locus-tag class description FOC72_RS00035 ENOG4105DIB Oligopeptide-binding protein FOC72_RS00045 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC72_RS00055 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FOC72_RS00090 ENOG4108JJB ABC transporter FOC72_RS00100 ENOG4107BMA Transglycosylase associated protein FOC72_RS00120 ENOG41061M1 UPF0337 protein FOC72_RS00130 ENOG4107UWA esterase FOC72_RS00135 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOC72_RS00145 ENOG4105CDH Citrulline--aspartate ligase FOC72_RS00150 ENOG4105CH7 arginosuccinase FOC72_RS00155 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FOC72_RS00180 ENOG41084B3 50S ribosomal protein l34 FOC72_RS00195 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC72_RS00205 ENOG4105VMP Transcriptional regulator FOC72_RS00215 ENOG4105F8V Hydrolase, tatD family FOC72_RS00235 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOC72_RS00255 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC72_RS00260 ENOG4105DJV ribulose-phosphate 3-epimerase FOC72_RS00265 ENOG4105FJ0 thiamine FOC72_RS00275 ENOG4105EQI Metal Dependent Phosphohydrolase FOC72_RS00280 ENOG4105DFT pur operon repressor FOC72_RS00290 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOC72_RS00295 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOC72_RS00300 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOC72_RS00305 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC72_RS00310 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC72_RS00340 ENOG4105DRP amino acid AbC transporter FOC72_RS00350 ENOG4105CDA abc transporter atp-binding protein FOC72_RS00375 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC72_RS00385 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC72_RS00390 ENOG4105KNE Phosphatidate cytidylyltransferase FOC72_RS00395 ENOG4105DZP Membrane-associated zinc metalloprotease FOC72_RS00400 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOC72_RS00405 ENOG4105KWG Pfam:DUF1696 FOC72_RS00415 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC72_RS00420 ENOG4106F1P AAA ATPase, central domain protein FOC72_RS00455 ENOG4105C88 aminopeptidase FOC72_RS00465 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC72_RS00480 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOC72_RS00485 ENOG4105E5G Alpha beta hydrolase fold FOC72_RS00500 ENOG4105K63 Thioredoxin FOC72_RS00505 ENOG4105DPN Oligoendopeptidase f FOC72_RS00520 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC72_RS00525 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOC72_RS00530 ENOG4105D7W serine acetyltransferase FOC72_RS00550 ENOG4105C8N cysteinyl-tRNA synthetase FOC72_RS00555 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FOC72_RS00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC72_RS00580 ENOG4105M0M Tetracycline resistance protein FOC72_RS00585 ENOG4105EPR degv family FOC72_RS00590 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOC72_RS00595 ENOG4108UJD 30S ribosomal protein S9 FOC72_RS00615 ENOG4106ZEE Diacylglycerol kinase FOC72_RS00660 ENOG4107PBV potassium channel FOC72_RS00670 ENOG4105CK2 sodium dicarboxylate symporter FOC72_RS00680 ENOG4105D7K pfkb domain protein FOC72_RS00685 ENOG4108Z5V transcriptional regulator, merr family FOC72_RS00690 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOC72_RS00700 ENOG4105VUC UPF0237 protein FOC72_RS00705 ENOG4105CAG UPF0210 protein FOC72_RS00720 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC72_RS00725 ENOG4108UZE carboxy-peptidase FOC72_RS00750 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOC72_RS00755 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC72_RS00765 ENOG4105CFG Acts as a chaperone (By similarity) FOC72_RS00775 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC72_RS00780 ENOG4105EEN pathogenesis FOC72_RS00785 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC72_RS00795 ENOG4105PUK Membrane FOC72_RS00800 ENOG4108UIC UPF0340 protein FOC72_RS00805 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC72_RS00815 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) FOC72_RS00825 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC72_RS00835 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC72_RS00850 ENOG4105D2N Aldolase FOC72_RS00860 ENOG4108IUW ABC transporter FOC72_RS00895 ENOG4105VB9 50S ribosomal protein l28 FOC72_RS00915 ENOG4108M15 ABC transporter FOC72_RS00925 ENOG4105BZU Histidine kinase FOC72_RS00945 ENOG4108ZP8 Acetolactate synthase small subunit FOC72_RS00950 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC72_RS00955 ENOG4105C7B Threonine dehydratase FOC72_RS00970 ENOG4105CDA abc transporter atp-binding protein FOC72_RS00975 ENOG4105E5Q amino acid AbC transporter FOC72_RS00985 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC72_RS00990 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FOC72_RS00995 ENOG4105ESV Glycosyl transferase, family 4 FOC72_RS01005 ENOG4105JRK feS assembly protein SufD FOC72_RS01010 ENOG4105C9B Cysteine desulfurase FOC72_RS01015 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC72_RS01020 ENOG4105DIW FeS assembly protein SUFB FOC72_RS01035 ENOG4105DIB Oligopeptide-binding protein FOC72_RS01040 ENOG4105DIB Oligopeptide-binding protein FOC72_RS01050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC72_RS01055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC72_RS01060 ENOG4105C3U ABC transporter FOC72_RS01065 ENOG4108JQ7 (ABC) transporter FOC72_RS01095 ENOG4105CFH Aspartokinase FOC72_RS01100 ENOG4105CGU Enoyl-CoA hydratase FOC72_RS01105 ENOG4105NTK Transcriptional repressor Mpra FOC72_RS01110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC72_RS01125 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC72_RS01130 ENOG4105CHR reductase FOC72_RS01145 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOC72_RS01150 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC72_RS01155 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOC72_RS01160 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOC72_RS01180 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOC72_RS01185 ENOG4108Q5F Tetr family transcriptional regulator FOC72_RS01205 ENOG4105F3R pts system mannose fructose sorbose family iid FOC72_RS01210 ENOG4105ETZ PTS System FOC72_RS01225 ENOG4108KP7 hydrolase FOC72_RS01235 ENOG4105C7N Xanthine uracil vitamin C permease FOC72_RS01240 ENOG4105K8N protein family UPF0079, ATPase FOC72_RS01245 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC72_RS01250 ENOG4108KGH TRANSCRIPTIONal FOC72_RS01260 ENOG4105K59 histidine triad (HIT) protein FOC72_RS01280 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOC72_RS01285 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOC72_RS01290 ENOG4105CHV Transcription elongation factor NusA FOC72_RS01295 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC72_RS01305 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOC72_RS01310 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOC72_RS01315 ENOG4105CE4 GlcNAc 6-P deacetylase FOC72_RS01360 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOC72_RS01365 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOC72_RS01410 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOC72_RS01420 ENOG4105CJN penicillin-binding protein FOC72_RS01425 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOC72_RS01430 ENOG4105C1J atp-dependent rna helicase FOC72_RS01440 ENOG4105CDA abc transporter atp-binding protein FOC72_RS01450 ENOG4105C3M thioredoxin reductase FOC72_RS01455 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC72_RS01460 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FOC72_RS01465 ENOG4108Z9I -acetyltransferase FOC72_RS01470 ENOG4105CTZ aminopeptidase c FOC72_RS01475 ENOG4105BZ4 penicillin-binding protein FOC72_RS01480 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC72_RS01485 ENOG4108UKS UPF0398 protein FOC72_RS01490 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FOC72_RS01500 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC72_RS01505 ENOG41070VT FOC72_RS01510 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FOC72_RS01515 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FOC72_RS01520 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOC72_RS01525 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FOC72_RS01530 ENOG4105C25 Primosomal protein n' FOC72_RS01535 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOC72_RS01540 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC72_RS01545 ENOG4108ZF3 Phosphatase FOC72_RS01550 ENOG4105D9P serine threonine protein kinase FOC72_RS01560 ENOG4105ENE Histidine kinase FOC72_RS01575 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOC72_RS01585 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC72_RS01595 ENOG41081UC Inherit from COG: Competence protein FOC72_RS01680 ENOG4105EVI UPF0374 protein FOC72_RS01685 ENOG410902V Modulates RecA activity (By similarity) FOC72_RS01695 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC72_RS01700 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC72_RS01705 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC72_RS01710 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOC72_RS01745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC72_RS01750 ENOG4105NI8 Cytosine-specific methyltransferase FOC72_RS01765 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC72_RS01770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC72_RS01775 ENOG4105CI1 PTS System FOC72_RS01785 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOC72_RS01805 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOC72_RS01810 ENOG4105C0D helicase FOC72_RS01820 ENOG4105DFU Cell wall formation (By similarity) FOC72_RS01840 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC72_RS01850 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC72_RS01855 ENOG4105US7 Histidine kinase FOC72_RS01870 ENOG4108RWN rrna methyltransferase FOC72_RS01895 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC72_RS01900 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC72_RS01915 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC72_RS01920 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FOC72_RS01925 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOC72_RS01930 ENOG4105FE9 pseudouridine synthase FOC72_RS01935 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOC72_RS01945 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FOC72_RS01950 ENOG4105C1A potassium transporter peripheral membrane FOC72_RS01960 ENOG4108SAX Membrane FOC72_RS01965 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC72_RS01975 ENOG4105N5T Radical SAM Protein FOC72_RS02005 ENOG4108I0C methyltransferase FOC72_RS02020 ENOG4105DKW ABC transporter FOC72_RS02025 ENOG4105C02 permease FOC72_RS02035 ENOG4107414 GntR family transcriptional regulator FOC72_RS02040 ENOG4105C5Y PTS System FOC72_RS02045 ENOG4105CG3 alpha amylase, catalytic region FOC72_RS02055 ENOG4105F1A Pyruvate formate-lyase FOC72_RS02060 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FOC72_RS02080 ENOG4105EHG Permease protein FOC72_RS02085 ENOG4105DQ5 transport system permease protein FOC72_RS02090 ENOG4108HUF Transporter FOC72_RS02095 ENOG4105E0A ABC, transporter FOC72_RS02105 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC72_RS02115 ENOG4105C28 cystathionine FOC72_RS02120 ENOG4105C87 Aminotransferase class I and II FOC72_RS02130 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC72_RS02135 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOC72_RS02140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC72_RS02145 ENOG4105WUC UPF0298 protein FOC72_RS02150 ENOG4105CP9 extracellular ligand-binding receptor FOC72_RS02155 ENOG4105C32 Amino acid ABC transporter (Permease) FOC72_RS02160 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC72_RS02165 ENOG4105C0Z ABC transporter FOC72_RS02170 ENOG4108IV0 ABC, transporter FOC72_RS02175 ENOG41080XP Cbs domain FOC72_RS02180 ENOG4108JYZ YitT family FOC72_RS02185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOC72_RS02190 ENOG4105FA2 dna polymerase iii FOC72_RS02195 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) FOC72_RS02200 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC72_RS02205 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC72_RS02210 ENOG4108JQ1 Dehydrogenase FOC72_RS02215 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC72_RS02220 ENOG4105CSM endonuclease III FOC72_RS02230 ENOG4105CGK Exodeoxyribonuclease III FOC72_RS02245 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC72_RS02255 ENOG4105E98 transcriptional regulator DeoR family FOC72_RS02260 ENOG4105RSI Galactose-6-phosphate isomerase subunit LacA FOC72_RS02265 ENOG4108YZG isomerase FOC72_RS02270 ENOG4105DE4 1-phosphofructokinase FOC72_RS02275 ENOG4105D2M Aldolase FOC72_RS02280 ENOG4105CID antiterminator FOC72_RS02300 ENOG4105VMP Transcriptional regulator FOC72_RS02320 ENOG4105E3J oxidoreductase FOC72_RS02330 ENOG4105CJZ response regulator FOC72_RS02335 ENOG4105EWM Histidine kinase FOC72_RS02350 ENOG4105C19 ABC transporter FOC72_RS02370 ENOG4105DY9 regulatoR FOC72_RS02385 ENOG4105R8C Transcriptional regulator FOC72_RS02410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC72_RS02425 ENOG4105C19 ABC transporter FOC72_RS02435 ENOG4105CUB amino acid FOC72_RS02475 ENOG4105CHR reductase FOC72_RS02490 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOC72_RS02505 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC72_RS02515 ENOG4105C5H ABC transporter FOC72_RS02555 ENOG4108TIT dATP pyrophosphohydrolase FOC72_RS02560 ENOG41067S9 phage shock protein C, PspC FOC72_RS02565 ENOG4105CNU cell division protein FtsK FOC72_RS02570 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC72_RS02580 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOC72_RS02585 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOC72_RS02590 ENOG4105E5D amino acid FOC72_RS02595 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC72_RS02600 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOC72_RS02605 ENOG4105QNR S1 RNA binding domain protein FOC72_RS02610 ENOG4106E6V UPF0346 protein FOC72_RS02615 ENOG4105C9A Phoh family FOC72_RS02620 ENOG4105DCF alanine dehydrogenase FOC72_RS02625 ENOG41068WN FOC72_RS02635 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOC72_RS02640 ENOG4107YR5 Diacylglycerol kinase FOC72_RS02645 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC72_RS02650 ENOG4105CVR type I restriction-modification system FOC72_RS02685 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC72_RS02690 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC72_RS02695 ENOG4105C6X Major Facilitator FOC72_RS02700 ENOG410861F 50S ribosomal protein L33 FOC72_RS02710 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC72_RS02715 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOC72_RS02720 ENOG41088CC tellurite resistance protein tehB FOC72_RS02725 ENOG4105C9K Endothelin-converting enzyme 1 FOC72_RS02745 ENOG4105ST3 Transcriptional regulator FOC72_RS02750 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC72_RS02765 ENOG4108Z40 Transcriptional regulator FOC72_RS02770 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC72_RS02775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC72_RS02795 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FOC72_RS02800 ENOG4105DC7 peptidase M24 FOC72_RS02805 ENOG4105ETE Transcriptional regulator (LacI family FOC72_RS02810 ENOG4105W2C Glycosyl transferase FOC72_RS02815 ENOG4105BZF Glycosyl transferase (Group 1 FOC72_RS02830 ENOG4105C22 threonyL-tRNA synthetase FOC72_RS02840 ENOG4105DRP amino acid AbC transporter FOC72_RS02845 ENOG4105EAD ABC transporter FOC72_RS02850 ENOG4107RP9 extracellular solute-binding protein, family 3 FOC72_RS02855 ENOG4105CDA abc transporter atp-binding protein FOC72_RS02860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC72_RS02865 ENOG4105BZU Histidine kinase FOC72_RS02870 ENOG4105Q2H domain protein FOC72_RS02875 ENOG4105WD1 Membrane FOC72_RS02880 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOC72_RS02885 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC72_RS02890 ENOG4108HCJ Hydrolase FOC72_RS02895 ENOG410667J hydrolase FOC72_RS02900 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC72_RS02905 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC72_RS02910 ENOG4108NNR transporter substrate-binding protein FOC72_RS02915 ENOG4108PJD permease FOC72_RS02930 ENOG410906U SprT-like FOC72_RS02940 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC72_RS02945 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FOC72_RS02950 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FOC72_RS02975 ENOG4105CFP Peptidase U32 FOC72_RS02990 ENOG4105VEM Conserved domain protein FOC72_RS02995 ENOG4105VKD bioY protein FOC72_RS03000 ENOG4106IPI cyclase, family FOC72_RS03005 ENOG4105DC8 reductase FOC72_RS03010 ENOG4107X8C Efflux transporter RND family MFP subunit FOC72_RS03015 ENOG4105C19 ABC transporter FOC72_RS03020 ENOG4107RBB ABC transporter, permease FOC72_RS03025 ENOG4105CRK lysyL-tRNA synthetase FOC72_RS03030 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC72_RS03035 ENOG4108Z66 YbaK ebsC protein FOC72_RS03050 ENOG4108V06 Glutathione peroxidase FOC72_RS03055 ENOG4105CNI cell division protein FtsW FOC72_RS03060 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FOC72_RS03065 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOC72_RS03085 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FOC72_RS03120 ENOG4105K64 Glycosyl transferase, family 2 FOC72_RS03130 ENOG4105EY8 ABC transporter FOC72_RS03140 ENOG4107T7U Sulfatase FOC72_RS03160 ENOG4105CAT Cytidine monophosphate kinase FOC72_RS03170 ENOG4105VJV 50s ribosomal protein L35 FOC72_RS03175 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOC72_RS03180 ENOG4108UK2 deaminase FOC72_RS03190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOC72_RS03195 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC72_RS03225 ENOG4108U05 Transcriptional regulator FOC72_RS03235 ENOG4105WH5 Teichoic acid glycosylation protein FOC72_RS03240 ENOG410807C QueT transporter FOC72_RS03245 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC72_RS03250 ENOG4105CBD Diacylglycerol kinase FOC72_RS03255 ENOG4108IUM Glycogen debranching enzyme FOC72_RS03280 ENOG4105DR4 Methyltransferase FOC72_RS03285 ENOG4105FF2 Type I DHQase FOC72_RS03290 ENOG4105E2X shikimate dehydrogenase FOC72_RS03295 ENOG4105D49 3-dehydroquinate synthase FOC72_RS03300 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC72_RS03305 ENOG4105EVN Prephenate dehydrogenase FOC72_RS03310 ENOG4105WZB UPF0342 protein FOC72_RS03315 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOC72_RS03320 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC72_RS03325 ENOG4105CQC Prephenate dehydratase FOC72_RS03330 ENOG4108RCF TRANSCRIPTIONal FOC72_RS03335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC72_RS03360 ENOG4105CJ1 ABC, transporter FOC72_RS03370 ENOG4105BZ1 (ABC) transporter FOC72_RS03375 ENOG4108V15 phosphotransferase enzyme family FOC72_RS03380 ENOG4108IUK alpha amylase, catalytic FOC72_RS03405 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC72_RS03410 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC72_RS03420 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC72_RS03425 ENOG4107Z2D Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FOC72_RS03430 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC72_RS03435 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC72_RS03440 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC72_RS03445 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC72_RS03450 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC72_RS03455 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC72_RS03460 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOC72_RS03465 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FOC72_RS03480 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC72_RS03495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOC72_RS03500 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC72_RS03510 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC72_RS03515 ENOG4108IXY short-chain dehydrogenase reductase FOC72_RS03535 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC72_RS03540 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOC72_RS03545 ENOG4105CVG Homoserine O-transsuccinylase FOC72_RS03565 ENOG4105EGD dinuclear metal center protein, YbgI family FOC72_RS03570 ENOG4107VFR oxidoreductase FOC72_RS03575 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC72_RS03585 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC72_RS03595 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOC72_RS03605 ENOG4108Z7F N-acetyltransferase FOC72_RS03610 ENOG4106N3A copper homeostasis protein cutc FOC72_RS03615 ENOG4105UNS Pfam:DUF419 FOC72_RS03620 ENOG4105BZ1 (ABC) transporter FOC72_RS03625 ENOG4105BZ1 (ABC) transporter FOC72_RS03645 ENOG4108UT2 hemolysin iii FOC72_RS03660 ENOG4105D1Q UPF0246 protein FOC72_RS03705 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC72_RS03720 ENOG4105CHM Aminotransferase FOC72_RS03750 ENOG4105C5S asparaginyl-tRNA synthetase FOC72_RS03765 ENOG4105BZ1 (ABC) transporter FOC72_RS03770 ENOG4105C5H ABC transporter FOC72_RS03795 ENOG4108A04 Beta-lactamase FOC72_RS03805 ENOG4105GBT ABC transporter FOC72_RS03820 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC72_RS03850 ENOG4108Z4K mutator MutT protein FOC72_RS03865 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC72_RS03880 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FOC72_RS03890 ENOG4105CXT aspartate transcarbamylase FOC72_RS03895 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC72_RS03900 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC72_RS03905 ENOG4105DSE periplasmic solute binding protein FOC72_RS03920 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC72_RS03955 ENOG410667J hydrolase FOC72_RS03960 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOC72_RS03985 ENOG41086D8 Transcriptional regulator FOC72_RS03990 ENOG41079CX FOC72_RS04000 ENOG4105K5M 30s ribosomal protein S16 FOC72_RS04005 ENOG4105VB6 UPF0109 protein FOC72_RS04015 ENOG4105CZN Potassium uptake protein FOC72_RS04020 ENOG4107ZYR domain protein FOC72_RS04045 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FOC72_RS04050 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOC72_RS04060 ENOG4105EG2 ABC transporter, permease FOC72_RS04075 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC72_RS04150 ENOG4107QSE Dipeptidase FOC72_RS04155 ENOG4108RG0 uracil-dna glycosylase FOC72_RS04165 ENOG4105CPQ Dehydrogenase FOC72_RS04175 ENOG4108VXD carboxy-peptidase FOC72_RS04190 ENOG41082DI 50s ribosomal protein l31 FOC72_RS04195 ENOG4105SFS phosphoesterase RecJ domain protein FOC72_RS04220 ENOG4106A8V Protein CrcB homolog FOC72_RS04225 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOC72_RS04250 ENOG4108V16 CRISPR-associated protein FOC72_RS04255 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC72_RS04260 ENOG4105E66 phosphoriboisomerase A FOC72_RS04265 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FOC72_RS04280 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FOC72_RS04310 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FOC72_RS04315 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FOC72_RS04320 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FOC72_RS04325 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOC72_RS04340 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOC72_RS04345 ENOG4108Z4K mutator MutT protein FOC72_RS04355 ENOG4105CGH 5'-nucleotidase FOC72_RS04360 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC72_RS04365 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC72_RS04385 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC72_RS04390 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC72_RS04395 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC72_RS04415 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOC72_RS04430 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC72_RS04435 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC72_RS04440 ENOG4108Z6X (sortase) family FOC72_RS04445 ENOG4105W5Q DNA repair protein (RadC FOC72_RS04470 ENOG4105C3J Cysteine desulfurase FOC72_RS04475 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC72_RS04490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC72_RS04495 ENOG4105EMS pseudouridine synthase FOC72_RS04500 ENOG4108IJ2 phosphate acetyltransferase FOC72_RS04505 ENOG4105CEN a g-specific adenine glycosylase FOC72_RS04520 ENOG4105FH5 Membrane FOC72_RS04525 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC72_RS04535 ENOG4105CKU formyltetrahydrofolate synthetase FOC72_RS04540 ENOG4107Y3V -acetyltransferase FOC72_RS04555 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC72_RS04560 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC72_RS04575 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC72_RS04580 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC72_RS04585 ENOG4105CID antiterminator FOC72_RS04590 ENOG4108UW5 maltose o-acetyltransferase FOC72_RS04595 ENOG4105C79 DNA protecting protein DprA FOC72_RS04600 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC72_RS04605 ENOG410907G FOC72_RS04610 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FOC72_RS04635 ENOG4107RUY (E1 component), alpha subunit FOC72_RS04640 ENOG4105CPP Dehydrogenase, E1 component FOC72_RS04645 ENOG4107QKR Dehydrogenase FOC72_RS04655 ENOG4105DF9 Lipoate-protein, ligase FOC72_RS04665 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC72_RS04680 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FOC72_RS04720 ENOG41065S2 pneumococcal vaccine antigen FOC72_RS04730 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC72_RS04740 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC72_RS04745 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC72_RS04750 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC72_RS04755 ENOG4107104 thymidine kinase FOC72_RS04760 ENOG41069HH 4-oxalocrotonate tautomerase FOC72_RS04765 ENOG4105CS2 ec 3.2.1.21 FOC72_RS04770 ENOG4105CK1 PTS System FOC72_RS04775 ENOG4105VZJ PTS System FOC72_RS04780 ENOG4105VCP PTS System FOC72_RS04795 ENOG4105UQX Mate efflux family protein FOC72_RS04800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC72_RS04805 ENOG4107QKR Dehydrogenase FOC72_RS04815 ENOG4107RUY (E1 component), alpha subunit FOC72_RS04830 ENOG4107QMU Mate efflux family protein FOC72_RS04835 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FOC72_RS04840 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOC72_RS04845 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC72_RS04850 ENOG4107SJW iron permease, FTR1 FOC72_RS04855 ENOG4105DBE peroxidase FOC72_RS04860 ENOG410650H (LipO)protein FOC72_RS04865 ENOG4105CMQ Chloride channel FOC72_RS04885 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FOC72_RS04890 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC72_RS04895 ENOG4107QIV Cytochrome c biogenesis protein FOC72_RS04900 ENOG4105C2F Histidine kinase FOC72_RS04905 ENOG4105EQD regulatoR FOC72_RS04910 ENOG4105E0X reductase FOC72_RS04925 ENOG4107QIV Cytochrome c biogenesis protein FOC72_RS04930 ENOG4105CWM branched-chain amino acid transport system II carrier protein FOC72_RS04960 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOC72_RS04965 ENOG4108VZM 50s ribosomal protein L10 FOC72_RS04980 ENOG4105TMB Formate nitrite transporter FOC72_RS04985 ENOG4108J5H Homocysteine s-methyltransferase FOC72_RS04990 ENOG4107X35 defense response to bacterium FOC72_RS04995 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOC72_RS05000 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOC72_RS05005 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOC72_RS05010 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOC72_RS05015 ENOG4105DKQ ROK family FOC72_RS05025 ENOG4105C5H ABC transporter FOC72_RS05030 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOC72_RS05035 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOC72_RS05040 ENOG4105EPR degv family FOC72_RS05050 ENOG4105DM4 PTS System FOC72_RS05055 ENOG4105DE4 1-phosphofructokinase FOC72_RS05060 ENOG4105E98 transcriptional regulator DeoR family FOC72_RS05065 ENOG4108TYN CAAX amino terminal protease family protein FOC72_RS05075 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC72_RS05085 ENOG4105CSA Coproporphyrinogen iii oxidase FOC72_RS05100 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOC72_RS05105 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC72_RS05110 ENOG4105C34 Pseudouridine synthase FOC72_RS05120 ENOG4105DUM transcriptional regulator, lysR family FOC72_RS05130 ENOG4105DIB Oligopeptide-binding protein FOC72_RS05135 ENOG4105D17 glycoside hydrolase, family 3 domain protein FOC72_RS05150 ENOG4105K46 50S ribosomal protein l27 FOC72_RS05160 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOC72_RS05170 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FOC72_RS05175 ENOG4105C3J Cysteine desulfurase FOC72_RS05180 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FOC72_RS05185 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FOC72_RS05195 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC72_RS05205 ENOG4108HM4 ABC transporter FOC72_RS05210 ENOG4105D38 putrescine abc transporter FOC72_RS05215 ENOG4105D56 permease protein FOC72_RS05220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC72_RS05225 ENOG4105D4A Cell wall formation (By similarity) FOC72_RS05230 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOC72_RS05235 ENOG4105D6E homoserine dehydrogenase FOC72_RS05250 ENOG4105UIB (ABC) transporter FOC72_RS05255 ENOG4108JQ9 ABC transporter FOC72_RS05260 ENOG4105DIH basic membrane FOC72_RS05265 ENOG4105KG3 cytidine deaminase FOC72_RS05270 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FOC72_RS05275 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC72_RS05280 ENOG4107Y49 methyltransferase FOC72_RS05285 ENOG4105CS9 pantothenic acid kinase FOC72_RS05290 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FOC72_RS05330 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC72_RS05350 ENOG4105DER m42 family FOC72_RS05365 ENOG4105MYU Immunoglobulin A1 protease FOC72_RS05365 ENOG4105MYU Immunoglobulin A1 protease FOC72_RS05385 ENOG4105DJ4 phosphatidylserine decarboxylase FOC72_RS05390 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC72_RS05405 ENOG4105CMR udp-glucose 4-epimerase FOC72_RS05415 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOC72_RS05420 ENOG4105CQ4 Transcriptional regulator FOC72_RS05425 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FOC72_RS05435 ENOG4105C6E dna polymerase iii FOC72_RS05445 ENOG4108J2P Alpha beta hydrolase fold FOC72_RS05455 ENOG41067QW Transcriptional regulator FOC72_RS05460 ENOG4107XNU peptidase FOC72_RS05495 ENOG4105E90 ABC transporter FOC72_RS05510 ENOG4105K56 Transcriptional regulator FOC72_RS05520 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FOC72_RS05530 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC72_RS05535 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC72_RS05585 ENOG4105DBI uridine monophosphokinase FOC72_RS05600 ENOG4108ZJ4 polysaccharide deacetylase FOC72_RS05615 ENOG4105US7 Histidine kinase FOC72_RS05620 ENOG4108STX response regulator FOC72_RS05660 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC72_RS05665 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC72_RS05670 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC72_RS05675 ENOG4105E2Z phosphate ABC transporter (Permease FOC72_RS05680 ENOG4105C8U phosphate abc transporter FOC72_RS05685 ENOG4105CVA phosphate FOC72_RS05690 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC72_RS05695 ENOG4105ECY inositol monophosphatase FOC72_RS05700 ENOG4105WBI UPF0223 protein FOC72_RS05705 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FOC72_RS05710 ENOG4105DTN riboflavin biosynthesis protein ribF FOC72_RS05715 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC72_RS05745 ENOG4105BZ1 (ABC) transporter FOC72_RS05765 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC72_RS05770 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC72_RS05785 ENOG4105E2A Dehydrogenase FOC72_RS05815 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC72_RS05875 ENOG4107FQX Alpha-acetolactate decarboxylase FOC72_RS05890 ENOG4105BZU Histidine kinase FOC72_RS05900 ENOG4107RBB ABC transporter, permease FOC72_RS05905 ENOG4105C19 ABC transporter FOC72_RS05920 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC72_RS05930 ENOG4105CJW magnesium transporter FOC72_RS05935 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOC72_RS05950 ENOG4105BZW Glycerate kinase FOC72_RS05955 ENOG4105EAC phosphoserine phosphatase FOC72_RS05960 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FOC72_RS05965 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC72_RS05975 ENOG4107S0N DJ-1 family FOC72_RS05985 ENOG4105HMI Membrane FOC72_RS05990 ENOG4105DVT helicase FOC72_RS06000 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC72_RS06005 ENOG4105CAK Cell division ATP-binding protein ftsE FOC72_RS06035 ENOG4105DCI Phosphohydrolase FOC72_RS06045 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) FOC72_RS06065 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC72_RS06075 ENOG4105CKK Glycosyl transferase, family 2 FOC72_RS06085 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC72_RS06090 ENOG4105C4R Atp-dependent dna helicase FOC72_RS06110 ENOG4105CA9 Pyruvate kinase FOC72_RS06115 ENOG4105CTQ phosphohexokinase FOC72_RS06125 ENOG4105CZV ABC transporter FOC72_RS06135 ENOG41067MG lrgb family FOC72_RS06155 ENOG4105EDE A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity) FOC72_RS06160 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FOC72_RS06185 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of FOC72_RS06190 ENOG4105GH9 galactofuranosyltransferase FOC72_RS06220 ENOG4105VG1 fes assembly suf system protein FOC72_RS06225 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC72_RS06230 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC72_RS06235 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FOC72_RS06240 ENOG4105VCC 30S ribosomal protein S21 FOC72_RS06265 ENOG4105KA3 membrAne FOC72_RS06270 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC72_RS06275 ENOG4105CAY ferredoxin--nadp reductase FOC72_RS06280 ENOG4105CIE May be required for sporulation (By similarity) FOC72_RS06285 ENOG4105CHW UPF0052 protein FOC72_RS06290 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOC72_RS06295 ENOG4105KME endoribonuclease L-psp FOC72_RS06305 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC72_RS06320 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOC72_RS06330 ENOG4105C8B TIGR00159 family FOC72_RS06335 ENOG4105DMS mur ligase FOC72_RS06340 ENOG4105F1K Glutamine amidotransferase FOC72_RS06365 ENOG4105C5H ABC transporter FOC72_RS06380 ENOG4105ZT7 DNA-entry nuclease FOC72_RS06390 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC72_RS06400 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOC72_RS06405 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FOC72_RS06410 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOC72_RS06415 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOC72_RS06420 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC72_RS06425 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FOC72_RS06430 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC72_RS06435 ENOG4105ZA1 atp synthase FOC72_RS06440 ENOG4105DG6 mannose-6-phosphate isomerase FOC72_RS06455 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC72_RS06465 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC72_RS06470 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOC72_RS06475 ENOG4105C26 Dehydrogenase FOC72_RS06480 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC72_RS06485 ENOG4105KRI phosphocarrier protein (HPr FOC72_RS06490 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FOC72_RS06495 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC72_RS06500 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC72_RS06505 ENOG4106ZEE Diacylglycerol kinase FOC72_RS06530 ENOG4105VZ8 Transcriptional regulator FOC72_RS06540 ENOG4105C8Y Acetylornithine aminotransferase FOC72_RS06545 ENOG4105CAS nag kinase FOC72_RS06550 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC72_RS06555 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOC72_RS06560 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC72_RS06570 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC72_RS06640 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FOC72_RS06650 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOC72_RS06655 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC72_RS06660 ENOG4107QSE Dipeptidase FOC72_RS06665 ENOG4105CSX c4-dicarboxylate anaerobic carrier FOC72_RS06670 ENOG4105C5B carbamate kinase FOC72_RS06680 ENOG4105CEU Arginine dihydrolase FOC72_RS06695 ENOG41082BM Transcriptional regulator, arsr family FOC72_RS06700 ENOG41090T1 Membrane FOC72_RS06710 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC72_RS06725 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC72_RS06730 ENOG4105KQC Competence protein FOC72_RS06740 ENOG4105F6E Acyl-transferase FOC72_RS06745 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC72_RS06750 ENOG41060K3 Methyltransferase FOC72_RS06755 ENOG4105VC4 domain protein FOC72_RS06765 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase FOC72_RS06770 ENOG4105E98 transcriptional regulator DeoR family FOC72_RS06775 ENOG4105C1J atp-dependent rna helicase FOC72_RS06785 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC72_RS06790 ENOG4105BZN citrate synthase FOC72_RS06795 ENOG4108I0Z Aconitate hydratase FOC72_RS06805 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOC72_RS06825 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC72_RS06830 ENOG4105CPF Cell wall formation (By similarity) FOC72_RS06835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FOC72_RS06840 ENOG4107RF6 penicillin-binding protein FOC72_RS06845 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC72_RS06855 ENOG4105G5W regulator Fur family FOC72_RS06870 ENOG4105K70 DNA-binding protein FOC72_RS06875 ENOG4108RCR degv family FOC72_RS06880 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC72_RS06885 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC72_RS06890 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC72_RS06895 ENOG4105DX0 Hemolysin A FOC72_RS06905 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOC72_RS06910 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOC72_RS06915 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FOC72_RS06920 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOC72_RS06925 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC72_RS06930 ENOG4107IN1 Protein of unknown function (DUF1797) FOC72_RS06935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC72_RS06945 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC72_RS06970 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC72_RS06975 ENOG4105MMF Cell division protein DIVIVA FOC72_RS06990 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FOC72_RS06995 ENOG4105DFA alanine racemase domain protein FOC72_RS07000 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC72_RS07010 ENOG4105U2C Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC72_RS07015 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC72_RS07020 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOC72_RS07030 ENOG4105CI3 gtp-binding protein typa FOC72_RS07075 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOC72_RS07085 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FOC72_RS07090 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOC72_RS07095 ENOG4108I0Q anthranilate phosphoribosyltransferase FOC72_RS07100 ENOG4105DDQ anthranilate synthase FOC72_RS07105 ENOG4105CRQ synthase (Component I) FOC72_RS07110 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOC72_RS07120 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOC72_RS07125 ENOG4105MMD transcriptional regulator FOC72_RS07130 ENOG41063PX domain protein FOC72_RS07135 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOC72_RS07140 ENOG4106H78 methyltransferase FOC72_RS07150 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC72_RS07155 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC72_RS07170 ENOG4107S78 Band 7 protein FOC72_RS07180 ENOG4105WT3 Transcriptional regulator FOC72_RS07195 ENOG4105WT3 Transcriptional regulator FOC72_RS07205 ENOG4105D0M Protease HtpX homolog FOC72_RS07210 ENOG4108V0P LemA family FOC72_RS07230 ENOG4105C19 ABC transporter FOC72_RS07235 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FOC72_RS07250 ENOG4108JJB ABC transporter FOC72_RS07285 ENOG4105C72 UPF0176 protein FOC72_RS07305 ENOG4108V7D UPF0397 protein FOC72_RS07310 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase FOC72_RS07325 ENOG4105EAB amino acid AbC transporter FOC72_RS07330 ENOG4105CH2 amidohydrolase FOC72_RS07335 ENOG4105CDY transcriptional regulatory protein FOC72_RS07350 ENOG4105CDE UPF0348 protein FOC72_RS07355 ENOG4105DXX methyltransferase FOC72_RS07360 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOC72_RS07365 ENOG4108W2Y isochorismatase FOC72_RS07370 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC72_RS07375 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOC72_RS07380 ENOG410812S Rna-binding protein FOC72_RS07385 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC72_RS07390 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC72_RS07435 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC72_RS07440 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC72_RS07445 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC72_RS07460 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FOC72_RS07470 ENOG4105CHM Aminotransferase FOC72_RS07530 ENOG4107RB3 L-asparaginase FOC72_RS07535 ENOG4105CB5 ATP-dependent DNA helicase recG FOC72_RS07540 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC72_RS07545 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOC72_RS07550 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOC72_RS07555 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOC72_RS07560 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC72_RS07565 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC72_RS07570 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC72_RS07585 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FOC72_RS07590 ENOG4108ZFT Dehydratase small subunit FOC72_RS07595 ENOG4105YCI dehydratase medium subunit FOC72_RS07600 ENOG4105DMB glycerol dehydratase FOC72_RS07605 ENOG4105EHR propanediol utilization protein pduB FOC72_RS07610 ENOG4105NDK ethanolamine utilization protein FOC72_RS07615 ENOG4105ENY Ethanolamine utilization protein eutH FOC72_RS07630 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) FOC72_RS07640 ENOG4105KNY Microcompartments protein FOC72_RS07645 ENOG4105KNY Microcompartments protein FOC72_RS07650 ENOG4105C0A alcohol dehydrogenase FOC72_RS07655 ENOG4105KNY Microcompartments protein FOC72_RS07660 ENOG4106D67 ethanolamine utilization protein FOC72_RS07665 ENOG4107FQ9 ethanolamine ammonia-lyase FOC72_RS07670 ENOG4105CPD ethanolamine ammonia-lyase FOC72_RS07675 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FOC72_RS07690 ENOG4105M3W utilization protein FOC72_RS07700 ENOG4108WBT adenosyltransferase FOC72_RS07705 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FOC72_RS07710 ENOG4105JZC GHMP kinase FOC72_RS07715 ENOG4107QZB decarboxylase FOC72_RS07735 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC72_RS07750 ENOG4105C3U ABC transporter FOC72_RS07755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC72_RS07760 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC72_RS07765 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC72_RS07770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC72_RS07785 ENOG4108JQ5 ABC transporter FOC72_RS07790 ENOG4105C3U ABC transporter FOC72_RS07795 ENOG4107RRN ABC transporter substrate-binding protein FOC72_RS07800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC72_RS07805 ENOG4105CVJ phosphoglycerate mutase FOC72_RS07810 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FOC72_RS07815 ENOG4108YZT Adenosylcobinamide kinase FOC72_RS07820 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOC72_RS07825 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC72_RS07835 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOC72_RS07840 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FOC72_RS07845 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC72_RS07850 ENOG4108WBT adenosyltransferase FOC72_RS07855 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FOC72_RS07860 ENOG4108JJB ABC transporter FOC72_RS07875 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FOC72_RS07880 ENOG4105DVK Precorrin-2 c20-methyltransferase FOC72_RS07885 ENOG4107PPM cobalt chelatase FOC72_RS07895 ENOG4108JTQ reductase FOC72_RS07900 ENOG4105E4R Precorrin-3B C17-methyltransferase FOC72_RS07905 ENOG4108P62 biosynthesis protein (CbiG) FOC72_RS07910 ENOG4105CIA precorrin-4 C(11)-methyltransferase FOC72_RS07915 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase FOC72_RS07920 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase FOC72_RS07925 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FOC72_RS07930 ENOG41081F0 Precorrin-8x methylmutase FOC72_RS07935 ENOG41081F0 Precorrin-8x methylmutase FOC72_RS07940 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FOC72_RS07945 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FOC72_RS07950 ENOG4105BZ1 (ABC) transporter FOC72_RS07960 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) FOC72_RS07965 ENOG4107YDN peptide deformylase FOC72_RS07970 ENOG4105EVU fructokinase FOC72_RS07975 ENOG4105C5Y PTS System FOC72_RS07985 ENOG4105ETE Transcriptional regulator (LacI family FOC72_RS07990 ENOG4108IUM Glycogen debranching enzyme FOC72_RS08005 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOC72_RS08010 ENOG4105DC7 peptidase M24 FOC72_RS08015 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC72_RS08040 ENOG4105CJ1 ABC, transporter FOC72_RS08045 ENOG4107XI7 Tetr family transcriptional regulator FOC72_RS08050 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOC72_RS08055 ENOG4108UUM single-stranded DNA-binding protein FOC72_RS08060 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOC72_RS08065 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC72_RS08070 ENOG4105CGP Urocanate hydratase FOC72_RS08075 ENOG4105CCS Glutamate formiminotransferase FOC72_RS08080 ENOG410908R Methenyltetrahydrofolate cyclohydrolase FOC72_RS08085 ENOG4105CKU formyltetrahydrofolate synthetase FOC72_RS08095 ENOG4105CUB amino acid FOC72_RS08100 ENOG4105C84 Histidine ammonia-lyase FOC72_RS08105 ENOG4105CYW agmatinase FOC72_RS08135 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC72_RS08140 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC72_RS08155 ENOG4108R6W Transcriptional regulator, ARAC family FOC72_RS08160 ENOG4105SYT Methylenetetrahydrofolate reductase FOC72_RS08165 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOC72_RS08235 ENOG4105ES5 Histidine kinase FOC72_RS08240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC72_RS08245 ENOG4105CS2 ec 3.2.1.21 FOC72_RS08255 ENOG4108IJ6 ABC transporter FOC72_RS08265 ENOG4105C7K acetolactate synthase FOC72_RS08275 ENOG4108HCJ Hydrolase FOC72_RS08280 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOC72_RS08290 ENOG4108IJ7 Glycine betaine FOC72_RS08310 ENOG4108W3Q Transcriptional regulator FOC72_RS08325 ENOG4105C5Y PTS System FOC72_RS08330 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FOC72_RS08335 ENOG4108UMI ABC transporter, permease FOC72_RS08340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC72_RS08345 ENOG4105D01 (LipO)protein FOC72_RS08350 ENOG4105E0X reductase FOC72_RS08355 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FOC72_RS08360 ENOG4107R37 Glutamate dehydrogenase FOC72_RS08365 ENOG4108MJ3 acetyltransferase FOC72_RS08390 ENOG4105D8X mechanosensitive ion channel FOC72_RS08400 ENOG4105BZG amino acid carrier protein FOC72_RS08405 ENOG4105K63 Thioredoxin FOC72_RS08415 ENOG4105C98 muts2 protein FOC72_RS08435 ENOG4105C3F Signal peptidase i FOC72_RS08440 ENOG4105C7H Helicase, RecD TraA family FOC72_RS08445 ENOG4108RZE Tetr family transcriptional regulator FOC72_RS08465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC72_RS08470 ENOG4105C6N Formate acetyltransferase FOC72_RS08485 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FOC72_RS08495 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOC72_RS08515 ENOG4107S1E Beta-lactamase FOC72_RS08530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC72_RS08535 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC72_RS08545 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FOC72_RS08550 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC72_RS08560 ENOG4105CBX hi0933 family FOC72_RS08565 ENOG4107TXC Transcriptional regulator FOC72_RS08570 ENOG4105DVA methyltransferase FOC72_RS08585 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC72_RS08595 ENOG41072GX Peptidase M22 Glycoprotease FOC72_RS08610 ENOG4106EHS UPF0356 protein FOC72_RS08625 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC72_RS08635 ENOG4105C5F glutamine synthetase FOC72_RS08640 ENOG4105KV4 Transcriptional regulator FOC72_RS08650 ENOG41068JE domain protein FOC72_RS08660 ENOG4105BZA Phosphoglycerate kinase FOC72_RS08670 ENOG4108ZX5 transcriptional regulator FOC72_RS08675 ENOG4105E1F short-chain dehydrogenase reductase FOC72_RS08685 ENOG4105ETE Transcriptional regulator (LacI family FOC72_RS08695 ENOG4105C8T Leucyl-tRNA synthetase FOC72_RS08720 ENOG4105CK1 PTS System FOC72_RS08725 ENOG4105VZJ PTS System FOC72_RS08730 ENOG4105VCP PTS System FOC72_RS08740 ENOG4107RHR regulatoR FOC72_RS08745 ENOG4105N2W Transcriptional regulator FOC72_RS08750 ENOG4105F1A Pyruvate formate-lyase FOC72_RS08770 ENOG4107RGM aldo keto reductase FOC72_RS08780 ENOG4105CK1 PTS System FOC72_RS08785 ENOG4105VCP PTS System FOC72_RS08790 ENOG4105VZJ PTS System FOC72_RS08795 ENOG4108NZE NAGC-like transcriptional regulator FOC72_RS08805 ENOG4105C9K Endothelin-converting enzyme 1 FOC72_RS08810 ENOG4105DIK (ABC) transporter FOC72_RS08815 ENOG4105CC5 ABC transporter FOC72_RS08820 ENOG4105DSE periplasmic solute binding protein FOC72_RS08825 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC72_RS08845 ENOG4105RV9 Transcriptional regulator FOC72_RS08850 ENOG4105M5P UPF0310 protein FOC72_RS08865 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOC72_RS08895 ENOG4105CGH 5'-nucleotidase FOC72_RS08900 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC72_RS08925 ENOG4105D1H recombination factor protein RarA FOC72_RS08955 ENOG41067QW Transcriptional regulator FOC72_RS08985 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOC72_RS08990 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOC72_RS09000 ENOG4105F3R pts system mannose fructose sorbose family iid FOC72_RS09005 ENOG4105ETZ PTS System FOC72_RS09025 ENOG4105WH1 Two component transcriptional regulator luxr family FOC72_RS09030 ENOG4105BZU Histidine kinase FOC72_RS09050 ENOG4108VDD TRNA binding domain protein FOC72_RS09065 ENOG4105CN9 Peptidase m42 family protein FOC72_RS09070 ENOG4105DPH UPF0371 protein FOC72_RS09120 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC72_RS09125 ENOG4105EUJ GTP cyclohydrolase i FOC72_RS09130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC72_RS09135 ENOG4105EEI dihydropteroate synthase FOC72_RS09150 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC72_RS09205 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FOC72_RS09210 ENOG4107R8N Glycosyl transferase, family 2 FOC72_RS09225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC72_RS09230 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC72_RS09235 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC72_RS09250 ENOG4105DHI Methyltransferase FOC72_RS09345 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC72_RS09385 ENOG4108IJ9 (ABC) transporter FOC72_RS09420 ENOG4105NA0 Transcriptional regulator FOC72_RS09425 ENOG4105DSE periplasmic solute binding protein FOC72_RS09435 ENOG4105FDK ABC transporter FOC72_RS09440 ENOG41067TZ transcriptional regulator, MarR family FOC72_RS09530 ENOG4108ZT0 50S ribosomal protein l17 FOC72_RS09535 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC72_RS09540 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOC72_RS09545 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOC72_RS09555 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOC72_RS09560 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOC72_RS09565 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC72_RS09570 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOC72_RS09575 ENOG4105VPB 50S ribosomal protein L30 FOC72_RS09580 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOC72_RS09585 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOC72_RS09590 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC72_RS09595 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOC72_RS09600 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOC72_RS09605 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FOC72_RS09610 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FOC72_RS09615 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOC72_RS09620 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOC72_RS09625 ENOG41082SA 50s ribosomal protein l29 FOC72_RS09630 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOC72_RS09635 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOC72_RS09640 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOC72_RS09645 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOC72_RS09650 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOC72_RS09655 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOC72_RS09660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FOC72_RS09665 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FOC72_RS09670 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FOC72_RS09680 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOC72_RS09695 ENOG4105K4P CoA-binding domain protein FOC72_RS09700 ENOG4105C2M dna polymerase I FOC72_RS09725 ENOG4105D98 threonine synthase FOC72_RS09735 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOC72_RS09740 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) FOC72_RS09745 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) FOC72_RS09755 ENOG4105KXQ Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOC72_RS09800 ENOG4107SCR N-acetylneuraminate lyase FOC72_RS09805 ENOG4105CK5 oxidoreductase FOC72_RS09810 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FOC72_RS09815 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC72_RS09825 ENOG4108R66 Conserved Protein FOC72_RS09830 ENOG4108IJ9 (ABC) transporter FOC72_RS09835 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FOC72_RS09840 ENOG4105I82 acetyl xylan esterase FOC72_RS09850 ENOG4105C0A alcohol dehydrogenase FOC72_RS09895 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOC72_RS09900 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FOC72_RS09905 ENOG4105D2M Aldolase FOC72_RS09910 ENOG4105E70 isomerase FOC72_RS09920 ENOG4105F3R pts system mannose fructose sorbose family iid FOC72_RS09925 ENOG4105ETZ PTS System FOC72_RS09930 ENOG4108IQ3 PTS system FOC72_RS09940 ENOG4105FDP GntR family transcriptional regulator FOC72_RS09945 ENOG4105VDH Dihydroxyacetone kinase FOC72_RS09950 ENOG4108UTZ Dihydroxyacetone kinase FOC72_RS09955 ENOG4105CMT Dihydroxyacetone kinase FOC72_RS09965 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC72_RS09970 ENOG4105C83 adenylosuccinate lyase FOC72_RS10005 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC72_RS10010 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC72_RS10020 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC72_RS10040 ENOG41068JE domain protein FOC72_RS10055 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC72_RS10060 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOC72_RS10065 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FOC72_RS10070 ENOG4107QIK phosphoribosylformylglycinamidine synthase FOC72_RS10075 ENOG4105C8V SAICAR synthetase FOC72_RS10080 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOC72_RS10085 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FOC72_RS10090 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) FOC72_RS10095 ENOG4105CHM Aminotransferase FOC72_RS10100 ENOG4105KFN sortase, SrtB family FOC72_RS10110 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC72_RS10115 ENOG41068JE domain protein FOC72_RS10250 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC72_RS10255 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC72_RS10260 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC72_RS10275 ENOG41082I2 s4 domain protein FOC72_RS10280 ENOG4108JA2 transcriptioN-repair coupling factor FOC72_RS10285 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC72_RS10290 ENOG4105C3G gtp-binding protein FOC72_RS10305 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC72_RS10315 ENOG4105FA0 parb-like partition protein FOC72_RS10320 ENOG4105C0H protease FOC72_RS10325 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOC72_RS10365 ENOG4105C5H ABC transporter FOC72_RS10370 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC72_RS10375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC72_RS10380 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC72_RS10405 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC72_RS10410 ENOG4108JJB ABC transporter FOC72_RS10415 ENOG4108JJB ABC transporter FOC72_RS10420 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC72_RS10435 ENOG4105EJQ L-serine dehydratase FOC72_RS10445 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC72_RS10450 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FOC72_RS10455 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FOC72_RS10465 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOC72_RS10470 ENOG4105CDU Replicative dna helicase FOC72_RS10480 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FOC72_RS10485 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FOC72_RS10500 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOC72_RS10505 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC72_RS10520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC72_RS10540 ENOG4105ECB domain protein FOC72_RS10590 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC72_RS10595 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FOC72_RS10600 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC72_RS10615 ENOG4105E98 transcriptional regulator DeoR family FOC72_RS10625 ENOG4108VX5 3-methyladenine DNA glycosylase FOC72_RS10630 ENOG4105DJ2 Major Facilitator Superfamily FOC72_RS10640 ENOG4105PGM cation diffusion facilitator family transporter FOC72_RS10645 ENOG4107QHF type ii secretion system protein e FOC72_RS10650 ENOG4105CZX twitching motility protein FOC72_RS10720 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FOC72_RS10740 ENOG41063PX domain protein FOC72_RS10775 ENOG41086FC 50S ribosomal protein l32 FOC72_RS10780 ENOG4105C01 Dihydroxy-acid dehydratase FOC72_RS10785 ENOG4105VG1 fes assembly suf system protein FOC72_RS10790 ENOG4105CUT histidyl-tRNA synthetase FOC72_RS10870 ENOG4107AYK membrAne FOC72_RS10875 ENOG4108IUM Glycogen debranching enzyme FOC72_RS10880 ENOG4105FKQ transcriptional regulator FOC72_RS10885 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) FOC72_RS10890 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FOC72_RS10900 ENOG4105MTF NrdI protein FOC72_RS10905 ENOG4105C75 arginyL-tRNA synthetase FOC72_RS10910 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC72_RS10915 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOC72_RS10930 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOC72_RS10940 ENOG41067QW Transcriptional regulator FOC72_RS10945 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOC72_RS10950 ENOG4108R3E Dna-3-methyladenine glycosylase i FOC72_RS10970 ENOG4105C19 ABC transporter FOC72_RS10985 ENOG4105CEV competence damage-inducible protein FOC72_RS10990 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOC72_RS10995 ENOG410888K transcriptional regulator, Spx FOC72_RS11010 ENOG4105VBH UPF0297 protein FOC72_RS11015 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FOC72_RS11020 ENOG4105VPH UPF0473 protein FOC72_RS11025 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC72_RS11035 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC72_RS11050 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC72_RS11070 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FOC72_RS11080 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC72_RS11105 ENOG4105CMR udp-glucose 4-epimerase FOC72_RS11110 ENOG4108RYC glycosyltransferase FOC72_RS11120 ENOG4105KPE licD family FOC72_RS11130 ENOG4107XDJ Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC72_RS11150 ENOG4108YBP pseudouridine synthase FOC72_RS11155 ENOG4105BZ4 penicillin-binding protein FOC72_RS11190 ENOG4105CE9 30S ribosomal protein S2 FOC72_RS11195 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FOC72_RS11205 ENOG4105KEX transcriptional regulator, ctsr FOC72_RS11250 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC72_RS11255 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOC72_RS11275 ENOG4105D9M gamma-glutamylcysteine synthetase FOC72_RS11280 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC72_RS11295 ENOG4107QYV phosphohexose isomerase FOC72_RS11300 ENOG4105CHR reductase FOC72_RS11305 ENOG4105EMD TRANSCRIPTIONal FOC72_RS11315 ENOG410787A Pts system, glucitol sorbitol-specific FOC72_RS11320 ENOG4105DZY Pts system, glucitol sorbitol-specific FOC72_RS11365 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FOC72_RS11370 ENOG4105CH2 amidohydrolase FOC72_RS11375 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC72_RS11385 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC72_RS11390 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOC72_RS11395 ENOG4105BZ1 (ABC) transporter FOC72_RS11400 ENOG4105BZ1 (ABC) transporter FOC72_RS11405 ENOG4105DIB Oligopeptide-binding protein FOC72_RS11415 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC72_RS11425 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FOC72_RS11470 ENOG4107BMA Transglycosylase associated protein