locus-tag	class	description
SR187_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SR187_RS00010	COG0592	DNA-directed DNA polymerase activity
SR187_RS00055	COG1131	(ABC) transporter
SR187_RS00060	COG0012	GTP binding
SR187_RS00065	COG0193	aminoacyl-tRNA hydrolase activity
SR187_RS00070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SR187_RS00075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SR187_RS00095	COG0037	tRNA processing
SR187_RS00105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SR187_RS00215	COG1792	Involved in formation and maintenance of cell shape
SR187_RS00230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SR187_RS00235	COG0436	Aminotransferase
SR187_RS00240	COG1381	Involved in DNA repair and RecF pathway recombination
SR187_RS00245	COG0416	fatty acid biosynthetic process
SR187_RS00250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SR187_RS00255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SR187_RS00260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SR187_RS00275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SR187_RS00285	COG0138	bifunctional purine biosynthesis protein purh
SR187_RS00295	COG0151	Belongs to the GarS family
SR187_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SR187_RS00315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SR187_RS00350	COG2274	protein secretion by the type I secretion system
SR187_RS00355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR187_RS00360	COG2255	four-way junction helicase activity
SR187_RS00365	COG0546	phosphoglycolate phosphatase activity
SR187_RS00375	COG0285	dihydrofolate synthase activity
SR187_RS00390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SR187_RS00395	COG0632	four-way junction helicase activity
SR187_RS00400	COG0519	Catalyzes the synthesis of GMP from XMP
SR187_RS00415	COG1393	Belongs to the ArsC family
SR187_RS00420	COG4472	Bacterial protein of unknown function (DUF965)
SR187_RS00425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SR187_RS00430	COG3906	Belongs to the UPF0473 family
SR187_RS00445	COG0051	transcription antitermination factor activity, RNA binding
SR187_RS00450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SR187_RS00455	COG0088	Forms part of the polypeptide exit tunnel
SR187_RS00460	COG0089	rRNA binding
SR187_RS00465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SR187_RS00470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SR187_RS00475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SR187_RS00480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SR187_RS00485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SR187_RS00490	COG0255	Belongs to the universal ribosomal protein uL29 family
SR187_RS00495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SR187_RS00500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SR187_RS00505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SR187_RS00510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SR187_RS00520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SR187_RS00525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SR187_RS00530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SR187_RS00535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SR187_RS00540	COG1841	ribosomal large subunit assembly
SR187_RS00550	COG0201	protein transport
SR187_RS00555	COG0563	adenylate kinase activity
SR187_RS00560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SR187_RS00565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SR187_RS00570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SR187_RS00580	COG0202	RNA polymerase activity
SR187_RS00715	COG1121	(ABC) transporter
SR187_RS00720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SR187_RS00725	COG0803	Belongs to the bacterial solute-binding protein 9 family
SR187_RS00725	COG3443	Belongs to the bacterial solute-binding protein 9 family
SR187_RS00735	COG2801	Transposase and inactivated derivatives
SR187_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SR187_RS00765	COG0085	RNA polymerase activity
SR187_RS00775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SR187_RS00785	COG1619	proteins homologs of microcin C7 resistance protein MccF
SR187_RS00790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SR187_RS00795	COG1459	type II secretion system
SR187_RS00800	COG4537	Required for transformation and DNA binding
SR187_RS00830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SR187_RS00840	COG0285	dihydrofolate synthase activity
SR187_RS00845	COG1363	Peptidase, m42
SR187_RS00855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SR187_RS00860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SR187_RS00895	COG0049	tRNA binding
SR187_RS00905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SR187_RS00935	COG2188	Transcriptional regulator
SR187_RS00940	COG1979	alcohol dehydrogenase
SR187_RS00945	COG0656	L-ascorbic acid biosynthetic process
SR187_RS00970	COG0789	Transcriptional regulator
SR187_RS00975	COG0174	glutamine synthetase
SR187_RS00990	COG1396	sequence-specific DNA binding
SR187_RS01000	COG1214	PFAM Peptidase M22, glycoprotease
SR187_RS01010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SR187_RS01015	COG2207	Transcriptional regulator
SR187_RS01025	COG1175	transmembrane transport
SR187_RS01030	COG0395	ABC-type sugar transport system, permease component
SR187_RS01055	COG1131	(ABC) transporter
SR187_RS01060	COG2081	HI0933 family
SR187_RS01070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SR187_RS01075	COG0584	glycerophosphoryl diester phosphodiesterase
SR187_RS01080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SR187_RS01085	COG2222	sugar isomerase
SR187_RS01090	COG2936	dipeptidyl-peptidase activity
SR187_RS01100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SR187_RS01120	COG0745	RESPONSE REGULATOR receiver
SR187_RS01125	COG5002	protein histidine kinase activity
SR187_RS01160	COG1882	Formate acetyltransferase
SR187_RS01175	COG0745	RESPONSE REGULATOR receiver
SR187_RS01180	COG0642	Histidine kinase
SR187_RS01180	COG5002	protein histidine kinase activity
SR187_RS01185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SR187_RS01190	COG0785	Cytochrome C biogenesis protein
SR187_RS01200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SR187_RS01205	COG0681	Belongs to the peptidase S26 family
SR187_RS01220	COG0366	Alpha amylase catalytic
SR187_RS01225	COG1263	PTS System
SR187_RS01225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR187_RS01230	COG2188	Transcriptional regulator
SR187_RS01245	COG1193	negative regulation of DNA recombination
SR187_RS01265	COG3118	belongs to the thioredoxin family
SR187_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
SR187_RS01275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SR187_RS01275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SR187_RS01280	COG1115	amino acid carrier protein
SR187_RS01285	COG0668	transmembrane transport
SR187_RS01290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SR187_RS01295	COG0167	dihydroorotate dehydrogenase activity
SR187_RS01315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SR187_RS01340	COG0433	COG0433 Predicted ATPase
SR187_RS01350	COG2801	Transposase and inactivated derivatives
SR187_RS01385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SR187_RS01390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SR187_RS01395	COG0124	histidyl-tRNA synthetase
SR187_RS01410	COG1064	alcohol dehydrogenase
SR187_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
SR187_RS01415	COG1454	alcohol dehydrogenase
SR187_RS01425	COG4988	ABC transporter
SR187_RS01430	COG1132	(ABC) transporter
SR187_RS01445	COG1129	ABC transporter
SR187_RS01470	COG1304	FMN binding
SR187_RS01495	COG1420	regulation of RNA biosynthetic process
SR187_RS01500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SR187_RS01505	COG0443	Heat shock 70 kDa protein
SR187_RS01515	COG0484	heat shock protein binding
SR187_RS01530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SR187_RS01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR187_RS01565	COG0765	amino acid transport
SR187_RS01570	COG2217	Heavy metal translocating P-type atpase
SR187_RS01585	COG0351	phosphomethylpyrimidine kinase
SR187_RS01595	COG4475	Protein of unknown function (DUF436)
SR187_RS01605	COG0544	peptidyl-prolyl cis-trans isomerase activity
SR187_RS01610	COG0803	Belongs to the bacterial solute-binding protein 9 family
SR187_RS01615	COG3343	RNA polymerase activity
SR187_RS01620	COG0504	CTP synthase activity
SR187_RS01630	COG0191	fructose-bisphosphate aldolase activity
SR187_RS01635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SR187_RS01705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SR187_RS01710	COG0252	asparaginase activity
SR187_RS01725	COG0589	response to stress
SR187_RS01730	COG0436	Aminotransferase
SR187_RS01735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SR187_RS01745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SR187_RS01750	COG0154	amidase activity
SR187_RS01755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SR187_RS01760	COG1609	Transcriptional regulator
SR187_RS01765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SR187_RS01785	COG3142	Participates in the control of copper homeostasis
SR187_RS01795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SR187_RS01800	COG1534	Rna-binding protein
SR187_RS01805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SR187_RS01810	COG1713	HD superfamily hydrolase involved in NAD metabolism
SR187_RS01815	COG0799	negative regulation of ribosome biogenesis
SR187_RS01820	COG2226	methyltransferase
SR187_RS01835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SR187_RS01840	COG0789	Transcriptional regulator
SR187_RS01845	COG0242	peptide deformylase activity
SR187_RS01855	COG1640	4-alpha-glucanotransferase
SR187_RS01860	COG0058	SHG alpha-glucan phosphorylase activity
SR187_RS01875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR187_RS01875	COG1263	PTS System
SR187_RS01875	COG2190	(PTS) system
SR187_RS01890	COG0217	transcriptional regulatory protein
SR187_RS01895	COG1054	Belongs to the UPF0176 family
SR187_RS01900	COG0357	Ribosomal RNA small subunit methyltransferase G
SR187_RS01905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SR187_RS01910	COG3331	DNA recombination
SR187_RS01915	COG4474	Belongs to the UPF0398 family
SR187_RS01920	COG3599	regulation of cell shape
SR187_RS01930	COG0116	Belongs to the methyltransferase superfamily
SR187_RS01945	COG1854	S-ribosylhomocysteine lyase activity
SR187_RS01950	COG1418	mRNA catabolic process
SR187_RS01960	COG1758	RNA polymerase activity
SR187_RS01965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SR187_RS01970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SR187_RS01975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SR187_RS01975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SR187_RS01980	COG0631	protein serine/threonine phosphatase activity
SR187_RS01985	COG0515	serine threonine protein kinase
SR187_RS01985	COG2815	serine threonine protein kinase
SR187_RS01995	COG4585	Histidine kinase
SR187_RS02010	COG1098	S1 RNA binding domain
SR187_RS02020	COG2801	Transposase and inactivated derivatives
SR187_RS02030	COG1739	Uncharacterized protein family UPF0029
SR187_RS02035	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SR187_RS02120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SR187_RS02125	COG2137	regulation of response to DNA damage stimulus
SR187_RS02130	COG3557	Belongs to the UPF0374 family
SR187_RS02140	COG2188	Transcriptional regulator
SR187_RS02145	COG2188	Transcriptional regulator
SR187_RS02155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR187_RS02165	COG3716	PTS system mannose fructose sorbose family IID component
SR187_RS02190	COG0346	lactoylglutathione lyase activity
SR187_RS02205	COG0346	lactoylglutathione lyase activity
SR187_RS02220	COG0525	valine-tRNA ligase activity
SR187_RS02280	COG1217	gtp-binding protein TYPA
SR187_RS02295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SR187_RS02310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SR187_RS02315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SR187_RS02320	COG1799	cell septum assembly
SR187_RS02335	COG3599	regulation of cell shape
SR187_RS02360	COG0542	response to heat
SR187_RS02365	COG4703	Protein of unknown function (DUF1797)
SR187_RS02370	COG0765	amino acid transport
SR187_RS02380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SR187_RS02385	COG2321	neutral zinc metallopeptidase
SR187_RS02390	COG1570	exodeoxyribonuclease VII activity
SR187_RS02395	COG1722	exodeoxyribonuclease VII activity
SR187_RS02405	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SR187_RS02410	COG1438	arginine binding
SR187_RS02415	COG0497	DNA recombination
SR187_RS02420	COG1307	EDD domain protein, DegV family
SR187_RS02455	COG3425	synthase
SR187_RS02460	COG0183	Belongs to the thiolase family
SR187_RS02475	COG0726	polysaccharide deacetylase
SR187_RS02480	COG0513	Belongs to the DEAD box helicase family
SR187_RS02505	COG1956	GAF domain-containing protein
SR187_RS02510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SR187_RS02520	COG1609	Transcriptional regulator
SR187_RS02535	COG1175	transmembrane transport
SR187_RS02540	COG3833	ABC-type maltose transport systems, permease component
SR187_RS02560	COG1363	Peptidase, m42
SR187_RS02565	COG2131	deaminase
SR187_RS02575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SR187_RS02580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SR187_RS02585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SR187_RS02590	COG0024	Methionine aminopeptidase
SR187_RS02610	COG4708	membrane
SR187_RS02615	COG2183	response to ionizing radiation
SR187_RS02620	COG3091	SprT-like family
SR187_RS02635	COG1482	cell wall glycoprotein biosynthetic process
SR187_RS02640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SR187_RS02645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SR187_RS02675	COG1174	glycine betaine transport
SR187_RS02695	COG2205	protein histidine kinase activity
SR187_RS02700	COG1136	(ABC) transporter
SR187_RS02705	COG0577	efflux transmembrane transporter activity
SR187_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
SR187_RS02740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SR187_RS02745	COG0494	nUDIX hydrolase
SR187_RS02755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SR187_RS02760	COG1737	Transcriptional regulator
SR187_RS02770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SR187_RS02775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SR187_RS02785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SR187_RS02795	COG2814	Major facilitator Superfamily
SR187_RS02800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SR187_RS02810	COG0557	exoribonuclease II activity
SR187_RS02815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SR187_RS02830	COG2217	Heavy metal translocating P-type atpase
SR187_RS02835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SR187_RS02840	COG1136	(ABC) transporter
SR187_RS02850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SR187_RS02850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SR187_RS02860	COG1832	CoA-binding protein
SR187_RS02870	COG0343	queuine tRNA-ribosyltransferase activity
SR187_RS02880	COG0006	proline dipeptidase activity
SR187_RS02885	COG1609	Transcriptional regulator
SR187_RS02890	COG0438	transferase activity, transferring glycosyl groups
SR187_RS02895	COG0438	transferase activity, transferring glycosyl groups
SR187_RS02905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SR187_RS02910	COG0765	amino acid transport
SR187_RS02915	COG0765	amino acid transport
SR187_RS02920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR187_RS02925	COG1126	abc transporter atp-binding protein
SR187_RS02930	COG0745	RESPONSE REGULATOR receiver
SR187_RS02940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SR187_RS02945	COG0768	penicillin binding
SR187_RS02955	COG1181	Belongs to the D-alanine--D-alanine ligase family
SR187_RS02970	COG1136	(ABC) transporter
SR187_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SR187_RS02985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SR187_RS03010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SR187_RS03015	COG0513	Belongs to the DEAD box helicase family
SR187_RS03035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SR187_RS03045	COG0626	cystathionine gamma-synthase activity
SR187_RS03050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SR187_RS03055	COG0366	Alpha amylase catalytic
SR187_RS03060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SR187_RS03075	COG0683	leucine binding
SR187_RS03080	COG0559	Belongs to the binding-protein-dependent transport system permease family
SR187_RS03105	COG0517	IMP dehydrogenase activity
SR187_RS03110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SR187_RS03115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SR187_RS03120	COG0470	DNA polymerase III
SR187_RS03125	COG4467	Involved in initiation control of chromosome replication
SR187_RS03135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SR187_RS03145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SR187_RS03150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SR187_RS03155	COG1393	Belongs to the ArsC family
SR187_RS03165	COG0708	Exodeoxyribonuclease III
SR187_RS03175	COG0531	amino acid
SR187_RS03195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SR187_RS03195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SR187_RS03220	COG4122	O-methyltransferase activity
SR187_RS03225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SR187_RS03235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SR187_RS03240	COG1476	TRANSCRIPTIONal
SR187_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
SR187_RS03285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SR187_RS03290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR187_RS03300	COG3716	PTS system mannose fructose sorbose family IID component
SR187_RS03310	COG5492	domain, Protein
SR187_RS03320	COG1609	Transcriptional regulator
SR187_RS03335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SR187_RS03340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SR187_RS03345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SR187_RS03350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR187_RS03370	COG1196	nuclear chromosome segregation
SR187_RS03375	COG0561	phosphatase activity
SR187_RS03380	COG0561	phosphatase activity
SR187_RS03385	COG0552	protein localization to endoplasmic reticulum
SR187_RS03415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SR187_RS03420	COG3689	TIGRFAM TIGR03943 family protein
SR187_RS03425	COG0701	Predicted permease
SR187_RS03435	COG1597	lipid kinase activity
SR187_RS03445	COG0356	it plays a direct role in the translocation of protons across the membrane
SR187_RS03450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SR187_RS03455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SR187_RS03460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SR187_RS03465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SR187_RS03470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SR187_RS03475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SR187_RS03485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SR187_RS03500	COG2211	Major facilitator Superfamily
SR187_RS03510	COG3250	beta-galactosidase activity
SR187_RS03520	COG0800	Aldolase
SR187_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
SR187_RS03555	COG0072	phenylalanine-tRNA ligase activity
SR187_RS03555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SR187_RS03565	COG1051	belongs to the nudix hydrolase family
SR187_RS03570	COG0302	gtp cyclohydrolase
SR187_RS03590	COG2610	gluconate transmembrane transporter activity
SR187_RS03595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SR187_RS03600	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SR187_RS03610	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SR187_RS03620	COG0813	purine-nucleoside phosphorylase activity
SR187_RS03625	COG0058	SHG alpha-glucan phosphorylase activity
SR187_RS03650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SR187_RS03675	COG1132	(ABC) transporter
SR187_RS03695	COG0647	UMP catabolic process
SR187_RS03705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SR187_RS03710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SR187_RS03715	COG1970	mechanosensitive ion channel activity
SR187_RS03720	COG0358	DNA primase activity
SR187_RS03725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SR187_RS03730	COG2151	metal-sulfur cluster biosynthetic enzyme
SR187_RS03735	COG1982	Orn Lys Arg decarboxylase major
SR187_RS03740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SR187_RS03770	COG2207	Transcriptional regulator
SR187_RS03780	COG1653	transport
SR187_RS03785	COG1175	transmembrane transport
SR187_RS03790	COG0395	ABC-type sugar transport system, permease component
SR187_RS03795	COG0366	Alpha amylase catalytic
SR187_RS03820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SR187_RS03830	COG1131	(ABC) transporter
SR187_RS03835	COG2188	Transcriptional regulator
SR187_RS03845	COG0205	6-phosphofructokinase activity
SR187_RS03850	COG0469	pyruvate kinase activity
SR187_RS03860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SR187_RS03865	COG0657	acetylesterase activity
SR187_RS03865	COG2755	lipolytic protein G-D-S-L family
SR187_RS03875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SR187_RS03880	COG0765	amino acid transport
SR187_RS03885	COG1126	abc transporter atp-binding protein
SR187_RS03890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR187_RS03895	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SR187_RS03930	COG4372	Transposase
SR187_RS03940	COG2195	Cleaves the N-terminal amino acid of tripeptides
SR187_RS03945	COG0561	phosphatase activity
SR187_RS03980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SR187_RS03985	COG0196	riboflavin kinase activity
SR187_RS03990	COG1393	Belongs to the ArsC family
SR187_RS03995	COG4476	Belongs to the UPF0223 family
SR187_RS04000	COG0483	inositol monophosphate 1-phosphatase activity
SR187_RS04005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SR187_RS04005	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SR187_RS04015	COG0573	inorganic phosphate transmembrane transporter activity
SR187_RS04020	COG0581	inorganic phosphate transmembrane transporter activity
SR187_RS04025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SR187_RS04030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SR187_RS04035	COG0704	Plays a role in the regulation of phosphate uptake
SR187_RS04040	COG0745	RESPONSE REGULATOR receiver
SR187_RS04045	COG5002	protein histidine kinase activity
SR187_RS04060	COG0268	Binds directly to 16S ribosomal RNA
SR187_RS04065	COG1072	(Pantothenic acid kinase))
SR187_RS04070	COG2813	Specifically methylates the guanine in position
SR187_RS04075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SR187_RS04085	COG0295	cytidine deaminase activity
SR187_RS04090	COG1744	ABC transporter substrate-binding protein PnrA-like
SR187_RS04100	COG4603	Belongs to the binding-protein-dependent transport system permease family
SR187_RS04105	COG1079	Belongs to the binding-protein-dependent transport system permease family
SR187_RS04110	COG0039	L-malate dehydrogenase activity
SR187_RS04115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SR187_RS04120	COG3764	Sortase (surface protein transpeptidase)
SR187_RS04130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SR187_RS04145	COG1104	cysteine desulfurase activity
SR187_RS04155	COG4116	CYTH
SR187_RS04160	COG2357	RelA SpoT domain protein
SR187_RS04165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SR187_RS04170	COG0564	pseudouridine synthase activity
SR187_RS04175	COG0280	phosphate acetyltransferase
SR187_RS04185	COG1132	(ABC) transporter
SR187_RS04200	COG0488	(ABC) transporter
SR187_RS04210	COG1126	abc transporter atp-binding protein
SR187_RS04235	COG0789	Transcriptional regulator
SR187_RS04235	COG4978	Transcriptional regulator
SR187_RS04255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SR187_RS04260	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SR187_RS04270	COG1882	Formate acetyltransferase
SR187_RS04275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR187_RS04320	COG1454	alcohol dehydrogenase
SR187_RS04320	COG1012	belongs to the aldehyde dehydrogenase family
SR187_RS04325	COG4869	propanediol catabolic process
SR187_RS04350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR187_RS04360	COG0297	glycogen (starch) synthase activity
SR187_RS04370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SR187_RS04385	COG0543	2 iron, 2 sulfur cluster binding
SR187_RS04390	COG0167	dihydroorotate dehydrogenase activity
SR187_RS04395	COG0284	orotidine-5'-phosphate decarboxylase activity
SR187_RS04405	COG0463	Glycosyl transferase, family 2
SR187_RS04410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SR187_RS04420	COG0737	Belongs to the 5'-nucleotidase family
SR187_RS04440	COG3290	protein histidine kinase activity
SR187_RS04470	COG1136	(ABC) transporter
SR187_RS04470	COG0577	efflux transmembrane transporter activity
SR187_RS04485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SR187_RS04490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SR187_RS04500	COG1272	protein, Hemolysin III
SR187_RS04510	COG0110	maltose O-acetyltransferase activity
SR187_RS04515	COG0758	DNA mediated transformation
SR187_RS04520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SR187_RS04525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SR187_RS04530	COG0222	ribosome binding
SR187_RS04545	COG0270	DNA (cytosine-5-)-methyltransferase activity
SR187_RS04765	COG3843	relaxase mobilization nuclease domain protein
SR187_RS04785	COG1131	(ABC) transporter
SR187_RS04805	COG4974	Belongs to the 'phage' integrase family
SR187_RS04810	COG1349	DNA-binding transcription factor activity
SR187_RS04815	COG0698	ribose 5-phosphate isomerase
SR187_RS04820	COG0698	ribose 5-phosphate isomerase
SR187_RS04825	COG1105	Belongs to the carbohydrate kinase PfkB family
SR187_RS04830	COG3684	Belongs to the aldolase LacD family
SR187_RS04835	COG3711	transcriptional antiterminator
SR187_RS04845	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR187_RS04845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR187_RS04850	COG2723	6-phospho-beta-galactosidase activity
SR187_RS04855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SR187_RS04890	COG1136	(ABC) transporter
SR187_RS04900	COG0745	RESPONSE REGULATOR receiver
SR187_RS04905	COG5002	protein histidine kinase activity
SR187_RS04915	COG4974	Belongs to the 'phage' integrase family
SR187_RS04950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SR187_RS04955	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SR187_RS04960	COG2188	Transcriptional regulator
SR187_RS04965	COG0519	Catalyzes the synthesis of GMP from XMP
SR187_RS04965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SR187_RS04975	COG0789	Transcriptional regulator
SR187_RS04985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SR187_RS05000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR187_RS05010	COG4221	oxidoreductase activity
SR187_RS05015	COG0741	lytic transglycosylase activity
SR187_RS05025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SR187_RS05035	COG0009	L-threonylcarbamoyladenylate synthase
SR187_RS05040	COG2890	protein-(glutamine-N5) methyltransferase activity
SR187_RS05045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SR187_RS05065	COG1942	4-Oxalocrotonate Tautomerase
SR187_RS05070	COG0481	GTPase activity
SR187_RS05080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SR187_RS05090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SR187_RS05095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SR187_RS05110	COG1940	carbohydrate kinase activity
SR187_RS05120	COG0488	(ABC) transporter
SR187_RS05125	COG0617	tRNA 3'-terminal CCA addition
SR187_RS05130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SR187_RS05135	COG1307	EDD domain protein, DegV family
SR187_RS05145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR187_RS05145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR187_RS05145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR187_RS05150	COG1105	Belongs to the carbohydrate kinase PfkB family
SR187_RS05155	COG1349	DNA-binding transcription factor activity
SR187_RS05160	COG0336	Belongs to the RNA methyltransferase TrmD family
SR187_RS05165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SR187_RS05170	COG0534	Mate efflux family protein
SR187_RS05185	COG1136	(ABC) transporter
SR187_RS05190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SR187_RS05195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SR187_RS05205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SR187_RS05210	COG1177	transmembrane transport
SR187_RS05215	COG1176	ABC-type spermidine putrescine transport system, permease component I
SR187_RS05220	COG3842	ATPase activity
SR187_RS05225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SR187_RS05230	COG0083	homoserine kinase activity
SR187_RS05240	COG0726	polysaccharide deacetylase
SR187_RS05245	COG1132	(ABC) transporter
SR187_RS05255	COG1837	Belongs to the UPF0109 family
SR187_RS05260	COG0228	four-way junction DNA binding
SR187_RS05265	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SR187_RS05270	COG2521	methyltransferase
SR187_RS05270	COG2136	Putative SAM-dependent methyltransferase
SR187_RS05280	COG0505	Belongs to the CarA family
SR187_RS05285	COG0540	Belongs to the ATCase OTCase family
SR187_RS05290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SR187_RS05300	COG2824	Alkylphosphonate utilization operon protein PhnA
SR187_RS05305	COG0564	pseudouridine synthase activity
SR187_RS05325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SR187_RS05330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SR187_RS05335	COG1114	Component of the transport system for branched-chain amino acids
SR187_RS05340	COG0301	tRNA thio-modification
SR187_RS05345	COG1104	cysteine desulfurase activity
SR187_RS05360	COG0539	negative regulation of cytoplasmic translation
SR187_RS05380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SR187_RS05385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SR187_RS05395	COG0187	DNA topoisomerase II activity
SR187_RS05405	COG1074	ATP-dependent DNA helicase activity
SR187_RS05410	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SR187_RS05430	COG0322	excinuclease ABC activity
SR187_RS05435	COG1131	(ABC) transporter
SR187_RS05450	COG1011	Hydrolase
SR187_RS05460	COG0210	DNA helicase
SR187_RS05475	COG1164	Oligoendopeptidase f
SR187_RS05480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SR187_RS05485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SR187_RS05490	COG1523	belongs to the glycosyl hydrolase 13 family
SR187_RS05515	COG1882	Formate acetyltransferase
SR187_RS05520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR187_RS05525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR187_RS05530	COG1447	Phosphotransferase system cellobiose-specific component IIA
SR187_RS05540	COG1349	DNA-binding transcription factor activity
SR187_RS05545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR187_RS05555	COG1247	-acetyltransferase
SR187_RS05565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SR187_RS05570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SR187_RS05580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SR187_RS05585	COG4684	Psort location CytoplasmicMembrane, score
SR187_RS05615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SR187_RS05645	COG3237	CsbD-like
SR187_RS05665	COG2261	transglycosylase associated protein
SR187_RS05675	COG2188	Transcriptional regulator
SR187_RS05690	COG4555	ABC transporter
SR187_RS05715	COG2197	response regulator
SR187_RS05740	COG1132	(ABC) transporter
SR187_RS05905	COG0464	growth
SR187_RS05925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SR187_RS05935	COG0077	Prephenate dehydratase
SR187_RS05940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SR187_RS05950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SR187_RS05955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SR187_RS05960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SR187_RS05965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SR187_RS05965	COG1116	anion transmembrane transporter activity
SR187_RS05970	COG4120	Belongs to the binding-protein-dependent transport system permease family
SR187_RS05985	COG3679	Belongs to the UPF0342 family
SR187_RS05990	COG0287	Prephenate dehydrogenase
SR187_RS05995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SR187_RS06000	COG0710	3-dehydroquinate dehydratase activity
SR187_RS06005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SR187_RS06010	COG1368	sulfuric ester hydrolase activity
SR187_RS06050	COG4509	Sortase family
SR187_RS06065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SR187_RS06075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SR187_RS06120	COG1216	Glycosyl transferase, family 2
SR187_RS06120	COG0463	Glycosyl transferase, family 2
SR187_RS06155	COG0463	Glycosyl transferase, family 2
SR187_RS06170	COG1705	Flagellar rod assembly protein muramidase FlgJ
SR187_RS06175	COG1091	dTDP-4-dehydrorhamnose reductase activity
SR187_RS06180	COG1088	dTDP-glucose 4,6-dehydratase activity
SR187_RS06195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SR187_RS06200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SR187_RS06205	COG2384	SAM-dependent methyltransferase
SR187_RS06215	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SR187_RS06220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SR187_RS06225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SR187_RS06225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SR187_RS06230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SR187_RS06240	COG0300	oxidoreductase activity
SR187_RS06245	COG1234	tRNA 3'-trailer cleavage
SR187_RS06255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SR187_RS06260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SR187_RS06270	COG2807	transmembrane transport
SR187_RS06275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SR187_RS06280	COG2755	lipolytic protein G-D-S-L family
SR187_RS06280	COG1083	cytidylyl-transferase
SR187_RS06295	COG2089	acid synthase
SR187_RS06310	COG1518	maintenance of DNA repeat elements
SR187_RS06320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SR187_RS06325	COG1704	LemA family
SR187_RS06340	COG2226	methyltransferase
SR187_RS06345	COG0488	(ABC) transporter
SR187_RS06350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SR187_RS06360	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SR187_RS06365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SR187_RS06370	COG3442	glutamine amidotransferase
SR187_RS06380	COG2226	methyltransferase
SR187_RS06390	COG0488	(ABC) transporter
SR187_RS06415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SR187_RS06430	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SR187_RS06435	COG3527	Alpha-acetolactate decarboxylase
SR187_RS06445	COG0628	permease
SR187_RS06450	COG2706	6-phosphogluconolactonase activity
SR187_RS06460	COG1011	Hydrolase
SR187_RS06490	COG0560	Phosphoserine phosphatase
SR187_RS06495	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SR187_RS06500	COG0187	DNA topoisomerase II activity
SR187_RS06505	COG0693	protein deglycase activity
SR187_RS06510	COG0772	Belongs to the SEDS family
SR187_RS06525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SR187_RS06530	COG0716	FMN binding
SR187_RS06540	COG0287	Prephenate dehydrogenase
SR187_RS06540	COG1605	Chorismate mutase
SR187_RS06545	COG0038	chloride channel
SR187_RS06570	COG0335	large ribosomal subunit rRNA binding
SR187_RS06575	COG0737	Belongs to the 5'-nucleotidase family
SR187_RS06585	COG3620	sequence-specific DNA binding
SR187_RS06595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SR187_RS06600	COG1466	dna polymerase III delta subunit
SR187_RS06610	COG2333	competence protein COMEC
SR187_RS06610	COG0658	competence protein
SR187_RS06615	COG1596	polysaccharide export
SR187_RS06615	COG1555	photosystem II stabilization
SR187_RS06620	COG0204	Acyl-transferase
SR187_RS06625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SR187_RS06630	COG1120	ATPase activity
SR187_RS06640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR187_RS06645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR187_RS06650	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SR187_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SR187_RS06660	COG1696	Membrane protein involved in D-alanine export
SR187_RS06675	COG0363	glucosamine-6-phosphate deaminase activity
SR187_RS06685	COG1438	arginine binding
SR187_RS06690	COG2273	Hydrolase Family 16
SR187_RS06695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SR187_RS06700	COG1288	antiporter activity
SR187_RS06710	COG0549	Belongs to the carbamate kinase family
SR187_RS06715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SR187_RS06720	COG0454	-acetyltransferase
SR187_RS06735	COG1481	regulation of sporulation
SR187_RS06740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SR187_RS06745	COG1660	Displays ATPase and GTPase activities
SR187_RS06750	COG0251	oxidation-reduction process
SR187_RS06760	COG0436	Aminotransferase
SR187_RS06785	COG0562	UDP-galactopyranose mutase
SR187_RS06790	COG4750	Nucleotidyl transferase
SR187_RS06800	COG1213	nucleotidyl transferase
SR187_RS06805	COG3475	LICD family
SR187_RS06835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SR187_RS06845	COG3955	Domain of unknown function (DUF1919)
SR187_RS06865	COG4464	protein tyrosine phosphatase activity
SR187_RS06875	COG3944	biosynthesis protein
SR187_RS06885	COG3022	response to hydroperoxide
SR187_RS06890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SR187_RS06895	COG1307	EDD domain protein, DegV family
SR187_RS06905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SR187_RS06925	COG1702	phosphate starvation-inducible protein PhoH
SR187_RS06930	COG4479	Belongs to the UPF0346 family
SR187_RS06935	COG2996	Protein conserved in bacteria
SR187_RS06940	COG0233	cytoplasmic translational termination
SR187_RS06945	COG0528	UMP kinase activity
SR187_RS06950	COG2244	polysaccharide biosynthetic process
SR187_RS07000	COG0346	lactoylglutathione lyase activity
SR187_RS07005	COG0697	spore germination
SR187_RS07005	COG1674	ftsk spoiiie
SR187_RS07010	COG1621	beta-fructofuranosidase activity
SR187_RS07015	COG1653	transport
SR187_RS07020	COG0395	ABC-type sugar transport system, permease component
SR187_RS07025	COG4209	transmembrane transport
SR187_RS07030	COG1609	Transcriptional regulator
SR187_RS07050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SR187_RS07065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SR187_RS07080	COG0395	ABC-type sugar transport system, permease component
SR187_RS07085	COG1175	transmembrane transport
SR187_RS07100	COG1011	Hydrolase
SR187_RS07110	COG1132	(ABC) transporter
SR187_RS07115	COG1132	(ABC) transporter
SR187_RS07125	COG2177	Part of the ABC transporter FtsEX involved in
SR187_RS07130	COG2884	Cell division ATP-binding protein ftsE
SR187_RS07165	COG1078	dGTPase activity
SR187_RS07175	COG0149	triose-phosphate isomerase activity
SR187_RS07200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SR187_RS07220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SR187_RS07225	COG0772	Belongs to the SEDS family
SR187_RS07235	COG3859	Proton-coupled thiamine transporter YuaJ
SR187_RS07245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SR187_RS07250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SR187_RS07265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SR187_RS07270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SR187_RS07275	COG1268	BioY protein
SR187_RS07280	COG4443	Transcriptional Coactivator p15 (PC4)
SR187_RS07290	COG0826	peptidase U32
SR187_RS07305	COG1227	inorganic diphosphatase activity
SR187_RS07320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR187_RS07325	COG1253	flavin adenine dinucleotide binding
SR187_RS07330	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SR187_RS07340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SR187_RS07345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SR187_RS07360	COG4470	Protein conserved in bacteria
SR187_RS07365	COG3480	Lon protease (S16) C-terminal proteolytic domain
SR187_RS07370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SR187_RS07375	COG0742	ribosomal rna small subunit methyltransferase
SR187_RS07385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SR187_RS07390	COG4483	Protein conserved in bacteria
SR187_RS07395	COG2197	response regulator
SR187_RS07405	COG0842	Transport permease protein
SR187_RS07410	COG1131	(ABC) transporter
SR187_RS07420	COG2801	Transposase and inactivated derivatives
SR187_RS07445	COG2755	lipolytic protein G-D-S-L family
SR187_RS07445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SR187_RS07455	COG0671	phosphoesterase, PA-phosphatase related
SR187_RS07460	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SR187_RS07470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SR187_RS07475	COG1187	pseudouridine synthase activity
SR187_RS07480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SR187_RS07485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SR187_RS07490	COG0582	viral genome integration into host DNA
SR187_RS07510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SR187_RS07515	COG3763	UPF0154 protein
SR187_RS07525	COG3579	cysteine-type endopeptidase activity
SR187_RS07530	COG0670	Belongs to the BI1 family
SR187_RS07535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SR187_RS07540	COG1254	Belongs to the acylphosphatase family
SR187_RS07550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SR187_RS07555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SR187_RS07565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SR187_RS07575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SR187_RS07595	COG2801	Transposase and inactivated derivatives
SR187_RS07600	COG1160	GTP binding
SR187_RS07610	COG1484	DNA-dependent DNA replication
SR187_RS07620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SR187_RS07625	COG0628	permease
SR187_RS07630	COG0745	RESPONSE REGULATOR receiver
SR187_RS07635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SR187_RS07645	COG0492	ferredoxin-NADP+ reductase activity
SR187_RS07655	COG0513	Belongs to the DEAD box helicase family
SR187_RS07665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SR187_RS07670	COG0768	penicillin binding
SR187_RS07680	COG0275	rRNA processing
SR187_RS07725	COG4939	FMN-binding domain protein
SR187_RS07730	COG0142	geranyltranstransferase activity
SR187_RS07735	COG1252	NADH dehydrogenase
SR187_RS07745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SR187_RS07750	COG0569	domain protein
SR187_RS07755	COG0534	Mate efflux family protein
SR187_RS07770	COG0751	glycine-tRNA ligase activity
SR187_RS07780	COG1755	Isoprenylcysteine carboxyl methyltransferase
SR187_RS07790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SR187_RS07795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SR187_RS07800	COG1464	Belongs to the NlpA lipoprotein family
SR187_RS07805	COG2252	PERMEase
SR187_RS07810	COG0561	phosphatase activity
SR187_RS07825	COG3715	PTS system
SR187_RS07830	COG3716	PTS system mannose fructose sorbose family IID component
SR187_RS07845	COG1983	PspC domain protein
SR187_RS07855	COG0825	malonyl-CoA metabolic process
SR187_RS07865	COG0439	Biotin carboxylase
SR187_RS07880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SR187_RS07885	COG1028	Short-chain dehydrogenase reductase Sdr
SR187_RS07890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SR187_RS07905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SR187_RS07915	COG1024	Enoyl-CoA hydratase
SR187_RS07920	COG0527	aspartate kinase activity
SR187_RS07925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SR187_RS07930	COG0736	holo-[acyl-carrier-protein] synthase activity
SR187_RS07935	COG0653	protein targeting
SR187_RS07940	COG1940	carbohydrate kinase activity
SR187_RS07945	COG2190	(PTS) system
SR187_RS07945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR187_RS07945	COG1263	PTS System
SR187_RS07950	COG1621	beta-fructofuranosidase activity
SR187_RS07955	COG1609	Transcriptional regulator
SR187_RS07960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SR187_RS07975	COG0006	proline dipeptidase activity
SR187_RS08000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SR187_RS08025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SR187_RS08040	COG0095	Lipoate-protein ligase
SR187_RS08045	COG2723	6-phospho-beta-galactosidase activity
SR187_RS08055	COG2723	6-phospho-beta-galactosidase activity
SR187_RS08060	COG0346	lactoylglutathione lyase activity
SR187_RS08065	COG2723	6-phospho-beta-galactosidase activity
SR187_RS08080	COG2272	Belongs to the type-B carboxylesterase lipase family
SR187_RS08090	COG3711	transcriptional antiterminator
SR187_RS08095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR187_RS08105	COG1447	Phosphotransferase system cellobiose-specific component IIA
SR187_RS08110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR187_RS08110	COG3711	transcriptional antiterminator
SR187_RS08125	COG2723	6-phospho-beta-galactosidase activity
SR187_RS08140	COG0508	dehydrogenase complex catalyzes the overall conversion of
SR187_RS08145	COG0508	dehydrogenase complex catalyzes the overall conversion of
SR187_RS08145	COG0022	dehydrogenase e1 component
SR187_RS08150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SR187_RS08155	COG2860	membrane
SR187_RS08160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SR187_RS08165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SR187_RS08175	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SR187_RS08180	COG0195	Participates in both transcription termination and antitermination
SR187_RS08190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SR187_RS08200	COG4473	ABC transporter
SR187_RS08205	COG1131	(ABC) transporter
SR187_RS08210	COG0537	adenosine 5'-monophosphoramidase activity
SR187_RS08220	COG1316	TRANSCRIPTIONal
SR187_RS08230	COG0802	atpase or kinase
SR187_RS08245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SR187_RS08250	COG0601	transmembrane transport
SR187_RS08255	COG4608	Belongs to the ABC transporter superfamily
SR187_RS08270	COG1686	Belongs to the peptidase S11 family
SR187_RS08285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SR187_RS08290	COG0454	-acetyltransferase
SR187_RS08295	COG0719	Fe-S assembly protein
SR187_RS08305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SR187_RS08310	COG4862	establishment of competence for transformation
SR187_RS08315	COG1968	undecaprenyl-diphosphatase activity
SR187_RS08320	COG0765	amino acid transport
SR187_RS08325	COG1126	abc transporter atp-binding protein
SR187_RS08340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SR187_RS08345	COG0440	acetolactate synthase activity
SR187_RS08350	COG0028	Belongs to the TPP enzyme family
SR187_RS08355	COG0129	dihydroxy-acid dehydratase activity
SR187_RS08370	COG2151	metal-sulfur cluster biosynthetic enzyme
SR187_RS08450	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SR187_RS08485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SR187_RS08500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SR187_RS08520	COG3842	ATPase activity
SR187_RS08530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SR187_RS08550	COG1045	serine acetyltransferase
SR187_RS08555	COG1185	polyribonucleotide nucleotidyltransferase activity
SR187_RS08570	COG1132	(ABC) transporter
SR187_RS08585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SR187_RS08595	COG1187	pseudouridine synthase activity
SR187_RS08610	COG0242	peptide deformylase activity
SR187_RS08620	COG2309	aminopeptidase activity
SR187_RS08630	COG2176	DNA-directed DNA polymerase activity
SR187_RS08645	COG2376	Dihydroxyacetone kinase
SR187_RS08655	COG2376	Dihydroxyacetone kinase
SR187_RS08660	COG1461	Dihydroxyacetone kinase
SR187_RS08665	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SR187_RS08670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SR187_RS08675	COG0442	prolyl-tRNA aminoacylation
SR187_RS08685	COG4589	Belongs to the CDS family
SR187_RS08690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SR187_RS08695	COG1862	Preprotein translocase
SR187_RS08705	COG2918	glutathione biosynthetic process
SR187_RS08705	COG1181	Belongs to the D-alanine--D-alanine ligase family
SR187_RS08715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SR187_RS08720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SR187_RS08730	COG0542	response to heat
SR187_RS08735	COG4463	regulation of RNA biosynthetic process
SR187_RS08750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SR187_RS08755	COG0052	Belongs to the universal ribosomal protein uS2 family
SR187_RS08775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SR187_RS08780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SR187_RS08785	COG0492	ferredoxin-NADP+ reductase activity
SR187_RS08790	COG0564	pseudouridine synthase activity
SR187_RS08915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SR187_RS08935	COG1564	THIamine pyrophosphokinase
SR187_RS08945	COG1162	GTPase activity
SR187_RS08995	COG0084	hydrolase, TatD family'
SR187_RS09005	COG1847	R3H domain protein
SR187_RS09015	COG0594	ribonuclease P activity
SR187_RS09025	COG1827	regulation of RNA biosynthetic process
SR187_RS09035	COG1136	(ABC) transporter
SR187_RS09080	COG0756	dUTP diphosphatase activity
SR187_RS09100	COG1132	(ABC) transporter
SR187_RS09105	COG1132	(ABC) transporter
SR187_RS09110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SR187_RS09115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SR187_RS09120	COG0705	Rhomboid family
SR187_RS09125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SR187_RS09130	COG1473	amidohydrolase
SR187_RS09145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SR187_RS09150	COG0166	Belongs to the GPI family
SR187_RS09155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SR187_RS09180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SR187_RS09200	COG3623	hexulose-6-phosphate isomerase
SR187_RS09225	COG1523	belongs to the glycosyl hydrolase 13 family
SR187_RS09235	COG0463	Glycosyl transferase, family 2
SR187_RS09245	COG1609	Transcriptional regulator
SR187_RS09250	COG1126	abc transporter atp-binding protein
SR187_RS09255	COG0765	amino acid transport
SR187_RS09260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR187_RS09265	COG3942	CHAP domain
SR187_RS09270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR187_RS09280	COG1447	Phosphotransferase system cellobiose-specific component IIA
SR187_RS09290	COG3711	transcriptional antiterminator
SR187_RS09290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR187_RS09300	COG2723	6-phospho-beta-galactosidase activity
SR187_RS09320	COG3590	peptidase
SR187_RS09325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SR187_RS09330	COG1321	iron dependent repressor
SR187_RS09330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SR187_RS09335	COG1121	(ABC) transporter
SR187_RS09340	COG0803	Belongs to the bacterial solute-binding protein 9 family
SR187_RS09350	COG1490	D-aminoacyl-tRNA deacylase activity
SR187_RS09360	COG0737	Belongs to the 5'-nucleotidase family
SR187_RS09365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SR187_RS09395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SR187_RS09420	COG1132	(ABC) transporter
SR187_RS09460	COG1396	sequence-specific DNA binding
SR187_RS09475	COG0673	inositol 2-dehydrogenase activity
SR187_RS09485	COG1328	CTP reductase activity
SR187_RS09490	COG1131	(ABC) transporter
SR187_RS09520	COG1438	arginine binding
SR187_RS09525	COG0018	arginyl-trna synthetase
SR187_RS09530	COG1388	LysM domain
SR187_RS09530	COG3942	CHAP domain
SR187_RS09545	COG1640	4-alpha-glucanotransferase
SR187_RS09550	COG2182	Extracellular solute-binding protein
SR187_RS09555	COG1175	transmembrane transport
SR187_RS09560	COG3833	ABC-type maltose transport systems, permease component
SR187_RS09565	COG5521	maltodextrose utilization protein MalA
SR187_RS09570	COG1609	Transcriptional regulator
SR187_RS09575	COG1523	belongs to the glycosyl hydrolase 13 family
SR187_RS09580	COG1780	Probably involved in ribonucleotide reductase function
SR187_RS09585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SR187_RS09590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SR187_RS09595	COG2153	protein acetylation
SR187_RS09600	COG4989	oxidoreductase activity
SR187_RS09605	COG1216	Glycosyl transferase, family 2
SR187_RS09610	COG1472	Belongs to the glycosyl hydrolase 3 family
SR187_RS09645	COG1132	(ABC) transporter
SR187_RS09660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SR187_RS09670	COG0305	Participates in initiation and elongation during chromosome replication
SR187_RS09675	COG0359	binds to the 23S rRNA
SR187_RS09685	COG0445	tRNA wobble uridine modification
SR187_RS09690	COG0494	nUDIX hydrolase
SR187_RS09695	COG1733	regulation of RNA biosynthetic process
SR187_RS09705	COG0482	sulfurtransferase activity
SR187_RS09710	COG1760	l-serine dehydratase
SR187_RS09715	COG1760	l-serine dehydratase
SR187_RS09725	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SR187_RS09730	COG1122	ATPase activity
SR187_RS09735	COG1122	ATPase activity
SR187_RS09740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SR187_RS09745	COG1426	Protein conserved in bacteria
SR187_RS09750	COG0612	Peptidase, M16
SR187_RS09755	COG0612	Peptidase, M16
SR187_RS09765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SR187_RS09775	COG0517	IMP dehydrogenase activity
SR187_RS09775	COG0516	GMP reductase activity
SR187_RS09785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SR187_RS09790	COG0488	(ABC) transporter
SR187_RS09820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SR187_RS09825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SR187_RS09830	COG1475	DNA binding