locus-tag class description HRE60_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HRE60_RS00020 ENOG4105C3G gtp-binding protein HRE60_RS00030 ENOG4108JA2 transcriptioN-repair coupling factor HRE60_RS00035 ENOG41082I2 s4 domain protein HRE60_RS00065 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HRE60_RS00195 ENOG4105CHM Aminotransferase HRE60_RS00220 ENOG4107QIK phosphoribosylformylglycinamidine synthase HRE60_RS00225 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HRE60_RS00230 ENOG4105CXB phosphoribosylaminoimidazole synthetase HRE60_RS00235 ENOG4108V3E phosphoribosylglycinamide formyltransferase HRE60_RS00250 ENOG4105C12 Phosphoribosylglycinamide synthetase HRE60_RS00255 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HRE60_RS00275 ENOG4105C83 adenylosuccinate lyase HRE60_RS00330 ENOG4108R3E Dna-3-methyladenine glycosylase i HRE60_RS00345 ENOG410888K transcriptional regulator, Spx HRE60_RS00430 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HRE60_RS00435 ENOG4105C88 aminopeptidase HRE60_RS00460 ENOG4108JU3 Alkyl hydroperoxide reductase HRE60_RS00465 ENOG4105D3R alkyl hydroperoxide reductase HRE60_RS00490 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRE60_RS00515 ENOG4105D7W serine acetyltransferase HRE60_RS00525 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HRE60_RS00535 ENOG4105C2N RNA methyltransferase TrmH family group 3 HRE60_RS00540 ENOG4105M0M Tetracycline resistance protein HRE60_RS00545 ENOG4105EPR degv family HRE60_RS00555 ENOG4105VZ8 Transcriptional regulator HRE60_RS00560 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HRE60_RS00585 ENOG4105CNU cell division protein FtsK HRE60_RS00620 ENOG4105KFN sortase, SrtB family HRE60_RS00630 ENOG4105VUC UPF0237 protein HRE60_RS00640 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRE60_RS00645 ENOG4108VXD carboxy-peptidase HRE60_RS00660 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HRE60_RS00685 ENOG4105DWF phosphomethylpyrimidine kinase HRE60_RS00725 ENOG4105D8X mechanosensitive ion channel HRE60_RS00740 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HRE60_RS00750 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HRE60_RS00760 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HRE60_RS00765 ENOG4105CGH 5'-nucleotidase HRE60_RS00785 ENOG4107PMM dextranase HRE60_RS00790 ENOG4105C7B Threonine dehydratase HRE60_RS00825 ENOG4105CDA abc transporter atp-binding protein HRE60_RS00830 ENOG4105E5Q amino acid AbC transporter HRE60_RS00850 ENOG4105ESV Glycosyl transferase, family 4 HRE60_RS00860 ENOG4105JRK feS assembly protein SufD HRE60_RS00865 ENOG4105C9B Cysteine desulfurase HRE60_RS00870 ENOG4108UNV SUF system FeS assembly protein, NifU family HRE60_RS00890 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRE60_RS00900 ENOG4105FDK ABC transporter HRE60_RS00915 ENOG4105CI1 PTS System HRE60_RS00930 ENOG4105WT3 Transcriptional regulator HRE60_RS00935 ENOG4105BZ1 (ABC) transporter HRE60_RS00955 ENOG4105KNE Phosphatidate cytidylyltransferase HRE60_RS00970 ENOG4105C7J ABC transporter, permease HRE60_RS00975 ENOG4105D7T ABC transporter HRE60_RS00980 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HRE60_RS01005 ENOG4108YBP pseudouridine synthase HRE60_RS01010 ENOG4105BZ4 penicillin-binding protein HRE60_RS01035 ENOG410667J hydrolase HRE60_RS01040 ENOG4105E98 transcriptional regulator DeoR family HRE60_RS01075 ENOG4105DY9 regulatoR HRE60_RS01095 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRE60_RS01100 ENOG4105DAP Nicotinate phosphoribosyltransferase HRE60_RS01115 ENOG4105CTZ aminopeptidase c HRE60_RS01120 ENOG4105BZ4 penicillin-binding protein HRE60_RS01145 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HRE60_RS01150 ENOG41070VT HRE60_RS01150 ENOG41070VT HRE60_RS01155 ENOG4105C0D helicase HRE60_RS01185 ENOG4108RS6 transposase HRE60_RS01200 ENOG4108RWN rrna methyltransferase HRE60_RS01225 ENOG4105ST3 Transcriptional regulator HRE60_RS01240 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HRE60_RS01260 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HRE60_RS01265 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HRE60_RS01270 ENOG4105FE9 pseudouridine synthase HRE60_RS01280 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HRE60_RS01285 ENOG4105C1A potassium transporter peripheral membrane HRE60_RS01295 ENOG4108SAX Membrane HRE60_RS01300 ENOG410841Q phosphoesterase PA-phosphatase related protein HRE60_RS01310 ENOG4108JJA ABC, transporter HRE60_RS01330 ENOG4105D01 (LipO)protein HRE60_RS01340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HRE60_RS01345 ENOG4108UMI ABC transporter, permease HRE60_RS01365 ENOG4108JJB ABC transporter HRE60_RS01380 ENOG4105CZN Potassium uptake protein HRE60_RS01395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HRE60_RS01400 ENOG4105GR3 Histidine kinase HRE60_RS01440 ENOG4105F3R pts system mannose fructose sorbose family iid HRE60_RS01445 ENOG4105ETZ PTS System HRE60_RS01460 ENOG4105F3R pts system mannose fructose sorbose family iid HRE60_RS01465 ENOG4105ETZ PTS System HRE60_RS01475 ENOG4106IPI cyclase, family HRE60_RS01480 ENOG4108KP7 hydrolase HRE60_RS01485 ENOG4105C7N Xanthine uracil vitamin C permease HRE60_RS01490 ENOG4105K8N protein family UPF0079, ATPase HRE60_RS01495 ENOG4108MK9 spermidine N(1)-acetyltransferase HRE60_RS01500 ENOG4108KGH TRANSCRIPTIONal HRE60_RS01510 ENOG4105CHV Transcription elongation factor NusA HRE60_RS01515 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HRE60_RS01525 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HRE60_RS01535 ENOG4108URH decarboxylase HRE60_RS01555 ENOG4105C28 cystathionine HRE60_RS01560 ENOG4105C87 Aminotransferase class I and II HRE60_RS01570 ENOG4105EDQ levansucrase EC 2.4.1.10 HRE60_RS01575 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HRE60_RS01590 ENOG4105WUC UPF0298 protein HRE60_RS01595 ENOG4105CP9 extracellular ligand-binding receptor HRE60_RS01600 ENOG4105C32 Amino acid ABC transporter (Permease) HRE60_RS01605 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRE60_RS01610 ENOG4105C0Z ABC transporter HRE60_RS01615 ENOG4108IV0 ABC, transporter HRE60_RS01620 ENOG41080XP Cbs domain HRE60_RS01630 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HRE60_RS01730 ENOG4105CFH Aspartokinase HRE60_RS01735 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HRE60_RS01740 ENOG4105CGU Enoyl-CoA hydratase HRE60_RS01745 ENOG4105K56 Transcriptional regulator HRE60_RS01760 ENOG4105EA8 2-Nitropropane dioxygenase HRE60_RS01765 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HRE60_RS01770 ENOG4105CHR reductase HRE60_RS01775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRE60_RS01790 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HRE60_RS01815 ENOG4105E98 transcriptional regulator DeoR family HRE60_RS01820 ENOG4105DE4 1-phosphofructokinase HRE60_RS01825 ENOG4105DM4 PTS System HRE60_RS01830 ENOG4105DC8 reductase HRE60_RS01835 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HRE60_RS01845 ENOG4105C3J Cysteine desulfurase HRE60_RS01850 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HRE60_RS01855 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HRE60_RS01905 ENOG4105C5H ABC transporter HRE60_RS01920 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HRE60_RS01925 ENOG4105D82 Glutamate dehydrogenase HRE60_RS01935 ENOG4107YDN peptide deformylase HRE60_RS01965 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRE60_RS02000 ENOG4105C9A Phoh family HRE60_RS02020 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HRE60_RS02025 ENOG4105CV8 reductase HRE60_RS02030 ENOG4105F04 LysR family Transcriptional regulator HRE60_RS02065 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HRE60_RS02105 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HRE60_RS02130 ENOG4105C8Y Acetylornithine aminotransferase HRE60_RS02135 ENOG4107BJW polysaccharide deacetylase HRE60_RS02140 ENOG4105D6E homoserine dehydrogenase HRE60_RS02150 ENOG4105FR1 rard protein HRE60_RS02170 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HRE60_RS02195 ENOG4105ZA1 atp synthase HRE60_RS02200 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HRE60_RS02235 ENOG4105CNI cell division protein FtsW HRE60_RS02245 ENOG4105CP7 Triose-phosphate isomerase HRE60_RS02265 ENOG4105FA2 dna polymerase iii HRE60_RS02270 ENOG4105MA4 psp1 domain protein HRE60_RS02275 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) HRE60_RS02280 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HRE60_RS02285 ENOG4105BZU Histidine kinase HRE60_RS02290 ENOG4108YZA Nitrogen regulatory protein pii HRE60_RS02295 ENOG4107X35 defense response to bacterium HRE60_RS02320 ENOG4105CE4 GlcNAc 6-P deacetylase HRE60_RS02345 ENOG4105C85 amino acid HRE60_RS02355 ENOG4105C5Y PTS System HRE60_RS02405 ENOG4105C34 Pseudouridine synthase HRE60_RS02425 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HRE60_RS02445 ENOG4105C19 ABC transporter HRE60_RS02450 ENOG4107RBB ABC transporter, permease HRE60_RS02470 ENOG4105BZ1 (ABC) transporter HRE60_RS02515 ENOG4105CH2 amidohydrolase HRE60_RS02520 ENOG4105DCF alanine dehydrogenase HRE60_RS02530 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HRE60_RS02535 ENOG4107QN2 dihydrolipoyl dehydrogenase HRE60_RS02560 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HRE60_RS02590 ENOG4105W2C Glycosyl transferase HRE60_RS02595 ENOG4105BZF Glycosyl transferase (Group 1 HRE60_RS02625 ENOG4108UT2 hemolysin iii HRE60_RS02640 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HRE60_RS02650 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HRE60_RS02670 ENOG4108IQI permease HRE60_RS02675 ENOG4108J5H Homocysteine s-methyltransferase HRE60_RS02695 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRE60_RS02705 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HRE60_RS02715 ENOG4105CM2 brancheD-chain amino acid aminotransferase HRE60_RS02735 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HRE60_RS02775 ENOG4105M6F mutator MutT protein HRE60_RS02780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRE60_RS02790 ENOG4107IN1 Protein of unknown function (DUF1797) HRE60_RS02795 ENOG4105E5Q amino acid AbC transporter HRE60_RS02800 ENOG4105CDA abc transporter atp-binding protein HRE60_RS02810 ENOG4105CE1 Ferrous iron transport protein b HRE60_RS02830 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HRE60_RS02835 ENOG4107RF6 penicillin-binding protein HRE60_RS02840 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HRE60_RS02855 ENOG4107YR5 Diacylglycerol kinase HRE60_RS02860 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HRE60_RS02865 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HRE60_RS02870 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HRE60_RS02875 ENOG4105C6X Major Facilitator HRE60_RS02890 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HRE60_RS02905 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HRE60_RS02910 ENOG4105DC7 peptidase M24 HRE60_RS02915 ENOG4105ETE Transcriptional regulator (LacI family HRE60_RS02925 ENOG4105BZW Glycerate kinase HRE60_RS02950 ENOG4105DR4 Methyltransferase HRE60_RS02975 ENOG4105EVN Prephenate dehydrogenase HRE60_RS02990 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HRE60_RS03000 ENOG4105CQC Prephenate dehydratase HRE60_RS03005 ENOG4108RCF TRANSCRIPTIONal HRE60_RS03055 ENOG41086D8 Transcriptional regulator HRE60_RS03060 ENOG4108UYN gCN5-related N-acetyltransferase HRE60_RS03075 ENOG4108IG5 Transcriptional regulator HRE60_RS03115 ENOG4105DJ2 Major Facilitator Superfamily HRE60_RS03155 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRE60_RS03175 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HRE60_RS03180 ENOG4105E0A ABC, transporter HRE60_RS03190 ENOG4108SA1 esterase HRE60_RS03195 ENOG4106ZEE Diacylglycerol kinase HRE60_RS03205 ENOG4107BMA Transglycosylase associated protein HRE60_RS03210 ENOG41061M1 UPF0337 protein HRE60_RS03220 ENOG4107RUY (E1 component), alpha subunit HRE60_RS03230 ENOG4107QKR Dehydrogenase HRE60_RS03290 ENOG4105CHH sulfate transporter HRE60_RS03295 ENOG4108NNR transporter substrate-binding protein HRE60_RS03300 ENOG4108PJD permease HRE60_RS03325 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HRE60_RS03350 ENOG4105CFP Peptidase U32 HRE60_RS03360 ENOG4105VKD bioY protein HRE60_RS03370 ENOG4105VEM Conserved domain protein HRE60_RS03375 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HRE60_RS03385 ENOG4105M6F mutator MutT protein HRE60_RS03420 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRE60_RS03425 ENOG4108Z66 YbaK ebsC protein HRE60_RS03440 ENOG4108K4B hydrolase HRE60_RS03455 ENOG4105EMU Dehydrogenase HRE60_RS03460 ENOG4105DZR Type I site-specific deoxyribonuclease HRE60_RS03510 ENOG4108V0P LemA family HRE60_RS03515 ENOG4105D0M Protease HtpX homolog HRE60_RS03530 ENOG4105CC5 ABC transporter HRE60_RS03535 ENOG4105DIK (ABC) transporter HRE60_RS03550 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HRE60_RS03560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRE60_RS03575 ENOG4105HUF DNA protection during starvation protein HRE60_RS03580 ENOG4105G5W regulator Fur family HRE60_RS03590 ENOG4105DKQ ROK family HRE60_RS03595 ENOG4105CI3 gtp-binding protein typa HRE60_RS03620 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HRE60_RS03630 ENOG4105DFA alanine racemase domain protein HRE60_RS03640 ENOG4108VIA integral membrane protein HRE60_RS03650 ENOG4105MMF Cell division protein DIVIVA HRE60_RS03660 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRE60_RS03665 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRE60_RS03670 ENOG41067VN Glutaredoxin HRE60_RS03675 ENOG4108I0Z Aconitate hydratase HRE60_RS03680 ENOG4105BZN citrate synthase HRE60_RS03685 ENOG4108HMX isocitrate dehydrogenase (NADP) HRE60_RS03690 ENOG4105KRI phosphocarrier protein (HPr HRE60_RS03695 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HRE60_RS03700 ENOG4105C26 Dehydrogenase HRE60_RS03720 ENOG4105FDU atp-dependent rna helicase HRE60_RS03730 ENOG4105C5H ABC transporter HRE60_RS03750 ENOG4105F1K Glutamine amidotransferase HRE60_RS03755 ENOG4105DMS mur ligase HRE60_RS03795 ENOG4107VFR oxidoreductase HRE60_RS03805 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HRE60_RS03815 ENOG4105C1B dTDP-glucose 4-6-dehydratase HRE60_RS03830 ENOG4105CSA Coproporphyrinogen iii oxidase HRE60_RS03840 ENOG4105D4U had-superfamily hydrolase, subfamily iia HRE60_RS03880 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HRE60_RS03890 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HRE60_RS03900 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HRE60_RS03960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HRE60_RS03975 ENOG4108IXY short-chain dehydrogenase reductase HRE60_RS03985 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HRE60_RS04005 ENOG4105CSM endonuclease III HRE60_RS04030 ENOG4105DX0 Hemolysin A HRE60_RS04035 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HRE60_RS04040 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HRE60_RS04045 ENOG4108RCR degv family HRE60_RS04050 ENOG41090WU lipolytic protein G-D-S-L family HRE60_RS04060 ENOG4105K70 DNA-binding protein HRE60_RS04070 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HRE60_RS04075 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRE60_RS04095 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HRE60_RS04100 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HRE60_RS04115 ENOG4105CA9 Pyruvate kinase HRE60_RS04140 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRE60_RS04150 ENOG4107UWA esterase HRE60_RS04165 ENOG4105NQC Flavodoxin HRE60_RS04170 ENOG4105CMQ Chloride channel HRE60_RS04180 ENOG4107R4J Chloride channel HRE60_RS04185 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HRE60_RS04205 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HRE60_RS04215 ENOG4105C6E dna polymerase iii HRE60_RS04225 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HRE60_RS04280 ENOG4105CMR udp-glucose 4-epimerase HRE60_RS04300 ENOG4105ZT7 DNA-entry nuclease HRE60_RS04305 ENOG4105DRP amino acid AbC transporter HRE60_RS04310 ENOG4105EAD ABC transporter HRE60_RS04315 ENOG4107RP9 extracellular solute-binding protein, family 3 HRE60_RS04320 ENOG4105CDA abc transporter atp-binding protein HRE60_RS04325 ENOG4105DRP amino acid AbC transporter HRE60_RS04330 ENOG4105EAD ABC transporter HRE60_RS04335 ENOG4107RP9 extracellular solute-binding protein, family 3 HRE60_RS04340 ENOG4105CDA abc transporter atp-binding protein HRE60_RS04345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HRE60_RS04350 ENOG4105BZU Histidine kinase HRE60_RS04355 ENOG4105Q2H domain protein HRE60_RS04360 ENOG4105WD1 Membrane HRE60_RS04390 ENOG4108DBC nitroreductase HRE60_RS04400 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HRE60_RS04410 ENOG4105CAK Cell division ATP-binding protein ftsE HRE60_RS04415 ENOG4105CRP Part of the ABC transporter FtsEX involved in HRE60_RS04435 ENOG4105C3F Signal peptidase i HRE60_RS04440 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HRE60_RS04470 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HRE60_RS04475 ENOG4105VJV 50s ribosomal protein L35 HRE60_RS04525 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HRE60_RS04535 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HRE60_RS04545 ENOG41089BK Glutamine amido-transferase HRE60_RS04550 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HRE60_RS04555 ENOG4108KGH TRANSCRIPTIONal HRE60_RS04585 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HRE60_RS04615 ENOG4105D5D udp-galactopyranose mutase HRE60_RS04625 ENOG4105GH9 galactofuranosyltransferase HRE60_RS04635 ENOG4108HCJ Hydrolase HRE60_RS04650 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRE60_RS04655 ENOG4105C02 permease HRE60_RS04680 ENOG4108NRW Phospholipase, patatin family HRE60_RS04725 ENOG4107RUY (E1 component), alpha subunit HRE60_RS04730 ENOG4105CPP Dehydrogenase, E1 component HRE60_RS04735 ENOG4107QKR Dehydrogenase HRE60_RS04750 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRE60_RS04755 ENOG4108IUM Glycogen debranching enzyme HRE60_RS04760 ENOG4105DHS permease protein HRE60_RS04765 ENOG4105CM4 permease protein HRE60_RS04770 ENOG4108IPW abc transporter atp-binding protein HRE60_RS04780 ENOG410650H (LipO)protein HRE60_RS04785 ENOG4105DBE peroxidase HRE60_RS04790 ENOG4107SJW iron permease, FTR1 HRE60_RS04795 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HRE60_RS04810 ENOG4108IJ9 (ABC) transporter HRE60_RS04815 ENOG4105EG2 ABC transporter, permease HRE60_RS04820 ENOG4105D56 permease protein HRE60_RS04835 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) HRE60_RS04840 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRE60_RS04850 ENOG4105DF9 Lipoate-protein, ligase HRE60_RS04865 ENOG4108UTW Plays a role in the regulation of phosphate uptake HRE60_RS04880 ENOG4105E2Z phosphate ABC transporter (Permease HRE60_RS04885 ENOG4105C8U phosphate abc transporter HRE60_RS04895 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HRE60_RS04900 ENOG4105ECY inositol monophosphatase HRE60_RS04910 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HRE60_RS04915 ENOG4105DTN riboflavin biosynthesis protein ribF HRE60_RS04920 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HRE60_RS04940 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HRE60_RS04955 ENOG4105C4R Atp-dependent dna helicase HRE60_RS04960 ENOG4105BZG amino acid carrier protein HRE60_RS04970 ENOG4106AXJ AraC family transcriptional regulator HRE60_RS04975 ENOG4105CGH 5'-nucleotidase HRE60_RS04980 ENOG4105E5Q amino acid AbC transporter HRE60_RS04985 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HRE60_RS05000 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HRE60_RS05015 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HRE60_RS05045 ENOG4107QJQ Mate efflux family protein HRE60_RS05060 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HRE60_RS05080 ENOG4105CPQ Dehydrogenase HRE60_RS05090 ENOG4105PGM cation diffusion facilitator family transporter HRE60_RS05120 ENOG4105JAB phenazine biosynthesis protein, phzf family HRE60_RS05130 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRE60_RS05150 ENOG4105E90 ABC transporter HRE60_RS05170 ENOG4105K56 Transcriptional regulator HRE60_RS05175 ENOG4107FQX Alpha-acetolactate decarboxylase HRE60_RS05205 ENOG4105CHR reductase HRE60_RS05220 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HRE60_RS05245 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRE60_RS05250 ENOG4105C79 DNA protecting protein DprA HRE60_RS05255 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HRE60_RS05265 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HRE60_RS05275 ENOG4108Z3G 3H domain protein HRE60_RS05280 ENOG4105RNB HRE60_RS05285 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HRE60_RS05300 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HRE60_RS05310 ENOG4105DQ4 alcohol dehydrogenase HRE60_RS05325 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRE60_RS05330 ENOG4108HW3 (ABC) transporter HRE60_RS05335 ENOG4105CDA abc transporter atp-binding protein HRE60_RS05340 ENOG4105E5Q amino acid AbC transporter HRE60_RS05345 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HRE60_RS05350 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HRE60_RS05355 ENOG4107RSM transcriptional regulator HRE60_RS05360 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase HRE60_RS05380 ENOG4105DSE periplasmic solute binding protein HRE60_RS05425 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HRE60_RS05430 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HRE60_RS05440 ENOG4105KME endoribonuclease L-psp HRE60_RS05450 ENOG4105C5S asparaginyl-tRNA synthetase HRE60_RS05455 ENOG4105CHM Aminotransferase HRE60_RS05465 ENOG4105DVT helicase HRE60_RS05480 ENOG4105UIB (ABC) transporter HRE60_RS05485 ENOG4108JQ9 ABC transporter HRE60_RS05490 ENOG4105DIH basic membrane HRE60_RS05495 ENOG4105KG3 cytidine deaminase HRE60_RS05500 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HRE60_RS05505 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HRE60_RS05510 ENOG4107Y49 methyltransferase HRE60_RS05525 ENOG4105US7 Histidine kinase HRE60_RS05530 ENOG4108STX response regulator HRE60_RS05545 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HRE60_RS05550 ENOG4105FH5 Membrane HRE60_RS05560 ENOG4105SYT Methylenetetrahydrofolate reductase HRE60_RS05575 ENOG4105CRQ synthase (Component I) HRE60_RS05580 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HRE60_RS05585 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HRE60_RS05595 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HRE60_RS05610 ENOG4105BZ1 (ABC) transporter HRE60_RS05635 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRE60_RS05640 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HRE60_RS05650 ENOG4107104 thymidine kinase HRE60_RS05655 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HRE60_RS05665 ENOG4105SFS phosphoesterase RecJ domain protein HRE60_RS05680 ENOG4105K3M )-transporter HRE60_RS05690 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HRE60_RS05695 ENOG4108Z6X (sortase) family HRE60_RS05715 ENOG4105C5H ABC transporter HRE60_RS05745 ENOG4108RS6 transposase HRE60_RS05750 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HRE60_RS05785 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HRE60_RS05800 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRE60_RS05810 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HRE60_RS05820 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HRE60_RS05825 ENOG4105C94 Transporter HRE60_RS05830 ENOG4107PBV potassium channel HRE60_RS05855 ENOG4105EJQ L-serine dehydratase HRE60_RS05860 ENOG4105D7K pfkb domain protein HRE60_RS05910 ENOG4108ZGX Histidine kinase HRE60_RS05920 ENOG4108M15 ABC transporter HRE60_RS05935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HRE60_RS05950 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HRE60_RS05985 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HRE60_RS05990 ENOG4105F7F Chaperone HRE60_RS05995 ENOG4105C09 Bile acid HRE60_RS06010 ENOG4108M15 ABC transporter HRE60_RS06035 ENOG4105C19 ABC transporter HRE60_RS06045 ENOG4105CJZ response regulator HRE60_RS06055 ENOG4105C2W permease HRE60_RS06075 ENOG4107QMU Mate efflux family protein HRE60_RS06080 ENOG4105E0X reductase HRE60_RS06085 ENOG4105CWM branched-chain amino acid transport system II carrier protein HRE60_RS06090 ENOG4105DG6 mannose-6-phosphate isomerase HRE60_RS06120 ENOG4105CUB amino acid HRE60_RS06135 ENOG4108V06 Glutathione peroxidase HRE60_RS06160 ENOG4107RGM aldo keto reductase HRE60_RS06170 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HRE60_RS06175 ENOG4108Z40 Transcriptional regulator HRE60_RS06185 ENOG4105CK1 PTS System HRE60_RS06190 ENOG4108TVJ Nitroreductase HRE60_RS06205 ENOG4105CMR udp-glucose 4-epimerase HRE60_RS06220 ENOG4105CQ4 Transcriptional regulator HRE60_RS06225 ENOG4105CG3 alpha amylase, catalytic region HRE60_RS06230 ENOG4107RK0 Sucrose phosphorylase HRE60_RS06235 ENOG4107Y7Q pfkb domain protein HRE60_RS06240 ENOG4108IJ9 (ABC) transporter HRE60_RS06255 ENOG4107YY3 extracellular solute-binding protein family 1 HRE60_RS06260 ENOG4105DME alpha-galactosidase HRE60_RS06265 ENOG4108R6W Transcriptional regulator, ARAC family HRE60_RS06270 ENOG4105CG3 alpha amylase, catalytic region HRE60_RS06275 ENOG4105BZU Histidine kinase HRE60_RS06280 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HRE60_RS06285 ENOG4107WD8 ABC transporter, permease HRE60_RS06320 ENOG4105VDH Dihydroxyacetone kinase HRE60_RS06325 ENOG4108UTZ Dihydroxyacetone kinase HRE60_RS06330 ENOG4105CMT Dihydroxyacetone kinase HRE60_RS06350 ENOG4105C9K Endothelin-converting enzyme 1 HRE60_RS06375 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HRE60_RS06385 ENOG4108IJ6 ABC transporter HRE60_RS06440 ENOG4108N67 choline binding protein HRE60_RS06495 ENOG4108N2Y auxin Efflux HRE60_RS06500 ENOG4105C6K Malic enzyme HRE60_RS06510 ENOG4107ZGM malolactic fermentation system HRE60_RS06520 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRE60_RS06530 ENOG4108UW5 maltose o-acetyltransferase HRE60_RS06535 ENOG4105E8R UPF0173 metal-dependent hydrolase HRE60_RS06570 ENOG4105GH9 galactofuranosyltransferase HRE60_RS06585 ENOG4105EDE A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity) HRE60_RS06590 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HRE60_RS06595 ENOG4108MGR Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) HRE60_RS06625 ENOG4105EYH Exonuclease HRE60_RS06630 ENOG4107RFY SbcCD D subunit HRE60_RS06640 ENOG4105EEN pathogenesis HRE60_RS06685 ENOG4105C5H ABC transporter HRE60_RS06690 ENOG4105BZ1 (ABC) transporter HRE60_RS06695 ENOG4105BZ1 (ABC) transporter HRE60_RS06725 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HRE60_RS06735 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HRE60_RS06740 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HRE60_RS06745 ENOG4108IUM Glycogen debranching enzyme HRE60_RS06780 ENOG4105WH1 Two component transcriptional regulator luxr family HRE60_RS06785 ENOG4105ENE Histidine kinase HRE60_RS06800 ENOG4105D9P serine threonine protein kinase HRE60_RS06810 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HRE60_RS06820 ENOG4105C25 Primosomal protein n' HRE60_RS06835 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HRE60_RS06840 ENOG410667J hydrolase HRE60_RS06845 ENOG4108HCJ Hydrolase HRE60_RS06850 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HRE60_RS06855 ENOG4105CZV ABC transporter HRE60_RS06865 ENOG4108JQ7 (ABC) transporter HRE60_RS06870 ENOG4105C3U ABC transporter HRE60_RS06875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRE60_RS06880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRE60_RS06885 ENOG4105DIB Oligopeptide-binding protein HRE60_RS06890 ENOG4105DIB Oligopeptide-binding protein HRE60_RS06895 ENOG4108IJ2 phosphate acetyltransferase HRE60_RS06900 ENOG4105EMS pseudouridine synthase HRE60_RS06925 ENOG4105C3J Cysteine desulfurase HRE60_RS06960 ENOG4105EY8 ABC transporter HRE60_RS06970 ENOG4105K64 Glycosyl transferase, family 2 HRE60_RS07005 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HRE60_RS07010 ENOG4105CKK Glycosyl transferase, family 2 HRE60_RS07015 ENOG4105VG1 fes assembly suf system protein HRE60_RS07020 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRE60_RS07025 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HRE60_RS07030 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HRE60_RS07035 ENOG4105VCC 30S ribosomal protein S21 HRE60_RS07040 ENOG4107R0W ABC transporter HRE60_RS07045 ENOG4105CHM Aminotransferase HRE60_RS07050 ENOG4107R0W ABC transporter HRE60_RS07055 ENOG4107R0W ABC transporter HRE60_RS07060 ENOG4108Z4K mutator MutT protein HRE60_RS07080 ENOG4105E5Q amino acid AbC transporter HRE60_RS07140 ENOG4105EAC phosphoserine phosphatase HRE60_RS07150 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRE60_RS07160 ENOG41067MG lrgb family HRE60_RS07165 ENOG4105VAW lrga family HRE60_RS07175 ENOG41080E8 Transcriptional regulator, Spx MgsR family HRE60_RS07180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRE60_RS07185 ENOG4108JQ1 Dehydrogenase HRE60_RS07200 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HRE60_RS07215 ENOG4108HM4 ABC transporter HRE60_RS07220 ENOG4105D38 putrescine abc transporter HRE60_RS07225 ENOG4105F38 ABC transporter, permease HRE60_RS07265 ENOG4105C0X amino acid HRE60_RS07270 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HRE60_RS07275 ENOG4105VB6 UPF0109 protein HRE60_RS07305 ENOG41088CC tellurite resistance protein tehB HRE60_RS07320 ENOG4105CGK Exodeoxyribonuclease III HRE60_RS07345 ENOG4105CBD Diacylglycerol kinase HRE60_RS07355 ENOG410807C QueT transporter HRE60_RS07375 ENOG4108Z9I -acetyltransferase HRE60_RS07380 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HRE60_RS07385 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HRE60_RS07390 ENOG4105KQC Competence protein HRE60_RS07395 ENOG4105F6E Acyl-transferase HRE60_RS07400 ENOG4108ZJ4 polysaccharide deacetylase HRE60_RS07405 ENOG41060K3 Methyltransferase HRE60_RS07420 ENOG4105C1J atp-dependent rna helicase HRE60_RS07430 ENOG4105KWG Pfam:DUF1696 HRE60_RS07440 ENOG4105WT3 Transcriptional regulator HRE60_RS07460 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HRE60_RS07480 ENOG4105CT1 (ABC) transporter HRE60_RS07485 ENOG4105CDA abc transporter atp-binding protein HRE60_RS07490 ENOG4105DRP amino acid AbC transporter HRE60_RS07495 ENOG4105E5Q amino acid AbC transporter HRE60_RS07500 ENOG4105CPF Cell wall formation (By similarity) HRE60_RS07510 ENOG4105C59 p-type ATPase HRE60_RS07520 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HRE60_RS07525 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HRE60_RS07530 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HRE60_RS07545 ENOG4105DDQ anthranilate synthase HRE60_RS07550 ENOG4105CRQ synthase (Component I) HRE60_RS07555 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HRE60_RS07565 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HRE60_RS07585 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HRE60_RS07595 ENOG4105W1Y Transcriptional regulator HRE60_RS07610 ENOG4105VG1 fes assembly suf system protein HRE60_RS07620 ENOG4105CBX hi0933 family HRE60_RS07650 ENOG4105K59 histidine triad (HIT) protein HRE60_RS07680 ENOG4105DXX methyltransferase HRE60_RS07685 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HRE60_RS07690 ENOG4108WF2 Metal Dependent Phosphohydrolase HRE60_RS07695 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HRE60_RS07700 ENOG410812S Rna-binding protein HRE60_RS07705 ENOG4105CQW ribosome biogenesis GTPase YqeH HRE60_RS07710 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HRE60_RS07715 ENOG4108UZ3 Transporter HRE60_RS07725 ENOG4105CK1 PTS System HRE60_RS07735 ENOG4105VCP PTS System HRE60_RS07740 ENOG4105EMD TRANSCRIPTIONal HRE60_RS07750 ENOG4105W3H MtN3 and saliva related transmembrane protein HRE60_RS07755 ENOG4105CS2 ec 3.2.1.21 HRE60_RS07780 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HRE60_RS07800 ENOG4105CS2 ec 3.2.1.21 HRE60_RS07815 ENOG4105CHM Aminotransferase HRE60_RS07820 ENOG4107YZX Universal stress protein HRE60_RS07830 ENOG4105F1A Pyruvate formate-lyase HRE60_RS07840 ENOG4105C37 (CBS) domain HRE60_RS07845 ENOG4105DKW ABC transporter HRE60_RS07860 ENOG4105EEQ Na H antiporter HRE60_RS07875 ENOG4105N5T Radical SAM Protein HRE60_RS07880 ENOG41063PX domain protein HRE60_RS07885 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HRE60_RS07890 ENOG4106H78 methyltransferase HRE60_RS07895 ENOG4105C3M thioredoxin reductase HRE60_RS07905 ENOG4105CDA abc transporter atp-binding protein HRE60_RS07915 ENOG4105EAB amino acid AbC transporter HRE60_RS07930 ENOG4105C6N Formate acetyltransferase HRE60_RS07955 ENOG4107S1E Beta-lactamase HRE60_RS07970 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRE60_RS07990 ENOG4105BZ1 (ABC) transporter HRE60_RS07995 ENOG4105BZ1 (ABC) transporter HRE60_RS08015 ENOG4105MMD transcriptional regulator HRE60_RS08020 ENOG4107R8B 5'-nucleotidase HRE60_RS08030 ENOG4105C1J atp-dependent rna helicase HRE60_RS08040 ENOG4105CJN penicillin-binding protein HRE60_RS08065 ENOG4105KAF membrAne HRE60_RS08075 ENOG4105KAF membrAne HRE60_RS08080 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HRE60_RS08085 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HRE60_RS08095 ENOG4108IUX (ABC) transporter HRE60_RS08100 ENOG4108UQV Membrane HRE60_RS08140 ENOG4108IY8 ABC, transporter HRE60_RS08175 ENOG4108X4Q Hydrolase HRE60_RS08180 ENOG4107RB3 L-asparaginase HRE60_RS08190 ENOG4105VMP Transcriptional regulator HRE60_RS08210 ENOG4105CB5 ATP-dependent DNA helicase recG HRE60_RS08225 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRE60_RS08230 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRE60_RS08235 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HRE60_RS08245 ENOG4105DG6 mannose-6-phosphate isomerase HRE60_RS08250 ENOG4105EVU fructokinase HRE60_RS08255 ENOG4105C5Y PTS System HRE60_RS08265 ENOG4105ETE Transcriptional regulator (LacI family HRE60_RS08280 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRE60_RS08285 ENOG4108UK2 deaminase HRE60_RS08290 ENOG4105DC7 peptidase M24 HRE60_RS08300 ENOG4105DA5 (ABC) transporter HRE60_RS08325 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HRE60_RS08375 ENOG4105C2M dna polymerase I HRE60_RS08400 ENOG4105C3F Signal peptidase i HRE60_RS08405 ENOG4105C7H Helicase, RecD TraA family HRE60_RS08415 ENOG4108UMN azlc family HRE60_RS08425 ENOG410801F ribosomal-protein-alanine acetyltransferase HRE60_RS08430 ENOG41072GX Peptidase M22 Glycoprotease HRE60_RS08445 ENOG41068JE domain protein HRE60_RS08450 ENOG4105C5F glutamine synthetase HRE60_RS08455 ENOG4105KV4 Transcriptional regulator HRE60_RS08465 ENOG4105BZA Phosphoglycerate kinase HRE60_RS08475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HRE60_RS08495 ENOG4105DFT pur operon repressor HRE60_RS08515 ENOG4105DJV ribulose-phosphate 3-epimerase HRE60_RS08540 ENOG4105F8V Hydrolase, tatD family HRE60_RS08545 ENOG4105K4P CoA-binding domain protein HRE60_RS08550 ENOG4105K63 Thioredoxin HRE60_RS08675 ENOG4105DYS nad(p)h dehydrogenase (quinone) HRE60_RS08680 ENOG4108IG5 Transcriptional regulator HRE60_RS08740 ENOG4105DIB Oligopeptide-binding protein HRE60_RS08780 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HRE60_RS08790 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HRE60_RS08810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRE60_RS08815 ENOG4107ZXI Rhomboid family HRE60_RS08820 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HRE60_RS08835 ENOG4105D4U had-superfamily hydrolase, subfamily iia HRE60_RS08880 ENOG4108VDD TRNA binding domain protein HRE60_RS08900 ENOG4105CN9 Peptidase m42 family protein HRE60_RS08905 ENOG4105II7 pyrroline-5-carboxylate reductase HRE60_RS08910 ENOG4108TYN CAAX amino terminal protease family protein HRE60_RS08925 ENOG41067QW Transcriptional regulator HRE60_RS08990 ENOG4105BZ4 penicillin-binding protein HRE60_RS09005 ENOG4108ZP8 Acetolactate synthase small subunit HRE60_RS09015 ENOG4105C01 Dihydroxy-acid dehydratase HRE60_RS09020 ENOG4105DP4 dak2 domain fusion protein ylov HRE60_RS09030 ENOG4105UQX Mate efflux family protein HRE60_RS09035 ENOG4105D98 threonine synthase HRE60_RS09050 ENOG4105C0A alcohol dehydrogenase HRE60_RS09055 ENOG4105C9K Endothelin-converting enzyme 1 HRE60_RS09060 ENOG4105CG3 alpha amylase, catalytic region HRE60_RS09065 ENOG4105C5Y PTS System HRE60_RS09070 ENOG4107414 GntR family transcriptional regulator HRE60_RS09075 ENOG4108UIC UPF0340 protein HRE60_RS09140 ENOG41067QW Transcriptional regulator HRE60_RS09155 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR HRE60_RS09175 ENOG4106BHR ftsk SpoIIIE family protein HRE60_RS09185 ENOG4105DA5 (ABC) transporter HRE60_RS09190 ENOG41069JR HRE60_RS09215 ENOG4108FPN Integrase HRE60_RS09265 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase HRE60_RS09280 ENOG4105D2N Aldolase HRE60_RS09330 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HRE60_RS09365 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HRE60_RS09435 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HRE60_RS09445 ENOG4105EXC Acyl-transferase HRE60_RS09455 ENOG4105KJF protein tyrosine phosphatase HRE60_RS09475 ENOG41067QW Transcriptional regulator HRE60_RS09505 ENOG4105D1H recombination factor protein RarA HRE60_RS09510 ENOG4105VB9 50S ribosomal protein l28 HRE60_RS09535 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HRE60_RS09545 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HRE60_RS09555 ENOG4107AYK membrAne HRE60_RS09575 ENOG4105C5Y PTS System HRE60_RS09615 ENOG4105BZU Histidine kinase HRE60_RS09620 ENOG4105CKK Glycosyl transferase, family 2 HRE60_RS09645 ENOG4105M6F mutator MutT protein HRE60_RS09665 ENOG4105ECB domain protein HRE60_RS09665 ENOG4105ECB domain protein HRE60_RS09675 ENOG4105KA3 membrAne HRE60_RS09685 ENOG4108RS6 transposase HRE60_RS09700 ENOG4105CDU Replicative dna helicase HRE60_RS09720 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HRE60_RS09735 ENOG4106770 Is able to cleave peptidoglycan (By similarity) HRE60_RS09740 ENOG41069ER domain protein HRE60_RS09745 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HRE60_RS09760 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HRE60_RS09800 ENOG4108JYZ YitT family HRE60_RS09805 ENOG4105C5H ABC transporter HRE60_RS09840 ENOG4105C0H protease HRE60_RS09845 ENOG4105FA0 parb-like partition protein HRE60_RS09890 ENOG4107J0C type IIi HRE60_RS09895 ENOG4107QMH DNA methylase HRE60_RS10090 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HRE60_RS10165 ENOG4108M15 ABC transporter HRE60_RS10270 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HRE60_RS10310 ENOG4106HDD HRE60_RS10325 ENOG4105C0D helicase HRE60_RS10355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HRE60_RS10360 ENOG4108IMY Transcriptional regulator HRE60_RS10400 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HRE60_RS10415 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRE60_RS10490 ENOG4105W5Q DNA repair protein (RadC HRE60_RS10585 ENOG4108UUM single-stranded DNA-binding protein HRE60_RS10695 ENOG4105CNU cell division protein FtsK HRE60_RS10725 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)