locus-tag	class	description
HRE60_RS00010	COG0592	DNA-directed DNA polymerase activity
HRE60_RS00020	COG0012	GTP binding
HRE60_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRE60_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HRE60_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE60_RS00195	COG0436	Aminotransferase
HRE60_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE60_RS00220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRE60_RS00230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRE60_RS00235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRE60_RS00250	COG0151	Belongs to the GarS family
HRE60_RS00255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRE60_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRE60_RS00290	COG4550	Control of competence regulator ComK, YlbF/YmcA
HRE60_RS00330	COG2818	Glycosylase
HRE60_RS00345	COG1393	Belongs to the ArsC family
HRE60_RS00430	COG2176	DNA-directed DNA polymerase activity
HRE60_RS00435	COG2309	aminopeptidase activity
HRE60_RS00445	COG1846	Transcriptional regulator
HRE60_RS00460	COG3634	alkyl hydroperoxide reductase activity
HRE60_RS00465	COG0450	alkyl hydroperoxide reductase
HRE60_RS00485	COG4463	regulation of RNA biosynthetic process
HRE60_RS00490	COG0542	response to heat
HRE60_RS00495	COG1686	Belongs to the peptidase S11 family
HRE60_RS00500	COG1686	Belongs to the peptidase S11 family
HRE60_RS00515	COG1045	serine acetyltransferase
HRE60_RS00525	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HRE60_RS00535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRE60_RS00540	COG3688	RNA-binding protein containing a PIN domain
HRE60_RS00555	COG1476	TRANSCRIPTIONal
HRE60_RS00560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRE60_RS00585	COG1674	ftsk spoiiie
HRE60_RS00620	COG4509	Sortase family
HRE60_RS00630	COG3830	Belongs to the UPF0237 family
HRE60_RS00640	COG0588	phosphoglycerate mutase activity
HRE60_RS00645	COG1876	peptidase activity
HRE60_RS00660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE60_RS00685	COG0351	phosphomethylpyrimidine kinase
HRE60_RS00725	COG0668	transmembrane transport
HRE60_RS00740	COG0504	CTP synthase activity
HRE60_RS00750	COG0494	nUDIX hydrolase
HRE60_RS00760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRE60_RS00765	COG0737	Belongs to the 5'-nucleotidase family
HRE60_RS00790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRE60_RS00825	COG1126	abc transporter atp-binding protein
HRE60_RS00830	COG0765	amino acid transport
HRE60_RS00850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRE60_RS00860	COG0719	Fe-S assembly protein
HRE60_RS00865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRE60_RS00890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRE60_RS00900	COG1121	(ABC) transporter
HRE60_RS00905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE60_RS00915	COG2190	(PTS) system
HRE60_RS00915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRE60_RS00915	COG1263	PTS System
HRE60_RS00930	COG1396	sequence-specific DNA binding
HRE60_RS00935	COG1132	(ABC) transporter
HRE60_RS00955	COG4589	Belongs to the CDS family
HRE60_RS00970	COG4120	Belongs to the binding-protein-dependent transport system permease family
HRE60_RS00975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRE60_RS00975	COG1116	anion transmembrane transporter activity
HRE60_RS01005	COG0564	pseudouridine synthase activity
HRE60_RS01010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRE60_RS01035	COG0561	phosphatase activity
HRE60_RS01040	COG1349	DNA-binding transcription factor activity
HRE60_RS01075	COG3279	Response regulator of the LytR AlgR family
HRE60_RS01090	COG0577	efflux transmembrane transporter activity
HRE60_RS01090	COG1136	(ABC) transporter
HRE60_RS01095	COG0577	efflux transmembrane transporter activity
HRE60_RS01095	COG1136	(ABC) transporter
HRE60_RS01100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRE60_RS01115	COG3579	cysteine-type endopeptidase activity
HRE60_RS01120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRE60_RS01145	COG0116	Belongs to the methyltransferase superfamily
HRE60_RS01155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE60_RS01175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRE60_RS01195	COG1254	Belongs to the acylphosphatase family
HRE60_RS01200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRE60_RS01225	COG1309	transcriptional regulator
HRE60_RS01240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRE60_RS01260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRE60_RS01265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRE60_RS01270	COG1187	pseudouridine synthase activity
HRE60_RS01280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRE60_RS01285	COG0569	domain protein
HRE60_RS01295	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HRE60_RS01300	COG0671	phosphoesterase, PA-phosphatase related
HRE60_RS01310	COG2274	protein secretion by the type I secretion system
HRE60_RS01325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS01330	COG1464	Belongs to the NlpA lipoprotein family
HRE60_RS01340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRE60_RS01350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRE60_RS01365	COG1122	ATPase activity
HRE60_RS01380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRE60_RS01395	COG0745	RESPONSE REGULATOR receiver
HRE60_RS01400	COG5002	protein histidine kinase activity
HRE60_RS01415	COG1484	DNA-dependent DNA replication
HRE60_RS01440	COG3716	PTS system mannose fructose sorbose family IID component
HRE60_RS01445	COG3715	PTS system
HRE60_RS01460	COG3716	PTS system mannose fructose sorbose family IID component
HRE60_RS01465	COG3715	PTS system
HRE60_RS01475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HRE60_RS01480	COG0561	phosphatase activity
HRE60_RS01485	COG2252	PERMEase
HRE60_RS01490	COG0802	atpase or kinase
HRE60_RS01495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRE60_RS01500	COG1316	TRANSCRIPTIONal
HRE60_RS01510	COG0195	Participates in both transcription termination and antitermination
HRE60_RS01515	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HRE60_RS01525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRE60_RS01545	COG2244	polysaccharide biosynthetic process
HRE60_RS01550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRE60_RS01555	COG0626	cystathionine gamma-synthase activity
HRE60_RS01560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRE60_RS01590	COG4471	UPF0298 protein
HRE60_RS01620	COG0517	IMP dehydrogenase activity
HRE60_RS01630	COG1739	Uncharacterized protein family UPF0029
HRE60_RS01635	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HRE60_RS01730	COG0527	aspartate kinase activity
HRE60_RS01735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE60_RS01740	COG1024	Enoyl-CoA hydratase
HRE60_RS01745	COG1846	Transcriptional regulator
HRE60_RS01765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRE60_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
HRE60_RS01775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRE60_RS01790	COG0439	Biotin carboxylase
HRE60_RS01815	COG1349	DNA-binding transcription factor activity
HRE60_RS01820	COG1105	Belongs to the carbohydrate kinase PfkB family
HRE60_RS01825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRE60_RS01825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRE60_RS01825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRE60_RS01830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE60_RS01835	COG0285	dihydrofolate synthase activity
HRE60_RS01845	COG1104	cysteine desulfurase activity
HRE60_RS01850	COG0301	tRNA thio-modification
HRE60_RS01905	COG0488	(ABC) transporter
HRE60_RS01925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRE60_RS01935	COG0242	peptide deformylase activity
HRE60_RS01960	COG2357	RelA SpoT domain protein
HRE60_RS01965	COG0745	RESPONSE REGULATOR receiver
HRE60_RS02000	COG1702	phosphate starvation-inducible protein PhoH
HRE60_RS02020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE60_RS02020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE60_RS02025	COG0656	L-ascorbic acid biosynthetic process
HRE60_RS02030	COG0583	DNA-binding transcription factor activity
HRE60_RS02055	COG2223	nitrite transmembrane transporter activity
HRE60_RS02060	COG4122	O-methyltransferase activity
HRE60_RS02065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRE60_RS02105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRE60_RS02110	COG0436	Aminotransferase
HRE60_RS02125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRE60_RS02130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRE60_RS02135	COG0726	polysaccharide deacetylase
HRE60_RS02150	COG2962	Rard protein
HRE60_RS02170	COG0519	Catalyzes the synthesis of GMP from XMP
HRE60_RS02200	COG0356	it plays a direct role in the translocation of protons across the membrane
HRE60_RS02235	COG0772	Belongs to the SEDS family
HRE60_RS02245	COG0149	triose-phosphate isomerase activity
HRE60_RS02265	COG0470	DNA polymerase III
HRE60_RS02270	COG1774	PSP1 C-terminal conserved region
HRE60_RS02275	COG4467	Involved in initiation control of chromosome replication
HRE60_RS02285	COG0004	ammonium transporteR
HRE60_RS02290	COG0347	Belongs to the P(II) protein family
HRE60_RS02295	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRE60_RS02295	COG1388	LysM domain
HRE60_RS02315	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRE60_RS02345	COG1113	amino acid transport
HRE60_RS02355	COG2190	(PTS) system
HRE60_RS02355	COG1263	PTS System
HRE60_RS02355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRE60_RS02405	COG0564	pseudouridine synthase activity
HRE60_RS02425	COG0505	Belongs to the CarA family
HRE60_RS02445	COG1136	(ABC) transporter
HRE60_RS02450	COG0577	efflux transmembrane transporter activity
HRE60_RS02470	COG1132	(ABC) transporter
HRE60_RS02510	COG1187	pseudouridine synthase activity
HRE60_RS02515	COG1473	amidohydrolase
HRE60_RS02520	COG0686	Belongs to the AlaDH PNT family
HRE60_RS02530	COG2267	carboxylic ester hydrolase activity
HRE60_RS02535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE60_RS02560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRE60_RS02595	COG0438	transferase activity, transferring glycosyl groups
HRE60_RS02610	COG0596	Alpha beta hydrolase
HRE60_RS02625	COG1272	protein, Hemolysin III
HRE60_RS02640	COG3425	synthase
HRE60_RS02650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRE60_RS02670	COG0833	amino acid
HRE60_RS02675	COG2040	homocysteine
HRE60_RS02695	COG0187	DNA topoisomerase II activity
HRE60_RS02715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE60_RS02735	COG0539	negative regulation of cytoplasmic translation
HRE60_RS02775	COG0494	nUDIX hydrolase
HRE60_RS02780	COG0542	response to heat
HRE60_RS02785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRE60_RS02790	COG4703	Protein of unknown function (DUF1797)
HRE60_RS02800	COG1126	abc transporter atp-binding protein
HRE60_RS02830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRE60_RS02835	COG0768	penicillin binding
HRE60_RS02840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRE60_RS02855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRE60_RS02860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRE60_RS02865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRE60_RS02870	COG0237	dephospho-CoA kinase activity
HRE60_RS02875	COG2814	Major facilitator Superfamily
HRE60_RS02890	COG0557	exoribonuclease II activity
HRE60_RS02905	COG1185	polyribonucleotide nucleotidyltransferase activity
HRE60_RS02910	COG0006	proline dipeptidase activity
HRE60_RS02915	COG1609	Transcriptional regulator
HRE60_RS02945	COG1368	sulfuric ester hydrolase activity
HRE60_RS02950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRE60_RS02975	COG0287	Prephenate dehydrogenase
HRE60_RS02990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRE60_RS03000	COG0077	Prephenate dehydratase
HRE60_RS03055	COG3708	Transcriptional regulator
HRE60_RS03055	COG2207	Transcriptional regulator
HRE60_RS03060	COG0454	-acetyltransferase
HRE60_RS03080	COG1131	(ABC) transporter
HRE60_RS03115	COG2807	transmembrane transport
HRE60_RS03130	COG1418	mRNA catabolic process
HRE60_RS03155	COG0477	Major facilitator Superfamily
HRE60_RS03180	COG1120	ATPase activity
HRE60_RS03190	COG2819	hydrolase of the alpha beta superfamily
HRE60_RS03195	COG1597	lipid kinase activity
HRE60_RS03205	COG2261	transglycosylase associated protein
HRE60_RS03210	COG3237	CsbD-like
HRE60_RS03215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE60_RS03220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRE60_RS03225	COG0022	dehydrogenase e1 component
HRE60_RS03230	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRE60_RS03290	COG0659	secondary active sulfate transmembrane transporter activity
HRE60_RS03295	COG3689	TIGRFAM TIGR03943 family protein
HRE60_RS03300	COG0701	Predicted permease
HRE60_RS03305	COG2183	response to ionizing radiation
HRE60_RS03325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRE60_RS03360	COG1268	BioY protein
HRE60_RS03370	COG4443	Transcriptional Coactivator p15 (PC4)
HRE60_RS03375	COG1914	H( )-stimulated, divalent metal cation uptake system
HRE60_RS03385	COG0494	nUDIX hydrolase
HRE60_RS03405	COG1388	LysM domain
HRE60_RS03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRE60_RS03420	COG0588	phosphoglycerate mutase activity
HRE60_RS03425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRE60_RS03440	COG0561	phosphatase activity
HRE60_RS03455	COG4221	oxidoreductase activity
HRE60_RS03460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRE60_RS03510	COG1704	LemA family
HRE60_RS03515	COG0501	Belongs to the peptidase M48B family
HRE60_RS03550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRE60_RS03560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRE60_RS03570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRE60_RS03575	COG0783	Belongs to the Dps family
HRE60_RS03580	COG0735	belongs to the Fur family
HRE60_RS03585	COG4483	Protein conserved in bacteria
HRE60_RS03590	COG1940	carbohydrate kinase activity
HRE60_RS03620	COG0849	cell division
HRE60_RS03630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRE60_RS03640	COG0762	integral membrane protein
HRE60_RS03650	COG3599	regulation of cell shape
HRE60_RS03660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRE60_RS03665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRE60_RS03670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE60_RS03675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRE60_RS03680	COG0372	Belongs to the citrate synthase family
HRE60_RS03720	COG0513	Belongs to the DEAD box helicase family
HRE60_RS03730	COG0488	(ABC) transporter
HRE60_RS03745	COG0392	lysyltransferase activity
HRE60_RS03745	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HRE60_RS03750	COG3442	glutamine amidotransferase
HRE60_RS03755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRE60_RS03780	COG2384	SAM-dependent methyltransferase
HRE60_RS03795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRE60_RS03805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRE60_RS03815	COG1088	dTDP-glucose 4,6-dehydratase activity
HRE60_RS03830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRE60_RS03840	COG0647	UMP catabolic process
HRE60_RS03880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRE60_RS03890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRE60_RS03900	COG0107	imidazoleglycerol-phosphate synthase activity
HRE60_RS03940	COG5263	repeat protein
HRE60_RS03940	COG0366	Alpha amylase catalytic
HRE60_RS03945	COG0366	Alpha amylase catalytic
HRE60_RS03945	COG5263	repeat protein
HRE60_RS03950	COG5263	repeat protein
HRE60_RS03950	COG0366	Alpha amylase catalytic
HRE60_RS03955	COG0772	Belongs to the SEDS family
HRE60_RS03960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRE60_RS03975	COG0300	oxidoreductase activity
HRE60_RS03985	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRE60_RS03985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRE60_RS04005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRE60_RS04030	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HRE60_RS04035	COG1438	arginine binding
HRE60_RS04040	COG0497	DNA recombination
HRE60_RS04050	COG2755	lipolytic protein G-D-S-L family
HRE60_RS04060	COG0776	regulation of translation
HRE60_RS04070	COG0167	dihydroorotate dehydrogenase activity
HRE60_RS04075	COG0588	phosphoglycerate mutase activity
HRE60_RS04095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRE60_RS04100	COG0066	3-isopropylmalate dehydratase activity
HRE60_RS04115	COG0469	pyruvate kinase activity
HRE60_RS04140	COG3842	ATPase activity
HRE60_RS04165	COG0716	FMN binding
HRE60_RS04180	COG0038	chloride channel
HRE60_RS04185	COG0335	large ribosomal subunit rRNA binding
HRE60_RS04205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRE60_RS04210	COG1956	GAF domain-containing protein
HRE60_RS04215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRE60_RS04225	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRE60_RS04225	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRE60_RS04280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE60_RS04305	COG0765	amino acid transport
HRE60_RS04310	COG0765	amino acid transport
HRE60_RS04315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS04320	COG1126	abc transporter atp-binding protein
HRE60_RS04325	COG0765	amino acid transport
HRE60_RS04330	COG0765	amino acid transport
HRE60_RS04335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS04340	COG1126	abc transporter atp-binding protein
HRE60_RS04345	COG0745	RESPONSE REGULATOR receiver
HRE60_RS04350	COG5002	protein histidine kinase activity
HRE60_RS04355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRE60_RS04360	COG2832	Protein of unknown function (DUF454)
HRE60_RS04390	COG0778	Nitroreductase
HRE60_RS04400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRE60_RS04410	COG2884	Cell division ATP-binding protein ftsE
HRE60_RS04415	COG2177	Part of the ABC transporter FtsEX involved in
HRE60_RS04420	COG1051	belongs to the nudix hydrolase family
HRE60_RS04425	COG0628	permease
HRE60_RS04440	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRE60_RS04470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRE60_RS04475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRE60_RS04525	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRE60_RS04535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRE60_RS04550	COG0813	purine-nucleoside phosphorylase activity
HRE60_RS04555	COG1316	TRANSCRIPTIONal
HRE60_RS04585	COG0297	glycogen (starch) synthase activity
HRE60_RS04595	COG1442	glycosyl transferase family 8
HRE60_RS04595	COG1216	Glycosyl transferase, family 2
HRE60_RS04600	COG1442	glycosyl transferase family 8
HRE60_RS04600	COG1216	Glycosyl transferase, family 2
HRE60_RS04615	COG0562	UDP-galactopyranose mutase
HRE60_RS04625	COG0438	transferase activity, transferring glycosyl groups
HRE60_RS04635	COG0561	phosphatase activity
HRE60_RS04650	COG0588	phosphoglycerate mutase activity
HRE60_RS04655	COG0628	permease
HRE60_RS04680	COG4667	esterase of the alpha-beta hydrolase superfamily
HRE60_RS04695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRE60_RS04725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRE60_RS04730	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRE60_RS04730	COG0022	dehydrogenase e1 component
HRE60_RS04735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRE60_RS04740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE60_RS04750	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRE60_RS04755	COG1523	belongs to the glycosyl hydrolase 13 family
HRE60_RS04760	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRE60_RS04765	COG4605	iron ion homeostasis
HRE60_RS04770	COG4604	ABC transporter, ATP-binding protein
HRE60_RS04775	COG4607	ABC-type enterochelin transport system periplasmic component
HRE60_RS04780	COG2822	iron ion transport
HRE60_RS04785	COG2837	iron assimilation
HRE60_RS04790	COG0672	)-iron permease
HRE60_RS04795	COG0805	protein transport
HRE60_RS04800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRE60_RS04810	COG3842	ATPase activity
HRE60_RS04815	COG3833	ABC-type maltose transport systems, permease component
HRE60_RS04820	COG1175	transmembrane transport
HRE60_RS04830	COG1609	Transcriptional regulator
HRE60_RS04835	COG1640	4-alpha-glucanotransferase
HRE60_RS04840	COG0058	SHG alpha-glucan phosphorylase activity
HRE60_RS04850	COG0095	Lipoate-protein ligase
HRE60_RS04865	COG0704	Plays a role in the regulation of phosphate uptake
HRE60_RS04880	COG0581	inorganic phosphate transmembrane transporter activity
HRE60_RS04885	COG0573	inorganic phosphate transmembrane transporter activity
HRE60_RS04895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRE60_RS04895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HRE60_RS04900	COG0483	inositol monophosphate 1-phosphatase activity
HRE60_RS04910	COG1393	Belongs to the ArsC family
HRE60_RS04915	COG0196	riboflavin kinase activity
HRE60_RS04920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRE60_RS04950	COG2873	o-acetylhomoserine
HRE60_RS04955	COG0210	DNA helicase
HRE60_RS04960	COG1115	amino acid carrier protein
HRE60_RS04970	COG1917	Cupin 2, conserved barrel domain protein
HRE60_RS04970	COG2207	Transcriptional regulator
HRE60_RS04975	COG0737	Belongs to the 5'-nucleotidase family
HRE60_RS04980	COG0765	amino acid transport
HRE60_RS04985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS05000	COG0284	orotidine-5'-phosphate decarboxylase activity
HRE60_RS05015	COG0167	dihydroorotate dehydrogenase activity
HRE60_RS05035	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HRE60_RS05045	COG0534	Mate efflux family protein
HRE60_RS05050	COG4607	ABC-type enterochelin transport system periplasmic component
HRE60_RS05060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE60_RS05080	COG1063	alcohol dehydrogenase
HRE60_RS05090	COG1230	cation diffusion facilitator family transporter
HRE60_RS05115	COG3201	nicotinamide mononucleotide transporter
HRE60_RS05130	COG0577	efflux transmembrane transporter activity
HRE60_RS05130	COG1136	(ABC) transporter
HRE60_RS05150	COG1174	glycine betaine transport
HRE60_RS05160	COG0604	alcohol dehydrogenase
HRE60_RS05170	COG1846	Transcriptional regulator
HRE60_RS05175	COG3527	Alpha-acetolactate decarboxylase
HRE60_RS05180	COG0028	Belongs to the TPP enzyme family
HRE60_RS05220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRE60_RS05245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRE60_RS05250	COG0758	DNA mediated transformation
HRE60_RS05265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HRE60_RS05275	COG1827	regulation of RNA biosynthetic process
HRE60_RS05285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRE60_RS05295	COG2188	Transcriptional regulator
HRE60_RS05300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRE60_RS05300	COG0519	Catalyzes the synthesis of GMP from XMP
HRE60_RS05310	COG1064	alcohol dehydrogenase
HRE60_RS05325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRE60_RS05330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS05335	COG1126	abc transporter atp-binding protein
HRE60_RS05340	COG0765	amino acid transport
HRE60_RS05345	COG2824	Alkylphosphonate utilization operon protein PhnA
HRE60_RS05350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRE60_RS05355	COG0583	DNA-binding transcription factor activity
HRE60_RS05360	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRE60_RS05360	COG3942	CHAP domain
HRE60_RS05380	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRE60_RS05380	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRE60_RS05430	COG0720	synthase
HRE60_RS05440	COG0251	oxidation-reduction process
HRE60_RS05450	COG0017	Asparaginyl-tRNA synthetase
HRE60_RS05455	COG0436	Aminotransferase
HRE60_RS05465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRE60_RS05465	COG1199	ATP-dependent helicase activity
HRE60_RS05490	COG1744	ABC transporter substrate-binding protein PnrA-like
HRE60_RS05495	COG0295	cytidine deaminase activity
HRE60_RS05500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRE60_RS05505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRE60_RS05510	COG2813	Specifically methylates the guanine in position
HRE60_RS05525	COG5002	protein histidine kinase activity
HRE60_RS05530	COG0745	RESPONSE REGULATOR receiver
HRE60_RS05545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRE60_RS05550	COG4684	Psort location CytoplasmicMembrane, score
HRE60_RS05555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRE60_RS05575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRE60_RS05580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRE60_RS05585	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HRE60_RS05595	COG1696	Membrane protein involved in D-alanine export
HRE60_RS05610	COG1132	(ABC) transporter
HRE60_RS05635	COG0009	L-threonylcarbamoyladenylate synthase
HRE60_RS05640	COG2890	protein-(glutamine-N5) methyltransferase activity
HRE60_RS05650	COG1435	thymidine kinase activity
HRE60_RS05655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRE60_RS05660	COG0625	glutathione transferase activity
HRE60_RS05665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRE60_RS05690	COG0346	lactoylglutathione lyase activity
HRE60_RS05695	COG3764	Sortase (surface protein transpeptidase)
HRE60_RS05715	COG0488	(ABC) transporter
HRE60_RS05740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRE60_RS05750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRE60_RS05750	COG1328	CTP reductase activity
HRE60_RS05785	COG1196	nuclear chromosome segregation
HRE60_RS05800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRE60_RS05810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRE60_RS05820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRE60_RS05825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRE60_RS05830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRE60_RS05845	COG1011	Hydrolase
HRE60_RS05850	COG1760	l-serine dehydratase
HRE60_RS05855	COG1760	l-serine dehydratase
HRE60_RS05860	COG1621	beta-fructofuranosidase activity
HRE60_RS05860	COG3583	domain protein
HRE60_RS05860	COG5492	domain, Protein
HRE60_RS05865	COG0697	spore germination
HRE60_RS05905	COG2197	response regulator
HRE60_RS05910	COG4585	Histidine kinase
HRE60_RS05920	COG1131	(ABC) transporter
HRE60_RS05935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRE60_RS05945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE60_RS05950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE60_RS05975	COG1819	glycosyl
HRE60_RS05985	COG0484	heat shock protein binding
HRE60_RS05990	COG0443	Heat shock 70 kDa protein
HRE60_RS05995	COG0385	Bile acid
HRE60_RS06010	COG1131	(ABC) transporter
HRE60_RS06030	COG0577	efflux transmembrane transporter activity
HRE60_RS06035	COG1136	(ABC) transporter
HRE60_RS06045	COG0745	RESPONSE REGULATOR receiver
HRE60_RS06055	COG2233	PERMEase
HRE60_RS06065	COG3842	ATPase activity
HRE60_RS06075	COG0534	Mate efflux family protein
HRE60_RS06080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRE60_RS06080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRE60_RS06085	COG1114	Component of the transport system for branched-chain amino acids
HRE60_RS06090	COG1482	cell wall glycoprotein biosynthetic process
HRE60_RS06120	COG0531	amino acid
HRE60_RS06125	COG5263	repeat protein
HRE60_RS06125	COG0366	Alpha amylase catalytic
HRE60_RS06135	COG0386	Belongs to the glutathione peroxidase family
HRE60_RS06160	COG4989	oxidoreductase activity
HRE60_RS06170	COG2514	catechol 2,3-dioxygenase activity
HRE60_RS06175	COG1959	2 iron, 2 sulfur cluster binding
HRE60_RS06185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRE60_RS06190	COG0778	Nitroreductase
HRE60_RS06200	COG0656	L-ascorbic acid biosynthetic process
HRE60_RS06205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE60_RS06220	COG1609	Transcriptional regulator
HRE60_RS06225	COG0366	Alpha amylase catalytic
HRE60_RS06230	COG0366	Alpha amylase catalytic
HRE60_RS06235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRE60_RS06240	COG3842	ATPase activity
HRE60_RS06245	COG0395	ABC-type sugar transport system, permease component
HRE60_RS06250	COG1175	transmembrane transport
HRE60_RS06255	COG1653	transport
HRE60_RS06260	COG3345	alpha-galactosidase
HRE60_RS06265	COG2207	Transcriptional regulator
HRE60_RS06270	COG0366	Alpha amylase catalytic
HRE60_RS06275	COG5002	protein histidine kinase activity
HRE60_RS06280	COG0745	RESPONSE REGULATOR receiver
HRE60_RS06285	COG0577	efflux transmembrane transporter activity
HRE60_RS06290	COG1136	(ABC) transporter
HRE60_RS06320	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HRE60_RS06325	COG1461	Dihydroxyacetone kinase
HRE60_RS06330	COG2376	Dihydroxyacetone kinase
HRE60_RS06350	COG3590	peptidase
HRE60_RS06385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRE60_RS06400	COG0366	Alpha amylase catalytic
HRE60_RS06400	COG5263	repeat protein
HRE60_RS06405	COG0366	Alpha amylase catalytic
HRE60_RS06405	COG5263	repeat protein
HRE60_RS06410	COG0366	Alpha amylase catalytic
HRE60_RS06410	COG5263	repeat protein
HRE60_RS06430	COG5263	repeat protein
HRE60_RS06430	COG0366	Alpha amylase catalytic
HRE60_RS06435	COG5263	repeat protein
HRE60_RS06435	COG0366	Alpha amylase catalytic
HRE60_RS06435	COG5263	repeat protein
HRE60_RS06435	COG0366	Alpha amylase catalytic
HRE60_RS06440	COG0366	Alpha amylase catalytic
HRE60_RS06440	COG5263	repeat protein
HRE60_RS06490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HRE60_RS06490	COG0392	lysyltransferase activity
HRE60_RS06495	COG0679	Auxin Efflux Carrier
HRE60_RS06500	COG0281	malic enzyme
HRE60_RS06510	COG0583	DNA-binding transcription factor activity
HRE60_RS06520	COG0477	Major facilitator Superfamily
HRE60_RS06530	COG0110	maltose O-acetyltransferase activity
HRE60_RS06535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HRE60_RS06545	COG5263	repeat protein
HRE60_RS06545	COG0366	Alpha amylase catalytic
HRE60_RS06595	COG0653	protein targeting
HRE60_RS06620	COG1216	Glycosyl transferase, family 2
HRE60_RS06620	COG1442	glycosyl transferase family 8
HRE60_RS06625	COG0419	ATPase involved in DNA repair
HRE60_RS06630	COG0420	3'-5' exonuclease activity
HRE60_RS06640	COG3064	Membrane
HRE60_RS06685	COG0488	(ABC) transporter
HRE60_RS06690	COG1132	(ABC) transporter
HRE60_RS06695	COG1132	(ABC) transporter
HRE60_RS06720	COG0058	SHG alpha-glucan phosphorylase activity
HRE60_RS06725	COG0297	glycogen (starch) synthase activity
HRE60_RS06730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRE60_RS06735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRE60_RS06740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRE60_RS06745	COG1523	belongs to the glycosyl hydrolase 13 family
HRE60_RS06780	COG2197	response regulator
HRE60_RS06785	COG4585	Histidine kinase
HRE60_RS06795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRE60_RS06800	COG0515	serine threonine protein kinase
HRE60_RS06800	COG2815	serine threonine protein kinase
HRE60_RS06810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRE60_RS06810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRE60_RS06820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRE60_RS06835	COG0552	protein localization to endoplasmic reticulum
HRE60_RS06840	COG0561	phosphatase activity
HRE60_RS06845	COG0561	phosphatase activity
HRE60_RS06850	COG1725	Transcriptional regulator
HRE60_RS06855	COG1131	(ABC) transporter
HRE60_RS06865	COG4608	Belongs to the ABC transporter superfamily
HRE60_RS06870	COG0444	Belongs to the ABC transporter superfamily
HRE60_RS06875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRE60_RS06880	COG0601	transmembrane transport
HRE60_RS06885	COG4166	transmembrane transport
HRE60_RS06890	COG4166	transmembrane transport
HRE60_RS06895	COG0280	phosphate acetyltransferase
HRE60_RS06900	COG0564	pseudouridine synthase activity
HRE60_RS06910	COG2357	RelA SpoT domain protein
HRE60_RS06925	COG1104	cysteine desulfurase activity
HRE60_RS06940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRE60_RS06970	COG1215	transferase activity, transferring glycosyl groups
HRE60_RS06985	COG1442	glycosyl transferase family 8
HRE60_RS06985	COG1216	Glycosyl transferase, family 2
HRE60_RS07005	COG1091	dTDP-4-dehydrorhamnose reductase activity
HRE60_RS07010	COG0463	Glycosyl transferase, family 2
HRE60_RS07015	COG2151	metal-sulfur cluster biosynthetic enzyme
HRE60_RS07020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE60_RS07025	COG0358	DNA primase activity
HRE60_RS07030	COG1970	mechanosensitive ion channel activity
HRE60_RS07035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRE60_RS07040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS07045	COG0436	Aminotransferase
HRE60_RS07050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS07055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS07060	COG1051	belongs to the nudix hydrolase family
HRE60_RS07080	COG0765	amino acid transport
HRE60_RS07105	COG1187	pseudouridine synthase activity
HRE60_RS07140	COG0560	Phosphoserine phosphatase
HRE60_RS07150	COG0187	DNA topoisomerase II activity
HRE60_RS07160	COG1346	cytolysis
HRE60_RS07165	COG1380	Effector of murein hydrolase LrgA
HRE60_RS07175	COG1393	Belongs to the ArsC family
HRE60_RS07180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRE60_RS07185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRE60_RS07200	COG1940	carbohydrate kinase activity
HRE60_RS07205	COG0346	lactoylglutathione lyase activity
HRE60_RS07220	COG1177	transmembrane transport
HRE60_RS07225	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRE60_RS07265	COG0531	amino acid
HRE60_RS07270	COG0285	dihydrofolate synthase activity
HRE60_RS07305	COG0500	methyltransferase
HRE60_RS07305	COG3615	Tellurite resistance protein tehB
HRE60_RS07320	COG0708	Exodeoxyribonuclease III
HRE60_RS07345	COG1597	lipid kinase activity
HRE60_RS07355	COG4708	membrane
HRE60_RS07365	COG0024	Methionine aminopeptidase
HRE60_RS07370	COG4109	DRTGG domain
HRE60_RS07375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRE60_RS07380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRE60_RS07385	COG0658	competence protein
HRE60_RS07385	COG2333	competence protein COMEC
HRE60_RS07390	COG1555	photosystem II stabilization
HRE60_RS07390	COG1596	polysaccharide export
HRE60_RS07395	COG0204	Acyl-transferase
HRE60_RS07400	COG0726	polysaccharide deacetylase
HRE60_RS07405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRE60_RS07420	COG0513	Belongs to the DEAD box helicase family
HRE60_RS07440	COG1396	sequence-specific DNA binding
HRE60_RS07445	COG2211	Major facilitator Superfamily
HRE60_RS07460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRE60_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS07485	COG1126	abc transporter atp-binding protein
HRE60_RS07490	COG0765	amino acid transport
HRE60_RS07500	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRE60_RS07510	COG2217	Heavy metal translocating P-type atpase
HRE60_RS07520	COG0159	tryptophan synthase activity
HRE60_RS07525	COG0133	tryptophan synthase activity
HRE60_RS07530	COG0135	phosphoribosylanthranilate isomerase activity
HRE60_RS07545	COG0512	Glutamine amidotransferase of anthranilate synthase
HRE60_RS07550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRE60_RS07555	COG0287	Prephenate dehydrogenase
HRE60_RS07555	COG1605	Chorismate mutase
HRE60_RS07565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRE60_RS07585	COG1136	(ABC) transporter
HRE60_RS07585	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRE60_RS07595	COG0789	Transcriptional regulator
HRE60_RS07610	COG2151	metal-sulfur cluster biosynthetic enzyme
HRE60_RS07620	COG2081	HI0933 family
HRE60_RS07645	COG1131	(ABC) transporter
HRE60_RS07650	COG0537	adenosine 5'-monophosphoramidase activity
HRE60_RS07680	COG2226	methyltransferase
HRE60_RS07685	COG0799	negative regulation of ribosome biogenesis
HRE60_RS07690	COG1713	HD superfamily hydrolase involved in NAD metabolism
HRE60_RS07695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRE60_RS07700	COG1534	Rna-binding protein
HRE60_RS07705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HRE60_RS07710	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HRE60_RS07725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRE60_RS07725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRE60_RS07735	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRE60_RS07740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRE60_RS07740	COG3711	transcriptional antiterminator
HRE60_RS07750	COG4095	Psort location CytoplasmicMembrane, score
HRE60_RS07755	COG2723	6-phospho-beta-galactosidase activity
HRE60_RS07790	COG1442	glycosyl transferase family 8
HRE60_RS07790	COG1216	Glycosyl transferase, family 2
HRE60_RS07795	COG1442	glycosyl transferase family 8
HRE60_RS07800	COG2723	6-phospho-beta-galactosidase activity
HRE60_RS07805	COG1335	isochorismatase
HRE60_RS07815	COG0436	Aminotransferase
HRE60_RS07820	COG0589	response to stress
HRE60_RS07830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRE60_RS07840	COG1253	flavin adenine dinucleotide binding
HRE60_RS07845	COG1119	ATPase activity
HRE60_RS07870	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HRE60_RS07875	COG1242	4 iron, 4 sulfur cluster binding
HRE60_RS07880	COG3480	Lon protease (S16) C-terminal proteolytic domain
HRE60_RS07885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRE60_RS07890	COG0742	ribosomal rna small subunit methyltransferase
HRE60_RS07905	COG1126	abc transporter atp-binding protein
HRE60_RS07910	COG0765	amino acid transport
HRE60_RS07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE60_RS07930	COG1882	Formate acetyltransferase
HRE60_RS07955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRE60_RS07970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRE60_RS07990	COG1132	(ABC) transporter
HRE60_RS07995	COG1132	(ABC) transporter
HRE60_RS08015	COG4470	Protein conserved in bacteria
HRE60_RS08020	COG0737	Belongs to the 5'-nucleotidase family
HRE60_RS08030	COG0513	Belongs to the DEAD box helicase family
HRE60_RS08040	COG0768	penicillin binding
HRE60_RS08065	COG3152	Membrane
HRE60_RS08075	COG3152	Membrane
HRE60_RS08080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRE60_RS08085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRE60_RS08095	COG4152	abc transporter atp-binding protein
HRE60_RS08100	COG1811	Na channel or pump
HRE60_RS08140	COG1116	anion transmembrane transporter activity
HRE60_RS08150	COG0443	Heat shock 70 kDa protein
HRE60_RS08175	COG0561	phosphatase activity
HRE60_RS08180	COG0252	asparaginase activity
HRE60_RS08190	COG3655	Transcriptional regulator
HRE60_RS08210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRE60_RS08225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRE60_RS08230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRE60_RS08235	COG0653	protein targeting
HRE60_RS08245	COG1482	cell wall glycoprotein biosynthetic process
HRE60_RS08250	COG1940	carbohydrate kinase activity
HRE60_RS08255	COG1263	PTS System
HRE60_RS08255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRE60_RS08255	COG2190	(PTS) system
HRE60_RS08260	COG1621	beta-fructofuranosidase activity
HRE60_RS08265	COG1609	Transcriptional regulator
HRE60_RS08280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRE60_RS08285	COG2131	deaminase
HRE60_RS08290	COG0006	proline dipeptidase activity
HRE60_RS08300	COG1131	(ABC) transporter
HRE60_RS08375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRE60_RS08375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRE60_RS08400	COG0681	Belongs to the peptidase S26 family
HRE60_RS08405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE60_RS08415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRE60_RS08425	COG0456	acetyltransferase
HRE60_RS08430	COG1214	PFAM Peptidase M22, glycoprotease
HRE60_RS08445	COG3942	CHAP domain
HRE60_RS08450	COG0174	glutamine synthetase
HRE60_RS08455	COG0789	Transcriptional regulator
HRE60_RS08465	COG0126	phosphoglycerate kinase activity
HRE60_RS08495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRE60_RS08540	COG0084	hydrolase, TatD family'
HRE60_RS08545	COG1832	CoA-binding protein
HRE60_RS08550	COG3118	belongs to the thioredoxin family
HRE60_RS08675	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRE60_RS08690	COG0706	membrane insertase activity
HRE60_RS08740	COG4166	transmembrane transport
HRE60_RS08780	COG0756	dUTP diphosphatase activity
HRE60_RS08790	COG1053	succinate dehydrogenase
HRE60_RS08790	COG3976	FMN-binding domain protein
HRE60_RS08790	COG0431	NADPH-dependent FMN reductase
HRE60_RS08810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRE60_RS08815	COG0457	Tetratricopeptide repeat
HRE60_RS08815	COG0705	Rhomboid family
HRE60_RS08820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRE60_RS08835	COG0647	UMP catabolic process
HRE60_RS08840	COG2226	methyltransferase
HRE60_RS08880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE60_RS08890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRE60_RS08900	COG1363	Peptidase, m42
HRE60_RS08905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRE60_RS08910	COG1266	CAAX protease self-immunity
HRE60_RS08965	COG1459	type II secretion system
HRE60_RS08970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRE60_RS09005	COG0440	acetolactate synthase activity
HRE60_RS09010	COG0028	Belongs to the TPP enzyme family
HRE60_RS09015	COG0129	dihydroxy-acid dehydratase activity
HRE60_RS09020	COG1461	Dihydroxyacetone kinase
HRE60_RS09030	COG0534	Mate efflux family protein
HRE60_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
HRE60_RS09050	COG1454	alcohol dehydrogenase
HRE60_RS09055	COG3590	peptidase
HRE60_RS09060	COG0366	Alpha amylase catalytic
HRE60_RS09065	COG1263	PTS System
HRE60_RS09065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRE60_RS09070	COG2188	Transcriptional regulator
HRE60_RS09075	COG4475	Protein of unknown function (DUF436)
HRE60_RS09140	COG3620	sequence-specific DNA binding
HRE60_RS09155	COG1476	TRANSCRIPTIONal
HRE60_RS09175	COG1674	ftsk spoiiie
HRE60_RS09185	COG1131	(ABC) transporter
HRE60_RS09250	COG0433	COG0433 Predicted ATPase
HRE60_RS09265	COG3942	CHAP domain
HRE60_RS09265	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRE60_RS09275	COG0582	viral genome integration into host DNA
HRE60_RS09330	COG0201	protein transport
HRE60_RS09365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRE60_RS09435	COG0051	transcription antitermination factor activity, RNA binding
HRE60_RS09455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRE60_RS09490	COG0582	viral genome integration into host DNA
HRE60_RS09505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRE60_RS09510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRE60_RS09535	COG1328	CTP reductase activity
HRE60_RS09545	COG0602	queuosine metabolic process
HRE60_RS09555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HRE60_RS09575	COG2190	(PTS) system
HRE60_RS09575	COG1263	PTS System
HRE60_RS09575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRE60_RS09580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRE60_RS09590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRE60_RS09615	COG5001	Diguanylate cyclase
HRE60_RS09615	COG3300	MHYT domain
HRE60_RS09645	COG0494	nUDIX hydrolase
HRE60_RS09650	COG1695	Transcriptional regulator
HRE60_RS09665	COG1511	domain protein
HRE60_RS09665	COG1511	domain protein
HRE60_RS09675	COG3759	membrane
HRE60_RS09700	COG0305	Participates in initiation and elongation during chromosome replication
HRE60_RS09720	COG2095	MarC family integral membrane protein
HRE60_RS09735	COG0741	lytic transglycosylase activity
HRE60_RS09740	COG1388	LysM domain
HRE60_RS09740	COG3584	3D domain protein
HRE60_RS09745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRE60_RS09760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRE60_RS09770	COG0612	Peptidase, M16
HRE60_RS09775	COG0612	Peptidase, M16
HRE60_RS09800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HRE60_RS09805	COG0488	(ABC) transporter
HRE60_RS09840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE60_RS09845	COG1475	DNA binding
HRE60_RS09885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRE60_RS09890	COG3421	Type III restriction
HRE60_RS09895	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRE60_RS09985	COG0542	response to heat
HRE60_RS10090	COG1401	restriction endodeoxyribonuclease activity
HRE60_RS10165	COG1131	(ABC) transporter
HRE60_RS10270	COG4974	Belongs to the 'phage' integrase family
HRE60_RS10325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE60_RS10355	COG2226	methyltransferase
HRE60_RS10360	COG1396	sequence-specific DNA binding
HRE60_RS10400	COG4974	Belongs to the 'phage' integrase family
HRE60_RS10415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRE60_RS10490	COG2003	Belongs to the UPF0758 family
HRE60_RS10585	COG0629	single-stranded DNA binding
HRE60_RS10695	COG1674	ftsk spoiiie
HRE60_RS10695	COG0697	spore germination
HRE60_RS10725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation