580	COG3493	citrate carrier protein
D8S76_RS04595	COG3700	Belongs to the class B bacterial acid phosphatase family
D8S76_RS04600	COG0038	chloride channel
D8S76_RS04610	COG0628	permease
D8S76_RS04620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D8S76_RS04635	COG1104	cysteine desulfurase activity
D8S76_RS04650	COG2357	RelA SpoT domain protein
D8S76_RS04660	COG0564	pseudouridine synthase activity
D8S76_RS04665	COG0280	phosphate acetyltransferase
D8S76_RS04670	COG4221	oxidoreductase activity
D8S76_RS04685	COG1174	glycine betaine transport
D8S76_RS04705	COG2233	PERMEase
D8S76_RS04730	COG2890	protein-(glutamine-N5) methyltransferase activity
D8S76_RS04760	COG1132	(ABC) transporter
D8S76_RS04765	COG1132	(ABC) transporter
D8S76_RS04785	COG3764	Sortase (surface protein transpeptidase)
D8S76_RS04790	COG0346	lactoylglutathione lyase activity
D8S76_RS04805	COG1597	lipid kinase activity
D8S76_RS04810	COG1272	protein, Hemolysin III
D8S76_RS04830	COG0758	DNA mediated transformation
D8S76_RS04835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D8S76_RS04885	COG0511	ligase activity, forming carbon-carbon bonds
D8S76_RS04890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D8S76_RS04905	COG2851	Citrate transporter
D8S76_RS04915	COG0511	ligase activity, forming carbon-carbon bonds
D8S76_RS04920	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D8S76_RS04950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D8S76_RS04970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8S76_RS04980	COG2188	Transcriptional regulator
D8S76_RS05000	COG0488	(ABC) transporter
D8S76_RS05010	COG0352	thiamine-phosphate diphosphorylase activity
D8S76_RS05010	COG0351	phosphomethylpyrimidine kinase
D8S76_RS05015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8S76_RS05025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D8S76_RS05025	COG1328	CTP reductase activity
D8S76_RS05030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8S76_RS05060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8S76_RS05080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D8S76_RS05085	COG4684	Psort location CytoplasmicMembrane, score
D8S76_RS05090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8S76_RS05095	COG1079	Belongs to the binding-protein-dependent transport system permease family
D8S76_RS05100	COG4603	Belongs to the binding-protein-dependent transport system permease family
D8S76_RS05105	COG3845	ABC transporter
D8S76_RS05110	COG1744	ABC transporter substrate-binding protein PnrA-like
D8S76_RS05115	COG0295	cytidine deaminase activity
D8S76_RS05120	COG2813	Specifically methylates the guanine in position
D8S76_RS05135	COG5002	protein histidine kinase activity
D8S76_RS05140	COG0745	RESPONSE REGULATOR receiver
D8S76_RS05155	COG0704	Plays a role in the regulation of phosphate uptake
D8S76_RS05170	COG0581	inorganic phosphate transmembrane transporter activity
D8S76_RS05175	COG0573	inorganic phosphate transmembrane transporter activity
D8S76_RS05185	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D8S76_RS05185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8S76_RS05190	COG0483	inositol monophosphate 1-phosphatase activity
D8S76_RS05205	COG0196	riboflavin kinase activity
D8S76_RS05235	COG4591	ABC-type transport system involved in lipoprotein release permease component
D8S76_RS05235	COG1136	(ABC) transporter
D8S76_RS05285	COG5433	transposase activity
D8S76_RS05295	COG1115	amino acid carrier protein
D8S76_RS05300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D8S76_RS05310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8S76_RS05315	COG1126	abc transporter atp-binding protein
D8S76_RS05320	COG0765	amino acid transport
D8S76_RS05325	COG2824	Alkylphosphonate utilization operon protein PhnA
D8S76_RS05340	COG0469	pyruvate kinase activity
D8S76_RS05355	COG1725	Transcriptional regulator
D8S76_RS05360	COG1131	(ABC) transporter
D8S76_RS05385	COG0058	SHG alpha-glucan phosphorylase activity
D8S76_RS05390	COG1640	4-alpha-glucanotransferase
D8S76_RS05395	COG1609	Transcriptional regulator
D8S76_RS05400	COG2182	Extracellular solute-binding protein
D8S76_RS05405	COG1175	transmembrane transport
D8S76_RS05410	COG3833	ABC-type maltose transport systems, permease component
D8S76_RS05430	COG0657	acetylesterase activity
D8S76_RS05435	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D8S76_RS05445	COG1696	Membrane protein involved in D-alanine export
D8S76_RS05465	COG0765	amino acid transport
D8S76_RS05470	COG1126	abc transporter atp-binding protein
D8S76_RS05485	COG1447	Phosphotransferase system cellobiose-specific component IIA
D8S76_RS05535	COG1187	pseudouridine synthase activity
D8S76_RS05545	COG2814	Major facilitator Superfamily
D8S76_RS05585	COG1132	(ABC) transporter
D8S76_RS05590	COG2375	cellular response to nickel ion
D8S76_RS05590	COG1132	(ABC) transporter
D8S76_RS05640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8S76_RS05655	COG0791	NLP P60 protein
D8S76_RS05655	COG0741	lytic transglycosylase activity
D8S76_RS05710	COG2946	Replication initiation factor
D8S76_RS05720	COG1674	ftsk spoiiie
D8S76_RS05755	COG1309	transcriptional regulator
D8S76_RS05790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D8S76_RS05790	COG0551	DNA topoisomerase type I activity
D8S76_RS05855	COG1484	DNA-dependent DNA replication
D8S76_RS05905	COG4109	DRTGG domain
D8S76_RS05910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D8S76_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
D8S76_RS05955	COG0800	Aldolase
D8S76_RS05960	COG2186	Transcriptional regulator
D8S76_RS05965	COG3250	beta-galactosidase activity
D8S76_RS05975	COG2211	Major facilitator Superfamily
D8S76_RS05995	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D8S76_RS05995	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D8S76_RS06005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8S76_RS06010	COG1956	GAF domain-containing protein
D8S76_RS06030	COG0513	Belongs to the DEAD box helicase family
D8S76_RS06035	COG0726	polysaccharide deacetylase
D8S76_RS06055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D8S76_RS06060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8S76_RS06085	COG5433	transposase activity
D8S76_RS06105	COG1476	TRANSCRIPTIONal
D8S76_RS06120	COG4122	O-methyltransferase activity
D8S76_RS06140	COG1187	pseudouridine synthase activity
D8S76_RS06185	COG0658	competence protein
D8S76_RS06185	COG2333	competence protein COMEC
D8S76_RS06190	COG1596	polysaccharide export
D8S76_RS06190	COG1555	photosystem II stabilization
D8S76_RS06195	COG0204	Acyl-transferase
D8S76_RS06200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D8S76_RS06215	COG0513	Belongs to the DEAD box helicase family
D8S76_RS06235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8S76_RS06250	COG0768	penicillin binding
D8S76_RS06255	COG2116	formate transmembrane transporter activity
D8S76_RS06265	COG1827	regulation of RNA biosynthetic process
D8S76_RS06280	COG2217	Heavy metal translocating P-type atpase
D8S76_RS06295	COG2755	lipolytic protein G-D-S-L family
D8S76_RS06310	COG5433	transposase activity
D8S76_RS06320	COG0497	DNA recombination
D8S76_RS06325	COG1438	arginine binding
D8S76_RS06330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D8S76_RS06355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8S76_RS06360	COG0415	Belongs to the DNA photolyase family
D8S76_RS06370	COG0765	amino acid transport
D8S76_RS06375	COG4703	Protein of unknown function (DUF1797)
D8S76_RS06380	COG0542	response to heat
D8S76_RS06385	COG0494	nUDIX hydrolase
D8S76_RS06400	COG3599	regulation of cell shape
D8S76_RS06405	COG2302	S4 RNA-binding domain
D8S76_RS06420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D8S76_RS06455	COG1217	gtp-binding protein TYPA
D8S76_RS06460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D8S76_RS06465	COG1940	carbohydrate kinase activity
D8S76_RS06475	COG0783	Belongs to the Dps family
D8S76_RS06490	COG4470	Protein conserved in bacteria
D8S76_RS06495	COG1609	Transcriptional regulator
D8S76_RS06500	COG3480	Lon protease (S16) C-terminal proteolytic domain
D8S76_RS06510	COG0742	ribosomal rna small subunit methyltransferase
D8S76_RS06520	COG0549	Belongs to the carbamate kinase family
D8S76_RS06525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8S76_RS06530	COG1288	antiporter activity
D8S76_RS06545	COG2235	arginine
D8S76_RS06570	COG2972	Histidine kinase
D8S76_RS06585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8S76_RS06590	COG0785	Cytochrome C biogenesis protein
D8S76_RS06595	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D8S76_RS06600	COG1518	maintenance of DNA repeat elements
D8S76_RS06660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D8S76_RS06660	COG1605	Chorismate mutase
D8S76_RS06680	COG2226	methyltransferase
D8S76_RS06690	COG3250	beta-galactosidase activity
D8S76_RS06695	COG2207	Transcriptional regulator
D8S76_RS06695	COG4753	response regulator
D8S76_RS06700	COG2972	Histidine kinase
D8S76_RS06710	COG1653	transport
D8S76_RS06715	COG0395	ABC-type sugar transport system, permease component
D8S76_RS06720	COG1175	transmembrane transport
D8S76_RS06725	COG1940	carbohydrate kinase activity
D8S76_RS06730	COG2723	6-phospho-beta-galactosidase activity
D8S76_RS06735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D8S76_RS06750	COG0383	alpha-mannosidase activity
D8S76_RS06785	COG4824	toxin secretion phage lysis holin
D8S76_RS06900	COG1475	DNA binding
D8S76_RS07005	COG3561	AntA/AntB antirepressor
D8S76_RS07130	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D8S76_RS07135	COG1739	Uncharacterized protein family UPF0029
D8S76_RS07145	COG1098	S1 RNA binding domain
D8S76_RS07155	COG2197	response regulator
D8S76_RS07160	COG4585	Histidine kinase
D8S76_RS07170	COG2815	serine threonine protein kinase
D8S76_RS07170	COG0515	serine threonine protein kinase
D8S76_RS07180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8S76_RS07180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8S76_RS07190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8S76_RS07210	COG0583	DNA-binding transcription factor activity
D8S76_RS07215	COG0183	Belongs to the thiolase family
D8S76_RS07220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D8S76_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
D8S76_RS07235	COG2610	gluconate transmembrane transporter activity
D8S76_RS07250	COG0116	Belongs to the methyltransferase superfamily
D8S76_RS07275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8S76_RS07280	COG3579	cysteine-type endopeptidase activity
D8S76_RS07290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D8S76_RS07295	COG1113	amino acid transport
D8S76_RS07300	COG0492	ferredoxin-NADP+ reductase activity
D8S76_RS07310	COG1126	abc transporter atp-binding protein
D8S76_RS07320	COG0513	Belongs to the DEAD box helicase family
D8S76_RS07330	COG0768	penicillin binding
D8S76_RS07365	COG1131	(ABC) transporter
D8S76_RS07390	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8S76_RS07395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D8S76_RS07435	COG1755	Isoprenylcysteine carboxyl methyltransferase
D8S76_RS07440	COG0656	L-ascorbic acid biosynthetic process
D8S76_RS07450	COG1283	sodium-dependent phosphate transmembrane transporter activity
D8S76_RS07470	COG0561	phosphatase activity
D8S76_RS07475	COG2860	membrane
D8S76_RS07530	COG2217	Heavy metal translocating P-type atpase
D8S76_RS07560	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D8S76_RS07565	COG0195	Participates in both transcription termination and antitermination
D8S76_RS07590	COG4473	ABC transporter
D8S76_RS07595	COG1131	(ABC) transporter
D8S76_RS07600	COG0537	adenosine 5'-monophosphoramidase activity
D8S76_RS07610	COG1316	TRANSCRIPTIONal
D8S76_RS07620	COG0802	atpase or kinase
D8S76_RS07625	COG2252	PERMEase
D8S76_RS07630	COG0561	phosphatase activity
D8S76_RS07640	COG3715	PTS system
D8S76_RS07645	COG3716	PTS system mannose fructose sorbose family IID component
D8S76_RS07670	COG0439	Biotin carboxylase
D8S76_RS07685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8S76_RS07690	COG1028	Short-chain dehydrogenase reductase Sdr
D8S76_RS07695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D8S76_RS07720	COG1024	Enoyl-CoA hydratase
D8S76_RS07750	COG1876	peptidase activity
D8S76_RS07755	COG0588	phosphoglycerate mutase activity
D8S76_RS07760	COG2261	transglycosylase associated protein
D8S76_RS07785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D8S76_RS07785	COG0574	Belongs to the PEP-utilizing enzyme family
D8S76_RS07795	COG1335	isochorismatase
D8S76_RS07805	COG0436	Aminotransferase
D8S76_RS07815	COG0561	phosphatase activity
D8S76_RS07820	COG0252	asparaginase activity
D8S76_RS07835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D8S76_RS07845	COG1129	ABC transporter
D8S76_RS07860	COG1132	(ABC) transporter
D8S76_RS07865	COG4988	ABC transporter
D8S76_RS07870	COG1120	ATPase activity
D8S76_RS07915	COG1482	cell wall glycoprotein biosynthetic process
D8S76_RS07920	COG1940	carbohydrate kinase activity
D8S76_RS07930	COG1263	PTS System
D8S76_RS07930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8S76_RS07930	COG2190	(PTS) system
D8S76_RS07935	COG1621	beta-fructofuranosidase activity
D8S76_RS07940	COG1609	Transcriptional regulator
D8S76_RS07960	COG2131	deaminase
D8S76_RS07965	COG0006	proline dipeptidase activity
D8S76_RS08005	COG1194	a g-specific adenine glycosylase
D8S76_RS08015	COG3118	belongs to the thioredoxin family
D8S76_RS08045	COG0681	Belongs to the peptidase S26 family
D8S76_RS08050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D8S76_RS08065	COG1882	Formate acetyltransferase
D8S76_RS08070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D8S76_RS08085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D8S76_RS08095	COG2814	Major facilitator Superfamily
D8S76_RS08100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8S76_RS08125	COG0789	Transcriptional regulator
D8S76_RS08145	COG0577	efflux transmembrane transporter activity
D8S76_RS08145	COG1136	(ABC) transporter
D8S76_RS08160	COG2081	HI0933 family
D8S76_RS08170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D8S76_RS08175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D8S76_RS08195	COG0456	acetyltransferase
D8S76_RS08200	COG1214	PFAM Peptidase M22, glycoprotease
D8S76_RS08215	COG0174	glutamine synthetase
D8S76_RS08220	COG0789	Transcriptional regulator
D8S76_RS08235	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D8S76_RS08290	COG0668	transmembrane transport
D8S76_RS08300	COG4720	Psort location CytoplasmicMembrane, score
D8S76_RS08305	COG0351	phosphomethylpyrimidine kinase
D8S76_RS08350	COG1929	Belongs to the glycerate kinase type-1 family
D8S76_RS08355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D8S76_RS08395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D8S76_RS08395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D8S76_RS08400	COG1447	Phosphotransferase system cellobiose-specific component IIA
D8S76_RS08460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D8S76_RS08465	COG1476	TRANSCRIPTIONal
D8S76_RS08485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8S76_RS08495	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D8S76_RS08515	COG1045	serine acetyltransferase
D8S76_RS08530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D8S76_RS08545	COG3711	transcriptional antiterminator
D8S76_RS08575	COG1846	Transcriptional regulator
D8S76_RS08595	COG4589	Belongs to the CDS family
D8S76_RS08605	COG1862	Preprotein translocase
D8S76_RS08615	COG1523	belongs to the glycosyl hydrolase 13 family
D8S76_RS08630	COG3842	ATPase activity
D8S76_RS08670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8S76_RS08670	COG2190	(PTS) system
D8S76_RS08670	COG1263	PTS System
D8S76_RS08675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8S76_RS08690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D8S76_RS08695	COG0512	Glutamine amidotransferase of anthranilate synthase
D8S76_RS08700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8S76_RS08735	COG0601	transmembrane transport
D8S76_RS08765	COG0803	Belongs to the bacterial solute-binding protein 9 family
D8S76_RS08790	COG3711	transcriptional antiterminator
D8S76_RS08805	COG1705	Flagellar rod assembly protein muramidase FlgJ
D8S76_RS08805	COG3942	CHAP domain
D8S76_RS08810	COG2205	protein histidine kinase activity
D8S76_RS08815	COG0745	RESPONSE REGULATOR receiver
D8S76_RS08820	COG0577	efflux transmembrane transporter activity
D8S76_RS08825	COG1136	(ABC) transporter
D8S76_RS08900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D8S76_RS08915	COG1882	Formate acetyltransferase
D8S76_RS08920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D8S76_RS08925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D8S76_RS08930	COG1447	Phosphotransferase system cellobiose-specific component IIA
D8S76_RS08935	COG2390	Transcriptional regulator
D8S76_RS08940	COG1349	DNA-binding transcription factor activity
D8S76_RS08945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D8S76_RS08965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8S76_RS08980	COG0564	pseudouridine synthase activity
D8S76_RS09015	COG0542	response to heat
D8S76_RS09020	COG4463	regulation of RNA biosynthetic process
D8S76_RS09035	COG0450	alkyl hydroperoxide reductase
D8S76_RS09050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D8S76_RS09060	COG3404	Formiminotransferase-cyclodeaminase
D8S76_RS09075	COG0531	amino acid
D8S76_RS09105	COG3590	peptidase
D8S76_RS09110	COG0366	Alpha amylase catalytic
D8S76_RS09115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8S76_RS09115	COG1263	PTS System
D8S76_RS09120	COG2188	Transcriptional regulator
D8S76_RS09130	COG1733	regulation of RNA biosynthetic process
D8S76_RS09135	COG2514	catechol 2,3-dioxygenase activity
D8S76_RS09145	COG0602	queuosine metabolic process
D8S76_RS09160	COG1328	CTP reductase activity
D8S76_RS09185	COG1393	Belongs to the ArsC family
D8S76_RS09200	COG0519	Catalyzes the synthesis of GMP from XMP
D8S76_RS09210	COG2814	Major facilitator Superfamily
D8S76_RS09245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8S76_RS09250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8S76_RS09255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8S76_RS09340	COG1511	domain protein
D8S76_RS09360	COG0305	Participates in initiation and elongation during chromosome replication
D8S76_RS09390	COG1760	l-serine dehydratase
D8S76_RS09395	COG1760	l-serine dehydratase
D8S76_RS09400	COG0741	lytic transglycosylase activity
D8S76_RS09405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D8S76_RS09420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D8S76_RS09430	COG0612	Peptidase, M16
D8S76_RS09450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D8S76_RS09470	COG0516	GMP reductase activity
D8S76_RS09470	COG0517	IMP dehydrogenase activity
D8S76_RS09480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8S76_RS09485	COG0488	(ABC) transporter
D8S76_RS09525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8S76_RS09530	COG1475	DNA binding