locus-tag	class	description
SSA_0002	COG0592	DNA-directed DNA polymerase activity
SSA_0005	COG0012	GTP binding
SSA_0006	COG0193	aminoacyl-tRNA hydrolase activity
SSA_0008	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SSA_0009	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SSA_0013	COG0037	tRNA processing
SSA_0014	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SSA_0015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSA_0019	COG3942	CHAP domain
SSA_0020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SSA_0022	COG4509	Sortase family
SSA_0023	COG0436	Aminotransferase
SSA_0025	COG1381	Involved in DNA repair and RecF pathway recombination
SSA_0026	COG0416	fatty acid biosynthetic process
SSA_0027	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSA_0028	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SSA_0030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SSA_0032	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SSA_0033	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SSA_0036	COG3942	CHAP domain
SSA_0037	COG0151	Belongs to the GarS family
SSA_0039	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SSA_0042	COG1794	racemase activity, acting on amino acids and derivatives
SSA_0046	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SSA_0047	COG2249	NAD(P)H dehydrogenase (quinone) activity
SSA_0049	COG2376	Dihydroxyacetone kinase
SSA_0050	COG1461	Dihydroxyacetone kinase
SSA_0051	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SSA_0052	COG2188	Transcriptional regulator
SSA_0054	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSA_0056	COG3716	PTS system mannose fructose sorbose family IID component
SSA_0060	COG2222	sugar isomerase
SSA_0061	COG3684	Belongs to the aldolase LacD family
SSA_0063	COG2255	four-way junction helicase activity
SSA_0065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SSA_0067	COG2755	lipolytic protein G-D-S-L family
SSA_0067	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SSA_0068	COG1012	belongs to the aldehyde dehydrogenase family
SSA_0068	COG1454	alcohol dehydrogenase
SSA_0070	COG3458	cephalosporin-C deacetylase activity
SSA_0071	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SSA_0072	COG3842	ATPase activity
SSA_0073	COG2731	YhcH YjgK YiaL family protein
SSA_0075	COG1175	transmembrane transport
SSA_0076	COG0395	ABC-type sugar transport system, permease component
SSA_0077	COG0673	inositol 2-dehydrogenase activity
SSA_0078	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSA_0085	COG1269	ATP hydrolysis coupled proton transport
SSA_0086	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SSA_0088	COG1527	subunit (C
SSA_0089	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SSA_0091	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SSA_0092	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SSA_0093	COG1394	ATPase activity, coupled to movement of substances
SSA_0100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSA_0100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSA_0101	COG1832	CoA-binding protein
SSA_0104	COG0343	queuine tRNA-ribosyltransferase activity
SSA_0106	COG0051	transcription antitermination factor activity, RNA binding
SSA_0107	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SSA_0108	COG0088	Forms part of the polypeptide exit tunnel
SSA_0109	COG0089	rRNA binding
SSA_0110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SSA_0111	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SSA_0112	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SSA_0113	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SSA_0114	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SSA_0115	COG0255	Belongs to the universal ribosomal protein uL29 family
SSA_0116	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SSA_0117	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SSA_0118	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SSA_0119	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SSA_0120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SSA_0122	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SSA_0123	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SSA_0124	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SSA_0125	COG1841	ribosomal large subunit assembly
SSA_0126	COG0200	Binds to the 23S rRNA
SSA_0127	COG0201	protein transport
SSA_0128	COG0563	adenylate kinase activity
SSA_0129	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SSA_0130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SSA_0131	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SSA_0132	COG0202	RNA polymerase activity
SSA_0133	COG0203	ribosomal protein L17
SSA_0135	COG1846	Transcriptional regulator
SSA_0136	COG1121	(ABC) transporter
SSA_0137	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSA_0138	COG3443	Belongs to the bacterial solute-binding protein 9 family
SSA_0138	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSA_0140	COG2217	Heavy metal translocating P-type atpase
SSA_0148	COG3842	ATPase activity
SSA_0156	COG0542	response to heat
SSA_0173	COG0500	methyltransferase
SSA_0176	COG0085	RNA polymerase activity
SSA_0177	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SSA_0178	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SSA_0181	COG1215	transferase activity, transferring glycosyl groups
SSA_0182	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SSA_0184	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSA_0185	COG1459	type II secretion system
SSA_0186	COG4537	Required for transformation and DNA binding
SSA_0192	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SSA_0197	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SSA_0198	COG0285	dihydrofolate synthase activity
SSA_0199	COG0302	gtp cyclohydrolase
SSA_0200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SSA_0200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SSA_0201	COG1131	(ABC) transporter
SSA_0208	COG4868	Belongs to the UPF0371 family
SSA_0209	COG1363	Peptidase, m42
SSA_0211	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSA_0212	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSA_0216	COG4585	Histidine kinase
SSA_0217	COG2197	response regulator
SSA_0221	COG3715	PTS system
SSA_0222	COG3716	PTS system mannose fructose sorbose family IID component
SSA_0225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SSA_0226	COG0459	protein refolding
SSA_0233	COG0628	permease
SSA_0236	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SSA_0242	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SSA_0243	COG0737	Belongs to the 5'-nucleotidase family
SSA_0251	COG1490	D-aminoacyl-tRNA deacylase activity
SSA_0254	COG1673	EVE domain
SSA_0255	COG1846	Transcriptional regulator
SSA_0263	COG3590	peptidase
SSA_0266	COG2801	Transposase and inactivated derivatives
SSA_0267	COG1940	carbohydrate kinase activity
SSA_0268	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSA_0269	COG1447	Phosphotransferase system cellobiose-specific component IIA
SSA_0270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSA_0272	COG4989	oxidoreductase activity
SSA_0276	COG1442	glycosyl transferase family 8
SSA_0276	COG1216	Glycosyl transferase, family 2
SSA_0277	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SSA_0278	COG1349	DNA-binding transcription factor activity
SSA_0279	COG2390	Transcriptional regulator
SSA_0282	COG1447	Phosphotransferase system cellobiose-specific component IIA
SSA_0283	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSA_0284	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSA_0285	COG1882	Formate acetyltransferase
SSA_0289	COG0495	leucyl-tRNA aminoacylation
SSA_0291	COG0300	oxidoreductase activity
SSA_0295	COG0583	DNA-binding transcription factor activity
SSA_0297	COG0281	malic enzyme
SSA_0298	COG0679	Auxin Efflux Carrier
SSA_0302	COG0126	phosphoglycerate kinase activity
SSA_0304	COG3942	CHAP domain
SSA_0306	COG0789	Transcriptional regulator
SSA_0307	COG0174	glutamine synthetase
SSA_0313	COG5503	Protein of unknown function (DUF1447)
SSA_0314	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSA_0316	COG1214	PFAM Peptidase M22, glycoprotease
SSA_0318	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SSA_0321	COG2226	methyltransferase
SSA_0322	COG0789	Transcriptional regulator
SSA_0323	COG2081	HI0933 family
SSA_0325	COG0584	glycerophosphoryl diester phosphodiesterase
SSA_0326	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SSA_0328	COG2936	dipeptidyl-peptidase activity
SSA_0329	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSA_0332	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SSA_0336	COG1304	FMN binding
SSA_0338	COG3425	synthase
SSA_0342	COG1882	Formate acetyltransferase
SSA_0343	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SSA_0349	COG1309	transcriptional regulator
SSA_0350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SSA_0351	COG0681	Belongs to the peptidase S26 family
SSA_0355	COG1193	negative regulation of DNA recombination
SSA_0357	COG3118	belongs to the thioredoxin family
SSA_0362	COG3118	belongs to the thioredoxin family
SSA_0363	COG1115	amino acid carrier protein
SSA_0364	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SSA_0365	COG0668	transmembrane transport
SSA_0367	COG5504	Zn-dependent protease
SSA_0371	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SSA_0373	COG0167	dihydroorotate dehydrogenase activity
SSA_0374	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSA_0374	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSA_0376	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SSA_0378	COG0402	S-adenosylhomocysteine deaminase activity
SSA_0379	COG2190	(PTS) system
SSA_0379	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSA_0379	COG1263	PTS System
SSA_0386	COG4175	Glycine betaine
SSA_0386	COG3448	diguanylate cyclase activity
SSA_0388	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SSA_0389	COG0561	phosphatase activity
SSA_0391	COG0028	Belongs to the TPP enzyme family
SSA_0393	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SSA_0395	COG2723	6-phospho-beta-galactosidase activity
SSA_0396	COG0596	Alpha beta hydrolase
SSA_0401	COG0745	RESPONSE REGULATOR receiver
SSA_0402	COG5002	protein histidine kinase activity
SSA_0407	COG1131	(ABC) transporter
SSA_0412	COG1131	(ABC) transporter
SSA_0415	COG0628	permease
SSA_0416	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SSA_0418	COG2207	Transcriptional regulator
SSA_0422	COG0588	phosphoglycerate mutase activity
SSA_0428	COG0010	Belongs to the arginase family
SSA_0429	COG2986	histidine ammonia-lyase
SSA_0430	COG0531	amino acid
SSA_0432	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SSA_0433	COG3404	Formiminotransferase-cyclodeaminase
SSA_0435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SSA_0436	COG1228	amidohydrolase
SSA_0437	COG0360	Binds together with S18 to 16S ribosomal RNA
SSA_0438	COG0629	single-stranded DNA binding
SSA_0440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SSA_0441	COG1309	transcriptional regulator
SSA_0442	COG1131	(ABC) transporter
SSA_0448	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SSA_0449	COG0006	proline dipeptidase activity
SSA_0450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SSA_0453	COG1523	belongs to the glycosyl hydrolase 13 family
SSA_0454	COG1609	Transcriptional regulator
SSA_0455	COG1621	beta-fructofuranosidase activity
SSA_0456	COG1263	PTS System
SSA_0456	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSA_0456	COG2190	(PTS) system
SSA_0457	COG1940	carbohydrate kinase activity
SSA_0458	COG0242	peptide deformylase activity
SSA_0460	COG1846	Transcriptional regulator
SSA_0462	COG1132	(ABC) transporter
SSA_0463	COG1797	cobyrinic acid a,c-diamide synthase activity
SSA_0464	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SSA_0467	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SSA_0477	COG0310	cobalt ion transport
SSA_0480	COG1122	ATPase activity
SSA_0481	COG1492	cobalamin metabolic process
SSA_0482	COG2096	Adenosyltransferase
SSA_0484	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SSA_0485	COG0181	hydroxymethylbilane synthase activity
SSA_0487	COG0113	porphobilinogen synthase activity
SSA_0488	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SSA_0489	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SSA_0490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SSA_0491	COG0406	alpha-ribazole phosphatase activity
SSA_0492	COG1902	pentaerythritol trinitrate reductase activity
SSA_0493	COG0747	negative chemotaxis
SSA_0494	COG0444	Belongs to the ABC transporter superfamily
SSA_0495	COG4608	Belongs to the ABC transporter superfamily
SSA_0498	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSA_0499	COG0747	negative chemotaxis
SSA_0500	COG0601	transmembrane transport
SSA_0502	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSA_0503	COG0444	Belongs to the ABC transporter superfamily
SSA_0506	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SSA_0513	COG2096	Adenosyltransferase
SSA_0519	COG4303	Ethanolamine ammonia lyase large subunit
SSA_0520	COG4302	ethanolamine ammonia-lyase activity
SSA_0522	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SSA_0523	COG1012	belongs to the aldehyde dehydrogenase family
SSA_0523	COG1454	alcohol dehydrogenase
SSA_0527	COG4869	propanediol catabolic process
SSA_0530	COG3192	ethanolamine utilization protein
SSA_0531	COG4766	ethanolamine catabolic process
SSA_0540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSA_0541	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SSA_0543	COG0653	protein targeting
SSA_0544	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SSA_0546	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SSA_0547	COG0736	holo-[acyl-carrier-protein] synthase activity
SSA_0548	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SSA_0549	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SSA_0551	COG0252	asparaginase activity
SSA_0552	COG0561	phosphatase activity
SSA_0561	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SSA_0564	COG0436	Aminotransferase
SSA_0566	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SSA_0567	COG1335	isochorismatase
SSA_0568	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SSA_0569	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSA_0570	COG0154	amidase activity
SSA_0571	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSA_0572	COG1063	alcohol dehydrogenase
SSA_0575	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SSA_0576	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SSA_0577	COG1534	Rna-binding protein
SSA_0578	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SSA_0579	COG1713	HD superfamily hydrolase involved in NAD metabolism
SSA_0580	COG1335	isochorismatase
SSA_0581	COG0799	negative regulation of ribosome biogenesis
SSA_0582	COG2226	methyltransferase
SSA_0583	COG1323	Belongs to the UPF0348 family
SSA_0586	COG0217	transcriptional regulatory protein
SSA_0587	COG1473	amidohydrolase
SSA_0588	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSA_0591	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
SSA_0592	COG4720	Psort location CytoplasmicMembrane, score
SSA_0593	COG1054	Belongs to the UPF0176 family
SSA_0602	COG1122	ATPase activity
SSA_0605	COG0357	Ribosomal RNA small subunit methyltransferase G
SSA_0606	COG0577	efflux transmembrane transporter activity
SSA_0606	COG1136	(ABC) transporter
SSA_0609	COG1309	transcriptional regulator
SSA_0610	COG1704	LemA family
SSA_0611	COG0501	Belongs to the peptidase M48B family
SSA_0612	COG1396	sequence-specific DNA binding
SSA_0613	COG0366	Alpha amylase catalytic
SSA_0613	COG5263	repeat protein
SSA_0615	COG1396	sequence-specific DNA binding
SSA_0617	COG2268	Band 7 protein
SSA_0621	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SSA_0622	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SSA_0624	COG0742	ribosomal rna small subunit methyltransferase
SSA_0625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SSA_0626	COG3480	Lon protease (S16) C-terminal proteolytic domain
SSA_0627	COG4470	Protein conserved in bacteria
SSA_0628	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SSA_0631	COG0133	tryptophan synthase activity
SSA_0632	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SSA_0633	COG0512	Glutamine amidotransferase of anthranilate synthase
SSA_0634	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SSA_0635	COG0134	indole-3-glycerol-phosphate synthase activity
SSA_0636	COG0135	phosphoribosylanthranilate isomerase activity
SSA_0638	COG0159	tryptophan synthase activity
SSA_0649	COG1187	pseudouridine synthase activity
SSA_0650	COG1217	gtp-binding protein TYPA
SSA_0652	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SSA_0653	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SSA_0654	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SSA_0656	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SSA_0657	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SSA_0658	COG1799	cell septum assembly
SSA_0660	COG3599	regulation of cell shape
SSA_0661	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SSA_0665	COG0494	nUDIX hydrolase
SSA_0665	COG0406	alpha-ribazole phosphatase activity
SSA_0667	COG2378	regulation of single-species biofilm formation
SSA_0669	COG0542	response to heat
SSA_0670	COG4703	Protein of unknown function (DUF1797)
SSA_0671	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SSA_0672	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSA_0673	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SSA_0674	COG1570	exodeoxyribonuclease VII activity
SSA_0675	COG1722	exodeoxyribonuclease VII activity
SSA_0677	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SSA_0678	COG1438	arginine binding
SSA_0679	COG0497	DNA recombination
SSA_0680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SSA_0682	COG1307	EDD domain protein, DegV family
SSA_0686	COG0735	belongs to the Fur family
SSA_0688	COG0588	phosphoglycerate mutase activity
SSA_0689	COG0768	penicillin binding
SSA_0690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SSA_0691	COG1181	Belongs to the D-alanine--D-alanine ligase family
SSA_0692	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SSA_0694	COG1051	belongs to the nudix hydrolase family
SSA_0698	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SSA_0702	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SSA_0703	COG0372	Belongs to the citrate synthase family
SSA_0704	COG0538	isocitrate dehydrogenase activity
SSA_0706	COG0513	Belongs to the DEAD box helicase family
SSA_0707	COG1349	DNA-binding transcription factor activity
SSA_0708	COG1755	Isoprenylcysteine carboxyl methyltransferase
SSA_0709	COG2827	Endonuclease containing a URI domain
SSA_0711	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SSA_0712	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SSA_0713	COG0204	Acyl-transferase
SSA_0715	COG1596	polysaccharide export
SSA_0715	COG1555	photosystem II stabilization
SSA_0716	COG2333	competence protein COMEC
SSA_0716	COG0658	competence protein
SSA_0720	COG1466	dna polymerase III delta subunit
SSA_0721	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SSA_0730	COG0640	Transcriptional regulator
SSA_0733	COG4377	Putative membrane peptidase family (DUF2324)
SSA_0734	COG0640	Transcriptional regulator
SSA_0737	COG2235	arginine
SSA_0739	COG0549	Belongs to the carbamate kinase family
SSA_0740	COG1288	antiporter activity
SSA_0741	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSA_0743	COG1438	arginine binding
SSA_0744	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SSA_0746	COG0363	glucosamine-6-phosphate deaminase activity
SSA_0752	COG4122	O-methyltransferase activity
SSA_0753	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SSA_0756	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSA_0757	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SSA_0758	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SSA_0759	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SSA_0760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SSA_0761	COG1476	TRANSCRIPTIONal
SSA_0767	COG1597	lipid kinase activity
SSA_0770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSA_0771	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SSA_0772	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSA_0774	COG1012	belongs to the aldehyde dehydrogenase family
SSA_0775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SSA_0776	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SSA_0777	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SSA_0778	COG0297	glycogen (starch) synthase activity
SSA_0779	COG0058	SHG alpha-glucan phosphorylase activity
SSA_0781	COG1482	cell wall glycoprotein biosynthetic process
SSA_0783	COG0356	it plays a direct role in the translocation of protons across the membrane
SSA_0784	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SSA_0785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SSA_0786	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SSA_0787	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SSA_0788	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SSA_0789	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SSA_0791	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSA_0796	COG0488	(ABC) transporter
SSA_0800	COG3442	glutamine amidotransferase
SSA_0801	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SSA_0802	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SSA_0804	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSA_0807	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SSA_0809	COG0251	oxidation-reduction process
SSA_0810	COG1660	Displays ATPase and GTPase activities
SSA_0811	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SSA_0812	COG1481	regulation of sporulation
SSA_0813	COG0492	ferredoxin-NADP+ reductase activity
SSA_0814	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSA_0815	COG3759	membrane
SSA_0820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SSA_0822	COG1970	mechanosensitive ion channel activity
SSA_0824	COG0358	DNA primase activity
SSA_0825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SSA_0826	COG2151	metal-sulfur cluster biosynthetic enzyme
SSA_0832	COG0201	protein transport
SSA_0836	COG0653	protein targeting
SSA_0843	COG1346	cytolysis
SSA_0845	COG1131	(ABC) transporter
SSA_0847	COG0205	6-phosphofructokinase activity
SSA_0848	COG0469	pyruvate kinase activity
SSA_0851	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SSA_0854	COG1051	belongs to the nudix hydrolase family
SSA_0855	COG2873	o-acetylhomoserine
SSA_0856	COG0463	Glycosyl transferase, family 2
SSA_0858	COG1091	dTDP-4-dehydrorhamnose reductase activity
SSA_0862	COG2348	transferase activity, transferring amino-acyl groups
SSA_0864	COG1078	dGTPase activity
SSA_0869	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SSA_0870	COG2884	Cell division ATP-binding protein ftsE
SSA_0871	COG2177	Part of the ABC transporter FtsEX involved in
SSA_0873	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SSA_0873	COG1199	ATP-dependent helicase activity
SSA_0875	COG0772	Belongs to the SEDS family
SSA_0878	COG0187	DNA topoisomerase II activity
SSA_0879	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SSA_0882	COG0560	Phosphoserine phosphatase
SSA_0886	COG0148	phosphopyruvate hydratase activity
SSA_0888	COG2239	Acts as a magnesium transporter
SSA_0891	COG2706	6-phosphogluconolactonase activity
SSA_0894	COG1136	(ABC) transporter
SSA_0895	COG0577	efflux transmembrane transporter activity
SSA_0897	COG5002	protein histidine kinase activity
SSA_0897	COG3850	Histidine kinase
SSA_0899	COG0628	permease
SSA_0901	COG3527	Alpha-acetolactate decarboxylase
SSA_0907	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SSA_0910	COG1131	(ABC) transporter
SSA_0914	COG0072	phenylalanine-tRNA ligase activity
SSA_0914	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSA_0921	COG1063	alcohol dehydrogenase
SSA_0924	COG0577	efflux transmembrane transporter activity
SSA_0925	COG1136	(ABC) transporter
SSA_0928	COG1132	(ABC) transporter
SSA_0928	COG2375	cellular response to nickel ion
SSA_0929	COG1132	(ABC) transporter
SSA_0935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SSA_0936	COG0196	riboflavin kinase activity
SSA_0937	COG1393	Belongs to the ArsC family
SSA_0938	COG4476	Belongs to the UPF0223 family
SSA_0939	COG0483	inositol monophosphate 1-phosphatase activity
SSA_0940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SSA_0940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SSA_0941	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SSA_0942	COG0573	inorganic phosphate transmembrane transporter activity
SSA_0943	COG0581	inorganic phosphate transmembrane transporter activity
SSA_0944	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SSA_0945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SSA_0946	COG0704	Plays a role in the regulation of phosphate uptake
SSA_0959	COG0745	RESPONSE REGULATOR receiver
SSA_0960	COG5002	protein histidine kinase activity
SSA_0963	COG0726	polysaccharide deacetylase
SSA_0965	COG0673	inositol 2-dehydrogenase activity
SSA_0966	COG0572	uridine kinase
SSA_0980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SSA_0981	COG0066	3-isopropylmalate dehydratase activity
SSA_0984	COG1846	Transcriptional regulator
SSA_0987	COG1174	glycine betaine transport
SSA_0996	COG1956	GAF domain-containing protein
SSA_0997	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SSA_0999	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SSA_0999	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SSA_1000	COG1609	Transcriptional regulator
SSA_1001	COG2207	Transcriptional regulator
SSA_1002	COG3345	alpha-galactosidase
SSA_1003	COG1653	transport
SSA_1004	COG1175	transmembrane transport
SSA_1005	COG0395	ABC-type sugar transport system, permease component
SSA_1006	COG0366	Alpha amylase catalytic
SSA_1007	COG3842	ATPase activity
SSA_1008	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SSA_1009	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SSA_1010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SSA_1013	COG1183	phosphatidylcholine synthase activity
SSA_1014	COG0688	phosphatidylethanolamine metabolic process
SSA_1016	COG0574	Belongs to the PEP-utilizing enzyme family
SSA_1016	COG3848	Pyruvate phosphate dikinase
SSA_1018	COG3583	domain protein
SSA_1018	COG3583	domain protein
SSA_1021	COG1363	Peptidase, m42
SSA_1026	COG1131	(ABC) transporter
SSA_1032	COG0268	Binds directly to 16S ribosomal RNA
SSA_1033	COG1072	(Pantothenic acid kinase))
SSA_1034	COG2813	Specifically methylates the guanine in position
SSA_1036	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SSA_1037	COG0295	cytidine deaminase activity
SSA_1038	COG1744	ABC transporter substrate-binding protein PnrA-like
SSA_1039	COG3845	ABC transporter
SSA_1040	COG4603	Belongs to the binding-protein-dependent transport system permease family
SSA_1041	COG1079	Belongs to the binding-protein-dependent transport system permease family
SSA_1044	COG0083	homoserine kinase activity
SSA_1047	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SSA_1048	COG3842	ATPase activity
SSA_1049	COG1175	transmembrane transport
SSA_1050	COG1177	transmembrane transport
SSA_1053	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SSA_1053	COG0574	Belongs to the PEP-utilizing enzyme family
SSA_1054	COG0517	IMP dehydrogenase activity
SSA_1055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SSA_1056	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SSA_1057	COG1104	cysteine desulfurase activity
SSA_1058	COG0301	tRNA thio-modification
SSA_1061	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SSA_1062	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SSA_1065	COG1472	Belongs to the glycosyl hydrolase 3 family
SSA_1066	COG4166	transmembrane transport
SSA_1067	COG0456	acetyltransferase
SSA_1068	COG0583	DNA-binding transcription factor activity
SSA_1070	COG0564	pseudouridine synthase activity
SSA_1072	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SSA_1073	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SSA_1074	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SSA_1075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SSA_1077	COG0647	UMP catabolic process
SSA_1079	COG1266	CAAX protease self-immunity
SSA_1080	COG1349	DNA-binding transcription factor activity
SSA_1081	COG1105	Belongs to the carbohydrate kinase PfkB family
SSA_1082	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSA_1082	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSA_1082	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSA_1084	COG1307	EDD domain protein, DegV family
SSA_1085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SSA_1086	COG0617	tRNA 3'-terminal CCA addition
SSA_1087	COG0488	(ABC) transporter
SSA_1090	COG1940	carbohydrate kinase activity
SSA_1091	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SSA_1092	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SSA_1093	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SSA_1094	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SSA_1095	COG1388	LysM domain
SSA_1095	COG1705	Flagellar rod assembly protein muramidase FlgJ
SSA_1096	COG2040	homocysteine
SSA_1098	COG2116	formate transmembrane transporter activity
SSA_1101	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SSA_1104	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SSA_1105	COG0222	ribosome binding
SSA_1111	COG1114	Component of the transport system for branched-chain amino acids
SSA_1113	COG0745	RESPONSE REGULATOR receiver
SSA_1114	COG5002	protein histidine kinase activity
SSA_1115	COG0785	Cytochrome C biogenesis protein
SSA_1118	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSA_1118	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSA_1119	COG4753	response regulator
SSA_1119	COG2207	Transcriptional regulator
SSA_1120	COG2972	Histidine kinase
SSA_1121	COG0785	Cytochrome C biogenesis protein
SSA_1122	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSA_1124	COG0431	NADPH-dependent FMN reductase
SSA_1124	COG1053	succinate dehydrogenase
SSA_1124	COG3976	FMN-binding domain protein
SSA_1128	COG0038	chloride channel
SSA_1129	COG2822	iron ion transport
SSA_1130	COG2837	iron assimilation
SSA_1131	COG0672	)-iron permease
SSA_1132	COG0805	protein transport
SSA_1133	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SSA_1134	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSA_1135	COG0534	Mate efflux family protein
SSA_1136	COG0542	response to heat
SSA_1137	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSA_1138	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SSA_1139	COG0022	dehydrogenase e1 component
SSA_1140	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSA_1143	COG0534	Mate efflux family protein
SSA_1146	COG1447	Phosphotransferase system cellobiose-specific component IIA
SSA_1147	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSA_1148	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSA_1149	COG2723	6-phospho-beta-galactosidase activity
SSA_1150	COG1942	4-Oxalocrotonate Tautomerase
SSA_1151	COG1435	thymidine kinase activity
SSA_1152	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SSA_1153	COG2890	protein-(glutamine-N5) methyltransferase activity
SSA_1154	COG0009	L-threonylcarbamoyladenylate synthase
SSA_1155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SSA_1157	COG0741	lytic transglycosylase activity
SSA_1165	COG2188	Transcriptional regulator
SSA_1167	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SSA_1171	COG4974	Belongs to the 'phage' integrase family
SSA_1173	COG0095	Lipoate-protein ligase
SSA_1174	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSA_1175	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSA_1176	COG0022	dehydrogenase e1 component
SSA_1178	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SSA_1182	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SSA_1183	COG0135	phosphoribosylanthranilate isomerase activity
SSA_1184	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SSA_1185	COG0758	DNA mediated transformation
SSA_1186	COG0110	maltose O-acetyltransferase activity
SSA_1187	COG3711	transcriptional antiterminator
SSA_1188	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SSA_1189	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SSA_1193	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSA_1194	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SSA_1199	COG1247	-acetyltransferase
SSA_1200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SSA_1202	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SSA_1203	COG4684	Psort location CytoplasmicMembrane, score
SSA_1204	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSA_1206	COG1194	a g-specific adenine glycosylase
SSA_1207	COG0280	phosphate acetyltransferase
SSA_1209	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SSA_1210	COG2357	RelA SpoT domain protein
SSA_1212	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SSA_1213	COG1104	cysteine desulfurase activity
SSA_1217	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SSA_1218	COG2003	Belongs to the UPF0758 family
SSA_1219	COG3764	Sortase (surface protein transpeptidase)
SSA_1220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SSA_1221	COG0039	L-malate dehydrogenase activity
SSA_1223	COG0539	negative regulation of cytoplasmic translation
SSA_1225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SSA_1226	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SSA_1232	COG0187	DNA topoisomerase II activity
SSA_1233	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SSA_1234	COG0737	Belongs to the 5'-nucleotidase family
SSA_1236	COG1051	belongs to the nudix hydrolase family
SSA_1237	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SSA_1240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SSA_1241	COG0284	orotidine-5'-phosphate decarboxylase activity
SSA_1242	COG0167	dihydroorotate dehydrogenase activity
SSA_1243	COG0543	2 iron, 2 sulfur cluster binding
SSA_1248	COG1567	CRISPR-associated RAMP protein, Csm4 family
SSA_1249	COG1337	RAMP superfamily
SSA_1253	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SSA_1258	COG0813	purine-nucleoside phosphorylase activity
SSA_1260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SSA_1261	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SSA_1262	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SSA_1265	COG0335	large ribosomal subunit rRNA binding
SSA_1266	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SSA_1267	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SSA_1270	COG0716	FMN binding
SSA_1271	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SSA_1272	COG0254	rRNA binding
SSA_1277	COG1876	peptidase activity
SSA_1278	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSA_1278	COG0425	Belongs to the sulfur carrier protein TusA family
SSA_1279	COG1063	alcohol dehydrogenase
SSA_1281	COG1573	uracil-dna glycosylase
SSA_1282	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSA_1297	COG0322	excinuclease ABC activity
SSA_1299	COG1175	transmembrane transport
SSA_1300	COG3833	ABC-type maltose transport systems, permease component
SSA_1302	COG0336	Belongs to the RNA methyltransferase TrmD family
SSA_1303	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SSA_1306	COG0569	domain protein
SSA_1307	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SSA_1309	COG1837	Belongs to the UPF0109 family
SSA_1310	COG0228	four-way junction DNA binding
SSA_1311	COG1011	Hydrolase
SSA_1313	COG2207	Transcriptional regulator
SSA_1313	COG3708	Transcriptional regulator
SSA_1318	COG0481	GTPase activity
SSA_1319	COG0561	phosphatase activity
SSA_1325	COG4221	oxidoreductase activity
SSA_1326	COG2195	Cleaves the N-terminal amino acid of tripeptides
SSA_1340	COG3443	Belongs to the bacterial solute-binding protein 9 family
SSA_1340	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSA_1341	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SSA_1342	COG0505	Belongs to the CarA family
SSA_1343	COG0540	Belongs to the ATCase OTCase family
SSA_1345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SSA_1347	COG2824	Alkylphosphonate utilization operon protein PhnA
SSA_1349	COG1827	regulation of RNA biosynthetic process
SSA_1350	COG1051	belongs to the nudix hydrolase family
SSA_1354	COG0456	acetyltransferase
SSA_1356	COG0556	nucleotide-excision repair
SSA_1359	COG4215	(ABC) transporter
SSA_1362	COG2801	Transposase and inactivated derivatives
SSA_1373	COG0488	(ABC) transporter
SSA_1374	COG1132	(ABC) transporter
SSA_1375	COG1132	(ABC) transporter
SSA_1377	COG0017	Asparaginyl-tRNA synthetase
SSA_1383	COG0436	Aminotransferase
SSA_1385	COG1846	Transcriptional regulator
SSA_1386	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SSA_1395	COG3022	response to hydroperoxide
SSA_1398	COG1272	protein, Hemolysin III
SSA_1401	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSA_1402	COG1132	(ABC) transporter
SSA_1403	COG1132	(ABC) transporter
SSA_1404	COG2315	Protein conserved in bacteria
SSA_1405	COG3142	Participates in the control of copper homeostasis
SSA_1406	COG1247	-acetyltransferase
SSA_1409	COG1088	dTDP-glucose 4,6-dehydratase activity
SSA_1411	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SSA_1414	COG1051	belongs to the nudix hydrolase family
SSA_1415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SSA_1416	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SSA_1417	COG2384	SAM-dependent methyltransferase
SSA_1418	COG0625	glutathione transferase activity
SSA_1420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SSA_1421	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSA_1423	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SSA_1423	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SSA_1429	COG0300	oxidoreductase activity
SSA_1430	COG1234	tRNA 3'-trailer cleavage
SSA_1432	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SSA_1433	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SSA_1436	COG2378	regulation of single-species biofilm formation
SSA_1440	COG0140	phosphoribosyl-ATP diphosphatase activity
SSA_1441	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SSA_1442	COG0107	imidazoleglycerol-phosphate synthase activity
SSA_1443	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SSA_1444	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SSA_1445	COG0131	Imidazoleglycerol-phosphate dehydratase
SSA_1446	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SSA_1447	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SSA_1448	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SSA_1449	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SSA_1451	COG1074	ATP-dependent DNA helicase activity
SSA_1452	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SSA_1457	COG0366	Alpha amylase catalytic
SSA_1458	COG0510	thiamine kinase activity
SSA_1459	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSA_1462	COG0077	Prephenate dehydratase
SSA_1463	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SSA_1464	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SSA_1465	COG3679	Belongs to the UPF0342 family
SSA_1466	COG0287	Prephenate dehydrogenase
SSA_1467	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SSA_1468	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SSA_1469	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SSA_1470	COG0710	3-dehydroquinate dehydratase activity
SSA_1471	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SSA_1476	COG1368	sulfuric ester hydrolase activity
SSA_1482	COG1523	belongs to the glycosyl hydrolase 13 family
SSA_1483	COG1597	lipid kinase activity
SSA_1484	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SSA_1485	COG4708	membrane
SSA_1486	COG2246	polysaccharide biosynthetic process
SSA_1488	COG1846	Transcriptional regulator
SSA_1491	COG0024	Methionine aminopeptidase
SSA_1492	COG4109	DRTGG domain
SSA_1494	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSA_1495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SSA_1497	COG2131	deaminase
SSA_1498	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SSA_1499	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SSA_1501	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SSA_1505	COG1368	sulfuric ester hydrolase activity
SSA_1509	COG1215	transferase activity, transferring glycosyl groups
SSA_1513	COG1216	Glycosyl transferase, family 2
SSA_1513	COG1442	glycosyl transferase family 8
SSA_1516	COG1216	Glycosyl transferase, family 2
SSA_1517	COG1442	glycosyl transferase family 8
SSA_1517	COG1216	Glycosyl transferase, family 2
SSA_1518	COG1442	glycosyl transferase family 8
SSA_1518	COG1216	Glycosyl transferase, family 2
SSA_1520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SSA_1521	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SSA_1522	COG0772	Belongs to the SEDS family
SSA_1523	COG0386	Belongs to the glutathione peroxidase family
SSA_1527	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SSA_1529	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SSA_1530	COG0577	efflux transmembrane transporter activity
SSA_1531	COG1136	(ABC) transporter
SSA_1532	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SSA_1533	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSA_1536	COG1268	BioY protein
SSA_1537	COG4443	Transcriptional Coactivator p15 (PC4)
SSA_1541	COG0826	peptidase U32
SSA_1546	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SSA_1547	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SSA_1548	COG1051	belongs to the nudix hydrolase family
SSA_1550	COG3091	SprT-like family
SSA_1551	COG2183	response to ionizing radiation
SSA_1553	COG0701	Predicted permease
SSA_1554	COG3689	TIGRFAM TIGR03943 family protein
SSA_1555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SSA_1557	COG0552	protein localization to endoplasmic reticulum
SSA_1558	COG0561	phosphatase activity
SSA_1559	COG0561	phosphatase activity
SSA_1560	COG1196	nuclear chromosome segregation
SSA_1561	COG0571	ribonuclease III activity
SSA_1562	COG2832	Protein of unknown function (DUF454)
SSA_1563	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SSA_1564	COG5002	protein histidine kinase activity
SSA_1565	COG0745	RESPONSE REGULATOR receiver
SSA_1566	COG1126	abc transporter atp-binding protein
SSA_1567	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSA_1568	COG0765	amino acid transport
SSA_1569	COG0765	amino acid transport
SSA_1571	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SSA_1574	COG0438	transferase activity, transferring glycosyl groups
SSA_1576	COG1609	Transcriptional regulator
SSA_1577	COG0006	proline dipeptidase activity
SSA_1579	COG1120	ATPase activity
SSA_1583	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SSA_1584	COG2514	catechol 2,3-dioxygenase activity
SSA_1585	COG2910	NAD(P)H-binding
SSA_1586	COG1959	2 iron, 2 sulfur cluster binding
SSA_1590	COG1309	transcriptional regulator
SSA_1594	COG3590	peptidase
SSA_1595	COG0500	methyltransferase
SSA_1595	COG3615	Tellurite resistance protein tehB
SSA_1601	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SSA_1602	COG0557	exoribonuclease II activity
SSA_1605	COG2814	Major facilitator Superfamily
SSA_1606	COG0237	dephospho-CoA kinase activity
SSA_1607	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SSA_1610	COG3177	Filamentation induced by cAMP protein fic
SSA_1611	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SSA_1612	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SSA_1613	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SSA_1614	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSA_1615	COG0686	Belongs to the AlaDH PNT family
SSA_1616	COG1702	phosphate starvation-inducible protein PhoH
SSA_1617	COG4479	Belongs to the UPF0346 family
SSA_1618	COG2996	Protein conserved in bacteria
SSA_1619	COG0233	cytoplasmic translational termination
SSA_1620	COG0528	UMP kinase activity
SSA_1621	COG0531	amino acid
SSA_1622	COG0081	regulation of translation
SSA_1623	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SSA_1625	COG0346	lactoylglutathione lyase activity
SSA_1626	COG1674	ftsk spoiiie
SSA_1626	COG0697	spore germination
SSA_1627	COG1983	PspC domain protein
SSA_1628	COG0494	nUDIX hydrolase
SSA_1636	COG0488	(ABC) transporter
SSA_1639	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SSA_1642	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SSA_1650	COG1028	Short-chain dehydrogenase reductase Sdr
SSA_1658	COG0531	amino acid
SSA_1659	COG0577	efflux transmembrane transporter activity
SSA_1660	COG1136	(ABC) transporter
SSA_1662	COG1902	pentaerythritol trinitrate reductase activity
SSA_1664	COG2226	methyltransferase
SSA_1670	COG1309	transcriptional regulator
SSA_1676	COG3279	Response regulator of the LytR AlgR family
SSA_1680	COG0577	efflux transmembrane transporter activity
SSA_1681	COG1136	(ABC) transporter
SSA_1684	COG5002	protein histidine kinase activity
SSA_1685	COG0745	RESPONSE REGULATOR receiver
SSA_1687	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SSA_1691	COG3655	Transcriptional regulator
SSA_1692	COG2723	6-phospho-beta-galactosidase activity
SSA_1695	COG3711	transcriptional antiterminator
SSA_1696	COG3684	Belongs to the aldolase LacD family
SSA_1697	COG1105	Belongs to the carbohydrate kinase PfkB family
SSA_1698	COG0698	ribose 5-phosphate isomerase
SSA_1699	COG0698	ribose 5-phosphate isomerase
SSA_1701	COG1349	DNA-binding transcription factor activity
SSA_1703	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSA_1703	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSA_1706	COG0708	Exodeoxyribonuclease III
SSA_1711	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SSA_1712	COG1393	Belongs to the ArsC family
SSA_1713	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SSA_1715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SSA_1720	COG4467	Involved in initiation control of chromosome replication
SSA_1721	COG0470	DNA polymerase III
SSA_1722	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSA_1723	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSA_1724	COG0517	IMP dehydrogenase activity
SSA_1729	COG0683	leucine binding
SSA_1730	COG4471	UPF0298 protein
SSA_1731	COG0740	serine-type endopeptidase activity
SSA_1732	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SSA_1734	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SSA_1736	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SSA_1737	COG0626	cystathionine gamma-synthase activity
SSA_1738	COG2244	polysaccharide biosynthetic process
SSA_1739	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SSA_1741	COG1120	ATPase activity
SSA_1742	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SSA_1743	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSA_1744	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSA_1748	COG1227	inorganic diphosphatase activity
SSA_1749	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SSA_1751	COG0366	Alpha amylase catalytic
SSA_1752	COG1263	PTS System
SSA_1752	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSA_1753	COG2188	Transcriptional regulator
SSA_1761	COG1253	flavin adenine dinucleotide binding
SSA_1762	COG0628	permease
SSA_1763	COG1119	ATPase activity
SSA_1765	COG2226	methyltransferase
SSA_1768	COG1309	transcriptional regulator
SSA_1769	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SSA_1770	COG1242	4 iron, 4 sulfur cluster binding
SSA_1772	COG0671	phosphoesterase, PA-phosphatase related
SSA_1773	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SSA_1775	COG0569	domain protein
SSA_1776	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SSA_1777	COG1187	pseudouridine synthase activity
SSA_1778	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SSA_1779	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SSA_1780	COG4974	Belongs to the 'phage' integrase family
SSA_1783	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SSA_1784	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SSA_1790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSA_1791	COG1254	Belongs to the acylphosphatase family
SSA_1793	COG5002	protein histidine kinase activity
SSA_1794	COG0745	RESPONSE REGULATOR receiver
SSA_1795	COG2357	RelA SpoT domain protein
SSA_1796	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SSA_1797	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SSA_1800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SSA_1802	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SSA_1803	COG1160	GTP binding
SSA_1805	COG1484	DNA-dependent DNA replication
SSA_1807	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SSA_1809	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSA_1809	COG2190	(PTS) system
SSA_1809	COG1263	PTS System
SSA_1810	COG0745	RESPONSE REGULATOR receiver
SSA_1811	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SSA_1821	COG0519	Catalyzes the synthesis of GMP from XMP
SSA_1826	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SSA_1827	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SSA_1828	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSA_1829	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSA_1831	COG2137	regulation of response to DNA damage stimulus
SSA_1832	COG3557	Belongs to the UPF0374 family
SSA_1835	COG1040	competence protein
SSA_1836	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SSA_1837	COG1739	Uncharacterized protein family UPF0029
SSA_1840	COG1185	polyribonucleotide nucleotidyltransferase activity
SSA_1843	COG4585	Histidine kinase
SSA_1845	COG0515	serine threonine protein kinase
SSA_1845	COG2815	serine threonine protein kinase
SSA_1846	COG0631	protein serine/threonine phosphatase activity
SSA_1847	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SSA_1847	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SSA_1848	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SSA_1849	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SSA_1850	COG1758	RNA polymerase activity
SSA_1851	COG0194	GDP metabolic process
SSA_1852	COG1418	mRNA catabolic process
SSA_1853	COG1854	S-ribosylhomocysteine lyase activity
SSA_1855	COG0116	Belongs to the methyltransferase superfamily
SSA_1857	COG3599	regulation of cell shape
SSA_1858	COG4474	Belongs to the UPF0398 family
SSA_1859	COG3331	DNA recombination
SSA_1860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSA_1861	COG3579	cysteine-type endopeptidase activity
SSA_1862	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSA_1863	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SSA_1864	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SSA_1865	COG0492	ferredoxin-NADP+ reductase activity
SSA_1867	COG1126	abc transporter atp-binding protein
SSA_1868	COG0765	amino acid transport
SSA_1869	COG0513	Belongs to the DEAD box helicase family
SSA_1870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSA_1871	COG0768	penicillin binding
SSA_1873	COG0275	rRNA processing
SSA_1878	COG4224	UPF0291 protein
SSA_1879	COG0751	glycine-tRNA ligase activity
SSA_1880	COG0752	glycyl-tRNA synthetase alpha subunit
SSA_1891	COG0656	L-ascorbic acid biosynthetic process
SSA_1895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SSA_1896	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SSA_1899	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SSA_1900	COG0195	Participates in both transcription termination and antitermination
SSA_1901	COG0779	Required for maturation of 30S ribosomal subunits
SSA_1902	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SSA_1905	COG1131	(ABC) transporter
SSA_1906	COG0537	adenosine 5'-monophosphoramidase activity
SSA_1909	COG1316	TRANSCRIPTIONal
SSA_1910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSA_1911	COG0802	atpase or kinase
SSA_1913	COG2252	PERMEase
SSA_1916	COG0561	phosphatase activity
SSA_1917	COG1064	alcohol dehydrogenase
SSA_1919	COG3715	PTS system
SSA_1920	COG3716	PTS system mannose fructose sorbose family IID component
SSA_1924	COG1309	transcriptional regulator
SSA_1925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SSA_1930	COG0825	malonyl-CoA metabolic process
SSA_1931	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SSA_1932	COG0439	Biotin carboxylase
SSA_1933	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SSA_1935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SSA_1936	COG1028	Short-chain dehydrogenase reductase Sdr
SSA_1937	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SSA_1940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSA_1941	COG1846	Transcriptional regulator
SSA_1942	COG1024	Enoyl-CoA hydratase
SSA_1943	COG0527	aspartate kinase activity
SSA_1944	COG4608	Belongs to the ABC transporter superfamily
SSA_1945	COG0444	Belongs to the ABC transporter superfamily
SSA_1946	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSA_1947	COG0601	transmembrane transport
SSA_1948	COG4166	transmembrane transport
SSA_1949	COG4166	transmembrane transport
SSA_1950	COG4166	transmembrane transport
SSA_1951	COG1686	Belongs to the peptidase S11 family
SSA_1952	COG0719	Fe-S assembly protein
SSA_1954	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SSA_1955	COG0719	Fe-S assembly protein
SSA_1957	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSA_1958	COG4862	establishment of competence for transformation
SSA_1959	COG1968	undecaprenyl-diphosphatase activity
SSA_1961	COG0765	amino acid transport
SSA_1962	COG1126	abc transporter atp-binding protein
SSA_1967	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SSA_1968	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSA_1969	COG0440	acetolactate synthase activity
SSA_1970	COG0028	Belongs to the TPP enzyme family
SSA_1972	COG2197	response regulator
SSA_1973	COG4585	Histidine kinase
SSA_1975	COG1131	(ABC) transporter
SSA_1980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SSA_1989	COG4555	ABC transporter
SSA_1990	COG3443	Belongs to the bacterial solute-binding protein 9 family
SSA_1990	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSA_1992	COG0191	fructose-bisphosphate aldolase activity
SSA_1994	COG0504	CTP synthase activity
SSA_1996	COG3343	RNA polymerase activity
SSA_1998	COG0544	peptidyl-prolyl cis-trans isomerase activity
SSA_1999	COG4475	Protein of unknown function (DUF436)
SSA_2000	COG4720	Psort location CytoplasmicMembrane, score
SSA_2001	COG0351	phosphomethylpyrimidine kinase
SSA_2002	COG0101	tRNA pseudouridine synthase activity
SSA_2004	COG3064	Membrane
SSA_2005	COG0484	heat shock protein binding
SSA_2007	COG0443	Heat shock 70 kDa protein
SSA_2008	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SSA_2009	COG1420	regulation of RNA biosynthetic process
SSA_2014	COG1876	peptidase activity
SSA_2015	COG0588	phosphoglycerate mutase activity
SSA_2018	COG2848	UPF0210 protein
SSA_2019	COG3830	Belongs to the UPF0237 family
SSA_2021	COG3804	dihydrodipicolinate reductase
SSA_2022	COG4978	Transcriptional regulator
SSA_2022	COG0789	Transcriptional regulator
SSA_2023	COG1621	beta-fructofuranosidase activity
SSA_2023	COG5492	domain, Protein
SSA_2023	COG3583	domain protein
SSA_2025	COG1162	GTPase activity
SSA_2027	COG2217	Heavy metal translocating P-type atpase
SSA_2029	COG3328	transposase activity
SSA_2030	COG1597	lipid kinase activity
SSA_2033	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SSA_2034	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SSA_2036	COG3688	RNA-binding protein containing a PIN domain
SSA_2037	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSA_2039	COG0531	amino acid
SSA_2040	COG3842	ATPase activity
SSA_2042	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SSA_2044	COG0215	cysteine-tRNA ligase activity
SSA_2048	COG1045	serine acetyltransferase
SSA_2049	COG1185	polyribonucleotide nucleotidyltransferase activity
SSA_2050	COG2814	Major facilitator Superfamily
SSA_2051	COG1164	Oligoendopeptidase f
SSA_2052	COG3118	belongs to the thioredoxin family
SSA_2058	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SSA_2059	COG1187	pseudouridine synthase activity
SSA_2061	COG0242	peptide deformylase activity
SSA_2063	COG2309	aminopeptidase activity
SSA_2066	COG2176	DNA-directed DNA polymerase activity
SSA_2069	COG0442	prolyl-tRNA aminoacylation
SSA_2070	COG0750	zinc metalloprotease
SSA_2072	COG4589	Belongs to the CDS family
SSA_2073	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SSA_2075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SSA_2079	COG0110	maltose O-acetyltransferase activity
SSA_2082	COG1070	Carbohydrate kinase
SSA_2084	COG3775	system Galactitol-specific IIC component
SSA_2087	COG1609	Transcriptional regulator
SSA_2089	COG3623	hexulose-6-phosphate isomerase
SSA_2091	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSA_2093	COG3037	sugar-specific permease SgaT UlaA
SSA_2097	COG1126	abc transporter atp-binding protein
SSA_2098	COG0765	amino acid transport
SSA_2099	COG0765	amino acid transport
SSA_2101	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSA_2107	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SSA_2109	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SSA_2110	COG0049	tRNA binding
SSA_2111	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SSA_2114	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSA_2116	COG3481	metal-dependent phosphohydrolase, HD sub domain
SSA_2118	COG1564	THIamine pyrophosphokinase
SSA_2120	COG1162	GTPase activity
SSA_2123	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SSA_2126	COG0084	hydrolase, TatD family'
SSA_2131	COG3655	Transcriptional regulator
SSA_2133	COG0519	Catalyzes the synthesis of GMP from XMP
SSA_2136	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SSA_2138	COG1847	R3H domain protein
SSA_2140	COG0594	ribonuclease P activity
SSA_2141	COG0165	Argininosuccinate lyase
SSA_2142	COG0137	argininosuccinate synthase activity
SSA_2144	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSA_2147	COG3237	CsbD-like
SSA_2150	COG2261	transglycosylase associated protein
SSA_2151	COG3711	transcriptional antiterminator
SSA_2152	COG1122	ATPase activity
SSA_2157	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SSA_2160	COG0756	dUTP diphosphatase activity
SSA_2164	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SSA_2165	COG4166	transmembrane transport
SSA_2166	COG1132	(ABC) transporter
SSA_2167	COG1132	(ABC) transporter
SSA_2168	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SSA_2169	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SSA_2171	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SSA_2173	COG1473	amidohydrolase
SSA_2174	COG2171	N-acyltransferase activity
SSA_2183	COG0166	Belongs to the GPI family
SSA_2185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SSA_2186	COG1181	Belongs to the D-alanine--D-alanine ligase family
SSA_2186	COG2918	glutathione biosynthetic process
SSA_2189	COG1397	ADP-ribosylglycohydrolase
SSA_2190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SSA_2191	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SSA_2194	COG3201	nicotinamide mononucleotide transporter
SSA_2200	COG4463	regulation of RNA biosynthetic process
SSA_2202	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SSA_2203	COG0052	Belongs to the universal ribosomal protein uS2 family
SSA_2209	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSA_2210	COG0564	pseudouridine synthase activity
SSA_2214	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SSA_2216	COG3475	LICD family
SSA_2218	COG1216	Glycosyl transferase, family 2
SSA_2219	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SSA_2224	COG4464	protein tyrosine phosphatase activity
SSA_2225	COG1316	TRANSCRIPTIONal
SSA_2226	COG0602	queuosine metabolic process
SSA_2230	COG1328	CTP reductase activity
SSA_2234	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SSA_2237	COG0285	dihydrofolate synthase activity
SSA_2239	COG3906	Belongs to the UPF0473 family
SSA_2240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SSA_2241	COG4472	Bacterial protein of unknown function (DUF965)
SSA_2244	COG1393	Belongs to the ArsC family
SSA_2245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SSA_2246	COG1546	Belongs to the CinA family
SSA_2246	COG1058	Belongs to the CinA family
SSA_2249	COG1136	(ABC) transporter
SSA_2253	COG2818	Glycosylase
SSA_2254	COG0632	four-way junction helicase activity
SSA_2255	COG1395	domain, Protein
SSA_2257	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SSA_2260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SSA_2261	COG1438	arginine binding
SSA_2262	COG0018	arginyl-trna synthetase
SSA_2263	COG1780	Probably involved in ribonucleotide reductase function
SSA_2265	COG0058	SHG alpha-glucan phosphorylase activity
SSA_2266	COG1640	4-alpha-glucanotransferase
SSA_2267	COG1609	Transcriptional regulator
SSA_2268	COG1523	belongs to the glycosyl hydrolase 13 family
SSA_2269	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSA_2284	COG0124	histidyl-tRNA synthetase
SSA_2285	COG2151	metal-sulfur cluster biosynthetic enzyme
SSA_2286	COG0129	dihydroxy-acid dehydratase activity
SSA_2287	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SSA_2295	COG4974	Belongs to the 'phage' integrase family
SSA_2298	COG3480	Lon protease (S16) C-terminal proteolytic domain
SSA_2302	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SSA_2318	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSA_2321	COG1230	cation diffusion facilitator family transporter
SSA_2323	COG2807	transmembrane transport
SSA_2325	COG2094	Belongs to the DNA glycosylase MPG family
SSA_2328	COG1349	DNA-binding transcription factor activity
SSA_2329	COG0561	phosphatase activity
SSA_2331	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SSA_2332	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSA_2333	COG1696	Membrane protein involved in D-alanine export
SSA_2339	COG1619	proteins homologs of microcin C7 resistance protein MccF
SSA_2343	COG1511	domain protein
SSA_2346	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSA_2349	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSA_2350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SSA_2351	COG1116	anion transmembrane transporter activity
SSA_2352	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SSA_2353	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SSA_2354	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SSA_2356	COG0305	Participates in initiation and elongation during chromosome replication
SSA_2357	COG0359	binds to the 23S rRNA
SSA_2359	COG0445	tRNA wobble uridine modification
SSA_2360	COG0482	sulfurtransferase activity
SSA_2361	COG1760	l-serine dehydratase
SSA_2362	COG1760	l-serine dehydratase
SSA_2363	COG0546	phosphoglycolate phosphatase activity
SSA_2365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SSA_2366	COG1122	ATPase activity
SSA_2367	COG1122	ATPase activity
SSA_2368	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SSA_2370	COG0612	Peptidase, M16
SSA_2371	COG0612	Peptidase, M16
SSA_2373	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SSA_2374	COG0516	GMP reductase activity
SSA_2374	COG0517	IMP dehydrogenase activity
SSA_2375	COG0180	Tryptophanyl-tRNA synthetase
SSA_2376	COG0488	(ABC) transporter
SSA_2380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SSA_2381	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSA_2382	COG1475	DNA binding
SSA_2391	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SSA_2392	COG0257	Belongs to the bacterial ribosomal protein bL36 family