locus-tag	class	description
SPYM_RS00010	COG0592	DNA-directed DNA polymerase activity
SPYM_RS00020	COG0012	GTP binding
SPYM_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPYM_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPYM_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPYM_RS00065	COG0531	amino acid
SPYM_RS00235	COG3942	CHAP domain
SPYM_RS00255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPYM_RS00265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPYM_RS00280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SPYM_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPYM_RS00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPYM_RS00315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPYM_RS00330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPYM_RS00345	COG1012	belongs to the aldehyde dehydrogenase family
SPYM_RS00345	COG1454	alcohol dehydrogenase
SPYM_RS00350	COG1064	alcohol dehydrogenase
SPYM_RS00355	COG0534	Mate efflux family protein
SPYM_RS00470	COG0201	protein transport
SPYM_RS00605	COG1121	(ABC) transporter
SPYM_RS00610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPYM_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPYM_RS00650	COG1459	type II secretion system
SPYM_RS00655	COG4537	Required for transformation and DNA binding
SPYM_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPYM_RS00700	COG1363	Peptidase, m42
SPYM_RS00710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYM_RS00715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPYM_RS00730	COG1428	Deoxynucleoside kinase
SPYM_RS00735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPYM_RS00765	COG4509	Sortase family
SPYM_RS00790	COG2031	fatty acid transporter
SPYM_RS00805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYM_RS00820	COG0251	oxidation-reduction process
SPYM_RS00835	COG1269	ATP hydrolysis coupled proton transport
SPYM_RS00840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPYM_RS00850	COG1527	subunit (C
SPYM_RS00855	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SPYM_RS00890	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYM_RS00930	COG0626	cystathionine gamma-synthase activity
SPYM_RS00960	COG3623	hexulose-6-phosphate isomerase
SPYM_RS00980	COG4175	Glycine betaine
SPYM_RS00980	COG3448	diguanylate cyclase activity
SPYM_RS00990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYM_RS00990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPYM_RS01015	COG1268	BioY protein
SPYM_RS01020	COG1234	tRNA 3'-trailer cleavage
SPYM_RS01055	COG0457	Tetratricopeptide repeat
SPYM_RS01055	COG0705	Rhomboid family
SPYM_RS01075	COG1132	(ABC) transporter
SPYM_RS01080	COG1132	(ABC) transporter
SPYM_RS01090	COG0756	dUTP diphosphatase activity
SPYM_RS01115	COG3290	protein histidine kinase activity
SPYM_RS01140	COG1847	R3H domain protein
SPYM_RS01160	COG1175	transmembrane transport
SPYM_RS01165	COG0395	ABC-type sugar transport system, permease component
SPYM_RS01175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPYM_RS01190	COG0084	hydrolase, TatD family'
SPYM_RS01215	COG1564	THIamine pyrophosphokinase
SPYM_RS01230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPYM_RS01265	COG0765	amino acid transport
SPYM_RS01285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPYM_RS01295	COG0719	Fe-S assembly protein
SPYM_RS01300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SPYM_RS01315	COG1686	Belongs to the peptidase S11 family
SPYM_RS01320	COG1686	Belongs to the peptidase S11 family
SPYM_RS01325	COG4166	transmembrane transport
SPYM_RS01330	COG0601	transmembrane transport
SPYM_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPYM_RS01340	COG0444	Belongs to the ABC transporter superfamily
SPYM_RS01355	COG2801	Transposase and inactivated derivatives
SPYM_RS01360	COG2801	Transposase and inactivated derivatives
SPYM_RS01410	COG0351	phosphomethylpyrimidine kinase
SPYM_RS01415	COG4720	Psort location CytoplasmicMembrane, score
SPYM_RS01425	COG0668	transmembrane transport
SPYM_RS01480	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPYM_RS01495	COG0789	Transcriptional regulator
SPYM_RS01500	COG0174	glutamine synthetase
SPYM_RS01515	COG1214	PFAM Peptidase M22, glycoprotease
SPYM_RS01520	COG0456	acetyltransferase
SPYM_RS01540	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SPYM_RS01545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPYM_RS01555	COG2081	HI0933 family
SPYM_RS01570	COG0789	Transcriptional regulator
SPYM_RS01595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPYM_RS01600	COG2814	Major facilitator Superfamily
SPYM_RS01605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM_RS01620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPYM_RS01625	COG1882	Formate acetyltransferase
SPYM_RS01640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPYM_RS01645	COG0681	Belongs to the peptidase S26 family
SPYM_RS01675	COG3118	belongs to the thioredoxin family
SPYM_RS01680	COG3620	sequence-specific DNA binding
SPYM_RS01685	COG1194	a g-specific adenine glycosylase
SPYM_RS01725	COG0006	proline dipeptidase activity
SPYM_RS01730	COG2131	deaminase
SPYM_RS01750	COG1609	Transcriptional regulator
SPYM_RS01755	COG1621	beta-fructofuranosidase activity
SPYM_RS01760	COG1263	PTS System
SPYM_RS01760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM_RS01760	COG2190	(PTS) system
SPYM_RS01770	COG1940	carbohydrate kinase activity
SPYM_RS01775	COG1482	cell wall glycoprotein biosynthetic process
SPYM_RS01795	COG1388	LysM domain
SPYM_RS01795	COG3942	CHAP domain
SPYM_RS01825	COG4988	ABC transporter
SPYM_RS01830	COG1132	(ABC) transporter
SPYM_RS01845	COG1129	ABC transporter
SPYM_RS01850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SPYM_RS01865	COG0252	asparaginase activity
SPYM_RS01870	COG0561	phosphatase activity
SPYM_RS01880	COG0436	Aminotransferase
SPYM_RS01890	COG1335	isochorismatase
SPYM_RS01895	COG0574	Belongs to the PEP-utilizing enzyme family
SPYM_RS01895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPYM_RS01920	COG2261	transglycosylase associated protein
SPYM_RS01925	COG0588	phosphoglycerate mutase activity
SPYM_RS01960	COG1024	Enoyl-CoA hydratase
SPYM_RS01985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SPYM_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM_RS01995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SPYM_RS02010	COG0439	Biotin carboxylase
SPYM_RS02035	COG3716	PTS system mannose fructose sorbose family IID component
SPYM_RS02040	COG3715	PTS system
SPYM_RS02050	COG0561	phosphatase activity
SPYM_RS02055	COG2252	PERMEase
SPYM_RS02060	COG0802	atpase or kinase
SPYM_RS02070	COG1316	TRANSCRIPTIONal
SPYM_RS02080	COG0537	adenosine 5'-monophosphoramidase activity
SPYM_RS02085	COG1131	(ABC) transporter
SPYM_RS02090	COG4473	ABC transporter
SPYM_RS02115	COG0195	Participates in both transcription termination and antitermination
SPYM_RS02120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPYM_RS02150	COG2217	Heavy metal translocating P-type atpase
SPYM_RS02190	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYM_RS02200	COG2860	membrane
SPYM_RS02205	COG0561	phosphatase activity
SPYM_RS02225	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPYM_RS02235	COG0656	L-ascorbic acid biosynthetic process
SPYM_RS02240	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPYM_RS02275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM_RS02280	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPYM_RS02305	COG1131	(ABC) transporter
SPYM_RS02340	COG0768	penicillin binding
SPYM_RS02350	COG0513	Belongs to the DEAD box helicase family
SPYM_RS02360	COG1126	abc transporter atp-binding protein
SPYM_RS02370	COG0492	ferredoxin-NADP+ reductase activity
SPYM_RS02375	COG1113	amino acid transport
SPYM_RS02380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPYM_RS02390	COG3579	cysteine-type endopeptidase activity
SPYM_RS02395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM_RS02415	COG0116	Belongs to the methyltransferase superfamily
SPYM_RS02430	COG2610	gluconate transmembrane transporter activity
SPYM_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM_RS02445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SPYM_RS02450	COG0183	Belongs to the thiolase family
SPYM_RS02455	COG0583	DNA-binding transcription factor activity
SPYM_RS02475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPYM_RS02485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYM_RS02485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPYM_RS02495	COG2815	serine threonine protein kinase
SPYM_RS02495	COG0515	serine threonine protein kinase
SPYM_RS02505	COG4585	Histidine kinase
SPYM_RS02510	COG2197	response regulator
SPYM_RS02520	COG1098	S1 RNA binding domain
SPYM_RS02530	COG1739	Uncharacterized protein family UPF0029
SPYM_RS02535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPYM_RS02645	COG3561	AntA/AntB antirepressor
SPYM_RS02860	COG4824	toxin secretion phage lysis holin
SPYM_RS02870	COG1388	LysM domain
SPYM_RS02870	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPYM_RS02910	COG0383	alpha-mannosidase activity
SPYM_RS02925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SPYM_RS02930	COG2723	6-phospho-beta-galactosidase activity
SPYM_RS02935	COG1940	carbohydrate kinase activity
SPYM_RS02940	COG1175	transmembrane transport
SPYM_RS02945	COG0395	ABC-type sugar transport system, permease component
SPYM_RS02950	COG1653	transport
SPYM_RS02960	COG2972	Histidine kinase
SPYM_RS02965	COG2207	Transcriptional regulator
SPYM_RS02965	COG4753	response regulator
SPYM_RS02970	COG3250	beta-galactosidase activity
SPYM_RS02980	COG2226	methyltransferase
SPYM_RS03000	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPYM_RS03000	COG1605	Chorismate mutase
SPYM_RS03040	COG0673	inositol 2-dehydrogenase activity
SPYM_RS03050	COG0785	Cytochrome C biogenesis protein
SPYM_RS03055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPYM_RS03070	COG2972	Histidine kinase
SPYM_RS03110	COG1288	antiporter activity
SPYM_RS03115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYM_RS03120	COG0549	Belongs to the carbamate kinase family
SPYM_RS03130	COG0742	ribosomal rna small subunit methyltransferase
SPYM_RS03140	COG3480	Lon protease (S16) C-terminal proteolytic domain
SPYM_RS03145	COG1609	Transcriptional regulator
SPYM_RS03150	COG4470	Protein conserved in bacteria
SPYM_RS03165	COG0783	Belongs to the Dps family
SPYM_RS03175	COG1940	carbohydrate kinase activity
SPYM_RS03180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPYM_RS03185	COG1217	gtp-binding protein TYPA
SPYM_RS03220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPYM_RS03235	COG2302	S4 RNA-binding domain
SPYM_RS03240	COG3599	regulation of cell shape
SPYM_RS03255	COG0494	nUDIX hydrolase
SPYM_RS03260	COG0542	response to heat
SPYM_RS03265	COG4703	Protein of unknown function (DUF1797)
SPYM_RS03270	COG0765	amino acid transport
SPYM_RS03280	COG0415	Belongs to the DNA photolyase family
SPYM_RS03290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYM_RS03315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SPYM_RS03320	COG1438	arginine binding
SPYM_RS03325	COG0497	DNA recombination
SPYM_RS03340	COG2755	lipolytic protein G-D-S-L family
SPYM_RS03355	COG0582	viral genome integration into host DNA
SPYM_RS03370	COG1396	sequence-specific DNA binding
SPYM_RS03635	COG2217	Heavy metal translocating P-type atpase
SPYM_RS03650	COG1827	regulation of RNA biosynthetic process
SPYM_RS03660	COG2116	formate transmembrane transporter activity
SPYM_RS03680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYM_RS03695	COG0513	Belongs to the DEAD box helicase family
SPYM_RS03710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPYM_RS03715	COG0204	Acyl-transferase
SPYM_RS03720	COG1596	polysaccharide export
SPYM_RS03720	COG1555	photosystem II stabilization
SPYM_RS03725	COG0658	competence protein
SPYM_RS03725	COG2333	competence protein COMEC
SPYM_RS03770	COG1187	pseudouridine synthase activity
SPYM_RS03785	COG2223	nitrite transmembrane transporter activity
SPYM_RS03790	COG4122	O-methyltransferase activity
SPYM_RS03805	COG1476	TRANSCRIPTIONal
SPYM_RS03820	COG2801	Transposase and inactivated derivatives
SPYM_RS03825	COG2801	Transposase and inactivated derivatives
SPYM_RS03845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPYM_RS03850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SPYM_RS03870	COG0726	polysaccharide deacetylase
SPYM_RS03875	COG0513	Belongs to the DEAD box helicase family
SPYM_RS03895	COG1956	GAF domain-containing protein
SPYM_RS03900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPYM_RS03905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SPYM_RS03905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SPYM_RS03935	COG4109	DRTGG domain
SPYM_RS03985	COG2814	Major facilitator Superfamily
SPYM_RS03995	COG1187	pseudouridine synthase activity
SPYM_RS04005	COG2801	Transposase and inactivated derivatives
SPYM_RS04020	COG0157	Belongs to the NadC ModD family
SPYM_RS04025	COG2801	Transposase and inactivated derivatives
SPYM_RS04050	COG2723	6-phospho-beta-galactosidase activity
SPYM_RS04060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYM_RS04060	COG3711	transcriptional antiterminator
SPYM_RS04070	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM_RS04080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM_RS04085	COG1126	abc transporter atp-binding protein
SPYM_RS04090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM_RS04110	COG1696	Membrane protein involved in D-alanine export
SPYM_RS04120	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPYM_RS04125	COG0657	acetylesterase activity
SPYM_RS04140	COG3833	ABC-type maltose transport systems, permease component
SPYM_RS04145	COG1175	transmembrane transport
SPYM_RS04150	COG2182	Extracellular solute-binding protein
SPYM_RS04155	COG1609	Transcriptional regulator
SPYM_RS04160	COG1640	4-alpha-glucanotransferase
SPYM_RS04165	COG0058	SHG alpha-glucan phosphorylase activity
SPYM_RS04185	COG1131	(ABC) transporter
SPYM_RS04190	COG1725	Transcriptional regulator
SPYM_RS04205	COG0469	pyruvate kinase activity
SPYM_RS04220	COG2824	Alkylphosphonate utilization operon protein PhnA
SPYM_RS04225	COG0765	amino acid transport
SPYM_RS04230	COG1126	abc transporter atp-binding protein
SPYM_RS04235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM_RS04245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPYM_RS04250	COG1115	amino acid carrier protein
SPYM_RS04300	COG1136	(ABC) transporter
SPYM_RS04300	COG4591	ABC-type transport system involved in lipoprotein release permease component
SPYM_RS04330	COG0196	riboflavin kinase activity
SPYM_RS04345	COG0483	inositol monophosphate 1-phosphatase activity
SPYM_RS04350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPYM_RS04350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SPYM_RS04360	COG0573	inorganic phosphate transmembrane transporter activity
SPYM_RS04365	COG0581	inorganic phosphate transmembrane transporter activity
SPYM_RS04380	COG0704	Plays a role in the regulation of phosphate uptake
SPYM_RS04390	COG0745	RESPONSE REGULATOR receiver
SPYM_RS04395	COG5002	protein histidine kinase activity
SPYM_RS04410	COG2813	Specifically methylates the guanine in position
SPYM_RS04415	COG0295	cytidine deaminase activity
SPYM_RS04420	COG1744	ABC transporter substrate-binding protein PnrA-like
SPYM_RS04425	COG3845	ABC transporter
SPYM_RS04430	COG4603	Belongs to the binding-protein-dependent transport system permease family
SPYM_RS04435	COG1079	Belongs to the binding-protein-dependent transport system permease family
SPYM_RS04440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPYM_RS04445	COG4684	Psort location CytoplasmicMembrane, score
SPYM_RS04450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPYM_RS04470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPYM_RS04500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPYM_RS04505	COG1328	CTP reductase activity
SPYM_RS04505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SPYM_RS04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPYM_RS04515	COG0352	thiamine-phosphate diphosphorylase activity
SPYM_RS04515	COG0351	phosphomethylpyrimidine kinase
SPYM_RS04525	COG0488	(ABC) transporter
SPYM_RS04545	COG2188	Transcriptional regulator
SPYM_RS04555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPYM_RS04575	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SPYM_RS04610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYM_RS04615	COG0511	ligase activity, forming carbon-carbon bonds
SPYM_RS04625	COG2851	Citrate transporter
SPYM_RS04640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SPYM_RS04645	COG0511	ligase activity, forming carbon-carbon bonds
SPYM_RS04665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPYM_RS04670	COG0758	DNA mediated transformation
SPYM_RS04690	COG1272	protein, Hemolysin III
SPYM_RS04705	COG0346	lactoylglutathione lyase activity
SPYM_RS04710	COG3764	Sortase (surface protein transpeptidase)
SPYM_RS04730	COG1132	(ABC) transporter
SPYM_RS04735	COG1132	(ABC) transporter
SPYM_RS04765	COG2890	protein-(glutamine-N5) methyltransferase activity
SPYM_RS04790	COG2233	PERMEase
SPYM_RS04805	COG1174	glycine betaine transport
SPYM_RS04820	COG4221	oxidoreductase activity
SPYM_RS04825	COG0280	phosphate acetyltransferase
SPYM_RS04830	COG0564	pseudouridine synthase activity
SPYM_RS04840	COG2357	RelA SpoT domain protein
SPYM_RS04845	COG4116	CYTH
SPYM_RS04855	COG1104	cysteine desulfurase activity
SPYM_RS04870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPYM_RS04890	COG0038	chloride channel
SPYM_RS04895	COG3700	Belongs to the class B bacterial acid phosphatase family
SPYM_RS04910	COG3493	citrate carrier protein
SPYM_RS04915	COG3290	protein histidine kinase activity
SPYM_RS04920	COG4565	transcriptional regulatory protein
SPYM_RS04930	COG1177	transmembrane transport
SPYM_RS04935	COG1176	ABC-type spermidine putrescine transport system, permease component I
SPYM_RS04950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPYM_RS04970	COG0285	dihydrofolate synthase activity
SPYM_RS05005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPYM_RS05020	COG1012	belongs to the aldehyde dehydrogenase family
SPYM_RS05030	COG2207	Transcriptional regulator
SPYM_RS05030	COG4753	response regulator
SPYM_RS05035	COG2972	Histidine kinase
SPYM_RS05040	COG3716	PTS system mannose fructose sorbose family IID component
SPYM_RS05045	COG3715	PTS system
SPYM_RS05085	COG0647	UMP catabolic process
SPYM_RS05095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPYM_RS05115	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SPYM_RS05120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPYM_RS05125	COG3442	glutamine amidotransferase
SPYM_RS05130	COG0095	Lipoate-protein ligase
SPYM_RS05150	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYM_RS05155	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPYM_RS05155	COG0022	dehydrogenase e1 component
SPYM_RS05160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPYM_RS05165	COG0488	(ABC) transporter
SPYM_RS05185	COG1129	ABC transporter
SPYM_RS05200	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SPYM_RS05205	COG0457	Tetratricopeptide repeat
SPYM_RS05210	COG0628	permease
SPYM_RS05215	COG1051	belongs to the nudix hydrolase family
SPYM_RS05350	COG1783	phage Terminase large subunit
SPYM_RS05450	COG0582	viral genome integration into host DNA
SPYM_RS05455	COG1088	dTDP-glucose 4,6-dehydratase activity
SPYM_RS05465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SPYM_RS05470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPYM_RS05480	COG2384	SAM-dependent methyltransferase
SPYM_RS05485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPYM_RS05500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPYM_RS05500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPYM_RS05505	COG0300	oxidoreductase activity
SPYM_RS05515	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPYM_RS05520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPYM_RS05555	COG0539	negative regulation of cytoplasmic translation
SPYM_RS05575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPYM_RS05590	COG0187	DNA topoisomerase II activity
SPYM_RS05610	COG0765	amino acid transport
SPYM_RS05640	COG0583	DNA-binding transcription factor activity
SPYM_RS05655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SPYM_RS05700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SPYM_RS05710	COG3425	synthase
SPYM_RS05745	COG0745	RESPONSE REGULATOR receiver
SPYM_RS05750	COG2357	RelA SpoT domain protein
SPYM_RS05755	COG0737	Belongs to the 5'-nucleotidase family
SPYM_RS05760	COG0242	peptide deformylase activity
SPYM_RS05770	COG0488	(ABC) transporter
SPYM_RS05790	COG0105	UTP biosynthetic process
SPYM_RS05810	COG1388	LysM domain
SPYM_RS05810	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM_RS05815	COG1388	LysM domain
SPYM_RS05815	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM_RS05820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYM_RS05820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPYM_RS05820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPYM_RS05825	COG1105	Belongs to the carbohydrate kinase PfkB family
SPYM_RS05830	COG1349	DNA-binding transcription factor activity
SPYM_RS05880	COG1837	Belongs to the UPF0109 family
SPYM_RS05890	COG0584	glycerophosphoryl diester phosphodiesterase
SPYM_RS05895	COG0577	efflux transmembrane transporter activity
SPYM_RS05900	COG1136	(ABC) transporter
SPYM_RS05905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SPYM_RS05935	COG0564	pseudouridine synthase activity
SPYM_RS05945	COG0583	DNA-binding transcription factor activity
SPYM_RS05950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SPYM_RS05975	COG1104	cysteine desulfurase activity
SPYM_RS05985	COG0285	dihydrofolate synthase activity
SPYM_RS05990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPYM_RS06010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPYM_RS06015	COG1368	sulfuric ester hydrolase activity
SPYM_RS06070	COG1216	Glycosyl transferase, family 2
SPYM_RS06115	COG2151	metal-sulfur cluster biosynthetic enzyme
SPYM_RS06120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPYM_RS06125	COG0358	DNA primase activity
SPYM_RS06130	COG1970	mechanosensitive ion channel activity
SPYM_RS06140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM_RS06155	COG2321	neutral zinc metallopeptidase
SPYM_RS06165	COG0577	efflux transmembrane transporter activity
SPYM_RS06250	COG1597	lipid kinase activity
SPYM_RS06260	COG4708	membrane
SPYM_RS06280	COG1131	(ABC) transporter
SPYM_RS06350	COG0038	chloride channel
SPYM_RS06360	COG0716	FMN binding
SPYM_RS06365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPYM_RS06375	COG2222	sugar isomerase
SPYM_RS06380	COG2188	Transcriptional regulator
SPYM_RS06405	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM_RS06500	COG0740	serine-type endopeptidase activity
SPYM_RS06540	COG1598	PFAM Uncharacterised protein family UPF0150
SPYM_RS06615	COG3723	Recombinational DNA repair protein, rece pathway
SPYM_RS06670	COG3620	sequence-specific DNA binding
SPYM_RS06705	COG0436	Aminotransferase
SPYM_RS06710	COG1199	ATP-dependent helicase activity
SPYM_RS06710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SPYM_RS06725	COG2177	Part of the ABC transporter FtsEX involved in
SPYM_RS06730	COG2884	Cell division ATP-binding protein ftsE
SPYM_RS06740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPYM_RS06745	COG0546	phosphoglycolate phosphatase activity
SPYM_RS06750	COG0800	Aldolase
SPYM_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM_RS06780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM_RS06785	COG3715	PTS system
SPYM_RS06790	COG3716	PTS system mannose fructose sorbose family IID component
SPYM_RS06800	COG1609	Transcriptional regulator
SPYM_RS06815	COG1078	dGTPase activity
SPYM_RS06850	COG0772	Belongs to the SEDS family
SPYM_RS06860	COG1164	Oligoendopeptidase f
SPYM_RS06865	COG0386	Belongs to the glutathione peroxidase family
SPYM_RS06915	COG4443	Transcriptional Coactivator p15 (PC4)
SPYM_RS06920	COG0826	peptidase U32
SPYM_RS06965	COG2183	response to ionizing radiation
SPYM_RS06975	COG0701	Predicted permease
SPYM_RS06980	COG3689	TIGRFAM TIGR03943 family protein
SPYM_RS06990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM_RS06990	COG2190	(PTS) system
SPYM_RS06990	COG1263	PTS System
SPYM_RS06995	COG3711	transcriptional antiterminator
SPYM_RS07000	COG0477	Major facilitator Superfamily
SPYM_RS07005	COG0552	protein localization to endoplasmic reticulum
SPYM_RS07010	COG0561	phosphatase activity
SPYM_RS07015	COG0561	phosphatase activity
SPYM_RS07070	COG4695	Portal protein
SPYM_RS07160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPYM_RS07170	COG1196	nuclear chromosome segregation
SPYM_RS07180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPYM_RS07185	COG5002	protein histidine kinase activity
SPYM_RS07190	COG0745	RESPONSE REGULATOR receiver
SPYM_RS07205	COG0183	Belongs to the thiolase family
SPYM_RS07215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPYM_RS07220	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPYM_RS07225	COG1461	Dihydroxyacetone kinase
SPYM_RS07230	COG2376	Dihydroxyacetone kinase
SPYM_RS07240	COG2376	Dihydroxyacetone kinase
SPYM_RS07255	COG4555	ABC transporter
SPYM_RS07265	COG0438	transferase activity, transferring glycosyl groups
SPYM_RS07275	COG1609	Transcriptional regulator
SPYM_RS07280	COG0006	proline dipeptidase activity
SPYM_RS07285	COG0778	Nitroreductase
SPYM_RS07295	COG0463	Glycosyl transferase, family 2
SPYM_RS07325	COG0557	exoribonuclease II activity
SPYM_RS07335	COG2814	Major facilitator Superfamily
SPYM_RS07340	COG0433	COG0433 Predicted ATPase
SPYM_RS07405	COG3328	transposase activity
SPYM_RS07430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPYM_RS07440	COG1573	uracil-dna glycosylase
SPYM_RS07445	COG1702	phosphate starvation-inducible protein PhoH
SPYM_RS07530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPYM_RS07555	COG0673	inositol 2-dehydrogenase activity
SPYM_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
SPYM_RS07620	COG1304	FMN binding
SPYM_RS07630	COG0708	Exodeoxyribonuclease III
SPYM_RS07635	COG1393	Belongs to the ArsC family
SPYM_RS07665	COG0470	DNA polymerase III
SPYM_RS07690	COG2244	polysaccharide biosynthetic process
SPYM_RS07700	COG1120	ATPase activity
SPYM_RS07705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPYM_RS07710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYM_RS07715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPYM_RS07730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYM_RS07735	COG1253	flavin adenine dinucleotide binding
SPYM_RS07740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPYM_RS07745	COG1242	4 iron, 4 sulfur cluster binding
SPYM_RS07750	COG0671	phosphoesterase, PA-phosphatase related
SPYM_RS07755	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SPYM_RS07770	COG1187	pseudouridine synthase activity
SPYM_RS07825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYM_RS07830	COG1254	Belongs to the acylphosphatase family
SPYM_RS07845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SPYM_RS07865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SPYM_RS07875	COG1484	DNA-dependent DNA replication
SPYM_RS07895	COG0745	RESPONSE REGULATOR receiver
SPYM_RS07910	COG1704	LemA family
SPYM_RS07920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPYM_RS07925	COG0569	domain protein
SPYM_RS07935	COG1114	Component of the transport system for branched-chain amino acids
SPYM_RS07950	COG1464	Belongs to the NlpA lipoprotein family
SPYM_RS07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SPYM_RS07970	COG2226	methyltransferase
SPYM_RS07975	COG0799	negative regulation of ribosome biogenesis
SPYM_RS07980	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPYM_RS07990	COG1534	Rna-binding protein
SPYM_RS07995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPYM_RS08000	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPYM_RS08040	COG1929	Belongs to the glycerate kinase type-1 family
SPYM_RS08045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPYM_RS08075	COG0577	efflux transmembrane transporter activity
SPYM_RS08080	COG1136	(ABC) transporter
SPYM_RS08085	COG2274	protein secretion by the type I secretion system
SPYM_RS08100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM_RS08100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM_RS08105	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM_RS08155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPYM_RS08160	COG1476	TRANSCRIPTIONal
SPYM_RS08180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPYM_RS08190	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPYM_RS08210	COG1045	serine acetyltransferase
SPYM_RS08225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPYM_RS08240	COG3711	transcriptional antiterminator
SPYM_RS08265	COG1846	Transcriptional regulator
SPYM_RS08285	COG4589	Belongs to the CDS family
SPYM_RS08295	COG1862	Preprotein translocase
SPYM_RS08305	COG1523	belongs to the glycosyl hydrolase 13 family
SPYM_RS08315	COG3842	ATPase activity
SPYM_RS08355	COG2190	(PTS) system
SPYM_RS08355	COG1263	PTS System
SPYM_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM_RS08360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPYM_RS08380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPYM_RS08385	COG0512	Glutamine amidotransferase of anthranilate synthase
SPYM_RS08390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPYM_RS08420	COG0601	transmembrane transport
SPYM_RS08430	COG1122	ATPase activity
SPYM_RS08450	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPYM_RS08470	COG3711	transcriptional antiterminator
SPYM_RS08480	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPYM_RS08480	COG3942	CHAP domain
SPYM_RS08485	COG2205	protein histidine kinase activity
SPYM_RS08490	COG0745	RESPONSE REGULATOR receiver
SPYM_RS08495	COG0577	efflux transmembrane transporter activity
SPYM_RS08500	COG1136	(ABC) transporter
SPYM_RS08550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SPYM_RS08565	COG1882	Formate acetyltransferase
SPYM_RS08570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM_RS08575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPYM_RS08580	COG1447	Phosphotransferase system cellobiose-specific component IIA
SPYM_RS08585	COG2390	Transcriptional regulator
SPYM_RS08590	COG1349	DNA-binding transcription factor activity
SPYM_RS08595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPYM_RS08605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPYM_RS08620	COG0564	pseudouridine synthase activity
SPYM_RS08650	COG0542	response to heat
SPYM_RS08655	COG4463	regulation of RNA biosynthetic process
SPYM_RS08670	COG0450	alkyl hydroperoxide reductase
SPYM_RS08685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPYM_RS08695	COG3404	Formiminotransferase-cyclodeaminase
SPYM_RS08710	COG0531	amino acid
SPYM_RS08745	COG3590	peptidase
SPYM_RS08750	COG0366	Alpha amylase catalytic
SPYM_RS08755	COG1263	PTS System
SPYM_RS08755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPYM_RS08760	COG2188	Transcriptional regulator
SPYM_RS08765	COG1733	regulation of RNA biosynthetic process
SPYM_RS08770	COG2514	catechol 2,3-dioxygenase activity
SPYM_RS08780	COG0602	queuosine metabolic process
SPYM_RS08795	COG1328	CTP reductase activity
SPYM_RS08820	COG1393	Belongs to the ArsC family
SPYM_RS08835	COG0519	Catalyzes the synthesis of GMP from XMP
SPYM_RS08970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM_RS08975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM_RS08980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM_RS09060	COG1511	domain protein
SPYM_RS09080	COG0305	Participates in initiation and elongation during chromosome replication
SPYM_RS09110	COG1760	l-serine dehydratase
SPYM_RS09115	COG1760	l-serine dehydratase
SPYM_RS09120	COG0741	lytic transglycosylase activity
SPYM_RS09125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SPYM_RS09140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SPYM_RS09150	COG0612	Peptidase, M16
SPYM_RS09155	COG0612	Peptidase, M16
SPYM_RS09170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SPYM_RS09195	COG0517	IMP dehydrogenase activity
SPYM_RS09195	COG0516	GMP reductase activity
SPYM_RS09205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPYM_RS09210	COG0488	(ABC) transporter
SPYM_RS09245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPYM_RS09250	COG1475	DNA binding
SPYM_RS09265	COG2801	Transposase and inactivated derivatives