locus-tag	class	description
CHF41_RS00025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CHF41_RS00035	COG0037	tRNA processing
CHF41_RS00055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CHF41_RS00060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHF41_RS00065	COG0193	aminoacyl-tRNA hydrolase activity
CHF41_RS00070	COG0012	GTP binding
CHF41_RS00090	COG0592	DNA-directed DNA polymerase activity
CHF41_RS00100	COG1475	DNA binding
CHF41_RS00105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHF41_RS00110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CHF41_RS00140	COG0488	(ABC) transporter
CHF41_RS00145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHF41_RS00150	COG0180	Tryptophanyl-tRNA synthetase
CHF41_RS00155	COG0517	IMP dehydrogenase activity
CHF41_RS00155	COG0516	GMP reductase activity
CHF41_RS00165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHF41_RS00170	COG2501	S4 domain
CHF41_RS00175	COG0612	Peptidase, M16
CHF41_RS00180	COG0612	Peptidase, M16
CHF41_RS00185	COG1426	Protein conserved in bacteria
CHF41_RS00190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHF41_RS00195	COG1122	ATPase activity
CHF41_RS00200	COG1122	ATPase activity
CHF41_RS00205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CHF41_RS00215	COG0406	alpha-ribazole phosphatase activity
CHF41_RS00220	COG1760	l-serine dehydratase
CHF41_RS00225	COG1760	l-serine dehydratase
CHF41_RS00230	COG0482	sulfurtransferase activity
CHF41_RS00235	COG0494	nUDIX hydrolase
CHF41_RS00240	COG0445	tRNA wobble uridine modification
CHF41_RS00250	COG0359	binds to the 23S rRNA
CHF41_RS00255	COG0305	Participates in initiation and elongation during chromosome replication
CHF41_RS00265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS00265	COG1263	PTS System
CHF41_RS00270	COG1486	melibiose metabolic process
CHF41_RS00275	COG1737	Transcriptional regulator
CHF41_RS00285	COG1053	succinate dehydrogenase
CHF41_RS00305	COG1472	Belongs to the glycosyl hydrolase 3 family
CHF41_RS00315	COG1472	Belongs to the glycosyl hydrolase 3 family
CHF41_RS00320	COG1216	Glycosyl transferase, family 2
CHF41_RS00325	COG4989	oxidoreductase activity
CHF41_RS00330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHF41_RS00335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHF41_RS00340	COG1780	Probably involved in ribonucleotide reductase function
CHF41_RS00345	COG1523	belongs to the glycosyl hydrolase 13 family
CHF41_RS00350	COG1609	Transcriptional regulator
CHF41_RS00355	COG5521	maltodextrose utilization protein MalA
CHF41_RS00360	COG3833	ABC-type maltose transport systems, permease component
CHF41_RS00365	COG1175	transmembrane transport
CHF41_RS00370	COG2182	Extracellular solute-binding protein
CHF41_RS00375	COG1640	4-alpha-glucanotransferase
CHF41_RS00385	COG0018	arginyl-trna synthetase
CHF41_RS00390	COG1438	arginine binding
CHF41_RS00410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHF41_RS00420	COG0632	four-way junction helicase activity
CHF41_RS00425	COG2818	Glycosylase
CHF41_RS00440	COG1266	CAAX protease self-immunity
CHF41_RS00450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CHF41_RS00455	COG1393	Belongs to the ArsC family
CHF41_RS00460	COG4472	Bacterial protein of unknown function (DUF965)
CHF41_RS00465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CHF41_RS00470	COG3906	Belongs to the UPF0473 family
CHF41_RS00485	COG0285	dihydrofolate synthase activity
CHF41_RS00495	COG1328	CTP reductase activity
CHF41_RS00510	COG0562	UDP-galactopyranose mutase
CHF41_RS00525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CHF41_RS00545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CHF41_RS00560	COG1490	D-aminoacyl-tRNA deacylase activity
CHF41_RS00585	COG3590	peptidase
CHF41_RS00600	COG0626	cystathionine gamma-synthase activity
CHF41_RS00605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHF41_RS00610	COG0765	amino acid transport
CHF41_RS00615	COG1126	abc transporter atp-binding protein
CHF41_RS00675	COG3623	hexulose-6-phosphate isomerase
CHF41_RS00695	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CHF41_RS00710	COG3414	Phosphotransferase system galactitol-specific IIB component
CHF41_RS00715	COG3775	system Galactitol-specific IIC component
CHF41_RS00720	COG1063	alcohol dehydrogenase
CHF41_RS00730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CHF41_RS00750	COG3730	PTS system glucitol sorbitol-specific
CHF41_RS00755	COG3732	PTS system glucitol sorbitol-specific
CHF41_RS00790	COG1473	amidohydrolase
CHF41_RS00795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHF41_RS00800	COG0705	Rhomboid family
CHF41_RS00805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHF41_RS00810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHF41_RS00815	COG1132	(ABC) transporter
CHF41_RS00820	COG1132	(ABC) transporter
CHF41_RS00825	COG0756	dUTP diphosphatase activity
CHF41_RS00860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CHF41_RS00875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CHF41_RS00880	COG0594	ribonuclease P activity
CHF41_RS00895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CHF41_RS00900	COG0084	hydrolase, TatD family'
CHF41_RS00925	COG0667	Aldo Keto reductase
CHF41_RS00945	COG0395	ABC-type sugar transport system, permease component
CHF41_RS00970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHF41_RS00985	COG3718	enzyme involved in inositol metabolism
CHF41_RS00990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHF41_RS00995	COG3962	Belongs to the TPP enzyme family
CHF41_RS01000	COG1454	alcohol dehydrogenase
CHF41_RS01010	COG1162	GTPase activity
CHF41_RS01020	COG1564	THIamine pyrophosphokinase
CHF41_RS01030	COG3481	metal-dependent phosphohydrolase, HD sub domain
CHF41_RS01035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHF41_RS01040	COG0366	Alpha amylase catalytic
CHF41_RS01045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS01045	COG1263	PTS System
CHF41_RS01050	COG2188	Transcriptional regulator
CHF41_RS01065	COG1193	negative regulation of DNA recombination
CHF41_RS01075	COG3118	belongs to the thioredoxin family
CHF41_RS01085	COG2223	nitrite transmembrane transporter activity
CHF41_RS01100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CHF41_RS01110	COG2222	sugar isomerase
CHF41_RS01130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CHF41_RS01135	COG1882	Formate acetyltransferase
CHF41_RS01170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHF41_RS01175	COG0681	Belongs to the peptidase S26 family
CHF41_RS01190	COG0564	pseudouridine synthase activity
CHF41_RS01195	COG0492	ferredoxin-NADP+ reductase activity
CHF41_RS01200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHF41_RS01205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHF41_RS01235	COG0582	viral genome integration into host DNA
CHF41_RS01365	COG0582	viral genome integration into host DNA
CHF41_RS01495	COG0052	Belongs to the universal ribosomal protein uS2 family
CHF41_RS01500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CHF41_RS01510	COG4463	regulation of RNA biosynthetic process
CHF41_RS01515	COG0542	response to heat
CHF41_RS01520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHF41_RS01525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CHF41_RS01530	COG1105	Belongs to the carbohydrate kinase PfkB family
CHF41_RS01535	COG1349	DNA-binding transcription factor activity
CHF41_RS01540	COG2213	PTS system mannitol-specific
CHF41_RS01540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS01545	COG3414	Phosphotransferase system galactitol-specific IIB component
CHF41_RS01550	COG3775	system Galactitol-specific IIC component
CHF41_RS01565	COG0235	Class ii aldolase
CHF41_RS01570	COG2918	glutathione biosynthetic process
CHF41_RS01570	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHF41_RS01575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CHF41_RS01590	COG1304	FMN binding
CHF41_RS01600	COG3759	membrane
CHF41_RS01615	COG0383	alpha-mannosidase activity
CHF41_RS01630	COG4209	transmembrane transport
CHF41_RS01635	COG0395	ABC-type sugar transport system, permease component
CHF41_RS01640	COG1653	transport
CHF41_RS01650	COG2972	Histidine kinase
CHF41_RS01655	COG2207	Transcriptional regulator
CHF41_RS01655	COG4753	response regulator
CHF41_RS01660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CHF41_RS01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHF41_RS01680	COG1862	Preprotein translocase
CHF41_RS01685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CHF41_RS01690	COG4589	Belongs to the CDS family
CHF41_RS01695	COG0750	zinc metalloprotease
CHF41_RS01700	COG0442	prolyl-tRNA aminoacylation
CHF41_RS01720	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CHF41_RS01725	COG1461	Dihydroxyacetone kinase
CHF41_RS01730	COG2376	Dihydroxyacetone kinase
CHF41_RS01740	COG2376	Dihydroxyacetone kinase
CHF41_RS01745	COG2176	DNA-directed DNA polymerase activity
CHF41_RS01765	COG1174	glycine betaine transport
CHF41_RS01775	COG2309	aminopeptidase activity
CHF41_RS01790	COG0242	peptide deformylase activity
CHF41_RS01800	COG1187	pseudouridine synthase activity
CHF41_RS01810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHF41_RS01820	COG1045	serine acetyltransferase
CHF41_RS01825	COG0215	cysteine-tRNA ligase activity
CHF41_RS01830	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CHF41_RS01840	COG3842	ATPase activity
CHF41_RS01860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHF41_RS01875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHF41_RS01895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CHF41_RS01915	COG1373	ATPase (AAA superfamily
CHF41_RS01920	COG1929	Belongs to the glycerate kinase type-1 family
CHF41_RS01940	COG1129	ABC transporter
CHF41_RS01945	COG2860	membrane
CHF41_RS01950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CHF41_RS01955	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHF41_RS01955	COG0022	dehydrogenase e1 component
CHF41_RS01960	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHF41_RS01970	COG0095	Lipoate-protein ligase
CHF41_RS01980	COG4720	Psort location CytoplasmicMembrane, score
CHF41_RS01985	COG1054	Belongs to the UPF0176 family
CHF41_RS01995	COG1122	ATPase activity
CHF41_RS02005	COG0357	Ribosomal RNA small subunit methyltransferase G
CHF41_RS02010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHF41_RS02015	COG3331	DNA recombination
CHF41_RS02020	COG4474	Belongs to the UPF0398 family
CHF41_RS02025	COG3599	regulation of cell shape
CHF41_RS02035	COG0116	Belongs to the methyltransferase superfamily
CHF41_RS02045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHF41_RS02060	COG1854	S-ribosylhomocysteine lyase activity
CHF41_RS02065	COG1418	mRNA catabolic process
CHF41_RS02070	COG0194	GDP metabolic process
CHF41_RS02075	COG1758	RNA polymerase activity
CHF41_RS02080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHF41_RS02085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CHF41_RS02090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHF41_RS02090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHF41_RS02095	COG0631	protein serine/threonine phosphatase activity
CHF41_RS02100	COG0515	serine threonine protein kinase
CHF41_RS02100	COG2815	serine threonine protein kinase
CHF41_RS02110	COG4585	Histidine kinase
CHF41_RS02115	COG2197	response regulator
CHF41_RS02125	COG1185	polyribonucleotide nucleotidyltransferase activity
CHF41_RS02135	COG1739	Uncharacterized protein family UPF0029
CHF41_RS02140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CHF41_RS02145	COG1040	competence protein
CHF41_RS02275	COG3942	CHAP domain
CHF41_RS02280	COG0367	asparagine synthase
CHF41_RS02285	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHF41_RS02295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CHF41_RS02300	COG0436	Aminotransferase
CHF41_RS02305	COG1381	Involved in DNA repair and RecF pathway recombination
CHF41_RS02310	COG0416	fatty acid biosynthetic process
CHF41_RS02315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHF41_RS02325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHF41_RS02340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CHF41_RS02355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CHF41_RS02375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CHF41_RS02380	COG2255	four-way junction helicase activity
CHF41_RS02385	COG0546	phosphoglycolate phosphatase activity
CHF41_RS02395	COG0051	transcription antitermination factor activity, RNA binding
CHF41_RS02405	COG0088	Forms part of the polypeptide exit tunnel
CHF41_RS02410	COG0089	rRNA binding
CHF41_RS02415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHF41_RS02420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHF41_RS02425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CHF41_RS02430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHF41_RS02440	COG0255	Belongs to the universal ribosomal protein uL29 family
CHF41_RS02445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CHF41_RS02450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CHF41_RS02455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHF41_RS02460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHF41_RS02465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CHF41_RS02470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CHF41_RS02475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHF41_RS02480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHF41_RS02485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHF41_RS02490	COG1841	ribosomal large subunit assembly
CHF41_RS02495	COG0200	Binds to the 23S rRNA
CHF41_RS02500	COG0201	protein transport
CHF41_RS02505	COG0563	adenylate kinase activity
CHF41_RS02510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHF41_RS02515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHF41_RS02520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHF41_RS02530	COG0202	RNA polymerase activity
CHF41_RS02625	COG0582	viral genome integration into host DNA
CHF41_RS02650	COG3620	sequence-specific DNA binding
CHF41_RS02655	COG1846	Transcriptional regulator
CHF41_RS02660	COG1121	(ABC) transporter
CHF41_RS02665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHF41_RS02670	COG0803	Belongs to the bacterial solute-binding protein 9 family
CHF41_RS02670	COG3443	Belongs to the bacterial solute-binding protein 9 family
CHF41_RS02700	COG0085	RNA polymerase activity
CHF41_RS02705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CHF41_RS02715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHF41_RS02720	COG1459	type II secretion system
CHF41_RS02725	COG4537	Required for transformation and DNA binding
CHF41_RS02765	COG1363	Peptidase, m42
CHF41_RS02775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHF41_RS02780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHF41_RS02790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CHF41_RS02795	COG0459	protein refolding
CHF41_RS02815	COG0049	tRNA binding
CHF41_RS02820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHF41_RS02840	COG0126	phosphoglycerate kinase activity
CHF41_RS02850	COG0789	Transcriptional regulator
CHF41_RS02855	COG0174	glutamine synthetase
CHF41_RS02865	COG5503	Protein of unknown function (DUF1447)
CHF41_RS02870	COG1214	PFAM Peptidase M22, glycoprotease
CHF41_RS02880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHF41_RS02900	COG1131	(ABC) transporter
CHF41_RS02905	COG2081	HI0933 family
CHF41_RS02920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS02935	COG3959	Transketolase, thiamine diphosphate binding domain
CHF41_RS02940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CHF41_RS02950	COG1115	amino acid carrier protein
CHF41_RS02955	COG0668	transmembrane transport
CHF41_RS02970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CHF41_RS02975	COG0167	dihydroorotate dehydrogenase activity
CHF41_RS02985	COG0561	phosphatase activity
CHF41_RS02990	COG0561	phosphatase activity
CHF41_RS03005	COG1511	domain protein
CHF41_RS03010	COG1619	proteins homologs of microcin C7 resistance protein MccF
CHF41_RS03025	COG1696	Membrane protein involved in D-alanine export
CHF41_RS03035	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CHF41_RS03060	COG1694	Mazg nucleotide pyrophosphohydrolase
CHF41_RS03070	COG2094	Belongs to the DNA glycosylase MPG family
CHF41_RS03080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHF41_RS03085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CHF41_RS03095	COG0124	histidyl-tRNA synthetase
CHF41_RS03100	COG1454	alcohol dehydrogenase
CHF41_RS03100	COG1012	belongs to the aldehyde dehydrogenase family
CHF41_RS03105	COG3458	cephalosporin-C deacetylase activity
CHF41_RS03110	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CHF41_RS03120	COG1175	transmembrane transport
CHF41_RS03125	COG0395	ABC-type sugar transport system, permease component
CHF41_RS03140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHF41_RS03150	COG1737	Transcriptional regulator
CHF41_RS03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHF41_RS03165	COG0534	Mate efflux family protein
CHF41_RS03170	COG4978	Transcriptional regulator
CHF41_RS03170	COG0789	Transcriptional regulator
CHF41_RS03175	COG3804	dihydrodipicolinate reductase
CHF41_RS03180	COG3830	Belongs to the UPF0237 family
CHF41_RS03185	COG2848	UPF0210 protein
CHF41_RS03190	COG0588	phosphoglycerate mutase activity
CHF41_RS03220	COG1420	regulation of RNA biosynthetic process
CHF41_RS03225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CHF41_RS03230	COG0443	Heat shock 70 kDa protein
CHF41_RS03235	COG0484	heat shock protein binding
CHF41_RS03245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHF41_RS03250	COG0765	amino acid transport
CHF41_RS03265	COG0351	phosphomethylpyrimidine kinase
CHF41_RS03275	COG4475	Protein of unknown function (DUF436)
CHF41_RS03280	COG0544	peptidyl-prolyl cis-trans isomerase activity
CHF41_RS03285	COG3343	RNA polymerase activity
CHF41_RS03290	COG0504	CTP synthase activity
CHF41_RS03315	COG0191	fructose-bisphosphate aldolase activity
CHF41_RS03320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHF41_RS03335	COG1609	Transcriptional regulator
CHF41_RS03340	COG4209	transmembrane transport
CHF41_RS03345	COG0395	ABC-type sugar transport system, permease component
CHF41_RS03355	COG1621	beta-fructofuranosidase activity
CHF41_RS03365	COG0629	single-stranded DNA binding
CHF41_RS03370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CHF41_RS03390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHF41_RS03395	COG0006	proline dipeptidase activity
CHF41_RS03410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHF41_RS03415	COG1609	Transcriptional regulator
CHF41_RS03420	COG1621	beta-fructofuranosidase activity
CHF41_RS03425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS03425	COG2190	(PTS) system
CHF41_RS03425	COG1263	PTS System
CHF41_RS03430	COG1940	carbohydrate kinase activity
CHF41_RS03435	COG1482	cell wall glycoprotein biosynthetic process
CHF41_RS03440	COG0653	protein targeting
CHF41_RS03445	COG0736	holo-[acyl-carrier-protein] synthase activity
CHF41_RS03450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CHF41_RS03460	COG3684	Belongs to the aldolase LacD family
CHF41_RS03465	COG0527	aspartate kinase activity
CHF41_RS03470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHF41_RS03475	COG1024	Enoyl-CoA hydratase
CHF41_RS03485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHF41_RS03500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CHF41_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
CHF41_RS03510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHF41_RS03520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHF41_RS03525	COG0439	Biotin carboxylase
CHF41_RS03555	COG3716	PTS system mannose fructose sorbose family IID component
CHF41_RS03560	COG3715	PTS system
CHF41_RS03570	COG0561	phosphatase activity
CHF41_RS03575	COG2252	PERMEase
CHF41_RS03580	COG0802	atpase or kinase
CHF41_RS03585	COG0456	acetyltransferase
CHF41_RS03590	COG1316	TRANSCRIPTIONal
CHF41_RS03600	COG0537	adenosine 5'-monophosphoramidase activity
CHF41_RS03605	COG1131	(ABC) transporter
CHF41_RS03610	COG4473	ABC transporter
CHF41_RS03620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHF41_RS03625	COG0779	Required for maturation of 30S ribosomal subunits
CHF41_RS03630	COG0195	Participates in both transcription termination and antitermination
CHF41_RS03635	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CHF41_RS03645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CHF41_RS03650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHF41_RS03655	COG2151	metal-sulfur cluster biosynthetic enzyme
CHF41_RS03675	COG0028	Belongs to the TPP enzyme family
CHF41_RS03680	COG0440	acetolactate synthase activity
CHF41_RS03685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CHF41_RS03690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CHF41_RS03705	COG1126	abc transporter atp-binding protein
CHF41_RS03710	COG0765	amino acid transport
CHF41_RS03715	COG1968	undecaprenyl-diphosphatase activity
CHF41_RS03720	COG4862	establishment of competence for transformation
CHF41_RS03725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHF41_RS03735	COG0719	Fe-S assembly protein
CHF41_RS03740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHF41_RS03750	COG0719	Fe-S assembly protein
CHF41_RS03760	COG4166	transmembrane transport
CHF41_RS03765	COG4166	transmembrane transport
CHF41_RS03770	COG0601	transmembrane transport
CHF41_RS03775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHF41_RS03780	COG0444	Belongs to the ABC transporter superfamily
CHF41_RS03785	COG4608	Belongs to the ABC transporter superfamily
CHF41_RS03855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CHF41_RS03860	COG0252	asparaginase activity
CHF41_RS03865	COG0561	phosphatase activity
CHF41_RS03875	COG0589	response to stress
CHF41_RS03880	COG0436	Aminotransferase
CHF41_RS03885	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CHF41_RS03890	COG1335	isochorismatase
CHF41_RS03900	COG0154	amidase activity
CHF41_RS03905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHF41_RS03910	COG1609	Transcriptional regulator
CHF41_RS03915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CHF41_RS03920	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CHF41_RS03925	COG0697	spore germination
CHF41_RS03930	COG3142	Participates in the control of copper homeostasis
CHF41_RS03945	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CHF41_RS03950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CHF41_RS03955	COG1534	Rna-binding protein
CHF41_RS03960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CHF41_RS03965	COG1713	HD superfamily hydrolase involved in NAD metabolism
CHF41_RS03970	COG0799	negative regulation of ribosome biogenesis
CHF41_RS03975	COG2226	methyltransferase
CHF41_RS03985	COG0242	peptide deformylase activity
CHF41_RS04005	COG1640	4-alpha-glucanotransferase
CHF41_RS04010	COG0058	SHG alpha-glucan phosphorylase activity
CHF41_RS04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS04020	COG1263	PTS System
CHF41_RS04020	COG2190	(PTS) system
CHF41_RS04040	COG0217	transcriptional regulatory protein
CHF41_RS04070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CHF41_RS04080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHF41_RS04085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CHF41_RS04100	COG1464	Belongs to the NlpA lipoprotein family
CHF41_RS04105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHF41_RS04110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHF41_RS04120	COG0656	L-ascorbic acid biosynthetic process
CHF41_RS04125	COG0752	glycyl-tRNA synthetase alpha subunit
CHF41_RS04130	COG0751	glycine-tRNA ligase activity
CHF41_RS04135	COG4224	UPF0291 protein
CHF41_RS04140	COG0534	Mate efflux family protein
CHF41_RS04145	COG0569	domain protein
CHF41_RS04150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHF41_RS04160	COG1252	NADH dehydrogenase
CHF41_RS04165	COG0142	geranyltranstransferase activity
CHF41_RS04170	COG4939	FMN-binding domain protein
CHF41_RS04175	COG1477	protein flavinylation
CHF41_RS04210	COG0768	penicillin binding
CHF41_RS04215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHF41_RS04220	COG0513	Belongs to the DEAD box helicase family
CHF41_RS04230	COG0492	ferredoxin-NADP+ reductase activity
CHF41_RS04240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHF41_RS04245	COG0745	RESPONSE REGULATOR receiver
CHF41_RS04255	COG0628	permease
CHF41_RS04260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHF41_RS04270	COG1484	DNA-dependent DNA replication
CHF41_RS04280	COG1160	GTP binding
CHF41_RS04290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHF41_RS04300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHF41_RS04310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CHF41_RS04315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHF41_RS04325	COG0706	membrane insertase activity
CHF41_RS04330	COG1254	Belongs to the acylphosphatase family
CHF41_RS04335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHF41_RS04350	COG1125	glycine betaine transport
CHF41_RS04350	COG0517	IMP dehydrogenase activity
CHF41_RS04360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHF41_RS04370	COG0470	DNA polymerase III
CHF41_RS04375	COG4467	Involved in initiation control of chromosome replication
CHF41_RS04385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CHF41_RS04395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CHF41_RS04410	COG1393	Belongs to the ArsC family
CHF41_RS04420	COG0708	Exodeoxyribonuclease III
CHF41_RS04425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHF41_RS04425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHF41_RS04440	COG4122	O-methyltransferase activity
CHF41_RS04445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHF41_RS04465	COG1476	TRANSCRIPTIONal
CHF41_RS04490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHF41_RS04495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHF41_RS04500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHF41_RS04505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS04550	COG3763	UPF0154 protein
CHF41_RS04555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CHF41_RS04580	COG0582	viral genome integration into host DNA
CHF41_RS04585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CHF41_RS04590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CHF41_RS04595	COG1187	pseudouridine synthase activity
CHF41_RS04600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CHF41_RS04605	COG1027	Aspartate ammonia-lyase
CHF41_RS04610	COG0583	DNA-binding transcription factor activity
CHF41_RS04615	COG3711	transcriptional antiterminator
CHF41_RS04615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS04620	COG1447	Phosphotransferase system cellobiose-specific component IIA
CHF41_RS04630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHF41_RS04645	COG1363	Peptidase, m42
CHF41_RS04650	COG1446	asparaginase
CHF41_RS04665	COG4483	Protein conserved in bacteria
CHF41_RS04690	COG0742	ribosomal rna small subunit methyltransferase
CHF41_RS04695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CHF41_RS04705	COG4470	Protein conserved in bacteria
CHF41_RS04720	COG0133	tryptophan synthase activity
CHF41_RS04725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CHF41_RS04735	COG3579	cysteine-type endopeptidase activity
CHF41_RS04740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CHF41_RS04745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CHF41_RS04755	COG1242	4 iron, 4 sulfur cluster binding
CHF41_RS04760	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CHF41_RS04770	COG0025	NhaP-type Na H and K H
CHF41_RS04775	COG1119	ATPase activity
CHF41_RS04780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHF41_RS04785	COG1253	flavin adenine dinucleotide binding
CHF41_RS04790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CHF41_RS04800	COG1227	inorganic diphosphatase activity
CHF41_RS04825	COG2205	protein histidine kinase activity
CHF41_RS04830	COG1136	(ABC) transporter
CHF41_RS04835	COG0577	efflux transmembrane transporter activity
CHF41_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
CHF41_RS04850	COG2267	carboxylic ester hydrolase activity
CHF41_RS04865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CHF41_RS04870	COG0494	nUDIX hydrolase
CHF41_RS04880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CHF41_RS04885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHF41_RS04910	COG0697	spore germination
CHF41_RS04910	COG1674	ftsk spoiiie
CHF41_RS04915	COG0346	lactoylglutathione lyase activity
CHF41_RS04930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHF41_RS04940	COG0625	glutathione transferase activity
CHF41_RS04945	COG2244	polysaccharide biosynthetic process
CHF41_RS04950	COG0528	UMP kinase activity
CHF41_RS04955	COG0233	cytoplasmic translational termination
CHF41_RS04960	COG2996	Protein conserved in bacteria
CHF41_RS04970	COG4479	Belongs to the UPF0346 family
CHF41_RS04975	COG1702	phosphate starvation-inducible protein PhoH
CHF41_RS04985	COG0686	Belongs to the AlaDH PNT family
CHF41_RS05030	COG1705	Flagellar rod assembly protein muramidase FlgJ
CHF41_RS05030	COG3942	CHAP domain
CHF41_RS05060	COG1596	polysaccharide export
CHF41_RS05060	COG1555	photosystem II stabilization
CHF41_RS05065	COG2333	competence protein COMEC
CHF41_RS05065	COG0658	competence protein
CHF41_RS05070	COG0318	PFAM AMP-dependent synthetase and ligase
CHF41_RS05080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CHF41_RS05090	COG0436	Aminotransferase
CHF41_RS05095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CHF41_RS05100	COG0363	glucosamine-6-phosphate deaminase activity
CHF41_RS05105	COG1187	pseudouridine synthase activity
CHF41_RS05115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CHF41_RS05120	COG0626	cystathionine gamma-synthase activity
CHF41_RS05125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CHF41_RS05145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CHF41_RS05155	COG0583	DNA-binding transcription factor activity
CHF41_RS05160	COG0110	maltose O-acetyltransferase activity
CHF41_RS05175	COG0683	leucine binding
CHF41_RS05180	COG0559	Belongs to the binding-protein-dependent transport system permease family
CHF41_RS05200	COG0571	ribonuclease III activity
CHF41_RS05205	COG1196	nuclear chromosome segregation
CHF41_RS05215	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHF41_RS05225	COG0561	phosphatase activity
CHF41_RS05230	COG0561	phosphatase activity
CHF41_RS05235	COG0552	protein localization to endoplasmic reticulum
CHF41_RS05245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CHF41_RS05255	COG3689	TIGRFAM TIGR03943 family protein
CHF41_RS05260	COG0701	Predicted permease
CHF41_RS05270	COG1597	lipid kinase activity
CHF41_RS05280	COG0356	it plays a direct role in the translocation of protons across the membrane
CHF41_RS05285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CHF41_RS05290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHF41_RS05295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CHF41_RS05300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CHF41_RS05305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CHF41_RS05310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CHF41_RS05320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CHF41_RS05350	COG0072	phenylalanine-tRNA ligase activity
CHF41_RS05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHF41_RS05365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CHF41_RS05365	COG3064	Membrane
CHF41_RS05365	COG3583	domain protein
CHF41_RS05380	COG1136	(ABC) transporter
CHF41_RS05385	COG0745	RESPONSE REGULATOR receiver
CHF41_RS05390	COG5002	protein histidine kinase activity
CHF41_RS05400	COG2807	transmembrane transport
CHF41_RS05410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CHF41_RS05415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHF41_RS05425	COG1234	tRNA 3'-trailer cleavage
CHF41_RS05430	COG0300	oxidoreductase activity
CHF41_RS05435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHF41_RS05450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CHF41_RS05450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHF41_RS05460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHF41_RS05475	COG2384	SAM-dependent methyltransferase
CHF41_RS05480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CHF41_RS05485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CHF41_RS05495	COG1088	dTDP-glucose 4,6-dehydratase activity
CHF41_RS05505	COG1216	Glycosyl transferase, family 2
CHF41_RS05525	COG1091	dTDP-4-dehydrorhamnose reductase activity
CHF41_RS05535	COG1216	Glycosyl transferase, family 2
CHF41_RS05535	COG1442	glycosyl transferase family 8
CHF41_RS05550	COG3475	LICD family
CHF41_RS05560	COG0463	Glycosyl transferase, family 2
CHF41_RS05585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CHF41_RS05595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHF41_RS05610	COG1368	sulfuric ester hydrolase activity
CHF41_RS05615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CHF41_RS05620	COG0710	3-dehydroquinate dehydratase activity
CHF41_RS05625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CHF41_RS05630	COG0287	Prephenate dehydrogenase
CHF41_RS05635	COG3679	Belongs to the UPF0342 family
CHF41_RS05655	COG4120	Belongs to the binding-protein-dependent transport system permease family
CHF41_RS05660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHF41_RS05665	COG0583	DNA-binding transcription factor activity
CHF41_RS05680	COG2271	Major facilitator Superfamily
CHF41_RS05685	COG2271	Major facilitator Superfamily
CHF41_RS05690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CHF41_RS05700	COG2851	Citrate transporter
CHF41_RS05705	COG0710	3-dehydroquinate dehydratase activity
CHF41_RS05710	COG1902	pentaerythritol trinitrate reductase activity
CHF41_RS05725	COG0077	Prephenate dehydratase
CHF41_RS05735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHF41_RS05810	COG0551	DNA topoisomerase type I activity
CHF41_RS05810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHF41_RS05840	COG5290	Psort location Cytoplasmic, score
CHF41_RS05855	COG1309	transcriptional regulator
CHF41_RS05860	COG1132	(ABC) transporter
CHF41_RS05865	COG1132	(ABC) transporter
CHF41_RS05870	COG1129	ABC transporter
CHF41_RS05900	COG1846	Transcriptional regulator
CHF41_RS05925	COG2315	Protein conserved in bacteria
CHF41_RS05945	COG3209	COG3209 Rhs family protein
CHF41_RS05990	COG3541	Predicted nucleotidyltransferase
CHF41_RS06015	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHF41_RS06035	COG2706	6-phosphogluconolactonase activity
CHF41_RS06040	COG0628	permease
CHF41_RS06050	COG3527	Alpha-acetolactate decarboxylase
CHF41_RS06060	COG1051	belongs to the nudix hydrolase family
CHF41_RS06065	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CHF41_RS06110	COG0488	(ABC) transporter
CHF41_RS06115	COG1879	ABC-type sugar transport system periplasmic component
CHF41_RS06125	COG4211	Belongs to the binding-protein-dependent transport system permease family
CHF41_RS06130	COG5416	Lipopolysaccharide assembly protein A domain
CHF41_RS06135	COG3442	glutamine amidotransferase
CHF41_RS06140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHF41_RS06145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CHF41_RS06155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHF41_RS06160	COG0488	(ABC) transporter
CHF41_RS06170	COG1573	uracil-dna glycosylase
CHF41_RS06180	COG1704	LemA family
CHF41_RS06185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CHF41_RS06190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CHF41_RS06205	COG0813	purine-nucleoside phosphorylase activity
CHF41_RS06210	COG0058	SHG alpha-glucan phosphorylase activity
CHF41_RS06225	COG0210	DNA helicase
CHF41_RS06235	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CHF41_RS06240	COG1074	ATP-dependent DNA helicase activity
CHF41_RS06255	COG1609	Transcriptional regulator
CHF41_RS06260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS06260	COG1263	PTS System
CHF41_RS06285	COG1011	Hydrolase
CHF41_RS06325	COG0488	(ABC) transporter
CHF41_RS06335	COG0481	GTPase activity
CHF41_RS06345	COG1126	abc transporter atp-binding protein
CHF41_RS06350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHF41_RS06360	COG0556	nucleotide-excision repair
CHF41_RS06365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHF41_RS06375	COG1051	belongs to the nudix hydrolase family
CHF41_RS06380	COG0647	UMP catabolic process
CHF41_RS06390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CHF41_RS06395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CHF41_RS06405	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CHF41_RS06420	COG1122	ATPase activity
CHF41_RS06425	COG1122	ATPase activity
CHF41_RS06430	COG1970	mechanosensitive ion channel activity
CHF41_RS06435	COG0358	DNA primase activity
CHF41_RS06440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHF41_RS06445	COG2151	metal-sulfur cluster biosynthetic enzyme
CHF41_RS06465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CHF41_RS06475	COG1131	(ABC) transporter
CHF41_RS06490	COG0205	6-phosphofructokinase activity
CHF41_RS06495	COG0469	pyruvate kinase activity
CHF41_RS06500	COG1349	DNA-binding transcription factor activity
CHF41_RS06505	COG0698	ribose 5-phosphate isomerase
CHF41_RS06510	COG0149	triose-phosphate isomerase activity
CHF41_RS06515	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CHF41_RS06520	COG2376	Dihydroxyacetone kinase
CHF41_RS06525	COG1461	Dihydroxyacetone kinase
CHF41_RS06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CHF41_RS06555	COG0657	acetylesterase activity
CHF41_RS06555	COG2755	lipolytic protein G-D-S-L family
CHF41_RS06565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHF41_RS06570	COG0765	amino acid transport
CHF41_RS06575	COG1126	abc transporter atp-binding protein
CHF41_RS06580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHF41_RS06585	COG2213	PTS system mannitol-specific
CHF41_RS06590	COG3711	transcriptional antiterminator
CHF41_RS06595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS06600	COG0246	Mannitol dehydrogenase
CHF41_RS06605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CHF41_RS06630	COG1396	sequence-specific DNA binding
CHF41_RS06635	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHF41_RS06640	COG0561	phosphatase activity
CHF41_RS06715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CHF41_RS06720	COG4988	ABC transporter
CHF41_RS06725	COG1294	oxidase, subunit
CHF41_RS06730	COG1271	oxidase subunit
CHF41_RS06735	COG1252	NADH dehydrogenase
CHF41_RS06755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHF41_RS06760	COG0196	riboflavin kinase activity
CHF41_RS06765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CHF41_RS06770	COG1393	Belongs to the ArsC family
CHF41_RS06780	COG0483	inositol monophosphate 1-phosphatase activity
CHF41_RS06785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHF41_RS06785	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CHF41_RS06795	COG0573	inorganic phosphate transmembrane transporter activity
CHF41_RS06800	COG0581	inorganic phosphate transmembrane transporter activity
CHF41_RS06805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHF41_RS06810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHF41_RS06815	COG0704	Plays a role in the regulation of phosphate uptake
CHF41_RS06820	COG0745	RESPONSE REGULATOR receiver
CHF41_RS06825	COG5002	protein histidine kinase activity
CHF41_RS06830	COG3976	FMN-binding domain protein
CHF41_RS06830	COG1053	succinate dehydrogenase
CHF41_RS06845	COG1072	(Pantothenic acid kinase))
CHF41_RS06850	COG2813	Specifically methylates the guanine in position
CHF41_RS06870	COG1744	ABC transporter substrate-binding protein PnrA-like
CHF41_RS06875	COG3845	ABC transporter
CHF41_RS06880	COG4603	Belongs to the binding-protein-dependent transport system permease family
CHF41_RS06885	COG1079	Belongs to the binding-protein-dependent transport system permease family
CHF41_RS06895	COG0039	L-malate dehydrogenase activity
CHF41_RS06900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHF41_RS06905	COG3764	Sortase (surface protein transpeptidase)
CHF41_RS06920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CHF41_RS06940	COG1104	cysteine desulfurase activity
CHF41_RS06955	COG2357	RelA SpoT domain protein
CHF41_RS06960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CHF41_RS06965	COG0564	pseudouridine synthase activity
CHF41_RS06970	COG0280	phosphate acetyltransferase
CHF41_RS06980	COG1132	(ABC) transporter
CHF41_RS06985	COG1194	a g-specific adenine glycosylase
CHF41_RS06990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHF41_RS06995	COG4684	Psort location CytoplasmicMembrane, score
CHF41_RS07000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHF41_RS07010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CHF41_RS07035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHF41_RS07045	COG0789	Transcriptional regulator
CHF41_RS07055	COG1132	(ABC) transporter
CHF41_RS07060	COG1132	(ABC) transporter
CHF41_RS07065	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHF41_RS07075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CHF41_RS07080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CHF41_RS07085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHF41_RS07090	COG1164	Oligoendopeptidase f
CHF41_RS07110	COG1063	alcohol dehydrogenase
CHF41_RS07115	COG0596	Alpha beta hydrolase
CHF41_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
CHF41_RS07125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CHF41_RS07130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHF41_RS07135	COG0110	maltose O-acetyltransferase activity
CHF41_RS07140	COG0758	DNA mediated transformation
CHF41_RS07145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHF41_RS07150	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CHF41_RS07155	COG0789	Transcriptional regulator
CHF41_RS07175	COG3711	transcriptional antiterminator
CHF41_RS07180	COG1263	PTS System
CHF41_RS07180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS07180	COG2190	(PTS) system
CHF41_RS07205	COG1136	(ABC) transporter
CHF41_RS07215	COG0745	RESPONSE REGULATOR receiver
CHF41_RS07220	COG5002	protein histidine kinase activity
CHF41_RS07230	COG4974	Belongs to the 'phage' integrase family
CHF41_RS07245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHF41_RS07255	COG2188	Transcriptional regulator
CHF41_RS07295	COG4221	oxidoreductase activity
CHF41_RS07310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CHF41_RS07320	COG2890	protein-(glutamine-N5) methyltransferase activity
CHF41_RS07325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CHF41_RS07330	COG1435	thymidine kinase activity
CHF41_RS07335	COG1942	4-Oxalocrotonate Tautomerase
CHF41_RS07350	COG0534	Mate efflux family protein
CHF41_RS07355	COG5002	protein histidine kinase activity
CHF41_RS07385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CHF41_RS07390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CHF41_RS07395	COG1177	transmembrane transport
CHF41_RS07400	COG1176	ABC-type spermidine putrescine transport system, permease component I
CHF41_RS07410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHF41_RS07415	COG0083	homoserine kinase activity
CHF41_RS07420	COG0460	homoserine dehydrogenase
CHF41_RS07425	COG0726	polysaccharide deacetylase
CHF41_RS07430	COG2723	6-phospho-beta-galactosidase activity
CHF41_RS07435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHF41_RS07435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHF41_RS07440	COG1447	Phosphotransferase system cellobiose-specific component IIA
CHF41_RS07445	COG3711	transcriptional antiterminator
CHF41_RS07455	COG0698	ribose 5-phosphate isomerase
CHF41_RS07460	COG0698	ribose 5-phosphate isomerase
CHF41_RS07465	COG1349	DNA-binding transcription factor activity
CHF41_RS07470	COG0561	phosphatase activity
CHF41_RS07485	COG0222	ribosome binding
CHF41_RS07500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CHF41_RS07505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHF41_RS07515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHF41_RS07520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CHF41_RS07530	COG0395	ABC-type sugar transport system, permease component
CHF41_RS07545	COG2207	Transcriptional regulator
CHF41_RS07555	COG1940	carbohydrate kinase activity
CHF41_RS07565	COG0488	(ABC) transporter
CHF41_RS07570	COG0617	tRNA 3'-terminal CCA addition
CHF41_RS07575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHF41_RS07580	COG1307	EDD domain protein, DegV family
CHF41_RS07590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHF41_RS07590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS07590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHF41_RS07595	COG1105	Belongs to the carbohydrate kinase PfkB family
CHF41_RS07600	COG1349	DNA-binding transcription factor activity
CHF41_RS07615	COG3443	Belongs to the bacterial solute-binding protein 9 family
CHF41_RS07615	COG0803	Belongs to the bacterial solute-binding protein 9 family
CHF41_RS07620	COG0336	Belongs to the RNA methyltransferase TrmD family
CHF41_RS07625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CHF41_RS07655	COG0505	Belongs to the CarA family
CHF41_RS07660	COG0540	Belongs to the ATCase OTCase family
CHF41_RS07665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CHF41_RS07680	COG2824	Alkylphosphonate utilization operon protein PhnA
CHF41_RS07685	COG0564	pseudouridine synthase activity
CHF41_RS07695	COG0583	DNA-binding transcription factor activity
CHF41_RS07710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CHF41_RS07715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CHF41_RS07730	COG0301	tRNA thio-modification
CHF41_RS07735	COG1104	cysteine desulfurase activity
CHF41_RS07750	COG0539	negative regulation of cytoplasmic translation
CHF41_RS07770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHF41_RS07775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHF41_RS07785	COG0187	DNA topoisomerase II activity
CHF41_RS07790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CHF41_RS07795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CHF41_RS07800	COG1051	belongs to the nudix hydrolase family
CHF41_RS07805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHF41_RS07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHF41_RS07835	COG0167	dihydroorotate dehydrogenase activity
CHF41_RS07845	COG0583	DNA-binding transcription factor activity
CHF41_RS07855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CHF41_RS07860	COG0297	glycogen (starch) synthase activity
CHF41_RS07870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHF41_RS07890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHF41_RS07895	COG0438	transferase activity, transferring glycosyl groups
CHF41_RS07900	COG0438	transferase activity, transferring glycosyl groups
CHF41_RS07910	COG0438	transferase activity, transferring glycosyl groups
CHF41_RS07925	COG4464	protein tyrosine phosphatase activity
CHF41_RS07935	COG1396	sequence-specific DNA binding
CHF41_RS07970	COG3475	LICD family
CHF41_RS07975	COG1216	Glycosyl transferase, family 2
CHF41_RS07980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CHF41_RS07985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHF41_RS08040	COG2972	Histidine kinase
CHF41_RS08050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHF41_RS08050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHF41_RS08055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHF41_RS08065	COG0785	Cytochrome C biogenesis protein
CHF41_RS08070	COG1114	Component of the transport system for branched-chain amino acids
CHF41_RS08075	COG2217	Heavy metal translocating P-type atpase
CHF41_RS08090	COG2855	membrane
CHF41_RS08100	COG0560	Phosphoserine phosphatase
CHF41_RS08105	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CHF41_RS08110	COG0187	DNA topoisomerase II activity
CHF41_RS08115	COG0693	protein deglycase activity
CHF41_RS08120	COG0772	Belongs to the SEDS family
CHF41_RS08145	COG0254	rRNA binding
CHF41_RS08150	COG3976	FMN-binding domain protein
CHF41_RS08150	COG1053	succinate dehydrogenase
CHF41_RS08150	COG0431	NADPH-dependent FMN reductase
CHF41_RS08165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CHF41_RS08170	COG0716	FMN binding
CHF41_RS08175	COG0038	chloride channel
CHF41_RS08190	COG0335	large ribosomal subunit rRNA binding
CHF41_RS08195	COG1481	regulation of sporulation
CHF41_RS08200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CHF41_RS08205	COG1660	Displays ATPase and GTPase activities
CHF41_RS08210	COG0251	oxidation-reduction process
CHF41_RS08215	COG1764	response to oxidative stress
CHF41_RS08220	COG0017	Asparaginyl-tRNA synthetase
CHF41_RS08225	COG0436	Aminotransferase
CHF41_RS08230	COG5353	protein conserved in bacteria
CHF41_RS08240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CHF41_RS08255	COG1272	protein, Hemolysin III
CHF41_RS08260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CHF41_RS08285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHF41_RS08290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CHF41_RS08295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CHF41_RS08300	COG1199	ATP-dependent helicase activity
CHF41_RS08300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHF41_RS08310	COG2177	Part of the ABC transporter FtsEX involved in
CHF41_RS08315	COG2884	Cell division ATP-binding protein ftsE
CHF41_RS08325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CHF41_RS08365	COG1078	dGTPase activity
CHF41_RS08400	COG0149	triose-phosphate isomerase activity
CHF41_RS08405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHF41_RS08430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CHF41_RS08435	COG0772	Belongs to the SEDS family
CHF41_RS08465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CHF41_RS08470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CHF41_RS08485	COG0577	efflux transmembrane transporter activity
CHF41_RS08490	COG1136	(ABC) transporter
CHF41_RS08500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHF41_RS08505	COG1268	BioY protein
CHF41_RS08510	COG4443	Transcriptional Coactivator p15 (PC4)
CHF41_RS08520	COG0826	peptidase U32
CHF41_RS08545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CHF41_RS08550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CHF41_RS08565	COG3091	SprT-like family
CHF41_RS08570	COG2183	response to ionizing radiation
CHF41_RS08575	COG4708	membrane
CHF41_RS08590	COG0024	Methionine aminopeptidase
CHF41_RS08610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHF41_RS08620	COG4152	abc transporter atp-binding protein
CHF41_RS08625	COG2131	deaminase
CHF41_RS08630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHF41_RS08630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHF41_RS08655	COG2217	Heavy metal translocating P-type atpase
CHF41_RS08665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CHF41_RS08670	COG0557	exoribonuclease II activity
CHF41_RS08680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHF41_RS08685	COG2814	Major facilitator Superfamily
CHF41_RS08690	COG0237	dephospho-CoA kinase activity
CHF41_RS08695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CHF41_RS08730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHF41_RS08740	COG1447	Phosphotransferase system cellobiose-specific component IIA
CHF41_RS08750	COG3711	transcriptional antiterminator
CHF41_RS08750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS08760	COG2723	6-phospho-beta-galactosidase activity
CHF41_RS08765	COG1132	(ABC) transporter
CHF41_RS08770	COG1132	(ABC) transporter
CHF41_RS08780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHF41_RS08785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHF41_RS08790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHF41_RS08790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHF41_RS08790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHF41_RS08795	COG3711	transcriptional antiterminator
CHF41_RS08800	COG0204	Acyl-transferase
CHF41_RS08805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CHF41_RS08820	COG1755	Isoprenylcysteine carboxyl methyltransferase
CHF41_RS08830	COG0640	Transcriptional regulator
CHF41_RS08835	COG0513	Belongs to the DEAD box helicase family
CHF41_RS08855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CHF41_RS08865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHF41_RS08870	COG1136	(ABC) transporter
CHF41_RS08885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CHF41_RS08890	COG0768	penicillin binding
CHF41_RS08895	COG0488	(ABC) transporter
CHF41_RS08900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHF41_RS08910	COG0745	RESPONSE REGULATOR receiver
CHF41_RS08925	COG1064	alcohol dehydrogenase
CHF41_RS08960	COG0438	transferase activity, transferring glycosyl groups
CHF41_RS08970	COG1609	Transcriptional regulator
CHF41_RS08975	COG0006	proline dipeptidase activity
CHF41_RS08985	COG0596	Alpha beta hydrolase
CHF41_RS08990	COG0604	alcohol dehydrogenase
CHF41_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
CHF41_RS08990	COG3321	synthase
CHF41_RS09000	COG2514	catechol 2,3-dioxygenase activity
CHF41_RS09005	COG2910	NAD(P)H-binding
CHF41_RS09015	COG1959	2 iron, 2 sulfur cluster binding
CHF41_RS09020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CHF41_RS09025	COG0372	Belongs to the citrate synthase family
CHF41_RS09030	COG0538	isocitrate dehydrogenase activity
CHF41_RS09035	COG0789	Transcriptional regulator
CHF41_RS09040	COG0343	queuine tRNA-ribosyltransferase activity
CHF41_RS09050	COG1363	Peptidase, m42
CHF41_RS09065	COG1285	pathogenesis
CHF41_RS09070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHF41_RS09080	COG0066	3-isopropylmalate dehydratase activity
CHF41_RS09115	COG0673	inositol 2-dehydrogenase activity
CHF41_RS09140	COG4372	Transposase
CHF41_RS09220	COG0726	polysaccharide deacetylase
CHF41_RS09235	COG0183	Belongs to the thiolase family
CHF41_RS09240	COG3425	synthase
CHF41_RS09260	COG0776	regulation of translation
CHF41_RS09270	COG2755	lipolytic protein G-D-S-L family
CHF41_RS09275	COG1307	EDD domain protein, DegV family
CHF41_RS09280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CHF41_RS09285	COG0497	DNA recombination
CHF41_RS09290	COG1438	arginine binding
CHF41_RS09295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CHF41_RS09305	COG1722	exodeoxyribonuclease VII activity
CHF41_RS09310	COG1570	exodeoxyribonuclease VII activity
CHF41_RS09315	COG2197	response regulator
CHF41_RS09320	COG4585	Histidine kinase
CHF41_RS09325	COG0842	Transport permease protein
CHF41_RS09330	COG1131	(ABC) transporter
CHF41_RS09345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CHF41_RS09360	COG0671	phosphoesterase, PA-phosphatase related
CHF41_RS09365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CHF41_RS09390	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CHF41_RS09395	COG1518	maintenance of DNA repeat elements
CHF41_RS09400	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CHF41_RS09405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CHF41_RS09410	COG1126	abc transporter atp-binding protein
CHF41_RS09415	COG0765	amino acid transport
CHF41_RS09420	COG4703	Protein of unknown function (DUF1797)
CHF41_RS09425	COG0542	response to heat
CHF41_RS09430	COG0494	nUDIX hydrolase
CHF41_RS09445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CHF41_RS09455	COG3599	regulation of cell shape
CHF41_RS09460	COG2302	S4 RNA-binding domain
CHF41_RS09465	COG0762	integral membrane protein
CHF41_RS09470	COG1799	cell septum assembly
CHF41_RS09475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CHF41_RS09495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHF41_RS09510	COG1217	gtp-binding protein TYPA
CHF41_RS09530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CHF41_RS09535	COG0805	protein transport
CHF41_RS09540	COG0672	)-iron permease
CHF41_RS09545	COG2837	iron assimilation
CHF41_RS09550	COG2822	iron ion transport
CHF41_RS09565	COG1832	CoA-binding protein
CHF41_RS09570	COG1132	(ABC) transporter
CHF41_RS09585	COG1132	(ABC) transporter
CHF41_RS09595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CHF41_RS09600	COG3314	Sporulation integral membrane protein YlbJ
CHF41_RS09625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHF41_RS09645	COG0346	lactoylglutathione lyase activity
CHF41_RS09650	COG0519	Catalyzes the synthesis of GMP from XMP
CHF41_RS09660	COG4175	Glycine betaine
CHF41_RS09660	COG3448	diguanylate cyclase activity
CHF41_RS09690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CHF41_RS09700	COG0095	Lipoate-protein ligase
CHF41_RS09730	COG1113	amino acid transport
CHF41_RS09735	COG2017	converts alpha-aldose to the beta-anomer
CHF41_RS09745	COG3716	PTS system mannose fructose sorbose family IID component
CHF41_RS09750	COG3715	PTS system
CHF41_RS09755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHF41_RS09770	COG2188	Transcriptional regulator
CHF41_RS09780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHF41_RS09785	COG2137	regulation of response to DNA damage stimulus
CHF41_RS09790	COG3557	Belongs to the UPF0374 family
CHF41_RS09865	COG0582	viral genome integration into host DNA
CHF41_RS09990	COG0582	viral genome integration into host DNA