locus-tag	class	description
D7D53_RS00010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7D53_RS00030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D7D53_RS00045	COG0201	protein transport
D7D53_RS00055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D7D53_RS00060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7D53_RS00070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D7D53_RS00075	COG0202	RNA polymerase activity
D7D53_RS00085	COG3830	Belongs to the UPF0237 family
D7D53_RS00090	COG2848	UPF0210 protein
D7D53_RS00095	COG0588	phosphoglycerate mutase activity
D7D53_RS00120	COG2255	four-way junction helicase activity
D7D53_RS00130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D7D53_RS00135	COG4589	Belongs to the CDS family
D7D53_RS00140	COG0750	zinc metalloprotease
D7D53_RS00150	COG2723	6-phospho-beta-galactosidase activity
D7D53_RS00155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7D53_RS00165	COG1523	belongs to the glycosyl hydrolase 13 family
D7D53_RS00195	COG0802	atpase or kinase
D7D53_RS00205	COG1316	TRANSCRIPTIONal
D7D53_RS00245	COG1132	(ABC) transporter
D7D53_RS00285	COG3620	sequence-specific DNA binding
D7D53_RS00390	COG3843	relaxase mobilization nuclease domain protein
D7D53_RS00405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7D53_RS00415	COG1461	Dihydroxyacetone kinase
D7D53_RS00430	COG1131	(ABC) transporter
D7D53_RS00435	COG0842	Transport permease protein
D7D53_RS00440	COG4585	Histidine kinase
D7D53_RS00445	COG2197	response regulator
D7D53_RS00470	COG0028	Belongs to the TPP enzyme family
D7D53_RS00475	COG0440	acetolactate synthase activity
D7D53_RS00485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D7D53_RS00500	COG0765	amino acid transport
D7D53_RS00515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7D53_RS00520	COG1882	Formate acetyltransferase
D7D53_RS00535	COG1131	(ABC) transporter
D7D53_RS00565	COG0366	Alpha amylase catalytic
D7D53_RS00575	COG4166	transmembrane transport
D7D53_RS00585	COG4464	protein tyrosine phosphatase activity
D7D53_RS00590	COG3944	biosynthesis protein
D7D53_RS00595	COG0489	protein tyrosine kinase activity
D7D53_RS00615	COG1216	Glycosyl transferase, family 2
D7D53_RS00615	COG1442	glycosyl transferase family 8
D7D53_RS00625	COG0438	transferase activity, transferring glycosyl groups
D7D53_RS00630	COG0438	transferase activity, transferring glycosyl groups
D7D53_RS00645	COG0562	UDP-galactopyranose mutase
D7D53_RS00650	COG3594	Acyltransferase
D7D53_RS00660	COG4166	transmembrane transport
D7D53_RS00665	COG0366	Alpha amylase catalytic
D7D53_RS00665	COG0366	Alpha amylase catalytic
D7D53_RS00665	COG0366	Alpha amylase catalytic
D7D53_RS00675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7D53_RS00700	COG0116	Belongs to the methyltransferase superfamily
D7D53_RS00710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D7D53_RS00715	COG0745	RESPONSE REGULATOR receiver
D7D53_RS00730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D7D53_RS00755	COG4585	Histidine kinase
D7D53_RS00760	COG2197	response regulator
D7D53_RS00775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7D53_RS00780	COG0681	Belongs to the peptidase S26 family
D7D53_RS00805	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D7D53_RS00810	COG3421	Type III restriction
D7D53_RS00815	COG1115	amino acid carrier protein
D7D53_RS00840	COG0527	aspartate kinase activity
D7D53_RS00850	COG1024	Enoyl-CoA hydratase
D7D53_RS00865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7D53_RS00875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D7D53_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
D7D53_RS00885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7D53_RS00900	COG0439	Biotin carboxylase
D7D53_RS00905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D7D53_RS00945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D7D53_RS00955	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D7D53_RS00960	COG0668	transmembrane transport
D7D53_RS00975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D7D53_RS00980	COG1534	Rna-binding protein
D7D53_RS00985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D7D53_RS00990	COG1713	HD superfamily hydrolase involved in NAD metabolism
D7D53_RS01000	COG0799	negative regulation of ribosome biogenesis
D7D53_RS01005	COG2226	methyltransferase
D7D53_RS01020	COG0194	GDP metabolic process
D7D53_RS01030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D7D53_RS01040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7D53_RS01040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7D53_RS01045	COG0631	protein serine/threonine phosphatase activity
D7D53_RS01050	COG0515	serine threonine protein kinase
D7D53_RS01050	COG2815	serine threonine protein kinase
D7D53_RS01065	COG3425	synthase
D7D53_RS01075	COG1609	Transcriptional regulator
D7D53_RS01080	COG1621	beta-fructofuranosidase activity
D7D53_RS01095	COG2190	(PTS) system
D7D53_RS01095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7D53_RS01095	COG1263	PTS System
D7D53_RS01100	COG1940	carbohydrate kinase activity
D7D53_RS01155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D7D53_RS01175	COG1045	serine acetyltransferase
D7D53_RS01190	COG0215	cysteine-tRNA ligase activity
D7D53_RS01195	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D7D53_RS01205	COG3842	ATPase activity
D7D53_RS01240	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D7D53_RS01265	COG3590	peptidase
D7D53_RS01300	COG0745	RESPONSE REGULATOR receiver
D7D53_RS01305	COG5002	protein histidine kinase activity
D7D53_RS01310	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D7D53_RS01330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D7D53_RS01355	COG1959	2 iron, 2 sulfur cluster binding
D7D53_RS01360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7D53_RS01365	COG0765	amino acid transport
D7D53_RS01370	COG0765	amino acid transport
D7D53_RS01375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D53_RS01385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D7D53_RS01385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D7D53_RS01415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D53_RS01470	COG1573	uracil-dna glycosylase
D7D53_RS01480	COG1114	Component of the transport system for branched-chain amino acids
D7D53_RS01485	COG1363	Peptidase, m42
D7D53_RS01510	COG2226	methyltransferase
D7D53_RS01525	COG3935	DnaD domain protein
D7D53_RS01550	COG2824	Alkylphosphonate utilization operon protein PhnA
D7D53_RS01570	COG0351	phosphomethylpyrimidine kinase
D7D53_RS01575	COG4720	Psort location CytoplasmicMembrane, score
D7D53_RS01580	COG0006	proline dipeptidase activity
D7D53_RS01585	COG3442	glutamine amidotransferase
D7D53_RS01590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7D53_RS01600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7D53_RS01605	COG0513	Belongs to the DEAD box helicase family
D7D53_RS01615	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D7D53_RS01620	COG1335	isochorismatase
D7D53_RS01630	COG0577	efflux transmembrane transporter activity
D7D53_RS01635	COG1136	(ABC) transporter
D7D53_RS01640	COG0577	efflux transmembrane transporter activity
D7D53_RS01645	COG0745	RESPONSE REGULATOR receiver
D7D53_RS01650	COG5002	protein histidine kinase activity
D7D53_RS01655	COG0191	fructose-bisphosphate aldolase activity
D7D53_RS01680	COG4555	ABC transporter
D7D53_RS01695	COG1404	Belongs to the peptidase S8 family
D7D53_RS01710	COG0860	N-Acetylmuramoyl-L-alanine amidase
D7D53_RS01715	COG0583	DNA-binding transcription factor activity
D7D53_RS01735	COG1136	(ABC) transporter
D7D53_RS01750	COG2197	response regulator
D7D53_RS01760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7D53_RS01765	COG1187	pseudouridine synthase activity
D7D53_RS01770	COG1217	gtp-binding protein TYPA
D7D53_RS01790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7D53_RS01800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D7D53_RS01825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D53_RS01830	COG1126	abc transporter atp-binding protein
D7D53_RS01835	COG0765	amino acid transport
D7D53_RS01845	COG1304	FMN binding
D7D53_RS01855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D7D53_RS01860	COG0352	thiamine-phosphate diphosphorylase activity
D7D53_RS01870	COG4172	Belongs to the ABC transporter superfamily
D7D53_RS01880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D7D53_RS01895	COG0352	thiamine-phosphate diphosphorylase activity
D7D53_RS01915	COG2217	Heavy metal translocating P-type atpase
D7D53_RS01920	COG0028	Belongs to the TPP enzyme family
D7D53_RS01930	COG2723	6-phospho-beta-galactosidase activity
D7D53_RS01935	COG1482	cell wall glycoprotein biosynthetic process
D7D53_RS01940	COG0733	neurotransmitter:sodium symporter activity
D7D53_RS01945	COG0789	Transcriptional regulator
D7D53_RS01955	COG2081	HI0933 family
D7D53_RS01960	COG1307	EDD domain protein, DegV family
D7D53_RS01970	COG2131	deaminase
D7D53_RS01975	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D7D53_RS02025	COG4750	Nucleotidyl transferase
D7D53_RS02035	COG1953	Uracil, thiamine, allantoin
D7D53_RS02055	COG0617	tRNA 3'-terminal CCA addition
D7D53_RS02055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D7D53_RS02055	COG0517	IMP dehydrogenase activity
D7D53_RS02305	COG2884	Cell division ATP-binding protein ftsE
D7D53_RS02310	COG2177	Part of the ABC transporter FtsEX involved in
D7D53_RS02315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7D53_RS02315	COG2190	(PTS) system
D7D53_RS02315	COG1263	PTS System
D7D53_RS02325	COG0513	Belongs to the DEAD box helicase family
D7D53_RS02350	COG0494	nUDIX hydrolase
D7D53_RS02355	COG2378	regulation of single-species biofilm formation
D7D53_RS02365	COG0542	response to heat
D7D53_RS02370	COG4703	Protein of unknown function (DUF1797)
D7D53_RS02375	COG0765	amino acid transport
D7D53_RS02380	COG1126	abc transporter atp-binding protein
D7D53_RS02395	COG0187	DNA topoisomerase II activity
D7D53_RS02400	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D7D53_RS02405	COG0726	polysaccharide deacetylase
D7D53_RS02410	COG0656	L-ascorbic acid biosynthetic process
D7D53_RS02435	COG1053	succinate dehydrogenase
D7D53_RS02435	COG3976	FMN-binding domain protein
D7D53_RS02435	COG0431	NADPH-dependent FMN reductase
D7D53_RS02465	COG1272	protein, Hemolysin III
D7D53_RS02480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7D53_RS02485	COG1393	Belongs to the ArsC family
D7D53_RS02495	COG1126	abc transporter atp-binding protein
D7D53_RS02505	COG0492	ferredoxin-NADP+ reductase activity
D7D53_RS02525	COG0561	phosphatase activity
D7D53_RS02545	COG1349	DNA-binding transcription factor activity
D7D53_RS02550	COG1105	Belongs to the carbohydrate kinase PfkB family
D7D53_RS02555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7D53_RS02555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7D53_RS02555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7D53_RS02560	COG0697	spore germination
D7D53_RS02560	COG1674	ftsk spoiiie
D7D53_RS02570	COG1104	cysteine desulfurase activity
D7D53_RS02595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7D53_RS02605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D7D53_RS02610	COG0697	spore germination
D7D53_RS02630	COG1704	LemA family
D7D53_RS02640	COG0488	(ABC) transporter
D7D53_RS02655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D7D53_RS02670	COG0505	Belongs to the CarA family
D7D53_RS02690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D7D53_RS02695	COG0716	FMN binding
D7D53_RS02705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7D53_RS02710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7D53_RS02740	COG1078	dGTPase activity
D7D53_RS02770	COG2813	Specifically methylates the guanine in position
D7D53_RS02775	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D7D53_RS02785	COG0295	cytidine deaminase activity
D7D53_RS02790	COG1744	ABC transporter substrate-binding protein PnrA-like
D7D53_RS02795	COG3845	ABC transporter
D7D53_RS02800	COG4603	Belongs to the binding-protein-dependent transport system permease family
D7D53_RS02805	COG1079	Belongs to the binding-protein-dependent transport system permease family
D7D53_RS02815	COG0187	DNA topoisomerase II activity
D7D53_RS02860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7D53_RS02865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7D53_RS02870	COG4166	transmembrane transport
D7D53_RS02890	COG0539	negative regulation of cytoplasmic translation
D7D53_RS02895	COG1956	GAF domain-containing protein
D7D53_RS02900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7D53_RS02915	COG0719	Fe-S assembly protein
D7D53_RS02920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7D53_RS02930	COG0719	Fe-S assembly protein
D7D53_RS02935	COG0531	amino acid
D7D53_RS02940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D7D53_RS02945	COG1307	EDD domain protein, DegV family
D7D53_RS02970	COG1126	abc transporter atp-binding protein
D7D53_RS02990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D7D53_RS03005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7D53_RS03010	COG0494	nUDIX hydrolase
D7D53_RS03020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7D53_RS03030	COG2176	DNA-directed DNA polymerase activity
D7D53_RS03035	COG0584	glycerophosphoryl diester phosphodiesterase
D7D53_RS03075	COG0583	DNA-binding transcription factor activity
D7D53_RS03080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7D53_RS03085	COG0564	pseudouridine synthase activity
D7D53_RS03100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D7D53_RS03110	COG0470	DNA polymerase III
D7D53_RS03135	COG0528	UMP kinase activity
D7D53_RS03145	COG2996	Protein conserved in bacteria
D7D53_RS03155	COG1702	phosphate starvation-inducible protein PhoH
D7D53_RS03160	COG0686	Belongs to the AlaDH PNT family
D7D53_RS03170	COG1596	polysaccharide export
D7D53_RS03170	COG1555	photosystem II stabilization
D7D53_RS03175	COG0658	competence protein
D7D53_RS03175	COG2333	competence protein COMEC
D7D53_RS03200	COG0543	2 iron, 2 sulfur cluster binding
D7D53_RS03205	COG0167	dihydroorotate dehydrogenase activity
D7D53_RS03210	COG4193	domain, Protein
D7D53_RS03210	COG5263	repeat protein
D7D53_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
D7D53_RS03255	COG0745	RESPONSE REGULATOR receiver
D7D53_RS03260	COG5002	protein histidine kinase activity
D7D53_RS03290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D7D53_RS03300	COG0813	purine-nucleoside phosphorylase activity
D7D53_RS03305	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D7D53_RS03315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D7D53_RS03325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7D53_RS03330	COG0237	dephospho-CoA kinase activity
D7D53_RS03335	COG2814	Major facilitator Superfamily
D7D53_RS03340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7D53_RS03350	COG0557	exoribonuclease II activity
D7D53_RS03360	COG3615	Tellurite resistance protein tehB
D7D53_RS03360	COG0500	methyltransferase
D7D53_RS03385	COG4122	O-methyltransferase activity
D7D53_RS03400	COG1216	Glycosyl transferase, family 2
D7D53_RS03400	COG0463	Glycosyl transferase, family 2
D7D53_RS03415	COG0772	Belongs to the SEDS family
D7D53_RS03420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D7D53_RS03440	COG0358	DNA primase activity
D7D53_RS03445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7D53_RS03450	COG2151	metal-sulfur cluster biosynthetic enzyme
D7D53_RS03455	COG0438	transferase activity, transferring glycosyl groups
D7D53_RS03460	COG0438	transferase activity, transferring glycosyl groups
D7D53_RS03485	COG1438	arginine binding
D7D53_RS03490	COG2936	dipeptidyl-peptidase activity
D7D53_RS03505	COG0469	pyruvate kinase activity
D7D53_RS03510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7D53_RS03520	COG4109	DRTGG domain
D7D53_RS03525	COG0024	Methionine aminopeptidase
D7D53_RS03535	COG2822	iron ion transport
D7D53_RS03540	COG2837	iron assimilation
D7D53_RS03545	COG0672	)-iron permease
D7D53_RS03550	COG0805	protein transport
D7D53_RS03555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7D53_RS03565	COG1063	alcohol dehydrogenase
D7D53_RS03580	COG4750	Nucleotidyl transferase
D7D53_RS03585	COG0758	DNA mediated transformation
D7D53_RS03590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7D53_RS03595	COG2832	Protein of unknown function (DUF454)
D7D53_RS03600	COG3142	Participates in the control of copper homeostasis
D7D53_RS03615	COG0473	3-isopropylmalate dehydrogenase activity
D7D53_RS03640	COG1401	restriction endodeoxyribonuclease activity
D7D53_RS03665	COG1196	nuclear chromosome segregation
D7D53_RS03670	COG0196	riboflavin kinase activity
D7D53_RS03675	COG3689	TIGRFAM TIGR03943 family protein
D7D53_RS03680	COG0701	Predicted permease
D7D53_RS03695	COG2183	response to ionizing radiation
D7D53_RS03710	COG1136	(ABC) transporter
D7D53_RS03720	COG1136	(ABC) transporter
D7D53_RS03725	COG0577	efflux transmembrane transporter activity
D7D53_RS03735	COG0561	phosphatase activity
D7D53_RS03740	COG0561	phosphatase activity
D7D53_RS03745	COG0552	protein localization to endoplasmic reticulum
D7D53_RS03750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D7D53_RS03755	COG1126	abc transporter atp-binding protein
D7D53_RS03760	COG0765	amino acid transport
D7D53_RS03770	COG0556	nucleotide-excision repair
D7D53_RS03780	COG1827	regulation of RNA biosynthetic process
D7D53_RS03790	COG4684	Psort location CytoplasmicMembrane, score
D7D53_RS03795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D7D53_RS03800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D7D53_RS03820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7D53_RS03840	COG1104	cysteine desulfurase activity
D7D53_RS03845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7D53_RS03855	COG2357	RelA SpoT domain protein
D7D53_RS03865	COG0564	pseudouridine synthase activity
D7D53_RS03870	COG0280	phosphate acetyltransferase
D7D53_RS03885	COG1194	a g-specific adenine glycosylase
D7D53_RS03890	COG0745	RESPONSE REGULATOR receiver
D7D53_RS03900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D7D53_RS03910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7D53_RS03915	COG0488	(ABC) transporter
D7D53_RS03940	COG1523	belongs to the glycosyl hydrolase 13 family
D7D53_RS03945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D7D53_RS03955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D7D53_RS03965	COG0560	Phosphoserine phosphatase
D7D53_RS03985	COG4974	Belongs to the 'phage' integrase family
D7D53_RS03990	COG1396	sequence-specific DNA binding
D7D53_RS04060	COG0582	viral genome integration into host DNA
D7D53_RS04140	COG1011	Hydrolase
D7D53_RS04150	COG1051	belongs to the nudix hydrolase family
D7D53_RS04155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7D53_RS04160	COG0534	Mate efflux family protein
D7D53_RS04165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D7D53_RS04170	COG0022	dehydrogenase e1 component
D7D53_RS04175	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7D53_RS04180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7D53_RS04185	COG0095	Lipoate-protein ligase
D7D53_RS04200	COG0038	chloride channel
D7D53_RS04210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D7D53_RS04230	COG0561	phosphatase activity
D7D53_RS04235	COG1131	(ABC) transporter
D7D53_RS04245	COG2205	protein histidine kinase activity
D7D53_RS04250	COG0745	RESPONSE REGULATOR receiver
D7D53_RS04255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7D53_RS04275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D7D53_RS04280	COG1982	Orn Lys Arg decarboxylase major
D7D53_RS04290	COG0366	Alpha amylase catalytic
D7D53_RS04295	COG0135	phosphoribosylanthranilate isomerase activity
D7D53_RS04305	COG1597	lipid kinase activity
D7D53_RS04360	COG0791	NLP P60 protein
D7D53_RS04360	COG0741	lytic transglycosylase activity
D7D53_RS04485	COG1674	ftsk spoiiie
D7D53_RS04500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7D53_RS04515	COG0542	response to heat
D7D53_RS04520	COG1396	sequence-specific DNA binding
D7D53_RS04525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7D53_RS04535	COG0741	lytic transglycosylase activity
D7D53_RS04560	COG2890	protein-(glutamine-N5) methyltransferase activity
D7D53_RS04570	COG1435	thymidine kinase activity
D7D53_RS04575	COG1942	4-Oxalocrotonate Tautomerase
D7D53_RS04580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D7D53_RS04590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7D53_RS04600	COG4708	membrane
D7D53_RS04610	COG1970	mechanosensitive ion channel activity
D7D53_RS04615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D7D53_RS04620	COG2195	Cleaves the N-terminal amino acid of tripeptides
D7D53_RS04630	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7D53_RS04630	COG3443	Belongs to the bacterial solute-binding protein 9 family
D7D53_RS04645	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7D53_RS04645	COG3443	Belongs to the bacterial solute-binding protein 9 family
D7D53_RS04655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7D53_RS04660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7D53_RS04665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7D53_RS04670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7D53_RS04680	COG3684	Belongs to the aldolase LacD family
D7D53_RS04705	COG3775	system Galactitol-specific IIC component
D7D53_RS04730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D7D53_RS04735	COG0497	DNA recombination
D7D53_RS04740	COG1438	arginine binding
D7D53_RS04745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D7D53_RS04770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D7D53_RS04790	COG3764	Sortase (surface protein transpeptidase)
D7D53_RS04795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7D53_RS04810	COG0628	permease
D7D53_RS04815	COG2706	6-phosphogluconolactonase activity
D7D53_RS04825	COG0628	permease
D7D53_RS04830	COG1686	Belongs to the peptidase S11 family
D7D53_RS04835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7D53_RS04840	COG0785	Cytochrome C biogenesis protein
D7D53_RS04875	COG0356	it plays a direct role in the translocation of protons across the membrane
D7D53_RS04885	COG0826	peptidase U32
D7D53_RS04890	COG2188	Transcriptional regulator
D7D53_RS04920	COG1136	(ABC) transporter
D7D53_RS04935	COG2205	protein histidine kinase activity
D7D53_RS04940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D7D53_RS04960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7D53_RS04960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7D53_RS04965	COG0577	efflux transmembrane transporter activity
D7D53_RS04970	COG1136	(ABC) transporter
D7D53_RS04975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7D53_RS04980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7D53_RS04985	COG1268	BioY protein
D7D53_RS04990	COG4443	Transcriptional Coactivator p15 (PC4)
D7D53_RS05000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7D53_RS05000	COG1328	CTP reductase activity
D7D53_RS05055	COG1131	(ABC) transporter
D7D53_RS05070	COG0488	(ABC) transporter
D7D53_RS05080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D7D53_RS05085	COG4470	Protein conserved in bacteria
D7D53_RS05090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D7D53_RS05105	COG0167	dihydroorotate dehydrogenase activity
D7D53_RS05110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7D53_RS05140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7D53_RS05150	COG0402	S-adenosylhomocysteine deaminase activity
D7D53_RS05160	COG1132	(ABC) transporter
D7D53_RS05165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7D53_RS05165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7D53_RS05200	COG3475	LICD family
D7D53_RS05205	COG3475	LICD family
D7D53_RS05225	COG1215	transferase activity, transferring glycosyl groups
D7D53_RS05235	COG3475	LICD family
D7D53_RS05245	COG0077	Prephenate dehydratase
D7D53_RS05250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D7D53_RS05270	COG0287	Prephenate dehydrogenase
D7D53_RS05295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D7D53_RS05300	COG1368	sulfuric ester hydrolase activity
D7D53_RS05310	COG1131	(ABC) transporter
D7D53_RS05350	COG3842	ATPase activity
D7D53_RS05365	COG3527	Alpha-acetolactate decarboxylase
D7D53_RS05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7D53_RS05380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D53_RS05385	COG0704	Plays a role in the regulation of phosphate uptake
D7D53_RS05390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7D53_RS05395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7D53_RS05400	COG0581	inorganic phosphate transmembrane transporter activity
D7D53_RS05405	COG0573	inorganic phosphate transmembrane transporter activity
D7D53_RS05410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D7D53_RS05415	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D7D53_RS05415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7D53_RS05420	COG0483	inositol monophosphate 1-phosphatase activity
D7D53_RS05430	COG1393	Belongs to the ArsC family
D7D53_RS05440	COG0647	UMP catabolic process
D7D53_RS05450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7D53_RS05470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D7D53_RS05475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7D53_RS05505	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D7D53_RS05510	COG1242	4 iron, 4 sulfur cluster binding
D7D53_RS05520	COG3250	beta-galactosidase activity
D7D53_RS05525	COG0300	oxidoreductase activity
D7D53_RS05535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D7D53_RS05540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D7D53_RS05560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7D53_RS05565	COG1940	carbohydrate kinase activity
D7D53_RS05590	COG3064	Membrane
D7D53_RS05600	COG2972	Histidine kinase
D7D53_RS05605	COG4753	response regulator
D7D53_RS05605	COG2207	Transcriptional regulator
D7D53_RS05610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7D53_RS05610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7D53_RS05615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7D53_RS05620	COG0785	Cytochrome C biogenesis protein
D7D53_RS05635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D7D53_RS05655	COG1131	(ABC) transporter
D7D53_RS05670	COG1113	amino acid transport
D7D53_RS05680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7D53_RS05705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7D53_RS05710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7D53_RS05715	COG0626	cystathionine gamma-synthase activity
D7D53_RS05720	COG4166	transmembrane transport
D7D53_RS05725	COG2244	polysaccharide biosynthetic process
D7D53_RS05730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D7D53_RS05755	COG2827	Endonuclease containing a URI domain
D7D53_RS05760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D7D53_RS05765	COG1098	S1 RNA binding domain
D7D53_RS05780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7D53_RS05785	COG0629	single-stranded DNA binding
D7D53_RS05795	COG0693	protein deglycase activity
D7D53_RS05800	COG0772	Belongs to the SEDS family
D7D53_RS05805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7D53_RS05805	COG1199	ATP-dependent helicase activity
D7D53_RS05815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D7D53_RS05820	COG3250	beta-galactosidase activity
D7D53_RS05825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D7D53_RS05835	COG0017	Asparaginyl-tRNA synthetase
D7D53_RS05840	COG0436	Aminotransferase
D7D53_RS05865	COG3711	transcriptional antiterminator
D7D53_RS05880	COG0242	peptide deformylase activity
D7D53_RS05890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D7D53_RS05895	COG0488	(ABC) transporter
D7D53_RS05900	COG0617	tRNA 3'-terminal CCA addition
D7D53_RS05910	COG1307	EDD domain protein, DegV family
D7D53_RS05930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D7D53_RS05935	COG0492	ferredoxin-NADP+ reductase activity
D7D53_RS05945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D7D53_RS05955	COG0251	oxidation-reduction process
D7D53_RS05975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7D53_RS05995	COG0463	Glycosyl transferase, family 2
D7D53_RS06000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7D53_RS06005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7D53_RS06010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D7D53_RS06015	COG2384	SAM-dependent methyltransferase
D7D53_RS06020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7D53_RS06025	COG0204	Acyl-transferase
D7D53_RS06045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7D53_RS06065	COG1136	(ABC) transporter
D7D53_RS06065	COG0577	efflux transmembrane transporter activity
D7D53_RS06075	COG3583	domain protein
D7D53_RS06075	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D7D53_RS06100	COG3599	regulation of cell shape
D7D53_RS06120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D7D53_RS06140	COG1051	belongs to the nudix hydrolase family
D7D53_RS06145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7D53_RS06160	COG0768	penicillin binding
D7D53_RS06185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7D53_RS06195	COG2731	YhcH YjgK YiaL family protein
D7D53_RS06200	COG0395	ABC-type sugar transport system, permease component
D7D53_RS06205	COG1175	transmembrane transport
D7D53_RS06235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D7D53_RS06250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D7D53_RS06255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D7D53_RS06280	COG0778	Nitroreductase
D7D53_RS06285	COG1484	DNA-dependent DNA replication
D7D53_RS06300	COG1725	Transcriptional regulator
D7D53_RS06305	COG1131	(ABC) transporter
D7D53_RS06315	COG1132	(ABC) transporter
D7D53_RS06320	COG1346	cytolysis
D7D53_RS06340	COG3118	belongs to the thioredoxin family
D7D53_RS06350	COG0720	synthase
D7D53_RS06365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7D53_RS06375	COG1164	Oligoendopeptidase f
D7D53_RS06380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D7D53_RS06385	COG2264	protein methyltransferase activity
D7D53_RS06395	COG1051	belongs to the nudix hydrolase family
D7D53_RS06410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D7D53_RS06430	COG0628	permease
D7D53_RS06450	COG3711	transcriptional antiterminator
D7D53_RS06455	COG2261	transglycosylase associated protein
D7D53_RS06475	COG3237	CsbD-like
D7D53_RS06490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D7D53_RS06505	COG0135	phosphoribosylanthranilate isomerase activity
D7D53_RS06520	COG0512	Glutamine amidotransferase of anthranilate synthase
D7D53_RS06525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7D53_RS06530	COG0133	tryptophan synthase activity
D7D53_RS06535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D7D53_RS06540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D7D53_RS06550	COG1132	(ABC) transporter
D7D53_RS06555	COG1132	(ABC) transporter
D7D53_RS06560	COG2323	membrane
D7D53_RS06570	COG0708	Exodeoxyribonuclease III
D7D53_RS06585	COG2233	PERMEase
D7D53_RS06615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D7D53_RS06620	COG1609	Transcriptional regulator
D7D53_RS06625	COG1230	cation diffusion facilitator family transporter
D7D53_RS06630	COG1309	transcriptional regulator
D7D53_RS06645	COG1122	ATPase activity
D7D53_RS06655	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7D53_RS06665	COG1174	glycine betaine transport
D7D53_RS06670	COG1125	glycine betaine transport
D7D53_RS06670	COG0517	IMP dehydrogenase activity
D7D53_RS06680	COG1846	Transcriptional regulator
D7D53_RS06690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D7D53_RS06690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D7D53_RS06805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7D53_RS06840	COG4221	oxidoreductase activity
D7D53_RS06845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7D53_RS06850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7D53_RS06860	COG0504	CTP synthase activity
D7D53_RS06875	COG0525	valine-tRNA ligase activity
D7D53_RS06885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7D53_RS06955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D7D53_RS06960	COG0195	Participates in both transcription termination and antitermination
D7D53_RS06970	COG1472	Belongs to the glycosyl hydrolase 3 family
D7D53_RS06985	COG1266	CAAX protease self-immunity
D7D53_RS07065	COG2274	protein secretion by the type I secretion system
D7D53_RS07070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7D53_RS07080	COG3290	protein histidine kinase activity
D7D53_RS07105	COG1131	(ABC) transporter
D7D53_RS07110	COG0537	adenosine 5'-monophosphoramidase activity
D7D53_RS07120	COG0484	heat shock protein binding
D7D53_RS07160	COG0174	glutamine synthetase
D7D53_RS07165	COG0789	Transcriptional regulator
D7D53_RS07175	COG0126	phosphoglycerate kinase activity
D7D53_RS07195	COG1363	Peptidase, m42
D7D53_RS07200	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7D53_RS07205	COG4605	iron ion homeostasis
D7D53_RS07210	COG4604	ABC transporter, ATP-binding protein
D7D53_RS07215	COG4607	ABC-type enterochelin transport system periplasmic component
D7D53_RS07225	COG1187	pseudouridine synthase activity
D7D53_RS07280	COG0768	penicillin binding
D7D53_RS07285	COG4839	cell division protein FtsL
D7D53_RS07315	COG0386	Belongs to the glutathione peroxidase family
D7D53_RS07320	COG3583	domain protein
D7D53_RS07320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7D53_RS07320	COG3064	Membrane
D7D53_RS07335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7D53_RS07340	COG3620	sequence-specific DNA binding
D7D53_RS07345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D7D53_RS07410	COG3620	sequence-specific DNA binding
D7D53_RS07420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D7D53_RS07425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D7D53_RS07430	COG1668	transmembrane transport
D7D53_RS07435	COG4152	abc transporter atp-binding protein
D7D53_RS07440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7D53_RS07440	COG0072	phenylalanine-tRNA ligase activity
D7D53_RS07445	COG0456	acetyltransferase
D7D53_RS07455	COG1247	-acetyltransferase
D7D53_RS07465	COG0671	phosphoesterase, PA-phosphatase related
D7D53_RS07470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D7D53_RS07485	COG0569	domain protein
D7D53_RS07490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7D53_RS07495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7D53_RS07500	COG4120	Belongs to the binding-protein-dependent transport system permease family
D7D53_RS07510	COG4608	Belongs to the ABC transporter superfamily
D7D53_RS07515	COG0444	Belongs to the ABC transporter superfamily
D7D53_RS07520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7D53_RS07525	COG0601	transmembrane transport
D7D53_RS07530	COG4166	transmembrane transport
D7D53_RS07545	COG1253	flavin adenine dinucleotide binding
D7D53_RS07560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7D53_RS07575	COG3480	Lon protease (S16) C-terminal proteolytic domain
D7D53_RS07580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7D53_RS07585	COG0742	ribosomal rna small subunit methyltransferase
D7D53_RS07605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7D53_RS07610	COG1254	Belongs to the acylphosphatase family
D7D53_RS07620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D7D53_RS07630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7D53_RS07635	COG3481	metal-dependent phosphohydrolase, HD sub domain
D7D53_RS07645	COG1564	THIamine pyrophosphokinase
D7D53_RS07655	COG1162	GTPase activity
D7D53_RS07670	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D7D53_RS07675	COG0084	hydrolase, TatD family'
D7D53_RS07680	COG0582	viral genome integration into host DNA
D7D53_RS07750	COG4166	transmembrane transport
D7D53_RS07760	COG0436	Aminotransferase
D7D53_RS07770	COG0589	response to stress
D7D53_RS07775	COG0561	phosphatase activity
D7D53_RS07780	COG0252	asparaginase activity
D7D53_RS07785	COG1609	Transcriptional regulator
D7D53_RS07795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7D53_RS07795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D7D53_RS07805	COG0285	dihydrofolate synthase activity
D7D53_RS07810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7D53_RS07820	COG2252	PERMEase
D7D53_RS07825	COG0561	phosphatase activity
D7D53_RS07830	COG1064	alcohol dehydrogenase
D7D53_RS07840	COG3715	PTS system
D7D53_RS07845	COG3716	PTS system mannose fructose sorbose family IID component
D7D53_RS07850	COG3579	cysteine-type endopeptidase activity
D7D53_RS07860	COG1187	pseudouridine synthase activity
D7D53_RS07870	COG2261	transglycosylase associated protein
D7D53_RS07875	COG2309	aminopeptidase activity
D7D53_RS07885	COG2176	DNA-directed DNA polymerase activity
D7D53_RS07910	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D7D53_RS07915	COG3759	membrane
D7D53_RS07935	COG0534	Mate efflux family protein
D7D53_RS08045	COG0166	Belongs to the GPI family
D7D53_RS08055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D7D53_RS08065	COG1132	(ABC) transporter
D7D53_RS08070	COG1132	(ABC) transporter
D7D53_RS08080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7D53_RS08085	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
D7D53_RS08090	COG1518	maintenance of DNA repeat elements
D7D53_RS08095	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D7D53_RS08110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7D53_RS08125	COG0697	spore germination
D7D53_RS08220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7D53_RS08225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7D53_RS08240	COG0577	efflux transmembrane transporter activity
D7D53_RS08245	COG1136	(ABC) transporter
D7D53_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
D7D53_RS08255	COG1454	alcohol dehydrogenase
D7D53_RS08265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7D53_RS08270	COG1862	Preprotein translocase
D7D53_RS08275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D7D53_RS08285	COG1847	R3H domain protein
D7D53_RS08290	COG0706	membrane insertase activity
D7D53_RS08335	COG4537	Required for transformation and DNA binding
D7D53_RS08340	COG1459	type II secretion system
D7D53_RS08345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D7D53_RS08355	COG1063	alcohol dehydrogenase
D7D53_RS08360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7D53_RS08360	COG4499	WXG100 protein secretion system (Wss), protein YukC
D7D53_RS08370	COG2226	methyltransferase
D7D53_RS08380	COG0058	SHG alpha-glucan phosphorylase activity
D7D53_RS08385	COG1640	4-alpha-glucanotransferase
D7D53_RS08390	COG2182	Extracellular solute-binding protein
D7D53_RS08395	COG1175	transmembrane transport
D7D53_RS08400	COG3833	ABC-type maltose transport systems, permease component
D7D53_RS08405	COG5521	maltodextrose utilization protein MalA
D7D53_RS08410	COG1609	Transcriptional regulator
D7D53_RS08415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D7D53_RS08455	COG1476	TRANSCRIPTIONal
D7D53_RS08465	COG0124	histidyl-tRNA synthetase
D7D53_RS08470	COG2151	metal-sulfur cluster biosynthetic enzyme
D7D53_RS08480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D7D53_RS08485	COG3959	Transketolase, thiamine diphosphate binding domain
D7D53_RS08500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7D53_RS08520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7D53_RS08655	COG5002	protein histidine kinase activity
D7D53_RS08670	COG1215	transferase activity, transferring glycosyl groups
D7D53_RS08675	COG0569	domain protein
D7D53_RS08680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7D53_RS08690	COG0110	maltose O-acetyltransferase activity
D7D53_RS08695	COG2514	catechol 2,3-dioxygenase activity
D7D53_RS08710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7D53_RS08720	COG3583	domain protein
D7D53_RS08730	COG2222	sugar isomerase
D7D53_RS08740	COG3716	PTS system mannose fructose sorbose family IID component
D7D53_RS08745	COG3715	PTS system
D7D53_RS08750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7D53_RS08765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D7D53_RS08765	COG3064	Membrane
D7D53_RS08765	COG3583	domain protein
D7D53_RS08770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7D53_RS08775	COG2815	serine threonine protein kinase
D7D53_RS08775	COG0515	serine threonine protein kinase
D7D53_RS08795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D7D53_RS08800	COG0151	Belongs to the GarS family
D7D53_RS08805	COG0138	bifunctional purine biosynthesis protein purh
D7D53_RS08815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D7D53_RS08820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D7D53_RS08825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D7D53_RS08830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7D53_RS08845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7D53_RS08850	COG2274	protein secretion by the type I secretion system
D7D53_RS08890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7D53_RS08905	COG0436	Aminotransferase
D7D53_RS08910	COG2855	membrane
D7D53_RS08920	COG1832	CoA-binding protein
D7D53_RS08925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7D53_RS08940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D7D53_RS08950	COG0756	dUTP diphosphatase activity
D7D53_RS09020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7D53_RS09025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D7D53_RS09045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D7D53_RS09050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D7D53_RS09060	COG0012	GTP binding
D7D53_RS09070	COG0592	DNA-directed DNA polymerase activity
D7D53_RS09080	COG1475	DNA binding
D7D53_RS09085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7D53_RS09130	COG1511	domain protein
D7D53_RS09130	COG1511	domain protein
D7D53_RS09140	COG0488	(ABC) transporter
D7D53_RS09145	COG0180	Tryptophanyl-tRNA synthetase
D7D53_RS09150	COG0516	GMP reductase activity
D7D53_RS09150	COG0517	IMP dehydrogenase activity
D7D53_RS09160	COG2501	S4 domain
D7D53_RS09165	COG0612	Peptidase, M16
D7D53_RS09170	COG0612	Peptidase, M16
D7D53_RS09180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7D53_RS09185	COG1122	ATPase activity
D7D53_RS09190	COG1122	ATPase activity
D7D53_RS09195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7D53_RS09200	COG1792	Involved in formation and maintenance of cell shape
D7D53_RS09210	COG3942	CHAP domain
D7D53_RS09215	COG2348	transferase activity, transferring amino-acyl groups
D7D53_RS09240	COG1739	Uncharacterized protein family UPF0029
D7D53_RS09245	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D7D53_RS09250	COG1040	competence protein
D7D53_RS09270	COG0305	Participates in initiation and elongation during chromosome replication
D7D53_RS09290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7D53_RS09290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7D53_RS09300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7D53_RS09305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7D53_RS09310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D7D53_RS09315	COG4463	regulation of RNA biosynthetic process
D7D53_RS09320	COG0542	response to heat
D7D53_RS09325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7D53_RS09330	COG3201	nicotinamide mononucleotide transporter
D7D53_RS09350	COG1335	isochorismatase
D7D53_RS09355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D7D53_RS09375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D7D53_RS09380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7D53_RS09385	COG1696	Membrane protein involved in D-alanine export
D7D53_RS09405	COG1696	Membrane protein involved in D-alanine export
D7D53_RS09415	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D7D53_RS09420	COG1846	Transcriptional regulator
D7D53_RS09425	COG1121	(ABC) transporter
D7D53_RS09430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7D53_RS09435	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7D53_RS09435	COG3443	Belongs to the bacterial solute-binding protein 9 family
D7D53_RS09445	COG3537	Alpha-1,2-mannosidase
D7D53_RS09455	COG0383	alpha-mannosidase activity
D7D53_RS09470	COG4209	transmembrane transport
D7D53_RS09475	COG0395	ABC-type sugar transport system, permease component
D7D53_RS09480	COG1653	transport
D7D53_RS09520	COG1695	Transcriptional regulator
D7D53_RS09545	COG1760	l-serine dehydratase
D7D53_RS09550	COG1760	l-serine dehydratase
D7D53_RS09555	COG1705	Flagellar rod assembly protein muramidase FlgJ
D7D53_RS09555	COG1388	LysM domain
D7D53_RS09590	COG0494	nUDIX hydrolase
D7D53_RS09595	COG0445	tRNA wobble uridine modification
D7D53_RS09615	COG1214	PFAM Peptidase M22, glycoprotease
D7D53_RS09625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7D53_RS09630	COG1396	sequence-specific DNA binding
D7D53_RS09670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7D53_RS09675	COG1464	Belongs to the NlpA lipoprotein family
D7D53_RS09680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7D53_RS09685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7D53_RS09715	COG2972	Histidine kinase
D7D53_RS09720	COG4753	response regulator
D7D53_RS09720	COG2207	Transcriptional regulator
D7D53_RS09730	COG1780	Probably involved in ribonucleotide reductase function
D7D53_RS09745	COG1438	arginine binding
D7D53_RS09780	COG0519	Catalyzes the synthesis of GMP from XMP
D7D53_RS09805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7D53_RS09810	COG0006	proline dipeptidase activity
D7D53_RS09815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7D53_RS09825	COG1393	Belongs to the ArsC family
D7D53_RS09850	COG0285	dihydrofolate synthase activity
D7D53_RS09860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7D53_RS09895	COG0602	queuosine metabolic process
D7D53_RS09925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7D53_RS09950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA