locus-tag	class	description
G8B45_RS00010	COG0592	DNA-directed DNA polymerase activity
G8B45_RS00020	COG0012	GTP binding
G8B45_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8B45_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8B45_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8B45_RS00065	COG0531	amino acid
G8B45_RS00245	COG3942	CHAP domain
G8B45_RS00265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8B45_RS00275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8B45_RS00290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8B45_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G8B45_RS00330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8B45_RS00350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8B45_RS00365	COG1012	belongs to the aldehyde dehydrogenase family
G8B45_RS00365	COG1454	alcohol dehydrogenase
G8B45_RS00370	COG1064	alcohol dehydrogenase
G8B45_RS00375	COG0534	Mate efflux family protein
G8B45_RS00485	COG0201	protein transport
G8B45_RS00635	COG1121	(ABC) transporter
G8B45_RS00640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8B45_RS00655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8B45_RS00655	COG4499	WXG100 protein secretion system (Wss), protein YukC
G8B45_RS00675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8B45_RS00680	COG1459	type II secretion system
G8B45_RS00685	COG4537	Required for transformation and DNA binding
G8B45_RS00725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G8B45_RS00730	COG1363	Peptidase, m42
G8B45_RS00740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8B45_RS00745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8B45_RS00755	COG1428	Deoxynucleoside kinase
G8B45_RS00760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8B45_RS00820	COG2031	fatty acid transporter
G8B45_RS00835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8B45_RS00850	COG0251	oxidation-reduction process
G8B45_RS00865	COG1269	ATP hydrolysis coupled proton transport
G8B45_RS00870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8B45_RS00880	COG1527	subunit (C
G8B45_RS00885	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
G8B45_RS00920	COG1744	ABC transporter substrate-binding protein PnrA-like
G8B45_RS00965	COG0626	cystathionine gamma-synthase activity
G8B45_RS00995	COG3623	hexulose-6-phosphate isomerase
G8B45_RS01015	COG3448	diguanylate cyclase activity
G8B45_RS01015	COG4175	Glycine betaine
G8B45_RS01025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8B45_RS01025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8B45_RS01055	COG1268	BioY protein
G8B45_RS01060	COG1234	tRNA 3'-trailer cleavage
G8B45_RS01105	COG0457	Tetratricopeptide repeat
G8B45_RS01105	COG0705	Rhomboid family
G8B45_RS01125	COG1132	(ABC) transporter
G8B45_RS01130	COG1132	(ABC) transporter
G8B45_RS01140	COG0756	dUTP diphosphatase activity
G8B45_RS01165	COG3290	protein histidine kinase activity
G8B45_RS01190	COG1847	R3H domain protein
G8B45_RS01210	COG1175	transmembrane transport
G8B45_RS01215	COG0395	ABC-type sugar transport system, permease component
G8B45_RS01230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8B45_RS01245	COG0084	hydrolase, TatD family'
G8B45_RS01270	COG1564	THIamine pyrophosphokinase
G8B45_RS01285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8B45_RS01325	COG0765	amino acid transport
G8B45_RS01345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8B45_RS01355	COG0719	Fe-S assembly protein
G8B45_RS01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8B45_RS01375	COG1686	Belongs to the peptidase S11 family
G8B45_RS01380	COG1686	Belongs to the peptidase S11 family
G8B45_RS01385	COG4166	transmembrane transport
G8B45_RS01390	COG0601	transmembrane transport
G8B45_RS01395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8B45_RS01400	COG0444	Belongs to the ABC transporter superfamily
G8B45_RS01450	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G8B45_RS01455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G8B45_RS01460	COG1534	Rna-binding protein
G8B45_RS01470	COG1713	HD superfamily hydrolase involved in NAD metabolism
G8B45_RS01475	COG1335	isochorismatase
G8B45_RS01480	COG0799	negative regulation of ribosome biogenesis
G8B45_RS01485	COG2226	methyltransferase
G8B45_RS01500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B45_RS01505	COG1464	Belongs to the NlpA lipoprotein family
G8B45_RS01520	COG1114	Component of the transport system for branched-chain amino acids
G8B45_RS01530	COG0569	domain protein
G8B45_RS01535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8B45_RS01545	COG1704	LemA family
G8B45_RS01560	COG0745	RESPONSE REGULATOR receiver
G8B45_RS01580	COG1484	DNA-dependent DNA replication
G8B45_RS01590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G8B45_RS01610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8B45_RS01625	COG1254	Belongs to the acylphosphatase family
G8B45_RS01630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8B45_RS01685	COG1187	pseudouridine synthase activity
G8B45_RS01700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G8B45_RS01705	COG0671	phosphoesterase, PA-phosphatase related
G8B45_RS01710	COG1242	4 iron, 4 sulfur cluster binding
G8B45_RS01715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G8B45_RS01720	COG1253	flavin adenine dinucleotide binding
G8B45_RS01725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G8B45_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8B45_RS01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8B45_RS01750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G8B45_RS01755	COG1120	ATPase activity
G8B45_RS01770	COG2244	polysaccharide biosynthetic process
G8B45_RS01795	COG0470	DNA polymerase III
G8B45_RS01825	COG1393	Belongs to the ArsC family
G8B45_RS01830	COG0708	Exodeoxyribonuclease III
G8B45_RS01835	COG1304	FMN binding
G8B45_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
G8B45_RS01915	COG0673	inositol 2-dehydrogenase activity
G8B45_RS01930	COG0494	nUDIX hydrolase
G8B45_RS01940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8B45_RS02035	COG1573	uracil-dna glycosylase
G8B45_RS02045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G8B45_RS02145	COG2274	protein secretion by the type I secretion system
G8B45_RS02225	COG0433	COG0433 Predicted ATPase
G8B45_RS02230	COG2814	Major facilitator Superfamily
G8B45_RS02245	COG0557	exoribonuclease II activity
G8B45_RS02275	COG0463	Glycosyl transferase, family 2
G8B45_RS02285	COG0778	Nitroreductase
G8B45_RS02290	COG0006	proline dipeptidase activity
G8B45_RS02295	COG1609	Transcriptional regulator
G8B45_RS02305	COG0438	transferase activity, transferring glycosyl groups
G8B45_RS02315	COG4555	ABC transporter
G8B45_RS02330	COG2376	Dihydroxyacetone kinase
G8B45_RS02340	COG2376	Dihydroxyacetone kinase
G8B45_RS02345	COG1461	Dihydroxyacetone kinase
G8B45_RS02350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
G8B45_RS02355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8B45_RS02365	COG0183	Belongs to the thiolase family
G8B45_RS02380	COG0745	RESPONSE REGULATOR receiver
G8B45_RS02385	COG5002	protein histidine kinase activity
G8B45_RS02390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G8B45_RS02400	COG1196	nuclear chromosome segregation
G8B45_RS02415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8B45_RS02530	COG1619	proteins homologs of microcin C7 resistance protein MccF
G8B45_RS02540	COG0561	phosphatase activity
G8B45_RS02545	COG0561	phosphatase activity
G8B45_RS02550	COG0552	protein localization to endoplasmic reticulum
G8B45_RS02555	COG0477	Major facilitator Superfamily
G8B45_RS02560	COG3711	transcriptional antiterminator
G8B45_RS02565	COG2190	(PTS) system
G8B45_RS02565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B45_RS02565	COG1263	PTS System
G8B45_RS02575	COG3689	TIGRFAM TIGR03943 family protein
G8B45_RS02580	COG0701	Predicted permease
G8B45_RS02590	COG2183	response to ionizing radiation
G8B45_RS02635	COG0826	peptidase U32
G8B45_RS02640	COG4443	Transcriptional Coactivator p15 (PC4)
G8B45_RS02690	COG0386	Belongs to the glutathione peroxidase family
G8B45_RS02695	COG1164	Oligoendopeptidase f
G8B45_RS02705	COG0772	Belongs to the SEDS family
G8B45_RS02735	COG1078	dGTPase activity
G8B45_RS02750	COG1609	Transcriptional regulator
G8B45_RS02760	COG3716	PTS system mannose fructose sorbose family IID component
G8B45_RS02765	COG3715	PTS system
G8B45_RS02770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B45_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
G8B45_RS02800	COG0800	Aldolase
G8B45_RS02805	COG0546	phosphoglycolate phosphatase activity
G8B45_RS02815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G8B45_RS02825	COG2884	Cell division ATP-binding protein ftsE
G8B45_RS02830	COG2177	Part of the ABC transporter FtsEX involved in
G8B45_RS02845	COG1199	ATP-dependent helicase activity
G8B45_RS02845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8B45_RS02850	COG0436	Aminotransferase
G8B45_RS02940	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B45_RS02970	COG2188	Transcriptional regulator
G8B45_RS02975	COG2222	sugar isomerase
G8B45_RS02985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G8B45_RS02990	COG0716	FMN binding
G8B45_RS03000	COG0038	chloride channel
G8B45_RS03015	COG0582	viral genome integration into host DNA
G8B45_RS03150	COG1475	DNA binding
G8B45_RS03295	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B45_RS03380	COG1131	(ABC) transporter
G8B45_RS03400	COG4708	membrane
G8B45_RS03410	COG1597	lipid kinase activity
G8B45_RS03495	COG0577	efflux transmembrane transporter activity
G8B45_RS03500	COG1136	(ABC) transporter
G8B45_RS03505	COG2321	neutral zinc metallopeptidase
G8B45_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B45_RS03530	COG1970	mechanosensitive ion channel activity
G8B45_RS03540	COG0358	DNA primase activity
G8B45_RS03545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8B45_RS03550	COG2151	metal-sulfur cluster biosynthetic enzyme
G8B45_RS03595	COG1216	Glycosyl transferase, family 2
G8B45_RS03655	COG1368	sulfuric ester hydrolase activity
G8B45_RS03660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G8B45_RS03680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8B45_RS03685	COG0285	dihydrofolate synthase activity
G8B45_RS03695	COG1104	cysteine desulfurase activity
G8B45_RS03725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G8B45_RS03730	COG0583	DNA-binding transcription factor activity
G8B45_RS03740	COG0564	pseudouridine synthase activity
G8B45_RS03770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8B45_RS03775	COG1136	(ABC) transporter
G8B45_RS03780	COG0577	efflux transmembrane transporter activity
G8B45_RS03785	COG0584	glycerophosphoryl diester phosphodiesterase
G8B45_RS03795	COG1837	Belongs to the UPF0109 family
G8B45_RS03850	COG1349	DNA-binding transcription factor activity
G8B45_RS03855	COG1105	Belongs to the carbohydrate kinase PfkB family
G8B45_RS03860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8B45_RS03860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8B45_RS03860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8B45_RS03865	COG1388	LysM domain
G8B45_RS03865	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B45_RS03870	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B45_RS03870	COG1388	LysM domain
G8B45_RS03890	COG0105	UTP biosynthetic process
G8B45_RS03910	COG0488	(ABC) transporter
G8B45_RS03915	COG0242	peptide deformylase activity
G8B45_RS03920	COG0737	Belongs to the 5'-nucleotidase family
G8B45_RS03925	COG2357	RelA SpoT domain protein
G8B45_RS03930	COG0745	RESPONSE REGULATOR receiver
G8B45_RS03965	COG3425	synthase
G8B45_RS03975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G8B45_RS04035	COG0583	DNA-binding transcription factor activity
G8B45_RS04060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B45_RS04065	COG0765	amino acid transport
G8B45_RS04085	COG0187	DNA topoisomerase II activity
G8B45_RS04095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8B45_RS04120	COG0539	negative regulation of cytoplasmic translation
G8B45_RS04165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8B45_RS04170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G8B45_RS04180	COG0300	oxidoreductase activity
G8B45_RS04185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G8B45_RS04185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8B45_RS04200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8B45_RS04205	COG2384	SAM-dependent methyltransferase
G8B45_RS04215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8B45_RS04220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G8B45_RS04230	COG1088	dTDP-glucose 4,6-dehydratase activity
G8B45_RS04235	COG0582	viral genome integration into host DNA
G8B45_RS04370	COG1051	belongs to the nudix hydrolase family
G8B45_RS04375	COG0628	permease
G8B45_RS04380	COG0457	Tetratricopeptide repeat
G8B45_RS04385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G8B45_RS04400	COG1129	ABC transporter
G8B45_RS04420	COG0488	(ABC) transporter
G8B45_RS04425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G8B45_RS04430	COG0022	dehydrogenase e1 component
G8B45_RS04430	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8B45_RS04435	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8B45_RS04445	COG5492	domain, Protein
G8B45_RS04450	COG0095	Lipoate-protein ligase
G8B45_RS04455	COG3442	glutamine amidotransferase
G8B45_RS04460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8B45_RS04465	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G8B45_RS04485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8B45_RS04495	COG0647	UMP catabolic process
G8B45_RS04510	COG1518	maintenance of DNA repeat elements
G8B45_RS04515	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G8B45_RS04560	COG3715	PTS system
G8B45_RS04565	COG3716	PTS system mannose fructose sorbose family IID component
G8B45_RS04570	COG2972	Histidine kinase
G8B45_RS04575	COG2207	Transcriptional regulator
G8B45_RS04575	COG4753	response regulator
G8B45_RS04585	COG1012	belongs to the aldehyde dehydrogenase family
G8B45_RS04600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8B45_RS04675	COG1131	(ABC) transporter
G8B45_RS04690	COG1396	sequence-specific DNA binding
G8B45_RS04720	COG0285	dihydrofolate synthase activity
G8B45_RS04740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8B45_RS04755	COG1176	ABC-type spermidine putrescine transport system, permease component I
G8B45_RS04760	COG1177	transmembrane transport
G8B45_RS04770	COG4565	transcriptional regulatory protein
G8B45_RS04775	COG3290	protein histidine kinase activity
G8B45_RS04780	COG3493	citrate carrier protein
G8B45_RS04795	COG3700	Belongs to the class B bacterial acid phosphatase family
G8B45_RS04800	COG0038	chloride channel
G8B45_RS04810	COG0628	permease
G8B45_RS04820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G8B45_RS04835	COG1104	cysteine desulfurase activity
G8B45_RS04850	COG2357	RelA SpoT domain protein
G8B45_RS04860	COG0564	pseudouridine synthase activity
G8B45_RS04865	COG0280	phosphate acetyltransferase
G8B45_RS04870	COG4221	oxidoreductase activity
G8B45_RS04885	COG1174	glycine betaine transport
G8B45_RS04900	COG2233	PERMEase
G8B45_RS04925	COG2890	protein-(glutamine-N5) methyltransferase activity
G8B45_RS04955	COG1132	(ABC) transporter
G8B45_RS04960	COG1132	(ABC) transporter
G8B45_RS04980	COG3764	Sortase (surface protein transpeptidase)
G8B45_RS04985	COG0346	lactoylglutathione lyase activity
G8B45_RS05000	COG1272	protein, Hemolysin III
G8B45_RS05020	COG0758	DNA mediated transformation
G8B45_RS05025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8B45_RS05070	COG0511	ligase activity, forming carbon-carbon bonds
G8B45_RS05075	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
G8B45_RS05090	COG2851	Citrate transporter
G8B45_RS05100	COG0511	ligase activity, forming carbon-carbon bonds
G8B45_RS05105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
G8B45_RS05135	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
G8B45_RS05155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8B45_RS05165	COG2188	Transcriptional regulator
G8B45_RS05185	COG0488	(ABC) transporter
G8B45_RS05195	COG0351	phosphomethylpyrimidine kinase
G8B45_RS05195	COG0352	thiamine-phosphate diphosphorylase activity
G8B45_RS05200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8B45_RS05205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8B45_RS05205	COG1328	CTP reductase activity
G8B45_RS05210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8B45_RS05240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8B45_RS05250	COG0095	Lipoate-protein ligase
G8B45_RS05260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8B45_RS05265	COG4684	Psort location CytoplasmicMembrane, score
G8B45_RS05270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8B45_RS05275	COG1079	Belongs to the binding-protein-dependent transport system permease family
G8B45_RS05280	COG4603	Belongs to the binding-protein-dependent transport system permease family
G8B45_RS05285	COG3845	ABC transporter
G8B45_RS05290	COG1744	ABC transporter substrate-binding protein PnrA-like
G8B45_RS05295	COG0295	cytidine deaminase activity
G8B45_RS05300	COG2813	Specifically methylates the guanine in position
G8B45_RS05315	COG5002	protein histidine kinase activity
G8B45_RS05320	COG0745	RESPONSE REGULATOR receiver
G8B45_RS05330	COG0704	Plays a role in the regulation of phosphate uptake
G8B45_RS05345	COG0581	inorganic phosphate transmembrane transporter activity
G8B45_RS05350	COG0573	inorganic phosphate transmembrane transporter activity
G8B45_RS05360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
G8B45_RS05360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8B45_RS05365	COG0483	inositol monophosphate 1-phosphatase activity
G8B45_RS05380	COG0196	riboflavin kinase activity
G8B45_RS05410	COG1136	(ABC) transporter
G8B45_RS05410	COG4591	ABC-type transport system involved in lipoprotein release permease component
G8B45_RS05460	COG1115	amino acid carrier protein
G8B45_RS05465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G8B45_RS05475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B45_RS05480	COG1126	abc transporter atp-binding protein
G8B45_RS05485	COG0765	amino acid transport
G8B45_RS05490	COG2824	Alkylphosphonate utilization operon protein PhnA
G8B45_RS05505	COG0469	pyruvate kinase activity
G8B45_RS05520	COG1725	Transcriptional regulator
G8B45_RS05525	COG1131	(ABC) transporter
G8B45_RS05550	COG0058	SHG alpha-glucan phosphorylase activity
G8B45_RS05555	COG1640	4-alpha-glucanotransferase
G8B45_RS05560	COG1609	Transcriptional regulator
G8B45_RS05565	COG2182	Extracellular solute-binding protein
G8B45_RS05570	COG1175	transmembrane transport
G8B45_RS05575	COG3833	ABC-type maltose transport systems, permease component
G8B45_RS05590	COG3833	ABC-type maltose transport systems, permease component
G8B45_RS05595	COG1175	transmembrane transport
G8B45_RS05605	COG0366	Alpha amylase catalytic
G8B45_RS05610	COG2182	Extracellular solute-binding protein
G8B45_RS05615	COG0657	acetylesterase activity
G8B45_RS05620	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G8B45_RS05630	COG1696	Membrane protein involved in D-alanine export
G8B45_RS05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8B45_RS05655	COG1126	abc transporter atp-binding protein
G8B45_RS05665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B45_RS05675	COG1447	Phosphotransferase system cellobiose-specific component IIA
G8B45_RS05685	COG3711	transcriptional antiterminator
G8B45_RS05685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8B45_RS05695	COG2723	6-phospho-beta-galactosidase activity
G8B45_RS05725	COG0157	Belongs to the NadC ModD family
G8B45_RS05750	COG1187	pseudouridine synthase activity
G8B45_RS05760	COG2814	Major facilitator Superfamily
G8B45_RS05810	COG4109	DRTGG domain
G8B45_RS05815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8B45_RS05840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G8B45_RS05840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G8B45_RS05850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8B45_RS05855	COG1956	GAF domain-containing protein
G8B45_RS05875	COG0513	Belongs to the DEAD box helicase family
G8B45_RS05885	COG0726	polysaccharide deacetylase
G8B45_RS05905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8B45_RS05910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8B45_RS05945	COG1476	TRANSCRIPTIONal
G8B45_RS05960	COG4122	O-methyltransferase activity
G8B45_RS05965	COG2223	nitrite transmembrane transporter activity
G8B45_RS05980	COG1187	pseudouridine synthase activity
G8B45_RS06025	COG0658	competence protein
G8B45_RS06025	COG2333	competence protein COMEC
G8B45_RS06030	COG1596	polysaccharide export
G8B45_RS06030	COG1555	photosystem II stabilization
G8B45_RS06035	COG0204	Acyl-transferase
G8B45_RS06040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G8B45_RS06055	COG0513	Belongs to the DEAD box helicase family
G8B45_RS06070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8B45_RS06085	COG2116	formate transmembrane transporter activity
G8B45_RS06095	COG1827	regulation of RNA biosynthetic process
G8B45_RS06115	COG2217	Heavy metal translocating P-type atpase
G8B45_RS06130	COG3177	Filamentation induced by cAMP protein fic
G8B45_RS06285	COG3723	Recombinational DNA repair protein, rece pathway
G8B45_RS06330	COG2755	lipolytic protein G-D-S-L family
G8B45_RS06345	COG0497	DNA recombination
G8B45_RS06350	COG1438	arginine binding
G8B45_RS06355	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G8B45_RS06380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8B45_RS06385	COG0415	Belongs to the DNA photolyase family
G8B45_RS06395	COG0765	amino acid transport
G8B45_RS06400	COG4703	Protein of unknown function (DUF1797)
G8B45_RS06405	COG0542	response to heat
G8B45_RS06410	COG0494	nUDIX hydrolase
G8B45_RS06425	COG3599	regulation of cell shape
G8B45_RS06430	COG2302	S4 RNA-binding domain
G8B45_RS06445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G8B45_RS06480	COG1217	gtp-binding protein TYPA
G8B45_RS06485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8B45_RS06490	COG1940	carbohydrate kinase activity
G8B45_RS06500	COG0783	Belongs to the Dps family
G8B45_RS06515	COG4470	Protein conserved in bacteria
G8B45_RS06520	COG1609	Transcriptional regulator
G8B45_RS06525	COG3480	Lon protease (S16) C-terminal proteolytic domain
G8B45_RS06535	COG0742	ribosomal rna small subunit methyltransferase
G8B45_RS06545	COG0549	Belongs to the carbamate kinase family
G8B45_RS06550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8B45_RS06555	COG1288	antiporter activity
G8B45_RS06565	COG0454	-acetyltransferase
G8B45_RS06570	COG2235	arginine
G8B45_RS06595	COG2972	Histidine kinase
G8B45_RS06610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8B45_RS06615	COG0785	Cytochrome C biogenesis protein
G8B45_RS06620	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G8B45_RS06625	COG1518	maintenance of DNA repeat elements
G8B45_RS06685	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G8B45_RS06685	COG1605	Chorismate mutase
G8B45_RS06705	COG2226	methyltransferase
G8B45_RS06715	COG3250	beta-galactosidase activity
G8B45_RS06720	COG2207	Transcriptional regulator
G8B45_RS06720	COG4753	response regulator
G8B45_RS06725	COG2972	Histidine kinase
G8B45_RS06735	COG1653	transport
G8B45_RS06740	COG0395	ABC-type sugar transport system, permease component
G8B45_RS06745	COG1175	transmembrane transport
G8B45_RS06750	COG1940	carbohydrate kinase activity
G8B45_RS06755	COG2723	6-phospho-beta-galactosidase activity
G8B45_RS06760	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G8B45_RS06775	COG0383	alpha-mannosidase activity
G8B45_RS06870	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G8B45_RS06875	COG1739	Uncharacterized protein family UPF0029
G8B45_RS06885	COG1098	S1 RNA binding domain
G8B45_RS06895	COG2197	response regulator
G8B45_RS06900	COG4585	Histidine kinase
G8B45_RS06910	COG2815	serine threonine protein kinase
G8B45_RS06910	COG0515	serine threonine protein kinase
G8B45_RS06920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8B45_RS06920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8B45_RS06930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8B45_RS06950	COG0583	DNA-binding transcription factor activity
G8B45_RS06955	COG0183	Belongs to the thiolase family
G8B45_RS06960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8B45_RS06970	COG1028	Short-chain dehydrogenase reductase Sdr
G8B45_RS06975	COG2610	gluconate transmembrane transporter activity
G8B45_RS06990	COG0116	Belongs to the methyltransferase superfamily
G8B45_RS07015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8B45_RS07020	COG3579	cysteine-type endopeptidase activity
G8B45_RS07030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G8B45_RS07035	COG1113	amino acid transport
G8B45_RS07040	COG0492	ferredoxin-NADP+ reductase activity
G8B45_RS07050	COG1126	abc transporter atp-binding protein
G8B45_RS07060	COG0513	Belongs to the DEAD box helicase family
G8B45_RS07070	COG0768	penicillin binding
G8B45_RS07105	COG1131	(ABC) transporter
G8B45_RS07130	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8B45_RS07135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8B45_RS07170	COG1755	Isoprenylcysteine carboxyl methyltransferase
G8B45_RS07175	COG0656	L-ascorbic acid biosynthetic process
G8B45_RS07185	COG1283	sodium-dependent phosphate transmembrane transporter activity
G8B45_RS07205	COG0561	phosphatase activity
G8B45_RS07210	COG2860	membrane
G8B45_RS07220	COG1105	Belongs to the carbohydrate kinase PfkB family
G8B45_RS07260	COG2217	Heavy metal translocating P-type atpase
G8B45_RS07290	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G8B45_RS07295	COG0195	Participates in both transcription termination and antitermination
G8B45_RS07320	COG4473	ABC transporter
G8B45_RS07325	COG1131	(ABC) transporter
G8B45_RS07330	COG0537	adenosine 5'-monophosphoramidase activity
G8B45_RS07340	COG1316	TRANSCRIPTIONal
G8B45_RS07350	COG0802	atpase or kinase
G8B45_RS07355	COG2252	PERMEase
G8B45_RS07360	COG0561	phosphatase activity
G8B45_RS07370	COG3715	PTS system
G8B45_RS07375	COG3716	PTS system mannose fructose sorbose family IID component
G8B45_RS07400	COG0439	Biotin carboxylase
G8B45_RS07415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8B45_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
G8B45_RS07425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8B45_RS07450	COG1024	Enoyl-CoA hydratase
G8B45_RS07455	COG0484	heat shock protein binding
G8B45_RS07485	COG0588	phosphoglycerate mutase activity
G8B45_RS07490	COG2261	transglycosylase associated protein
G8B45_RS07520	COG1335	isochorismatase
G8B45_RS07530	COG0436	Aminotransferase
G8B45_RS07540	COG0561	phosphatase activity
G8B45_RS07545	COG0252	asparaginase activity
G8B45_RS07560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8B45_RS07565	COG1129	ABC transporter
G8B45_RS07580	COG1132	(ABC) transporter
G8B45_RS07585	COG4988	ABC transporter
G8B45_RS07590	COG1120	ATPase activity
G8B45_RS07615	COG1388	LysM domain
G8B45_RS07615	COG3942	CHAP domain
G8B45_RS07640	COG1482	cell wall glycoprotein biosynthetic process
G8B45_RS07645	COG1940	carbohydrate kinase activity
G8B45_RS07655	COG1263	PTS System
G8B45_RS07655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B45_RS07655	COG2190	(PTS) system
G8B45_RS07660	COG1621	beta-fructofuranosidase activity
G8B45_RS07665	COG1609	Transcriptional regulator
G8B45_RS07685	COG2131	deaminase
G8B45_RS07690	COG0006	proline dipeptidase activity
G8B45_RS07730	COG1194	a g-specific adenine glycosylase
G8B45_RS07735	COG3620	sequence-specific DNA binding
G8B45_RS07740	COG3118	belongs to the thioredoxin family
G8B45_RS07770	COG0681	Belongs to the peptidase S26 family
G8B45_RS07775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8B45_RS07790	COG1882	Formate acetyltransferase
G8B45_RS07795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G8B45_RS07810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8B45_RS07815	COG2814	Major facilitator Superfamily
G8B45_RS07820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8B45_RS07845	COG0789	Transcriptional regulator
G8B45_RS07860	COG2081	HI0933 family
G8B45_RS07870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G8B45_RS07875	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
G8B45_RS07895	COG0456	acetyltransferase
G8B45_RS07900	COG1214	PFAM Peptidase M22, glycoprotease
G8B45_RS07915	COG0174	glutamine synthetase
G8B45_RS07920	COG0789	Transcriptional regulator
G8B45_RS07935	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G8B45_RS07990	COG0668	transmembrane transport
G8B45_RS08000	COG4720	Psort location CytoplasmicMembrane, score
G8B45_RS08005	COG0351	phosphomethylpyrimidine kinase
G8B45_RS08050	COG1929	Belongs to the glycerate kinase type-1 family
G8B45_RS08055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G8B45_RS08080	COG0577	efflux transmembrane transporter activity
G8B45_RS08085	COG1136	(ABC) transporter
G8B45_RS08090	COG2274	protein secretion by the type I secretion system
G8B45_RS08110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B45_RS08110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B45_RS08115	COG1447	Phosphotransferase system cellobiose-specific component IIA
G8B45_RS08165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8B45_RS08170	COG1476	TRANSCRIPTIONal
G8B45_RS08190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8B45_RS08200	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G8B45_RS08215	COG1045	serine acetyltransferase
G8B45_RS08230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8B45_RS08245	COG3711	transcriptional antiterminator
G8B45_RS08270	COG0431	NADPH-dependent FMN reductase
G8B45_RS08275	COG1846	Transcriptional regulator
G8B45_RS08295	COG4589	Belongs to the CDS family
G8B45_RS08305	COG1862	Preprotein translocase
G8B45_RS08315	COG1523	belongs to the glycosyl hydrolase 13 family
G8B45_RS08325	COG3842	ATPase activity
G8B45_RS08370	COG1263	PTS System
G8B45_RS08370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B45_RS08370	COG2190	(PTS) system
G8B45_RS08375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8B45_RS08395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G8B45_RS08400	COG0512	Glutamine amidotransferase of anthranilate synthase
G8B45_RS08405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8B45_RS08445	COG0601	transmembrane transport
G8B45_RS08455	COG1122	ATPase activity
G8B45_RS08475	COG0803	Belongs to the bacterial solute-binding protein 9 family
G8B45_RS08500	COG3711	transcriptional antiterminator
G8B45_RS08510	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8B45_RS08510	COG3942	CHAP domain
G8B45_RS08515	COG2205	protein histidine kinase activity
G8B45_RS08520	COG0745	RESPONSE REGULATOR receiver
G8B45_RS08525	COG0577	efflux transmembrane transporter activity
G8B45_RS08530	COG1136	(ABC) transporter
G8B45_RS08595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8B45_RS08610	COG1882	Formate acetyltransferase
G8B45_RS08615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B45_RS08620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G8B45_RS08625	COG1447	Phosphotransferase system cellobiose-specific component IIA
G8B45_RS08630	COG2390	Transcriptional regulator
G8B45_RS08635	COG1349	DNA-binding transcription factor activity
G8B45_RS08640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G8B45_RS08655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8B45_RS08665	COG0564	pseudouridine synthase activity
G8B45_RS08695	COG0542	response to heat
G8B45_RS08700	COG4463	regulation of RNA biosynthetic process
G8B45_RS08715	COG0450	alkyl hydroperoxide reductase
G8B45_RS08730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G8B45_RS08740	COG3404	Formiminotransferase-cyclodeaminase
G8B45_RS08755	COG0531	amino acid
G8B45_RS08785	COG3590	peptidase
G8B45_RS08790	COG0366	Alpha amylase catalytic
G8B45_RS08795	COG1263	PTS System
G8B45_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8B45_RS08800	COG2188	Transcriptional regulator
G8B45_RS08805	COG1733	regulation of RNA biosynthetic process
G8B45_RS08810	COG2514	catechol 2,3-dioxygenase activity
G8B45_RS08820	COG0602	queuosine metabolic process
G8B45_RS08840	COG1328	CTP reductase activity
G8B45_RS08865	COG1393	Belongs to the ArsC family
G8B45_RS08880	COG0519	Catalyzes the synthesis of GMP from XMP
G8B45_RS08900	COG0582	viral genome integration into host DNA
G8B45_RS08915	COG1396	sequence-specific DNA binding
G8B45_RS08920	COG3617	BRO family, N-terminal domain
G8B45_RS08980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B45_RS08985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B45_RS08990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B45_RS09075	COG1511	domain protein
G8B45_RS09095	COG0305	Participates in initiation and elongation during chromosome replication
G8B45_RS09125	COG1760	l-serine dehydratase
G8B45_RS09130	COG1760	l-serine dehydratase
G8B45_RS09135	COG0741	lytic transglycosylase activity
G8B45_RS09140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G8B45_RS09155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8B45_RS09165	COG0612	Peptidase, M16
G8B45_RS09190	COG0517	IMP dehydrogenase activity
G8B45_RS09190	COG0516	GMP reductase activity
G8B45_RS09200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8B45_RS09205	COG0488	(ABC) transporter
G8B45_RS09240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8B45_RS09245	COG1475	DNA binding
G8B45_RS09295	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8B45_RS09390	COG0574	Belongs to the PEP-utilizing enzyme family
G8B45_RS09390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)