locus-tag	class	description
LPB404_RS00050	COG0756	dUTP diphosphatase activity
LPB404_RS00055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPB404_RS00060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPB404_RS00065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPB404_RS00080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPB404_RS00130	COG3732	PTS system glucitol sorbitol-specific
LPB404_RS00135	COG3730	PTS system glucitol sorbitol-specific
LPB404_RS00155	COG0166	Belongs to the GPI family
LPB404_RS00170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPB404_RS00175	COG2918	glutathione biosynthetic process
LPB404_RS00175	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPB404_RS00185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPB404_RS00190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPB404_RS00200	COG3201	nicotinamide mononucleotide transporter
LPB404_RS00205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPB404_RS00230	COG4463	regulation of RNA biosynthetic process
LPB404_RS00250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPB404_RS00280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPB404_RS00285	COG2321	neutral zinc metallopeptidase
LPB404_RS00290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPB404_RS00295	COG0564	pseudouridine synthase activity
LPB404_RS00305	COG0803	Belongs to the bacterial solute-binding protein 9 family
LPB404_RS00325	COG0438	transferase activity, transferring glycosyl groups
LPB404_RS00330	COG0562	UDP-galactopyranose mutase
LPB404_RS00345	COG1063	alcohol dehydrogenase
LPB404_RS00350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LPB404_RS00355	COG1215	transferase activity, transferring glycosyl groups
LPB404_RS00360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPB404_RS00365	COG0438	transferase activity, transferring glycosyl groups
LPB404_RS00370	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LPB404_RS00375	COG3475	LICD family
LPB404_RS00385	COG0489	protein tyrosine kinase activity
LPB404_RS00390	COG3944	biosynthesis protein
LPB404_RS00395	COG4464	protein tyrosine phosphatase activity
LPB404_RS00400	COG1316	TRANSCRIPTIONal
LPB404_RS00410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPB404_RS00420	COG0285	dihydrofolate synthase activity
LPB404_RS00425	COG3906	Belongs to the UPF0473 family
LPB404_RS00435	COG4472	Bacterial protein of unknown function (DUF965)
LPB404_RS00450	COG1393	Belongs to the ArsC family
LPB404_RS00460	COG1058	Belongs to the CinA family
LPB404_RS00460	COG1546	Belongs to the CinA family
LPB404_RS00470	COG0519	Catalyzes the synthesis of GMP from XMP
LPB404_RS00480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPB404_RS00495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPB404_RS00500	COG1438	arginine binding
LPB404_RS00505	COG0018	arginyl-trna synthetase
LPB404_RS00515	COG1780	Probably involved in ribonucleotide reductase function
LPB404_RS00525	COG0058	SHG alpha-glucan phosphorylase activity
LPB404_RS00530	COG1640	4-alpha-glucanotransferase
LPB404_RS00535	COG2182	Extracellular solute-binding protein
LPB404_RS00540	COG1175	transmembrane transport
LPB404_RS00545	COG3833	ABC-type maltose transport systems, permease component
LPB404_RS00550	COG5521	maltodextrose utilization protein MalA
LPB404_RS00555	COG1609	Transcriptional regulator
LPB404_RS00560	COG1523	belongs to the glycosyl hydrolase 13 family
LPB404_RS00565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LPB404_RS00580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LPB404_RS00585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPB404_RS00590	COG1696	Membrane protein involved in D-alanine export
LPB404_RS00615	COG1511	domain protein
LPB404_RS00625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB404_RS00630	COG2274	protein secretion by the type I secretion system
LPB404_RS00635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LPB404_RS00645	COG0305	Participates in initiation and elongation during chromosome replication
LPB404_RS00650	COG0359	binds to the 23S rRNA
LPB404_RS00660	COG0445	tRNA wobble uridine modification
LPB404_RS00680	COG1760	l-serine dehydratase
LPB404_RS00685	COG1760	l-serine dehydratase
LPB404_RS00690	COG0546	phosphoglycolate phosphatase activity
LPB404_RS00695	COG0741	lytic transglycosylase activity
LPB404_RS00700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LPB404_RS00705	COG1122	ATPase activity
LPB404_RS00710	COG1122	ATPase activity
LPB404_RS00715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPB404_RS00720	COG0612	Peptidase, M16
LPB404_RS00730	COG2501	S4 domain
LPB404_RS00735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPB404_RS00740	COG0517	IMP dehydrogenase activity
LPB404_RS00740	COG0516	GMP reductase activity
LPB404_RS00745	COG0180	Tryptophanyl-tRNA synthetase
LPB404_RS00750	COG0488	(ABC) transporter
LPB404_RS00790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPB404_RS00795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPB404_RS00800	COG1475	DNA binding
LPB404_RS00810	COG0592	DNA-directed DNA polymerase activity
LPB404_RS00825	COG0012	GTP binding
LPB404_RS00830	COG0193	aminoacyl-tRNA hydrolase activity
LPB404_RS00835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPB404_RS00840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LPB404_RS00855	COG0037	tRNA processing
LPB404_RS00860	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPB404_RS00865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB404_RS00990	COG3942	CHAP domain
LPB404_RS00995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPB404_RS01010	COG0436	Aminotransferase
LPB404_RS01015	COG1381	Involved in DNA repair and RecF pathway recombination
LPB404_RS01025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPB404_RS01035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPB404_RS01050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPB404_RS01065	COG0138	bifunctional purine biosynthesis protein purh
LPB404_RS01070	COG3942	CHAP domain
LPB404_RS01075	COG0151	Belongs to the GarS family
LPB404_RS01080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LPB404_RS01120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LPB404_RS01125	COG2188	Transcriptional regulator
LPB404_RS01135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPB404_RS01140	COG3715	PTS system
LPB404_RS01145	COG3716	PTS system mannose fructose sorbose family IID component
LPB404_RS01155	COG2222	sugar isomerase
LPB404_RS01165	COG2255	four-way junction helicase activity
LPB404_RS01175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPB404_RS01185	COG2755	lipolytic protein G-D-S-L family
LPB404_RS01185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPB404_RS01190	COG1454	alcohol dehydrogenase
LPB404_RS01190	COG1012	belongs to the aldehyde dehydrogenase family
LPB404_RS01195	COG1063	alcohol dehydrogenase
LPB404_RS01230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LPB404_RS01240	COG1175	transmembrane transport
LPB404_RS01245	COG0395	ABC-type sugar transport system, permease component
LPB404_RS01250	COG2731	YhcH YjgK YiaL family protein
LPB404_RS01260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPB404_RS01280	COG1269	ATP hydrolysis coupled proton transport
LPB404_RS01285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB404_RS01295	COG1527	subunit (C
LPB404_RS01310	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LPB404_RS01315	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
LPB404_RS01320	COG1394	ATPase activity, coupled to movement of substances
LPB404_RS01330	COG2807	transmembrane transport
LPB404_RS01335	COG2151	metal-sulfur cluster biosynthetic enzyme
LPB404_RS01360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPB404_RS01365	COG4916	TIR domain
LPB404_RS01415	COG4974	Belongs to the 'phage' integrase family
LPB404_RS01445	COG0640	Transcriptional regulator
LPB404_RS01450	COG4932	domain protein
LPB404_RS01450	COG1388	LysM domain
LPB404_RS01475	COG1328	CTP reductase activity
LPB404_RS01505	COG0602	queuosine metabolic process
LPB404_RS01515	COG0534	Mate efflux family protein
LPB404_RS01520	COG0546	phosphoglycolate phosphatase activity
LPB404_RS01540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB404_RS01540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB404_RS01545	COG1832	CoA-binding protein
LPB404_RS01570	COG0088	Forms part of the polypeptide exit tunnel
LPB404_RS01585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPB404_RS01595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPB404_RS01605	COG0255	Belongs to the universal ribosomal protein uL29 family
LPB404_RS01610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPB404_RS01615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LPB404_RS01620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPB404_RS01625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LPB404_RS01630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LPB404_RS01650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LPB404_RS01655	COG1841	ribosomal large subunit assembly
LPB404_RS01665	COG0201	protein transport
LPB404_RS01675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPB404_RS01680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LPB404_RS01685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPB404_RS01690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPB404_RS01695	COG0202	RNA polymerase activity
LPB404_RS01790	COG1846	Transcriptional regulator
LPB404_RS01795	COG1121	(ABC) transporter
LPB404_RS01800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LPB404_RS01805	COG0803	Belongs to the bacterial solute-binding protein 9 family
LPB404_RS01805	COG3443	Belongs to the bacterial solute-binding protein 9 family
LPB404_RS01825	COG0383	alpha-mannosidase activity
LPB404_RS01840	COG4209	transmembrane transport
LPB404_RS01845	COG0395	ABC-type sugar transport system, permease component
LPB404_RS01850	COG1653	transport
LPB404_RS01860	COG2972	Histidine kinase
LPB404_RS01865	COG4753	response regulator
LPB404_RS01865	COG2207	Transcriptional regulator
LPB404_RS01870	COG2226	methyltransferase
LPB404_RS01880	COG4499	WXG100 protein secretion system (Wss), protein YukC
LPB404_RS01880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPB404_RS01885	COG0085	RNA polymerase activity
LPB404_RS01890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPB404_RS01900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPB404_RS01905	COG1459	type II secretion system
LPB404_RS01910	COG4537	Required for transformation and DNA binding
LPB404_RS01935	COG0827	DNA restriction-modification system
LPB404_RS01940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LPB404_RS01945	COG1266	CAAX protease self-immunity
LPB404_RS01950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPB404_RS01955	COG0285	dihydrofolate synthase activity
LPB404_RS01960	COG0302	gtp cyclohydrolase
LPB404_RS01965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPB404_RS01965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPB404_RS01975	COG4868	Belongs to the UPF0371 family
LPB404_RS01980	COG1363	Peptidase, m42
LPB404_RS01990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB404_RS01995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB404_RS02005	COG1609	Transcriptional regulator
LPB404_RS02010	COG4585	Histidine kinase
LPB404_RS02015	COG2197	response regulator
LPB404_RS02040	COG3716	PTS system mannose fructose sorbose family IID component
LPB404_RS02065	COG1136	(ABC) transporter
LPB404_RS02075	COG0745	RESPONSE REGULATOR receiver
LPB404_RS02080	COG5002	protein histidine kinase activity
LPB404_RS02085	COG1136	(ABC) transporter
LPB404_RS02090	COG0577	efflux transmembrane transporter activity
LPB404_RS02125	COG0582	viral genome integration into host DNA
LPB404_RS02135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPB404_RS02175	COG2264	protein methyltransferase activity
LPB404_RS02180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPB404_RS02185	COG0737	Belongs to the 5'-nucleotidase family
LPB404_RS02195	COG1490	D-aminoacyl-tRNA deacylase activity
LPB404_RS02230	COG3590	peptidase
LPB404_RS02240	COG1349	DNA-binding transcription factor activity
LPB404_RS02245	COG2390	Transcriptional regulator
LPB404_RS02250	COG1447	Phosphotransferase system cellobiose-specific component IIA
LPB404_RS02260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPB404_RS02265	COG1882	Formate acetyltransferase
LPB404_RS02315	COG4166	transmembrane transport
LPB404_RS02335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPB404_RS02340	COG2723	6-phospho-beta-galactosidase activity
LPB404_RS02360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPB404_RS02365	COG0561	phosphatase activity
LPB404_RS02385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB404_RS02390	COG0765	amino acid transport
LPB404_RS02395	COG0765	amino acid transport
LPB404_RS02400	COG1126	abc transporter atp-binding protein
LPB404_RS02420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPB404_RS02425	COG4589	Belongs to the CDS family
LPB404_RS02440	COG2176	DNA-directed DNA polymerase activity
LPB404_RS02445	COG1396	sequence-specific DNA binding
LPB404_RS02460	COG3041	Addiction module toxin RelE StbE family
LPB404_RS02475	COG2309	aminopeptidase activity
LPB404_RS02485	COG0351	phosphomethylpyrimidine kinase
LPB404_RS02490	COG4720	Psort location CytoplasmicMembrane, score
LPB404_RS02495	COG4475	Protein of unknown function (DUF436)
LPB404_RS02500	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPB404_RS02505	COG3343	RNA polymerase activity
LPB404_RS02520	COG0191	fructose-bisphosphate aldolase activity
LPB404_RS02610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LPB404_RS02620	COG1461	Dihydroxyacetone kinase
LPB404_RS02640	COG1131	(ABC) transporter
LPB404_RS02645	COG0842	Transport permease protein
LPB404_RS02650	COG4585	Histidine kinase
LPB404_RS02655	COG2197	response regulator
LPB404_RS02660	COG0028	Belongs to the TPP enzyme family
LPB404_RS02665	COG0440	acetolactate synthase activity
LPB404_RS02670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPB404_RS02675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LPB404_RS02690	COG1126	abc transporter atp-binding protein
LPB404_RS02695	COG0765	amino acid transport
LPB404_RS02705	COG1968	undecaprenyl-diphosphatase activity
LPB404_RS02710	COG4862	establishment of competence for transformation
LPB404_RS02715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPB404_RS02725	COG0719	Fe-S assembly protein
LPB404_RS02730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPB404_RS02740	COG0719	Fe-S assembly protein
LPB404_RS02750	COG1686	Belongs to the peptidase S11 family
LPB404_RS02755	COG4166	transmembrane transport
LPB404_RS02760	COG4166	transmembrane transport
LPB404_RS02765	COG0601	transmembrane transport
LPB404_RS02770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPB404_RS02775	COG0444	Belongs to the ABC transporter superfamily
LPB404_RS02780	COG4608	Belongs to the ABC transporter superfamily
LPB404_RS02810	COG0527	aspartate kinase activity
LPB404_RS02815	COG1024	Enoyl-CoA hydratase
LPB404_RS02835	COG2070	2-Nitropropane dioxygenase
LPB404_RS02840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPB404_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
LPB404_RS02850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPB404_RS02865	COG0439	Biotin carboxylase
LPB404_RS02870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPB404_RS02875	COG0825	malonyl-CoA metabolic process
LPB404_RS02890	COG3716	PTS system mannose fructose sorbose family IID component
LPB404_RS02895	COG3715	PTS system
LPB404_RS02905	COG1064	alcohol dehydrogenase
LPB404_RS02910	COG0561	phosphatase activity
LPB404_RS02915	COG2252	PERMEase
LPB404_RS02920	COG0802	atpase or kinase
LPB404_RS02930	COG1316	TRANSCRIPTIONal
LPB404_RS02940	COG0537	adenosine 5'-monophosphoramidase activity
LPB404_RS02945	COG1131	(ABC) transporter
LPB404_RS02960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPB404_RS02965	COG0779	Required for maturation of 30S ribosomal subunits
LPB404_RS02970	COG0195	Participates in both transcription termination and antitermination
LPB404_RS02975	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LPB404_RS02990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPB404_RS02995	COG1283	sodium-dependent phosphate transmembrane transporter activity
LPB404_RS03010	COG0656	L-ascorbic acid biosynthetic process
LPB404_RS03030	COG4224	UPF0291 protein
LPB404_RS03045	COG0768	penicillin binding
LPB404_RS03050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPB404_RS03055	COG0513	Belongs to the DEAD box helicase family
LPB404_RS03060	COG0765	amino acid transport
LPB404_RS03065	COG1126	abc transporter atp-binding protein
LPB404_RS03075	COG0492	ferredoxin-NADP+ reductase activity
LPB404_RS03080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPB404_RS03090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LPB404_RS03095	COG3579	cysteine-type endopeptidase activity
LPB404_RS03100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPB404_RS03105	COG3331	DNA recombination
LPB404_RS03110	COG4474	Belongs to the UPF0398 family
LPB404_RS03125	COG0116	Belongs to the methyltransferase superfamily
LPB404_RS03135	COG1854	S-ribosylhomocysteine lyase activity
LPB404_RS03140	COG1418	mRNA catabolic process
LPB404_RS03145	COG0194	GDP metabolic process
LPB404_RS03150	COG1758	RNA polymerase activity
LPB404_RS03155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPB404_RS03160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPB404_RS03165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPB404_RS03165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPB404_RS03170	COG0631	protein serine/threonine phosphatase activity
LPB404_RS03175	COG0515	serine threonine protein kinase
LPB404_RS03175	COG2815	serine threonine protein kinase
LPB404_RS03185	COG4585	Histidine kinase
LPB404_RS03190	COG2197	response regulator
LPB404_RS03200	COG1185	polyribonucleotide nucleotidyltransferase activity
LPB404_RS03210	COG1739	Uncharacterized protein family UPF0029
LPB404_RS03215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LPB404_RS03220	COG1040	competence protein
LPB404_RS03315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPB404_RS03320	COG0295	cytidine deaminase activity
LPB404_RS03345	COG0519	Catalyzes the synthesis of GMP from XMP
LPB404_RS03355	COG0525	valine-tRNA ligase activity
LPB404_RS03385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPB404_RS03395	COG0742	ribosomal rna small subunit methyltransferase
LPB404_RS03400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPB404_RS03405	COG3480	Lon protease (S16) C-terminal proteolytic domain
LPB404_RS03410	COG0785	Cytochrome C biogenesis protein
LPB404_RS03420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB404_RS03425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB404_RS03425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB404_RS03430	COG2207	Transcriptional regulator
LPB404_RS03430	COG4753	response regulator
LPB404_RS03435	COG2972	Histidine kinase
LPB404_RS03440	COG4470	Protein conserved in bacteria
LPB404_RS03445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPB404_RS03455	COG0133	tryptophan synthase activity
LPB404_RS03480	COG1187	pseudouridine synthase activity
LPB404_RS03485	COG1217	gtp-binding protein TYPA
LPB404_RS03505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPB404_RS03515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LPB404_RS03520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPB404_RS03525	COG1799	cell septum assembly
LPB404_RS03540	COG3599	regulation of cell shape
LPB404_RS03545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPB404_RS03560	COG0494	nUDIX hydrolase
LPB404_RS03565	COG0542	response to heat
LPB404_RS03570	COG4703	Protein of unknown function (DUF1797)
LPB404_RS03575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPB404_RS03580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPB404_RS03585	COG1570	exodeoxyribonuclease VII activity
LPB404_RS03590	COG1722	exodeoxyribonuclease VII activity
LPB404_RS03600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LPB404_RS03605	COG1438	arginine binding
LPB404_RS03610	COG0497	DNA recombination
LPB404_RS03615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LPB404_RS03620	COG1307	EDD domain protein, DegV family
LPB404_RS03640	COG0588	phosphoglycerate mutase activity
LPB404_RS03645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB404_RS03645	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB404_RS03650	COG3655	Transcriptional regulator
LPB404_RS03670	COG0745	RESPONSE REGULATOR receiver
LPB404_RS03690	COG0464	growth
LPB404_RS03695	COG1136	(ABC) transporter
LPB404_RS03700	COG0577	efflux transmembrane transporter activity
LPB404_RS03715	COG1136	(ABC) transporter
LPB404_RS03720	COG0577	efflux transmembrane transporter activity
LPB404_RS03725	COG4166	transmembrane transport
LPB404_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
LPB404_RS03870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPB404_RS03875	COG0494	nUDIX hydrolase
LPB404_RS03885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LPB404_RS03895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPB404_RS03910	COG0708	Exodeoxyribonuclease III
LPB404_RS03915	COG0768	penicillin binding
LPB404_RS03920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPB404_RS03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPB404_RS03960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LPB404_RS03980	COG0513	Belongs to the DEAD box helicase family
LPB404_RS03985	COG1349	DNA-binding transcription factor activity
LPB404_RS04000	COG3775	system Galactitol-specific IIC component
LPB404_RS04015	COG0698	ribose 5-phosphate isomerase
LPB404_RS04020	COG1105	Belongs to the carbohydrate kinase PfkB family
LPB404_RS04025	COG3684	Belongs to the aldolase LacD family
LPB404_RS04040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPB404_RS04045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPB404_RS04050	COG0204	Acyl-transferase
LPB404_RS04055	COG1555	photosystem II stabilization
LPB404_RS04055	COG1596	polysaccharide export
LPB404_RS04070	COG1466	dna polymerase III delta subunit
LPB404_RS04075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPB404_RS04080	COG0433	COG0433 Predicted ATPase
LPB404_RS04090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPB404_RS04095	COG2235	arginine
LPB404_RS04100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPB404_RS04105	COG0549	Belongs to the carbamate kinase family
LPB404_RS04110	COG1288	antiporter activity
LPB404_RS04115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPB404_RS04125	COG1438	arginine binding
LPB404_RS04130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPB404_RS04150	COG1686	Belongs to the peptidase S11 family
LPB404_RS04175	COG4122	O-methyltransferase activity
LPB404_RS04180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB404_RS04190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPB404_RS04195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB404_RS04200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB404_RS04205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LPB404_RS04220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LPB404_RS04230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LPB404_RS04235	COG0297	glycogen (starch) synthase activity
LPB404_RS04240	COG3064	Membrane
LPB404_RS04250	COG0356	it plays a direct role in the translocation of protons across the membrane
LPB404_RS04255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPB404_RS04260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB404_RS04265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPB404_RS04270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPB404_RS04290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPB404_RS04315	COG0488	(ABC) transporter
LPB404_RS04340	COG3442	glutamine amidotransferase
LPB404_RS04345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPB404_RS04350	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LPB404_RS04360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB404_RS04375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPB404_RS04385	COG0251	oxidation-reduction process
LPB404_RS04390	COG1660	Displays ATPase and GTPase activities
LPB404_RS04395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LPB404_RS04400	COG1481	regulation of sporulation
LPB404_RS04405	COG0492	ferredoxin-NADP+ reductase activity
LPB404_RS04420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LPB404_RS04425	COG1970	mechanosensitive ion channel activity
LPB404_RS04430	COG0358	DNA primase activity
LPB404_RS04435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPB404_RS04440	COG2151	metal-sulfur cluster biosynthetic enzyme
LPB404_RS04445	COG1131	(ABC) transporter
LPB404_RS04475	COG0469	pyruvate kinase activity
LPB404_RS04480	COG0681	Belongs to the peptidase S26 family
LPB404_RS04485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LPB404_RS04490	COG0210	DNA helicase
LPB404_RS04505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPB404_RS04510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB404_RS04535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPB404_RS04540	COG0196	riboflavin kinase activity
LPB404_RS04545	COG1393	Belongs to the ArsC family
LPB404_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
LPB404_RS04560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LPB404_RS04560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPB404_RS04565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPB404_RS04570	COG0573	inorganic phosphate transmembrane transporter activity
LPB404_RS04575	COG0581	inorganic phosphate transmembrane transporter activity
LPB404_RS04580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPB404_RS04585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPB404_RS04590	COG0704	Plays a role in the regulation of phosphate uptake
LPB404_RS04600	COG1268	BioY protein
LPB404_RS04610	COG0745	RESPONSE REGULATOR receiver
LPB404_RS04615	COG5002	protein histidine kinase activity
LPB404_RS04625	COG0726	polysaccharide deacetylase
LPB404_RS04650	COG1956	GAF domain-containing protein
LPB404_RS04655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPB404_RS04665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPB404_RS04665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPB404_RS04670	COG1609	Transcriptional regulator
LPB404_RS04685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPB404_RS04705	COG1174	glycine betaine transport
LPB404_RS04720	COG1230	cation diffusion facilitator family transporter
LPB404_RS04730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LPB404_RS04740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LPB404_RS04745	COG0569	domain protein
LPB404_RS04755	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LPB404_RS04760	COG1074	ATP-dependent DNA helicase activity
LPB404_RS04780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPB404_RS04795	COG0300	oxidoreductase activity
LPB404_RS04810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPB404_RS04810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LPB404_RS04815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPB404_RS04820	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LPB404_RS04830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LPB404_RS04835	COG0625	glutathione transferase activity
LPB404_RS04840	COG2384	SAM-dependent methyltransferase
LPB404_RS04845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LPB404_RS04850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPB404_RS04860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LPB404_RS04870	COG1088	dTDP-glucose 4,6-dehydratase activity
LPB404_RS04885	COG1104	cysteine desulfurase activity
LPB404_RS04905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPB404_RS04965	COG0583	DNA-binding transcription factor activity
LPB404_RS04970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPB404_RS04975	COG0564	pseudouridine synthase activity
LPB404_RS04985	COG0488	(ABC) transporter
LPB404_RS04990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB404_RS05005	COG0647	UMP catabolic process
LPB404_RS05055	COG1573	uracil-dna glycosylase
LPB404_RS05060	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
LPB404_RS05065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB404_RS05065	COG0425	Belongs to the sulfur carrier protein TusA family
LPB404_RS05095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LPB404_RS05100	COG0716	FMN binding
LPB404_RS05110	COG0038	chloride channel
LPB404_RS05115	COG0335	large ribosomal subunit rRNA binding
LPB404_RS05150	COG1518	maintenance of DNA repeat elements
LPB404_RS05155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LPB404_RS05165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPB404_RS05170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LPB404_RS05175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LPB404_RS05185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LPB404_RS05195	COG0813	purine-nucleoside phosphorylase activity
LPB404_RS05210	COG0583	DNA-binding transcription factor activity
LPB404_RS05220	COG0543	2 iron, 2 sulfur cluster binding
LPB404_RS05225	COG0167	dihydroorotate dehydrogenase activity
LPB404_RS05230	COG0284	orotidine-5'-phosphate decarboxylase activity
LPB404_RS05255	COG1051	belongs to the nudix hydrolase family
LPB404_RS05260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPB404_RS05280	COG0473	3-isopropylmalate dehydrogenase activity
LPB404_RS05295	COG0066	3-isopropylmalate dehydratase activity
LPB404_RS05305	COG2323	membrane
LPB404_RS05320	COG0187	DNA topoisomerase II activity
LPB404_RS05340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LPB404_RS05345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPB404_RS05365	COG0539	negative regulation of cytoplasmic translation
LPB404_RS05375	COG0039	L-malate dehydrogenase activity
LPB404_RS05380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LPB404_RS05385	COG3764	Sortase (surface protein transpeptidase)
LPB404_RS05395	COG2003	Belongs to the UPF0758 family
LPB404_RS05415	COG1104	cysteine desulfurase activity
LPB404_RS05420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPB404_RS05430	COG2357	RelA SpoT domain protein
LPB404_RS05440	COG0564	pseudouridine synthase activity
LPB404_RS05445	COG0280	phosphate acetyltransferase
LPB404_RS05450	COG1194	a g-specific adenine glycosylase
LPB404_RS05460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB404_RS05465	COG4684	Psort location CytoplasmicMembrane, score
LPB404_RS05470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPB404_RS05480	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LPB404_RS05500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPB404_RS05525	COG1940	carbohydrate kinase activity
LPB404_RS05530	COG0758	DNA mediated transformation
LPB404_RS05535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPB404_RS05570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LPB404_RS05575	COG0022	dehydrogenase e1 component
LPB404_RS05580	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB404_RS05585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB404_RS05590	COG0095	Lipoate-protein ligase
LPB404_RS05655	COG3458	cephalosporin-C deacetylase activity
LPB404_RS05665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPB404_RS05675	COG2188	Transcriptional regulator
LPB404_RS05690	COG0741	lytic transglycosylase activity
LPB404_RS05705	COG0456	acetyltransferase
LPB404_RS05710	COG0009	L-threonylcarbamoyladenylate synthase
LPB404_RS05715	COG2890	protein-(glutamine-N5) methyltransferase activity
LPB404_RS05720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPB404_RS05730	COG1435	thymidine kinase activity
LPB404_RS05735	COG1942	4-Oxalocrotonate Tautomerase
LPB404_RS05740	COG0534	Mate efflux family protein
LPB404_RS05745	COG2233	PERMEase
LPB404_RS05765	COG0110	maltose O-acetyltransferase activity
LPB404_RS05770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB404_RS05775	COG0805	protein transport
LPB404_RS05780	COG0672	)-iron permease
LPB404_RS05785	COG2837	iron assimilation
LPB404_RS05790	COG2822	iron ion transport
LPB404_RS05795	COG0038	chloride channel
LPB404_RS05815	COG1053	succinate dehydrogenase
LPB404_RS05815	COG3976	FMN-binding domain protein
LPB404_RS05815	COG0431	NADPH-dependent FMN reductase
LPB404_RS05820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB404_RS05825	COG0785	Cytochrome C biogenesis protein
LPB404_RS05845	COG1132	(ABC) transporter
LPB404_RS05870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPB404_RS05880	COG1388	LysM domain
LPB404_RS05880	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPB404_RS05885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPB404_RS05895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LPB404_RS05910	COG1940	carbohydrate kinase activity
LPB404_RS05920	COG0488	(ABC) transporter
LPB404_RS05925	COG0617	tRNA 3'-terminal CCA addition
LPB404_RS05930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPB404_RS05935	COG1307	EDD domain protein, DegV family
LPB404_RS05945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPB404_RS05945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPB404_RS05945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPB404_RS05950	COG1105	Belongs to the carbohydrate kinase PfkB family
LPB404_RS05955	COG1349	DNA-binding transcription factor activity
LPB404_RS05985	COG2267	carboxylic ester hydrolase activity
LPB404_RS05990	COG1837	Belongs to the UPF0109 family
LPB404_RS06005	COG1011	Hydrolase
LPB404_RS06030	COG0561	phosphatase activity
LPB404_RS06035	COG2195	Cleaves the N-terminal amino acid of tripeptides
LPB404_RS06040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPB404_RS06045	COG0505	Belongs to the CarA family
LPB404_RS06050	COG0540	Belongs to the ATCase OTCase family
LPB404_RS06055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LPB404_RS06065	COG2824	Alkylphosphonate utilization operon protein PhnA
LPB404_RS06080	COG1051	belongs to the nudix hydrolase family
LPB404_RS06115	COG1131	(ABC) transporter
LPB404_RS06135	COG0765	amino acid transport
LPB404_RS06140	COG1126	abc transporter atp-binding protein
LPB404_RS06150	COG1132	(ABC) transporter
LPB404_RS06165	COG0017	Asparaginyl-tRNA synthetase
LPB404_RS06190	COG0436	Aminotransferase
LPB404_RS06195	COG1846	Transcriptional regulator
LPB404_RS06210	COG1272	protein, Hemolysin III
LPB404_RS06215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPB404_RS06230	COG3142	Participates in the control of copper homeostasis
LPB404_RS06245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPB404_RS06255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPB404_RS06370	COG0488	(ABC) transporter
LPB404_RS06395	COG0135	phosphoribosylanthranilate isomerase activity
LPB404_RS06410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPB404_RS06420	COG0077	Prephenate dehydratase
LPB404_RS06425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LPB404_RS06430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LPB404_RS06435	COG3679	Belongs to the UPF0342 family
LPB404_RS06440	COG0287	Prephenate dehydrogenase
LPB404_RS06445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPB404_RS06455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPB404_RS06460	COG0710	3-dehydroquinate dehydratase activity
LPB404_RS06465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPB404_RS06470	COG1368	sulfuric ester hydrolase activity
LPB404_RS06475	COG1523	belongs to the glycosyl hydrolase 13 family
LPB404_RS06480	COG1597	lipid kinase activity
LPB404_RS06485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPB404_RS06490	COG4708	membrane
LPB404_RS06495	COG2246	polysaccharide biosynthetic process
LPB404_RS06505	COG1846	Transcriptional regulator
LPB404_RS06515	COG0024	Methionine aminopeptidase
LPB404_RS06520	COG4109	DRTGG domain
LPB404_RS06525	COG0519	Catalyzes the synthesis of GMP from XMP
LPB404_RS06530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPB404_RS06540	COG2217	Heavy metal translocating P-type atpase
LPB404_RS06575	COG0765	amino acid transport
LPB404_RS06580	COG1126	abc transporter atp-binding protein
LPB404_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB404_RS06590	COG2131	deaminase
LPB404_RS06600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LPB404_RS06610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPB404_RS06630	COG1368	sulfuric ester hydrolase activity
LPB404_RS06650	COG0463	Glycosyl transferase, family 2
LPB404_RS06670	COG1442	glycosyl transferase family 8
LPB404_RS06670	COG1216	Glycosyl transferase, family 2
LPB404_RS06690	COG0463	Glycosyl transferase, family 2
LPB404_RS06695	COG1216	Glycosyl transferase, family 2
LPB404_RS06700	COG1216	Glycosyl transferase, family 2
LPB404_RS06715	COG1091	dTDP-4-dehydrorhamnose reductase activity
LPB404_RS06730	COG1177	transmembrane transport
LPB404_RS06735	COG1175	transmembrane transport
LPB404_RS06740	COG3842	ATPase activity
LPB404_RS06745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPB404_RS06760	COG0460	homoserine dehydrogenase
LPB404_RS06765	COG0726	polysaccharide deacetylase
LPB404_RS06770	COG1079	Belongs to the binding-protein-dependent transport system permease family
LPB404_RS06775	COG4603	Belongs to the binding-protein-dependent transport system permease family
LPB404_RS06780	COG3845	ABC transporter
LPB404_RS06785	COG1744	ABC transporter substrate-binding protein PnrA-like
LPB404_RS06795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LPB404_RS06800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LPB404_RS06805	COG2813	Specifically methylates the guanine in position
LPB404_RS06810	COG1072	(Pantothenic acid kinase))
LPB404_RS06815	COG0268	Binds directly to 16S ribosomal RNA
LPB404_RS06840	COG1131	(ABC) transporter
LPB404_RS06855	COG3118	belongs to the thioredoxin family
LPB404_RS06865	COG4166	transmembrane transport
LPB404_RS06870	COG0159	tryptophan synthase activity
LPB404_RS06880	COG0135	phosphoribosylanthranilate isomerase activity
LPB404_RS06895	COG0512	Glutamine amidotransferase of anthranilate synthase
LPB404_RS06900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB404_RS06905	COG1363	Peptidase, m42
LPB404_RS06925	COG2514	catechol 2,3-dioxygenase activity
LPB404_RS06935	COG3620	sequence-specific DNA binding
LPB404_RS06965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPB404_RS06980	COG1132	(ABC) transporter
LPB404_RS06985	COG1132	(ABC) transporter
LPB404_RS07010	COG4989	oxidoreductase activity
LPB404_RS07015	COG1668	transmembrane transport
LPB404_RS07020	COG4152	abc transporter atp-binding protein
LPB404_RS07030	COG1476	TRANSCRIPTIONal
LPB404_RS07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB404_RS07040	COG0072	phenylalanine-tRNA ligase activity
LPB404_RS07065	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LPB404_RS07070	COG3527	Alpha-acetolactate decarboxylase
LPB404_RS07080	COG0628	permease
LPB404_RS07085	COG2706	6-phosphogluconolactonase activity
LPB404_RS07110	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LPB404_RS07115	COG0187	DNA topoisomerase II activity
LPB404_RS07130	COG0772	Belongs to the SEDS family
LPB404_RS07140	COG1199	ATP-dependent helicase activity
LPB404_RS07140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPB404_RS07150	COG2177	Part of the ABC transporter FtsEX involved in
LPB404_RS07155	COG2884	Cell division ATP-binding protein ftsE
LPB404_RS07170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPB404_RS07185	COG1078	dGTPase activity
LPB404_RS07195	COG2348	transferase activity, transferring amino-acyl groups
LPB404_RS07210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPB404_RS07215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPB404_RS07220	COG0772	Belongs to the SEDS family
LPB404_RS07230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LPB404_RS07235	COG0588	phosphoglycerate mutase activity
LPB404_RS07240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPB404_RS07245	COG0577	efflux transmembrane transporter activity
LPB404_RS07250	COG1136	(ABC) transporter
LPB404_RS07260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB404_RS07265	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LPB404_RS07270	COG4443	Transcriptional Coactivator p15 (PC4)
LPB404_RS07280	COG0826	peptidase U32
LPB404_RS07305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPB404_RS07310	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LPB404_RS07325	COG3091	SprT-like family
LPB404_RS07330	COG2183	response to ionizing radiation
LPB404_RS07340	COG0701	Predicted permease
LPB404_RS07345	COG3689	TIGRFAM TIGR03943 family protein
LPB404_RS07350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPB404_RS07415	COG3209	COG3209 Rhs family protein
LPB404_RS07630	COG0552	protein localization to endoplasmic reticulum
LPB404_RS07635	COG0561	phosphatase activity
LPB404_RS07640	COG0561	phosphatase activity
LPB404_RS07645	COG1196	nuclear chromosome segregation
LPB404_RS07650	COG0571	ribonuclease III activity
LPB404_RS07655	COG2832	Protein of unknown function (DUF454)
LPB404_RS07660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPB404_RS07665	COG5002	protein histidine kinase activity
LPB404_RS07670	COG0745	RESPONSE REGULATOR receiver
LPB404_RS07680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPB404_RS07685	COG0438	transferase activity, transferring glycosyl groups
LPB404_RS07695	COG1609	Transcriptional regulator
LPB404_RS07735	COG0737	Belongs to the 5'-nucleotidase family
LPB404_RS07745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB404_RS07745	COG0425	Belongs to the sulfur carrier protein TusA family
LPB404_RS07750	COG1937	Protein conserved in bacteria
LPB404_RS07770	COG1346	cytolysis
LPB404_RS07775	COG1380	Effector of murein hydrolase LrgA
LPB404_RS07795	COG0557	exoribonuclease II activity
LPB404_RS07805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPB404_RS07810	COG2814	Major facilitator Superfamily
LPB404_RS07815	COG0237	dephospho-CoA kinase activity
LPB404_RS07820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPB404_RS07825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPB404_RS07830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPB404_RS07840	COG1132	(ABC) transporter
LPB404_RS07845	COG1132	(ABC) transporter
LPB404_RS07860	COG0686	Belongs to the AlaDH PNT family
LPB404_RS07865	COG1702	phosphate starvation-inducible protein PhoH
LPB404_RS07885	COG0528	UMP kinase activity
LPB404_RS07890	COG0081	regulation of translation
LPB404_RS07895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPB404_RS07905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPB404_RS07910	COG0346	lactoylglutathione lyase activity
LPB404_RS07915	COG1674	ftsk spoiiie
LPB404_RS07915	COG0697	spore germination
LPB404_RS07935	COG4555	ABC transporter
LPB404_RS07945	COG0488	(ABC) transporter
LPB404_RS07970	COG1393	Belongs to the ArsC family
LPB404_RS07975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPB404_RS07990	COG4467	Involved in initiation control of chromosome replication
LPB404_RS07995	COG0470	DNA polymerase III
LPB404_RS08000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LPB404_RS08005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LPB404_RS08010	COG0517	IMP dehydrogenase activity
LPB404_RS08030	COG0559	Belongs to the binding-protein-dependent transport system permease family
LPB404_RS08050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPB404_RS08055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPB404_RS08060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LPB404_RS08065	COG0626	cystathionine gamma-synthase activity
LPB404_RS08070	COG2244	polysaccharide biosynthetic process
LPB404_RS08075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPB404_RS08095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LPB404_RS08100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPB404_RS08105	COG4120	Belongs to the binding-protein-dependent transport system permease family
LPB404_RS08120	COG1253	flavin adenine dinucleotide binding
LPB404_RS08125	COG3711	transcriptional antiterminator
LPB404_RS08130	COG0628	permease
LPB404_RS08135	COG1119	ATPase activity
LPB404_RS08140	COG0025	NhaP-type Na H and K H
LPB404_RS08150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LPB404_RS08155	COG1242	4 iron, 4 sulfur cluster binding
LPB404_RS08165	COG0671	phosphoesterase, PA-phosphatase related
LPB404_RS08170	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LPB404_RS08180	COG0569	domain protein
LPB404_RS08185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LPB404_RS08195	COG1187	pseudouridine synthase activity
LPB404_RS08200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPB404_RS08205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPB404_RS08210	COG4974	Belongs to the 'phage' integrase family
LPB404_RS08215	COG0517	IMP dehydrogenase activity
LPB404_RS08225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPB404_RS08230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LPB404_RS08255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB404_RS08260	COG1254	Belongs to the acylphosphatase family
LPB404_RS08275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPB404_RS08300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPB404_RS08315	COG0778	Nitroreductase
LPB404_RS08320	COG1484	DNA-dependent DNA replication
LPB404_RS08330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPB404_RS08340	COG2190	(PTS) system
LPB404_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPB404_RS08340	COG1263	PTS System
LPB404_RS08345	COG0745	RESPONSE REGULATOR receiver
LPB404_RS08350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LPB404_RS08355	COG2268	Band 7 protein
LPB404_RS08380	COG0501	Belongs to the peptidase M48B family
LPB404_RS08385	COG1704	LemA family
LPB404_RS08390	COG0357	Ribosomal RNA small subunit methyltransferase G
LPB404_RS08395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPB404_RS08400	COG4221	oxidoreductase activity
LPB404_RS08410	COG1122	ATPase activity
LPB404_RS08470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPB404_RS08485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPB404_RS08490	COG1473	amidohydrolase
LPB404_RS08495	COG0217	transcriptional regulatory protein
LPB404_RS08505	COG2226	methyltransferase
LPB404_RS08510	COG0799	negative regulation of ribosome biogenesis
LPB404_RS08515	COG1335	isochorismatase
LPB404_RS08520	COG1713	HD superfamily hydrolase involved in NAD metabolism
LPB404_RS08525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPB404_RS08530	COG1534	Rna-binding protein
LPB404_RS08535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LPB404_RS08540	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LPB404_RS08555	COG1063	alcohol dehydrogenase
LPB404_RS08575	COG1335	isochorismatase
LPB404_RS08580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LPB404_RS08585	COG0436	Aminotransferase
LPB404_RS08590	COG0589	response to stress
LPB404_RS08595	COG0561	phosphatase activity
LPB404_RS08600	COG0252	asparaginase activity
LPB404_RS08605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPB404_RS08615	COG0736	holo-[acyl-carrier-protein] synthase activity
LPB404_RS08620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPB404_RS08625	COG0653	protein targeting
LPB404_RS08630	COG0531	amino acid
LPB404_RS08645	COG1482	cell wall glycoprotein biosynthetic process
LPB404_RS08650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPB404_RS08660	COG0242	peptide deformylase activity
LPB404_RS08665	COG1940	carbohydrate kinase activity
LPB404_RS08670	COG1263	PTS System
LPB404_RS08670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPB404_RS08670	COG2190	(PTS) system
LPB404_RS08675	COG1621	beta-fructofuranosidase activity
LPB404_RS08680	COG1609	Transcriptional regulator
LPB404_RS08700	COG0006	proline dipeptidase activity
LPB404_RS08705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPB404_RS08725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPB404_RS08730	COG0629	single-stranded DNA binding
LPB404_RS08735	COG0360	Binds together with S18 to 16S ribosomal RNA
LPB404_RS08755	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LPB404_RS08765	COG1228	amidohydrolase
LPB404_RS08770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPB404_RS08780	COG3404	Formiminotransferase-cyclodeaminase
LPB404_RS08795	COG0531	amino acid
LPB404_RS08800	COG2986	histidine ammonia-lyase
LPB404_RS08820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LPB404_RS08825	COG0366	Alpha amylase catalytic
LPB404_RS08835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB404_RS08855	COG2205	protein histidine kinase activity
LPB404_RS08860	COG0745	RESPONSE REGULATOR receiver
LPB404_RS08870	COG2723	6-phospho-beta-galactosidase activity
LPB404_RS08880	COG0028	Belongs to the TPP enzyme family
LPB404_RS08890	COG0561	phosphatase activity
LPB404_RS08895	COG2207	Transcriptional regulator
LPB404_RS08900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPB404_RS08905	COG2843	Capsule synthesis protein
LPB404_RS08910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB404_RS08910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB404_RS08920	COG0167	dihydroorotate dehydrogenase activity
LPB404_RS08925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LPB404_RS08930	COG0484	heat shock protein binding
LPB404_RS08945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPB404_RS08960	COG0588	phosphoglycerate mutase activity
LPB404_RS08965	COG0588	phosphoglycerate mutase activity
LPB404_RS08975	COG3830	Belongs to the UPF0237 family
LPB404_RS08985	COG3237	CsbD-like
LPB404_RS09025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPB404_RS09055	COG2217	Heavy metal translocating P-type atpase
LPB404_RS09095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LPB404_RS09105	COG3688	RNA-binding protein containing a PIN domain
LPB404_RS09125	COG0366	Alpha amylase catalytic
LPB404_RS09130	COG3842	ATPase activity
LPB404_RS09140	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LPB404_RS09145	COG0215	cysteine-tRNA ligase activity
LPB404_RS09160	COG1045	serine acetyltransferase
LPB404_RS09175	COG1164	Oligoendopeptidase f
LPB404_RS09185	COG3118	belongs to the thioredoxin family
LPB404_RS09195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPB404_RS09230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPB404_RS09245	COG0791	NLP P60 protein
LPB404_RS09245	COG0741	lytic transglycosylase activity
LPB404_RS09275	COG2946	Replication initiation factor
LPB404_RS09285	COG1674	ftsk spoiiie
LPB404_RS09305	COG1187	pseudouridine synthase activity
LPB404_RS09315	COG0668	transmembrane transport
LPB404_RS09325	COG1115	amino acid carrier protein
LPB404_RS09350	COG0386	Belongs to the glutathione peroxidase family
LPB404_RS09360	COG0681	Belongs to the peptidase S26 family
LPB404_RS09365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPB404_RS09370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPB404_RS09375	COG1882	Formate acetyltransferase
LPB404_RS09395	COG3425	synthase
LPB404_RS09420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LPB404_RS09450	COG2176	DNA-directed DNA polymerase activity
LPB404_RS09460	COG1914	H( )-stimulated, divalent metal cation uptake system
LPB404_RS09470	COG2081	HI0933 family
LPB404_RS09480	COG0789	Transcriptional regulator
LPB404_RS09485	COG0733	neurotransmitter:sodium symporter activity
LPB404_RS09515	COG1214	PFAM Peptidase M22, glycoprotease
LPB404_RS09520	COG5503	Protein of unknown function (DUF1447)
LPB404_RS09530	COG0174	glutamine synthetase
LPB404_RS09535	COG0789	Transcriptional regulator
LPB404_RS09545	COG0126	phosphoglycerate kinase activity
LPB404_RS09575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPB404_RS09580	COG3481	metal-dependent phosphohydrolase, HD sub domain
LPB404_RS09590	COG1564	THIamine pyrophosphokinase
LPB404_RS09600	COG1162	GTPase activity
LPB404_RS09635	COG0084	hydrolase, TatD family'
LPB404_RS09640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LPB404_RS09650	COG1847	R3H domain protein
LPB404_RS09655	COG0706	membrane insertase activity
LPB404_RS09660	COG0594	ribonuclease P activity
LPB404_RS09695	COG1129	ABC transporter
LPB404_RS09715	COG0463	Glycosyl transferase, family 2
LPB404_RS09760	COG0756	dUTP diphosphatase activity
LPB404_RS09765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPB404_RS09770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPB404_RS09775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPB404_RS09790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPB404_RS09855	COG3290	protein histidine kinase activity