locus-tag	class	description
GPZ88_RS00010	COG0492	ferredoxin-NADP+ reductase activity
GPZ88_RS00015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPZ88_RS00025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPZ88_RS00040	COG1837	Belongs to the UPF0109 family
GPZ88_RS00060	COG0577	efflux transmembrane transporter activity
GPZ88_RS00065	COG1136	(ABC) transporter
GPZ88_RS00080	COG0505	Belongs to the CarA family
GPZ88_RS00085	COG0540	Belongs to the ATCase OTCase family
GPZ88_RS00100	COG0564	pseudouridine synthase activity
GPZ88_RS00110	COG0583	DNA-binding transcription factor activity
GPZ88_RS00115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPZ88_RS00140	COG0301	tRNA thio-modification
GPZ88_RS00145	COG1104	cysteine desulfurase activity
GPZ88_RS00155	COG0285	dihydrofolate synthase activity
GPZ88_RS00170	COG0287	Prephenate dehydrogenase
GPZ88_RS00180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPZ88_RS00185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPZ88_RS00195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPZ88_RS00200	COG1368	sulfuric ester hydrolase activity
GPZ88_RS00205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPZ88_RS00210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPZ88_RS00215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GPZ88_RS00220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPZ88_RS00240	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPZ88_RS00255	COG3942	CHAP domain
GPZ88_RS00260	COG0463	Glycosyl transferase, family 2
GPZ88_RS00270	COG1368	sulfuric ester hydrolase activity
GPZ88_RS00275	COG3754	Rhamnan synthesis protein F
GPZ88_RS00280	COG1442	glycosyl transferase family 8
GPZ88_RS00280	COG1216	Glycosyl transferase, family 2
GPZ88_RS00295	COG1216	Glycosyl transferase, family 2
GPZ88_RS00295	COG1442	glycosyl transferase family 8
GPZ88_RS00305	COG2151	metal-sulfur cluster biosynthetic enzyme
GPZ88_RS00310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPZ88_RS00315	COG0358	DNA primase activity
GPZ88_RS00320	COG1970	mechanosensitive ion channel activity
GPZ88_RS00350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ88_RS00360	COG0058	SHG alpha-glucan phosphorylase activity
GPZ88_RS00365	COG1640	4-alpha-glucanotransferase
GPZ88_RS00370	COG1609	Transcriptional regulator
GPZ88_RS00380	COG1175	transmembrane transport
GPZ88_RS00385	COG3833	ABC-type maltose transport systems, permease component
GPZ88_RS00390	COG2816	NAD+ diphosphatase activity
GPZ88_RS00405	COG1126	abc transporter atp-binding protein
GPZ88_RS00410	COG1592	Rubrerythrin
GPZ88_RS00415	COG0488	(ABC) transporter
GPZ88_RS00435	COG1187	pseudouridine synthase activity
GPZ88_RS00440	COG4166	transmembrane transport
GPZ88_RS00445	COG4166	transmembrane transport
GPZ88_RS00450	COG0659	secondary active sulfate transmembrane transporter activity
GPZ88_RS00470	COG0590	tRNA wobble adenosine to inosine editing
GPZ88_RS00490	COG0454	-acetyltransferase
GPZ88_RS00495	COG0456	acetyltransferase
GPZ88_RS00510	COG2211	Major facilitator Superfamily
GPZ88_RS00530	COG1396	sequence-specific DNA binding
GPZ88_RS00545	COG0537	adenosine 5'-monophosphoramidase activity
GPZ88_RS00550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPZ88_RS00555	COG1316	TRANSCRIPTIONal
GPZ88_RS00560	COG0077	Prephenate dehydratase
GPZ88_RS00565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPZ88_RS00570	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPZ88_RS00575	COG0481	GTPase activity
GPZ88_RS00590	COG1518	maintenance of DNA repeat elements
GPZ88_RS00620	COG0647	UMP catabolic process
GPZ88_RS00630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPZ88_RS00645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GPZ88_RS00650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPZ88_RS00655	COG3442	glutamine amidotransferase
GPZ88_RS00660	COG3942	CHAP domain
GPZ88_RS00660	COG1388	LysM domain
GPZ88_RS00930	COG0582	viral genome integration into host DNA
GPZ88_RS00935	COG0148	phosphopyruvate hydratase activity
GPZ88_RS00950	COG1523	belongs to the glycosyl hydrolase 13 family
GPZ88_RS00965	COG0107	imidazoleglycerol-phosphate synthase activity
GPZ88_RS00975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPZ88_RS00985	COG0560	Phosphoserine phosphatase
GPZ88_RS00990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPZ88_RS01000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GPZ88_RS01015	COG0187	DNA topoisomerase II activity
GPZ88_RS01025	COG0772	Belongs to the SEDS family
GPZ88_RS01095	COG5280	Phage tail tape measure protein TP901
GPZ88_RS01095	COG3953	SLT domain
GPZ88_RS01295	COG0038	chloride channel
GPZ88_RS01305	COG0398	Pfam SNARE associated Golgi protein
GPZ88_RS01315	COG0716	FMN binding
GPZ88_RS01325	COG1454	alcohol dehydrogenase
GPZ88_RS01330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GPZ88_RS01340	COG0582	viral genome integration into host DNA
GPZ88_RS01385	COG1388	LysM domain
GPZ88_RS01385	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPZ88_RS01410	COG1660	Displays ATPase and GTPase activities
GPZ88_RS01420	COG1309	transcriptional regulator
GPZ88_RS01435	COG0251	oxidation-reduction process
GPZ88_RS01455	COG0017	Asparaginyl-tRNA synthetase
GPZ88_RS01465	COG0436	Aminotransferase
GPZ88_RS01475	COG1199	ATP-dependent helicase activity
GPZ88_RS01475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPZ88_RS01490	COG2177	Part of the ABC transporter FtsEX involved in
GPZ88_RS01495	COG2884	Cell division ATP-binding protein ftsE
GPZ88_RS01505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPZ88_RS01525	COG1078	dGTPase activity
GPZ88_RS01550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPZ88_RS01565	COG0772	Belongs to the SEDS family
GPZ88_RS01575	COG1164	Oligoendopeptidase f
GPZ88_RS01580	COG0386	Belongs to the glutathione peroxidase family
GPZ88_RS01600	COG0588	phosphoglycerate mutase activity
GPZ88_RS01625	COG1309	transcriptional regulator
GPZ88_RS01640	COG4443	Transcriptional Coactivator p15 (PC4)
GPZ88_RS01690	COG3091	SprT-like family
GPZ88_RS01695	COG2183	response to ionizing radiation
GPZ88_RS01705	COG0701	Predicted permease
GPZ88_RS01710	COG3689	TIGRFAM TIGR03943 family protein
GPZ88_RS01720	COG0552	protein localization to endoplasmic reticulum
GPZ88_RS01725	COG0561	phosphatase activity
GPZ88_RS01730	COG0561	phosphatase activity
GPZ88_RS01740	COG1196	nuclear chromosome segregation
GPZ88_RS01750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GPZ88_RS01755	COG5002	protein histidine kinase activity
GPZ88_RS01760	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS01765	COG1126	abc transporter atp-binding protein
GPZ88_RS01770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ88_RS01775	COG0765	amino acid transport
GPZ88_RS01780	COG0765	amino acid transport
GPZ88_RS01800	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS01805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GPZ88_RS01820	COG4716	Myosin-crossreactive antigen
GPZ88_RS01830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPZ88_RS01835	COG0438	transferase activity, transferring glycosyl groups
GPZ88_RS01845	COG1609	Transcriptional regulator
GPZ88_RS01850	COG0006	proline dipeptidase activity
GPZ88_RS01855	COG2816	NAD+ diphosphatase activity
GPZ88_RS01860	COG0583	DNA-binding transcription factor activity
GPZ88_RS01865	COG1811	Na channel or pump
GPZ88_RS01880	COG0778	Nitroreductase
GPZ88_RS01895	COG1846	Transcriptional regulator
GPZ88_RS01905	COG0557	exoribonuclease II activity
GPZ88_RS01920	COG2814	Major facilitator Superfamily
GPZ88_RS01925	COG0237	dephospho-CoA kinase activity
GPZ88_RS01930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPZ88_RS01940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPZ88_RS01945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPZ88_RS01950	COG0366	Alpha amylase catalytic
GPZ88_RS01965	COG1702	phosphate starvation-inducible protein PhoH
GPZ88_RS01970	COG4479	Belongs to the UPF0346 family
GPZ88_RS01980	COG2996	Protein conserved in bacteria
GPZ88_RS02010	COG1674	ftsk spoiiie
GPZ88_RS02025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPZ88_RS02040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPZ88_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ88_RS02070	COG1695	Transcriptional regulator
GPZ88_RS02080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPZ88_RS02080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPZ88_RS02095	COG0640	Transcriptional regulator
GPZ88_RS02100	COG0708	Exodeoxyribonuclease III
GPZ88_RS02120	COG2197	response regulator
GPZ88_RS02130	COG1393	Belongs to the ArsC family
GPZ88_RS02135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPZ88_RS02145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPZ88_RS02165	COG0004	ammonium transporteR
GPZ88_RS02180	COG1774	PSP1 C-terminal conserved region
GPZ88_RS02185	COG0470	DNA polymerase III
GPZ88_RS02195	COG0517	IMP dehydrogenase activity
GPZ88_RS02195	COG1227	inorganic diphosphatase activity
GPZ88_RS02225	COG4471	UPF0298 protein
GPZ88_RS02245	COG0583	DNA-binding transcription factor activity
GPZ88_RS02255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GPZ88_RS02260	COG0626	cystathionine gamma-synthase activity
GPZ88_RS02265	COG2244	polysaccharide biosynthetic process
GPZ88_RS02275	COG1120	ATPase activity
GPZ88_RS02280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPZ88_RS02285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ88_RS02290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ88_RS02305	COG3022	response to hydroperoxide
GPZ88_RS02320	COG1227	inorganic diphosphatase activity
GPZ88_RS02330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPZ88_RS02335	COG1253	flavin adenine dinucleotide binding
GPZ88_RS02340	COG2190	(PTS) system
GPZ88_RS02340	COG2211	Major facilitator Superfamily
GPZ88_RS02345	COG1119	ATPase activity
GPZ88_RS02355	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GPZ88_RS02360	COG1242	4 iron, 4 sulfur cluster binding
GPZ88_RS02365	COG0671	phosphoesterase, PA-phosphatase related
GPZ88_RS02370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GPZ88_RS02380	COG0531	amino acid
GPZ88_RS02385	COG0569	domain protein
GPZ88_RS02390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPZ88_RS02395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPZ88_RS02400	COG1187	pseudouridine synthase activity
GPZ88_RS02415	COG0582	viral genome integration into host DNA
GPZ88_RS02435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPZ88_RS02440	COG3763	UPF0154 protein
GPZ88_RS02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPZ88_RS02480	COG1254	Belongs to the acylphosphatase family
GPZ88_RS02495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPZ88_RS02505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPZ88_RS02525	COG1484	DNA-dependent DNA replication
GPZ88_RS02540	COG5002	protein histidine kinase activity
GPZ88_RS02545	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS02555	COG0501	Belongs to the peptidase M48B family
GPZ88_RS02560	COG1704	LemA family
GPZ88_RS02570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPZ88_RS02585	COG1122	ATPase activity
GPZ88_RS02595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPZ88_RS02600	COG1114	Component of the transport system for branched-chain amino acids
GPZ88_RS02605	COG2910	NAD(P)H-binding
GPZ88_RS02610	COG1959	2 iron, 2 sulfur cluster binding
GPZ88_RS02630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ88_RS02635	COG1473	amidohydrolase
GPZ88_RS02640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ88_RS02645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPZ88_RS02650	COG0217	transcriptional regulatory protein
GPZ88_RS02655	COG0789	Transcriptional regulator
GPZ88_RS02665	COG2020	methyltransferase activity
GPZ88_RS02670	COG2226	methyltransferase
GPZ88_RS02675	COG0799	negative regulation of ribosome biogenesis
GPZ88_RS02680	COG1713	HD superfamily hydrolase involved in NAD metabolism
GPZ88_RS02685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPZ88_RS02690	COG1534	Rna-binding protein
GPZ88_RS02695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPZ88_RS02700	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GPZ88_RS02710	COG2814	Major facilitator Superfamily
GPZ88_RS02730	COG0154	amidase activity
GPZ88_RS02735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GPZ88_RS02740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GPZ88_RS02745	COG0436	Aminotransferase
GPZ88_RS02755	COG0589	response to stress
GPZ88_RS02760	COG0561	phosphatase activity
GPZ88_RS02765	COG0252	asparaginase activity
GPZ88_RS02770	COG3655	Transcriptional regulator
GPZ88_RS02790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPZ88_RS02795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPZ88_RS02800	COG0736	holo-[acyl-carrier-protein] synthase activity
GPZ88_RS02805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPZ88_RS02810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPZ88_RS02820	COG1940	carbohydrate kinase activity
GPZ88_RS02825	COG1263	PTS System
GPZ88_RS02825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPZ88_RS02825	COG2190	(PTS) system
GPZ88_RS02830	COG1621	beta-fructofuranosidase activity
GPZ88_RS02835	COG1609	Transcriptional regulator
GPZ88_RS02840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPZ88_RS02850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPZ88_RS02860	COG2131	deaminase
GPZ88_RS02865	COG0006	proline dipeptidase activity
GPZ88_RS02895	COG3655	Transcriptional regulator
GPZ88_RS02905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPZ88_RS02945	COG0681	Belongs to the peptidase S26 family
GPZ88_RS02955	COG1194	a g-specific adenine glycosylase
GPZ88_RS02960	COG0431	NADPH-dependent FMN reductase
GPZ88_RS02960	COG3976	FMN-binding domain protein
GPZ88_RS02960	COG1053	succinate dehydrogenase
GPZ88_RS02990	COG3118	belongs to the thioredoxin family
GPZ88_RS03000	COG0157	Belongs to the NadC ModD family
GPZ88_RS03010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPZ88_RS03015	COG1193	negative regulation of DNA recombination
GPZ88_RS03035	COG0681	Belongs to the peptidase S26 family
GPZ88_RS03040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPZ88_RS03055	COG1882	Formate acetyltransferase
GPZ88_RS03070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GPZ88_RS03090	COG5002	protein histidine kinase activity
GPZ88_RS03100	COG0704	Plays a role in the regulation of phosphate uptake
GPZ88_RS03105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPZ88_RS03110	COG0581	inorganic phosphate transmembrane transporter activity
GPZ88_RS03115	COG0573	inorganic phosphate transmembrane transporter activity
GPZ88_RS03145	COG2081	HI0933 family
GPZ88_RS03170	COG0456	acetyltransferase
GPZ88_RS03175	COG1214	PFAM Peptidase M22, glycoprotease
GPZ88_RS03190	COG3942	CHAP domain
GPZ88_RS03195	COG0493	'glutamate synthase
GPZ88_RS03200	COG0067	glutamate synthase
GPZ88_RS03200	COG0070	glutamate synthase
GPZ88_RS03200	COG0069	glutamate synthase activity
GPZ88_RS03205	COG0174	glutamine synthetase
GPZ88_RS03210	COG0789	Transcriptional regulator
GPZ88_RS03220	COG0126	phosphoglycerate kinase activity
GPZ88_RS03225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPZ88_RS03230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPZ88_RS03235	COG0049	tRNA binding
GPZ88_RS03245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPZ88_RS03265	COG1564	THIamine pyrophosphokinase
GPZ88_RS03270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPZ88_RS03290	COG3290	protein histidine kinase activity
GPZ88_RS03295	COG3290	protein histidine kinase activity
GPZ88_RS03300	COG3290	protein histidine kinase activity
GPZ88_RS03365	COG2274	protein secretion by the type I secretion system
GPZ88_RS03370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPZ88_RS03380	COG1266	CAAX protease self-immunity
GPZ88_RS03410	COG0084	hydrolase, TatD family'
GPZ88_RS03415	COG1132	(ABC) transporter
GPZ88_RS03420	COG2223	nitrite transmembrane transporter activity
GPZ88_RS03430	COG0281	malic enzyme
GPZ88_RS03435	COG0583	DNA-binding transcription factor activity
GPZ88_RS03440	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GPZ88_RS03445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPZ88_RS03450	COG1696	Membrane protein involved in D-alanine export
GPZ88_RS03465	COG5002	protein histidine kinase activity
GPZ88_RS03470	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS03475	COG2207	Transcriptional regulator
GPZ88_RS03480	COG2273	Hydrolase Family 16
GPZ88_RS03490	COG0395	ABC-type sugar transport system, permease component
GPZ88_RS03515	COG2273	Hydrolase Family 16
GPZ88_RS03550	COG1131	(ABC) transporter
GPZ88_RS03565	COG0594	ribonuclease P activity
GPZ88_RS03575	COG0137	argininosuccinate synthase activity
GPZ88_RS03585	COG0444	Belongs to the ABC transporter superfamily
GPZ88_RS03590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ88_RS03595	COG0601	transmembrane transport
GPZ88_RS03600	COG4166	transmembrane transport
GPZ88_RS03605	COG2807	transmembrane transport
GPZ88_RS03615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPZ88_RS03625	COG4989	oxidoreductase activity
GPZ88_RS03640	COG0756	dUTP diphosphatase activity
GPZ88_RS03655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GPZ88_RS03665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPZ88_RS03670	COG1473	amidohydrolase
GPZ88_RS03675	COG2171	N-acyltransferase activity
GPZ88_RS03685	COG0166	Belongs to the GPI family
GPZ88_RS03700	COG1234	tRNA 3'-trailer cleavage
GPZ88_RS03705	COG1268	BioY protein
GPZ88_RS03715	COG0343	queuine tRNA-ribosyltransferase activity
GPZ88_RS03730	COG1832	CoA-binding protein
GPZ88_RS03735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPZ88_RS03735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPZ88_RS03760	COG1979	alcohol dehydrogenase
GPZ88_RS03765	COG1464	Belongs to the NlpA lipoprotein family
GPZ88_RS03770	COG2011	ABC-type metal ion transport system permease component
GPZ88_RS03775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPZ88_RS03780	COG1959	2 iron, 2 sulfur cluster binding
GPZ88_RS03790	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPZ88_RS03790	COG2918	glutathione biosynthetic process
GPZ88_RS03795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPZ88_RS03800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPZ88_RS03810	COG1131	(ABC) transporter
GPZ88_RS03820	COG3290	protein histidine kinase activity
GPZ88_RS03840	COG0542	response to heat
GPZ88_RS03845	COG4463	regulation of RNA biosynthetic process
GPZ88_RS03855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPZ88_RS03875	COG1396	sequence-specific DNA binding
GPZ88_RS03880	COG3590	peptidase
GPZ88_RS03910	COG1309	transcriptional regulator
GPZ88_RS03915	COG0602	queuosine metabolic process
GPZ88_RS03930	COG1328	CTP reductase activity
GPZ88_RS03930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPZ88_RS03950	COG4472	Bacterial protein of unknown function (DUF965)
GPZ88_RS03955	COG1393	Belongs to the ArsC family
GPZ88_RS03965	COG1546	Belongs to the CinA family
GPZ88_RS03965	COG1058	Belongs to the CinA family
GPZ88_RS03975	COG0519	Catalyzes the synthesis of GMP from XMP
GPZ88_RS04020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPZ88_RS04025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPZ88_RS04045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPZ88_RS04060	COG0366	Alpha amylase catalytic
GPZ88_RS04070	COG2188	Transcriptional regulator
GPZ88_RS04090	COG0681	Belongs to the peptidase S26 family
GPZ88_RS04145	COG1674	ftsk spoiiie
GPZ88_RS04150	COG4499	WXG100 protein secretion system (Wss), protein YukC
GPZ88_RS04165	COG4842	Belongs to the WXG100 family
GPZ88_RS04185	COG3759	membrane
GPZ88_RS04190	COG1511	domain protein
GPZ88_RS04190	COG1511	domain protein
GPZ88_RS04210	COG4466	Protein conserved in bacteria
GPZ88_RS04215	COG0305	Participates in initiation and elongation during chromosome replication
GPZ88_RS04230	COG0445	tRNA wobble uridine modification
GPZ88_RS04240	COG1760	l-serine dehydratase
GPZ88_RS04245	COG1760	l-serine dehydratase
GPZ88_RS04255	COG0741	lytic transglycosylase activity
GPZ88_RS04270	COG1122	ATPase activity
GPZ88_RS04280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPZ88_RS04290	COG0612	Peptidase, M16
GPZ88_RS04295	COG0612	Peptidase, M16
GPZ88_RS04305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPZ88_RS04315	COG0517	IMP dehydrogenase activity
GPZ88_RS04315	COG0516	GMP reductase activity
GPZ88_RS04330	COG0488	(ABC) transporter
GPZ88_RS04360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPZ88_RS04365	COG1475	DNA binding
GPZ88_RS04375	COG0592	DNA-directed DNA polymerase activity
GPZ88_RS04380	COG1597	lipid kinase activity
GPZ88_RS04390	COG0012	GTP binding
GPZ88_RS04400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPZ88_RS04410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPZ88_RS04440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPZ88_RS04615	COG1792	Involved in formation and maintenance of cell shape
GPZ88_RS04625	COG3942	CHAP domain
GPZ88_RS04635	COG0436	Aminotransferase
GPZ88_RS04645	COG0416	fatty acid biosynthetic process
GPZ88_RS04650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPZ88_RS04655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPZ88_RS04660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPZ88_RS04675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPZ88_RS04680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPZ88_RS04695	COG1683	Conserved Protein
GPZ88_RS04700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPZ88_RS04715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPZ88_RS04725	COG2255	four-way junction helicase activity
GPZ88_RS04735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPZ88_RS04745	COG2755	lipolytic protein G-D-S-L family
GPZ88_RS04745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPZ88_RS04755	COG0534	Mate efflux family protein
GPZ88_RS04760	COG0051	transcription antitermination factor activity, RNA binding
GPZ88_RS04770	COG0088	Forms part of the polypeptide exit tunnel
GPZ88_RS04775	COG0089	rRNA binding
GPZ88_RS04800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPZ88_RS04805	COG0255	Belongs to the universal ribosomal protein uL29 family
GPZ88_RS04820	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPZ88_RS04830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPZ88_RS04850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPZ88_RS04855	COG1841	ribosomal large subunit assembly
GPZ88_RS04865	COG0201	protein transport
GPZ88_RS04890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPZ88_RS04895	COG0202	RNA polymerase activity
GPZ88_RS04900	COG0203	ribosomal protein L17
GPZ88_RS05010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPZ88_RS05020	COG1121	(ABC) transporter
GPZ88_RS05025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPZ88_RS05045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPZ88_RS05055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPZ88_RS05060	COG1459	type II secretion system
GPZ88_RS05065	COG4537	Required for transformation and DNA binding
GPZ88_RS05120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPZ88_RS05125	COG1363	Peptidase, m42
GPZ88_RS05135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPZ88_RS05140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPZ88_RS05155	COG0561	phosphatase activity
GPZ88_RS05170	COG4585	Histidine kinase
GPZ88_RS05175	COG2197	response regulator
GPZ88_RS05195	COG3715	PTS system
GPZ88_RS05200	COG3716	PTS system mannose fructose sorbose family IID component
GPZ88_RS05210	COG1396	sequence-specific DNA binding
GPZ88_RS05225	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPZ88_RS05230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPZ88_RS05230	COG1116	anion transmembrane transporter activity
GPZ88_RS05245	COG1396	sequence-specific DNA binding
GPZ88_RS05255	COG0564	pseudouridine synthase activity
GPZ88_RS05265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPZ88_RS05290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPZ88_RS05295	COG4667	esterase of the alpha-beta hydrolase superfamily
GPZ88_RS05305	COG2017	converts alpha-aldose to the beta-anomer
GPZ88_RS05310	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPZ88_RS05330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPZ88_RS05335	COG0456	acetyltransferase
GPZ88_RS05355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPZ88_RS05365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPZ88_RS05365	COG2190	(PTS) system
GPZ88_RS05365	COG1263	PTS System
GPZ88_RS05375	COG1363	Peptidase, m42
GPZ88_RS05385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPZ88_RS05390	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPZ88_RS05395	COG2723	6-phospho-beta-galactosidase activity
GPZ88_RS05400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPZ88_RS05405	COG2188	Transcriptional regulator
GPZ88_RS05410	COG1482	cell wall glycoprotein biosynthetic process
GPZ88_RS05420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPZ88_RS05425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPZ88_RS05435	COG2188	Transcriptional regulator
GPZ88_RS05440	COG1940	carbohydrate kinase activity
GPZ88_RS05460	COG3842	ATPase activity
GPZ88_RS05470	COG0698	ribose 5-phosphate isomerase
GPZ88_RS05495	COG3711	transcriptional antiterminator
GPZ88_RS05500	COG2723	6-phospho-beta-galactosidase activity
GPZ88_RS05505	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPZ88_RS05510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPZ88_RS05510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPZ88_RS05515	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GPZ88_RS05520	COG1131	(ABC) transporter
GPZ88_RS05530	COG2207	Transcriptional regulator
GPZ88_RS05535	COG3345	alpha-galactosidase
GPZ88_RS05540	COG1653	transport
GPZ88_RS05545	COG1175	transmembrane transport
GPZ88_RS05550	COG0395	ABC-type sugar transport system, permease component
GPZ88_RS05555	COG0366	Alpha amylase catalytic
GPZ88_RS05560	COG0366	Alpha amylase catalytic
GPZ88_RS05630	COG1609	Transcriptional regulator
GPZ88_RS05635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPZ88_RS05640	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GPZ88_RS05645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPZ88_RS05655	COG1862	Preprotein translocase
GPZ88_RS05660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPZ88_RS05665	COG4589	Belongs to the CDS family
GPZ88_RS05725	COG1674	ftsk spoiiie
GPZ88_RS05735	COG2946	Replication initiation factor
GPZ88_RS05765	COG0791	NLP P60 protein
GPZ88_RS05765	COG0741	lytic transglycosylase activity
GPZ88_RS05820	COG1454	alcohol dehydrogenase
GPZ88_RS05820	COG1012	belongs to the aldehyde dehydrogenase family
GPZ88_RS05830	COG1185	polyribonucleotide nucleotidyltransferase activity
GPZ88_RS05840	COG1045	serine acetyltransferase
GPZ88_RS05850	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GPZ88_RS05885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPZ88_RS05925	COG3830	Belongs to the UPF0237 family
GPZ88_RS05935	COG0588	phosphoglycerate mutase activity
GPZ88_RS05940	COG1876	peptidase activity
GPZ88_RS05945	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPZ88_RS05960	COG0443	Heat shock 70 kDa protein
GPZ88_RS06000	COG0668	transmembrane transport
GPZ88_RS06015	COG0504	CTP synthase activity
GPZ88_RS06030	COG0191	fructose-bisphosphate aldolase activity
GPZ88_RS06040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPZ88_RS06050	COG1461	Dihydroxyacetone kinase
GPZ88_RS06055	COG0129	dihydroxy-acid dehydratase activity
GPZ88_RS06060	COG0028	Belongs to the TPP enzyme family
GPZ88_RS06065	COG0440	acetolactate synthase activity
GPZ88_RS06075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GPZ88_RS06090	COG1126	abc transporter atp-binding protein
GPZ88_RS06095	COG0765	amino acid transport
GPZ88_RS06115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPZ88_RS06125	COG0719	Fe-S assembly protein
GPZ88_RS06130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPZ88_RS06140	COG0719	Fe-S assembly protein
GPZ88_RS06145	COG1686	Belongs to the peptidase S11 family
GPZ88_RS06150	COG4166	transmembrane transport
GPZ88_RS06155	COG0601	transmembrane transport
GPZ88_RS06160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ88_RS06165	COG0444	Belongs to the ABC transporter superfamily
GPZ88_RS06170	COG4608	Belongs to the ABC transporter superfamily
GPZ88_RS06205	COG0527	aspartate kinase activity
GPZ88_RS06210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPZ88_RS06215	COG1024	Enoyl-CoA hydratase
GPZ88_RS06225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPZ88_RS06240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPZ88_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ88_RS06250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPZ88_RS06265	COG0439	Biotin carboxylase
GPZ88_RS06280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPZ88_RS06290	COG3716	PTS system mannose fructose sorbose family IID component
GPZ88_RS06295	COG3715	PTS system
GPZ88_RS06305	COG0561	phosphatase activity
GPZ88_RS06320	COG2252	PERMEase
GPZ88_RS06325	COG0802	atpase or kinase
GPZ88_RS06335	COG1316	TRANSCRIPTIONal
GPZ88_RS06345	COG0537	adenosine 5'-monophosphoramidase activity
GPZ88_RS06350	COG1131	(ABC) transporter
GPZ88_RS06355	COG4473	ABC transporter
GPZ88_RS06365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPZ88_RS06390	COG0195	Participates in both transcription termination and antitermination
GPZ88_RS06395	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GPZ88_RS06405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPZ88_RS06410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPZ88_RS06415	COG1611	Belongs to the LOG family
GPZ88_RS06430	COG2217	Heavy metal translocating P-type atpase
GPZ88_RS06440	COG2860	membrane
GPZ88_RS06445	COG0561	phosphatase activity
GPZ88_RS06470	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPZ88_RS06510	COG1131	(ABC) transporter
GPZ88_RS06520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPZ88_RS06530	COG0275	rRNA processing
GPZ88_RS06540	COG0768	penicillin binding
GPZ88_RS06545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPZ88_RS06550	COG0513	Belongs to the DEAD box helicase family
GPZ88_RS06565	COG1126	abc transporter atp-binding protein
GPZ88_RS06575	COG0492	ferredoxin-NADP+ reductase activity
GPZ88_RS06580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPZ88_RS06590	COG3579	cysteine-type endopeptidase activity
GPZ88_RS06595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPZ88_RS06600	COG3331	DNA recombination
GPZ88_RS06610	COG3599	regulation of cell shape
GPZ88_RS06620	COG0116	Belongs to the methyltransferase superfamily
GPZ88_RS06635	COG1854	S-ribosylhomocysteine lyase activity
GPZ88_RS06655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPZ88_RS06665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPZ88_RS06665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPZ88_RS06675	COG2815	serine threonine protein kinase
GPZ88_RS06675	COG0515	serine threonine protein kinase
GPZ88_RS06685	COG4585	Histidine kinase
GPZ88_RS06690	COG2197	response regulator
GPZ88_RS06700	COG1098	S1 RNA binding domain
GPZ88_RS06710	COG1739	Uncharacterized protein family UPF0029
GPZ88_RS06715	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GPZ88_RS06720	COG1040	competence protein
GPZ88_RS06790	COG3557	Belongs to the UPF0374 family
GPZ88_RS06795	COG2137	regulation of response to DNA damage stimulus
GPZ88_RS06805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPZ88_RS06820	COG1428	Deoxynucleoside kinase
GPZ88_RS06845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPZ88_RS06890	COG4716	Myosin-crossreactive antigen
GPZ88_RS06915	COG0742	ribosomal rna small subunit methyltransferase
GPZ88_RS06920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPZ88_RS06925	COG3480	Lon protease (S16) C-terminal proteolytic domain
GPZ88_RS06935	COG0737	Belongs to the 5'-nucleotidase family
GPZ88_RS06940	COG4470	Protein conserved in bacteria
GPZ88_RS06955	COG1132	(ABC) transporter
GPZ88_RS06960	COG1132	(ABC) transporter
GPZ88_RS06965	COG1131	(ABC) transporter
GPZ88_RS06975	COG4585	Histidine kinase
GPZ88_RS06980	COG2197	response regulator
GPZ88_RS06990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPZ88_RS06995	COG0512	Glutamine amidotransferase of anthranilate synthase
GPZ88_RS07010	COG0135	phosphoribosylanthranilate isomerase activity
GPZ88_RS07015	COG0133	tryptophan synthase activity
GPZ88_RS07020	COG0159	tryptophan synthase activity
GPZ88_RS07025	COG1914	H( )-stimulated, divalent metal cation uptake system
GPZ88_RS07035	COG0783	Belongs to the Dps family
GPZ88_RS07045	COG1940	carbohydrate kinase activity
GPZ88_RS07050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPZ88_RS07090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPZ88_RS07095	COG1799	cell septum assembly
GPZ88_RS07110	COG3599	regulation of cell shape
GPZ88_RS07130	COG0542	response to heat
GPZ88_RS07145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPZ88_RS07150	COG4703	Protein of unknown function (DUF1797)
GPZ88_RS07155	COG0765	amino acid transport
GPZ88_RS07160	COG1126	abc transporter atp-binding protein
GPZ88_RS07170	COG1918	ferrous iron import across plasma membrane
GPZ88_RS07170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GPZ88_RS07185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPZ88_RS07220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GPZ88_RS07225	COG1438	arginine binding
GPZ88_RS07230	COG0497	DNA recombination
GPZ88_RS07235	COG1307	EDD domain protein, DegV family
GPZ88_RS07240	COG2755	lipolytic protein G-D-S-L family
GPZ88_RS07245	COG4698	Protein conserved in bacteria
GPZ88_RS07260	COG3104	oligopeptide transport
GPZ88_RS07265	COG0167	dihydroorotate dehydrogenase activity
GPZ88_RS07270	COG0640	Transcriptional regulator
GPZ88_RS07275	COG2217	Heavy metal translocating P-type atpase
GPZ88_RS07280	COG0588	phosphoglycerate mutase activity
GPZ88_RS07285	COG1827	regulation of RNA biosynthetic process
GPZ88_RS07295	COG0768	penicillin binding
GPZ88_RS07300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPZ88_RS07310	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPZ88_RS07320	COG0385	Bile acid
GPZ88_RS07325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPZ88_RS07340	COG0513	Belongs to the DEAD box helicase family
GPZ88_RS07350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPZ88_RS07355	COG0204	Acyl-transferase
GPZ88_RS07360	COG1555	photosystem II stabilization
GPZ88_RS07360	COG1596	polysaccharide export
GPZ88_RS07365	COG0658	competence protein
GPZ88_RS07365	COG2333	competence protein COMEC
GPZ88_RS07370	COG1466	dna polymerase III delta subunit
GPZ88_RS07380	COG0217	transcriptional regulatory protein
GPZ88_RS07385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPZ88_RS07395	COG0363	glucosamine-6-phosphate deaminase activity
GPZ88_RS07400	COG1187	pseudouridine synthase activity
GPZ88_RS07420	COG0546	phosphoglycolate phosphatase activity
GPZ88_RS07425	COG4122	O-methyltransferase activity
GPZ88_RS07430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPZ88_RS07435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPZ88_RS07455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPZ88_RS07460	COG0436	Aminotransferase
GPZ88_RS07470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GPZ88_RS07475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPZ88_RS07480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPZ88_RS07490	COG1476	TRANSCRIPTIONal
GPZ88_RS07500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPZ88_RS07500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPZ88_RS07510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPZ88_RS07510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPZ88_RS07520	COG3859	Proton-coupled thiamine transporter YuaJ
GPZ88_RS07525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPZ88_RS07530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPZ88_RS07535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPZ88_RS07540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPZ88_RS07545	COG0372	Belongs to the citrate synthase family
GPZ88_RS07575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPZ88_RS07610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPZ88_RS07615	COG0066	3-isopropylmalate dehydratase activity
GPZ88_RS07620	COG1956	GAF domain-containing protein
GPZ88_RS07625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GPZ88_RS07635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GPZ88_RS07635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GPZ88_RS07640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPZ88_RS07650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPZ88_RS07655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPZ88_RS07660	COG4109	DRTGG domain
GPZ88_RS07665	COG0024	Methionine aminopeptidase
GPZ88_RS07675	COG2246	polysaccharide biosynthetic process
GPZ88_RS07680	COG4708	membrane
GPZ88_RS07685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPZ88_RS07690	COG1597	lipid kinase activity
GPZ88_RS07740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPZ88_RS07770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GPZ88_RS07775	COG1074	ATP-dependent DNA helicase activity
GPZ88_RS07805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPZ88_RS07820	COG0300	oxidoreductase activity
GPZ88_RS07825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GPZ88_RS07825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPZ88_RS07830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GPZ88_RS07850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPZ88_RS07855	COG2384	SAM-dependent methyltransferase
GPZ88_RS07865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPZ88_RS07875	COG1088	dTDP-glucose 4,6-dehydratase activity
GPZ88_RS07880	COG1051	belongs to the nudix hydrolase family
GPZ88_RS07885	COG0628	permease
GPZ88_RS07890	COG0457	Tetratricopeptide repeat
GPZ88_RS07900	COG0028	Belongs to the TPP enzyme family
GPZ88_RS07905	COG3527	Alpha-acetolactate decarboxylase
GPZ88_RS07910	COG0531	amino acid
GPZ88_RS07915	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GPZ88_RS07920	COG0583	DNA-binding transcription factor activity
GPZ88_RS07925	COG1126	abc transporter atp-binding protein
GPZ88_RS07930	COG0765	amino acid transport
GPZ88_RS07940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPZ88_RS07945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPZ88_RS07950	COG4187	Peptidase family M20/M25/M40
GPZ88_RS07960	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPZ88_RS07965	COG3842	ATPase activity
GPZ88_RS07980	COG0488	(ABC) transporter
GPZ88_RS07985	COG1396	sequence-specific DNA binding
GPZ88_RS08000	COG1132	(ABC) transporter
GPZ88_RS08005	COG1132	(ABC) transporter
GPZ88_RS08015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GPZ88_RS08025	COG0789	Transcriptional regulator
GPZ88_RS08055	COG1136	(ABC) transporter
GPZ88_RS08060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPZ88_RS08065	COG1011	Hydrolase
GPZ88_RS08075	COG0583	DNA-binding transcription factor activity
GPZ88_RS08080	COG2855	membrane
GPZ88_RS08085	COG1012	belongs to the aldehyde dehydrogenase family
GPZ88_RS08090	COG0322	excinuclease ABC activity
GPZ88_RS08110	COG1573	uracil-dna glycosylase
GPZ88_RS08115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPZ88_RS08130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPZ88_RS08165	COG1442	glycosyl transferase family 8
GPZ88_RS08165	COG1216	Glycosyl transferase, family 2
GPZ88_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ88_RS08175	COG1316	TRANSCRIPTIONal
GPZ88_RS08195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPZ88_RS08200	COG0438	transferase activity, transferring glycosyl groups
GPZ88_RS08210	COG1215	transferase activity, transferring glycosyl groups
GPZ88_RS08235	COG1091	dTDP-4-dehydrorhamnose reductase activity
GPZ88_RS08260	COG0167	dihydroorotate dehydrogenase activity
GPZ88_RS08265	COG0284	orotidine-5'-phosphate decarboxylase activity
GPZ88_RS08270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPZ88_RS08280	COG1881	PFAM PEBP family protein
GPZ88_RS08285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPZ88_RS08300	COG0187	DNA topoisomerase II activity
GPZ88_RS08310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPZ88_RS08315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPZ88_RS08335	COG0539	negative regulation of cytoplasmic translation
GPZ88_RS08345	COG1346	cytolysis
GPZ88_RS08350	COG1380	Effector of murein hydrolase LrgA
GPZ88_RS08370	COG1131	(ABC) transporter
GPZ88_RS08375	COG1725	Transcriptional regulator
GPZ88_RS08385	COG0205	6-phosphofructokinase activity
GPZ88_RS08390	COG0469	pyruvate kinase activity
GPZ88_RS08405	COG2824	Alkylphosphonate utilization operon protein PhnA
GPZ88_RS08410	COG0765	amino acid transport
GPZ88_RS08415	COG1126	abc transporter atp-binding protein
GPZ88_RS08425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPZ88_RS08430	COG1115	amino acid carrier protein
GPZ88_RS08435	COG2723	6-phospho-beta-galactosidase activity
GPZ88_RS08440	COG0406	alpha-ribazole phosphatase activity
GPZ88_RS08445	COG0628	permease
GPZ88_RS08455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GPZ88_RS08465	COG1104	cysteine desulfurase activity
GPZ88_RS08475	COG4116	CYTH
GPZ88_RS08480	COG2357	RelA SpoT domain protein
GPZ88_RS08490	COG0564	pseudouridine synthase activity
GPZ88_RS08495	COG0280	phosphate acetyltransferase
GPZ88_RS08500	COG4221	oxidoreductase activity
GPZ88_RS08510	COG0561	phosphatase activity
GPZ88_RS08515	COG2723	6-phospho-beta-galactosidase activity
GPZ88_RS08520	COG1136	(ABC) transporter
GPZ88_RS08525	COG0577	efflux transmembrane transporter activity
GPZ88_RS08530	COG0516	GMP reductase activity
GPZ88_RS08540	COG2233	PERMEase
GPZ88_RS08565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPZ88_RS08570	COG2890	protein-(glutamine-N5) methyltransferase activity
GPZ88_RS08575	COG0009	L-threonylcarbamoyladenylate synthase
GPZ88_RS08580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPZ88_RS08600	COG1132	(ABC) transporter
GPZ88_RS08615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GPZ88_RS08620	COG0022	dehydrogenase e1 component
GPZ88_RS08620	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPZ88_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPZ88_RS08645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ88_RS08650	COG0095	Lipoate-protein ligase
GPZ88_RS08680	COG1937	Protein conserved in bacteria
GPZ88_RS08690	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPZ88_RS08695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPZ88_RS08700	COG1418	mRNA catabolic process
GPZ88_RS08710	COG0519	Catalyzes the synthesis of GMP from XMP
GPZ88_RS08710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPZ88_RS08755	COG1396	sequence-specific DNA binding
GPZ88_RS08760	COG0366	Alpha amylase catalytic
GPZ88_RS08760	COG5263	repeat protein
GPZ88_RS08775	COG0534	Mate efflux family protein
GPZ88_RS08780	COG1461	Dihydroxyacetone kinase
GPZ88_RS08785	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GPZ88_RS08800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPZ88_RS08835	COG2188	Transcriptional regulator
GPZ88_RS08845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPZ88_RS08875	COG1129	ABC transporter
GPZ88_RS08880	COG4974	Belongs to the 'phage' integrase family
GPZ88_RS08890	COG2205	protein histidine kinase activity
GPZ88_RS08895	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS08900	COG0577	efflux transmembrane transporter activity
GPZ88_RS08905	COG1136	(ABC) transporter
GPZ88_RS08930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPZ88_RS08935	COG0758	DNA mediated transformation
GPZ88_RS08940	COG0110	maltose O-acetyltransferase activity
GPZ88_RS08945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPZ88_RS08950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPZ88_RS09005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPZ88_RS09050	COG0488	(ABC) transporter
GPZ88_RS09065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ88_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPZ88_RS09075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPZ88_RS09080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPZ88_RS09090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPZ88_RS09095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPZ88_RS09100	COG4684	Psort location CytoplasmicMembrane, score
GPZ88_RS09105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPZ88_RS09125	COG0346	lactoylglutathione lyase activity
GPZ88_RS09130	COG3764	Sortase (surface protein transpeptidase)
GPZ88_RS09165	COG1744	ABC transporter substrate-binding protein PnrA-like
GPZ88_RS09175	COG2813	Specifically methylates the guanine in position
GPZ88_RS09180	COG1072	(Pantothenic acid kinase))
GPZ88_RS09190	COG5002	protein histidine kinase activity
GPZ88_RS09195	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS09205	COG0704	Plays a role in the regulation of phosphate uptake
GPZ88_RS09210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPZ88_RS09215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPZ88_RS09220	COG0581	inorganic phosphate transmembrane transporter activity
GPZ88_RS09225	COG0573	inorganic phosphate transmembrane transporter activity
GPZ88_RS09235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPZ88_RS09235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPZ88_RS09240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPZ88_RS09260	COG0483	inositol monophosphate 1-phosphatase activity
GPZ88_RS09265	COG4476	Belongs to the UPF0223 family
GPZ88_RS09270	COG1393	Belongs to the ArsC family
GPZ88_RS09275	COG0196	riboflavin kinase activity
GPZ88_RS09280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPZ88_RS09310	COG0577	efflux transmembrane transporter activity
GPZ88_RS09310	COG1136	(ABC) transporter
GPZ88_RS09330	COG2873	o-acetylhomoserine
GPZ88_RS09340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPZ88_RS09350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPZ88_RS09385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ88_RS09390	COG1115	amino acid carrier protein
GPZ88_RS09395	COG0561	phosphatase activity
GPZ88_RS09415	COG0561	phosphatase activity
GPZ88_RS09420	COG0656	L-ascorbic acid biosynthetic process
GPZ88_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ88_RS09430	COG0110	maltose O-acetyltransferase activity
GPZ88_RS09440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPZ88_RS09450	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPZ88_RS09455	COG3711	transcriptional antiterminator
GPZ88_RS09455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPZ88_RS09460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPZ88_RS09485	COG2723	6-phospho-beta-galactosidase activity
GPZ88_RS09500	COG2207	Transcriptional regulator
GPZ88_RS09505	COG1263	PTS System
GPZ88_RS09505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPZ88_RS09505	COG2190	(PTS) system
GPZ88_RS09510	COG3711	transcriptional antiterminator
GPZ88_RS09515	COG0038	chloride channel
GPZ88_RS09525	COG1177	transmembrane transport
GPZ88_RS09530	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPZ88_RS09540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPZ88_RS09565	COG0285	dihydrofolate synthase activity
GPZ88_RS09570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPZ88_RS09575	COG2962	Rard protein
GPZ88_RS09590	COG0726	polysaccharide deacetylase
GPZ88_RS09600	COG1309	transcriptional regulator
GPZ88_RS09615	COG0222	ribosome binding
GPZ88_RS09620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPZ88_RS09635	COG2040	homocysteine
GPZ88_RS09640	COG0833	amino acid
GPZ88_RS09655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPZ88_RS09660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPZ88_RS09665	COG3425	synthase
GPZ88_RS09680	COG1272	protein, Hemolysin III
GPZ88_RS09710	COG1126	abc transporter atp-binding protein
GPZ88_RS09715	COG0765	amino acid transport
GPZ88_RS09725	COG1126	abc transporter atp-binding protein
GPZ88_RS09730	COG0765	amino acid transport
GPZ88_RS09735	COG0765	amino acid transport
GPZ88_RS09740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ88_RS09750	COG0583	DNA-binding transcription factor activity
GPZ88_RS09755	COG0656	L-ascorbic acid biosynthetic process
GPZ88_RS09760	COG5002	protein histidine kinase activity
GPZ88_RS09765	COG0745	RESPONSE REGULATOR receiver
GPZ88_RS09770	COG2357	RelA SpoT domain protein
GPZ88_RS09775	COG1132	(ABC) transporter
GPZ88_RS09790	COG0242	peptide deformylase activity
GPZ88_RS09795	COG1247	-acetyltransferase
GPZ88_RS09800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPZ88_RS09810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPZ88_RS09815	COG0602	queuosine metabolic process
GPZ88_RS09820	COG0720	synthase
GPZ88_RS09825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPZ88_RS09830	COG1132	(ABC) transporter
GPZ88_RS09840	COG0488	(ABC) transporter
GPZ88_RS09865	COG1388	LysM domain
GPZ88_RS09865	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPZ88_RS09870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPZ88_RS09875	COG0646	methionine synthase
GPZ88_RS09875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPZ88_RS09880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPZ88_RS09885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPZ88_RS09885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPZ88_RS09885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPZ88_RS09890	COG1105	Belongs to the carbohydrate kinase PfkB family
GPZ88_RS09975	COG4974	Belongs to the 'phage' integrase family
GPZ88_RS10015	COG4974	Belongs to the 'phage' integrase family
GPZ88_RS10065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPZ88_RS10210	COG2003	Belongs to the UPF0758 family
GPZ88_RS10235	COG3764	Sortase (surface protein transpeptidase)