locus-tag	class	description
NX99_RS00005	COG0488	(ABC) transporter
NX99_RS00025	COG3064	Membrane
NX99_RS00035	COG0420	3'-5' exonuclease activity
NX99_RS00040	COG0419	ATPase involved in DNA repair
NX99_RS00045	COG1442	glycosyl transferase family 8
NX99_RS00045	COG1216	Glycosyl transferase, family 2
NX99_RS00070	COG0653	protein targeting
NX99_RS00080	COG0438	transferase activity, transferring glycosyl groups
NX99_RS00120	COG5263	repeat protein
NX99_RS00120	COG0366	Alpha amylase catalytic
NX99_RS00130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NX99_RS00135	COG0110	maltose O-acetyltransferase activity
NX99_RS00145	COG0477	Major facilitator Superfamily
NX99_RS00200	COG5263	repeat protein
NX99_RS00200	COG0366	Alpha amylase catalytic
NX99_RS00215	COG0366	Alpha amylase catalytic
NX99_RS00215	COG5263	repeat protein
NX99_RS00215	COG0366	Alpha amylase catalytic
NX99_RS00215	COG5263	repeat protein
NX99_RS00225	COG0366	Alpha amylase catalytic
NX99_RS00225	COG5263	repeat protein
NX99_RS00230	COG0366	Alpha amylase catalytic
NX99_RS00230	COG5263	repeat protein
NX99_RS00240	COG5263	repeat protein
NX99_RS00240	COG0366	Alpha amylase catalytic
NX99_RS00250	COG0640	Transcriptional regulator
NX99_RS00270	COG3590	peptidase
NX99_RS00295	COG2376	Dihydroxyacetone kinase
NX99_RS00300	COG1461	Dihydroxyacetone kinase
NX99_RS00305	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NX99_RS00335	COG1136	(ABC) transporter
NX99_RS00340	COG0577	efflux transmembrane transporter activity
NX99_RS00345	COG0745	RESPONSE REGULATOR receiver
NX99_RS00350	COG5002	protein histidine kinase activity
NX99_RS00355	COG0366	Alpha amylase catalytic
NX99_RS00360	COG2207	Transcriptional regulator
NX99_RS00365	COG3345	alpha-galactosidase
NX99_RS00370	COG1653	transport
NX99_RS00375	COG1175	transmembrane transport
NX99_RS00380	COG0395	ABC-type sugar transport system, permease component
NX99_RS00385	COG3842	ATPase activity
NX99_RS00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NX99_RS00395	COG0366	Alpha amylase catalytic
NX99_RS00400	COG0366	Alpha amylase catalytic
NX99_RS00405	COG1609	Transcriptional regulator
NX99_RS00420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NX99_RS00425	COG2017	converts alpha-aldose to the beta-anomer
NX99_RS00430	COG2190	(PTS) system
NX99_RS00430	COG2211	Major facilitator Superfamily
NX99_RS00435	COG3250	beta-galactosidase activity
NX99_RS00445	COG0656	L-ascorbic acid biosynthetic process
NX99_RS00465	COG0778	Nitroreductase
NX99_RS00470	COG0745	RESPONSE REGULATOR receiver
NX99_RS00475	COG2205	protein histidine kinase activity
NX99_RS00495	COG1131	(ABC) transporter
NX99_RS00510	COG1959	2 iron, 2 sulfur cluster binding
NX99_RS00515	COG2514	catechol 2,3-dioxygenase activity
NX99_RS00525	COG4989	oxidoreductase activity
NX99_RS00550	COG0386	Belongs to the glutathione peroxidase family
NX99_RS00555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NX99_RS00560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS00565	COG0765	amino acid transport
NX99_RS00570	COG0765	amino acid transport
NX99_RS00575	COG1126	abc transporter atp-binding protein
NX99_RS00595	COG0531	amino acid
NX99_RS00610	COG3237	CsbD-like
NX99_RS00625	COG1482	cell wall glycoprotein biosynthetic process
NX99_RS00630	COG1114	Component of the transport system for branched-chain amino acids
NX99_RS00655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NX99_RS00655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NX99_RS00665	COG0534	Mate efflux family protein
NX99_RS00680	COG2233	PERMEase
NX99_RS00690	COG0745	RESPONSE REGULATOR receiver
NX99_RS00700	COG1136	(ABC) transporter
NX99_RS00705	COG0577	efflux transmembrane transporter activity
NX99_RS00725	COG1131	(ABC) transporter
NX99_RS00740	COG0385	Bile acid
NX99_RS00755	COG1131	(ABC) transporter
NX99_RS00765	COG4585	Histidine kinase
NX99_RS00770	COG2197	response regulator
NX99_RS00830	COG0697	spore germination
NX99_RS00835	COG5492	domain, Protein
NX99_RS00835	COG3583	domain protein
NX99_RS00835	COG1621	beta-fructofuranosidase activity
NX99_RS00840	COG1760	l-serine dehydratase
NX99_RS00845	COG1760	l-serine dehydratase
NX99_RS00850	COG1011	Hydrolase
NX99_RS00860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX99_RS00870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NX99_RS00880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NX99_RS00895	COG1196	nuclear chromosome segregation
NX99_RS00935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NX99_RS00935	COG1328	CTP reductase activity
NX99_RS00940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NX99_RS00965	COG0488	(ABC) transporter
NX99_RS00985	COG3764	Sortase (surface protein transpeptidase)
NX99_RS00990	COG0346	lactoylglutathione lyase activity
NX99_RS01015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NX99_RS01020	COG0625	glutathione transferase activity
NX99_RS01025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NX99_RS01030	COG1435	thymidine kinase activity
NX99_RS01040	COG2890	protein-(glutamine-N5) methyltransferase activity
NX99_RS01045	COG0009	L-threonylcarbamoyladenylate synthase
NX99_RS01070	COG1132	(ABC) transporter
NX99_RS01085	COG1696	Membrane protein involved in D-alanine export
NX99_RS01095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NX99_RS01100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NX99_RS01105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NX99_RS01125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NX99_RS01130	COG4684	Psort location CytoplasmicMembrane, score
NX99_RS01135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NX99_RS01150	COG0745	RESPONSE REGULATOR receiver
NX99_RS01155	COG5002	protein histidine kinase activity
NX99_RS01170	COG2813	Specifically methylates the guanine in position
NX99_RS01175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NX99_RS01180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NX99_RS01185	COG0295	cytidine deaminase activity
NX99_RS01190	COG1744	ABC transporter substrate-binding protein PnrA-like
NX99_RS01195	COG3845	ABC transporter
NX99_RS01200	COG4603	Belongs to the binding-protein-dependent transport system permease family
NX99_RS01205	COG1079	Belongs to the binding-protein-dependent transport system permease family
NX99_RS01215	COG1199	ATP-dependent helicase activity
NX99_RS01215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NX99_RS01225	COG0436	Aminotransferase
NX99_RS01230	COG0017	Asparaginyl-tRNA synthetase
NX99_RS01240	COG0251	oxidation-reduction process
NX99_RS01250	COG0720	synthase
NX99_RS01300	COG0803	Belongs to the bacterial solute-binding protein 9 family
NX99_RS01300	COG3443	Belongs to the bacterial solute-binding protein 9 family
NX99_RS01320	COG1705	Flagellar rod assembly protein muramidase FlgJ
NX99_RS01320	COG1388	LysM domain
NX99_RS01325	COG0583	DNA-binding transcription factor activity
NX99_RS01330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NX99_RS01335	COG2824	Alkylphosphonate utilization operon protein PhnA
NX99_RS01340	COG0765	amino acid transport
NX99_RS01345	COG1126	abc transporter atp-binding protein
NX99_RS01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS01355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NX99_RS01370	COG1064	alcohol dehydrogenase
NX99_RS01375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NX99_RS01375	COG0519	Catalyzes the synthesis of GMP from XMP
NX99_RS01380	COG2188	Transcriptional regulator
NX99_RS01390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NX99_RS01400	COG1827	regulation of RNA biosynthetic process
NX99_RS01410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NX99_RS01425	COG0758	DNA mediated transformation
NX99_RS01430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NX99_RS01435	COG1131	(ABC) transporter
NX99_RS01500	COG0028	Belongs to the TPP enzyme family
NX99_RS01505	COG3527	Alpha-acetolactate decarboxylase
NX99_RS01525	COG1846	Transcriptional regulator
NX99_RS01540	COG1174	glycine betaine transport
NX99_RS01565	COG1136	(ABC) transporter
NX99_RS01565	COG4591	ABC-type transport system involved in lipoprotein release permease component
NX99_RS01585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NX99_RS01595	COG1122	ATPase activity
NX99_RS01625	COG1230	cation diffusion facilitator family transporter
NX99_RS01635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NX99_RS01670	COG4607	ABC-type enterochelin transport system periplasmic component
NX99_RS01675	COG0534	Mate efflux family protein
NX99_RS01685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NX99_RS01710	COG0167	dihydroorotate dehydrogenase activity
NX99_RS01715	COG0284	orotidine-5'-phosphate decarboxylase activity
NX99_RS01730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS01735	COG0765	amino acid transport
NX99_RS01740	COG0737	Belongs to the 5'-nucleotidase family
NX99_RS01745	COG2207	Transcriptional regulator
NX99_RS01745	COG1917	Cupin 2, conserved barrel domain protein
NX99_RS01755	COG1115	amino acid carrier protein
NX99_RS01760	COG0210	DNA helicase
NX99_RS01765	COG2873	o-acetylhomoserine
NX99_RS01795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NX99_RS01800	COG0196	riboflavin kinase activity
NX99_RS01805	COG1393	Belongs to the ArsC family
NX99_RS01815	COG0483	inositol monophosphate 1-phosphatase activity
NX99_RS01820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NX99_RS01820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NX99_RS01830	COG0573	inorganic phosphate transmembrane transporter activity
NX99_RS01835	COG0581	inorganic phosphate transmembrane transporter activity
NX99_RS01850	COG0704	Plays a role in the regulation of phosphate uptake
NX99_RS01865	COG0095	Lipoate-protein ligase
NX99_RS01875	COG0058	SHG alpha-glucan phosphorylase activity
NX99_RS01880	COG1640	4-alpha-glucanotransferase
NX99_RS01885	COG1609	Transcriptional regulator
NX99_RS01895	COG1175	transmembrane transport
NX99_RS01900	COG3833	ABC-type maltose transport systems, permease component
NX99_RS01905	COG3842	ATPase activity
NX99_RS01915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NX99_RS01920	COG0805	protein transport
NX99_RS01925	COG0672	)-iron permease
NX99_RS01930	COG2837	iron assimilation
NX99_RS01935	COG2822	iron ion transport
NX99_RS01940	COG1523	belongs to the glycosyl hydrolase 13 family
NX99_RS01960	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX99_RS01965	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX99_RS01965	COG0022	dehydrogenase e1 component
NX99_RS01970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NX99_RS02000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NX99_RS02020	COG4667	esterase of the alpha-beta hydrolase superfamily
NX99_RS02045	COG0628	permease
NX99_RS02050	COG0588	phosphoglycerate mutase activity
NX99_RS02065	COG0561	phosphatase activity
NX99_RS02080	COG0438	transferase activity, transferring glycosyl groups
NX99_RS02090	COG0562	UDP-galactopyranose mutase
NX99_RS02095	COG3274	enterobacterial common antigen metabolic process
NX99_RS02110	COG1442	glycosyl transferase family 8
NX99_RS02110	COG1216	Glycosyl transferase, family 2
NX99_RS02115	COG1216	Glycosyl transferase, family 2
NX99_RS02115	COG1442	glycosyl transferase family 8
NX99_RS02125	COG0297	glycogen (starch) synthase activity
NX99_RS02155	COG1316	TRANSCRIPTIONal
NX99_RS02160	COG0813	purine-nucleoside phosphorylase activity
NX99_RS02180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NX99_RS02190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NX99_RS02210	COG1573	uracil-dna glycosylase
NX99_RS02240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NX99_RS02245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NX99_RS02275	COG0860	N-Acetylmuramoyl-L-alanine amidase
NX99_RS02290	COG0628	permease
NX99_RS02295	COG1051	belongs to the nudix hydrolase family
NX99_RS02300	COG2177	Part of the ABC transporter FtsEX involved in
NX99_RS02305	COG2884	Cell division ATP-binding protein ftsE
NX99_RS02310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NX99_RS02315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NX99_RS02325	COG0778	Nitroreductase
NX99_RS02350	COG2348	transferase activity, transferring amino-acyl groups
NX99_RS02355	COG2832	Protein of unknown function (DUF454)
NX99_RS02360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NX99_RS02365	COG5002	protein histidine kinase activity
NX99_RS02370	COG0745	RESPONSE REGULATOR receiver
NX99_RS02375	COG1126	abc transporter atp-binding protein
NX99_RS02380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS02385	COG0765	amino acid transport
NX99_RS02390	COG0765	amino acid transport
NX99_RS02395	COG1126	abc transporter atp-binding protein
NX99_RS02400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS02405	COG0765	amino acid transport
NX99_RS02410	COG0765	amino acid transport
NX99_RS02435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NX99_RS02485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NX99_RS02490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NX99_RS02490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NX99_RS02500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NX99_RS02505	COG1956	GAF domain-containing protein
NX99_RS02510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NX99_RS02530	COG0335	large ribosomal subunit rRNA binding
NX99_RS02535	COG0038	chloride channel
NX99_RS02550	COG0716	FMN binding
NX99_RS02575	COG3842	ATPase activity
NX99_RS02610	COG0469	pyruvate kinase activity
NX99_RS02625	COG0066	3-isopropylmalate dehydratase activity
NX99_RS02630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NX99_RS02650	COG0588	phosphoglycerate mutase activity
NX99_RS02655	COG0167	dihydroorotate dehydrogenase activity
NX99_RS02665	COG0776	regulation of translation
NX99_RS02675	COG2755	lipolytic protein G-D-S-L family
NX99_RS02680	COG1307	EDD domain protein, DegV family
NX99_RS02685	COG0497	DNA recombination
NX99_RS02690	COG1438	arginine binding
NX99_RS02695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NX99_RS02720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NX99_RS02740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NX99_RS02740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NX99_RS02755	COG0300	oxidoreductase activity
NX99_RS02770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NX99_RS02775	COG0772	Belongs to the SEDS family
NX99_RS02780	COG0366	Alpha amylase catalytic
NX99_RS02780	COG5263	repeat protein
NX99_RS02785	COG0366	Alpha amylase catalytic
NX99_RS02785	COG5263	repeat protein
NX99_RS02790	COG5263	repeat protein
NX99_RS02790	COG0366	Alpha amylase catalytic
NX99_RS02830	COG0107	imidazoleglycerol-phosphate synthase activity
NX99_RS02840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NX99_RS02850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NX99_RS02890	COG0647	UMP catabolic process
NX99_RS02900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NX99_RS02915	COG1088	dTDP-glucose 4,6-dehydratase activity
NX99_RS02925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NX99_RS02935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NX99_RS02950	COG2384	SAM-dependent methyltransferase
NX99_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NX99_RS02980	COG3442	glutamine amidotransferase
NX99_RS02985	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NX99_RS02985	COG0392	lysyltransferase activity
NX99_RS03000	COG0488	(ABC) transporter
NX99_RS03010	COG0513	Belongs to the DEAD box helicase family
NX99_RS03050	COG0372	Belongs to the citrate synthase family
NX99_RS03055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NX99_RS03060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NX99_RS03065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX99_RS03070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NX99_RS03080	COG3599	regulation of cell shape
NX99_RS03090	COG0762	integral membrane protein
NX99_RS03100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NX99_RS03110	COG0849	cell division
NX99_RS03135	COG1217	gtp-binding protein TYPA
NX99_RS03140	COG1940	carbohydrate kinase activity
NX99_RS03145	COG4483	Protein conserved in bacteria
NX99_RS03150	COG0735	belongs to the Fur family
NX99_RS03155	COG0783	Belongs to the Dps family
NX99_RS03160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NX99_RS03170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NX99_RS03180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NX99_RS03215	COG0501	Belongs to the peptidase M48B family
NX99_RS03220	COG1704	LemA family
NX99_RS03265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NX99_RS03270	COG4221	oxidoreductase activity
NX99_RS03285	COG0561	phosphatase activity
NX99_RS03300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NX99_RS03305	COG0588	phosphoglycerate mutase activity
NX99_RS03325	COG1705	Flagellar rod assembly protein muramidase FlgJ
NX99_RS03325	COG1388	LysM domain
NX99_RS03345	COG1914	H( )-stimulated, divalent metal cation uptake system
NX99_RS03350	COG4443	Transcriptional Coactivator p15 (PC4)
NX99_RS03360	COG1268	BioY protein
NX99_RS03370	COG0826	peptidase U32
NX99_RS03395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NX99_RS03415	COG2183	response to ionizing radiation
NX99_RS03420	COG0701	Predicted permease
NX99_RS03425	COG3689	TIGRFAM TIGR03943 family protein
NX99_RS03430	COG0659	secondary active sulfate transmembrane transporter activity
NX99_RS03495	COG2226	methyltransferase
NX99_RS03500	COG0508	dehydrogenase complex catalyzes the overall conversion of
NX99_RS03505	COG0022	dehydrogenase e1 component
NX99_RS03510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NX99_RS03515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX99_RS03520	COG3237	CsbD-like
NX99_RS03525	COG2261	transglycosylase associated protein
NX99_RS03535	COG1597	lipid kinase activity
NX99_RS03540	COG2819	hydrolase of the alpha beta superfamily
NX99_RS03550	COG1120	ATPase activity
NX99_RS03580	COG3142	Participates in the control of copper homeostasis
NX99_RS03595	COG2807	transmembrane transport
NX99_RS03670	COG0077	Prephenate dehydratase
NX99_RS03680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NX99_RS03695	COG0287	Prephenate dehydrogenase
NX99_RS03720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NX99_RS03725	COG1368	sulfuric ester hydrolase activity
NX99_RS03840	COG1609	Transcriptional regulator
NX99_RS03845	COG0006	proline dipeptidase activity
NX99_RS03850	COG1185	polyribonucleotide nucleotidyltransferase activity
NX99_RS03865	COG0557	exoribonuclease II activity
NX99_RS03880	COG2814	Major facilitator Superfamily
NX99_RS03885	COG0237	dephospho-CoA kinase activity
NX99_RS03890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NX99_RS03895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NX99_RS03900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NX99_RS03915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NX99_RS03920	COG0768	penicillin binding
NX99_RS03925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NX99_RS03955	COG1126	abc transporter atp-binding protein
NX99_RS03960	COG0765	amino acid transport
NX99_RS03965	COG4703	Protein of unknown function (DUF1797)
NX99_RS03970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NX99_RS03975	COG0542	response to heat
NX99_RS03980	COG0494	nUDIX hydrolase
NX99_RS04020	COG0539	negative regulation of cytoplasmic translation
NX99_RS04040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NX99_RS04070	COG0187	DNA topoisomerase II activity
NX99_RS04090	COG2040	homocysteine
NX99_RS04095	COG0833	amino acid
NX99_RS04110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NX99_RS04120	COG3425	synthase
NX99_RS04135	COG1272	protein, Hemolysin III
NX99_RS04150	COG0596	Alpha beta hydrolase
NX99_RS04165	COG0438	transferase activity, transferring glycosyl groups
NX99_RS04200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NX99_RS04225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NX99_RS04230	COG2267	carboxylic ester hydrolase activity
NX99_RS04240	COG0686	Belongs to the AlaDH PNT family
NX99_RS04245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NX99_RS04250	COG1473	amidohydrolase
NX99_RS04255	COG1187	pseudouridine synthase activity
NX99_RS04295	COG1132	(ABC) transporter
NX99_RS04305	COG0583	DNA-binding transcription factor activity
NX99_RS04310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NX99_RS04330	COG0577	efflux transmembrane transporter activity
NX99_RS04335	COG1136	(ABC) transporter
NX99_RS04355	COG0505	Belongs to the CarA family
NX99_RS04380	COG0564	pseudouridine synthase activity
NX99_RS04450	COG2190	(PTS) system
NX99_RS04450	COG1263	PTS System
NX99_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NX99_RS04460	COG1113	amino acid transport
NX99_RS04490	COG1283	sodium-dependent phosphate transmembrane transporter activity
NX99_RS04515	COG1705	Flagellar rod assembly protein muramidase FlgJ
NX99_RS04515	COG1388	LysM domain
NX99_RS04520	COG0347	Belongs to the P(II) protein family
NX99_RS04525	COG0004	ammonium transporteR
NX99_RS04535	COG4467	Involved in initiation control of chromosome replication
NX99_RS04540	COG1774	PSP1 C-terminal conserved region
NX99_RS04545	COG0470	DNA polymerase III
NX99_RS04565	COG0149	triose-phosphate isomerase activity
NX99_RS04575	COG0772	Belongs to the SEDS family
NX99_RS04610	COG0356	it plays a direct role in the translocation of protons across the membrane
NX99_RS04665	COG2962	Rard protein
NX99_RS04680	COG0726	polysaccharide deacetylase
NX99_RS04685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NX99_RS04690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NX99_RS04695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NX99_RS04705	COG0436	Aminotransferase
NX99_RS04710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NX99_RS04765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NX99_RS04770	COG4122	O-methyltransferase activity
NX99_RS04775	COG2223	nitrite transmembrane transporter activity
NX99_RS04800	COG0583	DNA-binding transcription factor activity
NX99_RS04805	COG0656	L-ascorbic acid biosynthetic process
NX99_RS04810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX99_RS04810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX99_RS04830	COG1702	phosphate starvation-inducible protein PhoH
NX99_RS04865	COG0745	RESPONSE REGULATOR receiver
NX99_RS04870	COG2357	RelA SpoT domain protein
NX99_RS04895	COG0242	peptide deformylase activity
NX99_RS04905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NX99_RS04925	COG0488	(ABC) transporter
NX99_RS04980	COG0301	tRNA thio-modification
NX99_RS04985	COG1104	cysteine desulfurase activity
NX99_RS04995	COG0285	dihydrofolate synthase activity
NX99_RS05005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX99_RS05005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NX99_RS05005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NX99_RS05010	COG1105	Belongs to the carbohydrate kinase PfkB family
NX99_RS05015	COG1349	DNA-binding transcription factor activity
NX99_RS05040	COG0439	Biotin carboxylase
NX99_RS05055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NX99_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
NX99_RS05065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NX99_RS05085	COG1846	Transcriptional regulator
NX99_RS05090	COG1024	Enoyl-CoA hydratase
NX99_RS05095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NX99_RS05100	COG0527	aspartate kinase activity
NX99_RS05195	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NX99_RS05200	COG1739	Uncharacterized protein family UPF0029
NX99_RS05210	COG0517	IMP dehydrogenase activity
NX99_RS05240	COG4471	UPF0298 protein
NX99_RS05270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NX99_RS05275	COG0626	cystathionine gamma-synthase activity
NX99_RS05280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NX99_RS05285	COG2244	polysaccharide biosynthetic process
NX99_RS05305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NX99_RS05315	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NX99_RS05320	COG0195	Participates in both transcription termination and antitermination
NX99_RS05330	COG1316	TRANSCRIPTIONal
NX99_RS05335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NX99_RS05340	COG0802	atpase or kinase
NX99_RS05345	COG2252	PERMEase
NX99_RS05350	COG0561	phosphatase activity
NX99_RS05355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NX99_RS05365	COG3715	PTS system
NX99_RS05370	COG3716	PTS system mannose fructose sorbose family IID component
NX99_RS05385	COG3715	PTS system
NX99_RS05390	COG3716	PTS system mannose fructose sorbose family IID component
NX99_RS05415	COG1484	DNA-dependent DNA replication
NX99_RS05430	COG5002	protein histidine kinase activity
NX99_RS05435	COG0745	RESPONSE REGULATOR receiver
NX99_RS05450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NX99_RS05480	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NX99_RS05490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NX99_RS05500	COG1464	Belongs to the NlpA lipoprotein family
NX99_RS05505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS05520	COG2274	protein secretion by the type I secretion system
NX99_RS05530	COG0671	phosphoesterase, PA-phosphatase related
NX99_RS05535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NX99_RS05545	COG0569	domain protein
NX99_RS05550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NX99_RS05560	COG1187	pseudouridine synthase activity
NX99_RS05570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NX99_RS05590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NX99_RS05605	COG1309	transcriptional regulator
NX99_RS05630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX99_RS05635	COG1254	Belongs to the acylphosphatase family
NX99_RS05650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NX99_RS05670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NX99_RS05680	COG0116	Belongs to the methyltransferase superfamily
NX99_RS05705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NX99_RS05710	COG3579	cysteine-type endopeptidase activity
NX99_RS05725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NX99_RS05730	COG0577	efflux transmembrane transporter activity
NX99_RS05730	COG1136	(ABC) transporter
NX99_RS05740	COG0789	Transcriptional regulator
NX99_RS05750	COG3279	Response regulator of the LytR AlgR family
NX99_RS05790	COG0561	phosphatase activity
NX99_RS05815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NX99_RS05820	COG0564	pseudouridine synthase activity
NX99_RS05850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NX99_RS05850	COG1116	anion transmembrane transporter activity
NX99_RS05855	COG4120	Belongs to the binding-protein-dependent transport system permease family
NX99_RS05870	COG4589	Belongs to the CDS family
NX99_RS05890	COG1132	(ABC) transporter
NX99_RS05895	COG1396	sequence-specific DNA binding
NX99_RS05910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NX99_RS05910	COG2190	(PTS) system
NX99_RS05910	COG1263	PTS System
NX99_RS05920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NX99_RS05925	COG1121	(ABC) transporter
NX99_RS05935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NX99_RS05960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NX99_RS05965	COG0719	Fe-S assembly protein
NX99_RS05975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NX99_RS05995	COG0765	amino acid transport
NX99_RS06000	COG1126	abc transporter atp-binding protein
NX99_RS06040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NX99_RS06065	COG0737	Belongs to the 5'-nucleotidase family
NX99_RS06070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NX99_RS06080	COG0494	nUDIX hydrolase
NX99_RS06090	COG0504	CTP synthase activity
NX99_RS06105	COG0668	transmembrane transport
NX99_RS06145	COG0351	phosphomethylpyrimidine kinase
NX99_RS06165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NX99_RS06180	COG1876	peptidase activity
NX99_RS06185	COG0588	phosphoglycerate mutase activity
NX99_RS06195	COG3830	Belongs to the UPF0237 family
NX99_RS06205	COG4509	Sortase family
NX99_RS06270	COG2217	Heavy metal translocating P-type atpase
NX99_RS06285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NX99_RS06290	COG1476	TRANSCRIPTIONal
NX99_RS06305	COG3688	RNA-binding protein containing a PIN domain
NX99_RS06310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NX99_RS06320	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NX99_RS06330	COG1045	serine acetyltransferase
NX99_RS06345	COG1686	Belongs to the peptidase S11 family
NX99_RS06350	COG1686	Belongs to the peptidase S11 family
NX99_RS06355	COG0542	response to heat
NX99_RS06360	COG4463	regulation of RNA biosynthetic process
NX99_RS06380	COG0450	alkyl hydroperoxide reductase
NX99_RS06385	COG3634	alkyl hydroperoxide reductase activity
NX99_RS06400	COG1846	Transcriptional regulator
NX99_RS06410	COG2309	aminopeptidase activity
NX99_RS06415	COG2176	DNA-directed DNA polymerase activity
NX99_RS06500	COG1393	Belongs to the ArsC family
NX99_RS06510	COG1546	Belongs to the CinA family
NX99_RS06510	COG1058	Belongs to the CinA family
NX99_RS06515	COG0519	Catalyzes the synthesis of GMP from XMP
NX99_RS06555	COG4550	Control of competence regulator ComK, YlbF/YmcA
NX99_RS06570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NX99_RS06580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NX99_RS06610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NX99_RS06615	COG0151	Belongs to the GarS family
NX99_RS06630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NX99_RS06635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NX99_RS06645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NX99_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NX99_RS06670	COG0436	Aminotransferase
NX99_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NX99_RS06835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NX99_RS06840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NX99_RS06850	COG0012	GTP binding
NX99_RS06860	COG0592	DNA-directed DNA polymerase activity
NX99_RS06870	COG1475	DNA binding
NX99_RS06875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NX99_RS06910	COG0488	(ABC) transporter
NX99_RS06915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NX99_RS06945	COG0612	Peptidase, M16
NX99_RS06950	COG0612	Peptidase, M16
NX99_RS06960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NX99_RS06975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NX99_RS06980	COG1388	LysM domain
NX99_RS06980	COG3584	3D domain protein
NX99_RS07000	COG2095	MarC family integral membrane protein
NX99_RS07020	COG0305	Participates in initiation and elongation during chromosome replication
NX99_RS07040	COG3759	membrane
NX99_RS07050	COG1511	domain protein
NX99_RS07050	COG1511	domain protein
NX99_RS07065	COG1695	Transcriptional regulator
NX99_RS07070	COG0494	nUDIX hydrolase
NX99_RS07110	COG5001	Diguanylate cyclase
NX99_RS07110	COG3300	MHYT domain
NX99_RS07115	COG1105	Belongs to the carbohydrate kinase PfkB family
NX99_RS07130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NX99_RS07140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NX99_RS07145	COG2190	(PTS) system
NX99_RS07145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NX99_RS07145	COG1263	PTS System
NX99_RS07170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NX99_RS07180	COG0602	queuosine metabolic process
NX99_RS07190	COG1328	CTP reductase activity
NX99_RS07215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NX99_RS07220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NX99_RS07235	COG0582	viral genome integration into host DNA
NX99_RS07255	COG2855	membrane
NX99_RS07275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NX99_RS07295	COG0051	transcription antitermination factor activity, RNA binding
NX99_RS07365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NX99_RS07400	COG0201	protein transport
NX99_RS07465	COG4475	Protein of unknown function (DUF436)
NX99_RS07470	COG2188	Transcriptional regulator
NX99_RS07475	COG1263	PTS System
NX99_RS07475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NX99_RS07480	COG0366	Alpha amylase catalytic
NX99_RS07485	COG3590	peptidase
NX99_RS07490	COG1012	belongs to the aldehyde dehydrogenase family
NX99_RS07490	COG1454	alcohol dehydrogenase
NX99_RS07510	COG0534	Mate efflux family protein
NX99_RS07520	COG1461	Dihydroxyacetone kinase
NX99_RS07525	COG0129	dihydroxy-acid dehydratase activity
NX99_RS07530	COG0028	Belongs to the TPP enzyme family
NX99_RS07535	COG0440	acetolactate synthase activity
NX99_RS07550	COG4499	WXG100 protein secretion system (Wss), protein YukC
NX99_RS07550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NX99_RS07570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NX99_RS07575	COG1459	type II secretion system
NX99_RS07630	COG1266	CAAX protease self-immunity
NX99_RS07635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NX99_RS07640	COG1363	Peptidase, m42
NX99_RS07650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NX99_RS07660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NX99_RS07700	COG2226	methyltransferase
NX99_RS07705	COG0647	UMP catabolic process
NX99_RS07720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NX99_RS07725	COG0705	Rhomboid family
NX99_RS07725	COG0457	Tetratricopeptide repeat
NX99_RS07730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NX99_RS07750	COG0431	NADPH-dependent FMN reductase
NX99_RS07750	COG1053	succinate dehydrogenase
NX99_RS07750	COG3976	FMN-binding domain protein
NX99_RS07760	COG0756	dUTP diphosphatase activity
NX99_RS07800	COG4166	transmembrane transport
NX99_RS07850	COG0706	membrane insertase activity
NX99_RS07865	COG2249	NAD(P)H dehydrogenase (quinone) activity
NX99_RS07990	COG3118	belongs to the thioredoxin family
NX99_RS07995	COG1832	CoA-binding protein
NX99_RS08000	COG0084	hydrolase, TatD family'
NX99_RS08045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NX99_RS08075	COG0126	phosphoglycerate kinase activity
NX99_RS08085	COG0789	Transcriptional regulator
NX99_RS08090	COG0174	glutamine synthetase
NX99_RS08095	COG3942	CHAP domain
NX99_RS08110	COG1214	PFAM Peptidase M22, glycoprotease
NX99_RS08115	COG0456	acetyltransferase
NX99_RS08125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NX99_RS08135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NX99_RS08140	COG0681	Belongs to the peptidase S26 family
NX99_RS08165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX99_RS08165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NX99_RS08240	COG0006	proline dipeptidase activity
NX99_RS08245	COG2131	deaminase
NX99_RS08250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NX99_RS08265	COG1609	Transcriptional regulator
NX99_RS08270	COG1621	beta-fructofuranosidase activity
NX99_RS08275	COG2190	(PTS) system
NX99_RS08275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NX99_RS08275	COG1263	PTS System
NX99_RS08280	COG1940	carbohydrate kinase activity
NX99_RS08285	COG1482	cell wall glycoprotein biosynthetic process
NX99_RS08295	COG0653	protein targeting
NX99_RS08300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NX99_RS08305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NX99_RS08320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NX99_RS08340	COG3655	Transcriptional regulator
NX99_RS08345	COG0252	asparaginase activity
NX99_RS08350	COG0561	phosphatase activity
NX99_RS08375	COG0443	Heat shock 70 kDa protein
NX99_RS08385	COG1116	anion transmembrane transporter activity
NX99_RS08425	COG1811	Na channel or pump
NX99_RS08430	COG4152	abc transporter atp-binding protein
NX99_RS08440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NX99_RS08445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NX99_RS08490	COG0768	penicillin binding
NX99_RS08500	COG0513	Belongs to the DEAD box helicase family
NX99_RS08505	COG0737	Belongs to the 5'-nucleotidase family
NX99_RS08510	COG4470	Protein conserved in bacteria
NX99_RS08530	COG1132	(ABC) transporter
NX99_RS08535	COG1132	(ABC) transporter
NX99_RS08570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NX99_RS08585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NX99_RS08610	COG1882	Formate acetyltransferase
NX99_RS08625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS08630	COG0765	amino acid transport
NX99_RS08635	COG1126	abc transporter atp-binding protein
NX99_RS08650	COG0742	ribosomal rna small subunit methyltransferase
NX99_RS08655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NX99_RS08660	COG3480	Lon protease (S16) C-terminal proteolytic domain
NX99_RS08665	COG1242	4 iron, 4 sulfur cluster binding
NX99_RS08670	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NX99_RS08695	COG1119	ATPase activity
NX99_RS08700	COG1253	flavin adenine dinucleotide binding
NX99_RS08710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NX99_RS08720	COG0589	response to stress
NX99_RS08725	COG0436	Aminotransferase
NX99_RS08735	COG1335	isochorismatase
NX99_RS08740	COG2723	6-phospho-beta-galactosidase activity
NX99_RS08745	COG1442	glycosyl transferase family 8
NX99_RS08750	COG1216	Glycosyl transferase, family 2
NX99_RS08750	COG1442	glycosyl transferase family 8
NX99_RS08790	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NX99_RS08795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NX99_RS08800	COG1534	Rna-binding protein
NX99_RS08805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NX99_RS08810	COG1713	HD superfamily hydrolase involved in NAD metabolism
NX99_RS08815	COG0799	negative regulation of ribosome biogenesis
NX99_RS08820	COG2226	methyltransferase
NX99_RS08860	COG0537	adenosine 5'-monophosphoramidase activity
NX99_RS08865	COG1131	(ABC) transporter
NX99_RS08895	COG2081	HI0933 family
NX99_RS08915	COG2176	DNA-directed DNA polymerase activity
NX99_RS08920	COG0789	Transcriptional regulator
NX99_RS08930	COG1136	(ABC) transporter
NX99_RS08930	COG4591	ABC-type transport system involved in lipoprotein release permease component
NX99_RS08950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NX99_RS08960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NX99_RS08965	COG0512	Glutamine amidotransferase of anthranilate synthase
NX99_RS08980	COG0135	phosphoribosylanthranilate isomerase activity
NX99_RS08990	COG0159	tryptophan synthase activity
NX99_RS09010	COG2217	Heavy metal translocating P-type atpase
NX99_RS09020	COG1181	Belongs to the D-alanine--D-alanine ligase family
NX99_RS09025	COG0765	amino acid transport
NX99_RS09030	COG0765	amino acid transport
NX99_RS09035	COG1126	abc transporter atp-binding protein
NX99_RS09040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS09060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NX99_RS09090	COG0513	Belongs to the DEAD box helicase family
NX99_RS09100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NX99_RS09110	COG0204	Acyl-transferase
NX99_RS09115	COG1596	polysaccharide export
NX99_RS09115	COG1555	photosystem II stabilization
NX99_RS09120	COG0658	competence protein
NX99_RS09120	COG2333	competence protein COMEC
NX99_RS09125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NX99_RS09130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NX99_RS09135	COG4109	DRTGG domain
NX99_RS09140	COG0024	Methionine aminopeptidase
NX99_RS09150	COG4708	membrane
NX99_RS09160	COG1597	lipid kinase activity
NX99_RS09185	COG0708	Exodeoxyribonuclease III
NX99_RS09205	COG3615	Tellurite resistance protein tehB
NX99_RS09205	COG0500	methyltransferase
NX99_RS09240	COG0285	dihydrofolate synthase activity
NX99_RS09245	COG0531	amino acid
NX99_RS09285	COG1176	ABC-type spermidine putrescine transport system, permease component I
NX99_RS09290	COG1177	transmembrane transport
NX99_RS09305	COG0346	lactoylglutathione lyase activity
NX99_RS09310	COG1940	carbohydrate kinase activity
NX99_RS09325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NX99_RS09330	COG1393	Belongs to the ArsC family
NX99_RS09340	COG1380	Effector of murein hydrolase LrgA
NX99_RS09345	COG1346	cytolysis
NX99_RS09355	COG0187	DNA topoisomerase II activity
NX99_RS09365	COG0560	Phosphoserine phosphatase
NX99_RS09400	COG1187	pseudouridine synthase activity
NX99_RS09425	COG0765	amino acid transport
NX99_RS09450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS09455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS09460	COG0436	Aminotransferase
NX99_RS09465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NX99_RS09470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NX99_RS09475	COG1970	mechanosensitive ion channel activity
NX99_RS09480	COG0358	DNA primase activity
NX99_RS09485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NX99_RS09490	COG2151	metal-sulfur cluster biosynthetic enzyme
NX99_RS09495	COG0463	Glycosyl transferase, family 2
NX99_RS09505	COG1091	dTDP-4-dehydrorhamnose reductase activity
NX99_RS09515	COG1216	Glycosyl transferase, family 2
NX99_RS09520	COG1216	Glycosyl transferase, family 2
NX99_RS09525	COG0463	Glycosyl transferase, family 2
NX99_RS09545	COG1216	Glycosyl transferase, family 2
NX99_RS09545	COG1442	glycosyl transferase family 8
NX99_RS09565	COG0463	Glycosyl transferase, family 2
NX99_RS09585	COG2003	Belongs to the UPF0758 family
NX99_RS09590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NX99_RS09605	COG1104	cysteine desulfurase activity
NX99_RS09620	COG2357	RelA SpoT domain protein
NX99_RS09630	COG0564	pseudouridine synthase activity
NX99_RS09635	COG0280	phosphate acetyltransferase
NX99_RS09640	COG4166	transmembrane transport
NX99_RS09645	COG4166	transmembrane transport
NX99_RS09650	COG0601	transmembrane transport
NX99_RS09655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NX99_RS09660	COG0444	Belongs to the ABC transporter superfamily
NX99_RS09665	COG4608	Belongs to the ABC transporter superfamily
NX99_RS09675	COG1131	(ABC) transporter
NX99_RS09680	COG1725	Transcriptional regulator
NX99_RS09685	COG0561	phosphatase activity
NX99_RS09690	COG0561	phosphatase activity
NX99_RS09695	COG0552	protein localization to endoplasmic reticulum
NX99_RS09710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NX99_RS09720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NX99_RS09720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NX99_RS09730	COG2815	serine threonine protein kinase
NX99_RS09730	COG0515	serine threonine protein kinase
NX99_RS09735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NX99_RS09745	COG4585	Histidine kinase
NX99_RS09750	COG2197	response regulator
NX99_RS09785	COG1523	belongs to the glycosyl hydrolase 13 family
NX99_RS09790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NX99_RS09795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NX99_RS09800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NX99_RS09805	COG0297	glycogen (starch) synthase activity
NX99_RS09810	COG0058	SHG alpha-glucan phosphorylase activity
NX99_RS09835	COG1132	(ABC) transporter
NX99_RS09840	COG1132	(ABC) transporter