locus-tag	class	description
HSISS4_RS00010	COG0592	DNA-directed DNA polymerase activity
HSISS4_RS00020	COG0012	GTP binding
HSISS4_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HSISS4_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HSISS4_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HSISS4_RS00195	COG0436	Aminotransferase
HSISS4_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HSISS4_RS00220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HSISS4_RS00230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HSISS4_RS00235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HSISS4_RS00255	COG0151	Belongs to the GarS family
HSISS4_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HSISS4_RS00280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HSISS4_RS00295	COG4550	Control of competence regulator ComK, YlbF/YmcA
HSISS4_RS00335	COG0519	Catalyzes the synthesis of GMP from XMP
HSISS4_RS00340	COG1058	Belongs to the CinA family
HSISS4_RS00340	COG1546	Belongs to the CinA family
HSISS4_RS00350	COG1393	Belongs to the ArsC family
HSISS4_RS00435	COG2176	DNA-directed DNA polymerase activity
HSISS4_RS00440	COG2309	aminopeptidase activity
HSISS4_RS00450	COG1846	Transcriptional regulator
HSISS4_RS00465	COG3634	alkyl hydroperoxide reductase activity
HSISS4_RS00470	COG0450	alkyl hydroperoxide reductase
HSISS4_RS00490	COG4463	regulation of RNA biosynthetic process
HSISS4_RS00495	COG0542	response to heat
HSISS4_RS00500	COG1686	Belongs to the peptidase S11 family
HSISS4_RS00505	COG1686	Belongs to the peptidase S11 family
HSISS4_RS00520	COG1045	serine acetyltransferase
HSISS4_RS00530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HSISS4_RS00540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HSISS4_RS00545	COG3688	RNA-binding protein containing a PIN domain
HSISS4_RS00560	COG1476	TRANSCRIPTIONal
HSISS4_RS00565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HSISS4_RS00585	COG3118	belongs to the thioredoxin family
HSISS4_RS00590	COG0492	ferredoxin-NADP+ reductase activity
HSISS4_RS00600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HSISS4_RS00630	COG4509	Sortase family
HSISS4_RS00640	COG3830	Belongs to the UPF0237 family
HSISS4_RS00650	COG0588	phosphoglycerate mutase activity
HSISS4_RS00655	COG1876	peptidase activity
HSISS4_RS00670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HSISS4_RS00690	COG0351	phosphomethylpyrimidine kinase
HSISS4_RS00730	COG0668	transmembrane transport
HSISS4_RS00745	COG0504	CTP synthase activity
HSISS4_RS00755	COG0494	nUDIX hydrolase
HSISS4_RS00765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HSISS4_RS00770	COG0737	Belongs to the 5'-nucleotidase family
HSISS4_RS00795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HSISS4_RS00830	COG1126	abc transporter atp-binding protein
HSISS4_RS00835	COG0765	amino acid transport
HSISS4_RS00855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HSISS4_RS00865	COG0719	Fe-S assembly protein
HSISS4_RS00870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HSISS4_RS00895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HSISS4_RS00905	COG1121	(ABC) transporter
HSISS4_RS00910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HSISS4_RS00920	COG1263	PTS System
HSISS4_RS00920	COG2190	(PTS) system
HSISS4_RS00920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSISS4_RS00935	COG1396	sequence-specific DNA binding
HSISS4_RS00940	COG1132	(ABC) transporter
HSISS4_RS00960	COG4589	Belongs to the CDS family
HSISS4_RS00975	COG4120	Belongs to the binding-protein-dependent transport system permease family
HSISS4_RS00980	COG1116	anion transmembrane transporter activity
HSISS4_RS00980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HSISS4_RS01005	COG0564	pseudouridine synthase activity
HSISS4_RS01010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSISS4_RS01030	COG0561	phosphatase activity
HSISS4_RS01035	COG1349	DNA-binding transcription factor activity
HSISS4_RS01065	COG3279	Response regulator of the LytR AlgR family
HSISS4_RS01075	COG0789	Transcriptional regulator
HSISS4_RS01080	COG1136	(ABC) transporter
HSISS4_RS01080	COG0577	efflux transmembrane transporter activity
HSISS4_RS01085	COG1136	(ABC) transporter
HSISS4_RS01085	COG0577	efflux transmembrane transporter activity
HSISS4_RS01090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HSISS4_RS01105	COG3579	cysteine-type endopeptidase activity
HSISS4_RS01110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSISS4_RS01135	COG0116	Belongs to the methyltransferase superfamily
HSISS4_RS01145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HSISS4_RS01165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HSISS4_RS01180	COG1254	Belongs to the acylphosphatase family
HSISS4_RS01185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HSISS4_RS01210	COG1309	transcriptional regulator
HSISS4_RS01225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HSISS4_RS01245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HSISS4_RS01250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HSISS4_RS01255	COG1187	pseudouridine synthase activity
HSISS4_RS01260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HSISS4_RS01265	COG0569	domain protein
HSISS4_RS01275	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HSISS4_RS01280	COG0671	phosphoesterase, PA-phosphatase related
HSISS4_RS01290	COG2274	protein secretion by the type I secretion system
HSISS4_RS01320	COG0804	urea catabolic process
HSISS4_RS01330	COG0830	nickel cation binding
HSISS4_RS01340	COG0829	nickel cation binding
HSISS4_RS01345	COG0310	cobalt ion transport
HSISS4_RS01355	COG1122	ATPase activity
HSISS4_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS01365	COG1464	Belongs to the NlpA lipoprotein family
HSISS4_RS01375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HSISS4_RS01385	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HSISS4_RS01400	COG1122	ATPase activity
HSISS4_RS01415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HSISS4_RS01430	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS01435	COG5002	protein histidine kinase activity
HSISS4_RS01450	COG1484	DNA-dependent DNA replication
HSISS4_RS01475	COG3716	PTS system mannose fructose sorbose family IID component
HSISS4_RS01480	COG3715	PTS system
HSISS4_RS01495	COG3716	PTS system mannose fructose sorbose family IID component
HSISS4_RS01500	COG3715	PTS system
HSISS4_RS01510	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HSISS4_RS01515	COG0561	phosphatase activity
HSISS4_RS01520	COG2252	PERMEase
HSISS4_RS01525	COG0802	atpase or kinase
HSISS4_RS01530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HSISS4_RS01535	COG1316	TRANSCRIPTIONal
HSISS4_RS01545	COG0195	Participates in both transcription termination and antitermination
HSISS4_RS01550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HSISS4_RS01560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HSISS4_RS01585	COG2244	polysaccharide biosynthetic process
HSISS4_RS01590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HSISS4_RS01595	COG0626	cystathionine gamma-synthase activity
HSISS4_RS01600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HSISS4_RS01625	COG3679	Belongs to the UPF0342 family
HSISS4_RS01630	COG4471	UPF0298 protein
HSISS4_RS01660	COG0517	IMP dehydrogenase activity
HSISS4_RS01670	COG1739	Uncharacterized protein family UPF0029
HSISS4_RS01675	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HSISS4_RS01770	COG0527	aspartate kinase activity
HSISS4_RS01775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HSISS4_RS01780	COG1024	Enoyl-CoA hydratase
HSISS4_RS01785	COG1846	Transcriptional regulator
HSISS4_RS01805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HSISS4_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
HSISS4_RS01815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HSISS4_RS01830	COG0439	Biotin carboxylase
HSISS4_RS01855	COG1349	DNA-binding transcription factor activity
HSISS4_RS01860	COG1105	Belongs to the carbohydrate kinase PfkB family
HSISS4_RS01865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HSISS4_RS01865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HSISS4_RS01865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HSISS4_RS01870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSISS4_RS01875	COG0285	dihydrofolate synthase activity
HSISS4_RS01885	COG1104	cysteine desulfurase activity
HSISS4_RS01890	COG0301	tRNA thio-modification
HSISS4_RS01945	COG0488	(ABC) transporter
HSISS4_RS01965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HSISS4_RS01975	COG0242	peptide deformylase activity
HSISS4_RS02000	COG2357	RelA SpoT domain protein
HSISS4_RS02005	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS02040	COG1702	phosphate starvation-inducible protein PhoH
HSISS4_RS02060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSISS4_RS02060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSISS4_RS02065	COG0656	L-ascorbic acid biosynthetic process
HSISS4_RS02070	COG0583	DNA-binding transcription factor activity
HSISS4_RS02095	COG2223	nitrite transmembrane transporter activity
HSISS4_RS02100	COG4122	O-methyltransferase activity
HSISS4_RS02105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HSISS4_RS02125	COG2801	Transposase and inactivated derivatives
HSISS4_RS02155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HSISS4_RS02160	COG0436	Aminotransferase
HSISS4_RS02175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HSISS4_RS02180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HSISS4_RS02185	COG0726	polysaccharide deacetylase
HSISS4_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HSISS4_RS02245	COG0356	it plays a direct role in the translocation of protons across the membrane
HSISS4_RS02280	COG0772	Belongs to the SEDS family
HSISS4_RS02290	COG0149	triose-phosphate isomerase activity
HSISS4_RS02310	COG0470	DNA polymerase III
HSISS4_RS02315	COG1774	PSP1 C-terminal conserved region
HSISS4_RS02320	COG4467	Involved in initiation control of chromosome replication
HSISS4_RS02330	COG0004	ammonium transporteR
HSISS4_RS02335	COG0347	Belongs to the P(II) protein family
HSISS4_RS02340	COG1705	Flagellar rod assembly protein muramidase FlgJ
HSISS4_RS02340	COG1388	LysM domain
HSISS4_RS02360	COG1283	sodium-dependent phosphate transmembrane transporter activity
HSISS4_RS02390	COG1113	amino acid transport
HSISS4_RS02400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSISS4_RS02400	COG2190	(PTS) system
HSISS4_RS02400	COG1263	PTS System
HSISS4_RS02445	COG0564	pseudouridine synthase activity
HSISS4_RS02465	COG0505	Belongs to the CarA family
HSISS4_RS02485	COG1136	(ABC) transporter
HSISS4_RS02490	COG0577	efflux transmembrane transporter activity
HSISS4_RS02515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSISS4_RS02525	COG1132	(ABC) transporter
HSISS4_RS02555	COG1187	pseudouridine synthase activity
HSISS4_RS02560	COG1473	amidohydrolase
HSISS4_RS02565	COG0686	Belongs to the AlaDH PNT family
HSISS4_RS02575	COG2267	carboxylic ester hydrolase activity
HSISS4_RS02580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSISS4_RS02585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HSISS4_RS02610	COG2801	Transposase and inactivated derivatives
HSISS4_RS02630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HSISS4_RS02665	COG0438	transferase activity, transferring glycosyl groups
HSISS4_RS02680	COG0596	Alpha beta hydrolase
HSISS4_RS02695	COG1272	protein, Hemolysin III
HSISS4_RS02710	COG3425	synthase
HSISS4_RS02720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HSISS4_RS02740	COG2040	homocysteine
HSISS4_RS02760	COG0187	DNA topoisomerase II activity
HSISS4_RS02775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HSISS4_RS02795	COG0539	negative regulation of cytoplasmic translation
HSISS4_RS02835	COG0494	nUDIX hydrolase
HSISS4_RS02840	COG0542	response to heat
HSISS4_RS02845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HSISS4_RS02850	COG4703	Protein of unknown function (DUF1797)
HSISS4_RS02855	COG0765	amino acid transport
HSISS4_RS02860	COG1126	abc transporter atp-binding protein
HSISS4_RS02885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HSISS4_RS02890	COG0768	penicillin binding
HSISS4_RS02895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HSISS4_RS02910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HSISS4_RS02915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HSISS4_RS02920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HSISS4_RS02925	COG0237	dephospho-CoA kinase activity
HSISS4_RS02930	COG2814	Major facilitator Superfamily
HSISS4_RS02940	COG0557	exoribonuclease II activity
HSISS4_RS02955	COG1185	polyribonucleotide nucleotidyltransferase activity
HSISS4_RS02960	COG0006	proline dipeptidase activity
HSISS4_RS02965	COG1609	Transcriptional regulator
HSISS4_RS02995	COG1368	sulfuric ester hydrolase activity
HSISS4_RS03000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HSISS4_RS03025	COG0287	Prephenate dehydrogenase
HSISS4_RS03040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HSISS4_RS03050	COG0077	Prephenate dehydratase
HSISS4_RS03090	COG0488	(ABC) transporter
HSISS4_RS03125	COG0640	Transcriptional regulator
HSISS4_RS03130	COG2217	Heavy metal translocating P-type atpase
HSISS4_RS03145	COG2807	transmembrane transport
HSISS4_RS03150	COG1307	EDD domain protein, DegV family
HSISS4_RS03160	COG3142	Participates in the control of copper homeostasis
HSISS4_RS03190	COG1120	ATPase activity
HSISS4_RS03200	COG2819	hydrolase of the alpha beta superfamily
HSISS4_RS03205	COG1597	lipid kinase activity
HSISS4_RS03215	COG2261	transglycosylase associated protein
HSISS4_RS03220	COG3237	CsbD-like
HSISS4_RS03225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSISS4_RS03230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HSISS4_RS03235	COG0022	dehydrogenase e1 component
HSISS4_RS03240	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSISS4_RS03300	COG0659	secondary active sulfate transmembrane transporter activity
HSISS4_RS03305	COG3689	TIGRFAM TIGR03943 family protein
HSISS4_RS03310	COG0701	Predicted permease
HSISS4_RS03315	COG2183	response to ionizing radiation
HSISS4_RS03335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HSISS4_RS03360	COG0826	peptidase U32
HSISS4_RS03370	COG1268	BioY protein
HSISS4_RS03380	COG4443	Transcriptional Coactivator p15 (PC4)
HSISS4_RS03385	COG1914	H( )-stimulated, divalent metal cation uptake system
HSISS4_RS03395	COG0494	nUDIX hydrolase
HSISS4_RS03415	COG1388	LysM domain
HSISS4_RS03415	COG1705	Flagellar rod assembly protein muramidase FlgJ
HSISS4_RS03435	COG0588	phosphoglycerate mutase activity
HSISS4_RS03440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HSISS4_RS03455	COG0561	phosphatase activity
HSISS4_RS03470	COG4221	oxidoreductase activity
HSISS4_RS03475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HSISS4_RS03500	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HSISS4_RS03505	COG3620	sequence-specific DNA binding
HSISS4_RS03530	COG1704	LemA family
HSISS4_RS03535	COG0501	Belongs to the peptidase M48B family
HSISS4_RS03570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HSISS4_RS03580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HSISS4_RS03590	COG0783	Belongs to the Dps family
HSISS4_RS03595	COG0735	belongs to the Fur family
HSISS4_RS03600	COG4483	Protein conserved in bacteria
HSISS4_RS03605	COG1940	carbohydrate kinase activity
HSISS4_RS03610	COG1217	gtp-binding protein TYPA
HSISS4_RS03635	COG0849	cell division
HSISS4_RS03645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HSISS4_RS03655	COG0762	integral membrane protein
HSISS4_RS03665	COG3599	regulation of cell shape
HSISS4_RS03675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HSISS4_RS03680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HSISS4_RS03685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HSISS4_RS03690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HSISS4_RS03695	COG0372	Belongs to the citrate synthase family
HSISS4_RS03735	COG0513	Belongs to the DEAD box helicase family
HSISS4_RS03745	COG0488	(ABC) transporter
HSISS4_RS03760	COG0392	lysyltransferase activity
HSISS4_RS03760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HSISS4_RS03765	COG3442	glutamine amidotransferase
HSISS4_RS03770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HSISS4_RS03795	COG2384	SAM-dependent methyltransferase
HSISS4_RS03810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HSISS4_RS03820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HSISS4_RS03830	COG1088	dTDP-glucose 4,6-dehydratase activity
HSISS4_RS03845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HSISS4_RS03855	COG0647	UMP catabolic process
HSISS4_RS03895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HSISS4_RS03905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HSISS4_RS03915	COG0107	imidazoleglycerol-phosphate synthase activity
HSISS4_RS03955	COG5263	repeat protein
HSISS4_RS03955	COG0366	Alpha amylase catalytic
HSISS4_RS03960	COG0366	Alpha amylase catalytic
HSISS4_RS03960	COG5263	repeat protein
HSISS4_RS03980	COG0519	Catalyzes the synthesis of GMP from XMP
HSISS4_RS03990	COG5263	repeat protein
HSISS4_RS03990	COG0366	Alpha amylase catalytic
HSISS4_RS03995	COG0772	Belongs to the SEDS family
HSISS4_RS04000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HSISS4_RS04015	COG0300	oxidoreductase activity
HSISS4_RS04025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HSISS4_RS04025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HSISS4_RS04045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HSISS4_RS04070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HSISS4_RS04075	COG1438	arginine binding
HSISS4_RS04080	COG0497	DNA recombination
HSISS4_RS04090	COG2755	lipolytic protein G-D-S-L family
HSISS4_RS04100	COG0776	regulation of translation
HSISS4_RS04110	COG0167	dihydroorotate dehydrogenase activity
HSISS4_RS04115	COG0588	phosphoglycerate mutase activity
HSISS4_RS04135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HSISS4_RS04140	COG0066	3-isopropylmalate dehydratase activity
HSISS4_RS04155	COG0469	pyruvate kinase activity
HSISS4_RS04180	COG3842	ATPase activity
HSISS4_RS04205	COG0716	FMN binding
HSISS4_RS04220	COG0038	chloride channel
HSISS4_RS04225	COG0335	large ribosomal subunit rRNA binding
HSISS4_RS04240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HSISS4_RS04245	COG1956	GAF domain-containing protein
HSISS4_RS04250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HSISS4_RS04255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HSISS4_RS04255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HSISS4_RS04260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HSISS4_RS04310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HSISS4_RS04335	COG0765	amino acid transport
HSISS4_RS04340	COG0765	amino acid transport
HSISS4_RS04345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS04350	COG1126	abc transporter atp-binding protein
HSISS4_RS04360	COG0765	amino acid transport
HSISS4_RS04365	COG0765	amino acid transport
HSISS4_RS04370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS04375	COG1126	abc transporter atp-binding protein
HSISS4_RS04380	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS04385	COG5002	protein histidine kinase activity
HSISS4_RS04390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HSISS4_RS04395	COG2832	Protein of unknown function (DUF454)
HSISS4_RS04400	COG2348	transferase activity, transferring amino-acyl groups
HSISS4_RS04425	COG0778	Nitroreductase
HSISS4_RS04435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HSISS4_RS04440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HSISS4_RS04445	COG2884	Cell division ATP-binding protein ftsE
HSISS4_RS04450	COG2177	Part of the ABC transporter FtsEX involved in
HSISS4_RS04455	COG1051	belongs to the nudix hydrolase family
HSISS4_RS04460	COG0628	permease
HSISS4_RS04475	COG1705	Flagellar rod assembly protein muramidase FlgJ
HSISS4_RS04500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HSISS4_RS04505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HSISS4_RS04535	COG1573	uracil-dna glycosylase
HSISS4_RS04555	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HSISS4_RS04565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HSISS4_RS04580	COG0813	purine-nucleoside phosphorylase activity
HSISS4_RS04585	COG1316	TRANSCRIPTIONal
HSISS4_RS04615	COG0297	glycogen (starch) synthase activity
HSISS4_RS04630	COG1216	Glycosyl transferase, family 2
HSISS4_RS04630	COG1442	glycosyl transferase family 8
HSISS4_RS04645	COG0562	UDP-galactopyranose mutase
HSISS4_RS04655	COG0438	transferase activity, transferring glycosyl groups
HSISS4_RS04665	COG0561	phosphatase activity
HSISS4_RS04680	COG0588	phosphoglycerate mutase activity
HSISS4_RS04685	COG0628	permease
HSISS4_RS04710	COG4667	esterase of the alpha-beta hydrolase superfamily
HSISS4_RS04720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HSISS4_RS04750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HSISS4_RS04755	COG0022	dehydrogenase e1 component
HSISS4_RS04755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSISS4_RS04760	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSISS4_RS04765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSISS4_RS04775	COG0860	N-Acetylmuramoyl-L-alanine amidase
HSISS4_RS04780	COG1523	belongs to the glycosyl hydrolase 13 family
HSISS4_RS04785	COG2822	iron ion transport
HSISS4_RS04790	COG2837	iron assimilation
HSISS4_RS04795	COG0672	)-iron permease
HSISS4_RS04800	COG0805	protein transport
HSISS4_RS04805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HSISS4_RS04810	COG3842	ATPase activity
HSISS4_RS04815	COG3833	ABC-type maltose transport systems, permease component
HSISS4_RS04820	COG1175	transmembrane transport
HSISS4_RS04830	COG1609	Transcriptional regulator
HSISS4_RS04835	COG1640	4-alpha-glucanotransferase
HSISS4_RS04840	COG0058	SHG alpha-glucan phosphorylase activity
HSISS4_RS04855	COG0095	Lipoate-protein ligase
HSISS4_RS04870	COG0704	Plays a role in the regulation of phosphate uptake
HSISS4_RS04885	COG0581	inorganic phosphate transmembrane transporter activity
HSISS4_RS04890	COG0573	inorganic phosphate transmembrane transporter activity
HSISS4_RS04900	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HSISS4_RS04900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HSISS4_RS04905	COG0483	inositol monophosphate 1-phosphatase activity
HSISS4_RS04915	COG1393	Belongs to the ArsC family
HSISS4_RS04920	COG0196	riboflavin kinase activity
HSISS4_RS04925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HSISS4_RS04955	COG2873	o-acetylhomoserine
HSISS4_RS04960	COG0210	DNA helicase
HSISS4_RS04965	COG1115	amino acid carrier protein
HSISS4_RS04975	COG2207	Transcriptional regulator
HSISS4_RS04975	COG1917	Cupin 2, conserved barrel domain protein
HSISS4_RS04980	COG0737	Belongs to the 5'-nucleotidase family
HSISS4_RS04985	COG0765	amino acid transport
HSISS4_RS04990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS05005	COG0284	orotidine-5'-phosphate decarboxylase activity
HSISS4_RS05025	COG1567	CRISPR-associated RAMP protein, Csm4 family
HSISS4_RS05030	COG1337	RAMP superfamily
HSISS4_RS05055	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HSISS4_RS05065	COG0167	dihydroorotate dehydrogenase activity
HSISS4_RS05085	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HSISS4_RS05105	COG0534	Mate efflux family protein
HSISS4_RS05110	COG4607	ABC-type enterochelin transport system periplasmic component
HSISS4_RS05130	COG0028	Belongs to the TPP enzyme family
HSISS4_RS05150	COG1063	alcohol dehydrogenase
HSISS4_RS05160	COG1230	cation diffusion facilitator family transporter
HSISS4_RS05175	COG1309	transcriptional regulator
HSISS4_RS05195	COG0596	Alpha beta hydrolase
HSISS4_RS05200	COG3321	synthase
HSISS4_RS05200	COG0604	alcohol dehydrogenase
HSISS4_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
HSISS4_RS05215	COG1122	ATPase activity
HSISS4_RS05225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HSISS4_RS05245	COG1136	(ABC) transporter
HSISS4_RS05245	COG4591	ABC-type transport system involved in lipoprotein release permease component
HSISS4_RS05270	COG1174	glycine betaine transport
HSISS4_RS05285	COG1846	Transcriptional regulator
HSISS4_RS05305	COG3527	Alpha-acetolactate decarboxylase
HSISS4_RS05310	COG0028	Belongs to the TPP enzyme family
HSISS4_RS05375	COG1131	(ABC) transporter
HSISS4_RS05380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HSISS4_RS05385	COG0758	DNA mediated transformation
HSISS4_RS05390	COG1940	carbohydrate kinase activity
HSISS4_RS05400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HSISS4_RS05410	COG1827	regulation of RNA biosynthetic process
HSISS4_RS05420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HSISS4_RS05430	COG2188	Transcriptional regulator
HSISS4_RS05435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HSISS4_RS05435	COG0519	Catalyzes the synthesis of GMP from XMP
HSISS4_RS05445	COG1064	alcohol dehydrogenase
HSISS4_RS05460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HSISS4_RS05465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS05470	COG1126	abc transporter atp-binding protein
HSISS4_RS05475	COG0765	amino acid transport
HSISS4_RS05480	COG2824	Alkylphosphonate utilization operon protein PhnA
HSISS4_RS05485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HSISS4_RS05495	COG1705	Flagellar rod assembly protein muramidase FlgJ
HSISS4_RS05495	COG1388	LysM domain
HSISS4_RS05515	COG3443	Belongs to the bacterial solute-binding protein 9 family
HSISS4_RS05515	COG0803	Belongs to the bacterial solute-binding protein 9 family
HSISS4_RS05565	COG0720	synthase
HSISS4_RS05575	COG0251	oxidation-reduction process
HSISS4_RS05590	COG0017	Asparaginyl-tRNA synthetase
HSISS4_RS05595	COG0436	Aminotransferase
HSISS4_RS05605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HSISS4_RS05605	COG1199	ATP-dependent helicase activity
HSISS4_RS05615	COG1079	Belongs to the binding-protein-dependent transport system permease family
HSISS4_RS05620	COG4603	Belongs to the binding-protein-dependent transport system permease family
HSISS4_RS05625	COG3845	ABC transporter
HSISS4_RS05630	COG1744	ABC transporter substrate-binding protein PnrA-like
HSISS4_RS05635	COG0295	cytidine deaminase activity
HSISS4_RS05640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HSISS4_RS05645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HSISS4_RS05650	COG2813	Specifically methylates the guanine in position
HSISS4_RS05665	COG5002	protein histidine kinase activity
HSISS4_RS05670	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS05685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HSISS4_RS05690	COG4684	Psort location CytoplasmicMembrane, score
HSISS4_RS05695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HSISS4_RS05715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HSISS4_RS05720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HSISS4_RS05725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HSISS4_RS05735	COG1696	Membrane protein involved in D-alanine export
HSISS4_RS05750	COG2801	Transposase and inactivated derivatives
HSISS4_RS05765	COG1132	(ABC) transporter
HSISS4_RS05790	COG0009	L-threonylcarbamoyladenylate synthase
HSISS4_RS05795	COG2890	protein-(glutamine-N5) methyltransferase activity
HSISS4_RS05805	COG1435	thymidine kinase activity
HSISS4_RS05810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HSISS4_RS05815	COG0625	glutathione transferase activity
HSISS4_RS05820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HSISS4_RS05845	COG0346	lactoylglutathione lyase activity
HSISS4_RS05850	COG3764	Sortase (surface protein transpeptidase)
HSISS4_RS05870	COG0488	(ABC) transporter
HSISS4_RS05895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSISS4_RS05900	COG1328	CTP reductase activity
HSISS4_RS05900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HSISS4_RS05935	COG1196	nuclear chromosome segregation
HSISS4_RS05950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HSISS4_RS05960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HSISS4_RS05970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HSISS4_RS05975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HSISS4_RS05990	COG1011	Hydrolase
HSISS4_RS05995	COG1760	l-serine dehydratase
HSISS4_RS06000	COG1760	l-serine dehydratase
HSISS4_RS06005	COG5492	domain, Protein
HSISS4_RS06005	COG3583	domain protein
HSISS4_RS06005	COG1621	beta-fructofuranosidase activity
HSISS4_RS06010	COG0697	spore germination
HSISS4_RS06040	COG2249	NAD(P)H dehydrogenase (quinone) activity
HSISS4_RS06045	COG1404	Belongs to the peptidase S8 family
HSISS4_RS06065	COG4555	ABC transporter
HSISS4_RS06070	COG2197	response regulator
HSISS4_RS06075	COG4585	Histidine kinase
HSISS4_RS06085	COG1131	(ABC) transporter
HSISS4_RS06100	COG0385	Bile acid
HSISS4_RS06110	COG0842	Transport permease protein
HSISS4_RS06115	COG1131	(ABC) transporter
HSISS4_RS06135	COG0577	efflux transmembrane transporter activity
HSISS4_RS06140	COG1136	(ABC) transporter
HSISS4_RS06150	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS06160	COG2233	PERMEase
HSISS4_RS06165	COG2801	Transposase and inactivated derivatives
HSISS4_RS06180	COG0534	Mate efflux family protein
HSISS4_RS06195	COG1114	Component of the transport system for branched-chain amino acids
HSISS4_RS06200	COG1482	cell wall glycoprotein biosynthetic process
HSISS4_RS06210	COG2323	membrane
HSISS4_RS06215	COG3237	CsbD-like
HSISS4_RS06230	COG0531	amino acid
HSISS4_RS06240	COG0386	Belongs to the glutathione peroxidase family
HSISS4_RS06265	COG4989	oxidoreductase activity
HSISS4_RS06275	COG1476	TRANSCRIPTIONal
HSISS4_RS06290	COG2514	catechol 2,3-dioxygenase activity
HSISS4_RS06295	COG1959	2 iron, 2 sulfur cluster binding
HSISS4_RS06305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HSISS4_RS06310	COG1131	(ABC) transporter
HSISS4_RS06325	COG2205	protein histidine kinase activity
HSISS4_RS06330	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS06335	COG0778	Nitroreductase
HSISS4_RS06350	COG0656	L-ascorbic acid biosynthetic process
HSISS4_RS06360	COG3250	beta-galactosidase activity
HSISS4_RS06365	COG2211	Major facilitator Superfamily
HSISS4_RS06365	COG2190	(PTS) system
HSISS4_RS06370	COG2017	converts alpha-aldose to the beta-anomer
HSISS4_RS06375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HSISS4_RS06390	COG1609	Transcriptional regulator
HSISS4_RS06395	COG0366	Alpha amylase catalytic
HSISS4_RS06405	COG2801	Transposase and inactivated derivatives
HSISS4_RS06410	COG5002	protein histidine kinase activity
HSISS4_RS06415	COG0745	RESPONSE REGULATOR receiver
HSISS4_RS06420	COG0577	efflux transmembrane transporter activity
HSISS4_RS06425	COG1136	(ABC) transporter
HSISS4_RS06455	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HSISS4_RS06460	COG1461	Dihydroxyacetone kinase
HSISS4_RS06465	COG2376	Dihydroxyacetone kinase
HSISS4_RS06490	COG0640	Transcriptional regulator
HSISS4_RS06505	COG5263	repeat protein
HSISS4_RS06505	COG0366	Alpha amylase catalytic
HSISS4_RS06515	COG5263	repeat protein
HSISS4_RS06515	COG0366	Alpha amylase catalytic
HSISS4_RS06520	COG0366	Alpha amylase catalytic
HSISS4_RS06520	COG5263	repeat protein
HSISS4_RS06525	COG2801	Transposase and inactivated derivatives
HSISS4_RS06555	COG5263	repeat protein
HSISS4_RS06555	COG0366	Alpha amylase catalytic
HSISS4_RS06560	COG0366	Alpha amylase catalytic
HSISS4_RS06560	COG5263	repeat protein
HSISS4_RS06560	COG0366	Alpha amylase catalytic
HSISS4_RS06560	COG5263	repeat protein
HSISS4_RS06615	COG0392	lysyltransferase activity
HSISS4_RS06615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HSISS4_RS06620	COG0679	Auxin Efflux Carrier
HSISS4_RS06625	COG0281	malic enzyme
HSISS4_RS06635	COG0583	DNA-binding transcription factor activity
HSISS4_RS06640	COG2801	Transposase and inactivated derivatives
HSISS4_RS06660	COG0477	Major facilitator Superfamily
HSISS4_RS06670	COG0110	maltose O-acetyltransferase activity
HSISS4_RS06675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HSISS4_RS06685	COG5263	repeat protein
HSISS4_RS06685	COG0366	Alpha amylase catalytic
HSISS4_RS06730	COG0438	transferase activity, transferring glycosyl groups
HSISS4_RS06740	COG0653	protein targeting
HSISS4_RS06765	COG1216	Glycosyl transferase, family 2
HSISS4_RS06765	COG1442	glycosyl transferase family 8
HSISS4_RS06770	COG0419	ATPase involved in DNA repair
HSISS4_RS06775	COG0420	3'-5' exonuclease activity
HSISS4_RS06785	COG3064	Membrane
HSISS4_RS06800	COG0488	(ABC) transporter
HSISS4_RS06805	COG1132	(ABC) transporter
HSISS4_RS06810	COG1132	(ABC) transporter
HSISS4_RS06835	COG0058	SHG alpha-glucan phosphorylase activity
HSISS4_RS06840	COG0297	glycogen (starch) synthase activity
HSISS4_RS06845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HSISS4_RS06850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HSISS4_RS06855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HSISS4_RS06860	COG1523	belongs to the glycosyl hydrolase 13 family
HSISS4_RS06895	COG2197	response regulator
HSISS4_RS06900	COG4585	Histidine kinase
HSISS4_RS06910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HSISS4_RS06915	COG2815	serine threonine protein kinase
HSISS4_RS06915	COG0515	serine threonine protein kinase
HSISS4_RS06925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HSISS4_RS06925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HSISS4_RS06935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HSISS4_RS06950	COG0552	protein localization to endoplasmic reticulum
HSISS4_RS06955	COG0561	phosphatase activity
HSISS4_RS06960	COG0561	phosphatase activity
HSISS4_RS06965	COG1725	Transcriptional regulator
HSISS4_RS06970	COG1131	(ABC) transporter
HSISS4_RS06980	COG4608	Belongs to the ABC transporter superfamily
HSISS4_RS06985	COG0444	Belongs to the ABC transporter superfamily
HSISS4_RS06990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HSISS4_RS06995	COG0601	transmembrane transport
HSISS4_RS07000	COG4166	transmembrane transport
HSISS4_RS07005	COG4166	transmembrane transport
HSISS4_RS07010	COG0280	phosphate acetyltransferase
HSISS4_RS07015	COG0564	pseudouridine synthase activity
HSISS4_RS07025	COG2357	RelA SpoT domain protein
HSISS4_RS07040	COG1104	cysteine desulfurase activity
HSISS4_RS07055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HSISS4_RS07085	COG1215	transferase activity, transferring glycosyl groups
HSISS4_RS07100	COG1442	glycosyl transferase family 8
HSISS4_RS07100	COG1216	Glycosyl transferase, family 2
HSISS4_RS07120	COG1091	dTDP-4-dehydrorhamnose reductase activity
HSISS4_RS07130	COG0463	Glycosyl transferase, family 2
HSISS4_RS07135	COG2151	metal-sulfur cluster biosynthetic enzyme
HSISS4_RS07140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HSISS4_RS07145	COG0358	DNA primase activity
HSISS4_RS07150	COG1970	mechanosensitive ion channel activity
HSISS4_RS07155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HSISS4_RS07160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS07165	COG0436	Aminotransferase
HSISS4_RS07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS07180	COG1051	belongs to the nudix hydrolase family
HSISS4_RS07205	COG0765	amino acid transport
HSISS4_RS07225	COG1187	pseudouridine synthase activity
HSISS4_RS07260	COG0560	Phosphoserine phosphatase
HSISS4_RS07270	COG0187	DNA topoisomerase II activity
HSISS4_RS07280	COG1346	cytolysis
HSISS4_RS07285	COG1380	Effector of murein hydrolase LrgA
HSISS4_RS07295	COG1393	Belongs to the ArsC family
HSISS4_RS07300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HSISS4_RS07305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HSISS4_RS07320	COG1940	carbohydrate kinase activity
HSISS4_RS07325	COG0346	lactoylglutathione lyase activity
HSISS4_RS07340	COG1177	transmembrane transport
HSISS4_RS07345	COG1176	ABC-type spermidine putrescine transport system, permease component I
HSISS4_RS07385	COG0531	amino acid
HSISS4_RS07390	COG0285	dihydrofolate synthase activity
HSISS4_RS07425	COG3615	Tellurite resistance protein tehB
HSISS4_RS07425	COG0500	methyltransferase
HSISS4_RS07445	COG0708	Exodeoxyribonuclease III
HSISS4_RS07470	COG1597	lipid kinase activity
HSISS4_RS07480	COG4708	membrane
HSISS4_RS07490	COG0024	Methionine aminopeptidase
HSISS4_RS07495	COG4109	DRTGG domain
HSISS4_RS07500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HSISS4_RS07505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HSISS4_RS07510	COG0658	competence protein
HSISS4_RS07510	COG2333	competence protein COMEC
HSISS4_RS07515	COG1555	photosystem II stabilization
HSISS4_RS07515	COG1596	polysaccharide export
HSISS4_RS07520	COG0204	Acyl-transferase
HSISS4_RS07525	COG0726	polysaccharide deacetylase
HSISS4_RS07530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HSISS4_RS07540	COG0513	Belongs to the DEAD box helicase family
HSISS4_RS07560	COG1396	sequence-specific DNA binding
HSISS4_RS07565	COG2211	Major facilitator Superfamily
HSISS4_RS07580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HSISS4_RS07600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS07605	COG1126	abc transporter atp-binding protein
HSISS4_RS07610	COG0765	amino acid transport
HSISS4_RS07615	COG0765	amino acid transport
HSISS4_RS07620	COG1181	Belongs to the D-alanine--D-alanine ligase family
HSISS4_RS07630	COG2217	Heavy metal translocating P-type atpase
HSISS4_RS07645	COG0159	tryptophan synthase activity
HSISS4_RS07650	COG0133	tryptophan synthase activity
HSISS4_RS07655	COG0135	phosphoribosylanthranilate isomerase activity
HSISS4_RS07670	COG0512	Glutamine amidotransferase of anthranilate synthase
HSISS4_RS07675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HSISS4_RS07685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HSISS4_RS07710	COG1136	(ABC) transporter
HSISS4_RS07710	COG4591	ABC-type transport system involved in lipoprotein release permease component
HSISS4_RS07720	COG0789	Transcriptional regulator
HSISS4_RS07725	COG2176	DNA-directed DNA polymerase activity
HSISS4_RS07735	COG2151	metal-sulfur cluster biosynthetic enzyme
HSISS4_RS07745	COG2081	HI0933 family
HSISS4_RS07770	COG1131	(ABC) transporter
HSISS4_RS07775	COG0537	adenosine 5'-monophosphoramidase activity
HSISS4_RS07810	COG2226	methyltransferase
HSISS4_RS07815	COG0799	negative regulation of ribosome biogenesis
HSISS4_RS07820	COG1713	HD superfamily hydrolase involved in NAD metabolism
HSISS4_RS07825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HSISS4_RS07830	COG1534	Rna-binding protein
HSISS4_RS07835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HSISS4_RS07840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HSISS4_RS07850	COG1063	alcohol dehydrogenase
HSISS4_RS07890	COG1216	Glycosyl transferase, family 2
HSISS4_RS07890	COG1442	glycosyl transferase family 8
HSISS4_RS07895	COG1442	glycosyl transferase family 8
HSISS4_RS07900	COG2723	6-phospho-beta-galactosidase activity
HSISS4_RS07905	COG1335	isochorismatase
HSISS4_RS07915	COG0436	Aminotransferase
HSISS4_RS07920	COG0589	response to stress
HSISS4_RS07930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HSISS4_RS07940	COG1253	flavin adenine dinucleotide binding
HSISS4_RS07945	COG1119	ATPase activity
HSISS4_RS07955	COG0025	NhaP-type Na H and K H
HSISS4_RS07965	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HSISS4_RS07970	COG1242	4 iron, 4 sulfur cluster binding
HSISS4_RS07975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HSISS4_RS07980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HSISS4_RS07985	COG0742	ribosomal rna small subunit methyltransferase
HSISS4_RS07990	COG0492	ferredoxin-NADP+ reductase activity
HSISS4_RS08000	COG1126	abc transporter atp-binding protein
HSISS4_RS08010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSISS4_RS08025	COG1882	Formate acetyltransferase
HSISS4_RS08050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HSISS4_RS08070	COG2936	dipeptidyl-peptidase activity
HSISS4_RS08090	COG1132	(ABC) transporter
HSISS4_RS08095	COG1132	(ABC) transporter
HSISS4_RS08115	COG4470	Protein conserved in bacteria
HSISS4_RS08120	COG0737	Belongs to the 5'-nucleotidase family
HSISS4_RS08135	COG0513	Belongs to the DEAD box helicase family
HSISS4_RS08145	COG0768	penicillin binding
HSISS4_RS08185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HSISS4_RS08190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HSISS4_RS08200	COG4152	abc transporter atp-binding protein
HSISS4_RS08205	COG1811	Na channel or pump
HSISS4_RS08245	COG1116	anion transmembrane transporter activity
HSISS4_RS08255	COG0443	Heat shock 70 kDa protein
HSISS4_RS08280	COG0561	phosphatase activity
HSISS4_RS08285	COG0252	asparaginase activity
HSISS4_RS08290	COG3655	Transcriptional regulator
HSISS4_RS08310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HSISS4_RS08325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HSISS4_RS08330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HSISS4_RS08335	COG0653	protein targeting
HSISS4_RS08345	COG1482	cell wall glycoprotein biosynthetic process
HSISS4_RS08350	COG1940	carbohydrate kinase activity
HSISS4_RS08355	COG2190	(PTS) system
HSISS4_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSISS4_RS08355	COG1263	PTS System
HSISS4_RS08360	COG1621	beta-fructofuranosidase activity
HSISS4_RS08365	COG1609	Transcriptional regulator
HSISS4_RS08380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HSISS4_RS08385	COG2131	deaminase
HSISS4_RS08390	COG0006	proline dipeptidase activity
HSISS4_RS08400	COG1131	(ABC) transporter
HSISS4_RS08465	COG1194	a g-specific adenine glycosylase
HSISS4_RS08480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSISS4_RS08480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSISS4_RS08505	COG0681	Belongs to the peptidase S26 family
HSISS4_RS08510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HSISS4_RS08520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HSISS4_RS08530	COG0456	acetyltransferase
HSISS4_RS08535	COG1214	PFAM Peptidase M22, glycoprotease
HSISS4_RS08550	COG3942	CHAP domain
HSISS4_RS08555	COG0174	glutamine synthetase
HSISS4_RS08560	COG0789	Transcriptional regulator
HSISS4_RS08570	COG0126	phosphoglycerate kinase activity
HSISS4_RS08600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSISS4_RS08645	COG0084	hydrolase, TatD family'
HSISS4_RS08650	COG1832	CoA-binding protein
HSISS4_RS08655	COG3118	belongs to the thioredoxin family
HSISS4_RS08775	COG2249	NAD(P)H dehydrogenase (quinone) activity
HSISS4_RS08790	COG0706	membrane insertase activity
HSISS4_RS08840	COG4166	transmembrane transport
HSISS4_RS08880	COG0756	dUTP diphosphatase activity
HSISS4_RS08890	COG0431	NADPH-dependent FMN reductase
HSISS4_RS08890	COG1053	succinate dehydrogenase
HSISS4_RS08890	COG3976	FMN-binding domain protein
HSISS4_RS08910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HSISS4_RS08915	COG0457	Tetratricopeptide repeat
HSISS4_RS08915	COG0705	Rhomboid family
HSISS4_RS08920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HSISS4_RS08935	COG0647	UMP catabolic process
HSISS4_RS08940	COG2226	methyltransferase
HSISS4_RS08975	COG0425	Belongs to the sulfur carrier protein TusA family
HSISS4_RS08980	COG2391	methyltransferase activity
HSISS4_RS08985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSISS4_RS08995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSISS4_RS09005	COG1363	Peptidase, m42
HSISS4_RS09010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HSISS4_RS09015	COG1266	CAAX protease self-immunity
HSISS4_RS09070	COG1459	type II secretion system
HSISS4_RS09075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HSISS4_RS09110	COG0440	acetolactate synthase activity
HSISS4_RS09115	COG0028	Belongs to the TPP enzyme family
HSISS4_RS09120	COG0129	dihydroxy-acid dehydratase activity
HSISS4_RS09125	COG1461	Dihydroxyacetone kinase
HSISS4_RS09135	COG0534	Mate efflux family protein
HSISS4_RS09155	COG1454	alcohol dehydrogenase
HSISS4_RS09155	COG1012	belongs to the aldehyde dehydrogenase family
HSISS4_RS09160	COG3590	peptidase
HSISS4_RS09165	COG0366	Alpha amylase catalytic
HSISS4_RS09170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSISS4_RS09170	COG1263	PTS System
HSISS4_RS09175	COG2188	Transcriptional regulator
HSISS4_RS09180	COG4475	Protein of unknown function (DUF436)
HSISS4_RS09200	COG3328	transposase activity
HSISS4_RS09245	COG0563	adenylate kinase activity
HSISS4_RS09250	COG0201	protein transport
HSISS4_RS09285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HSISS4_RS09355	COG0051	transcription antitermination factor activity, RNA binding
HSISS4_RS09375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSISS4_RS09400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HSISS4_RS09405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HSISS4_RS09430	COG1328	CTP reductase activity
HSISS4_RS09440	COG0602	queuosine metabolic process
HSISS4_RS09450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSISS4_RS09475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HSISS4_RS09485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSISS4_RS09510	COG1105	Belongs to the carbohydrate kinase PfkB family
HSISS4_RS09515	COG3300	MHYT domain
HSISS4_RS09515	COG5001	Diguanylate cyclase
HSISS4_RS09550	COG0494	nUDIX hydrolase
HSISS4_RS09555	COG1695	Transcriptional regulator
HSISS4_RS09570	COG1511	domain protein
HSISS4_RS09570	COG1511	domain protein
HSISS4_RS09580	COG3759	membrane
HSISS4_RS09600	COG0305	Participates in initiation and elongation during chromosome replication
HSISS4_RS09620	COG2095	MarC family integral membrane protein
HSISS4_RS09635	COG0741	lytic transglycosylase activity
HSISS4_RS09640	COG1388	LysM domain
HSISS4_RS09640	COG3584	3D domain protein
HSISS4_RS09645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HSISS4_RS09660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HSISS4_RS09670	COG0612	Peptidase, M16
HSISS4_RS09675	COG0612	Peptidase, M16
HSISS4_RS09705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSISS4_RS09710	COG0488	(ABC) transporter
HSISS4_RS09745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HSISS4_RS09750	COG1475	DNA binding